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Journal articles on the topic 'Anti- Hypertensive Activity'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Odimegwu, Joy I., Oluwakayode Ezekiel Olatunji, Tolulope F. Okanlawon, and Ishola Ismail. "Diuretic and Anti-Hypertensive Activity of Clerodendrum Chinense (OSBECK) MABB. Aqueous Extract in 8% Salt Diet-Induced Hypertensive Rats." Advancements in Journal of Urology and Nephrology 6, no. 1 (2024): 01–10. http://dx.doi.org/10.33140/ajun.06.01.03.

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Diuresis refers to an increase in the rate of urine flow and sodium excretion from the system via the urine. It is a necessary excretory process that may prove difficult for some disease systems e.g. enlarged prostates. Hypertension occurs as a result of systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg. It is one of the most common chronic diseases affecting more than a billion people worldwide. A high dietary sodium intake is one of the factors associated with the development of hypertension. Clerodendrum chinensis is used by local communities in

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Shrivastava, Birendra, Parveen Kumar, Madan Mohan Gupta, and Anil Kumar Sharma. "Anti-Hypertensive Activity of Timolol Maleate Nanoparticle Loaded Transdermal Patch on Dexamethasone Induced Hypertensive Rats." Asian Pacific Journal of Health Sciences 6, no. 2 (2019): 145–51. http://dx.doi.org/10.21276/apjhs.2019.6.2.21.

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3

Wilson, J., M. A. Orchard, A. A. Spencer, J. A. Davies, and C. R. M. Prentice. "Anti-Hypertensive Drugs Non-Specifically Reduce “Spontaneous” Activation of Blood Platelets." Thrombosis and Haemostasis 62, no. 02 (1989): 776–80. http://dx.doi.org/10.1055/s-0038-1646901.

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SummaryAbnormal activation of blood platelets may be a contributory factor in the accelerated vascular disease which occurs in hypertension. We investigated the effects of lowering blood pressure in 12 patients with mild hypertension on several aspects of platelet function, initially in a placebo-controlled, double-blind, crossover study with nisoldipine, and subsequently in the same patients comparing nisoldipine with the patients’ usual anti-hypertensive therapy. Values were compared with those from an age, sex-matched control population. Seven hypertensive patients with renal failure were a

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4

Khanal, Hari, Ram Kishor Joshi, and Abhishek Upadhyay. "Anti- hypertensive activity of Ayurvedic medicinal plants." International Journal of Complementary and Alternative Medicine 13, no. 1 (2020): 7–12. http://dx.doi.org/10.15406/ijcam.2020.13.00485.

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Misal, A. R.* Maske Vaishnavi S. Pare Rutuja U. Kharat Anjali S. "Anti- Hypertensive Activity Of Ginger, Cardamom, Garlic." International Journal of Pharmaceutical Sciences 2, no. 3 (2024): 613–27. https://doi.org/10.5281/zenodo.10835119.

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Blood pressure is caused by another medical condition or use of certain medicine. It usually gets better after you treat that condition or stop taking medicines that are causing it Antihypertensive drug therapy has been remarkable improved in the last 60 years received different classes of drugs have received prominence with passage of time in this period. Before 1950 hardly any effective and toleratad antihypertensive was available .There is majer risk factors of hypertension are High sodium (salt)" overweight & obesity physical inactivity According to world health organisation Imperical

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Sitepu, Sari Desi Esta Ulina, Selamat Tuahta Sipayung, and Edi Kristianta Tarigan. "Socialization Of Compliance In Taking Antihypertension Medication At Karang Anyer Community Health Center." JURNAL PENGMAS KESTRA (JPK) 4, no. 2 (2024): 289–93. https://doi.org/10.35451/jpk.v4i2.1995.

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Hypertension is a type of disease whose treatment requires patients to take medication for a long period of time, even for life. This disease can cause new diseases or various complications. So that this does not happen, a good level of compliance with the consumption of anti-hypertension drugs is needed in hypertension sufferers. By taking anti-hypertension medication you can stop the disease and normalize blood pressure levels. Compliance with treatment for hypertensive patients is the main key because hypertension is a disease that must be continuously controlled or managed so as not to cau

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Silva, Maisa Gomes da, Sara Léa Fortes Barbosa, Diego Santos Silva, et al. "Bioactive Natural Products against Systemic Arterial Hypertension: A Past 20-Year Systematic and Prospective Review." Evidence-Based Complementary and Alternative Medicine 2022 (June 20, 2022): 1–21. http://dx.doi.org/10.1155/2022/8499625.

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Background. Systemic arterial hypertension is one of the most common cardiovascular risks, corresponding to 45% of deaths involving CVDs. The use of natural products, such as medicinal plants, belongs to a millennial part of human therapeutics history and has been employed as an alternative anti-hypertensive treatment. Objective. The present review aims to prospect some natural products already experimentally assayed against arterial hypertension through scientific virtual libraries and patent documents over the past 20 years. Search strategy. This is a systematic review of the adoption of the

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K, Sujeethasai, Manoharan A та Santhanakumar M. "Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats". International Journal of Research and Review 8, № 5 (2021): 110–15. http://dx.doi.org/10.52403/ijrr.20210516.

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Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects. Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats. Study design: Observational in-vivo study Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil,

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Rahul, Kashyap1 Shivaji Patel2 Chandraprabha Dewangan*3 GyaneshKumar Sahu4. "Acorus Calamus: An Ancient Remedy with Modern Medicinal Applications." International Journal of Scientific Research and Technology 2, no. 2 (2025): 140–48. https://doi.org/10.5281/zenodo.14892736.

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The aim of the paper is provided information regarding incredible medicinal herb AcorusCalamus and its extract has various medicinal benefits like Anti diabetic activity, anti hypertensive effect, cytotoxic effect , immunosuppressive activity , antifungal activity , analgesic and anticonvulsant effect, bronchodilatory activity , licicidal activity, wound healing activity, coronary vasodilator effect, anti-cancer activity.The phytochemical constituent present in extract of oil are a-asarone, b-asarone, c-asarone, calamine, calamenenol, calameone, a-pinene,b-pinene, camphene, p-cymene, eugenyl a

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10

Li, Chia-Cheng, Yu-Chen Lee, Hsin-Yi Lo, Yu-Wen Huang, Chien-Yun Hsiang, and Tin-Yun Ho. "Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition." Molecules 24, no. 10 (2019): 1886. http://dx.doi.org/10.3390/molecules24101886.

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Corn silk tea has been used in folk medicine for anti-hypertensive healthcare. Angiotensin-converting enzyme (ACE) plays a crucial role on the homeostasis of blood pressure. However, effects of corn silk tea on ACE activity and the presence of ACE inhibitory constituents in corn silk are still unknown. Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE). CSE significantly reduced systolic blood pressure (SBP) levels in spontaneously hypertensive rats and inhibited the ACE act

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11

Goyal, Anju, Jitender Singh, and Dharam Pal Pathak. "Synthesis and Pharmacological Evaluation of Some Novel Imidazole Derivatives for Their Potential Anti-Hypertensive Activity." Journal of Pharmaceutical Technology, Research and Management 1, no. 1 (2013): 69–79. http://dx.doi.org/10.15415/jptrm.2013.11005.

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12

J., Rajan, Sakthibalan M., Gerard Marshall Raj, and Mangaiarkkarasi A. "Knowledge, attitude and practice of hypertension among hypertensive patients in a tertiary care teaching hospital." International Journal of Basic & Clinical Pharmacology 8, no. 5 (2019): 1013. http://dx.doi.org/10.18203/2319-2003.ijbcp20191593.

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Background: Hypertension is a chronic disease and an important risk factor for cardiovascular complications. The increase in prevalence of hypertension is attributed to age of population, urbanization, sedentary habits, lack of physical activity, obesity, alcohol consumption and exposure to continuous stress. Regular anti-hypertensive medications can reduce the long-term risk of cardiovascular morbidity and mortality. This study was done to assess the knowledge, attitude and practice regarding hypertension and to assess the drug compliance in hypertensive patients.Methods: This study was a cro

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Li, Daxiang, Ruru Wang, Jinbao Huang, et al. "Effects and Mechanisms of Tea Regulating Blood Pressure: Evidences and Promises." Nutrients 11, no. 5 (2019): 1115. http://dx.doi.org/10.3390/nu11051115.

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Cardiovascular diseases have overtaken cancers as the number one cause of death. Hypertension is the most dangerous factor linked to deaths caused by cardiovascular diseases. Many researchers have reported that tea has anti-hypertensive effects in animals and humans. The aim of this review is to update the information on the anti-hypertensive effects of tea in human interventions and animal studies, and to summarize the underlying mechanisms, based on ex-vivo tissue and cell culture data. During recent years, an increasing number of human population studies have confirmed the beneficial effect

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14

Sanou, Abdoudramane, Kiessoun Konaté, Lazare Belemnaba, et al. "In Vivo Diuretic Activity and Anti-Hypertensive Potential of Hibiscus sabdariffa Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes." Foods 13, no. 4 (2024): 534. http://dx.doi.org/10.3390/foods13040534.

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Aqueous extracts of calyx from Hibiscus sabdariffa (HS) (roselle) are highly appreciated for their nutritional and therapeutic effects, especially as anti-hypertensive substances. This study aimed to evaluate their anti-hypertensive potential through an in vitro inhibition assay of angiotensin-converting enzyme (ACE) and hypertension precursor enzymes and to assess the in vivo diuretic activity of HS. Results showed that HS extract inhibited enzymes belonging to several classes, such as α-amylase, trypsin, chymotrypsin, xanthine oxidase, lipoxygenase, and angiotensin-converting enzyme. In part

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15

Vaijayanthi, S. Parimala, and N. Mathiyalagan. "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide." International Letters of Chemistry, Physics and Astronomy 26 (January 2014): 1–8. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.26.1.

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

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Vaijayanthi, S. Parimala, and N. Mathiyalagan. "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide." International Letters of Chemistry, Physics and Astronomy 26 (January 24, 2014): 1–8. http://dx.doi.org/10.56431/p-2swj0a.

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

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17

Nguyen, Thi Thanh Loan, Thi Van Anh Pham, and Thi Xoan Le. "Standardised flavonoid extract from Diospyros kaki L.f leaves alleviates high blood pressure and ventricular hypertrophy on cortisone acetate-induced hypertensive rats." Ministry of Science and Technology, Vietnam 65, no. 3 (2023): 80–84. http://dx.doi.org/10.31276/vjste.65(3).80-84.

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The current study was designed to investigate the anti-hypertensive effects of a standardised flavonoid extract from Diospyros kaki L.f leaves (DK extract) on cortisone acetate-induced hypertensive rats. Hypertension was induced in Wistar rats by subcutaneously injecting 2.5 mg cortisone acetate daily and by maintaining the rats on a 1% sodium chloride diet for a period of 28 days. The hypertensive rats were treated daily with DK extract (50 and 100 mg/kg of body weight; p.o.) or captopril (20 mg/kg of body weight; p.o.), a reference drug, for 14 consecutive days. The blood pressure and heart

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18

Temperilli, Aldemio, Daniela Ruggieri, and Patricia Salvati. "Anti-hypertensive activity of ergolinyl-ureido and thioureido derivatives." European Journal of Medicinal Chemistry 23, no. 1 (1988): 77–81. http://dx.doi.org/10.1016/0223-5234(88)90170-5.

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19

Gouda, Moustafa A., Hatem E. Gafer, and Mohamed Gouda. "Synthesis and anti-hypertensive activity of novel sulphadimidine derivatives." Medicinal Chemistry Research 21, no. 11 (2011): 3902–6. http://dx.doi.org/10.1007/s00044-011-9935-3.

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20

Putri, Veni Dayu, Rizka Febtrina, Rahmi Pramulia Fitri, Dea Andarista, and Monica Juliyanti. "Education and Training on Making Anti-Hypertensive Basil Jelly in The Area of Health Centre Rawat Inap Karya Wanita of Pekanbaru." Dinamisia : Jurnal Pengabdian Kepada Masyarakat 8, no. 4 (2024): 1086–92. https://doi.org/10.31849/dinamisia.v8i4.16594.

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Hypertension is a cardiovaskuler disease characterized by systolic blood pressure ≥140mmHg and diastolic blood pressure ≥90mmHg. Hypertension requires continuous management as it can lead to complications such as stroke and coronary heart disease. This community engagement activity was conducted at the Lembah Damai Subdistrict Health Center in Lembah Damai Village, Pekanbaru City in September 2023. The purpose of the activity is to empower participants by increasing their knowledge and skills in the non-pharmacological management of hypertension using basil plant. The engagement activity was c

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21

Silva, Henrique, and Rita Bárbara. "Exploring the Anti-Hypertensive Potential of Lemongrass—A Comprehensive Review." Biology 11, no. 10 (2022): 1382. http://dx.doi.org/10.3390/biology11101382.

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Lemongrass (Cymbopogon citratus (DC) Stapf) is a herb commonly used in folk medicine for many purposes. However, its anti-hypertensive potential has not yet been thoroughly studied. This paper reviews the anti-hypertensive effects of both lemongrass and its main compound citral in in vitro, ex vivo, preclinical and clinical studies. Lemongrass essential oil contains terpenes and their derivatives, whereas extracts contain different classes of polyphenols. Both citral and lemongrass display vasorelaxant activity ex vivo, acting by the promotion of endothelial nitric oxide/prostanoids secretion

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22

Lee, Hyo-Geun, Jae-Young Oh, Dong-Min Chung, et al. "Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities." Marine Drugs 20, no. 6 (2022): 346. http://dx.doi.org/10.3390/md20060346.

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Aquacultured fish are the richest natural source of protein. However, their overproduced biomass is often discarded due to production imbalance, causing considerable losses to the fishery industry. Therefore, it is necessary to utilize surplus fish and add value to overproduced fish. We performed complex enzyme-assisted hydrolysis to determine the correlation between its physical characteristics and anti-hypertensive activity in vitro and in vivo using an SHR model. Protamex-Pepsin assisted hydrolysate from Paralichthys olivaceus (POppH) produced by complex enzyme-assisted hydrolysis contained

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23

Stevenson, John C. "A new hormone replacement therapy containing a progestogen with anti-mineralocorticoid activity." British Menopause Society Journal 12, no. 1_suppl (2006): 8–10. http://dx.doi.org/10.1258/136218006775992167.

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Drospirenone is a new progestogen in hormone replacement therapy, with anti-mineralocorticoid activity. This anti-mineralocorticoid activity counteracts water and sodium retention, helping to reduce the likelihood of fluid retention that some women experience with hormone replacement therapy. In a post hoc analysis of women with mild hypertension, estradiol (1 mg) plus drospirenone (2 mg) was found to lower blood pressure in mildly hypertensive women. The introduction of estradiol plus drospirenone may offer the opportunity to re-evaluate the contribution of the progestogen component of hormon

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Siska, Siska, Endang Hanani, Tahyatul Bariroh, et al. "Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats." Journal of Herbmed Pharmacology 12, no. 3 (2023): 448–52. http://dx.doi.org/10.34172/jhp.2023.50.

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Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti-inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes; However, no scientific evaluation of its antihypertensive activity has been conducted. The purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE) on male rats’ blood pressure, urine volume, and sodium and potassium levels. Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension. A non-invasive tail method was used to measure

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Masheta, Dhafir Qahtan, Shafq Kadhim Al-Azzawi, and Sharara Fadhil Abbood. "Anti-inflammatory activity of anthocyanin extract on diabetic and hypertensive patients." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 68–74. http://dx.doi.org/10.15587/2519-4852.2023.272061.

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Anthocyanins pigments are a major class of plant phenolic components, flavonoids‎. The distinctive purple or red colours of many fruits and vegetables are attributed to the presence of these flavonoids‎. They are highly water-soluble pigments and have been well known to possess general health-promoting characteristics. The aim: This study aimed to evaluate the anti-inflammatory and antioxidant activity of anthocyanin extract. It also looked at how the extract consumption affected people with hypertension and diabetes in terms of lowering blood pressure and blood glucose levels and in preventin

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Festa, Marco, Clementina Sansone, Christophe Brunet, et al. "Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection." International Journal of Molecular Sciences 21, no. 21 (2020): 8364. http://dx.doi.org/10.3390/ijms21218364.

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Growing interest in hypertension—one of the main factors characterizing the cardiometabolic syndrome (CMS)—and anti-hypertensive drugs raised from the emergence of a new coronavirus, SARS-CoV-2, responsible for the COVID19 pandemic. The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Several classes of synthetic drugs are available for hypertension, rarely associated with severe or mild adverse effects. New natural compounds, such as peptides, might be useful to t

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Badejo, J. A., O. S. Michael, M. O. Adetona, et al. "Mechanisms of anti-hypertensive activity of methanol leaf extract and fractions of Persea americana Mill. (Lauraceae) in rats." Nigerian Journal of Pharmaceutical Research 18, no. 1 (2022): 63–74. http://dx.doi.org/10.4314/njpr.v18i1.7.

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Background: Persea americana has been identified to possess antihypertensive properties, but the mechanisms of these properties remain unclear. This study was thus designed to elucidate the mechanisms of anti-hypertensive activity of the extract and fractions of fresh leaf of Persea americana on hypertension induced in rats.Methods: Crude methanol leaf extract of P. americana was partitioned into n-butanol, dichloromethane, chloroform, hexane and ethyl acetate. The ethyl acetate fraction was further purified through column chromatography. Doses of the extract and column fraction were tested fo

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Dhafir, Qahtan Masheta, Kadhim Al-Azzawi Shafq, and Fadhil Abbood Sharara. "Anti-inflammatory activity of anthocyanin extract on diabetic and hypertensive patients." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 68–74. https://doi.org/10.15587/2519-4852.2023.272061.

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Anthocyanins pigments are a major class of plant phenolic components, flavonoids<em>&lrm;</em>. The distinctive purple or red colours of many fruits and vegetables are attributed to the presence of these flavonoids<em>&lrm;</em>. They are highly water-soluble pigments and have been well known to possess general health-promoting characteristics. <strong>The aim:</strong> This study aimed to evaluate the anti-inflammatory and antioxidant activity of anthocyanin extract. It also looked at how the extract consumption affected people with hypertension and diabetes in terms of lowering blood pr

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Oridupa, Olayinka, Temidayo Olutayo Omobowale, Ademola Adetokunbo Oyagbemi, et al. "Antioxidant activity enhancement and oxidative damage inhibition by Lagenaria breviflora fruit and Xanthosoma sagittifolium corm in hypertensive Wistar rats." Nigerian Journal of Physiological Sciences 38, no. 1 (2023): 101–6. http://dx.doi.org/10.54548/njps.v38i1.14.

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Cardiovascular diseases are the leading causes of mortality in the world today with hypertension being the major clinical presentation of these diseases. This study assessed the anti-hypertensive effects of Lagenaria breviflora whole fruit and Xanthsoma sagittifolium corms in experimentally inudced hypertensive Wistar rats. The ability of the plants to ameliorate oxidative damage accompanying hypertension was evaluated using changes in oxidative stress markers as well as monitoring of cardiovascular parameters. Hypertension was induced by intraperitoneal injection of DOCA salt twice weekly and

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B., Rajitha* B. Rashmitha S. Ashwini K. Neha N. Prasad M. Ashwini. "An Overview on Synthesis, Properties and Biological Activities of Imidazole and Its Derivatives." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2444–53. https://doi.org/10.5281/zenodo.15083575.

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Imidazole belongs to the class of five membered heterocyclic compounds which plays a major role in Medicinal Chemistry. It was synthesized by different methods using different chemicals. This article reviews different methods of synthesis, properties of imidazole, both its natural and synthetic derivatives and pharmacological activities. Imidazole shows wide variety of biological activities such as anti-tubercular activity, anti-inflammatory activity, antimicrobial activity, anthelmintic activity, anti-cancer activity etc., this article reflects on anti-tubercular activity, anti-inflammatory a

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Kang, Dae Gill, Yong Gab Yun, Jang Hyun Ryoo, and Ho Sub Lee. "Anti-Hypertensive Effect of Water Extract of Danshen on Renovascular Hypertension Through Inhibition of the Renin Angiotensin System." American Journal of Chinese Medicine 30, no. 01 (2002): 87–93. http://dx.doi.org/10.1142/s0192415x02000107.

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A study was designed to elucidate the mechanism of anti-hypertensive effects of Danshen in the two-kidney, one clip (2K1C) Goldblatt renovascular hypertensive model, which is the renin-angiotensin system (RAS)-dependent hypertensive model. We investigated the effects of water extracts of Danshen on the angiotensin converting enzyme (ACE) activities, systolic blood pressure (SBP), and hormone levels in the plasma of 2K1C rats. ACE activity was inhibited by the addition of Danshen extract in a dose-dependent manner. SBP was decreased significantly after administration of Danshen extract in 2K1C,

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Fhania, Gloriana Tio, Intan Asri Nurani, and Diah Argarini. "Analisis Asuhan Keperawatan melalui Intervensi Senam Anti-Hipertensi pada Keluarga dengan Diagnosa Medis Hipertensi di Kelurahan Jati Padang." Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) 5, no. 12 (2022): 4179–85. http://dx.doi.org/10.33024/jkpm.v5i12.7597.

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ABSTRAK Hipertensi adalah keadaan pada seseorang dimana terjadinya peningkatan tekanan darah yang melebihi batas normal yang telah ditentukan yaitu sistolik ≥ 140 mmHg dan diastolik ≥ 90 mmHg. Gaya hidup merupakan faktor utama yang meningkatkan penyakit hipertensi, salah satu penyebabnya adalah kurang dalam melakukan aktifitas fisik, seperti olahraga. Salah satu aktifitas fisik atau olahraga yang bisa dilakukan pada penderita hipertensi adalah senam anti hipertensi. Senam anti-hipertensi merupakan olahraga yang salah satunya bertujuan untuk meningkatkan aliran darah dan pasokan oksigen ke dala

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AK, Oyebamiji, and Semire B. "STUDIES OF ANTI-HYPERTENSIVE ACTIVITY OF 1, 4-DIHYDROPYRIDINE DERIVATIVES: COMBINATIONS OF DFT-QSAR AND DOCKING APPRAOCHES." Bulletin of Pharmaceutical Research 6, no. 3 (2016): 105–13. http://dx.doi.org/10.21276/bpr.2016.6.3.4.

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34

Rossi, T., M. Baraldi, C. Parenti, L. Costantino, and M. Di Bella. "Anti-hypertensive activity of some 1,2,4-benzothiadiazine-1,1-dioxide derivatives." Pharmacological Research 22 (September 1990): 433. http://dx.doi.org/10.1016/s1043-6618(09)80442-8.

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Yamada, Yuko, Keito Nishizawa, Megumi Yokoo, et al. "Anti-hypertensive activity of genetically modified soybean seeds accumulating novokinin." Peptides 29, no. 3 (2008): 331–37. http://dx.doi.org/10.1016/j.peptides.2007.11.018.

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Dâmaso, A., N. Tavares, and G. França. "Adherence to anti-hypertensive treatment according to physical activity levels." Journal of Science and Medicine in Sport 15 (December 2012): S160. http://dx.doi.org/10.1016/j.jsams.2012.11.390.

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Haynes, Alexandria Porcia, Selam Desta, Taseer Ahmad, et al. "The Antioxidative Effects of Flavones in Hypertensive Disease." Biomedicines 11, no. 11 (2023): 2877. http://dx.doi.org/10.3390/biomedicines11112877.

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Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality in the United States. Excess dietary salt consumption, which is a catalyst of hypertension, initiates an inflammatory cascade via activation of antigen-presenting cells (APCs). This pro-inflammatory response is driven primarily by sodium ions (Na+) transporting into APCs by the epithelial sodium channel (ENaC) and subsequent NADPH oxidase activation, leading to high levels of oxidative stress. Oxidative stress, a well-known catalyst for hypertension-related illness development, disturbs redox homeosta

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Iwalokun, Bamidele A., Sedoten A. Hodonu, Stella Nwoke, Olabisi Ojo, and Phillip U. Agomo. "Evaluation of the Possible Mechanisms of Antihypertensive Activity ofLoranthus micranthus: An African Mistletoe." Biochemistry Research International 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/159439.

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Loranthus micranthus (LM), also called African mistletoe is a major NigerianLoranthaceaeplant used traditionally to treat hypertension. The methanolic leaf extract of the plant (LMME) has been shown to elicit anti-hypertensive activity in rats but mechanism remains unclear. This study was undertaken to study the effect of LM on pressor-induced contraction of rat aorta smooth muscles and serum lipid profiles in mice. The LMME was partitioned to produce n-butanol (NBF-LMME), chloroform (CF-LMME), ethyl acetate (EAF-LMME) and water (WF-LMME) fractions. The median effective concentrations and maxi

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Ishak, Amirah, Nurul Sjafie, Norhaizan Esa, and Hasnah Bahari. "Lipid and Blood Pressure Lowering Effects of Mikania micrantha Through En-zymatic Inhibition." Journal of Tropical Life Science 13, no. 2 (2023): 277–86. http://dx.doi.org/10.11594/jtls.13.02.05.

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Mikania micrantha Kunth (Asteraceae) is a plant traditionally used to reduce the risk of hyperlipidemia and hypertension. There is limited information on the anti-hyperlipidemic and anti-hypertensive effects of the various M. micrantha leaves and stem extracts. This study aimed to examine the in vitro potential of different parts of M. micrantha (leaves and stem) extracts in inhibiting hyperlipidemia-related enzymes, i.e., pancreatic lipase (PL), lipoprotein lipase (LPL) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), in addition to the hypertension-related, i.e., angiotensin-I con

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Gupta, Ena, Uroosa Noor, Shashi Soni, and Neelesh Kumar Maurya. "Therapeutic efficacy of Punica granatum peel in the prevention of hypertension." International Journal of Agricultural Invention 8, no. 1 (2023): 144–47. https://doi.org/10.46492/ijai/2023.8.1.18.

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Pomegranate is scientifically known as Punica granatum, extensively cultivated in India that generates million tons of fruit waste mainly peel and pomace annually. Pomegranate peel is a rich source of bioactive compounds as compared to other part of the fruit. Major bioactive compounds present in the peel are ellagic acid, gallic acid, punicalagin, tannins, flavonoids etc. that have the potential to provide many therapeutic applications such as antihypertensive, anti-aging, anti-cancer, anti-inflammatory properties and many more. Hypertension is connected with many diseases such as cardiovascu

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Oh, Jae-Young, Jun-Geon Je, Hyo-Geun Lee, et al. "Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (Paralichthys olivaceus) Surimi." Foods 9, no. 5 (2020): 647. http://dx.doi.org/10.3390/foods9050647.

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There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flo

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Wu, Yanling, Ming Fang, Lei Du, et al. "The nutritional composition and anti-hypertensive activity on spontaneously hypertensive rats of sipuncula Phascolosoma esculenta." Food & Function 5, no. 9 (2014): 2317. http://dx.doi.org/10.1039/c4fo00416g.

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Rizos, Evangelos C., Athanasia Spyrou, Evangelos N. Liberopoulos, et al. "Effects of Eprosartan on Serum Metabolic Parameters in Patients with Essential Hypertension." Open Cardiovascular Medicine Journal 1, no. 1 (2007): 22–26. http://dx.doi.org/10.2174/1874192400701010022.

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The effect of the anti-hypertensive drug eprosartan on metabolic parameters is currently not extensively documented. We evaluated the effect of eprosartan on parameters involved in atherogenesis, oxidative stress and clotting activity. This open-label unblinded intervention study included 40 adult patients with essential hypertension taking eprosartan. Eprosartan significantly reduced by 8% (p<0.001) the systolic and by 13% (p<.001) the diastolic blood pressure, and in-creased by 24% the time needed to produce oxidative by-products (p=0.001), a marker of oxidative stress. In contrast, ep

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Muharni, M., J. Julinar, H. Yohandini, F. Fitrya, and R. Melati. "In vitro anti-cholesterol and anti-hypertensive activity of stem bark the Flacourtia rukam." IOP Conference Series: Earth and Environmental Science 713, no. 1 (2021): 012056. http://dx.doi.org/10.1088/1755-1315/713/1/012056.

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Matheswaran, Parameswaran, Latha Raja, and Sharmila Banu Gani. "Anti-hypertensive and anti-microbial activity of protein hydrolysate obtained from seven edible insects." Bulletin of Pure & Applied Sciences- Zoology 39a, no. 1 (2020): 206. http://dx.doi.org/10.5958/2320-3188.2020.00024.8.

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Jyoti, Thakur*. "An Overview on Pharmacological Activities of Silybum Marianum (Milk Thistle)." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1820–28. https://doi.org/10.5281/zenodo.15385799.

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This review on S. marianum, a plant widely used in traditional European medicine, provides an account of its botany, the chemistry of silymarin, and its main constituent silybin, and other compounds; analytical methods for silymarin and its isomers; pharmacology of silymarin and silybin. For many years, milk thistle (Silybum marianum) has been used as a herbal cure for a variety of illnesses. A complex blend of flavonolignans, including silibinin (silybin), silychristin, and silydianin, makes up the main active ingredient silymarin. In recent years, milk thistle leaves extract has been widely

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Rahmawati, Irma Sarita, Soetjipto Soetjipto, Annis Catur Adi, Aulanni’am Aulanni’am, and Annisa Rizky Maulidiana. "Potensi Ekstrak Etanol Ubi Jalar Ungu sebagai Inhibitor Angiotensin Converting Enzyme pada Tikus Hipertensi." Indonesian Journal of Human Nutrition 8, no. 1 (2021): 88. http://dx.doi.org/10.21776/ub.ijhn.2021.008.01.9.

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<p>There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanin found in purple sweet potato generates bioactive compound with antihypertensive and anti-ACE activities in RAA system. The present study sought to investigate anti-ACE activities in RAA system of extract ethanol of purple sweet potato (EP) in deoxycorticosterone acetate (DOCA–salt)–induced hypertensive rats (<em>Rattus norvegicus</em>). The rats

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Liu, Hua, Ze-Ming Liang, Rui-ting Li, and Yi-Gang Yu. "Advances in the mechanisms of Hibiscus sabdariffa L. on hypertension." E3S Web of Conferences 145 (2020): 01039. http://dx.doi.org/10.1051/e3sconf/202014501039.

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As a traditional edible beverage and medicinal application for high-pressure blood treatment with no side effects, Hibiscus sabdariffa L. (HS) has high prospect to be nutraceuticals as diet additive for anti-hypertension. The anti-hypertension effect of HS has also been scientific validated recently especially in diabetic patient and post-partum mothers. In this paper, we reviewed up-to-date mechanisms found for the anti-hypertensive effect of HS extracts. Those included the inhibition of angiotensin-converting enzymes (ACE) activity, diuretic effect, endothelium-derived nitric oxide-cGMP-rela

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Jannath, Sanjida, Bushratul Jannat, Syeda Taarin Ishraat, et al. "An Assessment of Antihypertensive & Anti-hyperlipidemic Activity of Allium sativum and Rauwolfia serpentine in Hypertension and High Fat Induced Rat Model." Asian Journal of Advanced Research and Reports 17, no. 11 (2023): 185–92. http://dx.doi.org/10.9734/ajarr/2023/v17i11564.

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Introduction: Hypertension (high blood pressure) is an increasingly important global medical and public health problem that is linked to a higher risk of developing cardiovascular disease. Researchers in both developed and developing nations have identified it as one of the most widespread diseases currently present. The investigators are focusing on plants for better, safer, more affordable, and more effective alternatives due to unwanted risks and negative effects of synthetic pharmaceuticals. Allium sativum possesses anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosc

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Gultom, Agustina Boru, and Arbani Batubara. "FACTORS ASSOCIATED WITH THE QUALITY OF LIFE OF HYPERTENSION PATIENTS." Journal of Law and Sustainable Development 12, no. 6 (2024): e3710. http://dx.doi.org/10.55908/sdgs.v12i6.3710.

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Objective: This study aimed to analyze factors related to the quality of life of hypertensive patients in the working area of the Mulyorejo Community Health Center, Deli Serdang Regency. Theoretical Framework: Complications of hypertension and variables related to the quality of life of hypertensive patients have a major impact on the burden borne by various parties including patients, the economic burden, society and health services. Method: This study used an explanatory survey design, with a population of all hypertensive patients seeking treatment in the working area of the Mulyorejo Commu

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