To see the other types of publications on this topic, follow the link: Anti-Epilepsy Drugs.
Journal articles on the topic 'Anti-Epilepsy Drugs'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Anti-Epilepsy Drugs.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Mehr Musani, Muhammad Wasim, Hassan Salman Siddiqi, Saara Muddasir, and Fazal Manzoor Arain. "Herbal extracts: the future treatment option for drug-resistant epilepsy." Journal of the Pakistan Medical Association 73, no. 6 (2023): 1266–71. http://dx.doi.org/10.47391/jpma.7081.
Full textAbstract:
Epilepsy is a neurological disorder characterised by two or more unprovoked seizures. The high prevalence and incidence of epilepsy globally, especially in Asia, has remained a big concern over the course of centuries. Patients are usually prescribed the already known anti-epileptic drugs, but even after going through three different generations of anti-epileptic drugs, some people still suffer from drug-resistant form of epilepsy. These patients are usually prescribed a higher dose of anti-epileptic drugs, which results in more adverse effects. That is why new treatment options, like herbal extracts, should be explored for patients who do not respond to the classic anti-epileptic drugs. The current narrative review was planned to explore if herbal extracts can be the future for the treatment of drug-resistant epilepsy. Key Words: Epilepsy, Herbal extracts, Drug-resistant epilepsy, Anti-epileptic drugs.
2
Gayatri, NA, and JH Livingston. "Aggravation of epilepsy by anti-epileptic drugs." Developmental Medicine & Child Neurology 48, no. 5 (2006): 394–98. http://dx.doi.org/10.1017/s0012162206000843.
Full text
3
Rangarajan, Punitha, Kulandaiammal Moorthy, and Arunan Subbiah. "Observational study on the utilization pattern of adjuvant anti-epileptics and their adverse effects." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 170. http://dx.doi.org/10.18203/2319-2003.ijbcp20195781.
Full textAbstract:
Background: Epilepsy is a disease characterized by an enduring predisposition to generate epileptic seizures. Pharmacological therapy is the cornerstone of treatment of epilepsy. In more than 50% patients seizure not controlled with first-line anti-epileptic drugs so added with adjuvant drugs. Therefore adjuvant anti-epileptic drugs play an important role in preventing seizure remission in known epilepsy patients. Observational study was to evaluate the utilisation pattern of adjuvant anti-epileptic drugs and to assess their clinical correlation and observe the adverse effects of the adjuvant anti-epileptics.Methods: Eligible 100 patients who attended the neurology outpatient department where enrolled in the study. Demographic data, type of epilepsy, presence or absence of seizure episode (4 months), adjuvant anti-epileptic prescribed along with the first-line drugs and adverse effects were noted. Clinical correlation and rationale for the usage of adjuvant anti-epileptics were assessed. Descriptive statistics used for statistical analysis.Results: The most common types of seizures were generalised tonic clonic seizures (41%) and complex partial seizures (37%). Most commonly used 1st line drug was phenytoin tablet. Most common adjuvant anti-epileptics used were clonazepam (30), clobazam (24) tablets. Most common adverse effect noted was dizziness (31%).Conclusions: Tablet clonazepam is effective adjunct for tonic clonic seizures. Clobazam table is recommended as add-on drug for focal and generalised seizures. Adjuvant anti-epileptic drugs decrease seizure remission with fewer tolerable adverse effects.
4
Maden, Buse Nur, and Saliha Ece Acuner. "Investigation of anti-inflammatory drug usage in the treatment of epilepsy through analyzing the epilepsy-inflammation relation at the molecular level." Biotech Studies 34, SI (2025): 9–24. https://doi.org/10.38042/biotechstudies.1662530.
Full textAbstract:
Epilepsy is a neurological brain disorder that affects social life by causing seizures, loss of consciousness, and muscle contractions. The causes of epilepsy include tumors, genetic diseases, brain injuries during childbirth, and infections affecting the body. Antiepileptic drugs are commonly used for treatment, but about one-third of individuals continue to experience seizures despite medication. These drugs effectively prevent seizures but do not address the underlying mechanisms of the disease. Inflammation, i.e. biological response of the body's immune system to harmful stimuli, can be the result or cause of various diseases and is recognized as one of the contributing factors to epilepsy. This study investigates the molecular-level connection between inflammation and epilepsy through mapping transcriptomic data to reconstructed protein-protein interaction (PPI) network, reveal important subnetworks and detect potential common drug targets for inflammation and epilepsy. The most connected hub proteins of the subnetwork related to inflammation, derived from the expression data mapping are AKT1, IL6, and TLR4. After conducting molecular docking studies of anti-inflammatory drugs with these targets, Resveratrol and Fentanyl were identified as potential drugs with anti-inflammatory effects and suitable for epilepsy. Thus, we suggest further experimental studies for validation of using anti-inflammatory drugs Resveratrol and Fentanyl against epilepsy.
5
Zaib-un-nissa*, Muhammad Iqbal Suhail Ahmed Almani Aatir H. Rajput Muhammad Muneeb Hamid Memon Syed Jehangir and Shahrukh Shaikh. "CASUAL COMPARATIVE ANALYSIS OF GINGIVAL INDEX SCORE AMONG EPILEPTIC PATIENTS USING CARBAMAZEPINE, SODIUM VALPROATE AND PHENYTOIN." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1565–69. https://doi.org/10.5281/zenodo.817621.
Full textAbstract:
Abstract: Objective: This research hoped to compare the periodontal health of epileptic patients using three different anti-epilepsy drugs, namely, carbamazepine, phenytoin and sodium valproateusing the gingival index score. Methodology: This casual comparative analysis of periodontal health was conducted at Liaquat University Hospital from January to March (2017) upon 3 groups of patients, each using a different anti-epileptic drug. The groups comprised of 15 patients each and the groups were matched for age, sex and duration of drug therapy. All recordings made on the gingival index score on each patien t were carried out by two independent observers and neither of the observers knew what anti-epilepsy therapy the patients were taking. The observers had tools (other than the gingival index score and visual comparison chart) such as mouth mirror and periodontal pr obe at their disposal. Informed (written) consent was taken from the subjects and the data collected was analyzed using SPSS v. 21.0 and MS. Excel 2016. It was ensured through rigorous questioning that the patients had each been using anti-epilepsy drug monotherapy i.e. the patients had been using only one of the aforementioned drugs. This ensured the validity and reliability of the results. Result: Differences were observed in periodontal health of patients using the different anti-epilepsy drugs. Patients using sodium valproate monotherapy had the highest gingival index scores that correspond to poorer periodontal health and gingival condition. The duration of therapy was directly proportional to the higher gingival index score. Conclusion: Anti-Epilepsy drugs namely, carbamazepine, sodium valproate and phenytoin have marked ill-effects on periodontal health, as is revealed by the gingival index score. The magnitude damage that each drug causes differs and is higher than the reported literature norms of healthy individuals. Patients on sodium valproate monotherapy had the highest gingival index score followed closely by patients using phenytoin monotherpay. Carbamazepine was by far the safest of the three, with lowest gingival index score. Key Words: Epilepsy, Carbamazepine, Phenytoin, Sodium Valproate, Anti-Epilepsy Drugs, Anti-Convulsion Drugs, Periodontal Health and Gingival Index.
6
Tri Utami, Melinda, Refani Adisti Rahmadini, Adelia Putri, et al. "REVIEW ARTIKEL : PENGGUNAAN OBAT ANTI EPILEPSI DI RUMAH SAKIT." Medimuh : Jurnal Kesehatan Muhammadiyah 4, no. 2 (2023): 113–18. http://dx.doi.org/10.37874/mh.v4i2.632.
Full textAbstract:
ABSTRAK 
 Epilepsi adalah gangguan pada sistem saraf pusat akibat pola aktivitas listrik yang berlebihan di otak (Rahmat, 2021). Epilepsi memerlukan pengobatan yang lama (Dewi, 2020). Kepatuhan minum obat akan mempengaruhi hasil pengobatan. Hal ini menyebabkan penderitanya mengalami kejang secara berulang pada sebagian atau seluruh tubuh. Tujuan penelitian ini untuk mengetahui penggunaan obat antiepilepsi di Rumah Sakit dan untuk mengetahui beberapaorang yang menderita epilepsi di berbagai kota di Indonesia. Metode penelitian yang digunakan dalam artikel ini dengan mengumpulan jumlah penelitian sebanyak 11 jurnal dari situs “Google Scholar” dengan kata kunci anti epilepsi, epilepsi, pengobatan anti epilepsi, penggunaan obat anti epilepsi.
 Kata kunci : anti epilepsi, pengobatan antiepilepsi, epilepsi, penggunaan obat anti epilepsi.
 
 ABSTRACT 
 Epilepsy is the use of disordes of the central nervous system due to excessive electrical activity patterns in the brain. Epilepsy requires prolonged treatment. Medication adherence will affect the outcome of treatment. This causes the sufferer to experience repeated seizures in parts or the whole body. The purpose of this study was to dertemine the use of anti-epileptic drugs in hospitals and to find out how many people suffer from epilepsy in various cities in Indonesia. The research method used in this article by collecting 11 research journals from the “Google Scholar” site with the keywords antidpilepticm,epilepsy, anti-epileptic medication, use of antiepileptic drugs.
 
 Keywords: anti epilepsy, anti epileptic medication, epilepsy, use of anti-epileptic drugs
7
Lv, Yu-Qin, Xing Wang, Yu-Zhuang Jiao, et al. "Interactome overlap between risk genes of epilepsy and targets of anti-epileptic drugs." PLOS ONE 17, no. 8 (2022): e0272428. http://dx.doi.org/10.1371/journal.pone.0272428.
Full textAbstract:
Aanti-epileptic drugs have been used for treating epilepsy for decades, meanwhile, more than one hundred genes have been identified to be associated with risk of epilepsy; however, the interaction mechanism between anti-epileptic drugs and risk genes of epilepsy was still not clearly understood. In this study, we systematically explored the interaction of epilepsy risk genes and anti-epileptic drug targets through a network-based approach. Our results revealed that anti-epileptic drug targets were significantly over-represented in risk genes of epilepsy with 17 overlapping genes and P-value = 2.2 ×10 −16. We identified a significantly localized PPI network with 55 epileptic risk genes and 94 anti-epileptic drug target genes, and network overlap analysis showed significant interactome overlap between risk genes and drug targets with P-value = 0.04. Besides, genes from PPI network were significantly enriched in the co-expression network of epilepsy with 22 enriched genes and P-value = 1.3 ×10 −15; meanwhile, cell type enrichment analysis indicated genes in this network were significantly enriched in 4 brain cell types (Interneuron, Medium Spiny Neuron, CA1 pyramidal Neuron, and Somatosensory pyramidal Neuron). These results provide evidence for significant interactions between epilepsy risk genes and anti-epileptic drug targets from the perspective of network biology.
8
Bharat, Sharma, and Sakshi Parul. "Interactions Between Anti-Epileptic Drugs and Contraceptives: A Review." International Healthcare Research Journal 5, no. 1 (2021): RV14—RV18. https://doi.org/10.26440/IHRJ/0501.04409.
Full textAbstract:
Around half of the pregnancies in women with epilepsy are unplanned and the choice of contraceptive method in epileptic women is important, since it requires considering their possible pharmacological interactions with certain types of anti-epileptic drugs. Drugs from this class which induce hepatic enzyme activity may alter the metabolism of most hormonal methods of contraception, and this may affect their contraceptive efficacy. Hormonal contraception is regarded as highly effective, but its interaction with anti-epileptics may accelerate the metabolism of the latter with the consequent risk of failure, reduction of plasma concentration predisposing to seizures, risk of unwanted pregnancies, abortions, teratogenicity, maternal or fetal complications and difficulty in the management of epilepsy during pregnancy. In case of prescribing both medications, the combined use with a barrier method should be considered. Family planning counseling at the first visit has been shown to influence the choice of the contraceptive method. In conclusion, the different therapeutic options should be analyzed together with the epileptic patients in order to achieve and optimize the best goal for each one This article reviews these issues and offers practical recommendations for the management of contraception in epileptic patients.
9
Kulshreshtha, Dinkar, Pradeep Maurya, Ajai Singh, and Anup Thacker. "Withdrawal of anti-epileptic drugs: A review." International Journal of Epilepsy 02, no. 01 (2015): 038–43. http://dx.doi.org/10.1016/j.ijep.2015.03.002.
Full textAbstract:
AbstractAnti-epileptic drugs are the mainstay in treatment of epilepsy. It requires a strong clinical decision in patients who are well controlled on medications to withdraw anti-epileptic drugs. This decision has to be based on the clinical profile, epilepsy type, neuroimaging and electroencephalography (EEG) findings and has to be more individualized as per the patient needs. In the context of drug withdrawal, it is necessary to look into the details of why, how and when to withdraw anti-epileptics. In this article, we critically try to answer such queries and look into the established guidelines with respect to drug withdrawal. We shall look into the chances of recurrence on stopping these drugs. Also, in the end we shall discuss briefly some special clinical scenarios where decision to stop anti-epileptic drugs is a challenging task.
10
Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "The Complex Relationship between Drugs and Epileptic Patients: A Comprehensive Exploration." Journal of Trauma, Orthopaedic and Urological Nursing 2, no. 1 (2023): 7–10. https://doi.org/10.5281/zenodo.10416835.
Full textAbstract:
<em>Epilepsy is a neurological disorder manifested by recurrent seizures, influencing millions of people worldwide. Anti-epileptic drugs (AEDs) are treated as primary treatment for epilepsy. Anti-epileptic drugs show their action on various targets particularly within the brain, namely ion channels, neurological transmitter system. Types of Anti-epileptic drugs include calcium channel blockers, GABA enhancers, glutamate receptor antagonist and sodium channel blockers. Side effects of AEDs are dizziness or drowsiness, life style factors namely sleep, stress management. Some studies indicate that cannabidol (CBD) may decrease seizure frequency particularly in certain types of epilepsy. Finally it us concluded that health care professionals play a major role in monitoring and managing drug interactions, educating patients regarding potential risks and. Providing holistic care to address both seizure control and overall health.</em>
11
Mutanana, Ngonidzashe. "Challenges Associated with Anti-epilepsy Medication and Use of Complementary or Alternative Medicines among People with Epilepsy in Rural Communities of Zimbabwe." Malaysian Journal of Medical and Biological Research 6, no. 2 (2019): 77–84. http://dx.doi.org/10.18034/mjmbr.v6i2.475.
Full textAbstract:
The main objective of this study was to analyze challenges associated with anti-epilepsy medication and use of complementary or alternative medicines among people with epilepsy in rural communities of Zimbabwe. The study opted for qualitative research because it is culturally specific and data collected is contextually rich. The target population was people with epilepsy and caregivers of children with epilepsy and using a snowball sampling technique, a sample of 15 people with epilepsy and 5 caregivers of children with epilepsy was selected. The study purposively selected 2 traditional healers, 2 faith healers and 2 psychiatric nurses to have their insight on complementary and alternative medicines in the community and data was collected using face-to-face in-depth interviews. Findings revealed that anti-epilepsy medication is associated with a number of challenges in rural communities, chief among them that people with epilepsy are not informed about the side-effects of anti-epilepsy medication such as stomach upset, dizziness, blurred vision and sexual dysfunction. As a plateau to these anti-epilepsy medication side-effects, they make use of traditional and spiritual medicines either as complementary or alternative to anti-epilepsy medication. They are also facing challenges of Anti-Epilepsy Drugs shortages and long distances to health facilities and consequently, they opt for complementary or alternative medicines to sustain their livelihoods. The study recommends modern healthcare providers to supply people with epilepsy with adequate information on the side-effects of drugs. Healthcare providers must have enough information on complementary and alternative medicines. Traditional and faith healers must be accommodated in epilepsy treatment because of sociocultural aspects, and they too must be educated on the relevance of the modern healthcare system in epilepsy treatment. The study finally recommends a study on the multi-cultural approach of epilepsy management in Zimbabwe.
12
Miziak, Barbara, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, and Stanisław J. Czuczwar. "Anti-Epileptogenic Effects of Antiepileptic Drugs." International Journal of Molecular Sciences 21, no. 7 (2020): 2340. http://dx.doi.org/10.3390/ijms21072340.
Full textAbstract:
Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute brain insults leading to acquired epilepsy via the process of epileptogenesis. Two questions thus arise: (1) Are AEDs able to inhibit SE-induced neurodegeneration? and (2) if so, can a probable neuroprotective potential of particular AEDs stop epileptogenesis? An affirmative answer to the second question would practically point to the preventive potential of a given neuroprotective AED following acute brain insults. The available experimental data indicate that diazepam (at low and high doses), gabapentin, pregabalin, topiramate and valproate exhibited potent or moderate neuroprotective effects in diverse models of SE in rats. However, only diazepam (at high doses), gabapentin and pregabalin exerted some protective activity against acquired epilepsy (spontaneous seizures). As regards valproate, its effects on spontaneous seizures were equivocal. With isobolography, some supra-additive combinations of AEDs have been delineated against experimental seizures. One of such combinations, levetiracetam + topiramate proved highly synergistic in two models of seizures and this particular combination significantly inhibited epileptogenesis in rats following status SE. Importantly, no neuroprotection was evident. It may be strikingly concluded that there is no correlation between neuroprotection and antiepileptogenesis. Probably, preclinically verified combinations of AEDs may be considered for an anti-epileptogenic therapy.
13
Kotov, A. S., and K. V. Firsov. "Epilepsy and Hyperthermia: a Review." Comorbidity neurology 2, no. 1 (2025): 13–19. https://doi.org/10.62505/3034-185x-2025-2-1-13-19.
Full textAbstract:
INTRODUCTION. Viral and bacterial infections accompanied by a rise in temperature (hyperthermia) are among the most common (if not the most common) diseases in the world. These conditions may pose an additional danger to patients with epilepsy, who may experience an increase in seizures during fever. The purpose of this review is to familiarize colleagues with the risk factors for seizures, as well as the nuances of using various classes of drugs in patients with "common" infections accompanied by hyperthermia and comorbid epilepsy. AIM. To identify the features of the interaction between epilepsy and diseases (viral and bacterial infections) accompanied by an increase in temperature (hyperthermia). MATERIALS AND METHODS. Materials and methods. The PubMed databases were analyzed from 1997 to 2025 using the keywords "epilepsy, fever" and the Elibrary scientific library from 2010 to 2025 using the keywords "epilepsy, hyperthermia, fever, acute respiratory viral infections". More than 1,500 articles and 100 meta-analyses were identified, data on the interaction of hyperthermia, fever, intoxication, viral and bacterial infections and epilepsy, the specifics of the use of non-steroidal anti-inflammatory drugs and antibiotics in patients with epilepsy, and the interaction of these classes of drugs with anti-seizure medications were found, summarized and presented in the article. DISCUSSION. The review presents information on risk factors for epileptic and febrile seizures in adults and children against the background of hyperthermia, the features of the combination and side effects of various classes of drugs for the treatment of infections and epilepsy, respectively. CONCLUSION. Viral and bacterial infections accompanied by hyperthermia increase the risk of seizures in children and adults with epilepsy and can also cause febrile seizures in children. The main contribution to the provocation of seizures is made by fever and intoxication, to a lesser extent - the direct effect of the infectious agent on the brain, and to an even lesser extent - the side effects of drugs for the treatment of fever and / or infection. For the treatment of epilepsy, drugs with minimal effect on liver metabolism seem to be safer, for the treatment of infection, non-steroidal anti-inflammatory drugs and / or antibiotics are prescribed according to indications, the likelihood of provoking seizures by them is usually much less than the potential benefit.
14
Mawuntu, Arthur H. P., Herlyani Khosama, Corry N. Mahama, Sekplin A. S. Sekeon, and Karema Winifred. "Anti-epileptic drugs adherence of epilepsy patients in Indonesia." International Journal Of Community Medicine And Public Health 7, no. 6 (2020): 2082. http://dx.doi.org/10.18203/2394-6040.ijcmph20202456.
Full textAbstract:
Background: Adherence to medication is an important component of successful epilepsy treatment. However, the disease’s long-term treatment makes it difficult to achieve good adherence. This study aimed to assess the adherence level of anti-epileptic drugs (AEDs) among adult epilepsy patients in Indonesia and its associated factors.Methods: We reviewed the medical records of epilepsy patients in a tertiary public hospital between September 2018 and August 2019. Subjects were patients who were electro-clinically diagnosed with any type of epilepsy, have been taken at least one AED for at least three months, have a record of Morisky medication adherence scale 8 items (MMAS-8) score, and aged 20 years old and above. The level of adherence was measured by the MMAS-8 Indonesian version.Results: We found 97 eligible subjects and the majority were males (56.7%), unemployed (69.1%), and aged ≥30 years old (55.7%). Most subjects (41.2%) showed a high adherence level. The remaining 30.9% and 27.8% had a moderate and low adherence level respectively.Conclusions: This study reveals that high AEDs adherence is associated with being male, younger than 30 years of age, received monotherapy instead of polytherapy, and no memory impairment. A further investigation related to the reason why these factors play roles in the Indonesian setting is important to design appropriate strategies to improve AEDs adherence of epilepsy patients.
15
Aref, Diyar, Amanda Armstrong, Rosul Gulam, and Sanarya Namuq. "Prescribing for established adult patients with epilepsy." Journal of Prescribing Practice 1, no. 11 (2019): 566–69. http://dx.doi.org/10.12968/jprp.2019.1.11.566.
Full textAbstract:
This article examines prescribing for patients who have epilepsy and are on anti-epilepsy medication. It highlights the need to be vigilant when prescribing for patients with epilepsy, and be aware of the risks of any medication that you are prescribing and the impact it could have on the patient's epilepsy. The articles establishes that some patients are on anti-epilepsy drugs for indications other than epilepsy and therefore it is important to take a good medical and drug history before prescribing. When prescribing repeat anti-epilepsy medication for established patients, who are already under the care of a neurologist, the importance of the use of the specific brand and that it is in line with local and national policies is essential.
16
Yadav, BK, and L. Sharma. "Initial management of epilepsy." Journal of General Practice and Emergency Medicine of Nepal 1, no. 1 (2010): 41–45. http://dx.doi.org/10.59284/jgpeman200.
Full textAbstract:
There is no sufficient evidence to prove one anti epileptic drug to be superior to another, so selection of antiepileptic drugs should be individualized according to the patient. Monotherapy should be the goal when anti epileptic drug treatment is instituted for epilepsy.
17
Mishra, Ashish, Jeetendra Kumar Gupta, Nilesh Jain, and Sunil Mistry. "Preliminary evaluation of melatonin in the kindling model of epilepsy." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 223–26. http://dx.doi.org/10.22270/jddt.v9i2-s.2496.
Full textAbstract:
During the past decades, epilepsy syndrome has been depicted across India as well as worldwide and this leads to increasing mortality and morbidity rate. Researchers are trying to investigate the responsible causes and risk factors for seizure occurrence. Epilepsy is a chronic disorder which is derived from a Latin word ‘sacire’ meaning ‘convulsive attack’ and is expressed as a paroxysmal experience appointed to atypical, unnecessary or concurrent neuronal bustle in the brain. The treatment of epilepsy involves the use of anti-epileptic drugs i.e. Sodium valproate, phenytoin, carbamazepine. Despite being treated with the available anti-convulsant drugs, this disease is still prevalent worldwide. So, as an adjuvant treatment melatonin exhibit an anti-epileptic activity in several animal models of epilepsy. However, its anti-epileptic potential has yet to be evaluated in Pentylenetetrazole (PTZ) induced model of epilepsy through kindling phenomenon. Rats were injected with a dose of (35-55 mg/kg) of pentylenetetrazole (PTZ) up to twenty days in alternate days. Observed the convulsive behavior of rats for thirty minutes immediately after PTZ injection. The entire treatment schedule includes the administration of melatonin (75 mg/kg) one hour prior to the PTZ administration. Sodium valproate was used as standard drug for this kindling model of epilepsy. Keywords: Pentylenetetrazole, Melatonin, Sodium valproate, Gamma-amino butyric acid
18
Chintalapati, Janaki, Arvind Kumar, MV Hosur, and Supriya N. Pal. "TREADS: Target Research for Anti-epileptic Drugs Using Data Science." Neurology India 72, no. 3 (2024): 620–25. http://dx.doi.org/10.4103/neuroindia.ni_261_21.
Full textAbstract:
Context: Epilepsy is a common neurological disease and is classified into different types based on features such as the kind of seizure, age of onset, part of brain effected, etc. There are nearly 30 approved anti-epileptic drugs (AEDs) for treating different epilepsies and each drug targets proteins exhibiting a specific molecular mechanism of action. There are many genes, proteins, and microRNAs known to be associated with different epileptic disorders. This rich information on epilepsy-associated data is not available at one single location and is scattered across multiple publicly available repositories. There is a need to have a single platform integrated with the data, as well as tools required for epilepsy research. Methods and Material: Text mining approaches are used to extract data from multiple biological sources. The data is curated and populated within an in-house developed epilepsy database. Machine-learning based models are built in-house to know the probability of a protein being druggable based on the significant protein features. A web interface is provided for the access of the epilepsy database as well as the ML-based tool developed in-house. Results: The epilepsy-associated data is made accessible through a web browser. For a protein of interest, the platform provides all the feature values, and the results generated using different machine learning models are displayed as visualization plots. Conclusions: To meet these objectives, we present TREADS, a platform for epilepsy research community, having both database and an ML-based tool for the study of AED targets. To access TREADS: https://treads-aer.cdacb.in
19
Absar Neyan A, Ajans Samuel J, Amirtha Varshini M K M, and Mohan Kumar M. "Factors influencing withdrawal of anti-epileptic drugs and management of recurrent seizure: A systematic review." International Journal of Science and Research Archive 13, no. 1 (2024): 419–25. http://dx.doi.org/10.30574/ijsra.2024.13.1.1658.
Full textAbstract:
Objective: This study aims to investigate the risk factors associated with seizure recurrence following the withdrawal of antiepileptic drugs (AEDs) in patients with epilepsy. Method: A systemic review of recent literature and clinical studies was conducted, focusing on variables such as patient demographics, epilepsy characteristics, treatment history, comorbid condition, adherence to treatment, withdrawal protocols and seizure outcomes were included. Results: factors like polypharmacy AED drugs, undesirable effects, cognitive impairment, cost, compliance are leads to withdrawal of antiepileptic drugs. which cause recurrence of seizure and severe risk. Only seizure free patient can slowly withdrawal the Anti-epileptic drugs. Management strategies for recurrent seizures post-withdrawal varied, including AED reinitiation, dose adjustment, adjunctive therapies, and epilepsy surgery. Conclusion: Healthcare were optimizing outcomes for epilepsy patients by using gradual tapering strategies, adjunctive therapies, patient education, and diligent follow-up to minimize seizure recurrence and ensure AED withdrawal efficacy.
20
Boshuisen, K., O. Braams, A. Jennekens-Schinkel, P. van Rijen, and O. van Nieuwenhuizen. "ETO04 Anti-epileptic drugs after epilepsy surgery in children." European Journal of Paediatric Neurology 11 (September 2007): 40–41. http://dx.doi.org/10.1016/s1090-3798(08)70395-7.
Full text
21
Vezzani, Annamaria. "Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?" Expert Opinion on Drug Safety 14, no. 4 (2015): 583–92. http://dx.doi.org/10.1517/14740338.2015.1010508.
Full text
22
Radu, Beatrice Mihaela, Florin Bogdan Epureanu, Mihai Radu, Paolo Francesco Fabene, and Giuseppe Bertini. "Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy." Epilepsy Research 131 (March 2017): 15–27. http://dx.doi.org/10.1016/j.eplepsyres.2017.02.003.
Full text
23
Gude, Dilip. "Epilepsy, anti-epileptic drugs and bone health in children." Journal of Pediatric Neurosciences 6, no. 1 (2011): 93. http://dx.doi.org/10.4103/1817-1745.84425.
Full text
24
Skovola, Eleftheria, Giunio Bruto Cherubini, and Sara Ferrini. "Alternative drugs to phenobarbital in canine epileptic patients." Companion Animal 26, no. 5 (2021): 1–11. http://dx.doi.org/10.12968/coan.2020.0076.
Full textAbstract:
Epilepsy is one of the most common chronic neurological diseases in companion animals. The first choice for anti-epileptic drugs has consistently been phenobarbital. However, the presence of side effects or contraindications for its use, or poor control of seizures in some canine patients, may require the replacement of phenobarbital, or the addition of more anti-epileptic drugs to the treatment protocol. This article describes the indications, mechanism of action, pharmacokinetics, recommended doses and adverse effects of anti-epileptic drugs whic can be used in place of phenobarbital. A review of the current literature and the administration of each anti-epileptic drug in veterinary practice is also presented. Bromide and imepitoin are overall good options for adjunctive or alternative anti-epileptic medications. However, the pros and cons of each drug need to be considered, in order to choose the most suitable therapeutic protocol for each case. Pharmaco-resistant epilepsy occurs when seizure activity fails to be controlled with two or more anti-epileptic drugs. In the latter situation, some more recently studied alternative anti-epileptic drugs can be considered, such as levetiracetam, gabapentin, pregabalin, zonisamide, felbamate and topiramate. Non-medical options include a medium chain triglyceride oil enriched diet, and cannabidiol.
25
Anwar, T. T. Muhammed, P. P. Muhamed Faris, and ,. Thansiha. "A Systematic Review on Lamotrigine Induced Skin Rashes." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 146–51. http://dx.doi.org/10.22270/jddt.v11i1.4633.
Full textAbstract:
Lamotrigine is a newer anti-epileptic drug synthesised in 1980s and approved by USFDA in 1994. It is mainly used for treating paediatric epilepsy and one of the frequently prescribing newer anti- epileptic drugs in European countries. In English scenario, lamotrigine is suggested as monotherapy for recently identified partial seizures (localized seizure) in children as its first line drug. Lamotrigine is recommended for generalized seizures as second line drug and as add on therapy in intractable generalized epilepsy. It is a treatment option after sodium valproate and ethosuximide for petit-mal epilepsy. It can be used as either single or in combination with other anti-epileptic drugs. It has lot of adverse effects like other anti-epileptic drugs. Major adverse effect associated with lamotrigine is skin rashes in newly administered patients up to 8 weeks. About 3-10 % of the patients experience skin rashes in their therapy with lamotrigine. Lamotrigine doses should be titrated properly in combination with other anti-epileptic drugs especially with valproic acid. Other less common adverse effects with lamotrigine include dizziness, ataxia, blurred vision, headache, nausea and diplopia. Moreover, lamotrigine has a safe drug profile and effective in both children and adults for the treatment of various types of seizures. The dose escalation should be monitored regularly to avoid serious adverse reactions.
26
Weaver, Donald F. "Epileptogenesis, Ictogenesis and the Design of Future Antiepileptic Drugs." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 30, no. 1 (2003): 4–7. http://dx.doi.org/10.1017/s0317167100002353.
Full textAbstract:
ABSTRACT:There is still no medical cure for epilepsy. Clinical epileptology is in need of a “paradigm shift” when it comes to the continuing development of therapeutics. An important first step in this conceptual evolution is differentiating between the notions of ictogenesis and epileptogenesis. All traditional therapeutics are anti-ictogenic, not antiepileptogenic. The future of antiepileptic drug development lies in the discovery of antiepileptogenics. Just as aspirin is not the drug of choice for meningitis, an anticonvulsant is not the drug of choice for epilepsy. Drug design for epilepsy needs to discover a penicillin, not more aspirins.
27
Narwat, Arvind, and Vivek Sharma. "Prescription pattern of antiepileptic drugs in indoor patients at tertiary care hospital in Haryana, India." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 537. http://dx.doi.org/10.18203/2319-2003.ijbcp20180670.
Full textAbstract:
Background: Epilepsy is a challenging medical problem in India with an annual incidence of 27.27 per 100,000 population and prevalence of 572.8 per 100,000. People with epilepsy require prolonged treatment and monitoring. The main goal in the treatment of epilepsy should be adequate control of seizures, without causing any life-threatening reactions due to the medications. This study was done to get an insight into the prescription pattern of anti-epileptic drugs (AEDs) in different types of epilepsy.Methods: A prospective study was carried out for six months (Feb to June 2016) in admitted patients in super speciality ward (Lala Shyam Lal) in neurology department of PGIMS, Rohtak, Haryana. The prescription data of 100 patients of seizures was analysed.Results: Idiopathic generalised epilepsy was commonest type of epilepsy (42%) and sodium valproate was the commonest drug prescribed for its treatment (66.66%) followed by phenytoin (23.33%) Symptomatic epilepsy was second commonest seizure (30%) and phenytoin (60%) was the commonest drug prescribed for it followed by sodium valproate (30%). Common adverse effects associated with anti-epileptic drugs (AEDs) were nausea, drowsiness, weight gain, diplopia and ataxia.Conclusions: Idiopathic generalized epilepsy was the commonest type of epilepsy recorded and sodium valproate was the commonest prescribed drug.
28
Opiyo, Sylvia Awino. "Herbal Extracts Exhibit Anti-Epilepsy Properties." IOSR Journal of Applied Chemistry 17, no. 11 (2024): 09–23. http://dx.doi.org/10.9790/5736-1711010923.
Full textAbstract:
Epilepsy refers to a group of persistent neurological illnesses characterized by seizures. It is a chronic brain disease that affects 50 million people in the world, being one of the most common neurological disorders. Developing countries account for over 90% of all epilepsy patients. Epileptic seizures are caused by aberrant, excessive, or hyper synchronized neuronal activity in the brain. The cause of most epileptic seizures is unknown. However, some people develop epilepsy as a result of a brain injury, stroke, brain tumor, or drug and alcohol abuse. Anti-seizure drugs remain the mainstay in the treatment of epilepsy and about 70% of epileptics become seizure-free when antiseizure medications are taken effectively. However, some of these medications have significant pharmacological interactions and undesirable side effects. Traditional utilization of plants extracts for treatment of epilepsy is widely practiced. Many plants extracts and herbal formulations have been studied to determine their efficacy in treatment of epilepsy. This paper presents a review on herbal extracts that have shown antiepileptic activity in animal models published in the last ten years (between 2014 and 2024). The study found that plant extracts from some 138 plant species belonging to 54 different plant families were evaluated for antiepileptic efficacy. The most studied plants belong to the Asteraceae family (19%) followed by Fabaceae (9%), Apiaceae (8%), Lamiaceae (8%), Apocynaceae (7%), Cucurbitaceae (3%), Euphorbiaceae (3%) and Rutaceae (3%). In most cases, the studies focused only on the crude extracts without any attempts to identify the antiepileptic compounds from the plants. The most commonly used model in the antiepileptic assays were found to be pentylenetetrazole and maximal electroshock models. The findings from this study confirm that plant extracts have significant efficacy that needs to be explored for antiepileptic formulation and drugs development. It is also necessary to perform bioassay guided phytochemical evaluation to isolate and characterize the antiepileptic principles.
29
Lebedeva, A. V., S. G. Burd, P. N. Vlasov, et al. "Treatment of epilepsy associated with primary and metastatic brain tumors." Epilepsy and paroxysmal conditions 13, no. 3 (2021): 286–304. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2021.099.
Full textAbstract:
There is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features of clinically manifested epilepsy at varying stages of BTs, aspects of drug-drug interaction between AEDs and anti-tumor agents, AED-related effects on cognitive functions as well as quality of life in patients with epilepsy associated with BTs. Levetiracetam and valproic acid comprise the first-line drugs for treating seizures in patients with BTs. It is unreasonable to use AEDs acting as hepatic microsomal enzyme inducers for therapy of epileptic seizures in BTs, because it may decrease efficacy of chemotherapy agents and glucocorticoids along with elevated rate of side effects. Perampanel acting as a selective noncompetitive AMPA receptor antagonist, may be one of the drugs of choice for the adjunctive therapy of epileptic seizures associated with BTs.
30
Lee, Seung Cheol, Hyeon Don Hong, Hyun Kyo Lim, and Seung Woo Song. "Total intravenous anesthesia with remimazolam in a patient with epilepsy who underwent deep brain stimulation: a case report." Journal of the Korean Society of Stereotactic and Functional Neurosurgery 18, no. 2 (2022): 103–6. http://dx.doi.org/10.52662/jksfn.2022.00241.
Full textAbstract:
Drugs administered for anesthesia can trigger seizure attacks in patients with epilepsy. Benzodiazepines have been consistently reported to be anticonvulsants, and a novel benzodiazepine, remimazolam, was recently introduced. We report a case of total intravenous anesthesia maintained with remimazolam in a patient with epilepsy who underwent deep brain stimulation of both anterior thalamic nuclei. Despite the administration of multiple anti-epileptic drugs, no tolerance to remimazolam was observed. Perioperative seizures were also not observed. Remimazolam can be considered the anesthetic of choice in patients with epilepsy.
31
Abd El Dayem, Soha M., Osama N. Saleh, Nahed A. Emara, Manal E. Kandil, Rania H. Shatla, and Sara Elgammal. "Evaluation of Homocysteine, Folic Acid and Vitamin B12 Levels among Egyptian Children with Idiopathic Epilepsy." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (2014): 109–13. http://dx.doi.org/10.3889/oamjms.2014.019.
Full textAbstract:
Objective: To evaluate relationship between homocysteine (Hcy), folic acid and vitamin B12 with anti-epileptic drugs in epileptic patients and their role in epilepsy control.Patient and Methods: The study included 60 patients with idiopathic epilepsy and thirty non-epileptic children of the same age and sex served as controls. All cases were subjected to physical and neurological examination and electroencephalogram (EEG). Serum level of folic acid, homocysteine (Hcy) and vitamin B12 were done for both epileptic patients and controls. Non parametric test, one way ANOVA and Pearson’s correlation were used for analysis of data.Result: 44 patients (73.3%) had generalized epilepsy and the remaining patients had partial epilepsy (simple or complex). 37 patients (61.6%) were in grade I, 3 patients (5 %) were in grade II and the remaining 20 patients (33.3 %) were in grade III epilepsy. Vitamin B12 was significantly higher in epileptic patients. Duration of anti-epileptic drug treatment was correlated significantly to folic acid and Hcy level.Conclusion: antiepileptic drugs might upset the homeostatic balance of Hcy and its cofactors and cause abnormalities of their serum levels. The duration of anti-epileptic drug treatment was related to decrease of folic acid and increase in homocysteine levels.
32
Saraswati, Putu Dewinadya. "Characteristics of Epilepsy Outpatients Sufferer at Bali Mandara Hospital in January - December 2019." E-Jurnal Medika Udayana 11, no. 1 (2022): 25. http://dx.doi.org/10.24843/mu.2022.v11.i01.p05.
Full textAbstract:
Background: Epilepsy is one of the chronic neurologic disease that often found the cases. Epilepsy is a global health issue that affected 50 million people around the world Objective: This study aims to determine the characteristics of epilepsy outpatients in Bali Mandara Regional Hospital in January-December 2019. Method: The method used in this study was a cross sectional descriptive study using secondary data of patient medical records. Obtained data that met the inclusion criteria was 149. Data analyzed by using SPSS 20 program. Results: The most frequent age category is 0-17 years about 57%, more often in male about 51%, dominant etiology is idiopathic about 65,8%, the most common type of seizure was generalize about 69.8%, anti-epileptic drugs that frequently used was carried out in the form of monotherapy about 50,3%. Conclusion: The most common age category is 0-17 years, male slightly more than female, idiopathic epilepsy is more frequently happened, most common type of seizure was generalized, monotherapy and polytherapy anti-epileptic drugs is almost the same but primarily in the form of monotherapy is the most received by the patients
 Keywords: epilepsy, characteristics, anti epileptic drug
33
Nanoti, Girish, Shantanu Shembalkar, and Prafulla Shembalkar. "Use of Paediatric Epilepsy Side Effects Questionnaire (PESQ) for Early Detection of Adverse Effects of Anti-Epileptic Drugs in Children with Epilepsy." Indian Journal of Trauma and Emergency Pediatrics 8, no. 2 (2016): 85–94. http://dx.doi.org/10.21088/ijtep.2348.9987.8216.8.
Full text
34
Wang, Wei. "Advance on synthesis, pharmacokinetics, and pharmacodynamics of the anti-epileptic drug: Levetiracetam." E3S Web of Conferences 185 (2020): 03006. http://dx.doi.org/10.1051/e3sconf/202018503006.
Full textAbstract:
Over the past few decades, many patients around the world have suffered from epilepsy, and epilepsy treatment is a long-term process. Thus, the safety and efficacy of medication for epilepsy are of equal importance. Levetiracetam is a second-generation anti-epileptic drug with a unique mechanism of action, good anti-epileptic efficacy, and safety. The therapeutic field has broad application prospects because levetiracetam offers several advantages over other anti-epileptic drugs. In this review, the synthesis, pharmacokinetics, pharmacodynamics, and reverse reaction of levetiracetam were summarized and discussed. This paper will be helpful for the development and application of levetiracetam.
35
Suwasanti, Niluh, Aryati Aryati, Darto Saharso, and Ferdy Royland Marpaung. "CORRELATION OF VITAMIN D AND CALCIUM LEVELS IN CHILDREN IN NEW DIAGNOSED EPILEPSY AND MINIMAL 6 MONTHS AFTER THERAPY." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 46. http://dx.doi.org/10.24293/ijcpml.v26i1.1348.
Full textAbstract:
INTRODUCTION. Children with epilepsy should take long-term anti-epileptic drugs. Long-term use of anti-epileptic drugs can reduce vitamin D levels. Low vitamin D will lead to low blood calcium levels. This study aims to analyze the relationship between vitamin D and calcium levels in newly diagnosed epileptic children and ≥6 months after therapy. METHOD. These was an analytical observational study with cross sectional research design. The vitamin D examination instrument uses the ELFA method (enzyme linked fluorescent assay) with the Vidas instrument from bioMerieux. Samples were collected during June - August 2018 from Inpatient and Outpatient Clinics. The samples were divided into new diagnosis of epilepsy group and 6 months after therapy group. Each group was measured for vitamin D and serum calcium levels. The relationship between the two parameters were analyzed using T-Test independent. RESULTS. From the 19 new diagnosis of epilepsy, there were 57.9% low vitamin D and 10.5% low calcium levels. From the 20 subjects 6 months after therapy, 70% low vitamin D and 25% low calcium levels. There were a relationship between vitamin D and calcium levels in patients with newly diagnosed and ≥6 months after therapy. DISCUSSION. Low vitamin D and low calcium levels were found more in the anti-epileptic therapy group than the new diagnosis group of epilepsy. Low vitamin D levels can be caused by the use of long-term antiepileptic drugs that will affect serum calcium levels. CONCLUSION. This study showed a significant relationship between vitamin D and serum calcium levels in patients with newly diagnosed epilepsy and 6 months after therapy. Vitamin D and calsium serum examination should be done in every patient who gets long term therapy of antiepileptic drugs. KEY WORDS. Vitamin D, calcium, epilepsy, ELFA.
36
Silvestro, Serena, Santa Mammana, Eugenio Cavalli, Placido Bramanti, and Emanuela Mazzon. "Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials." Molecules 24, no. 8 (2019): 1459. http://dx.doi.org/10.3390/molecules24081459.
Full textAbstract:
Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.
37
Delen, Dursun, Behrooz Davazdahemami, Enes Eryarsoy, Leman Tomak, and Abhinav Valluru. "Using predictive analytics to identify drug-resistant epilepsy patients." Health Informatics Journal 26, no. 1 (2019): 449–60. http://dx.doi.org/10.1177/1460458219833120.
Full textAbstract:
Epilepsy is one of the most common brain disorders that greatly affects patients’ quality of life and poses serious risks to their health. While the majority of the patients positively respond to the existing anti-epilepsy drugs, others who developed the refractory type of epilepsy show resistance against drug therapy and need to undergo advance treatments such as surgery. Given that identifying such patients is not a straightforward process and requires long courses of trial and error with anti-epilepsy drugs, this study aims at predicting those at-risk patients using clinical and demographic data obtained from electronic medical records. Specifically, the study employs several predictive analytics machine-learning methods, equipped with a novel approach for data balancing, to identify drug-resistant patients using their comorbidities and demographic information along with the initial epilepsy-related diagnosis made by their physician. The promising results we obtained highlight the potential use of machine-learning techniques in facilitating medical decisions and suggest the possibility of extending the proposed approach for developing a clinical decision support system for medical professionals.
38
Machmoed, Hadia Anggriani, Nadya A. R. Bubakar, Urfianty Urfianty, and Idham Jaya Ganda. "CORRELATION BETWEEN THE DURATION OF ANTI-EPILEPTIC DRUGS THERAPY AND VITAMIN D LEVEL IN EPILEPTIC CHILDREN." International Journal of Health Science & Medical Research 2, no. 1 (2022): 1–10. http://dx.doi.org/10.37905/ijhsmr.v2i1.14286.
Full textAbstract:
Long-term use of antiepileptic drugs (AEDs) for epilepsy causes a decrease in vitamin D levels due to the activation of liver cytochrome P450 enzymes. The novelty of this study is due to researching about correlation between the duration of anti-epileptic drugs therapy and vitamin d level in epileptic children This cross-sectional study was conducted from October - December 2021in children with epilepsy aged 1 month to 18 years admitted to pediatric neurology polyclinic of DR Wahidin Sudirohusodo. They were divided into two groups: epileptic children receiving AEDs treatment ≤ 1 year and epileptic children receiving AEDs treatment 1 year. Statistical analysis showed no significant relationship between the duration of AEDs use and the incidence of vitamin D deficiency in children with epilepsy.Keywords: Vitamin D Deficiency; Antiepileptic Drugs; Epilepsy
39
Francois, Xavier Ndayambaje, Natukunda Bernard, and Bosco Gahutu Jean. "Prevalence of Metabolic Syndrome amongst Rwandan Patients with Epilepsy." Pharmaceutical and Chemical Journal 7, no. 4 (2020): 43–52. https://doi.org/10.5281/zenodo.13955239.
Full textAbstract:
Cardiovascular mortality and morbidity are more frequent in people with epilepsy than in general population. The explanation of that may be the change in biochemical components due to anti-epileptic drugs. We conducted this study to determine the prevalence of metabolic syndrome (MetS) and risk factors in adults with epilepsy emphasizing on respective anti-epileptic drugs patients were using. <strong><em>Method:</em></strong> This was a cross-sectional study conducted from December 2018 to December 2019 in patients with epilepsy aged 18-60 years old who were on anti-epileptic drugs for at least two years. 1076 adult patients with epilepsy were selected to participate in this study. Participants were anthropometrically examined and fasting blood glucose and lipids were assayed. The study was conducted at Ndera Neuropsychiatric Hospital-CARAES Ndera in Rwanda. <strong><em>Results:</em></strong> The final participant pool included 669 males, 58.5% and 447 females, 41.5%. The mean age of participants was 40.22±10.37 that of males was 40.20.04±10.34 and of females was 40.24.04±10.42. Using ATP III criteria, the crude prevalence of metabolic syndrome in people with epilepsy was 30.6% (329 subjects) and patients without metabolic syndrome were 747 (69.4%). Use of valproic acid (<em>p</em>=0.007), sedentary lifestyle (<em>p</em>=0.025), waist circumference>102cm (<em>p</em>=0.001), high triglycerides (<em>p</em>=0.001), high blood pressure (<em>p</em>=0.001), and fasting blood glucose >6.1mmol (<em>p</em>=0.001) were significantly associated with metabolic syndrome. <strong><em>Conclusion:</em></strong> The MetS is highly prevalent among patients with epilepsy
40
Packer, R. M. A., N. K. Shihab, B. B. J. Torres, and H. A. Volk. "Responses to successive anti-epileptic drugs in canine idiopathic epilepsy." Veterinary Record 176, no. 8 (2015): 203. http://dx.doi.org/10.1136/vr.102934.
Full text
41
Łukasiuk, Katarzyna, and Władysław Lasoń. "Emerging Molecular Targets for Anti-Epileptogenic and Epilepsy Modifying Drugs." International Journal of Molecular Sciences 24, no. 3 (2023): 2928. http://dx.doi.org/10.3390/ijms24032928.
Full textAbstract:
The pharmacological treatment of epilepsy is purely symptomatic. Despite many decades of intensive research, causal treatment of this common neurologic disorder is still unavailable. Nevertheless, it is expected that advances in modern neuroscience and molecular biology tools, as well as improved animal models may accelerate designing antiepileptogenic and epilepsy-modifying drugs. Epileptogenesis triggers a vast array of genomic, epigenomic and transcriptomic changes, which ultimately lead to morphological and functional transformation of specific neuronal circuits resulting in the occurrence of spontaneous convulsive or nonconvulsive seizures. Recent decades unraveled molecular processes and biochemical signaling pathways involved in the proepileptic transformation of brain circuits including oxidative stress, apoptosis, neuroinflammatory and neurotrophic factors. The “omics” data derived from both human and animal epileptic tissues, as well as electrophysiological, imaging and neurochemical analysis identified a plethora of possible molecular targets for drugs, which could interfere with various stages of epileptogenetic cascade, including inflammatory processes and neuroplastic changes. In this narrative review, we briefly present contemporary views on the neurobiological background of epileptogenesis and discuss the advantages and disadvantages of some more promising molecular targets for antiepileptogenic pharmacotherapy.
42
Kotov, A. S., and K. V. Firsov. "Epilepsy in mitochondrial diseases. Clinical lecture." Russian Journal of Child Neurology 17, no. 4 (2023): 63–70. http://dx.doi.org/10.17650/2073-8803-2022-17-4-63-70.
Full textAbstract:
Mitochondrial dysfunction mainly affects organs with high metabolic demand, primarily the brain. Epilepsy is a common phenotypic sign of both syndromic and non-syndromic mitochondrial diseases. Epilepsy in mitochondrial diseases is poorly treatable and is often an unfavorable prognostic sign. Patients with mitochondrial epilepsy are prescribed various anti-seizure medications. Mitochondriotoxic drugs should be avoided. Descriptions of MELAS-syndrome, MERRF-syndrome, Leigh-syndrome, NARP-syndrome are given.
43
Bhardwaj, Ankit, Anand Shukla, Sunita Singh, and Anil Kem. "Cyproheptadine adverse drug interaction with anti-epileptic drugs." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 577. http://dx.doi.org/10.18203/2319-2003.ijbcp20180677.
Full textAbstract:
Cyproheptadine is a H1 and 5- HT1/2 receptor antagonists, impairing the anticonvulsant activity of antiepileptic drugs and reduces threshold, increases severity of seizures, when administered chronically. Anuj a 13 years old male from Delhi, known case of SSPE stage-III with epilepsy, on oral anti-epileptic drug has seizure induction followed the use of oral cyproheptadine. Stopping cyproheptadine, patient didn’t sustain any further seizures.
44
Madireddy, Sahithi, and Samskruthi Madireddy. "Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation." Brain Sciences 13, no. 5 (2023): 784. http://dx.doi.org/10.3390/brainsci13050784.
Full textAbstract:
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures that affects 50 million individuals globally. Because approximately one-third of patients with epilepsy do not respond to drug therapy, the development of new therapeutic strategies against epilepsy could be beneficial. Oxidative stress and mitochondrial dysfunction are frequently observed in epilepsy. Additionally, neuroinflammation is increasingly understood to contribute to the pathogenesis of epilepsy. Mitochondrial dysfunction is also recognized for its contributions to neuronal excitability and apoptosis, which can lead to neuronal loss in epilepsy. This review focuses on the roles of oxidative damage, mitochondrial dysfunction, NAPDH oxidase, the blood–brain barrier, excitotoxicity, and neuroinflammation in the development of epilepsy. We also review the therapies used to treat epilepsy and prevent seizures, including anti-seizure medications, anti-epileptic drugs, anti-inflammatory therapies, and antioxidant therapies. In addition, we review the use of neuromodulation and surgery in the treatment of epilepsy. Finally, we present the role of dietary and nutritional strategies in the management of epilepsy, including the ketogenic diet and the intake of vitamins, polyphenols, and flavonoids. By reviewing available interventions and research on the pathophysiology of epilepsy, this review points to areas of further development for therapies that can manage epilepsy.
45
Zhang, Liang, Hao Yu, Dan Li, Hui Qian, and Yuchao Chen. "Spermatorrhea in a Chinese patient with temporal lobe epilepsy: a case report." Journal of International Medical Research 49, no. 1 (2021): 030006052098281. http://dx.doi.org/10.1177/0300060520982814.
Full textAbstract:
Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile dysfunction and premature ejaculation in men. In this study, we report the case of a 65-year-old Chinese man with frequent spermatorrhea. Electroencephalography suggested local epilepsy in the left temporal lobe. After treatment with anti-epilepsy drugs, the symptoms disappeared and did not recur. To the best of our knowledge, this is the first reported case of epilepsy-induced spermatorrhea. The symptoms of spermatorrhea are probably a rare manifestation of seizure. When repetitive stereotyped symptoms occur, seizure should be considered, and tentative anti-epileptic treatment may be a good option.
46
S, Manjula, and Krishna Kumar M. "Expert Opinion on the Prescription Practice of Levetiracetam for Different Types of Epilepsy in Indian Clinical Settings." SAR Journal of Psychiatry and Neuroscience 5, no. 01 (2024): 1–6. http://dx.doi.org/10.36346/sarjpn.2024.v05i01.001.
Full textAbstract:
Despite some studies assessing antiepileptic drug usage patterns in single-centre settings, there was a lack of consensus regarding usage patterns, drug choices for various seizure types, and the sociodemographic and clinical factors that influence treatment decisions in India. So, this current survey-based study was intended to gather expert opinions regarding the clinical use of anti-epileptic drugs with a special focus on levetiracetam for the management of epilepsy in Indian settings. A questionnaire-based cross-sectional study involving 25 questions collected perspectives of experts across India regarding the prescription practice of anti-epileptic drugs for epilepsy management. It was noted that majority of the responders (85.93% of 192 experts) stated levetiracetam as a preferred therapeutic option for patients with newly diagnosed epilepsy. Levetiracetam 1000 mg/day was the frequently recommended dosage for such patients in clinical practice (66%). Approximately 76% of the experts suggested that patients receiving the drug might experience behavioural changes. About 49% and 82% of responders recommended levetiracetam for treating resistant epilepsy and pregnant epilepsy respectively. Nearly 62% of the clinicians recommended levetiracetam for paediatric patients with partial seizures over other antiepileptic drugs. Levetiracetam and brivaracetam were both rated as beneficial for treating epileptic patients by 50% of clinicians. Levetiracetam was rated as being more effective than brivaracetam by 28% of clinicians, while brivaracetam was rated as being more effective by 14% of clinicians. Hence, this consensus among clinician’s highlights levetiracetam as the preferred antiepileptic medication for the management of patients with recently diagnosed epilepsy. This recommendation extends patients with refractory epilepsy, pregnant subjects with epilepsy, and young children experiencing partial seizures, where the majority of the clinicians endorse levetiracetam over alternative antiepileptic medications. Both levetiracetam and brivaracetam offer comparable treatment benefits for patients with epilepsy.
47
Cen, Xinyu. "Advances in Drug Treatment of Refractory Epilepsy." Theoretical and Natural Science 70, no. 1 (2024): 97–103. https://doi.org/10.54254/2753-8818/2024.18243.
Full textAbstract:
Refractory epilepsy is a nervous system disease that does not respond well to conventional anti-epileptic drugs, and has always been a difficult problem to be solved in the medical field. The purpose of this paper is to comprehensively review and analyze the current progress of drug therapy for refractory epilepsy, in order to provide reference for future clinical practice and research. In this paper, the definition, classification, pathogenesis and mechanism of refractory epilepsy were summarized. Subsequently, the application and limitations of traditional antiepileptic drugs, as well as the development and clinical application of new antiepileptic drugs, such as CBD and P2X7R, were discussed in detail. This paper looks forward to the future research direction and challenges, focusing on the trends and challenges of new drug development, as well as the application prospects of precision medicine in the treatment of refractory epilepsy. Finally, it is pointed out that the future treatment of refractory epilepsy still needs to face the technical maturity of advanced technology in practical application, and the development of new drugs and new treatments requires a lot of money and time investment, and clinical trials may fail.
48
Ashraf, Hamid, Lubna Zafar1, and Damera Achyut Kumar1. "Abstract 76: Alteration in bone metabolism and bone mineral density with chronic anti-epileptic drug therapy in North Indian population." Indian Journal of Endocrinology and Metabolism 26, Suppl 1 (2022): S30. http://dx.doi.org/10.4103/2230-8210.342197.
Full textAbstract:
Objective: Anti-epileptic drugs are the mainstay of treatment of epilepsy. Prolong use of anti-epileptic medicines can lead to reduction in bone mineral density (BMD), resulting in 2-6-fold increase in fracture risk. This study was carried out to assess the impact of AEDs on the markers of bone turnover and BMD in North Indian patients. Methods: In this hospital based observational study sixty adult patients with epilepsy, on antiepileptic drugs were included. Serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, 25 (OH) vitamin D and intact Parathyroid hormone (iPTH) and BMD (at lumbar spine with DEXA) were measured in all study subjects. Results: The serum level of calcium, phosphorus and 25(OH) Vitamin D was significantly decreased and iPTH and ALP levels were increased in patients taking anti-epileptic drugs for > 5 years. There was a significant negative correlation between serum calcium, phosphorus and vitamin D levels and significant positive correlation with ALP and iPTH levels with duration anti-epileptic therapy. There was negative correlation between the T-score and anti-duration of anti-epileptic therapy. Conclusions: Use of anti-epileptic (both old and new) medication in adults is associated with decline in BMD, calcium, vitamin D and phosphorus levels and elevation in iPTH and ALP levels.
49
Halil, Halit, Nilden Tuygun, Erhan Aksoy, Ozcan Erel, and Can Demir Karacan. "Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients." Combinatorial Chemistry & High Throughput Screening 22, no. 1 (2019): 65–68. http://dx.doi.org/10.2174/1386207322666190305135043.
Full textAbstract:
Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body. Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients. Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and native thiol/ total thiol ratios were calculated. Hence, the ratios of disulfide/ native thiol, disulfide / total thiol and native thiol/ total thiol were calculated. Results: Serum levels of native thiol, total thiol and disulfide were significantly lower in the epilepsy group than the control group. The ratio of disulfide/native thiol and disulfide / total thiol were significantly higher in the study group than the control group. As well as, the native thiol / total thiol ratio was lower in the epilepsy group than the control group. Native thiol, total thiol and disulfide were significantly lower in the epilepsy group who were taking anti-epileptic drugs than those who were not taking anti-epileptic drugs. Conclusion: We demonstrated a meaningful relationship between oxidative stress markers and epilepsy in pediatric patients.
50
Fernández‐Torre, José L., Javier Riancho, María Martín‐García, Gonzalo Martínez‐de las Cuevas, and Pilar Bosque‐Varela. "Tonic status epilepticus in a centenarian woman." Epileptic Disorders 21, no. 1 (2019): 92–96. http://dx.doi.org/10.1684/epd.2019.1031.
Full textAbstract:
ABSTRACT Generalized tonic status epilepticus (TSE) is a rare epileptic condition. It occurs usually in the context of symptomatic generalized epilepsy, in particular, in subjects with a diagnosis of Lennox‐Gastaut syndrome, atypical forms of idiopathic (genetic) generalized epilepsy, or as a paradoxical effect during treatment with diverse antiepileptic drugs. Herein, we describe the case of an elderly woman on chronic treatment with psychotropic drugs who developed an episode of generalized TSE. Motor manifestations were subtle and difficult to recognize as seizures, and a detailed video‐EEG importantly contributed to accurate and prompt diagnosis. TSE was initially refractory to conventional anti‐seizure drug therapy including levetiracetam and valproate but was finally controlled with lacosamide. Our case indicates a potential therapeutic effect of lacosamide on TSE in the elderly after treatment failure with first‐line anti‐seizure drugs. [ Published with video sequence on www.epilepticdisorders.com ]