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Journal articles on the topic 'Anti fire hazard'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Stahler, Arndt, Dominik Paul Modest, Sebastian Stintzing, et al. "Consensus molecular subtypes (CMS) as prognostic and predictive biomarkers of RAS wild-type (WT) metastatic colorectal cancer (mCRC): Pooled analysis of the randomized trials FIRE-1, FIRE-3, XELAVIRI, and PanaMa." Journal of Clinical Oncology 42, no. 16_suppl (2024): 3529. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3529.

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3529 Background: CMS were associated with prognostic relevance in RAS WT mCRC, while their role as predictive biomarker is debatable. We aimed to assess the predictive impact of CMS on treatment with anti-EGFR vs. anti-VEGF antibodies vs. cytotoxic treatment alone in a pooled analysis. Methods: Available CMS data (called by predictedCMS method) of the randomized controlled trials FIRE-1 (FUFIRI vs. mIrOx); FIRE-3 (FOLFIRI+ cetuximab vs. bevacizumab), XELAVIRI (sequential vs. initially combined FOLFIRI+bevacizumab) and PanaMa (FOLFOX+panitumumab followed by FU/FA +/- panitumumab) of RAS WT mCRC

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Politi, Nadia, Diamando Vlachogiannis, and Athanasios Sfetsos. "A Statistical Analysis of Drought and Fire Weather Indicators in the Context of Climate Change: The Case of the Attica Region, Greece." Climate 12, no. 9 (2024): 135. http://dx.doi.org/10.3390/cli12090135.

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As warmer and drier conditions associated with global warming are projected to increase in southern Europe, the Mediterranean countries are currently the most prone to wildfire danger. In the present study, we investigated the statistical relationship between drought and fire weather risks in the context of climate change using drought index and fire weather-related indicators. We focused on the vulnerable and long-suffering area of the Attica region using high-resolution gridded climate datasets. Concerning fire weather components and fire hazard days, the majority of Attica consistently prod

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Wang, Jingyuan, Joshua Millstein, Fotios Loupakis, et al. "Genetic variants involved in the lipid metabolism pathway to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3 and MAVERICC trials." Journal of Clinical Oncology 39, no. 3_suppl (2021): 118. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.118.

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118 Background: Antiangiogenic drug (AAD)-triggered oxygen and nutrient depletion through suppression of angiogenesis switches the glucose-dependent metabolism to lipid-dependent metabolism. Blocking fatty acid oxidation can enhance AAD-mediated anti-tumor effects in colorectal cancer. Previous reports suggested that polymorphisms of the lipid metabolism-related genes are associated with the increased risk of CRC and poor clinical outcome in CRC. Therefore, we hypothesized that genetic variants in the lipid metabolism pathway may predict first-line treatment outcome in mCRC pts. Methods: Genom

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Modest, Dominik P., Sebastian Stintzing, Ludwig Fischer von Weikersthal, et al. "Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial: First-Line Therapy With FOLFIRI Plus Cetuximab or Bevacizumab in Patients With KRAS Wild-Type Tumors in Metastatic Colorectal Cancer." Journal of Clinical Oncology 33, no. 32 (2015): 3718–26. http://dx.doi.org/10.1200/jco.2015.61.2887.

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Purpose We investigated choice and efficacy of subsequent treatment, with special focus on second-line therapy, in the FIRE-3 trial (FOLFIRI plus cetuximab [arm A] or bevacizumab [arm B]) for patients with KRAS wild-type metastatic colorectal cancer. Patients and Methods Start of subsequent-line (second or third) therapy was defined as use of an antitumor drug that was not part of the previous regimen. We evaluated choice, duration, and efficacy of subsequent therapy and determined the impact of subsequent-line treatment on outcome of patients in FIRE-3. Results Of 592 patients in the intent-t

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Rizal Mi’raz, Ade Irma Wantini, and Ganis Sanhaji. "Internet of Things Menggunakan Platform Realtime Data base Berbasis Aplikasi Android dan Google Voice Asistant untuk Alarm Anti Begal." TEMATIK 10, no. 1 (2023): 34–40. http://dx.doi.org/10.38204/tematik.v10i1.1288.

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Abstract Recently there have been many cases of spoliation and motorbike theft in various cities throughout Indonesia. Spoliation occurs regardless of time and place. One of the preventive efforts is to create a system that can improve the motorcycle security system by using the Internet of Things (IoT). This article will discuss the use of IoT technology to help the safety and security of motorists, as well as motorbikes by designing an anti-theft alarm prototype. This alarm has the intelligence to force perpetrators of motorcycle robbery or theft to thwart their actions with vibration

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Modest, Dominik Paul, Sebastian Stintzing, Ludwig Fischer von Weikersthal, et al. "Time-course evaluation of survival and treatment in FIRE-3 (AIO KRK0306, first-line therapy of KRAS wild-type metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab)." Journal of Clinical Oncology 34, no. 4_suppl (2016): 617. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.617.

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617 Background: FIRE-3 reported overall survival (OS) difference in favour of arm A (FOLFIRI plus cetuximab, N= 297 pts.) compared to arm B (FOLFIRI plus bevacizumab, N= 295 pts.) in the absence of significant differences in progression-free survival and response rate. Methods: We subdivided the study into six-month time intervals, starting at the time point of randomisation and evaluated OS in a time-wise fashion. Within each interval, OS was analyzed by Cox regression. Furthermore, systemic treatment and local interventions were investigated in the respective time-frames. Results: The time-c

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Yamazaki, Kentaro, Yuriko Takeda, Toshihiro Misumi, et al. "Optimal molecular-targeted therapies as first-line treatment for RAS wild-type, right-sided metastatic colorectal cancer from the Analysis and Research in Cancers of the Digestive System (ARCAD) database." Journal of Clinical Oncology 41, no. 16_suppl (2023): 3588. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.3588.

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3588 Background: Although anti-EGFR antibody plus doublet chemotherapy has become the standard of first-line treatment for RAS wild-type (wt), left sided metastatic colorectal cancer (mCRC), the optimal molecular-targeted therapy for RAS wt, right-sided mCRC is not clear. Methods: To evaluate the efficacy between anti-EGFR antibody vs. bevacizumab combination therapy, from 40,889 Individual patient (pt) data from 59 studies in ARCAD mCRC database, 723 pts with RAS wt, right-sided mCRC who received a first-line molecular-targeted therapy with backbone chemotherapy (FOLFOX/FOLFIRI when anti-EGFR

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Гойкалов, Г. Г., А. А. Абашкин, Д. В. Ушаков, and С. Г. Панфилов. "Issues of ensuring timely evacuation of people from buildings of educational organizations." Pozharnaia bezopasnost`, no. 3(104) (October 5, 2021): 71–79. http://dx.doi.org/10.37657/vniipo.pb.2021.28.94.008.

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Статья посвящена проблеме противопожарной защиты объектов просвещения с учетом требований Федерального закона «Технический регламент о требованиях пожарной безопасности», постановления Правительства Российской Федерации, которым утверждены Правила проведения расчетов по оценке пожарного риска. Рассмотрены вопросы определения необходимого времени эвакуации людей из общеобразовательных организаций при пожаре. Проанализированы требования нормативных правовых документов в области пожарной безопасности. The article is devoted to the actual topic of providing conditions for the safe evacuation of pe

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Гойкалов, Г. Г., А. А. Абашкин, Д. В. Ушаков, and С. Г. Панфилов. "Issues of ensuring timely evacuation of people from buildings of educational organizations." Pozharnaia bezopasnost`, no. 3(104) (October 5, 2021): 71–79. http://dx.doi.org/10.37657/vniipo.pb.2021.28.94.008.

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Статья посвящена проблеме противопожарной защиты объектов просвещения с учетом требований Федерального закона «Технический регламент о требованиях пожарной безопасности», постановления Правительства Российской Федерации, которым утверждены Правила проведения расчетов по оценке пожарного риска. Рассмотрены вопросы определения необходимого времени эвакуации людей из общеобразовательных организаций при пожаре. Проанализированы требования нормативных правовых документов в области пожарной безопасности. The article is devoted to the actual topic of providing conditions for the safe evacuation of pe

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Kim, Teak-Keon, Seul-Kee Kim, and Jae-Myung Lee. "Dynamic Response of Drill Floor Considering Propagation of Blast Pressure Subsequent to Blowout." Applied Sciences 10, no. 24 (2020): 8841. http://dx.doi.org/10.3390/app10248841.

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Explosions and fire have very critical safety hazard impacts on offshore oil and gas facilities since they are mostly located in remote areas and could induce serious environmental issues. Explosion risk assessment and structure blast analysis are essential for these production facilities, and research studies have been carried out. Explosion due to blowout during drilling operation is also a critical risk for drilling units, and this has not been researched much until the accident of the drilling unit in the Gulf of Mexico in 2010. This paper provides the risk and evaluation of explosion and

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Tregubov, Dmytro, Evgen Slepuzhnikov, Maryna Chyrkina, and Artem Maiboroda. "Cluster Mechanism of the Explosive Processes Initiation in the Matter." Key Engineering Materials 952 (August 18, 2023): 131–42. http://dx.doi.org/10.4028/p-lzz2hq.

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The relationship between substance characteristic temperatures: autoignition, melting, flash, boiling is demonstrated and analyzed. Based on the oscillatory and step changes presence, a conclusion was made about the supramolecular structures presence and periodicity in the n-alkanes homologous series. A method for modeling equivalent lengths of peroxide supramolecular structures for predicting the explosion and fire hazard parameters of n-alkanes is proposed. An approximation dependence was developed for predicting autoignition temperatures tai of n-alkanes. It is shown that stoichiometric con

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Wang, Jingyuan, Yi Xiao, Fotios Loupakis, et al. "Genetic variants involved in the cGAS-STING pathway to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3 and TRIBE trials." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3535. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3535.

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3535 Background: The intracellular DNA sensor stimulator of interferon genes (STING) plays a vital role in anti-tumor immune responses by recognition of self-DNA from tumors and by-products of genomic instability. Activation of STING was reported to enhance cetuximab mediated natural killer cell activation and dendritic cell maturation. Previous reports suggested that polymorphisms of cGAS-STING can affect innate immune response. Therefore, we hypothesized that genetic variants in the cGAS-STING pathway may predict first-line treatment outcome in mCRC pts treated with bevacizumab/cetuximab-bas

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Yoshino, Takayuki, Hiroyuki Uetake, Katsuya Tsuchihara, et al. "PARADIGM study: A multicenter, randomized, phase III study of 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab or bevacizumab as first-line treatment in patients with RAS (KRAS/NRAS) wild-type metastatic colorectal cancer." Journal of Clinical Oncology 34, no. 4_suppl (2016): TPS776. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.tps776.

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TPS776 Background: Optimal combination of monoclonal antibody (anti-VEGF vs. anti-EGFR antibody) with standard chemotherapy as first-line treatment in patients (pts) with RAS (KRAS/NRAS) wild-type metastatic colorectal cancer (mCRC) remains controversial. FIRE-3 study demonstrated a significant improvement in overall survival (OS) with anti-EGFR over bevacizumab in pts with KRAS exon 2 wild type mCRC, while CALGB 80405 study did not. PARADIGM study is designed to compare panitumumab vs. bevacizumab combined with mFOLFOX6 in pts with RAS wild-type chemotherapy-naive mCRC. Methods: Eligible pts

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Wang, Jingyuan, Joshua Millstein, Fotios Loupakis, et al. "The role of PP2A variants to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3 and TRIBE trials." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3581. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3581.

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3581 Background: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase with functions that counter-balance kinase-mediated phosphorylation throughout cell signaling networks. PP2A was reported to upregulate the angiogenesis, while negatively regulate the pathways downstream of receptor tyrosine kinases at multiple nodes. Previous studies showed PP2A variants were associated with the increased risk of cancer. Therefore, we hypothesized that PP2A variants may predict first-line treatment outcome in mCRC pts treated with bevacizumab (bev)/cetuximab (cet)-based chemotherapy. Methods: Gen

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Battaglin, Francesca, Hiroyuki Arai, Joshua Millstein, et al. "Single nucleotide polymorphisms (SNPs) in endoplasmic reticulum (ER) stress response genes to predict first-line treatment outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from the MAVERICC and FIRE-3 trials." Journal of Clinical Oncology 39, no. 3_suppl (2021): 103. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.103.

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103 Background: ER stress, triggered by the disruption of intracellular protein homeostasis, promotes the activation of a highly conserved adaptive program called unfolded protein response (UPR). UPR signaling has been reported to contribute to tumor initiation and progression, as well as microenvironment remodeling and chemoresistance in multiple cancer types, including CRC. Several studies point to a direct role of the UPR in tumor angiogenesis and an interaction with EGFR signaling. We therefore hypothesized that genetic variants in ER stress response genes may predict first-line treatment

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Holch, Julian Walter, Sebastian Stintzing, Swantje Held, et al. "Right-sided colorectal cancer (RC): Response to first-line chemotherapy in FIRE-3 (AIO KRK-0306) with focus on early tumor shrinkage (ETS) and depth of response (DpR)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 3586. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3586.

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3586 Background: Recent evidence suggests that benefit from anti-EGFR treatment is restricted to RAS wild-type left-sided colorectal cancer (LC) (Holch JW et al. Eur J Cancer 2017). However, these results are preliminary. We therefore investigated patients with RC enrolled in the FIRE-3 trial, which evaluated the efficacy of first-line FOLFIRI plus either cetuximab (cet) or bevacizumab (bev) in RAS wildtype mCRC. New metrics of tumor dynamics were used to characterize the patients. Methods: The splenic flexure was used to differentiate LC from RC. Survival analysis was done using Kaplan-Meier

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Yoon, Seo Yeon, Seok-Jae Heo, Yong Wook Kim, Seung Nam Yang, and Hyun Im Moon. "Ankylosing Spondylitis: A Risk Factor for Parkinsonism—A Nationwide Population-Based Study." Journal of Parkinson's Disease 12, no. 1 (2022): 353–60. http://dx.doi.org/10.3233/jpd-212878.

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Background: Ankylosing spondylitis (AS) is an immune-mediated, chronic inflammatory rheumatic disorder. The etiology of Parkinson’s disease (PD) is multifactorial; however, inflammation is receiving an increasing amount of attention as an underlying cause of the neurodegenerative process of PD. Objective: We performed a nationwide longitudinal, population-based matched cohort study to assess the association with the later development of parkinsonism in Korea. Methods: This study was conducted using records from the Health Insurance Review and Assessment Service database. The cumulative inciden

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Tromiadis, Ramona, and Costel Stanca. "Comparative Analysis of Tanker Ships Incidents and their Environment Impacts." Advanced Materials Research 837 (November 2013): 775–79. http://dx.doi.org/10.4028/www.scientific.net/amr.837.775.

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The paper presents a comparative analysis of tanker ships incidents and their environment impacts. The focus is on oil tankers because this type of ships poses the highest environmental risk. By the sheer amount of oil carried, modern oil tankers can be considered a threat to the environment. In case of a maritime accident a ship can suffer fracture of the ships hull that may lead to oil outflow leading to environmental consequences or stability problems, which may again result in capsizing of the vessel. In terms of the consequences for the vessel maritime accidents can be classified in diffe

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Castro Carcamo, Rodolfo Antonio, and Eduardo Gutiérrez. "Volcanic monitoring and hazard assessment in El Salvador." Volcanica 4, S1 (2021): 183–201. http://dx.doi.org/10.30909/vol.04.s1.183201.

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The Salvadorean volcanic range forms part of Central America Volcanic Arc and is located on the Pacific ring of fire. El Salvador is a country with at least twenty Holocene-active volcanic structures and where most of the population, including the metropolitan area of San Salvador, live near a volcanic complex. Currently, there are six active volcanoes that are continuously monitored by the Observatorio de Amenazas y Recursos Naturales, which is part of the Ministerio del Medio Ambiente y Recursos Naturales. Volcano monitoring involves seismic, geochemical, and visual monitoring techniques, am

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Shimozaki, Keitaro, Yasutaka Sukawa, Yasunori Sato, et al. "Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data." Future Oncology 17, no. 20 (2021): 2593–603. http://dx.doi.org/10.2217/fon-2020-0861.

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The aim of this study was to determine the risk factors for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors. The authors conducted a retrospective study in which patients with malignant melanoma, non-small-cell lung cancer, gastric cancer or renal cell carcinoma who received anti-PD-1/PD-L1 antibodies were included. Of 247 patients, 118 developed a total of 182 irAEs. In the multivariate Fine–Gray regression analysis, serum albumin level ≥3.6 g/dl (hazard ratio: 1.62; 95% CI: 1.10–2.39; p = 0.015) and history of Type I hypersensitivity reactions (hazard ratio: 1.4

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Peng, Sim Yeng, Sin Yi Wen, Pang Zong Xin, et al. "Improvement of Fire Retardant Property of Natural Fiber." Applied Mechanics and Materials 471 (December 2013): 261–66. http://dx.doi.org/10.4028/www.scientific.net/amm.471.261.

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Excessive exposure to noise is harmful for human health. Noise-induced hearing loss is one prevalent disorder resulted from above case. One root solution that converts the unnecessary sound waves to dissipated heat energy is acoustic absorption panel. Previous studies had looked upon potential sound-absorbing resources corresponding to natural fiber. However, several characteristics of these biodegradable supplies such as stiffness, anti-fungus and flammability are still yet to be improved. Hence, this research was undertaken to enhance the fire retardant performance of coir fiber for the prod

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Contrera-Moreno, Luciana, Sonia Maria Oliveira de Andrade, Elenir Rose Jardim Cury Pontes, Alcione Cavalheiro Faro Stief, Maurício Antonio Pompilio, and Ana Rita Coimbra Motta-Castro. "Hepatitis B virus infection in a population exposed to occupational hazards: firefighters of a metropolitan region in central Brazil." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 4 (2012): 463–67. http://dx.doi.org/10.1590/s0037-86822012000400009.

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INTRODUCTION: By the nature of their activities, firefighters are exposed to a high risk of contracting hepatitis B virus (HBV) as most of the Fire Brigade occurrences in Campo Grande, State of Mato Grosso do Sul (MS), Brazil, are related to the rescue of victims of traffic accidents and the transportation of clinical and psychiatric emergencies. The aim of this study was to investigate the seroepidemiological profile of HBV infection in firefighters from the City of Campo Grande, central Brazil. METHODS: The research involved 308 firefighters. After giving written consent, they were interview

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GU, Lingzhu, Tianhang ZHANG, Kai ZHU, Daquan TANG, and Ke WU. "Effect of Various Metal Hydroxide Flame Retardants on the Rheological Properties of Asphalt Binder." Materials Science 25, no. 3 (2019): 348–55. http://dx.doi.org/10.5755/j01.ms.25.3.21572.

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Metal hydroxide has been widely used as flame retardant to reduce the hazards of tunnel fire, however, few researches investigate its effect on the rheological properties of asphalt binder systemically. This study explores and compares the effect and mechanisms of magnesium hydroxide (MH), aluminium hydroxide (ATH), hydrated lime (HL), and layer double hydroxides (LDHs) on the rutting resistance, anti-aging resistance, as well as the thermal cracking resistance of asphalt binder. Rotational viscosity (RV) test, dynamic shear rheometer (DSR) test, and bending beam rheometer (BBR) test are invol

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Zhou, Mingyi, Ping Yu, Kezuo Hou, et al. "Whether mCRC patients with other RAS mutations benefit from the addition of bevacizumab as first-line therapy." Journal of Clinical Oncology 34, no. 4_suppl (2016): 579. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.579.

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579 Background: It is not clear whether Bevacizumab plus chemotherapy could improve the prognosis of mCRC patients with other RAS mutations beyond KRAS exon 2. Methods: The MEDLINE, EMBASE, Cochrane databases, and Clinical Trials databases were reviewed to September 2015. The data of patients with KRAS exon 2 mutations was only available in FIRE3 study. So we could not perform the meta-analysis by KRAS exon 2 mutations. The data of patients with other RAS mutations beyond KRAS exon 2 were available in PEAK and FIRE3 studies. Hazard ratio (HR) was used to analyze the progressive-free survival (

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Zaragoza-Huesca, David, Andrés Nieto-Olivares, Francisco García-Molina, et al. "Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients." Cancers 14, no. 13 (2022): 3106. http://dx.doi.org/10.3390/cancers14133106.

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Hepsin is a type II transmembrane serine protease whose deregulation promotes tumor invasion by proteolysis of the pericellular components. In colorectal cancer, the implication of hepsin is unknown. Consequently, we aimed to study the correlations between hepsin expression and different clinical-histopathological variables in 169 patients with localized colorectal cancer and 118 with metastases. Tissue microarrays were produced from samples at diagnosis of primary tumors and stained with an anti-hepsin antibody. Hepsin expression was correlated with clinical-histopathological variables by usi

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XU, Xiwei, Tim Heath, Qing Xia, and Youtian Zhang. "DISASTER PREVENTION AND MITIGATION STRATEGIES FOR ARCHITECTURE HERITAGE CONCENTRATED AREAS IN CHINA." International Journal of Architectural Research: ArchNet-IJAR 9, no. 1 (2015): 108. http://dx.doi.org/10.26687/archnet-ijar.v9i1.525.

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This paper draws upon preliminary research into the insufficiencies of the status quo of the disaster prevention and mitigation in architecture heritage areas in China. It summarizes how the common hazards, which are various threats to the survival and development of the historical architectural heritage, such as fire, geological disasters and meteorological disasters occurs and their characteristics, and also analyses their impact on heritage. The paper also focuses on the disaster-prone parts of architecture heritage, exploring the proposals for evaluations of disaster-risk-factors, and the

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Mamedov, K. A., F. G. Seyfiyev, N. S. Gamidova, R. K. Gazieva, and G. B. Ibragimova. "Development of bitumen-polymer mastics for corrosion protection of pipelines of industrial transport system." Azerbaijan Oil Industry, no. 05 (May 15, 2025): 18–21. https://doi.org/10.37474/0365-8554/2025-05-18-21.

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It is known that long-term operation of oilfield equipment and hydraulic structures often leads to increased corrosion damage to underground and above-ground equipment, which is fraught with accidents, fire hazards, and uncontrolled oil spills. In order to improve the quality of anti-corrosion protection and increase the trouble-free service life of pipelines of the in-field transport system and hydraulic equipment, a bitumen-polymer mastic based on a non-scarce feedstock was developed and tested. Solvents (toluene, solvent, white spirit), 70/30 bitumen, liquid glass, petroleum polymer resins

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de Lusignan, Simon, F. D. Richard Hobbs, Harshana Liyanage, et al. "Long term follow up of direct oral anticoagulants and warfarin therapy on stroke, with all-cause mortality as a competing risk, in people with atrial fibrillation: Sentinel network database study." PLOS ONE 17, no. 9 (2022): e0265998. http://dx.doi.org/10.1371/journal.pone.0265998.

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Background We investigated differences in risk of stroke, with all-cause mortality as a competing risk, in people newly diagnosed with atrial fibrillation (AF) who were commenced on either direct oral anticoagulants (DOACs) or warfarin treatment. Methods and results We conducted a retrospective cohort study of the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) database (a network of 500 English general practices). We compared long term exposure to DOAC (n = 5,168) and warfarin (n = 7,451) in new cases of AF not previously treated with oral anticoagu

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Taniuchi, Keisuke, Makoto Ueno, Tomoyuki Yokose, et al. "Upregulation of PODXL and ITGB1 in pancreatic cancer tissues preoperatively obtained by EUS-FNAB correlates with unfavorable prognosis of postoperative pancreatic cancer patients." PLOS ONE 17, no. 3 (2022): e0265172. http://dx.doi.org/10.1371/journal.pone.0265172.

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The upregulation of PODXL and ITGB1 in surgically resected pancreatic cancer tissues is correlated with an unfavorable postoperative prognosis. The aim of this study was to investigate whether PODXL and ITGB1 are useful preoperative markers for the prognosis of postoperative pancreatic cancer patients in comparison with the TNM staging system. Immunohistochemistry was performed using anti-PODXL and anti-ITGB1 antibodies on 24 pancreatic cancer tissue samples preoperatively obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cox proportional hazards regression analysis was p

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Chen, Yen-Cheng, Liang-Tsai Yeh, Shun-Fa Yang, Ming-Chih Chou, Jing-Yang Huang, and Chao-Bin Yeh. "Risk of Thromboembolic Events and Major Adverse Cardiovascular Events Following Antivascular Endothelial Growth Factor Therapy in Patients with Colorectal Cancer." Cancers 15, no. 1 (2022): 9. http://dx.doi.org/10.3390/cancers15010009.

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Antivascular endothelial growth factor (anti-VEGF) therapy has been a standard treatment for patients with metastatic colorectal cancer. However, the risk of thromboembolic events and cardiovascular events associated with this therapy remains controversial. We assessed whether anti-VEGF therapy increases the risk of thromboembolic events or major adverse cardiovascular events (MACEs) in patients with colorectal cancer based on real-world evidence. This retrospective cohort study was designed using linked 2009–2016 nationwide databases, including the Taiwan Cancer Registry, the National Health

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Ali, Fahim, Syed Imran Ahmad Shah, Ramiz Shafqat, Muhammad Akhtar Abbas, and Mazhar Shah. "Assessing the Effectiveness of Punjab Traffic and Motorway Police's Anti-Smoke Campaign on Reducing Smog Levels in Punjab (Pakistan)." Journal of Asian Development Studies 13, no. 3 (2024): 1618–26. http://dx.doi.org/10.62345/jads.2024.13.3.130.

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Smog represents a critical environmental hazard contributing to severe health problems. Punjab faces significant environmental challenges, including resource scarcity, pollution, and climate change. This study assessed the effectiveness of anti-smog enforcement measures targeting motorists in Punjab. Time series data were collected from reputable sources, including the World Bank, Punjab Environmental Protection Agency, and Pakistan Bureau of Statistics. The data were analyzed using descriptive statistics and t-test methodology. Results indicated that air quality in most major cities of Punjab

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Su, Chien-Hao, Chung-Yu Chen, Chien-Ting Liu, Yi-Hsin Yang, and Pao-Chu Wu. "Hepatitis and Hepatitis B Virus Reactivation in Everolimus-Treated Solid Tumor Patients: A Focus on HBV-Endemic Areas." Cancers 16, no. 23 (2024): 3997. http://dx.doi.org/10.3390/cancers16233997.

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Background: Everolimus is approved for treating breast, renal, and pancreatic neuroendocrine cancers but carries the risk of hepatitis B virus (HBV) reactivation (HBVr) and hepatitis. However, data on HBVr in everolimus-treated patients are limited. This study evaluates the risk of hepatitis and HBVr in cancer patients with current or past HBV infection. Methods: This retrospective study analyzed patients prescribed everolimus between 1 January 2011 and 31 May 2022, using a private healthcare system database in Taiwan. Patients with HBsAg positivity or HBsAg negativity and anti-HBs or anti-HBc

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Kwak, Se Hyun, Dawoon Jeong, Jeongha Mok, et al. "Association between diabetes mellitus and cause of death in patients with tuberculosis: A Korean nationwide cohort study." PLOS ONE 18, no. 12 (2023): e0295556. http://dx.doi.org/10.1371/journal.pone.0295556.

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Despite its significant impact on mortality, tuberculosis (TB)-diabetes mellitus (DM) co-prevalence has not been well-elucidated for the cause of death. We investigated the impact of DM on TB-related and non-TB-related deaths in patients with TB. This retrospective nationwide cohort study included patients diagnosed with TB between 2011 and 2017 in South Korea. We performed Fine and Gray regression model analyses to assess the mortality risk of DM classified by cause of death. Of 239,848 patients, 62,435 (26.0%) had DM, and 20,203 died during anti-TB treatment. Of all deaths, 47.9% (9,668) wer

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Mukhopadhyay, Satabhisa, Tathagata Dasgupta, Nicolas M. Orsi, Michele Cummings, and Angelene Berwick. "Automated, IHC/FISH-free, H&E histopathology image-based HER2 amplification, tumor infiltrating lymphocyte (TIL) and tumor heterogeneity profiling in breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 593. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.593.

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593 Background: Digital pathology has fostered the development of automated diagnostic solutions. However, current technologies in breast cancer remain unable to determine HER2 amplification status, which is established by immunohistochemistry (IHC) and/or fluorescent in situ hybridization (FISH). These ancillary tests carry a significant cost, prolong diagnostic time and fail to capture HER2 tumor heterogeneity and tumor infiltrating lymphocyte (TIL) burden, both of which determine the effectiveness anti-HER2 targeted therapy. Methods: This study describes the real-life clinical context devel

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Eichinger, Sabine, Paul A. Kyrle, Michael Kammer, Lisbeth Eischer, and Christoph Binder. "Naturally Occurring Autoantibodies to Oxidation-Specific Epitopes in Patients with Venous Thromboembolism." Blood 124, no. 21 (2014): 2861. http://dx.doi.org/10.1182/blood.v124.21.2861.2861.

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Abstract Background: Naturally occurring IgM autoantibodies (NAb) recognize oxidation-specific epitopes which are altered self structures on apoptotic cells, oxidized LDL, or vessel wall proteins. Oxidation-specific epitopes are proinflammatory antigens and potential markers for chronic inflammatory conditions. The risk of venous thromboembolism (VTE) is associated with (pro)inflammatory states such as dyslipoproteinemia, obesity or cancer. We hypothesize that natural antibodies may target epitopes which are also involved in the pathogenesis of VTE. In pursuing a “proof of concept”, we studied

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Choudhary, S. K. "(A20) Injury Pattern and Disaster Plan for Landmines and Improvised Explosive Device Blast." Prehospital and Disaster Medicine 26, S1 (2011): s6. http://dx.doi.org/10.1017/s1049023x11000331.

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Landmines and improvised explosive device (IED) explosions induce bodily injuries through the primary, secondary, tertiary, and quaternary mechanisms of blast among civilians, mostly children which results in a complicated, multidimensional injury pattern. If > 80 percent of countries can ensure the security of their borders without using anti-personnel mines, surely India can too. A change in mindset and a change in defense doctrine are needed, as well as an UN-backed world body campaigning against the use of landmines to urge the Indian government to sign a global treaty to ban the weapon

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Westerlind, H., A. Kastbom, J. Rönnelid, et al. "POS0515 THE ASSOCIATION BETWEEN AUTOANTIBODIES AND RISK FOR VENOUS THROMBOEMBOLIC EVENTS AMONG PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 514–15. http://dx.doi.org/10.1136/annrheumdis-2022-eular.983.

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BackgroundPatients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease, including venous thromboembolic events (VTE)1. The reason behind the increased VTE risk is incompletely understood, but inherent features of RA, such as RA specific autoantibodies, could potentially play a role. For example, studies have linked occurrence and levels of rheumatoid factor (RF) in the general population to increased VTE risk2. We and others have demonstrated an association between ACPA and risk of later ischemic cardiovascular events3. There are also potential mechanistic links; c

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Shin, A., E. H. Park, Y. J. Ha, Y. J. Lee, Y. W. Song, and E. H. Kang. "THU0180 RISK MODIFICATION OF TUBERCULOSIS INFECTION BY CHEMOPROPHYLAXIS AMONG PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING TNF INHIBITORS: A NATION-WIDE COHORT STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 307–8. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2072.

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Background:Based on the benefit of chemoprophylaxis among patients receiving biologics [1], Health Insurance Review and Assessment (HIRA) service of Korea requires patients to undergo latent tuberculosis (LT) screening before initiation of any biologics and to receive chemoprophylaxis for positive LT.Objectives:To assess the effect of chemoprophylaxis on tuberculosis infection (TI) risk among patients with rheumatoid arthritis (RA) receiving biologics in KoreaMethods:Using 2002-2016 Korea National Health Insurance database, we conducted a cohort study on RA patients initiating biologic drugs (

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Knowlton, Kirk U., Lianne K. Siegel, Christina E. Barkauskas, et al. "Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials." PLOS Medicine 22, no. 7 (2025): e1004616. https://doi.org/10.1371/journal.pmed.1004616.

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Background Anti-SARS-CoV-2 monoclonal antibodies (mAb) reduce the risk of hospitalization in outpatients with mild-to-moderate COVID-19. However, the efficacy of treatment with mAbs and other passive immunotherapies in patients hospitalized with severe COVID-19 is not clear. The objective of this study was to assess the clinical effect of passive immunotherapy and its heterogeneity according to baseline endogenous neutralizing antibody status and SARS-CoV-2 antigen level, in adults hospitalized with SARS-CoV-2 infection and severe COVID-19. Methods and findings We carried out a two-stage indiv

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Bellan, Mattia, Lorenza Scotti, Daniela Ferrante, et al. "Risk of Severe Infection among Rheumatoid Arthritis Patients on Biological DMARDs: A Population-Based Cohort Study." Journal of Clinical Medicine 11, no. 11 (2022): 2955. http://dx.doi.org/10.3390/jcm11112955.

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Biological disease-modifying anti-rheumatic drugs (bDMARDs) are widely used for the management of rheumatoid arthritis, although their benefits are counterweight by an increased risk of infections. In the present study, we used administrative data to compare the risk of severe infections among different classes of bDMARDs. A retrospective cohort study was conducted using Administrative Health Databases of the Piedmont Region, Italy. Relevant data were obtained from: (1) the inhabitants registry, (2) hospital discharge records, and (3) the co-payment exemption registry and (4) drug claims regis

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Baginski, Thomas A., and Robert N. Dean. "The Reactive Bridge: A Novel Solid-State Low Energy Initiator." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2012, DPC (2012): 000586–614. http://dx.doi.org/10.4071/2012dpc-ta31.

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Within a broad variety of commercial (i.e. automotive airbags, mining) and government ordnance systems there exists an interface which utilizes electrical energy to initiate an exothermic reaction (i.e. combustion, deflagration, detonation). The structure that performs this function is commonly referred to as an Electro-explosive device (EED). The basic EED design is susceptible to initiation failures due to mechanical hazards such vibration and shock. This paper discusses the fabrication and characterization of a micro-machined EED (the Reactive Bridge) which is mechanically robust, extremely

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Nevskaya, T., Y. Jiang, M. Wang, et al. "FRI0258 CUMULATIVE INCIDENCE, SURVIVAL AND PREDICTORS OF PULMONARY HYPERTENSION IN SYSTEMIC SCLEROSIS SUBSETS: PAH IS NOT INCREASED IN LIMITED VS DIFFUSE PATIENTS BY ADJUSTED COMPETING RISK ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 713. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3847.

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Background:Pulmonary hypertension (PH) is a life-threatening complication of systemic sclerosis (SSc), thought to be more commonly found in limited cutaneous (lcSSc) compared to diffuse (dcSSc) subset. Since lcSSc has a better prognosis, it is unclear whether a higher occurrence of PH in lcSSc reflects survival bias.Objectives:To compare the cumulative PH incidence in disease subsets, after accounting for death as a competing event, in a large multi-center SSc cohort.Methods:Cumulative incidence of PH was studied in 1431 Canadian Scleroderma Research Group (CSRG) database patients (57% lcSSc;

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Yadav, Brijesh, Afzaal Nadeem Mohammed, Brittney Graham, Amit Bhattacharya, and Jagjit Singh Yadav. "Chronic Heat Exposure Modulates Innate and Adaptive Immune Responses in Firefighters." Environments 11, no. 6 (2024): 131. http://dx.doi.org/10.3390/environments11060131.

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Global fire activities, which are getting worse due to climate change, cause both environmental and human health hazards. Firefighters, being the first responders, are frequently exposed to heat which may impact their immune system and overall health. However, the nature of the impact of chronic heat exposure on immune function has not been studied in-depth in firefighters. In this study, 22 firefighters exposed to “heavy-smoke fires (structural fires)”, categorized as the “high-exposure group” (>0.15 structural fires/week) and “low-exposure group” (<0.15 structural fires/week), were sam

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Lukka, Himu, Stephanie L. Pugh, William U. Shipley, et al. "Long-term results of radiation with or without anti-androgens (AAT) in patients receiving salvage prostate bed radiation therapy (sRT) post prostatectomy." Journal of Clinical Oncology 42, no. 4_suppl (2024): 320. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.320.

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320 Background: sRT is used in men with prostate cancer (PC) recurrence following radical prostatectomy (RP) signaled by a persistent or delayed elevation in PSA. It was previously reported that the use of AAT with RT improved cancer control and overall survival (OS). Long-term follow-up (FU) results are presented here. Methods: From 1998to 2003, 760 eligible post-RP patients with Stage pT3N0 or with pT2N0 and positive margins and PSA from 0.2 to 4.0 ng/mL were randomly assigned on a double-blinded, placebo-controlled trial of RT + placebo vs. RT + anti-androgen therapy (AAT) (24 months of bic

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Raychaudhuri, Sreejata, Marcia L. Stefanick, Kerryn Reding, et al. "The relationship between cardiometabolic abnormalities and mortality among women with and without cancer in the Women’s Health Initiative (WHI)." Journal of Clinical Oncology 42, no. 16_suppl (2024): e24007-e24007. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e24007.

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e24007 Background: Prior studies of women with obesity-associated cancers in the Women’s Health Initiative (WHI) showed higher overall and mortality due to cardiovascular disease (CVD) for women with a higher number of cardiometabolic risk factors at baseline. It is unclear if this risk differs from women without cancer. In order to determine if this relationship differs among both groups, we compared the association between cardiometabolic risk factors and mortality among women in the WHI with and without cancer. Methods: Women with one of five early-stage obesity-associated cancers (breast,

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Farge, Dominique, Myriam Labopin, Alan Tyndall, et al. "Autologous Hematopoietic Stem Cell Transplantation (HSCT) for Autoimmune Diseases: 10 Years Experience from the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Autoimmune Diseases." Blood 112, no. 11 (2008): 164. http://dx.doi.org/10.1182/blood.v112.11.164.164.

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Abstract Introduction Since 1996 a joint collaborative effort from the European Group for Blood and Marrow Transplantation (EBMT) and League against Rheumatism (EULAR) collected cases of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) for patients (pts) with severe autoimmune diseases (AD). This retrospective observational study was designed to assess patients outcome and analyse the determinants of treatment responses after AHSCT. Methods All consecutive AD pts treated by AHSCT from 1996 to 2007 according to the EBMT-EULAR consensus statement with ethics committee approved protocol

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Alberti, S., P. Querzoli, M. Pedriali, et al. "Axillary lymph node nanometastases are prognostic factors for metastatic relapse in breast cancer patients." Journal of Clinical Oncology 24, no. 18_suppl (2006): 610. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.610.

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610 Background: Early breast cancer presents with a remarkable and largely unaccounted for heterogeneity of outcomes. Undetected, microscopic lymph node tumor deposits may account for a significant fraction of this prognostic diversity. Thus, we systematically evaluated the presence of lymph node tumor cell deposits <0.2 mm in diameter [pN0(i+), nanometastases], and analysed their prognostic impact. Methods: Seven hundred and two single institution, consecutive patients with 8 years of median follow-up were studied. To maximize the chances of detecting micro and nanometastases, whole-axilla

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Chen, Zhe, Xinping Tian, Jingge Qu, Jing Chen, Yunjiao Yang, and Jing Li. "Development and internal validation of a model to predict long-term survival of ANCA associated vasculitis." Rheumatology and Immunology Research 4, no. 1 (2023): 30–39. http://dx.doi.org/10.2478/rir-2023-0005.

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Abstract Objectives Risk stratification and prognosis prediction are critical for appropriate management of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Herein, we aim to develop and internally validate a prediction model specifically for long-term survival of patients with AAV. Methods We thoroughly reviewed the medical charts of patients with AAV admitted to Peking Union Medical College Hospital from January 1999 to July 2019. The Least Absolute Shrinkage and Selection Operator method and the COX proportional hazard regression was used to develop the prediction mo

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Nishino, Shunsuke, Hisashi Yamamoto, Mika Kuno, et al. "Conditioning with Fludarabine, Myeloablative Doses of Busulfan, and Melphalan (Flu/Bu4/Mel) Achieves Comparable or Superior Outcomes to Conventional Myeloablative Conditioning in Allogeneic Bone Marrow and Peripheral Blood Stem Cell Transplantation." Blood 144, Supplement 1 (2024): 3508. https://doi.org/10.1182/blood-2024-205008.

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Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a crucial therapeutic approach for myeloid malignancies. To maximize the efficacy of allo-HSCT, optimizing conditioning regimens to maintain anti-leukemic effects while minimizing non-relapse mortality (NRM) is essential. We have established a novel regimen of 180mg/m2 fludarabine, myeloablative doses (12.8mg/kg) of busulfan, and 80mg/m2 melphalan (Flu/Bu4/Mel) for relapse/refractory acute myeloid leukemia (AML) in single cord blood transplantation (sCBT), demonstrating its high anti-tumor efficacy without increasing

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Kim, Byung-Su, Won Kim, Inho Kim, et al. "Patients with Hematologic Malignancies May Be at Higher Risk of Hepatitis B Reactivation in Spite of Lamivudine Prophylaxis." Blood 114, no. 22 (2009): 1389. http://dx.doi.org/10.1182/blood.v114.22.1389.1389.

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Abstract Abstract 1389 Poster Board I-411 Introduction: Although lamivudine (LMV) prophylaxis is recommended for chronic hepatitis B (HBV) patients undergoing cytotoxic chemotherapy for their malignant disease, viral reactivation sometimes occurs during or after LMV administration. Patients with solid tumors and hematologic malignancies may have different risk of HBV reactivation because hematologic malignancies require more intensive and immunosuppressive treatment. The aims of this study are to determine predictors of LMV prophylaxis failure and to evaluate the relative risk of failure in pa

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