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Journal articles on the topic 'Anti-hyperglycemic activity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Bafail, Rawan S. M., and Waad A. Samman. "Anti-parkinsonian, anti-inflammatory, anti-microbial, analgesic, anti-hyperglycemic and anticancer activities of poly-fused ring pyrimidine derivatives." Tropical Journal of Pharmaceutical Research 23, no. 1 (2024): 67–75. http://dx.doi.org/10.4314/tjpr.v23i1.9.

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Purpose: To investigate the anti-inflammatory, anti-cancer, anti-parkinsonian, anti-microbial, analgesic, and anti-hyperglycemic properties of a variety of poly-fused pyrimidine derivatives. Methods: A novel series of fused pyrimidine derivatives 1-6 were synthesized by reacting amino pyrazole derivatives with active methylene derivatives to give the corresponding compounds 1-6. Anti-parkinsonian activity was investigated with benzotropene as a reference drug, anti-inflammatory effect in mice was evaluated using carrageenan in paw edema with indomethacin as reference drug, anti-microbial

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2

Choudhary, Shailesh Kumar, Gagan Chhabra, Dipali Sharma, Aruna Vashishta, Sujata Ohri, and Aparna Dixit. "Comprehensive Evaluation of Anti-hyperglycemic Activity of FractionatedMomordica charantiaSeed Extract in Alloxan-Induced Diabetic Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/293650.

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The present study evaluates anti-hyperglycemic activity of fractionatedMomordica charantia(bitter gourd) seed extracts. Fasting blood glucose levels were evaluated before and after administration of different fractions of the seed extract. Among the three fractions tested, fraction Mc-3 (15 mg/kg b.wt.) showed the maximum anti-hyperglycemic activity and reduced blood glucose levels in experimental diabetic rats significantly. The activities of the key regulatory enzymes of glucose metabolism (hexokinase, pyruvate kinase, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase) were determ

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3

Bellamakondi, Pavan Kumar, Ashok Godavarthi, and Mohammed Ibrahim. "Anti-hyperglycemic activity of Caralluma umbellata Haw." BioImpacts 4, no. 3 (2017): 113–16. http://dx.doi.org/10.15171/bi.2014.003.

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4

Md., Lokman Hossain, Monjur-Al-Hossain A.S.M., Saha Subarna, and Kumar Sadhu Samir. "Assessment of Biological Activity on Cirsium arvense L." Algerian Journal of Natural Products 5, no. 1 (2017): 417–26. https://doi.org/10.5281/zenodo.824566.

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This study was aimed at evaluating antibacterial, cytotoxic, anthelmintic and anti-hyperglycemic activity of aerial part of <em>Cirsium arvense</em>. Antibacterial activity was determined by disc diffusion method at the concentration of 200, 250 and 500 µg/disc. Cytotoxic and anthelmintic activity was carried out according to Meyer and Gade method with slight modification respectively. The anti-hyperglycemic activity was determined by the method followed by Djilani. The extract showed dose dependent antibacterial activity against the experimental bacterial strains except <em>Staphylococcus epi

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Priya, Bhanu, Manoj Gahlot, and Punam Joshi. "Screening of Anti-hyperglycemic Activity of Kigelia africana on Alloxan-Induced Diabetic Rats." Indian Journal of Applied Research 4, no. 6 (2011): 448–51. http://dx.doi.org/10.15373/2249555x/june2014/140.

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6

Zhang, Baoshun, Tingting Chen, Zhu Chen, et al. "Synthesis and anti-hyperglycemic activity of hesperidin derivatives." Bioorganic & Medicinal Chemistry Letters 22, no. 23 (2012): 7194–97. http://dx.doi.org/10.1016/j.bmcl.2012.09.049.

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7

Ruíz-Aguilar, Isay, Ofelia Gabriela Meza-Márquez, Guillermo Osorio-Revilla, Tzayhri Gallardo-Velázquez, and Oswaldo Arturo Ramos-Monroy. "Phytochemical Compounds, and Antioxidant, Anti-Hyperglycemic, and Anti-Inflammatory Activity of Microencapsulated Garambullo (Myrtillocactus geometrizans) Extract During In Vitro Digestion and Storage." Processes 12, no. 11 (2024): 2526. http://dx.doi.org/10.3390/pr12112526.

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Garambullo fruit (Myrtillocactus geometrizans) is a rich source of phytochemical compounds that exhibit antioxidant, anti-hyperglycemic, and anti-inflammatory activities, helping to prevent diseases associated with oxidative stress. The objective of this study was to evaluate phenolic compound (PC), betalain (BL), betaxanthin (BX), and betacyanin (BC) contents, and in vitro biological activities (antioxidant, anti-hyperglycemic, and anti-inflammatory) in microencapsulated garambullo extract during in vitro gastrointestinal digestion and storage. Microencapsulation was performed using spray dry

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8

Bunyakitcharoen, Athit, Weerakit Taychaworaditsakul, Seewaboon Sireeratawong, and Sunee Chansakaow. "Anti-Hyperglycemic Effects of Thai Herbal Medicines." Plants 13, no. 20 (2024): 2862. http://dx.doi.org/10.3390/plants13202862.

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This study aims to investigate selected medicinal plants’ anti-oxidative and antihyperglycemic activities to develop an effective remedy for lowering blood glucose levels and/or reducing diabetes complications. Thai medicinal plants, reported to have blood sugar-lowering effects, were selected for the study: Coccinia grandis, Gymnema inodorum, Gynostemma pentaphyllum, Hibiscus sabdariffa, Momordica charantia, Morus alba, and Zingiber officinale. Each species was extracted by Soxhlet’s extraction using ethanol as solvent. The ethanolic crude extract of each species was then evaluated for its ph

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9

Minh Trang, Vu, Bui Van Trung, Phan Minh Giang, Do Thi Viet Huong, and Nguyen Tien Son. "Antiglycemic Activity of Vietnamese Scutellaria barbata Extract in Streptozotocin-Induced Diabetic Mice." Journal of Food Biochemistry 2024 (May 18, 2024): 1–8. http://dx.doi.org/10.1155/2024/8039043.

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Scutellariabarbata D. Don (S. barbata), a medicinal herb commonly used in traditional Chinese and Korean medicine, consists of bioactive neoclerodanes and flavonoids. However, its anti-hyperglycemic activity has not been reported. In this work, we used bioassay-guided fractionation to find effective anti-hyperglycemic fractions of S. barbata. The chemical components of these fractions were also determined structurally; they are scutellarin (1), luteolin (2), naringenin (3), tricin (4), baicalein (5), baicalin (6), apigenin (7), and wogonin (8). The most potent fraction SB6 consisting of flavon

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10

Prateek, Pandey1* Shradha Pandey2 Alok Mukerjee1. "ATTENUATION OF HYPERGLYCEMIA IN STREPTOZOTOCIN-INDUCED DIABETIC RATS BY BAUHINIA VARIEGATA FLOWER EXTRACT." Journal of Pharma Research 8, no. 11 (2019): 676–83. https://doi.org/10.5281/zenodo.3595210.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>o evaluate the anti-hyperglycemic activity of ethanolic extract of Bauhinia variegata flower (BVE) using streptozotocin (STZ) model and anti-oxidant activity of BVE evaluated by in-vitro methods. Ethanolic extract of Bauhinia variegata flower (BVE) 200 and 400 mg/kg body weight was administered orally according to different groups of animals once a daily for 21 days. Blood glucose levels were estimated at 0, 7<sup>th</sup>, 14<sup>th</sup> and 21<sup>st</sup> day by glucometer (one-touch) and on 21<sup>st</sup> day biochemical p

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11

Estella, Odoh Uchenna, Owoh Chioma, Obi Patrick Ebele, Chukwuma Micheal Onyegbulam, Agubata Chuka William, and Odoh C. Longinus. "Pharmacognostic Profile and Anti-Hyperglycemic Activity of Jatropha Tanjorensis Linn (Euphorbiaceae) Leaf on Alloxan-Induced Hyperglycemic Rats." Journal of Advances in Medical and Pharmaceutical Sciences 25, no. 5 (2023): 30–42. http://dx.doi.org/10.9734/jamps/2023/v25i5619.

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Background: Jatropha tanjorensis has been used traditionally for the treatment of a variety of diseases, these include; renal problem, cardiovascular disease, hypertension, inflammation and in moderate depression. The pharmacognostic standardization of it’s can be used in the development of it’s monograph. Diabetes mellitus is disease that is responsible for millions of death yearly. Over the years, efforts have been made in the discovery of new bioactive compounds with Antidiabetic activity Objective: The objective of the study was to establish the pharmacognostic profile and anti-hyper

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12

Nguyen, Ngoc Hong, Quang Thang Pham, Thi Ngoc Han Luong, Hoang Khai Le, and Van Giau Vo. "Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati)." Biomolecules 10, no. 2 (2020): 201. http://dx.doi.org/10.3390/biom10020201.

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Adenosma bracteosum Bonati. (A. bracteosum) has been used in traditional and modern medicine in Vietnam for curing hepatitis. In this study, ethanol and aqueous extracts of A. bracteosum were evaluated for their α-glucosidase inhibitory activities and anti-hyperglycemic effects on glucose loaded hyperglycemic and streptozotocin (STZ) induced diabetic mice. The α-glucosidase inhibition of the extracts was evaluated by colorimetric assays, and the anti-diabetic activity was tested on a STZ-induced diabetic mice model. The ethanol and aqueous extracts showed a significant α-glucosidase inhibitory

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13

Silva Comilo, Geovanni, Karen Keli Barbosa Abrantes, Karina Miyuki Retamiro, et al. "Pressurized Liquid Extraction of Bioactive Compounds from Seeds and Sprouts Trigonella foenum-graecum L. (Fenugreek): Enhanced Antioxidant and Anti-Hyperglycemic Activities." Foods 14, no. 12 (2025): 2021. https://doi.org/10.3390/foods14122021.

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The present study examined the impact of germination using Aloe vera as an elicitor on the phytochemical composition, antioxidant capacity, and in vitro anti-hyperglycemic and antitumoral activity of fenugreek seed extracts germinated by pressurized n-propane. The lipid composition, free fatty acids, antioxidant activity, and phenolic content, as well as the contents of α-tocopherol, β-carotene, and minor compounds, have been determined for the extracts. The in vitro anti-hyperglycemic and anticancer activities were also evaluated in cervical cancer (HeLa) and colon cancer (SiHa) cell lines. A

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14

Escandón-Rivera, Sonia, Araceli Pérez-Vásquez, Andrés Navarrete, et al. "Anti-Hyperglycemic Activity of Major Compounds from Calea ternifolia." Molecules 22, no. 2 (2017): 289. http://dx.doi.org/10.3390/molecules22020289.

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15

Mpiana, P. "Anti-Hyperglycemic Activity of Raphia gentiliana De Wild. (Arecaceae)." European Journal of Medicinal Plants 3, no. 2 (2013): 233–40. http://dx.doi.org/10.9734/ejmp/2013/2459.

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16

Korthikunta, Venkateswarlu, Jyotsana Pandey, Rohit Singh, et al. "In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives." Phytomedicine 22, no. 1 (2015): 66–70. http://dx.doi.org/10.1016/j.phymed.2014.09.007.

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17

Gao, Yuan, Yan-Fen Niu, Fei Wang, et al. "Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa." Natural Products and Bioprospecting 6, no. 5 (2016): 247–55. http://dx.doi.org/10.1007/s13659-016-0109-3.

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18

Win, Pyae Phyo, Thurein Lynn, Htin Lin Naing Soe, Kyaw Zwar Htoon, and Khin Ohnmar Kyaing. "The antihyperglycemic activity of leaves of Leptadenia reticulata Wight & Arn. (Goan- kha) on adrenaline-induced hyperglycemic rats." GSC Biological and Pharmaceutical Sciences 31, no. 02 (2025): 085–92. https://doi.org/10.30574/gscbps.2025.31.2.0170.

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Background: In Myanmar, the leaves of Leptadenia reticulata Wight & Arn. (locally known as Goan-kha) are traditionally used for their purported anti-hyperglycemic effects. However, scientific validation of these effects remains limited.Objective: To evaluate the anti-hyperglycemic activity of a 70% ethanolic extract of Leptadenia reticulata Wight & Arn. leaves in an adrenaline-induced hyperglycemia model in rats.Method: A laboratory-based experimental study was conducted using thirty Wistar rats (180–220 g), which were randomly assigned into five groups (n = 6 per group): a norma

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19

Sunarwidhi, Anggit Listyacahyani, Wahyu Rahmaniar, Eka Sunarwidhi Prasedya, et al. "In Vitro Anti-Oxidant, In Vivo Anti-Hyperglycemic, and Untargeted Metabolomics-Aided-In Silico Screening of Macroalgae Lipophilic Extracts for Anti-Diabetes Mellitus and Anti-COVID-19 Potential Metabolites." Metabolites 13, no. 12 (2023): 1177. http://dx.doi.org/10.3390/metabo13121177.

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COVID-19 patients with comorbid DM face more severe outcomes, indicating that hyperglycemic conditions exacerbate SARS-CoV-2 infection. Negative side effects from existing hyperglycemia treatments have urged the need for safer compounds. Therefore, sourcing potential compounds from marine resources becomes a new potential approach. Algal lipids are known to possess beneficial activities for human health. However, due to limitations in analyzing large amounts of potential anti-hyperglycemic and anti-COVID-19-related marine metabolites, there is an increasing need for new approaches to reduce ri

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20

Haroun, Michelyne. "In Silico Design, Synthesis and Evaluation of Novel Series of Benzothiazole- Based Pyrazolidinediones as Potent Hypoglycemic Agents." Medicinal Chemistry 16, no. 6 (2020): 812–25. http://dx.doi.org/10.2174/1573406416666191227113716.

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Background: The discovery of novel ligand binding domain (LBD) of peroxisome proliferator- activated receptor γ (PPARγ) has recently attracted attention to few research groups in order to develop more potent and safer antidiabetic agents. Objective: This study is focused on docking-based design and synthesis of novel compounds combining benzothiazole and pyrazolidinedione scaffold as potential antidiabetic agents. Methods: Several benzothiazole-pyrazolidinedione hybrids were synthesized and tested for their in vivo anti-hyperglycemic activity. Interactions profile of title compounds against PP

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21

Zod, Neha L., and Rahul G. Ingle. "Anti-hyperglycemic Activity of the Piper longum Dried Fruit Extract on the Experimental Animal Model." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 645–48. http://dx.doi.org/10.25258/ijpqa.15.2.14.

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Predominately, in the Indian tradition, the species Piper longum could play a significant role in the management of several severe disorders such as asthma, tuberculosis, rheumatism, and epilepsy. Mostly, the plant root would be responsible for treating insomnia, rheumatism, and epilepsy, as well as plant leaves for a prevailing stimulant for both the digestive and the respiratory systems. The alcoholic extract of P. longum fruits showed antiamoebic, anti-inflammatory, and immunomodulatory potential in experimental animals. In addition to these benefits, the current study concluded that the ex

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22

D., Sukumar, and Brahma Srinivasa Rao Desu. "ASSESSMENT OF ANTI - HYPERGLYCEMIC ACTIVITY OF A POLYHERBAL FORMULATION BS019." International Journal of Advanced Research 7, no. 12 (2019): 1076–80. http://dx.doi.org/10.21474/ijar01/10257.

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23

Gunjal, Ankush, Manisha Walunj, Hetal Aghera, Mukesh Nariya, and MandipR Goyal. "Hypoglycemic and anti-hyperglycemic activity of Triphalādi granules in mice." Ancient Science of Life 35, no. 4 (2016): 207. http://dx.doi.org/10.4103/0257-7941.188177.

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24

SHIROSAKI, Miyuki, Tomoyuki KOYAMA, and Kazunaga YAZAWA. "Anti-Hyperglycemic Activity of Kiwifruit Leaf (Actinidia deliciosa) in Mice." Bioscience, Biotechnology, and Biochemistry 72, no. 4 (2008): 1099–102. http://dx.doi.org/10.1271/bbb.70704.

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25

Anarado, C. J. O., C. E. Anarado, O. F. Obumselu, C. G. Iziga, I. L. Anarado, and E. H. Onyilogwu. "Phytochemical, in vitro Antimicrobial, Proximate, Anti-inflammatory, Antioxidant and Anti-hyperglycemic Activities of Root Extracts of Combretum platypterum (Welw)." Asian Journal of Applied Chemistry Research 14, no. 1 (2023): 35–43. http://dx.doi.org/10.9734/ajacr/2023/v14i1257.

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Aim: This work was to determine the phytochemical, proximate, in vitro antimicrobial, antioxidant, anti-inflammatory, and anti-hyperglycemic activities of root extracts of Combretum platypterum. Methods: Roots of C. platypterum were cold extracted with methanol, ethyl acetate, and n-hexane. The extracts were subjected to proximate, phytochemical analyses, antimicrobial, antioxidant, anti-inflammatory, and anti-hyperglycemic assays. Results: The result of proximate analysis revealed that the roots contained 73.90+0.10% carbohydrates, the mean % of fibre and ash contents were >7.0

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Varshney, Kanika, Amit K. Gupta, Ravi Sonkar, et al. "Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Antioxidant and Anti-hyperglycemic Activity." Current Topics in Medicinal Chemistry 18, no. 26 (2019): 2256–65. http://dx.doi.org/10.2174/1568026619666181220112903.

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A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Of the 12 tested, 3 compounds (6c, 7b and 7d) showed good anti-oxidant activity, compound 6c attenuated LDL oxidation by 32%. The compounds 6c and 7d also showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for antiadipogenic and anti-hyperglycemic activity, where 6c showed 44% reduction in lipid accumulation and 20.5% and 24.3% r

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Md, Arifur Rahman Chowdhury, Manirujjaman, and Mazedul Haq Md. "Phytochemical and Pharmacological Activity of Myristica fragrans Houtt (Myristicaceae)." International Journal of Toxicological and Pharmacological Research 9, no. 1 (2017): 56–63. https://doi.org/10.5281/zenodo.12754658.

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Objective: <em>Myristica fragrans </em>Houtt commonly used as traditional medicine for alleviating of various disorders. The purpose of our study was to map out the <em>in vitro </em>antioxidant property and <em>in vivo </em>anti-hyperglycemic and analgesic effect of the methanolic extract of <em>Myristica fragrans </em>Houtt. (Seed and mace) (Myristicaceae) on Swiss albino mice. Methods: The processed powder of <em>Myristica fragrans</em> Houtt (seed and mace) were subjected to methanolic extraction by soxhlet filtration methods, and the desic

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Huh, Hyun Wook, Young-Guk Na, Ki-Hyun Bang, et al. "Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2." Pharmaceutics 12, no. 1 (2020): 49. http://dx.doi.org/10.3390/pharmaceutics12010049.

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Diabetes mellitus (DM) has become a major health problem in most countries of the world. DM causes many complications, including hyperglycemia, diabetic ketoacidosis, and death. In Asia, mulberry has been used widely in the treatment of DM. Combination of drugs with herbal medicine may reduce the unwanted side effects caused by drugs. In this study, the influence of extended mulberry leaves extract (MLE) intake on metformin (Met) was evaluated in terms of pharmacokinetics and pharmacodynamics in DM-induced rats. Three week-treatment of MLE alone produced the anti-hyperglycemic effect (around 2

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Dutta, Jayashree, and Mohan Chandra Kalita. "ANTI HYPERGLYCEMIC EVALUATION OF TERMINALIA CHEBULA LEAVES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 11 (2018): 43. http://dx.doi.org/10.22159/ijpps.2018v10i11.28167.

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Objective: The antihyperglycaemic potentiality of Terminalia chebula leaves has not yet been investigated thoroughly compared to its fruit counterpart. Therefore, the purpose of this study was to assess the hypoglycaemic potentiality of Terminalia chebula Retz leaves both in vitro and in vivo.Methods: Fresh leaves of T. chebula were collected, authenticated and grounded to a fine powder. The powdered material was extracted in methanol. The hypoglycaemic potentiality of the extract was accessed in vitro using enzyme alpha-amylase and alpha-glucosidase. The antihyperglycaemic activity of the met

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Ramakrishna, Ramnarain, Dipayan Sarkar, Munevver Dogramaci, and Kalidas Shetty. "Kefir Culture-Mediated Fermentation to Improve Phenolic-Linked Antioxidant, Anti-Hyperglycemic and Human Gut Health Benefits in Sprouted Food Barley." Applied Microbiology 1, no. 2 (2021): 377–407. http://dx.doi.org/10.3390/applmicrobiol1020026.

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The bioprocessing strategy is an effective approach to improve bioavailability and stability of bioactive compounds for designing functional foods and ingredients. In this study, food barley was bio-transformed to improve functional bioactives by sprouting, coupled with beneficial lactic acid bacteria (LAB)-based fermentation. Dairy Kefir culture with mixed beneficial LAB strains was targeted to ferment aqueous slurries of sprouted hulless food barley flour (unpigmented, purple, and black barley) for 72 h, and modulation of phenolic-linked antioxidant and anti-hyperglycemic functionalities wer

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Ravichandran, R. "Studies on Gymnemic Acids Nanoparticulate Formulations Against Diabetes Mellitus." International Journal of Biomedical and Clinical Engineering 1, no. 2 (2012): 1–12. http://dx.doi.org/10.4018/ijbce.2012070101.

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The solid dosage forms of Gymnemic acid nanoparticulate formulations developed earlier were tested for anti-diabetic activity and hypoglycemic activity. Glucose, insulin and various biochemical parameters were monitored from blood samples of rats to study the efficacy of these formulations. The nano-formulations exhibited significant anti-hyperglycemic activity and produced substantial hypoglycemia. Blood glucose levels (mg/dL) in glucose loaded hyperglycemic rats after dosing with Gymnemic acids nano-formulations were 79 to 98, as against 105 in the control after 3 hours. Hypoglycemic activit

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32

Huang, Hairong, Jiajun Chen, Xiaobo Hu, et al. "Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber." Food & Function 13, no. 5 (2022): 2710–28. http://dx.doi.org/10.1039/d1fo03682c.

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Careen, Liza Pakyntein, Syiem Donkupar, Thabah Daiahun, and Ediemi Sunn Shelareen. "Antioxidant, anti-inflammatory and anti-hyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study." GSC Biological and Pharmaceutical Sciences 16, no. 3 (2021): 145–54. https://doi.org/10.5281/zenodo.5542920.

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Available synthetic antioxidants such as butylated hydroxyl anisole, butylated hydroxyl toluene, propyl gallate, and ascorbic acid exhibit several side effects. To curb these side effects, more effective, less toxic, and cost-effective drugs are required. Therefore, this study aims to screen and evaluate the antioxidant as well as the anti-inflammatory and antidiabetic potential of <em>Houttuynia cordata</em> collected from Mairang village, West Khasi Hills, Meghalaya, India using several standard methods. The aqueous and methanolic extracts of <em>H. cordata</em> were eval

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Wan Nasir, Wan Najiyah Hanun, Nurul Najiha Ain Ibrahim, Kuo Hao Woon, et al. "Effects of Different Drying Methods and Solvents on Biological Activities of Curcuma aeruginosa Leaves Extract." Sains Malaysiana 50, no. 8 (2021): 2207–18. http://dx.doi.org/10.17576/jsm-2021-5008-06.

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Curcuma aeruginosa Roxb. is one of the plants from the Zingiberaceae family which the rhizome has been used for medicinal purposes. However, the biological properties of the leaves have not been fully explored. Therefore, this study was conducted to evaluate the effects of different drying methods and solvents on total phenolic content, antioxidant and anti-hyperglycemic activities of C. aeruginosa leaf extract. Samples were dried by oven drying (OD) and freeze drying (FD), and then extracted using different ratios of ethanol:water (100:0, 50:50 and 0:100). The amount of phenolic content (TPC)

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Animeshchandra, G. M. Haldar, Subhash Chhajed Santosh, Ravindra Ugale Akanksha, J. Kshirsagar Sanjay, Murlidhar Dadure Kanhaiya, and Kar Mahapatra Debarshi. "Design, synthesis, characterization and in vivo studies of some hydroxylated chalcone derivatives as hypoglycemic agents." Journal of Pharmacovigilance and Drug Research 1, no. 1 (2020): 10–14. https://doi.org/10.5281/zenodo.4905485.

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<strong>Abstract: </strong> Low molecular weight ligands (LMWL) have citadel reputation in the modulation of numerous therapeutic targets as a result of their smart uniqueness. The hydroxylated chalcone derivatives have been reported to be therapeutic agents owing to their capability to demonstrate multifarious pharmacological activities, however, their potential in lowering of blood glucose level is not yet explored fully. Corresponding aldehydes and acetophenones were made to react in an alcoholic basic medium to produce the desired chalcone scaffolds. The anti-hyperglycemic potentials

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Duangjai, Acharaporn, Anchalee Rawangkan, Achiraya Siriphap, Anong Kiddee, Noppadon Yosboonruang, and Atchariya Yosboonruang. "A Promising Functional Food for Diabetes Prevention, Antioxidation, and Anti-inflammation of Green Coffee Bean Extract." Journal of Human, Earth, and Future 5, no. 1 (2024): 100–110. http://dx.doi.org/10.28991/hef-2024-05-01-08.

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Functional foods and nutrition have become increasingly popular in preventing and reducing the incidence of diabetes. Green coffee bean extract (GCBE) has received much interest because of the evidence that coffee consumption reduces the risk of diabetes and many inflammatory diseases. This study was designed to investigate the phytochemicals contained in GCBE and their antioxidant, anti-diabetic, and anti-inflammatory efficacies. GCBE phytochemicals were analyzed using high-performance liquid chromatography (HPLC). This analysis demonstrated that chlorogenic acid was the predominant component

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Ajiboye, Basiru O., Oluwafemi A. Ojo, Olivia S. Akuboh, Okesola M. Abiola, Olajumoke Idowu, and Aliyu O. Amuzat. "Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats." Journal of Evidence-Based Integrative Medicine 23 (January 1, 2018): 2515690X1877063. http://dx.doi.org/10.1177/2515690x18770630.

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In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostas

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U., Spandana, Liakhat Ali Shaik, T.Nirmala, M.Santhi, and Sipai Babu SD. "A Review on Tinospora cordifolia." International Journal of Current Pharmaceutical Review and Research 4, no. 2 (2013): 61–68. https://doi.org/10.5281/zenodo.12690568.

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Tinospora cordifolia is a climbing deciduous shrub. It is found throughout tropical part ofIndia and also found in China, Bangladesh, Myanmar & Srilanka. This plant belongs to thefamily Menispermaceae. A variety of constituents have been isolated from different parts ofT.cordifolia. They belong to different classes such as alkaloids, diterpenoid lactones,steroids, glycosides, aliphatic compounds and polysaccharides. T.cordifolia is the bestremedy for children suffering from upper respiratory tact infections. The aqueous extract ofT.cordifolia significantly lowered the serum cholesterol and

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Thilagam, Ellappan, Kumarappan Chidambaram, Chinthamreddy Raviteja, Thalu Vahana, and Parameshwaran Vasudevan. "Anti-hyperglycemic and hypolipidemic effects of Saraca asoca (Roxb.) Wild. flowers in alloxan-treated diabetic rats." Journal of Pharmacy & Pharmacognosy Research 9, no. 1 (2021): 58–68. http://dx.doi.org/10.56499/jppres20.894_9.1.58.

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Context: Saraca asoca (Leguminosae) has been widely used in the Ayurvedic system of medicine for various ailments, and it has been used to treat diabetes as a folk medicine. Aims: To investigate the anti-hyperglycemic and anti-hyperlipidemic effect of ethanolic extracts of S. asoca (EESA) flowers in alloxan-induced diabetic rats. Methods: The anti-hyperglycemic activity of EESA was evaluated by using normal and alloxan-induced (120 mg/kg, i.p.) diabetic rats. In the sub-chronic animal model of diabetes mellitus, EESA was orally administered to normal and alloxan-induced-diabetic rats at doses

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Koussoube, Abdelaziz, Filkpièrè Léonard DA, Maya Doukoure, et al. "Assessment of antioxidant activity and hypoglycemic and anti-hyperglycemic effects of the hydroethanolic extract of the trunk bark of Lannea acida A. Rich. (Anacardiaceae) in male NMRI mice." International Journal of Research in Pharmaceutical Sciences 16, no. 2 (2025): 61–69. https://doi.org/10.26452/ijrps.v16i2.4755.

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Lannea acida A. Rich (Anacardiaceae) is a plant widely used in African traditional medicine to treat various ailments, including diabetes and infertility. This study aimed to evaluate the antioxidant, hypoglycemic, and anti-hyperglycemic activities of the hydroethanolic extract from its trunk bark in male NMRI mice. Antioxidant activity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ferric reducing antioxidant power (FRAP) assays. Hypoglycemic effects were tested in fasting normoglycemic mice divided into five groups (n=5). The anti-hyperglycemic activity was evaluated via an oral

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Sadaf, Rashid, A.Wani Shabir, Ahmad Malla Ishfaq, et al. "Mulberry: A Versatile Plant, its Potential Applications in different Industries." International Journal of Environmental & Agriculture Research (IJOEAR) 11, no. 1 (2025): 01–08. https://doi.org/10.5281/zenodo.14760106.

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Mulberry is a deciduous, perennial plant that grows quickly in a variety of climatic, topographical, and soil conditions. The mulberry plant's rich constituents have led to its extensive application in a range of businesses. Mulberry has long been used as a functional food due to its high concentration of phytochemical components. Mulberry fruits are difficult to preserve due to their high water content; as a result, many value-added goods such as syrups, wines, teas, squashes, jams, breads, jellies and köme, pekmez (turkish by-products), yogurts, vinegar, parathas, biscuits, and many mor

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Lachowicz, Sabina, Rafał Wiśniewski, Ireneusz Ochmian, Katarzyna Drzymała, and Stanisław Pluta. "Anti-Microbiological, Anti-Hyperglycemic and Anti-Obesity Potency of Natural Antioxidants in Fruit Fractions of Saskatoon Berry." Antioxidants 8, no. 9 (2019): 397. http://dx.doi.org/10.3390/antiox8090397.

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The aim of the present work was to evaluate for content of phytochemicals (monophosphate nucleotides, free amino acids, polyphenols), and for anti-microbiological, anti-diabetic (ability to inhibit pancreatic lipase, α-glucosidase, and α-amylase), and antioxidant activities in seven selected fruit and fruit fractions of Amelanchier alnifolia. Most of the fruit and fruit fractions analyzed in this study have not been examined in this respect until now. The content of monophosphate nucleotides and free amino acids were tested by ultra-performance liquid chromatography coupled with photodiode arr

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Sharma, Rohit, Vijay Kumar, BK Ashok, R. Galib, PradeepKumar Prajapati, and B. Ravishankar. "Hypoglycemic and anti-hyperglycemic activity of Guduchi Satva in experimental animals." AYU (An International Quarterly Journal of Research in Ayurveda) 34, no. 4 (2013): 417. http://dx.doi.org/10.4103/0974-8520.127726.

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El Hawary, Seham S., Soumaya Saad, Ali Mahmoud El Halawany, Zeinab Y. Ali, and Mahitab El Bishbishy. "Phenolic content and anti-hyperglycemic activity of pecan cultivars from Egypt." Pharmaceutical Biology 54, no. 5 (2015): 788–98. http://dx.doi.org/10.3109/13880209.2015.1080732.

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Essmat, Nariman, Eman Soliman, Mona F. Mahmoud, and Amr A. A. Mahmoud. "Antidepressant activity of anti-hyperglycemic agents in experimental models: A review." Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14, no. 5 (2020): 1179–86. http://dx.doi.org/10.1016/j.dsx.2020.06.021.

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Youn, Ji-Youn, Hyo-Young Park та Kyung-Hea Cho. "Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase". Diabetes Research and Clinical Practice 66 (грудень 2004): S149—S155. http://dx.doi.org/10.1016/j.diabres.2003.08.015.

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Zhao, Guijun, Xia Li, Wansheng Chen, Zhongxin Xi, and Lianna Sun. "Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity." Fitoterapia 83, no. 8 (2012): 1590–97. http://dx.doi.org/10.1016/j.fitote.2012.09.007.

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Sato, Hiroyuki, Cédric Genet, Axelle Strehle, et al. "Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea." Biochemical and Biophysical Research Communications 362, no. 4 (2007): 793–98. http://dx.doi.org/10.1016/j.bbrc.2007.06.130.

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Mali, Rohit P., Priya S. Rao, and R. S. Jadhav. "A Review on Pharmacological Activities of Calotropis Procera." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 947–51. http://dx.doi.org/10.22270/jddt.v9i3-s.2870.

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The plant Calotropis procera (Aiton) Dryand belong to the Apocynaceae family it is popularly known as “Rui” in Marathi, “ Mudar” in hindi other common name include Rubber Bush, Apple of sodom. (India & Pakistan). The bark and leaves are known to show wound healing, shows anti-Hyperglycemic effect, Analgesic, Anti pyretic, neuromuscular blocking activity, Purgative, anti-cancer activities. The phytochemistry of plant reveals presence of triterpenoids, flavonoids, cardiac glycosides, cardenolides, anthocyanins, α-amyrin, β-amyrin, lupeol, β-sitosterol, flavanols, mudarine, resins, a powerful

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Pyae Phyo Win, Thurein Lynn, Htin Lin Naing Soe, Kyaw Zwar Htoon, and Khin Ohnmar Kyaing. "The antihyperglycemic activity of leaves of Leptadenia reticulata Wight & Arn. (Goan-kha) on adrenaline-induced hyperglycemic rats." GSC Biological and Pharmaceutical Sciences 31, no. 2 (2025): 085–92. https://doi.org/10.30574/gscbps.2025.31.2.0170.

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Background: In Myanmar, the leaves of Leptadenia reticulata Wight & Arn. (locally known as Goan-kha) are traditionally used for their purported anti-hyperglycemic effects. However, scientific validation of these effects remains limited. Objective: To evaluate the anti-hyperglycemic activity of a 70% ethanolic extract of Leptadenia reticulata Wight & Arn. leaves in an adrenaline-induced hyperglycemia model in rats. Method: A laboratory-based experimental study was conducted using thirty Wistar rats (180–220 g), which were randomly assigned into five groups (n = 6 per group): a normal co

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