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Journal articles on the topic 'Anti-hypertensive Drug'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Bhandary, Apeksha, and Prasan R. Bhandari. "Drug usage pattern of anti-hypertensive drugs in elderly diabetic, hypertensive in-patients with or without impaired renal function in a tertiary care hospital." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 696. http://dx.doi.org/10.18203/2319-2003.ijbcp20181172.

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Background: Hypertension (HTN) and Diabetes mellitus (DM) are the leading contributors to the cardiovascular mortality and morbidity. Drug utilisation studies (DUS) are potential tools in the evaluation in health care systems. Objectives was to analyse the drug usage pattern of anti-hypertensives in elderly hypertensive diabetic in-patients in a tertiary hospital. To analyse drug usage pattern of anti-hypertensives in elderly hypertensive, diabetic in-patients with renal impairment in a tertiary hospital.Methods: The study population consisted of 165 hypertensive diabetic in-patients at Shri D

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Hijazi, Mohamad Ali, André Gessner, and Nahed El-Najjar. "Repurposing of Chronically Used Drugs in Cancer Therapy: A Chance to Grasp." Cancers 15, no. 12 (2023): 3199. http://dx.doi.org/10.3390/cancers15123199.

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Despite the advancement in drug discovery for cancer therapy, drug repurposing remains an exceptional opportunistic strategy. This approach offers many advantages (faster, safer, and cheaper drugs) typically needed to overcome increased challenges, i.e., side effects, resistance, and costs associated with cancer therapy. However, not all drug classes suit a patient’s condition or long-time use. For that, repurposing chronically used medications is more appealing. This review highlights the importance of repurposing anti-diabetic and anti-hypertensive drugs in the global fight against human mal

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Singla, Ritika, Harcharan Singh, Anita K. Gupta, and Vijay K. Sehgal. "A Study of Anti-hypertensive Drug Prescription Patterns in Hypertensive Post-menopausal women." International Journal of Medical and Dental Sciences 7, no. 1 (2018): 1594. http://dx.doi.org/10.18311/ijmds/2018/18907.

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<p><strong>Background:</strong> Drug prescription in menopause is complex as estrogen deficiency, hypertension (HT) and other risk factors, rapidly increase the risk of cardiovascular diseases (CVD) in post-menopausal women (PMW).</p><p><strong>Objectives:</strong> To evaluate the prescription trends of anti-hypertensive drugs in PMW.</p><p><strong>Methods:</strong> This was an observational, cross sectional study conducted over a period of 1 year, on hypertensive PMW. The prescriptions were evaluated for antihypertensive drug u

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Wang, Jiwu. "History of Development, Classification, Mechanism of Action and Rational Application of Major Anti-Hypertensive Drugs." International Journal of Public Health and Medical Research 1, no. 2 (2024): 44–52. http://dx.doi.org/10.62051/ijphmr.v1n2.07.

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With the rise of the aging population, the number of people with high blood pressure is increasing. Hypertension can cause cerebral hemorrhage, cerebral infarction, heart failure, coronary atherosclerotic heart disease and renal failure. One of the most common treatments for hypertension is drug therapy. Common anti-hypertensive drugs include angioplasty-converting enzyme inhibitors, calcium channel blockers, adrenergic receptor antagonists, diuretics, central anti-hypertensive drugs and vasodilation. The types of drugs used vary depending on the individual's condition. This article reviews th

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Nandita Kumari, Nandita Kumari. "Anti-Hypertensive Medication in Pregnancy." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 339–44. https://doi.org/10.35629/4494-1003339344.

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Maternal hypertensive condition enduring one of the main sources of gestationalconnected on one’s mother side and causing death rate and loss of life. A complete evaluation of the reaction of drugs against high blood pressure or for long term increase in blood pressure during gestational is require to make knowledgeable decisions in clinical practice and also for the practitioner. This systematized review aimed to evaluate the reaction of antihypertensive drugs in hypertension during gestational. Antihypertensive medicine is widely utilized in the treatment of hypertension in gestational in sp

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K. Deepak Maharshi, T. Vani, M. Navaneetha, G. Jyothi, Shantveer Halcher, and Gururaj V Wadageri. "Prescription pattern of anti-hypertensive drugs among hypertensive patients at district hospital." International Journal of Research in Hospital and Clinical Pharmacy 1, no. 2 (2019): 57–61. http://dx.doi.org/10.33974/ijrhcp.v1i2.86.

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Background: To conduct a prospective observational study on prescribing pattern of anti-hypertensive drug in the department of general medicine in Government District hospital, Gulbarga. In this study it was aimed to evaluate the current practice of anti-hypertensive drug by comparing with JNC-8 guidelines in population. Objectives: The objective of our study is to determine the prescription pattern of antihypertensive drugs and adherence to JNC8 guidelines and to find out the most prescribed anti-hypertensive drugs. Methods: A Prospective Observational Study of 06 months was conducted. Undert

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Rafanelli, Martina, Giuseppe Dario Testa, Giulia Rivasi, and Andrea Ungar. "Evaluation of Patients with Syncope in the Emergency Department: How to Adjust Pharmacological Therapy." Medicina 57, no. 6 (2021): 603. http://dx.doi.org/10.3390/medicina57060603.

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The rate of syncope in the Emergency Department ranges between 0.9 and 1.7%. Syncope is mostly related to a underlying reflex or orthostatic mechanism. A bradycardic or a hypotensive phenotype, may be identified. The latter is the most common and could be constitutional or drug induced. Consequently, obtaining an accurate drug history is an important step of the initial assessment of syncope. As anti-hypertensive medication might be responsible for orthostatic hypotension, managing hypertension in patients with syncope requires finding an ideal balance between hypotensive and cardiovascular ri

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Baker, Karen. "Drug Interactions: Anti-Hypertensive and Cardiac Medications." Journal of Oral and Maxillofacial Surgery 66, no. 8 (2008): 3. http://dx.doi.org/10.1016/j.joms.2008.05.015.

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9

., Shalini, and Manish Kumar Goel. "Non-Adherence to Anti-Hypertensive Treatment." Indian Journal of Community Health 32, no. 1 (2020): 126–29. http://dx.doi.org/10.47203/ijch.2020.v32i01.025.

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Background: In developed countries, adherence among patients suffering from chronic diseases averages only 50%; in developing countries it is assumed to be much lower. Aims & objectives: To find out the prevalence of non-adherence to antihypertensive treatment among individuals seeking anti-hypertensive treatment from tertiary care hospital in New Delhi & to find out the factors related to non-adherence to the anti-hypertensive treatment among study subjects. Material and Methods: A cross-sectional hospital-based study was conducted from June to October 2018 among 150 diagnosed cases o

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Samiyappan, Jagadeeswari, and Sarika Yadav. "A Cross-Sectional Study To Assess The Drug Adherence And Awareness Of Hypertension Among Hypertensive Stroke Patients In A Selected Hospital, Bangalore." Journal of Neonatal Surgery 14, no. 4 (2025): 214–19. https://doi.org/10.52783/jns.v14.2743.

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Introduction: Hypertension is the most prevalent modifiable risk factor for cardiovascular diseases and stroke. Among many factors, low adherence to anti-hypertensive drugs is the main contributing factor for poor control of blood pressure among hypertensive patients. The aim of this study is to assess the awareness on hypertension, level of adherence to anti-hypertensive medication and to assess the risk factors that led to stroke among the hypertensive patients in a selected hospital at Bangalore. Methods: A cross-sectional approach with consecutive sampling, 30 hypertensive patients with st

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Paudel, Gita, Sirisa Karki, Karma Murti Bhurtyal, and Lokeshwar Chaurasia. "Prescription pattern of anti-hypertensive drugs in Chitwan Medical College Hospital." Janaki Medical College Journal of Medical Science 9, no. 1 (2021): 41–46. http://dx.doi.org/10.3126/jmcjms.v9i1.38325.

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Background and Objectives: Hypertension is a crucial health issue globally. Cardiovascular and kidney disease is one of the results of hypertension which remarkably confer to overall mortality. Thus, the aim of this study is to investigate the prescribing pattern of anti-hypertensive drugs to hypertensive patients and also to establish the current trend of prescribing pattern of anti-hypertensive drugs at Chitwan Medical College (CMC). Material and Methods: A descriptive cross-sectional study was conducted among 290 patients to assess the prescribing pattern of anti-hypertensive drugs fr

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SAILENDRANATH, BISWAS, SAHA ANINDITA, KUMAR DAS ASISH, NAIR VINEET, and BISWAS DEBABRATA. "ANTI- HYPERTENSIVE DRUG INDUCED GINGIVAL ENLARGEMENT-A CASE REPORT." Journal of Disease and Global Health 10, no. 1 (2017): 7–11. https://doi.org/10.5281/zenodo.546194.

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<strong>Background:</strong> Drug induced gingival overgrowth refers to the abnormal growth of the gingival tissues secondary to the use of a systemic medication. Certain anticonvulsants, immunosuppressive drugs and a number of calcium channel blockers have been shown to produce similar gingival overgrowths in certain susceptible patients. Amlodipine is a comparatively new calcium channel blocker and is being used with increasing frequency in the management of hypertension and angina. Although amlodipine is considered as a safe drug, very rarely it may induce gingival overgrowth and hence it i

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Mathur, Rahul, Bhumika Tamrakar, Anita Anita, et al. "Design and evaluation of Mucoadhesive Buccal Tablets of an anti-hypertensive drug - Valsartan." International Journal of Research and Development in Pharmacy & Life Sciences 7, no. 5 (2018): 3110–14. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2018.7(5).3110-3114.

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14

Radhika, A. R. "Drug utilization study of antihypertensive drugs in a tertiary care hospital." International Journal of Basic & Clinical Pharmacology 7, no. 12 (2018): 2309. http://dx.doi.org/10.18203/2319-2003.ijbcp20184680.

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Background: Hypertension is a major common disease and effects a million of people worldwide. And is risk factor for other diseases like cardiovascular diseases, stroke etc. The aim of our study was undertaken to study the utilization pattern of anti hypertensive drugs at a tertiary care hospital. The guidelines for the treatment of hypertension are put forward by the Joint National Committee (JNC) on detection, evaluation and treatment of blood pressure. The Indian guidelines endorsed by the cardiology society of India, the hypertension society of India, and Indian college of physicians close

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15

Dahal, Prasanna, Laxman Maharjan, Bibek Dahal, and Kissan Gupta. "Assessment of Prescription Patterns in Hypertensive and Diabetic Patients Visiting Private Tertiary Care Hospital of Dharan Municipality, Nepal." Sunsari Technical College Journal 2, no. 1 (2016): 44–47. http://dx.doi.org/10.3126/stcj.v2i1.14798.

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This study was conducted to assess the drug prescribing trend of anti-hypertensive and hypoglycemic agents in hypertensive and diabetic patients in tertiary care private Hospital. The study was prospective, cross-sectional and observational study. A total of 100 prescriptions were recorded. 56% were males as compared to 44% females. The age group of the patients varied from 30 to 90 years with majority individual above 50 years of age. 59% patients were hypertensive; 26% patients were diabetic and 15% had both the diseases. For the treatment of HTN, both mono-therapy and combination therapy we

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Odimegwu, Joy I., Oluwakayode Ezekiel Olatunji, Tolulope F. Okanlawon, and Ishola Ismail. "Diuretic and Anti-Hypertensive Activity of Clerodendrum Chinense (OSBECK) MABB. Aqueous Extract in 8% Salt Diet-Induced Hypertensive Rats." Advancements in Journal of Urology and Nephrology 6, no. 1 (2024): 01–10. http://dx.doi.org/10.33140/ajun.06.01.03.

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Diuresis refers to an increase in the rate of urine flow and sodium excretion from the system via the urine. It is a necessary excretory process that may prove difficult for some disease systems e.g. enlarged prostates. Hypertension occurs as a result of systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg. It is one of the most common chronic diseases affecting more than a billion people worldwide. A high dietary sodium intake is one of the factors associated with the development of hypertension. Clerodendrum chinensis is used by local communities in

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17

Roy, Udoy Shankar, Nazibur Rahman Khandaker, Saleh Uddin, Murshidur Rahman Khan, and Nihar Ranjan Sarker. "Prescription Pattern In Hypertensive Patients In A Tertiary Care Teaching Hospital, Dhaka, Bangladesh." Journal of Shaheed Suhrawardy Medical College 8, no. 2 (2018): 39–43. http://dx.doi.org/10.3329/jssmc.v8i2.37241.

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Background: Irrational drug prescribing is a common practice globally; it results in increased morbidity, mortality & economic burden on society. Drug utilization studies are an important tool to promote rational prescribing.Aims & Objective: To study on drug prescribing pattern in hypertensive patients.Materials and Methods: A drug utilization study was conducted in hypertensive patients by the department of cardiology in OPD at Shaheed Suhrawardy Medical college hospital for 6 months. 645 prescriptions were evaluated for prescribing pattern by using WHO drug use indicators.Results: 6

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18

Flack, J. M., S. V. Novikov, and C. M. Ferrario. "Benefits of adherence to anti-hypertensive drug therapy." European Heart Journal 17, suppl A (1996): 16–20. http://dx.doi.org/10.1093/eurheartj/17.suppl_a.16.

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19

Rivasi, Giulia, Martina Rafanelli, Enrico Mossello, Michele Brignole, and Andrea Ungar. "Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications." Drugs & Aging 37, no. 10 (2020): 725–38. http://dx.doi.org/10.1007/s40266-020-00796-5.

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20

Kathwate, Gunderao Hanumantrao, and S. Mohan Karuppayil. "Antifungal properties of the anti-hypertensive drug: Aliskiren." Archives of Oral Biology 58, no. 9 (2013): 1109–15. http://dx.doi.org/10.1016/j.archoralbio.2013.02.006.

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21

Goon, Patrick, Paul Stonelake, and Gregory Lip. "Hypertension, Anti-Hypertensive Therapy and Neoplasia." Current Pharmaceutical Design 13, no. 25 (2007): 2539–44. http://dx.doi.org/10.2174/138161207781663073.

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22

Udem, Ngozi Dorathy. "Drug Utilization Pattern of Antihypertensives in a Private Healthcare Setting in Enugu, Nigeria." TEXILA INTERNATIONAL JOURNAL OF PUBLIC HEALTH 10, no. 1 (2022): 94–99. http://dx.doi.org/10.21522/tijph.2013.10.01.art008.

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Hypertension is a public health challenge worldwide. Drug utilization study is a component of medical audit that monitors and evaluates prescribing practices and recommends necessary modifications. This study focused on the drug utilization pattern of antihypertensive drugs. The study was a retrospective study of facility records on drug use among hypertensive patients. It was conducted in a private health care setting facility in Enugu. A total of 1,005 prescriptions were evaluated for drug prescribing patterns. The blood pressure control was evaluated. A combination of two drugs was frequent

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Nabi, Golam, Paritosh Kumar Boral, Debeshis Mohanta, Farah Tasneem Mou, and SM Rokonuzzaman. "Non Compliance Pattern of Anti Hypertensive Treatment." Journal of Dhaka Medical College 24, no. 2 (2016): 108–16. http://dx.doi.org/10.3329/jdmc.v24i2.29620.

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A cross-sectional type of observational study was conducted on hypertensive patients attending at medicine department (OPD and admitted) of Z. H. Sikder Womens Medical College Hospital, Dhaka, from January to June 2014, to see the patient compliance of anti-hypertensive drugs. The sample size was 185. Patients with evidence of hypertension as per Seventh Joint National Committee Criteria (defined as systolic blood pressure >140 mm oh Hg or diastolic blood pressure >90 mm of Hg or use any anti-hypertensive medication, regardless of blood pressure. Time from initiation of antihypertensiv

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E.I., Okoye, and Usiakpebru A.E. "Analysis of Antibiotics (Amoxicillin) and Anti-Hypertensive (Nifedipine) Drugs." Pharmaceutical and Chemical Journal 5, no. 1 (2018): 24–30. https://doi.org/10.5281/zenodo.13890262.

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This work analyzed ten capsules of amocycillin 500 mg each from drug resolving stores (shop 1), Opaclsas Pharmacy (shop 2), Happy Home Pharmacy (shop 3), Cheff Pharmacy Ltd (shop 4) Chimezie Medicine Stores (shop 5). The anti-hypertensive drugs (Nifedipine, 20 mg) were obtained from drug resolving stores (shop 1), Happy Home Pharmacy (shop 2), Cheff Pharmacy (shop 3), Chimezie Medicine stores (shop 4) and D-Global Pharmacy (shop 5). All capsules and tablets were obtained from different locations in Asaba. The analysis carried out on them are disintegration time, percentage uniformity of weight

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Vaijayanthi, S. Parimala, and N. Mathiyalagan. "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide." International Letters of Chemistry, Physics and Astronomy 26 (January 2014): 1–8. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.26.1.

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

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Vaijayanthi, S. Parimala, and N. Mathiyalagan. "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide." International Letters of Chemistry, Physics and Astronomy 26 (January 24, 2014): 1–8. http://dx.doi.org/10.56431/p-2swj0a.

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

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Gunawan, Gunawan, Suhardjo Sitam, and Lusi Epsilawati. "Densitas tulang mandibula pengguna obat anti hipertensi calcium channel blocker (CCB) melalui radiograf panoramik." Jurnal Radiologi Dentomaksilofasial Indonesia 4, no. 2 (2020): 1. http://dx.doi.org/10.32793/jrdi.v4i2.527.

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Objectives: The purpose of this research was to describe radiographic density of mandibular bone in calcium channel blocker anti-hypertensive drug users. Bone density in the mandible is assessed from the trabecular. Panoramic radiograph is a routine examination that is often done in dentistry that can be used to assess changes in quality in the form of changes in bone density in users of anti-hypertensive calcium channel blockers  Material and Methods: This research is a descriptive study of 21 panoramic radiographs of calcium channel blocker anti-hypertensive drug users aged 40-75 years

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Kumar, Kukkadapu Pavan, Katta Sunand, Nerella Mounika, Mohammed Abdul Samad, A. Madhu Babu, and Krishna Mohan Chinnala. "Formulation, Development, and Optimization of Anti- Hypertensive Nisoldipine Extended-Release Tablet Formulation." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 5, no. 03 (2020): 37–44. http://dx.doi.org/10.21477/ijapsr.5.3.1.

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A drug molecule has to be water-soluble to be readily delivered to the cellular membrane. Many drugs are waterinsoluble, which creates numerous problems in the development of dosage forms. Controlled drug delivery formulation releases the drug with controlled kinetics for days and months, reducing the frequency of dosing, minimizing side effects, and improving patient compliance. Nisoldipine is a calcium channel antagonist that is indicated for the treatment of hypertension with very poor aqueous solubility. Thus, there is a need to improve the rate of drug release. Hence, the study was carrie

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Biswas Majee, Sutapa, Souvik Gupti, Trisha Mishra, and Rachayeeta Bera. "In vitro, ex vivo and in vivo studies on anti-hypertensive-loaded transdermal and buccal patches." Journal of Drug Delivery and Therapeutics 15, no. 3 (2025): 142–50. https://doi.org/10.22270/jddt.v15i3.7044.

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The occurrence of hypertension is increasing slowly among urban and rural segments of the Indian population, irrespective of gender. It can affect quality of life and also lead to mortality under serious circumstances. Although several oral anti-hypertensive medications are available in the Indian market, the management of hypertension is reported to be poor. Anti-hypertensive–based transdermal or buccal patches may be necessary for patients where oral or parental route of administration is not possible or when no better control is achievable. Apart from Catapres®TTS, no other transdermal or b

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Nikita, Sonawane* Ritik Ahire Mayur Chavan Vinod Chaure Ravindra Patil. "Analytical Methods Review on Anti-Hypertensive Drug: CANDESARTAN (CAND)." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1994–2005. https://doi.org/10.5281/zenodo.14927417.

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Hypertension is a serious condition that significantly increases the chances of developing heart failure, stroke, and kidney problems. For managing stage 2 hypertension, experts from the Joint National Committee recommend using a combination of two drugs. This approach helps in effectively controlling blood pressure, reducing the number of pills patients need to take, and improving their overall adherence to treatment, which ultimately lowers the risk of complications. One effective option is candesartan cilexetil, an angiotensin II receptor blocker (ARB) that works as a prodrug with 40% bioav

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Ahluwalia, Pritpal Singh, Mirza Shiraz Baig, and Meenakshi Bhattacharya. "Drug utilization study of anti-hypertensive drugs at a tertiary care hospital." International Journal of Basic & Clinical Pharmacology 9, no. 8 (2020): 1241. http://dx.doi.org/10.18203/2319-2003.ijbcp20203142.

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Background: The increasing prevalence of hypertension influence the prescribing patterns of antihypertensive drug. Prescribing against evidence-based guidelines in hypertension treatment leads to the increase cost of medications and problems in providing affordable prescriptions to population. The aim of present study was to analyse anti-hypertensive prescribing pattern in Government Medical College and Hospital, Aurangabad, Maharashtra, India.Methods: Study was prospective, observational, open label and descriptive clinical study. It included 336 patients admitted in MICU during January 2018

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Shinde, Supriya, Vishal Yadav, Prakash Jadhav, and Apoorva Jadhav. "Formulation and evaluation of microemulsion containing anti-hypertensive drug." RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 13, no. 12 (2020): 5726–32. http://dx.doi.org/10.5958/0974-360x.2020.00997.x.

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Vivekanandan, K., N. Harikrishnan, E. Bhavya, P. Babu, and S. Nandhakumar. "Formulation and Evaluation of Floating Drug Delivery of an Anti-Hypertensive Drug." Research Journal of Pharmacy and Technology 11, no. 11 (2018): 4785. http://dx.doi.org/10.5958/0974-360x.2018.00871.5.

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Bhadoriya, Sandeep Singh, and Prashant Wadagbalkar. "Pharmaco-ecomonic study of oral anti-hypertensive drugs available in Indian pharmaceutical market." International Journal of Basic & Clinical Pharmacology 12, no. 4 (2023): 574–78. http://dx.doi.org/10.18203/2319-2003.ijbcp20231894.

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Background: Hypertension is a global public health problem. To decrease its morbidity and mortality it needs life-long treatment. There is a wide range of variation in the prices of antihypertensive drugs marketed in India. Thus, a study was planned to evaluate the difference in cost of different brands of same active drug by calculating percentage variation of cost. Methods: The cost of different brands of commonly used anti-hypertensive drugs was sorted out by referring latest CIMS, MIMS and drug today. The cost of 10 dosage forms (tablets/capsules) in INR of each brand, cost ratio and perce

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Madoro, Derebe. "Anti-Hypertensive Medication Adherence and Associated Factors among Adult Hypertensive Patients at Dilla University Referral Hospital, South Ethiopia." Public Health Open Access 8, no. 1 (2024): 1–12. http://dx.doi.org/10.23880/phoa-16000267.

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Background: Hypertension is a global public health challenge that contributes to the burden of hypertensive heart disease, stroke, renal failure, premature morbidity, and mortality. The availability of effective antihypertensive medications didn’t bring expected outcomes in terms of adherence for antihypertensive medication. Objective: The aim of this study was to assess antihypertensive medication adherence and associated factors among adult hypertensive patients at Dilla university referral hospital, Southern Ethiopia, 2021. Methods: A hospital-based cross-sectional study was conducted, at D

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Khan, GM, RK Thapa, A. Khakurel, et al. "Patient Demographics and Drug Prescription Pattern among Hypertensive Patients of Pokhara Valley." Journal of Chitwan Medical College 3, no. 2 (2013): 32–35. http://dx.doi.org/10.3126/jcmc.v3i2.8440.

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Hypertension is a common disease of the present world. Patient characteristics and use of anti-hypertensive agents directly affect the development and control of hypertension respectively. So, the objective of this study was to determine the patient demographics and drug prescription pattern among hypertensive patients of Pokhara valley. A community based descriptive cross-sectional study was conducted in different places of Pokhara valley. Performa was used for the collection of data and analysis was done using MS-excel and SPSS (version 17.0). The study showed that majority of the hypertensi

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Larsen, Ann D., Reiner Rugulies, Johnni Hansen, et al. "Night work and risk of ischaemic heart disease and anti-hypertensive drug use: a cohort study of 145 861 Danish employees." European Journal of Public Health 30, no. 2 (2019): 259–64. http://dx.doi.org/10.1093/eurpub/ckz189.

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Abstract Background Ischaemic heart disease (IHD) and hypertension are leading causes of mortality and night work has been suspected as a risk factor. Meta-analyses and previous studies are often limited by power and various definitions of exposure and outcomes. This study aimed to investigate if night work increases the risk of IHD or anti-hypertensive drug usage in a large cohort of Danish employees. Methods Individual participant data on night work were drawn from the Danish Labour Force Survey (1999–2013). We included 145 861 participants (53% men) 21–59 years of age working 32 h or more p

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Pal, Pawan Chandrashekhar* Mrityunjay Kumar Yasir Akhbar Dar Faizan Jeelani Shergojri Nauneet Kumar Satyam Gulwani. "Preparation And Characterization of Microencapsulating Drug Delivery Systems of Few Anti-Hypertensive Drugs." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3614–19. https://doi.org/10.5281/zenodo.15480350.

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The present study focuses on the preparation and characterization of microencapsulated drug delivery systems for selected antihypertensive agents. Microencapsulation is an advanced drug delivery approach that enhances the pharmacokinetic profile, stability, and controlled release of therapeutic agents. In this project, various antihypertensive drugs—such as amlodipine, atenolol, and enalapril cellulose and sodium alginate via techniques such as solvent evaporation and ionic gelation. The goal of developing microencapsulating drug delivery systems (DDS) for antihypertensive treatments is

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Rajak, Devraj, Deepali Sahu, Anushree Jain, et al. "Review on Toxicity of Antihypertensive Drugs." Asian Journal of Dental and Health Sciences 2, no. 4 (2022): 64–68. http://dx.doi.org/10.22270/ajdhs.v2i4.28.

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Adverse drug reactions are common and pose a serious health problem, limiting treatment options, causing compliance issues, and even leading to therapy discontinuation. Hypertension is a chronic disease that is regarded as a major risk factor for cardiovascular disease. To achieve a target blood pressure in an individual patient, a wide range of anti-hypertensive agents are available as single or combination therapy, whereas combination therapy increases the risk of developing Adverse Drug Reaction. Hypertensive patients frequently have coexisting disease conditions such as hyperlipidemia, imp

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Marin, Gustavo H., Lupe Marin, Daniel Agüero, Mariana Pagnotta, Gina Marin, and Luis Blanco. "Budgetary Impact of Covering “Me-Too” Drugs from Social Security: Buenos Aires State Case Report." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 234–38. http://dx.doi.org/10.22270/jddt.v10i3-s.4087.

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The majority of new drugs that are register at Health Global Market are not considered real innovations and due to their chemical structure similarity of reference’s group drug, they are known as “me-too”. These “me too” drugs has no additional therapeutic benefits but greatly increasing treatment´s. PURPOSE: To demonstrate the economic impact in Social Security budget by covering “me too” medicines. METHODS: An epidemiological-descriptive-analytical study was performed in order to analyze the burden of anti-hypertensive prescription from patients under coverage by Buenos Aires State Social Se

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Sonal, Kumbhar1* Nilesh Chougule2 Ayan Sayyad3. "Adverse Drug Reactions to Anti-hypertensive: A Hospital Survey Pharmacovigilance." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 240–47. https://doi.org/10.5281/zenodo.12657664.

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Antihypertensive medications are critical in managing hypertension, a prevalent and potentially life-threatening condition. However, the benefits of these medications can be offset by adverse drug reactions (ADRs), which can significantly affect patient compliance, quality of life, and overall treatment outcomes. This study aims to investigate the incidence, types, and severity of ADRs associated with antihypertensive drugs in a hospital setting, contributing to pharmacovigilance efforts and enhancing patient safety. The survey was conducted on 108 patients. Their mean age is 55.14 years, and

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Omar, Rebaz, Pelin Koparir, and Metin Koparir. "SYNTHESIS OF 1,3-THIAZOLE DERIVATIVES." INDIAN DRUGS 58, no. 01 (2021): 7–19. http://dx.doi.org/10.53879/id.58.01.12427.

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Many heterocyclic compounds containing nitrogen atom are used in drug development. Thiazole is one of the most important heterocyclic compounds in drug design, which contains sulfur and nitrogen atom. Different site reactions in thiazole compounds extend to new drug synthesis and plays an important role in medicinal chemistry. Thiazole and derivatives are found to possess widely biological activities such as anti-inflammatory, anti-diabetic, anti-microbial, anti-cancer, anti-consulsant, anti-HIV, anti-hypertensive, anti-Alzheimer, anti-oxidant and anthelmintic. The aim of this review is to cor

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Adahalli, Sachin Basavaraj, and Manjula Talluri. "FORMULATION AND EVALUATION OF TABLET PREPARED BY COAMORPHOUS SYSTEM CONTAINING ANTI-HYPERTENSIVE AND ANTI-HYPERLIPIDEMIC DRUG." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 182. http://dx.doi.org/10.22159/ijpps.2016.v8i9.12895.

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<p><strong>Objective: </strong>Amlodipine besylate (AML) and Atorvastatin calcium (ATR) belong to biopharmaceutical classification system (BCS) class II (i.e. low solubility and high permeability) which leads to variable bioavailability. Hence, the aim of this study was to enhance the solubility of both drugs by utilizing the co-amorphous technique. This converted form and physical mixture of both drugs were utilized in the formulation of tablets.</p><p><strong>Methods: </strong>The co-amorphous system was prepared by using rotary flash evaporator. Sol

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Gandhi, Kunjan, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Uncoated Bilayer Tablet of Anti-Hypertensive Agents." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 100–107. http://dx.doi.org/10.22270/jddt.v10i4-s.4229.

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The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension.The objective of this study to compare the specific characteristics of Metoprolol [beta selective (cardio selective) adrenoreceptor blocking agent] and Hydrochlorothiazide (Thiazide Diuretics]) in order to design stable formulation. It can be concluded that bilayer tablet were successfully formulated to achieve immediate release of Hydrochlorothiazide (HCTZ) and tailored release of Metoprolol (MPL)by using Dual Release Drug Absorption System(DUREDAS technology).

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Thomas, T. J., J. R. Seibold, L. E. Adams, and E. V. Hess. "Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients." Biochemical Journal 294, no. 2 (1993): 419–25. http://dx.doi.org/10.1042/bj2940419.

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We studied the effect of hydralazine, an antihypertensive drug with lupus-inducing side effects, on the conformation of poly(dG-m5dC).poly(dG-m5dC) and a plasmid with a 23 bp insert of (dG-dC)n.(dG-dC)n sequences. Using an e.l.i.s.a. with a monoclonal anti-(Z-DNA) antibody Z22, we found that hydralazine provoked the Z-DNA conformation in poly(dG-m5dC).poly(dG-m5dC) at 250-500 microM concentration. The supercoiled form of hydralazine-treated plasmid bound to Z22 in a gel-retardation assay. To examine further whether Z-DNA could act as an inciting agent in anti-nuclear antibody production in pat

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Martínez-Villaluenga, Cristina, Elena Peñas, Daniel Rico, et al. "Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies." Marine Drugs 16, no. 12 (2018): 512. http://dx.doi.org/10.3390/md16120512.

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Metabolic syndrome (MetS) greatly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The aim of this study was to evaluate the efficacy of functional snacks containing a combination of wakame (W) and carob pod (CP) flours in reducing markers associated with MetS. The mechanisms of action underlying these effects were also evaluated. In vitro approaches were carried out in mature 3T3-L1 adipocytes and RAW 264.7 macrophages treated with different doses of extracts from W, CP, or a combination of both. Furthermore, an in vivo experiment was conducted in rats with MetS tre

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Siska, Siska, Endang Hanani, Tahyatul Bariroh, et al. "Effect of the ethanol extract of Pereskia bleo (Kunth) DC. on the blood pressure and electrolyte levels of hypertensive rats." Journal of Herbmed Pharmacology 12, no. 3 (2023): 448–52. http://dx.doi.org/10.34172/jhp.2023.50.

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Introduction: The green cactus Pereskia bleo is thought to have anti-cancer, anti-tumor, anti-inflammatory, and anti-rheumatic properties. Additionally, it treats hypertension and diabetes; However, no scientific evaluation of its antihypertensive activity has been conducted. The purpose of this study was to investigate the effects of oral administration of P. bleo extract (PBE) on male rats’ blood pressure, urine volume, and sodium and potassium levels. Methods: Sodium chloride (NaCl) solution (4%) was administered orally to induce hypertension. A non-invasive tail method was used to measure

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Misal, A. R.* Maske Vaishnavi S. Pare Rutuja U. Kharat Anjali S. "Anti- Hypertensive Activity Of Ginger, Cardamom, Garlic." International Journal of Pharmaceutical Sciences 2, no. 3 (2024): 613–27. https://doi.org/10.5281/zenodo.10835119.

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Blood pressure is caused by another medical condition or use of certain medicine. It usually gets better after you treat that condition or stop taking medicines that are causing it Antihypertensive drug therapy has been remarkable improved in the last 60 years received different classes of drugs have received prominence with passage of time in this period. Before 1950 hardly any effective and toleratad antihypertensive was available .There is majer risk factors of hypertension are High sodium (salt)" overweight & obesity physical inactivity According to world health organisation Imperical

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Moulik, P. K., and K. J. Hardy. "Hypertension, anti-hypertensive drug therapy and erectile dysfunction in diabetes." Diabetic Medicine 20, no. 4 (2003): 290–93. http://dx.doi.org/10.1046/j.1464-5491.2003.00911.x.

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BLACK, H. "Individualized Selection of Anti-hypertensive Drug Therapy for Older Patients." American Journal of Hypertension 9, no. 4 (1996): 197A. http://dx.doi.org/10.1016/0895-7061(96)82158-3.

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