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Dissertations / Theses on the topic 'Anti-hepatitis-B'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Oliveira, Laura Ferreira. "Persistência de anticorpos protetores após sete anos de imunização contra hepatite b em lactentes em Goiânia – GO." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5433.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-04-04T20:19:20Z No. of bitstreams: 2 Dissertação - Laura Ferreira Oliveira - 2015.pdf: 1240339 bytes, checksum: 93a5f81eb7e7be949c0fb3fbffedb6c9 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-05T11:08:20Z (GMT) No. of bitstreams: 2 Dissertação - Laura Ferreira Oliveira - 2015.pdf: 1240339 bytes, checksum: 93a5f81eb7e7be949c0fb3fbffedb6c9 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (

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Keilhammer, Stefan [Verfasser], and Wolfgang [Akademischer Betreuer] Jilg. "Der Einfluss von Zytokinen, Anti-HBs-spezifischen T-Zellen und Anti-HBs auf Hepatitis B produzierende Zellen: Beobachtungen an einem Zellkultursystem als Model der chronischen Hepatitis B / Stefan Keilhammer. Betreuer: Wolfgang Jilg." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1095233335/34.

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Keilhammer, Stefan Verfasser], and Wolfgang [Akademischer Betreuer] [Jilg. "Der Einfluss von Zytokinen, Anti-HBs-spezifischen T-Zellen und Anti-HBs auf Hepatitis B produzierende Zellen: Beobachtungen an einem Zellkultursystem als Model der chronischen Hepatitis B / Stefan Keilhammer. Betreuer: Wolfgang Jilg." Regensburg : Universitätsbibliothek Regensburg, 2016. http://nbn-resolving.de/urn:nbn:de:bvb:355-epub-332721.

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4

Borges, A. L. S. "Avaliação dos níveis de anti-HBs pós booster em crianças, após sete anos do esquema vacinal primário." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6488.

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Submitted by Jaqueline Silva (jtas29@gmail.com) on 2016-11-10T17:16:50Z No. of bitstreams: 2 Dissertação - Ana Letícia Soares Borges - 2016.pdf: 2871403 bytes, checksum: 8e6a9f0ded122635cdcd6fc18a864f18 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2016-11-10T17:17:02Z (GMT) No. of bitstreams: 2 Dissertação - Ana Letícia Soares Borges - 2016.pdf: 2871403 bytes, checksum: 8e6a9f0ded122635cdcd6fc18a864f18 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made a

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Fung, Tak-kwan James. "Development of anti-HBs in patients with chronic hepatitis B after liver transplantation using lamivudine prophylaxis the possible role of adoptive immunity transfer /." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31980934.

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6

Neto, Gaspar Lisboa. "Influência da infecção pregressa pelo vírus da hepatite B em portadores de hepatite C crônica: análise histológica." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-02072009-095040/.

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INTRODUÇÃO: Os vírus das hepatites B (VHB) e C (VHC) são os principais causadores de hepatopatia crônica em todo mundo. Ambos compartilham vias semelhantes de transmissão. Em pacientes portadores crônicos de VHC com sorologia compatível com infecção pregressa pelo VHB (anti-HBcAg[+] e HBsAg [-]), o VHB DNA residual tem sido detectado por técnicas de biologia molecular altamente sensíveis no soro, em células linfomononucleares de sangue periférico e em hepatócitos (como cccDNA), de forma que o anti-HBcAg tem sido associado a pior prognóstico, tanto histológico quanto terapêutico. OBJETIVOS: Ana

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7

Bitencourt, Hellen Tayaná Oliveira. "Pesquisa e caracterização da hepatite B oculta em doadores de sangue do estado do Amapá." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17155/tde-07062017-161019/.

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Introdução. A infecção causada pelo vírus da hepatite B (HBV) é um dos agravos de maior prevalência no mundial. Segundo a Organização Mundial da Saúde (OMS) existem mais de 350 milhões de portadores crônicos da doença. A infecção pelo HBV é rotineiramente identificada quando há a presença do HBsAg circulante. Entretanto, em alguns casos o HBV-DNA tem sido detectado em indivíduos HBsAg negativos, positivos ou negativos para anti-HBc e anti-HBs. Essa apresentação sorológica e molecular é denominada infecção oculta pelo HBV (OBI). Geralmente a concentração do HBV-DNA no soro será abaixo de 200 UI

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8

Faupel, Fabian Matthias [Verfasser]. "Die Bedeutung von Anti-präS2-Antikörpern in der Diagnostik des Hepatitis-B-Virus / Fabian Matthias Faupel." Gießen : Universitätsbibliothek, 2011. http://d-nb.info/1061195570/34.

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9

Alfaiate, Dulce. "Study of the interplay between hepatitis B and hepatitis delta viruses and evaluation of investigational anti-HDV immuno-modulators in superinfection cell culture models." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10123/document.

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La surinfection par HDV/ HBV est la forme la plus grave d'hépatite virale chronique et affecte entre 15-20 millions de patients au niveau mondial. HDV n'est pas susceptible aux traitements anti-HBV et le taux de réponse à l'IFNα est <25%. Malgré une progression plus rapide de la maladie hépatique, la majorité des patients présente une suppression de la réplication du HBV. Les détails des interactions entre HDV, HBV et le système immunitaire inné des cellules infectées restent inconnus. Les objectifs de ces travaux de thèse ont été: i) l'étude de l'infection par HDV et son interaction avec l

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10

Fung, Tak-kwan James, and 馮德焜. "Development of anti-HBs in patients with chronic hepatitis B after liver transplantation using lamivudine prophylaxis: the possible role of adoptive immunity transfer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31980934.

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11

Filgueira, Fabiana Ariston. "Estudo de títulos protetores para o vírus de hepatite B após esquema vacinal de três doses e \"booster\" em crianças com HIV." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24112008-103206/.

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INTRODUÇÃO: A hepatite B é uma enfermidade para a qual não existe tratamento curativo efetivo e que pode determinar graves conseqüências, como o desenvolvimento de cirrose e carcinoma hepático. Segundo dados da OMS, mais de dois bilhões de pessoas estão infectadas pelo vírus da hepatite B e esta doença é responsável por 500.000 a um milhão de óbitos por ano, em todo o mundo. Em pacientes com infecção pelo HIV, é freqüente a co-infecção pelo vírus da hepatite B, pelo fato de serem vírus que compartilham modos semelhantes de transmissão. Em vista dessa problemática, a adequada imunização dos pac

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12

Lara, Amanda Nazareth. "Avaliação de marcadores sorológicos de proteção e infecção pelo vírus da hepatite B em pessoas vivendo com HIV/Aids, vacinadas previamente para hepatite B." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-07082017-092803/.

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INTRODUÇÃO: A infecção pelo vírus da hepatite B (VHB) é responsável por grande parte das doenças hepáticas crônicas em todo o mundo. Em pessoas vivendo com HIV/Aids (PVHA) a infecção pelo VHB tem maior risco de evolução para cirrose e carcinoma hepatocelular. A vacina da hepatite B é importante na prevenção de doença potencialmente grave, particularmente em PVHA, já que ambos os vírus têm as mesmas vias de transmissão e a coinfecção tem uma alta morbidade. Indivíduos imunocompetentes têm uma boa resposta humoral após uma primeira série de vacina da hepatite B e não há recomendações de rotina p

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13

Storer, Fábio Luiz. "Soropositividade, cobertura e resposta vacinal para hepatite vital do tipo B em cirurgiões dentistas em Porto Velho, Rondônia, Brasil." Universidade de Taubaté, 2008. http://www.bdtd.unitau.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=467.

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Neste estudo, hipotetizou-se que existia alta incidência de cirurgiões dentistas com baixa cobertura vacinal para hepatite B e positividade para contato prévio ou corrente para a hepatite viral do tipo B. O presente estudo transversal avaliou a condição vacinal e perfil sorológico dos cirurgiões dentistas para hepatite viral do tipo B no município de Porto Velho/RO - Brasil. Foram analisadas pela técnica de ELISA oitenta amostras de sangue (soro) dos cirurgiões dentistas residentes no município de Porto Velho/RO, visando a detecção dos marcadores sorológicos do Vírus da hepatite B: HBsAg, anti

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14

Khawaja, Ghada. "Évaluation d’une nouvelle approche vaccinale basée sur l’électroporation in vivo d’ADN pour le traitement des hépatites B chroniques." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10045.

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Malgré l’existence d’un vaccin préventif efficace, l’infection chronique par le virus de l’hépatite B (HBV) demeure un problème majeur de santé publique. La persistance de l’infection par HBV étant clairement associée à des réponses immunitaires insuffisantes, l’immunothérapie par le vaccin à base d’ADN nu, visant à stimuler les réponses humorales et cellulaires, apparaît comme particulièrement pertinente pour la thérapie des hépatites B chroniques. Toutefois, l’efficacité thérapeutique d’une telle stratégie reste limitée chez l’homme, d’où la nécessité d’optimiser cette approche vaccinale pou

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DI, PAOLO DANIELE. "Studio pilota prospettico per testare l’efficacia dell’immunoprofilassi attiva mediante schedula di vaccinazione rinforzata e a lungo termine con vaccino ricombinante S in combinazione con lamivudina ed immunoglobuline anti-HBs (HBIg) come strategia di prevenzione della ricorrenza di infezione da virus dell’epatite B in pazienti sottoposti a trapianto di fegato per malattia HBV correlata." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/451.

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L’immunoprofilassi attiva dopo trapianto di fegato con il vaccino ricombinante HBsAg è una potenziale strategia di prevenzione della ricorrenza di infezione da HBV dopo trapianto di fegato per malattia HBV-correlata. Studi precedenti sull’impiego della vaccinazione standard hanno mostrato risultati controversi, mentre l’utilizzo del nuovo adiuvante 3-deacilatomonosforil- lipide-A (MPL) ha incrementato in modo molto significativo la percentuale di risposta in termini di produzione anticorpale anti-HBs. Obiettivo: lo scopo principale è stato quello di testare l’efficacia di una schedula di

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Souza, Camila Lucas de. "Custo do teste Anti-HBs pós-vacinação primária em relação ao manejo para hepatite B pós-exposição à material biológico entre trabalhadores da área da saúde." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8669.

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Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2018-07-09T12:16:28Z No. of bitstreams: 2 Dissertação - Camila Lucas de Souza - 2018.pdf: 2326676 bytes, checksum: 8ce05f9e4402bf801ab775da922be861 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-10T10:59:46Z (GMT) No. of bitstreams: 2 Dissertação - Camila Lucas de Souza - 2018.pdf: 2326676 bytes, checksum: 8ce05f9e4402bf801ab775da922be861 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br

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Lindström, Anna. "Resistance to antiviral drugs in HIV and HBV /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-239-X/.

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18

Stubbe, Muriel. "Lymphocytes T CD4 et réponses vaccinales: du processus de différenciation à la mémoire immunologique." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210593.

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Les lymphocytes T CD4 (LT CD4) jouent un rôle central dans la régulation des réponses immunitaires vis-à-vis des agents infectieux et des vaccins. Cependant, leur différenciation in vivo est encore mal comprise et les caractéristiques des LT CD4 capables de persister à long terme tout en assurant une réponse immunitaire protectrice sont mal définies. L’approfondissement de ces connaissances est indispensable pour le développement de nouveaux vaccins. <p>Pour approcher cette question, nous avons utilisé deux approches expérimentales. La première est un suivi de la différenciation des LT CD4 au

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Taş, Tekin Kaya Selçuk. "Salt anti Hepatit B Virus Core antikoru pozitif kan donörlerinde Hepatit B Virus DNA tespiti /." Isparta : SDÜ Tıp Fakültesi, 2009. http://tez.sdu.edu.tr/Tezler/TT00398.pdf.

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Lopes, Leticia Pimenta. "Monitoramento do anticorpo anti-HBs em indivíduos renais crônicos vacinados contra hepatite B de um município do interior paulista." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-29082011-145348/.

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A vacinação é o método mais importante, barato e eficaz que se tem para a prevenção da transmissão do vírus da hepatite B (VHB). A vacina é indicada para indivíduos renais crônicos devido ao risco acrescido para aquisição do VHB durante a hemodiálise e a transfusão de sangue ou derivados. É indicado que a vacina seja administrada o mais precocemente possível ao entrar no programa de diálise, enquanto os indivíduos são bons respondedores. Este estudo teve como objetivo avaliar o monitoramento do anticorpo anti-HBs vacinal contra a hepatite B em pacientes renais crônicos, que iniciaram hemodiáli

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Assis, Jaqueline Calça. "Prevalência de anti-HBc isolado em amostras do instituto Adolfo Lutz e hepatite B oculta após resposta vacinal em pacientes do ambulatório municipal de hepatites virais." Faculdade de Medicina de São José do Rio Preto, 2016. http://hdl.handle.net/tede/422.

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Submitted by Suzana Dias (suzana.dias@famerp.br) on 2018-10-19T20:56:33Z No. of bitstreams: 1 JaquelineCalçaAssis_dissert.pdf: 1656909 bytes, checksum: 0f9e5425c7d3ffa51b86c71d5b4b9687 (MD5)<br>Made available in DSpace on 2018-10-19T20:56:33Z (GMT). No. of bitstreams: 1 JaquelineCalçaAssis_dissert.pdf: 1656909 bytes, checksum: 0f9e5425c7d3ffa51b86c71d5b4b9687 (MD5) Previous issue date: 2016-11-07<br>The presence of anti-HBc alone can have several meanings: false positive, healing immune window, delayed immunity or occult hepatitis B virus infection (OBI). In clinical practice, it is importan

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Albuquerque, Ingrid de Campos. "HBsAg e Anti-HBs presentes simultaneamente em uma população especifica de portadores do vírus da Hepatite B." Universidade Federal do Maranhão, 2016. http://tedebc.ufma.br:8080/jspui/handle/tede/579.

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Made available in DSpace on 2016-08-17T17:39:02Z (GMT). No. of bitstreams: 1 Dissertacao-IngridCamposAlbuquerque.pdf: 2786506 bytes, checksum: d6bc418f7fa6e1b080b2dbffb2078ddf (MD5) Previous issue date: 2016-05-12<br>INTRODUCTION: The concomitant presence of HBsAg and anti-HBs in hepatitis B virus (HBV) infections mainly results from isolated mutations in the a-determinant, which causes changes HBsAg antigenicity. This in turn causes variants unsusceptible to the neutralizing action of anti-HBs, thus permitting immune escape. Therefore, this study had the aim of identifying subjects with t

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Fei, Guo-Zhong. "Chronic hepatitis B : immunological, virological and clinical aspects in the natural course and during the combined prednisolone and interferon-alpha-2b therapy /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3868-7/.

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Caldwell, Sarah. "The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration." Thesis, 2014. http://hdl.handle.net/10210/10202.

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M.Tech. (Homoeopathy)<br>According to the World Health Organisation (2008), an estimated two billion individuals globally, are infected with Hepatitis B (HBV). South Africa reported 864 notified new cases between 2001 and 2004 (Department Of Health, 2005), with an estimated 3-4 million chronic HBV infected black South Africans (Kew, 2008). Kwa-Zulu Natal and Free State were the most affected provinces; while 20-39 years was the most affected age group as of 2005 (Department Of Health, 2005). Workers in the health industry, intravenous drug users and children of women who have Hepatitis B are a

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Ivacik, Dejana. "Developing use for recombinant lentiviral vectors for delivery of anti-hepatitis B virus micro RNA mimics." Thesis, 2014. http://hdl.handle.net/10539/15445.

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Persistent infection with hepatitis B virus (HBV) is associated with an increased risk for development of serious life-threatening complications such as cirrhosis and hepatocellular carcinoma (HCC). This common malignancy is aggressive and has a very poor prognosis. Currently available HBV therapies have variable efficacy and do not diminish the risk for development of HCC associated with infection with the virus. Consequently the development of novel therapies aimed at providing effective treatment for chronic HBV infection remains a medical priority. The therapeutic potential of harnessing

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周世認. "Duck hepatitis B virus as a model system for screening Chinese herbs with anti-hepadnaviral effect." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/60376384759741543701.

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Shen, Chia-I., and 沈佳怡. "Mechanistic study of anti-hepatitis B virus and gluconeogenesis of Scutellariae radix in human hepatoma cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/85881416143091150940.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>98<br>The Chinese herbal medicine, Xiao-Chai-Hu-Tang, is a seven components prescription used for liver disease treatment. Our laboratory has found Scutellaria radix (1S), a major component of Xiao-Chai-Hu-Tang, is in possession of suppressing hepatitis B virus surface antigen (HBsAg) secretion in HepG2/A2 cells. In this thesis, human hepatoma cell lines 1.3ES2, HepG2/A2 and Hep3B/T2 were used to elucidate the mechanism of anti-HBV effect of Scutellaria radix including two of its components, Chrysin and Wogonin. In this study, it was found that 1S, Chrysin and Wog

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Jhuang, Hong-Jhih, and 莊弘志. "Mechanistic Study of Anti-hepatitis B Virus and Gluconeogenensis of Graptopetalum paraguayense in Human Hepatoma Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/30434953510457775419.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>102<br>Hepatitis B virus (HBV) infection has been documented to be associated with developing liver cirrhosis and hepatocellular carcinoma (HCC). Currently, the major strategy of treatment is to target viral polymerase/reverse-transcriptase activity. However, adverse side effects, drug resistance, and incomplete therapeutic effect of these anti-HBV drugs are reported. PGC-1α, a major metabolic regulator of gluconeogensis, is known to be strongly induced to coactivate HBV gene expression in the liver of fasting mice. In this study, we found that combination of 8-Br

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Crowther, Carol. "Recombinant Pegylated first and third generation adenovirus vectors for delivery of anti-Hepatitis B virus RNA interference effectors." Thesis, 2014.

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Hepatitis B virus (HBV) is hyperendemic to southern Africa and parts of Asia where it is a major cause of serious liver disease. Licensed antivirals for chronically infected individuals are only partially effective and approximately one million deaths occur annually as a result ofpersistent infection with the virus. Although RNA interference (RNAi) based gene silencingof HBV has been successfully demonstrated, difficulties with delivery of anti-HBV RNAieffectors remains an obstacle to their clinical use. Recombinant adenoviruses (Ads), amongst the most efficient hepatotropic gene vectors fol

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許順翁. "A Study of Anti-Tumor Effects on Seven Kinds of Tumor Cells and Anti-Hepatitis B Virus Activities of Nobiletin and Tangeretin." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/25583054531156790000.

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碩士<br>美和科技大學<br>生技科技系健康產業碩士班<br>102<br>Nobiletin and tangeretin are two pure compounds belonging to Polymethoxylated Flavones, PMF, and have anti-inflammatory, radical scavenging activity and hypocholesterol functions. The goal of this study is to explore their anti-tumor effects on 7 kinds of tumor cells (i.e., hepatoma, breast cancer, lung cancer, gastric cancer, colon cancer, brain cancer and leukemia). MTT assay data showed that nobiletin and tangeretin have no effects on gastric cancer cells (AGS), brain cancer cells (U87) or lung cancer cells (H2981); slight inhibition on breast cancer

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Huang, Rui-Ling, and 黃瑞齡. "STUDIES ON THE AUTI-HEPATITIS B VIRUS AND ANTI-TUMOR EFFECTS OF CHINESE DRUGS AND FOLK HERBS." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/95974895032665488665.

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Wu, Yi-Chieh, and 吳宜潔. "Mechanistic study of anti-human hepatitis B virus activity of Scutellaria radix & Wogonin in human hepatoma cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/63318464136137914502.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>97<br>Hepatitis B virus (HBV) infection causes acute and chronic hepatitis, and the affected patients have an increased risk of developing liver cirrhosis and hepatocellular carcinoma (HCC). Although a preventive vaccine for HBV is available, effective drugs to eradicate HBV in chronic carriers are still urgently needed.The Chinese herbal medicine Xiao-Chai-Hu-Tang consists of Bupleuri radix and Scutellaria radix (HD-1S) and is widely used for treatment of liver disease. In searching of compounds on suppression of hepatitis B surface antigen (HBsAg) production, ou

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Dreyer, Timothy James. "Talen-mediated homology directed insertion of anti-viral sequences to inhibit hepatitis B viral gene expression and replication." Thesis, 2015. http://hdl.handle.net/10539/18492.

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More than 350 million people are chronic hepatitis B virus (HBV) carriers. Viral covalently closed circular DNA (cccDNA) persists as a replication intermediate and can remain dormant. Current HBV therapeutics do not eradicate viral cccDNA reservoirs. Transcription activator-like effector nucleases (TALENs) target and cleave specific DNA sequences, and have shown promise as antiviral agents. Here we propose TALEN-mediated homology directed disruption and silencing of the cccDNA. The designer TALENs introduce double stranded breaks (DSBs) at the HBV cccDNA core and surface ORFs, which activate t

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ZHANG, CHUN-FAN, and 張春梵. "Screening methods for Chinese medicinal herbs with anti-hepadnavirus effects: duck hepatitis B virus DNA polymerase as an indicator." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/95566511086825440315.

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Huang, Yan-Xue, and 黃硯學. "Mechanistic study of Scutellaria radix action on anti-hepatitis B viral gene expression and gluconeogenesis in human hepatoma cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/36437973622222341075.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>Hepatitis B virus (HBV) infection has been documented to associate with developing liver cirrhosis and hepatocellular carcinoma. In previous study, we have identified Chinese herb Scutllariae radix (HD-1S) can suppress HBV gene expression and virus production in human hepatoma cells. The HBV suppressive effect of HD-1S is regulated mainly at the transcriptional level via core promoter by recruitment of cellular transcriptional factors and coactivator PPARγ coactivator-1α (PGC-1α) to play a role as anti-HBV agent. Comparison of the list of liver transcriptio

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Shie, Pei-Hsin, and 謝佩勳. "Studies on the components analysis, antioxidant, and anti-hepatitis B virus activities on Citrus limon Burm. and Citrus madurensis Lour." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/66604804948649989137.

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碩士<br>國立屏東科技大學<br>農園生產系所<br>98<br>Citrus, an evergreen tree in the family Rutaceae, is one of the most important world fruit crops and is consumed mostly as fresh produce or juice because of its nutritional value and special flavour. The aim of this study was to determine the content of components (hesperidin, diosmin, neohesperidin, 5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone, limettin, bergapten, nobiletin, tangeretin, and synephrine) in different harvest months, size of fruits, and parts of fruits from lemon (C. limon Burm. cv. Eureka) and mandarin (C. madurensis Lour.) by high performance li

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Chou, Yu-Chi, and 周祐吉. "Elucidation of transcriptional regulation on hepatitis B virus cccDNA and anti-viral effect of transforming growth factor-beta1 on HBV replication." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/31086204988499485215.

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博士<br>國立陽明大學<br>微生物及免疫學研究所<br>93<br>In the first part of this thesis, we have evaluated the transcriptional efficiency of covalently closed circular DNA by using a RT-PCR combined with restriction enzyme digestion method. Virus persistence in chronic hepatitis B patient is manifested by sustaining a pool of covalently closed circular DNA (cccDNA) in the nucleus of the infected hepatocytes that presumably serves as a template for HBV genes expression. We used a modified 1.3-fold HBV genome, with a BclI-genetic marker embedded in the 5’-end redundancy region, to examine the transcriptional activ

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Liu, Shu-Heng, and 劉書亨. "Anti-viral mechanism of natural constituents from Artemisia morrisonensis against hepatitis B virus and molecular phylogenetic analysis of related Artemisia plant species." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/52236643720874387440.

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碩士<br>中國醫藥大學<br>生態暨演化生物學研究所碩士班<br>101<br>Artemisia morrisonensis （AM）is an endemic alpine species of Artemisia in Taiwan and is proposed to have wide range of therapeutic effects on liver related disease. However, the active constituent of A. morrisonensis against hepatitis B virus (HBV) is still remained unknown. The aims of this study were attempted to elucidate the anti-viral mechanism of natural occurring constituents against HBV from A. morrisonensis and the molecular phylogenetic analysis of Artemisia related species was also be conducted. Initially, the extracts of AM-AQ, AM-EA1, AM-EA2

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LIANG, MING-ZONG, and 梁明宗. "Studies on the possibility of duck hepatitis B virus carrier as an in vivo system for screening the Chinese herbs with anti-hepadnavirus effect." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/33456369865936434782.

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Lin, Ching-Hsiang, and 林靖翔. "Studies on the chemical constituents from the leaves and twigs of Symplocos juiyenensis, structure modification to phenolic acids and their evaluation of anti-hepatitis B virus activity." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/8n7yyy.

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碩士<br>中國醫藥大學<br>生物科技學系碩士班<br>102<br>Symplocaceae consists of two genera and distributes in tropical and subtropical areas in Asia, Australia and America. Some species are used as traditional herbal medicines, for example, Symplocos caudate (SC) recorded in Pen ts’ao kang mu are being used for the treatment of arthritis and jaundice. Since their great structural biodiversity and versatile biological activities in antimicrobial, anti-HIV activities and antitumor applications, much attention has paid to these plants. Symplocos contains 28 species (9 endemic) according to 2 nd edition of Flora of

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Lin, Sheng-kai, and 林聖凱. "An association study on the genetic polymorphisms in IGF2, IGFBP3 and SRD5A2 and responsiveness to booster hepatitis B vaccination in residual anti-HBs-seronegative senior high school students." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/44600007153381764381.

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碩士<br>慈濟大學<br>原住民健康研究所<br>94<br>In Taiwan, the implement of universal hepatitis B (HB) vaccination program (UHBVP) had successfully reduced the rates of HBsAg-seropositivity and hepatocellular carcinoma incidence in children. However, approximately 5-10% of vaccinated-children were low- or non-response to hepatitis B vaccine. Several researches had shown that there were gender and ethnic variations in the response to hepatitis B vaccine. The non-response rate was higher in male children than in female children and the efficacy of HB vaccination was lower in indigenous children than in Hans chi

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Chang, Chia-Hsin, and 張加欣. "Selective Synthesis of Helioxanthin Derivatives with Anti-Hepatitis B Activities via Wittig-Knoevenagel Cyclization and Their Structure-Activity Relationship; Preliminary Studies on the Synthesis of Nitrogen Containing Acene Derivatives via Friedlander Co." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/aa699d.

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碩士<br>國立臺灣科技大學<br>工程技術研究所<br>99<br>Part One In previous studies, lignan helioxanthin (He-145) isolated from Taiwania cryptomerioides exhibits remarkable anti-HBV activity. During structure-activity mapping, it was discovered that one He-145 derivative with lactam structure exhibits the highest antiviral activity. In the first part of this dissertation, we developed a selective synthetic scheme for this class of compounds. In twenty compounds we synthesized, six exhibit significant anti-HBV activities. Their structure-activity relationship was also discussed. Part Two Nitrogen containing he

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"Anti-HBV effects of three phyllanthus species and purification of its active component." 2004. http://library.cuhk.edu.hk/record=b5896188.

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Lam Kit.<br>Thesis submitted in: July 2002.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (leaves 141-153).<br>Abstracts in English and Chinese.<br>Acknowledgment --- p.I<br>Table of Content --- p.II<br>List of Tables --- p.VII<br>List of Figures --- p.IX<br>Abbreviations --- p.XIV<br>Abstract --- p.XVI<br>論文摘要 --- p.XIX<br>Chapter CHAPTER 1 --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Hepatitis B --- p.1<br>Chapter 1.1.1 --- Brief Introduction of HBV --- p.1<br>Chapter 1.1.2 --- History of Hepatitis B Virus --- p.2<br>Chapter 1.1.

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Smit, Duodane. "Helper-dependent adenoviral vectors expressing anti-HBV pri-miR sequences from the liver-specific PEPCK promoter." Thesis, 2017. http://hdl.handle.net/10539/23115.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2017<br>Hepatitis B is a global health problem that kills about 600 000 people annually. It is an infectious disease caused by the Hepatitis B Virus (HBV), which infects the liver and leads to liver inflammation and secondary complications such as cirrhosis and Hepatocellular Carcinoma (HCC). The available therapies are only partially effective and are associated with adverse side effects a

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Mlambo, Tafadzwa. "Expression of anti-HBV primary micro-RNA shuttles using an inducible promoter system." Thesis, 2014.

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Hepatitis B virus (HBV) infection is an important global health concern and chronic carriers of the virus are at high risk of developing hepatocellular carcinoma (HCC) and cirrhosis. Current therapies are only partially effective, which emphasises the need for improved treatment strategies. Harnessing the RNA interference (RNAi) pathway as a treatment strategy against HBV has shown great promise. However, there are obstacles that need to be overcome before RNAi-based treatment of HBV infection is realised. These include problems of liver tissue targeting and dose regulation. This study investi

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