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Journal articles on the topic 'Anti diabetic neuropathy'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Li, Hao, Shulin Liu, Zheng Wang, Yonglai Zhang та Kaiguo Wang. "Hydrogen sulfide attenuates diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor". Experimental Biology and Medicine 245, № 9 (2020): 823–34. http://dx.doi.org/10.1177/1535370220918193.

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Diabetic neuropathic pain is a frequent complication of diabetic neuropathy. The specific manifestations of diabetic neuropathic pain include spontaneous pain and hyperalgesia, which seriously affect the quality of life of patients. Previous publications have shown that H2S has both pro-nociceptive and anti-nociceptive effects. This present investigation aimed to examine the anti-nociceptive effect of H2S on diabetic neuropathic pain. We established a diabetic neuropathic pain animal model with high-glucose, high-fat diet, and STZ, then treated rats with different concentrations of H2S and inh

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Fukrapti, Ridwan, and Nada Naqiyya. "Rimpang Kunyit sebagai Terapi Pencegahan Neuropati Diabetika." Jurnal Penelitian Perawat Profesional 2, no. 2 (2020): 111–18. http://dx.doi.org/10.37287/jppp.v2i2.59.

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Neuropati diabetika merupakan salah satu komplikasi yang paling sering dialami oleh penderita diabetes melitus, baik tipe 1 maupun tipe 2. Diabetes melitus merupakan penyakit kronis tidak menular yang menjadi penyebab kematian nomor satu di dunia, yaitu sebanyak 63,5% kematian. Neuropati diabetika cenderung menyerang serabut saraf bagian distal sehingga sering ditemukan pada ekstremitas yang dapat menimbulkan komplikasi lebih lanjut berupa ulkus kaki, infeksi, gangguan gait, dan amputasi. Tujuan penulisan artikel ini adalah untuk mengetahui manfaat rimpang kunyit sebagai pencegahan terhadap ne

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3

Villarreal, Cristiane F., Dourivaldo S. Santos, Pedro S. S. Lauria, et al. "Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System." International Journal of Molecular Sciences 21, no. 14 (2020): 4850. http://dx.doi.org/10.3390/ijms21144850.

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Diabetic neuropathy is a frequent complication of diabetes. Symptoms include neuropathic pain and sensory alterations—no effective treatments are currently available. This work characterized the therapeutic effect of bergenin in a mouse (C57/BL6) model of streptozotocin-induced painful diabetic neuropathy. Nociceptive thresholds were assessed by the von Frey test. Cytokines, antioxidant genes, and oxidative stress markers were measured in nervous tissues by ELISA, RT-qPCR, and biochemical analyses. Single (3.125–25 mg/kg) or multiple (25 mg/kg; twice a day for 14 days) treatments with bergenin

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Sutikno, Nadya Adiwijaya, Rizaldy Taslim Pinzon, and Sugianto. "Effectiveness of additional therapy with vitamin D (5.000 IU) on reducing diabetic neuropathy pain." Romanian Journal of Neurology 22, no. 3 (2023): 203–7. http://dx.doi.org/10.37897/rjn.2023.3.12.

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Background and objectives. Diabetic neuropathy is microvascular complication of diabetes mellitus that attacks the peripheral nervous system and manifested as persistent electrocution pain. Patients with diabetic neuropathy are often found in conditions of vitamin D deficiency. Vitamin D has a neuroprotective effects that plays a role in increasing axonogenesis, preventing nerve degeneration, and is an anti-inflammatory agent that can reduce diabetic neuropathy pain. Determine the effectiveness of additional therapy with Vitamin D 5.000 IU on the reduction of diabetic neuropathy pain in patien

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Adsul, Samruddhi* Pandit Ashwini Dahale Raju. "Review On Detection of Barleria Cuspidata Leaves on The Antidiabetic Activity." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1739–46. https://doi.org/10.5281/zenodo.14249778.

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Barleria cuspidata, a plant in the Acanthaceae family, is known for its medicinal properties, including anti-diabetic and anti-asthmatic properties. Studies suggest these effects are attributed to the use of antibiotics and anti-diabetic extracts. However, there is limited research on other species. This review examines the phytochemistry and biological characteristics of Barleria, focusing on its traditional uses. betic extracts. Diabetes mellitus, a global health issue, affects 285 million people, 6.4% of the adult population, due to obesity and aging. With 50% of presumed This chapter discu

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Kajikawa, Yoko, Hiroshi Yokomi, Soshi Narasaki, et al. "Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Diabetes-Induced Neuropathic Pain." Journal of Clinical Medicine 13, no. 14 (2024): 4276. http://dx.doi.org/10.3390/jcm13144276.

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Background: Diabetic neuropathic pain is a known complication of diabetes mellitus (DM) and results from the complex interaction of various factors affecting the nervous system. Yokuansan (YKS) is a versatile traditional Japanese herbal medicine with a wide range of applications, especially in pain management and neurological manifestations. YKS has analgesic properties for nerve damage and is a potential treatment for DM-induced neuropathic pain, especially in patients with diabetic neuropathy. Thus, we examined the anti-allodynic effect of YKS on DM-induced neuropathic pain. Methods: All exp

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Habibi, Abdolhamid, Asma Taheri, and Saba Habibi. "Attenuation of Some Inflammatory Markers by Endurance Training in the Spinal Cord of Rats with Diabetic Neuropathic Pain." Contrast Media & Molecular Imaging 2022 (May 18, 2022): 1–9. http://dx.doi.org/10.1155/2022/6551358.

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Nervous inflammation is an important component of the pathogenesis of neurodegenerative diseases including chronic diabetic neuropathic pain. In order to obtain a decrease in the progression of diabetic neuronal damage, it may be necessary to examine therapeutic options that involve antioxidants and anti-inflammatory agents. The aim of this study was to investigate the attenuation of inflammatory factors with endurance training in the spinal cord of rats with neuropathic pain. Thirty-two 8-week-old male Wistar rats (with a weight range of 204 ± 11.3 g) were randomly divided into 4 groups (n =

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8

Venugopalaiah Penabaka, Kanchi Nidhish, Devalaraju Venkata Subba Saisuma Mounika, Indla Vishnu Priya, Vadde Tulasinath, and Yadala Prapurna Chandra. "A review on comparative study of effectiveness of pregabalin and carbamazepine in painful diabetic peripheral neuropathy using mc gill's pain questionnaire." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 133–37. http://dx.doi.org/10.30574/wjarr.2024.21.3.0459.

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Diabetic neuropathy is a unique degenerative disorder of the peripheral nervous system that preferentially targets sensory axons and autonomic axons. The loss of sensory function that begins distally in the lower extremities is known as Diabetic neuropathy. It is characterized by burning pain, paresthesias and numbness in stocking glove pattern that progress proximally from the feet and hands. Diabetic neuropathy is a highly prevalent condition that substantially affects patients by increasing falls causing pain and reducing quality of life. The major risk factors for diabetic neuropathy is hy

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Venugopalaiah, Penabaka, Nidhish Kanchi, Venkata Subba Saisuma Mounika Devalaraju, Vishnu Priya Indla, Tulasinath Vadde, and Prapurna Chandra Yadala. "A review on comparative study of effectiveness of pregabalin and carbamazepine in painful diabetic peripheral neuropathy using mc gill's pain questionnaire." World Journal of Advanced Research and Reviews 21, no. 3 (2024): 133–37. https://doi.org/10.5281/zenodo.14049862.

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Diabetic neuropathy is a unique degenerative disorder of the peripheral nervous system that preferentially targets sensory axons and autonomic axons. The loss of sensory function that begins distally in the lower extremities is known as Diabetic neuropathy. It is characterized by burning pain, paresthesias and numbness in stocking glove pattern that progress proximally from the feet and hands. Diabetic neuropathy is a highly prevalent condition that substantially affects patients by increasing falls causing pain and reducing quality of life. The major risk factors for diabetic neuropathy is hy

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10

Kaki, A., M. Nikbakht, A. H. Habibi, and H. F. Moghadam. "Effect of aerobic exercise on innate immune responses and inflammatory mediators in the spinal cord of diabetic rats." Comparative Exercise Physiology 16, no. 4 (2020): 293–301. http://dx.doi.org/10.3920/cep190050.

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Neuronal inflammation is one of the pathophysiological causes of diabetes neuropathic pain. The purpose of this research was to determine the effect of aerobic exercise on innate immune responses and inflammatory mediators in the spinal dorsal horn in rats with diabetic neuropathic pain. 40 eight-week-old male Wistar rats (weight range 220±10.2 g) were randomly divided into four groups of (1) sedentary diabetic neuropathy (SDN), (2) training diabetic neuropathy (TDN), (3) training control (TC), and (4) sedentary control (SC). Diabetes was induced by injection of streptozocin (50 mg/kg). Follow

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11

Sood, Ankita, Bimlesh Kumar, Sachin Kumar Singh, et al. "Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy." Current Pharmaceutical Design 26, no. 42 (2020): 5468–87. http://dx.doi.org/10.2174/1381612826666200826164322.

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Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, th

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Sirisha, Allampalli, Girwar Singh Gaur, Pravati Pal, Zachariah Bobby, Bharathi Balakumar, and Gopal Krushna Pal. "Effect of honey and insulin treatment on oxidative stress and nerve conduction in an experimental model of diabetic neuropathy Wistar rats." PLOS ONE 16, no. 1 (2021): e0245395. http://dx.doi.org/10.1371/journal.pone.0245395.

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Diabetic neuropathy is the most common complication affecting more than 50% of patients with longstanding diabetes. Till date, there are no reports to explain the scientific basis of alternative medicine as an adjunct therapy for treating diabetic neuropathy. Hence, we studied the effect of honey and insulin treatment on hyperglycemia, dyslipidemia, oxidant and anti-oxidant status and nerve conduction in experimental diabetic neuropathy Wistar rats. In this experimental study, forty healthy male Wistar albino rats of 10–12 weeks age, weighing between 150 to 200g were obtained from our institut

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Ekinci, Bilge, Bahadir Suleyman, Renad Mammadov, et al. "The effect of carvacrol upon experımentally ınduced dıabetıc neuropathy and neuropathıc paın ın rats." Acta Poloniae Pharmaceutica - Drug Research 79, no. 5 (2023): 707–15. http://dx.doi.org/10.32383/appdr/155354.

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Diabetic neuropathies are the most frequent complication of diabetes. While numerous metabolic pathways are disrupted in diabetic neuropathy, oxidative stress has been indicated as a significant reason for this condition. In this study, the effect of carvacrol, which has antioxidant effects, on experimental diabetic neuropathy and neuropathic pain was investigated. Alloxan was used to induce diabetes in the experiment. Diabetes was created by administering 120mg/kg of alloxan intraperitoneally (i.p) once a day for 3 days. Rats with a blood glucose concentration above 250mg/kg in the blood take

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14

Parfenov, Vladimir A., and Mariya V. Konyashova. "Treatment of painful diabetic neuropathy." Consilium Medicum 23, no. 11 (2021): 841–46. http://dx.doi.org/10.26442/20751753.2021.11.201230.

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Painful diabetic neuropathy is observed in almost half of patients with diabetes mellitus (DM) and is associated with a decrease in the quality of life, emotional disorders, sleep disorders. The achievement and maintenance of the normal level of glucose in the blood is the basis for the prevention and treatment of DM, but this often does not allow the patient from pain and other clinical manifestations of neuropathy. Drug diabetic neuropathy therapy methods are discussed, the results of randomized placebo controlled studies on the efficiency and side effects of various drugs are analyzed. It i

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Mohammed, Mohammed Mahmood, Rusul AbdulKareem Hadi, and Isam Noori Salman. "Potential Positive Effects using Coenzyme Q10 Supplement as Adjuvant Therapy to Gabapentin for Managing Diabetic Neuropathy." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, no. 2 (2022): 177–83. http://dx.doi.org/10.31351/vol31iss2pp177-183.

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The most prevalent chronic complication of diabetes mellitus is diabetic neuropathy. The pathogenesis of diabetic neuropathy is exacerbated by hyperglycemia-induced oxidative stress, which causes nerves to deteriorate in a programmed manner. Many clinical trials depend on supplement in an attempt to improve neuropathy symptoms such as (pain & tingling) and patient quality of life, one of them is Coenzyme Q10 which is reported to have an anti-inflammatory and antioxidant effects, and was totally nontoxic and non-reported side effects. This study aimed to evaluate using a Coenzyme Q10 supple

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Montagnoli, Tadeu Lima, Aimeé Diogenes Santos, Susumu Zapata Sudo, et al. "Perspectives on Stem Cell Therapy in Diabetic Neuropathic Pain." Neurology International 16, no. 5 (2024): 933–44. http://dx.doi.org/10.3390/neurolint16050070.

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Diabetes mellitus-related morbidity and mortality are primarily caused by long-term complications such as retinopathy, nephropathy, cardiomyopathy, and neuropathy. Diabetic neuropathy (DN) involves the progressive degeneration of axons and nerve fibers due to chronic exposure to hyperglycemia. This metabolic disturbance leads to excessive activation of the glycolytic pathway, inducing oxidative stress and mitochondrial dysfunction, ultimately resulting in nerve damage. There is no specific treatment for painful DN, and new approaches should aim not only to relieve pain but also to prevent oxid

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Baum, Petra, Klaus V. Toyka, Matthias Blüher, Joanna Kosacka, and Marcin Nowicki. "Inflammatory Mechanisms in the Pathophysiology of Diabetic Peripheral Neuropathy (DN)—New Aspects." International Journal of Molecular Sciences 22, no. 19 (2021): 10835. http://dx.doi.org/10.3390/ijms221910835.

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The pathogenesis of diabetic neuropathy is complex, and various pathogenic pathways have been proposed. A better understanding of the pathophysiology is warranted for developing novel therapeutic strategies. Here, we summarize recent evidence from experiments using animal models of type 1 and type 2 diabetes showing that low-grade intraneural inflammation is a facet of diabetic neuropathy. Our experimental data suggest that these mild inflammatory processes are a likely common terminal pathway in diabetic neuropathy associated with the degeneration of intraepidermal nerve fibers. In contrast t

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V. Shrirao, A., N. Y. Bhiwgade, D. S. Mohale, N. I. Kochar, and A. V. Chandewar. "Effects Of Acalypha Hispida: Restorative Perspectives of Stz-Induced Diabetic Peripheral Neuropathy in Sprague-Dawley Rats." Journal of Neonatal Surgery 14, no. 22S (2025): 107–17. https://doi.org/10.63682/jns.v14i22s.5455.

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Oxidative stress has a key role in the pathogenesis and progress of diabetic peripheral neuropathy (DPN), one of the most common and debilitating complications of diabetes mellitus. Acalypha hispida is a treasure of multiple pharmacological properties and presently leaves of this plant have been explored to evaluate the protective effects against Streptozotocin-induced diabetic neuropathy in rats. Male Sprague-Dawley rats were injected with Streptozotocin (STZ) (60 mg/kg i.p.) to induce diabetes. Post 21 days of STZ induction, animals were treated with ethanolic extract of Acalypha hispida (20

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Kousar, Begum* Naziya Begum Shaik Reshma Wajiha Fatima Mariyanaaz Ali and Ayesha Sultana. "PTEROCARPUS MARSUPIUM EXTRACTION AND EVALUATION FOR DIABETIC NEUROPATHY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1888–97. https://doi.org/10.5281/zenodo.826969.

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Herbal medicines are considered to offer gentle means of managing chronic diseases at a lower cost. Traditional Medicines derived from medicinal plants are used by about 60% of the world’s population. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In India it is proving to be a major health problem, especially in the urban areas. Pterocarpus marsupium. (PM) heartwood and bark have been majorly used as antidiabetic remedies in many cultures for thousands of years. The aim of this research is to address the existing evidence on antidiabe

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Ameyaw, Elvis Ofori, Ernest Obese, Du-Bois Asante, et al. "Effect of xylopic acid on alloxan-induced diabetic neuropathy in rats." International Journal of Basic & Clinical Pharmacology 10, no. 4 (2021): 333. http://dx.doi.org/10.18203/2319-2003.ijbcp20211011.

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Background: Neuropathic pain is a very disturbing condition commonly found in diabetic patients. This study investigated xylopic acid (XA), the major constituent of Xylopia aethiopica in diabetic neuropathy as well as established possible toxicity of the compound on some selected tissues.Methods: Diabetes was induced in six groups of male rats with 120 mg/kg alloxan monohydrate. Diabetes was confirmed as a blood glucose level >15 mmol/dl. Neuropathic pain was confirmed on day three post-diabetes induction and treatment with 10 mg/kg, 30 mg/kg or 100 mg/kg xylopic acid, 10 mg/kg glibenclamid

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Abo-Salem, Osama M. "Kaempferol Attenuates the Development of Diabetic Neuropathic Pain in Mice: Possible Anti-Inflammatory and Anti-Oxidant Mechanisms." Open Access Macedonian Journal of Medical Sciences 2, no. 3 (2014): 424–30. http://dx.doi.org/10.3889/oamjms.2014.073.

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BACKGROUND: Diabetic neuropathic pain (DNP) is one of the most difficult types of pain to treat. Many studies emphasized on the role of microglial cells, oxidative stress (OS) and inflammatory cytokines (IC) in the development of diabetic neuropathy (DN).AIM: Present study was designed to evaluate the effect of kaempferol in attenuation of DN in mice. METHODS: Diabetes was induced in mice by i.p. injection of a single dose of streptozotocin (STZ) (200 mg/kg). Cold allodynia, thermal hyperalgesia and chemical hyperalgesia were assessed, as well as markers of inflammation and OS.RESULTS: Diabeti

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Ray, Jasaswi, Chinmaya Keshari Sahoo, Rajashree Mohanty, Rakesh Sahoo, and Rajashree Dalai. "A Review on Diabetic Peripheral Neuropathy." Journal of Drug Delivery and Therapeutics 11, no. 2-S (2021): 121–25. http://dx.doi.org/10.22270/jddt.v11i2-s.4642.

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Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and type 2 diabetes affecting over 90% of the diabetic patients. Due to the toxic effects of hyperglycemia there is development of this complication. It is typically characterized by significant deficits in tactile sensitivity, vibration sense, lower-limb proprioception, and kinesthesia. Painful DPN has been shown to be associated with significant reductions in overall quality of life, increased levels of anxiety and depression, sleep impairment, and greater gait variability. Hence DPN is often inadequately treated, a

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M. Amin, Gulabakh, Bushra Hassan Marouf, and Hiwa Namiq. "The Effects of Resveratrol Supplementation on the Quality of Life of Diabetic Patients with Neuropathy: Small Randomized Clinical Trial." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, no. 3 (2023): 118–27. http://dx.doi.org/10.31351/vol32iss3pp118-127.

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The diabetic neuropathy complication exerts a considerable decline in the level of patient’s well-being. The main approaches to hamper the progression of diabetic complications and improve patient’s life quality are controlling the glycemic levels and amelioration of the hyperglycemia-induced neuroinflammation, oxidative stress and pain. Supplementation of appropriate anti-inflammatory and anti-oxidants such as resveratrol may therefore be effective in the management of diabetic complications. The aim of this trial was to assess resveratrol’s impact on improving life quality of patients with t

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Sharma, Sanjay, and Ravi Velamoor Rangarajan. "Role of Regenerative Therapeutics in Diabetic Peripheral Neuropathy: Current Advances and Future Prospects." European Journal of Medical and Health Sciences 6, no. 2 (2024): 1–10. http://dx.doi.org/10.24018/ejmed.2024.6.2.2030.

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Diabetes is a chronic metabolic condition that has far-reaching consequences for human health. If there is no appropriate therapeutic treatment, diabetic peripheral neuropathy might lead to foot ulceration and limb amputation. Conventional pharmacological therapy have weak anti-DPN activity. By stimulating nerve regeneration, addressing underlying causes of the disorder, and alleviating symptoms, stem cell therapy for diabetic peripheral neuropathy has the potential to alter the management of this debilitating illness. One of its most significant advantages is its ability to regenerate damaged

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Rashmin, Aklekar1* Rida Sayed2 Sadiya Sabahat2 Aamina Shaikh2 Mantasha Sayyed2 Rummanah Firdowsi2. "Exploring The Therapeutic Potential of Sea Buckthorn Enriched Polyherbal Oil Formulation for Alleviating Diabetic Neuropathy Pain." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 901–20. https://doi.org/10.5281/zenodo.15600592.

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Diabetic neuropathy is a chronic complication of diabetes that leads to nerve damage and persistent pain. Conventional pharmacological treatments provide symptomatic relief but often lead to side effects and limited long-term efficacy. This study focused on formulating and evaluating a polyherbal oil as a natural alternative for managing diabetic neuropathy pain. The formulation incorporated bioactive ingredients such as sea buckthorn oil, Ashwagandha, mahanarayan oil, curcumin, camphor, and peppermint oil, known for their antioxidant, anti Inflammatory, and neuroprotective properties. The stu

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Nwonu, Chukwunwike, and Patience Nwonu. "Molecular Insights and Pharmacotherapy of Diabetic Neuropathy." Saudi Journal of Medicine 9, no. 10 (2024): 460–79. http://dx.doi.org/10.36348/sjm.2024.v09i10.008.

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Background: Diabetes mellitus is a chronic disorder of energy metabolism caused by lack or decrease in the effectiveness of insulin, and is characterised by an abnormally elevated blood glucose concentrations and the development of macrovascular, microvascular and/or neuropathic complications. Diabetic neuropathy (DN) is one of the most debilitating outcomes of diabetes mellitus, and may cause pain, decreased mobility as well as amputation. Diabetes can damage the peripheral nervous system (PNS), through the induction of de-myelination in neurones, precipitated by chronic hyperglycaemia-induce

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Zochodne, Douglas W., and Lam T. Ho. "The Influence of Sulindac on Experimental Streptozotocin-Induced Diabetic Neuropathy." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 21, no. 3 (1994): 194–202. http://dx.doi.org/10.1017/s0317167100041160.

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Abstract:We studied the influence of sulindac, a nonsteroidal anti-inflammatory agent on experimental streptozotocin-induced diabetic neuropathy. Untreated diabetic rats were compared with nondiabetic rats, diabetic rats treated with low dose insulin and diabetic rats given sulindac (6.0 mg/kg by gavage 5 of 7 days weekly). Neuropathy was assessed by following serialin vivomotor and sensory caudal conduction, resistance to ischemic conduction failure, andin vitroconduction in sural myelinated and unmyelinated sensory fibers. The impact of low dose insulin and sulindac treatment on the microenv

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Lucarini, Pagnotta, Micheli, et al. "Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin." Molecules 24, no. 16 (2019): 3006. http://dx.doi.org/10.3390/molecules24163006.

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: The management of pain in patients affected by diabetic neuropathy still represents an unmet therapeutic need. Recent data highlighted the pain-relieving efficacy of glucosinolates deriving from Brassicaceae. The purpose of this study was to evaluate the anti-hyperalgesic efficacy of Eruca sativa defatted seed meal, along with its main glucosinolate, glucoerucin (GER), on diabetic neuropathic pain induced in mice by streptozotocin (STZ). The mechanism of action was also investigated. Hypersensitivity was assessed by paw pressure and cold plate tests after the acute administration of the comp

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Khan, Zarghuna, Syed H. Habib, Thamir Al-Khlaiwi, Najma Baseer, Mohammed M. Khalifa, and Syed S. Habib. "Comparison of inflammatory markers and nerve conduction studies in prediabetes and type two diabetes mellitus: A possible role in neuropathy." Journal of Family Medicine and Primary Care 14, no. 6 (2025): 2358–64. https://doi.org/10.4103/jfmpc.jfmpc_1739_24.

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ABSTRACT Background and Objective: Data on the role of anti- and proinflammatory markers in diabetes and prediabetes and their associations with diabetic neuropathy are limited. Therefore, the aim of this study was to determine and compare the associations of inflammatory markers and nerve function with blood glucose levels among diabetic patients and prediabetic patients. Methods: This was a cross-sectional study consisting of 80 participants (40 diabetic patients and 40 prediabetic patients). The assessment involved a detailed history and neurological examination, including neuropathy sympto

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B, Dharani, Sebastian Stephy, and A. Suba. "ALPHA-LIPOIC ACID IN TYPE 2 DIABETES MELLITUS: MECHANISMS, CLINICAL BENEFITS, AND IMPLEMENTATION IN THERAPY." Asian Journal of Pharmaceutical and Clinical Research 17, no. 12 (2024): 16–21. https://doi.org/10.22159/ajpcr.2024v17i12.51657.

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Diabetes Mellitus (DM) encompasses a range of metabolic disorders marked by persistent high blood glucose levels. Type 2 Diabetes Mellitus (T2DM), the more common form of the disease is characterized by insulin resistance and partial insulin deficiency. The primary contributors to mortality and morbidity in diabetes are its vascular complications. Alpha-Lipoic Acid (ALA) is an antioxidant derived from caprylic acid and synthesized within the mitochondria. Extensive research shows that ALA aids in preventing and treating Diabetic Neuropathy (DN), lowers the risk of diabetes in at-risk individua

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Sempere-Bigorra, Mar, Iván Julián-Rochina, and Omar Cauli. "Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review." Journal of Personalized Medicine 11, no. 3 (2021): 230. http://dx.doi.org/10.3390/jpm11030230.

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Background: Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level. Data sources: w

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Poornima, Vyas, Kumar Binawara Bijendra, and Shrama Pooja. "Effect of Gurmar (Gymnema sylvestre) on Sensory Nerve Conduction Velocity in the Upper Limbs of Patients with Type 2 Diabetes Mellitus." International Journal of Pharmaceutical and Clinical Research 16, no. 7 (2024): 729–34. https://doi.org/10.5281/zenodo.13119472.

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<strong>Introduction: </strong>Diabetic neuropathy, a common and troublesome complication of diabetes, causes significant morbidity and burdens diabetes care. Early detection and intervention can slow its progression. Nerve conduction studies are sensitive indicators of neuropathy severity, aiding in lesion localization and assessment of the pathophysiologic process, including clinically unrecognized alterations. Due to the chronic nature of diabetes and its impact on quality of life, many people are turning to complementary therapies. <em>Gymnema sylvestre</em>, a medicinal herb use

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Boudjenah, Nadia. "Diabetic Foot in Algeria Illustration IV – Clinical Case Report." Archives of Medical Case Reports and Case Study 6, no. 2 (2022): 01–18. http://dx.doi.org/10.31579/2692-9392/137.

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It seemed interesting to us to share this observation because it reflects our management of the diabetic patient with a wound and suffering from a severe disabling Neuropathy. Our clinical case today is a 55-year-old male. A patient with type 2 diabetes, on insulin therapy and oral anti-diabetics and being treated for high blood pressure. He came to our consultation on August 05, 2020, with an infection of the right foot, of which the starting point is the second and third toes. These ones being ischemic

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Kavya, Manjunath, Madakasira Guggilla Hariprasad, and Ashok Purnima. "Exploring the therapeutic potential of Adathoda vasica and Andrographis paniculata in alleviating diabetic cardiopathy and neuropathy: A study on high-fat diet and low-dose STZ-induced rat model." Research Journal of Chemistry and Environment 28, no. 6 (2024): 9–15. http://dx.doi.org/10.25303/286rjce09015.

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Diabetes mellitus is the metabolic illness, if it is left untreated it leads to secondary complications especially in patients suffering from T2DM. Herbal drugs are in medical use since ages. It is found that both Adathoda vasica and Andrographis paniculata exhibited anti-diabetic activity. Therefore, this study is aimed to explore their therapeutic effects in alleviating the secondary complications like neuropathy, cardiopathy using HFD-low dose STZ experimental model. Present study is designed to explore the therapeutic potential of an aqueous ethanolic extract of Adathoda vasica and Androgr

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Bondar', Irina Arkad'evna, and Olesya Yur'evna Shabel'nikova. "Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy." Diabetes mellitus 12, no. 4 (2009): 51–55. http://dx.doi.org/10.14341/2072-0351-5705.

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Aim. To determine the level of inflammation markers and their relation to endothelial dysfunction and insulin resistance in patents with type 2 diabetesmellitus and cardiovascular form of diabetic autonomous neuropathy. Materials and methods. A total of 87 patients aged 45-66 years were examined for blood insulin level, insulin resistance index (HOMA-IR), CRP,and anti-inflammatory cytokine (TNF-a, IL-1-beta, IL-6) levels. Endothelial dysfunction was estimated based on quantitative Willebrand factorassay. Vegetative disorders were detected from reflex cardiovascular ECG data. Results. The devel

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Alam, Manzar, Sabeeha Ali, Sarfraz Ahmed, et al. "Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases." International Journal of Molecular Sciences 22, no. 22 (2021): 12162. http://dx.doi.org/10.3390/ijms222212162.

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Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angiogenesis, and induced cell death, scavenging free radicals and triggering numerous anti- and pro-apoptotic proteins. The biochemistry of UA has been examined broadly based on the literature, with alterations frequently having been prepared on positions C-3 (hydroxyl), C12–C13 (double bonds), and C-28 (

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Nishvanth F, Manisha M, Ayas Baba G, and Priyadharshini S. "Herbal approaches to alleviating diabetic neuropathic pain: A comprehensive review." World Journal of Biology Pharmacy and Health Sciences 22, no. 2 (2025): 030–37. https://doi.org/10.30574/wjbphs.2025.22.2.0449.

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Diabetic neuropathic pain (DNP) is a common and debilitating complication of diabetes, characterized by a range of sensory disturbances and chronic pain, significantly affecting the quality of life. Traditional pharmacological treatments often come with side effects and limited efficacy, prompting the exploration of alternative therapeutic strategies. Herbal medicine, with its long history of use in managing various ailments, has garnered significant attention for its potential in alleviating DNP. This comprehensive review examines the role of various herbal remedies in the management of diabe

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Akbar, Shehla, Fazal Subhan, Aroosha Akbar, et al. "Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone." Nutrients 15, no. 11 (2023): 2552. http://dx.doi.org/10.3390/nu15112552.

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It is evident that inflammation and metabolic syndrome instigated by diabetes mellitus can precipitate diabetes-induced neuropathy (DIN) and pain. In order to find an effective therapeutic method for diabetes-related problems, a multi-target-directed ligand model was used. 6-Hydroxyflavanone (6-HF) carrying anti-inflammatory and anti-neuropathic pain potential due to its quadruplicate mechanisms, targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors was investigated. The anti-inflammatory potential of the test drug was confirmed utilizing in silico, in vit

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van der Sloot, Paul, Andrew Mizisin, and Douglas Zochodne. "Sulindac in Established Experimental Diabetes: a Follow-up Study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 22, no. 3 (1995): 198–201. http://dx.doi.org/10.1017/s0317167100039846.

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AbstractBackgroundIn two previous studies we have demonstrated prevention of electrophysiological abnormalities of nerve in experimental STZ (streptozotocin)-induced diabetes (ED) of rats using nonsteroidal anti-inflammatory agents: indomethacin and sulindac. Sulindac might benefit ED because it inhibits both cyclo-oxygenase and aldose reductase.MethodsIn this work, we examined whether 1 month of sulindac treatment reversed or improved established biochemical and electrophysiological abnormalities in experimental diabetes of 3 months duration. Sulindac-treated diabetic rats (6.0 mg/kg 5/7 days

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Lee, Sing-Ong, Yaswanth Kuthati, Wei-Hsiu Huang, and Chih-Shung Wong. "Semaglutide Ameliorates Diabetic Neuropathic Pain by Inhibiting Neuroinflammation in the Spinal Cord." Cells 13, no. 22 (2024): 1857. http://dx.doi.org/10.3390/cells13221857.

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Glucagon-like peptide 1 (GLP-1) receptor agonists are frequently used to treat type 2 diabetes and obesity. Despite the development of several drugs for neuropathic pain management, their poor efficacy, tolerance, addiction potential, and side effects limit their usage. Teneligliptin, a DPP-4 inhibitor, has been shown to reduce spinal astrocyte activation and neuropathic pain caused by partial sciatic nerve transection. Additionally, we showed its capacity to improve the analgesic effects of morphine and reduce analgesic tolerance. Recent studies indicate that GLP-1 synthesized in the brain ac

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Won, Jong Chul. "The Anti-Diabetic Drug Metformin from the Neuropathy Perspective." Diabetes & Metabolism Journal 44, no. 6 (2020): 840–41. http://dx.doi.org/10.4093/dmj.2020.0252.

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Raghavendra H G, Ravipraksh P, and Devanna N. "Effect of Cyperus squarrosus plant extracts on diabetic neuropathy in Streptozotocin (STZ)–induced diabetic rats." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1915–21. http://dx.doi.org/10.26452/ijrps.v12i3.4793.

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The present study was designed to evaluate the effects of Cyperus squarrosus plant extracts in streptozotocin-induced diabetic neuropathy. Diabetes was induced by a single administration of streptozotocin (65 mg/kg/intraperitoneally). After 72 hours to measure the fasting blood glucose levels, blood glucose levels more than 220 mg/dl, consider diabetic rats. Animals were divided into six groups, animals untreated with STZ were kept in a normal control group. STZ-induced diabetic rats orally administered with ethanolic and aqueous plant extracts (EECS & AECS) dose 200 & 400 mg/kg, p.o.

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Chachra, Alisha, and Sukanya Mitra. "Management of Atypical Peripheral Neuropathy." Journal of Indian College of Anaesthesiologists 4, no. 1 (2025): 14–17. https://doi.org/10.4103/jica.jica_1_25.

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Abstract Peripheral neuropathies are very common and occur due to multiple causes including diabetes, tuberculosis, vasculitis, thyroid disorders, immune-mediated diseases, Vitamin B12 deficiency, and drugs. Drug-induced peripheral neuropathy (DIPN) is potentially irreversible, resulting in sensory deficits and paresthesia. DIPN due to antitubercular drugs is common and can be implicated to linezolid, cycloserine, and isoniazid. A 40-year-old female, diabetic with multidrug-resistant tuberculosis presented with severe, sharp, burning pain in her lower limbs and was on long-acting anti-tubercul

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Alharthy, Khalid M., Mohamed F. Balaha, Sushma Devi, et al. "Ameliorative Effects of Isoeugenol and Eugenol against Impaired Nerve Function and Inflammatory and Oxidative Mediators in Diabetic Neuropathic Rats." Biomedicines 11, no. 4 (2023): 1203. http://dx.doi.org/10.3390/biomedicines11041203.

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Diabetic polyneuropathy is characterized by structural abnormalities, oxidative stress, and neuroinflammation. The current study aimed to determine the antinociceptive effects of isoeugenol and eugenol and their combinations in neuropathic pain resulting from streptozotocin (STZ)-induced diabetes and neuroinflammation. Female SD rats were categorized into normal control, diabetic control, and treatment groups. On the 28th day and 45th day, behavioral studies (allodynia and hyperalgesia) were performed to analyze the development and protection of diabetic polyneuropathy. The levels of inflammat

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Parvin Banu, Subir Mondal, Arunava Biswas, Syed Mohammed Naser, and Mausumi Niyogi. "Prescribing Trends in Diabetic Neuropathy at a Tertiary Care Hospital." Asian Journal of Medical Sciences 9, no. 5 (2018): 8–11. https://doi.org/10.71152/ajms.v9i5.3568.

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Background: Neuropathy, being a common complication of diabetes mellitus is frequently encountered in patients related to duration and severity of hyperglycaemia and had a multi-modality treatment approach by the treating physicians. Aims and Objective: To understand and analyze the current drug prescribing trends in the management of diabetic neuropathy in hospitalized and OPD patients in a tertiary care hospital. Materials and Methods: A cross sectional, observational study on (n=100) patients of either sex aged between 18 to 70 years admitted in the Department of Neuromedicine as well as vi

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Banu, Parvin, Subir Mondal, Arunava Biswas, Syed Mohammed Naser, and Mausumi Niyogi. "Prescribing Trends in Diabetic Neuropathy at a Tertiary Care Hospital." Asian Journal of Medical Sciences 9, no. 5 (2018): 8–11. http://dx.doi.org/10.3126/ajms.v9i5.20056.

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Background: Neuropathy, being a common complication of diabetes mellitus is frequently encountered in patients related to duration and severity of hyperglycaemia and had a multi-modality treatment approach by the treating physicians.Aims and Objective: To understand and analyze the current drug prescribing trends in the management of diabetic neuropathy in hospitalized and OPD patients in a tertiary care hospital.Materials and Methods: A cross sectional, observational study on (n=100) patients of either sex aged between 18 to 70 years admitted in the Department of Neuromedicine as well as visi

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Mohammad, Haider R., Mohammed M. Mohammed, and Ahmed A. Hlail. "Effect of Adding Taurine to Gabapentin on Toronto Clinical Neuropathy Score in Patient with Diabetic Neuropathy." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 1117–24. http://dx.doi.org/10.25258/ijddt.13.3.54.

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Diabetic neuropathy is a type of nerve damage that can occur in patients with diabetes mellitus. High blood glucose can injure nerves throughout the body. Diabetic neuropathy most often damages nerves in the legs and feet causing symptoms like pain and numbness. Taurine has been widely investigated regarding to its properties as a neuroprotective agent, antioxidant, anti-inflammatory in several neurodegenerative diseases. A sample consist of 40 participants enrolled randomly into two groups; group A, 20 patients treated with gabapentin capsules 300 mg once daily at night for 3 consecutive mont

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Boda, Rambabu. "Extraction and evaluation for anti-diabetic effects of some Indian plant extracts." Journal of Medical Pharmaceutical and Allied Sciences 13, no. 5 (2024): 6755–62. http://dx.doi.org/10.55522/jmpas.v13i5.6541.

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Diabetes is a metabolic disease associated with changes in the structure and function of several biological systems. The main cause of tissue injury is persistent hyperglycaemia. The past 20 years have seen increased expansion of the harmful effects of persistent hyperglycaemia, even if peripheral neuropathy and small and large vascular disease can also be used to explain diabetes-related organ failure. Liophyllum decastes, Butea monosperma, and Opuntia dillenil fruit extracts were shown to pass phytochemical testing. The study findings of Butea Monosperma, Opuntia dillenil, and Liophyllum dec

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Moradi, Mojtaba, Jalal Hassanshahi, Mohammad Reza Rahmani, Ali Shamsizadeh, and Ayat Kaeidi. "Antiapoptotic and antinociceptive effects of Achillea millefolium L. aqueous extract in rats with experimental painful diabetic neuropathy." Research in Pharmaceutical Sciences 19, no. 5 (2024): 561–72. http://dx.doi.org/10.4103/rps.rps_140_23.

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Background and purpose: Neuropathy is one of the common complications of diabetes mellitus. This study aimed to determine the analgesic and antiapoptotic effects of the aqueous extract of Achillea millefolium L. (Ach) in rats with experimental painful diabetic neuropathy by behavioral and molecular procedures. Experimental approach: Thirty male Wistar rats were divided into 5 groups including control, diabetes + saline, and diabetes + Ach extract (doses of 150, 300, and 600 mg/kg/day for 3 weeks, orally). A tail-flick test was performed to assess the pain threshold in different groups. Western

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Khan, Saif, Saheem Ahmad, Mahvish Khan, Mohtashim Lohani, Mohammad Sajid Khan, and Mohd Haneef. "Diabetic Peripheral Neuropathy: Navigating Controversies and Pioneering Advances." Advancements in Life Sciences 12, no. 1 (2025): 01. https://doi.org/10.62940/als.v12i1.3627.

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This review examines Diabetic Peripheral Neuropathy (DPN), a significant complication of diabetes affecting nearly half of diabetic patients. DPN is crucial to understand due to its high prevalence and profound impact on patients’ quality of life, causing pain, sensory loss, motor dysfunction, and heightened risks of foot ulcers and amputations. As a leading cause of disability, grasping DPN’s pathophysiology, early diagnosis, and treatment options are essential for alleviating its burden. Key facets of DPN include its complex pathophysiology stemming from chronic hyperglycemia, oxidative stre

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