Academic literature on the topic 'Anti-idiotype'

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Journal articles on the topic "Anti-idiotype"

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Tzioufas, Athanasios G., and John G. Routsias. "Idiotype, anti-idiotype network of autoantibodies." Autoimmunity Reviews 9, no. 9 (2010): 631–33. http://dx.doi.org/10.1016/j.autrev.2010.05.013.

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McCarthy, Helen, Christian H. Ottensmeier, Terry J. Hamblin, and Freda K. Stevenson. "Anti-idiotype vaccines." British Journal of Haematology 123, no. 5 (2003): 770–81. http://dx.doi.org/10.1046/j.1365-2141.2003.04698.x.

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THANAVALA, Y. "Anti-idiotype vaccines." Trends in Biotechnology 7, no. 3 (1989): 62–66. http://dx.doi.org/10.1016/0167-7799(89)90065-6.

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Hsu, Kuo‐Hui, and Fun S. Chu. "Anti‐idiotype and anti‐anti‐idiotype antibodies for aflatoxin from laying hens." Food and Agricultural Immunology 7, no. 2 (1995): 163–74. http://dx.doi.org/10.1080/09540109509354875.

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Iwasaki, Yoshiaki, Hiroyuki Takabatake, Toshiyuki Shinji, Marc Monestier, and Soldano Ferrone. "Structural profile of idiotype, anti-idiotype and anti-anti-idiotype monoclonal antibodies in the HLA-DQ3 antigenic system." European Journal of Immunology 24, no. 11 (1994): 2874–81. http://dx.doi.org/10.1002/eji.1830241144.

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TAUSSIG, M. J., D. KIRK, M. W. WANG, et al. "Idiotype-Anti-Idiotype Interactions of VHIX-Coded Anti-Progesterone and Anti-Arsonate Antibodies." Scandinavian Journal of Immunology 26, no. 3 (1987): 267–76. http://dx.doi.org/10.1111/j.1365-3083.1987.tb02260.x.

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Langone, John J., and Robert J. Bjercke. "Idiotype-anti-idiotype hapten immunoassays: Assay for cotinine." Analytical Biochemistry 182, no. 1 (1989): 187–92. http://dx.doi.org/10.1016/0003-2697(89)90740-9.

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Tankersley, Donald L., M. Sue Preston, and J. S. Finlayson. "Immunoglobulin G dimer: An idiotype-anti-idiotype complex." Molecular Immunology 25, no. 1 (1988): 41–48. http://dx.doi.org/10.1016/0161-5890(88)90088-0.

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Chu, Fun S., Xuan Huang, and Chris M. Maragos. "Production and characterization of anti-idiotype and anti-anti-idiotype antibodies against fumonisin B1." Journal of Agricultural and Food Chemistry 43, no. 1 (1995): 261–67. http://dx.doi.org/10.1021/jf00049a046.

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Hsu, Kuo‐Hui, and Fun S. Chu. "Anti‐idiotype and anti‐anti‐idiotype antibodies generated from polyclonal antibodies against aflatoxin b1." Food and Agricultural Immunology 7, no. 2 (1995): 139–51. http://dx.doi.org/10.1080/09540109509354873.

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Dissertations / Theses on the topic "Anti-idiotype"

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Lefèvre, Gilbert. "Anticorps anti-idiotype et hormone anti-mullerienne." Paris 7, 1989. http://www.theses.fr/1989PA077083.

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Des anticorps anti-idiotype polyclonaux ont ete prepares contre trois anticorps monoclonaux diriges contre l'hormone anti-mullerienne bovine. Tous les anticorps anti-idiotypes inhibent la fixation d'hormone anti-mullerienne marquee sur l'anticorps monoclonal contre lequel ils ont ete prepares
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Elliott, T. J. "Interaction of anti-idiotype antibodies with the surface of neoplastic lymphocytes." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373970.

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Macbeth, F. R. "Diagnostic and therapeutic uses of anti-idiotype antibody in the management of human B-cell lymphoma." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375173.

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ZAGHOUANI, HABIB. "Induction chez la souris d'une reponse contre le dextrane b1355s par sensibilisation avec des anticorps anti-idiotypiques." Paris 7, 1987. http://www.theses.fr/1987PA077019.

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Chang, Shang-Hung. "Generation and testing of an anti-idiotype that acts as a surrogate antigen for oxidized LDL (OxLDL) in serological studies measuring anti-OxLDL antibodies." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/11743.

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Atherosclerosis is thought to be mediated by immune response in which oxidized low density lipoprotein (OxLDL) is one of the major antigens. The exact linkage between anti-OxLDL antibodies and atherosclerosis, however, is controversial. One of the sources of this controversy is the inherently heterogeneous and complex nature of OxLDL as an antigen. This study aims to identify and characterise a new type of structurally definable surrogate antigen for OxLDL for use in serologic assays. The study applied two techniques for cloning antibodies. The first step was the generation of a monoclonal anti-OxLDL antibody, designated LO-1, by fusing mouse B cells and myeloma cells. The mouse used in this fusion was not immunized but fed with high fat diet to reflect the physiologic but hyperlipidemic immune environment. The second step was to use a phage display system (Tomlinson library of single chain variable antibody fragments) to screen anti-idiotypic antibodies (anti-id) against an anti-OxLDL monoclonal antibody generated from that mouse. The anti-id selected for further characterisation, was designated H3. This anti-id, which probably mimics both peptide and lipid components of OxLDL, was used as an antigen in a serologic assay (both in mice and humans) and compared with ordinary OxLDL antigens conventionally used by earlier researchers. Titres of antibodies against H3 correlated well with antibodies against malondialdehyde-conjugated LDL. Although the overall performance of anti-H3 antibodies was no better than conventional anti-OxLDL assays in predicting atherosclerosis, they showed an inverse relationship with the extent of left anterior descending coronary artery stenosis in patients with established coronary artery disease. This project has developed a novel approach to measuring OxLDL antibodies. The proposed unique mimicry of both the lipoprotein and the phospholipid components of OxLDL may reveal a functionally significant epitope of OxLDL that has not been successfully mapped by previously reported methodologies. The novel anti-id H3 and the corresponding mimetic region of OxLDL therefore provide new insight and new tools for future research on the humoral response related to atherosclerosis.
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Solassol, Isabelle. "Analyse de deux antigènes associés aux tumeurs solides, l'antigène carcinoembryonnaire (ACE) et l'antigène erbB-2 : étude des épitopes continus de l'ACE : production de fragments scFv humains anti-idiotypes anti-erbB-2 en vue de la mise au point d'un vaccin anti-tumoral." Montpellier 1, 2000. http://www.theses.fr/2000MON1T023.

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JOLIMOY, CYRILLE. "Sensibilisation de la recherche des anticorps anti-idiotypes par absorption des anticorps anti-hla de classe i sur plaquettes : mise au point des cross-matches par cytometrie en flux." Dijon, 1994. http://www.theses.fr/1994DIJOM088.

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Holm, Patrik. "Single-chain antibody construction and functional mapping of the monoclonal antibody TS1 : Its interaction with the antigen and the anti-idiotype." Licentiate thesis, Karlstad University, Division for Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-2323.

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<p>The aims of this study are to synthesize and produce a single-chain antibody (scFv) of the anti-cytokeratin 8 monoclonal IgG antibody TS1 and to functionally map amino acid residues important for the interaction with its antigen and the anti-idiotypic antibody TS1. The TS1 antibody has been shown to be effective in binding cytokeratin 8 (CK8) expressed in tumors in vivo and is proposed to be useful in immunotargeting and/or immunotherapy. The anti-idiotypic antibody TS1 can be used to regulate the tumor:non-tumor ratio. Mutagenesis of certain amino acid residues can be used to alter the affinity to improve the tumor:non-tumor ratio further.</p><p>In the present study, the TS1 IgG was chemically modified to specify groups of residues important for interaction with both CK8 and TS1. If important residues were found in the CDRs, they were mutated in the TS1 scFv construct and the effect was studied using ELISA.</p><p>The main conclusions drawn from this study are that the important amino acid residues in TS1 for the interaction with both CK8 and TS1 are mainly tyrosines, charged residues and a tryptophan. A central interacting interface was identified with the somewhat unusual participation of residues in the CDR 2 of the light chain. Mutations which resulted in increased affinity to both CK8 and TS1 were also identified.</p>
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Holm, Patrik. "Functional mapping and in vivo metabolism of the monoclonal antibody TS1 and its single-chain fragment : Its interaction with the antigen and the anti-idiotype." Doctoral thesis, Karlstad University, Faculty of Technology and Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-727.

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<p>Antibodies are proteins capable of specific interactions to a wide range of molecules. These interactions are facilitated by the complementary determining regions (CDR).</p><p>Carcinomas are the most common of human cancers and they release significant amount of cytokeratins (CK) in the necrotic areas of the tumors. The CKs stay in the tumor, since they have low solubility. The antibody studied in this thesis, the anti-CK 8 antibody TS1, has shown to be effective in tumor targeting and is proposed to be useful in therapy.</p><p>Single-chain antibodies (scFv) are recombinant antibodies which are much smaller than the intact IgG. This is an advantage when used in tumor therapy, since they can penetrate the tumors more easily than the larger IgG. Moreover, they are expressed by one single gene which make them easy to modify, for example by site-directed mutagenesis.</p><p>The anti-idiotypic antibody αTS1 can be used to clear the TS1 form the circulation and thereby clear the body from non-tumor bound TS1 in therapy. To be able to modify the binding of an antibody to its antigen and or anti-idiotype, these interactions must be studied. In this study this is accomplished by chemical modifications of the IgGs TS1 and αTS1 and the antigen CK 8. Guided by these results, amino acid residues were mutated by using site-directed mutagenesis in the TS1-218 scFv and the effects were studied. From mutational study results, the functional epitope could be mapped and it was found that there are mainly tyrosines, but also charged residues, serine and a tryptophan that are important for both interactions. The binding of TS1-218 to both αTS1 and CK 8 could be improved by changing the negatively charged side-chains by mutations to their corresponding amide or alanine.</p><p>Both the IgG and scFv versions of TS1 were administered in vivo. The IgG αTS1 was used to clear the TS1 from the circulation by forming immune complexes. The immune complexes, consisting of four or more antibodies, were mainly metabolized by the liver. The scFv TS1-218 could localize to the tumor in a tumor xenograft mouse model, although a higher uptake would be desired in a therapeutic strategy. The scFv was cleared rapidly by the kidneys, but the clearance could be slowed by pre-formed immune complexes with anti-TS1 scFv in vitro, prior to administration in vivo.</p>
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Furtado, Patricia Brotto. "Production and Characterisation of a chimaeric human IgE antibody, recognising der P 1, and its chimaeric human IgG1 anti-idiotype : the prospect of idiotypic-anti-idiotypic interactions as an intervention strategy for allergy." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368255.

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Books on the topic "Anti-idiotype"

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Congress on Idiotype Networks in Biology and Medicine (1989 Gennep, Netherlands). Idiotype networks in biology and medicine: Proceedings of the Congress on Idiotype Networks in Biology and Medicine, 17-20 April 1989, held in Gennep, the Netherlands. Edited by Osterhaus Albert, UytdeHaag Fons, and Commission of the European Communities. Directorate-General for Science, Research, and Development. Excerpta Medica, 1990.

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Albert, Osterhaus, and UytdeHaag Fons, eds. Idiotype networks in biology and medicine: Proceedings of the Congress on Idiotype Networks in Medicine and Biology, 17-20 April 1989, held in Gennep, the Netherlands. Excerpta Medica, 1990.

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Gomez, Daniel, Ana María Vázquez, Daniel F. Alonso, and Amparo Macías, eds. Anti-idiotype antibodies in cancer treatment. Frontiers Media SA, 2013. http://dx.doi.org/10.3389/978-2-88919-118-5.

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Cazenave, P. A. Progress in Vaccinology 3: Anti-Idiotypic Vaccines (Progress in Vaccinology). Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1991.

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Idiotype Networks in Biology and Medicine (International congress series). Elsevier, 1990.

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Book chapters on the topic "Anti-idiotype"

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Timmerman, John M. "Anti-Idiotype Antibodies." In Cancer Therapeutic Targets. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_51.

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Chatterjee, Sunil K., Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon. "Anti-Idiotype Vaccines." In Handbook of Cancer Vaccines. Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-680-5_12.

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Timmerman, John M. "Anti-Idiotype Antibodies." In Cancer Therapeutic Targets. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6613-0_51-2.

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Bhattacharya-Chatterjee, Malaya, and Heinz Kohler. "Anti-Idiotype Tumor Vaccines." In Immunobiology of Proteins and Peptides V. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2046-4_9.

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Koprowski, Hilary, and Dorothee Herlyn. "Anti-idiotype Vaccines Against Viral Infections." In Concepts in Viral Pathogenesis II. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4958-0_48.

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Bona, Constantin A. "Functional Heterogeneity of Anti-Idiotype Antibodies." In Anti-Idiotypes, Receptors, and Molecular Mimicry. Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3734-1_2.

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Siskind, Gregory W., Edmond A. Goidl, Young Tai Kim, Marc E. Weksler, and G. Jeanette Thorbecke. "Anti-Hapten Idiotype Models in Studies of Aging and Idiotype Networks." In Antibodies. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1873-6_10.

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Kennedy, Ronald C., and Gordon R. Dreesman. "Antigen Mimicry by Anti-Idiotype Antibodies That Recognize a Common Anti-Hepatitis B Surface Antigen Idiotype." In Advances in Experimental Medicine and Biology. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-7974-4_9.

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Bhattacharya-Chatterjee, Malaya, and Kenneth A. Foon. "Anti-idiotype antibody vaccine therapies of cancer." In Cancer Treatment and Research. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-6189-7_4.

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Cheung, Nai-Kong V. "Anti-Idiotype Immunotherapy Strategies for Brain Tumors." In Brain Tumor Immunotherapy. Humana Press, 2001. http://dx.doi.org/10.1007/978-1-59259-035-3_9.

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Conference papers on the topic "Anti-idiotype"

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Moffat, E. H., R. H. Furlong, A. L. Bloom, and J. C. Giddings. "A MURINE MODEL FOR FACTOR VIII ANTIBODY ANTI-IDIOTYPE REAGENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644030.

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The regulation of factor VIII antibody (FVIIIAb) production in haemophilic and non-haemophilic patients may be effected by anti-idiotype (Aid) antibodies which specifically react with FVIIIAb. Aid antibodies (reagents) were prepared from rabbits immunised with murine monoclonal FVIIIAb. Immuno fluorescent microscopy and cell culture studies were performed using murine hybridoma cells which secreted the FVIIIAbs.Immuno fluorescence studies examined the ability of the Aid reagents to bind to acetone fixed FVIIIAb secreting hybridoma cells. Positive surface membrane and intra-cytoplasmic staining patterns were seen with the Aid reagent when incubated with the corresponding murine hybridoma cell line. This reaction was blocked subsequent to the addition of the corresponding monoclonal FVIIIAb but was preserved when unrelated monoclonal FVIIIAb was incubated with the hybridoma cells. No fluorescence was observed when Aid reagent was incubated with unrelated FVIIIAb secreting hybridoma cultures.Following the addition of Aid reagent to FVIIIAb secreting hybridoma cultures and incubation for 19 hours, the resultant hybridoma supernatants were examined for FVIIIAb content using an immunoradiometric technique. The Aid reagent failed to inhibit FVIIIAb secretion by hybridoma cells. Thus, although Aid reagents were capable of binding to fixed FVIIIAb secreting cells, they failed to inhibit FVIIIAb secretion from hybridoma cultures. The conjugation of Aid reagent with immunotoxin may however have cytotoxic potential. The murine model provides a method for the study of Aid regulation of FVIIIAb production in haemophilia.
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Nugent, Diane. "IDENTIFICATION OF ANTIPLATELET ANTIBODY IDIOTYPlSS ASSOCIATED WITH GLYCOPROTEIN Ib SPECIFICITY, PRESENT IN ITP PLASMA AND PRODUCED BY HUMAN HYBRIDOMAS FROM ITP SPLEEN CELL FUSIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644758.

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Platelet membrane glycoproteins (GP) express anumber of antigenic determinants important in theetiology of autoimmune thrombocytopenia. Sensitization to GPIb, although not the most frequent cause of ITP, leads to a particularly severe form ofthe disease. We have identified a number of casesof ITP in which GPIb bears the relevant immunogen. Using GPIb-specific autoantibodies isolated from the plasma of one such patient, we have produced a number of rabbit polyclonal and murine monoclonal anti-idiotypic antibodies. These antibodies recognize an idiotype expressed on the IgM antibody of this patient as well as IgG or IgM antibodies from several other patients with ITP, all of which can be shown to bind specifically to GPIb. Statistical analysis of a series of plasmas from normal individuals and thrombocytopenic patients demonstrated that there is a very strong correlation between the presence of the idiotype and GPIb reactivity, (p &lt; 0.00001). These anti-idiotypic antibodies are useful for the detection and characterization of GPIb-specific antibodies in the sera of patients with a clinically severe form of ITP. The classification of patients bearing this idiotype in their plasma may be useful in predicting disease outcome, thus identifying a group of ITP patients in whom more aggressive therapeutic regimens may be indicated. The use of these reagents and the development of human B lymphoblastoid cell lines producing monoclonal anti-GPIb antibodies will serve to elucidate the clonal origin and cellular regulation of autoantibody production in this disease
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Okeley, Nicole M., Weiping Zeng, Matthew R. Levengood, et al. "Abstract 2890: Mechanistic evaluation of the anti-tumor activities of 2-fluorofucose alone and in combination with anti-idiotype vaccination." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2890.

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Lode, Holger N., Manuela Schmidt, Diana Seidel, et al. "Abstract A28: Generation and characterization of anti-idiotype antibody ganglidiomab as GD2 surrogate for immunotherapy of neuroblastoma." In Abstracts: AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; December 2-5, 2012; Miami, FL. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tumimm2012-a28.

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Reports on the topic "Anti-idiotype"

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Iandolo, John J., and Stephen K. Chapes. Anti-Idiotype Probes for Toxin Detection. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada242099.

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