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Relevant bibliographies by topics / Anti-inflammatory drugs/pharmacology / Dissertations / Theses

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Dissertations / Theses on the topic 'Anti-inflammatory drugs/pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Hashim, Hadida. "Transdermal delivery of anti-inflammatory drugs." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254952.

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2

Hawkins, Neil. "The pharmacology of primary afferent C-fibres." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241558.

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3

Lipscomb, George Robert. "Gastric mucosal adaption to non-steroidal anti-inflammatory drugs in man." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362744.

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4

Kooloobandi, Azam. "The microbial transformation of 2-arylpropionic acids non-steroidal anti-inflammatory drugs." Thesis, University of Brighton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314804.

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5

Landoni, Maria Fabiana. "Pharmacokinetics and pharmacodynamics of non steroidal anti-inflammatory drugs in horses and calves." Thesis, Royal Veterinary College (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281664.

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6

Moride, Yola. "Exposure characterization and risk assessment in pharmacoepidemiology : non-steroidal anti-inflammatory drugs and gastro-intestinal bleeding." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41033.

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Exposure to drugs is a complex phenomenon. A method to characterize long term patterns of drug use amenable to analysis in the framework of risk assessment was developed. The impact of patterns was assessed with the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on upper gastro-intestinal bleeding (UGIB). A hospital based case-control study was conducted (244 cases age 68 and over, 615 matched controls). Objective data on all medications dispensed during the three years preceding admission were obtained from the Quebec prescription database. Patterns were expressed in terms of recenc

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7

Lakey, Rachel Louisa. "The effects of anti-inflammatory drugs on cartilage breakdown and their mechanism of action chondrocytes." Thesis, Northumbria University, 2008. http://nrl.northumbria.ac.uk/3118/.

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The progressive loss of cartilage matrix is a major characteristic of arthritic disease, ultimately leading to a loss of joint function. A number of therapeutics are used in the treatment of arthritic disease, with non-steroidal anti-inflammatory drugs used to treat the pain and inflammation seen in osteoarthritis and rheumatoid arthritis, whilst disease modifying anti-rheumatic drugs are used to slow disease progression. However it is not fully understood if and how many of these drugs effect the disease processes in arthritis. The objective of this study is to look at a number of therapeutic

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8

Aleong, Rosanne. "The effect of non-steroidal anti-inflammatory drugs on in vitro glial apolipoprotein E expression - implications for the mechanisms and treatment of Alzheimer's disease /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32747.

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Alzheimer's disease (AD) is a neurological disorder characterized by plaque deposition and an elevated immune response. Epidemiological studies have shown that use of non-steroidal anti-inflammatory drugs (NSAIDs) by the elderly is associated with a decreased relative risk and a delayed onset of AD. Moreover, the apolipoprotein E (apoE) gene has been proven to be a risk factor for AD with apoE &egr;4 AD patients having been found to show lower levels of brain apoE. In the present study, treatment of primary rat mixed glial cell cultures with indomethacin, aspirin, and interleukin-1beta resulte

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9

Cheng, Huiwen. "Effects of N-acetyl-L-cysteine and Nitric Oxide-releasing Nonsteroidal Anti-Inflammatory Drugs on Breast Cancer and Melanoma Cell Adhesion." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1384948906.

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10

Ding, Kai. "DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS AGAINST BOTH HUMAN AND MOUSE MICROSOMAL PROSTAGLANDIN E₂ SYNTHASE-1 ENZYMES." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/102.

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As the principal pro-inflammatory prostanoid, prostaglandin E2 (PGE2) serves as mediator of pain and fever in inflammatory reactions. The biosynthesis of PGE2 starts from arachidonic acid (AA). Cyclooxygenase (COX)-1 and/or COX-2 converts AA to prostaglandin H2 (PGH2), and PGE2 synthases transform PGH2 to PGE2. Current mainstream approach for treating inflammation-related symptoms remains the application of traditional non-steroidal anti-inflammatory drugs (tNSAIDs) and selective COX-2 inhibitors (coxibs). As both categories shut down the biosynthesis of all downstream prostanoids, their appli

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11

Dib, Ricardo Anuar. "Avaliação de sintomas e lesões esôfago-gastroduodenais secundários ao uso de antiinflamatórios." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-08112013-110643/.

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Introdução: Os antiinflamatórios não esteróides (AINEs), incluindo a aspirina, são drogas largamente utilizadas para tratamento das doenças inflamatórias e da dor, e que podem causar efeitos colaterais sérios, causando considerável morbidade e mortalidade, relacionadas á doença ulcerosa, duodenal e gástrica, particularmente ao sangramento gastrointestinal. O risco relativo global de complicações gastroduodenais é de três a dez vezes, maior nos usuários de AINEs, quando comparado com indivíduos sadios. Cerca de 25% dos usuários crônicos dos antiinflamatórios não esteroides (AINEs) deverão desen

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12

Bhala, Neeraj. "Coxibs and traditional NSAIDs : systematic overviews of the randomised evidence for the effects of traditional non-steroidal anti-inflammatory drugs and selective inhibitors of cyclo-oxygenase-2 on vascular and upper gastrointestinal outcomes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:2b6d8279-bce1-44bd-84c5-7658723786b2.

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<b>Background:</b> Comparative assessments of the vascular and upper gastrointestinal risks of different regimens of non-steroidal anti-inflammatory drugs (NSAIDs) are required. <b>Methods:</b> Meta-analyses were conducted, using individual participant data where possible, of placebo-controlled trials of a selective cyclo-oxygenase [COX]-2 inhibitor ('coxib') or traditional NSAID, or randomised trials of a coxib versus traditional NSAIDs. A prespecified subdivision of traditional NSAID regimens of those with antiplatelet activity (mainly naproxen) and those without (mainly diclofenac) was made

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13

Ribeiro, Geise. "Complexos de dirutênio com os fármacos ibuprofeno, ácido acetilsalicílico, naproxeno, indometacina, e com ácido y-linolêncio: Síntese, caracterização, avaliação da ação antiproliferativa sobre células tumorais e estudo da interação da unidade dimetálica com adenina e adenosina." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/46/46134/tde-20062016-183530/.

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Este trabalho tem como principal objetivo contribuir para o desenvolvimento de novos potenciais metalofármacos de rutênio. Nele são descritas a síntese, a caracterização e a avaliação da ação antiproliferativa de alguns complexos de dirutênio (II,III) com os fármacos antiinflamatórios não-esteróides (AINEs): ibuprofeno (ibp), ácido acetilsalicílico (aas), naproxeno (npx) e indometacina (ind) e também com o ácido γ-linolênico (lin), sobre células cancerígenas. Os compostos obtidos foram caracterizados por análise elementar, espectroscopia de absorção eletrônica, medidas de susceptibilidade

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14

Omile, Clement Ibe. "Analysis and pharmacokinetics of non-steroidal anti-inflammatory drug combinations in man." Thesis, University of Strathclyde, 1988. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21283.

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High Performance Liquid Chromatographic methods for quantifying 11 commonly used non-steroidal antiinflammatory drugs in serum were developed. Rapid, specific and sensitive adaptations of the methods were achieved by extraction with chloroform : acetonitrile 3:2 or diethylether : n-hexane 1:1 , giving recoveries of 85-98 %. The methods were used to study the in-vivo kinetic properties of aspirin in healthy volunteers when aspirin (652mg) was taken alone (I), with paracetamol (l000mg) (II) or with indomethacin (l00mg) (III) The salicylate absorption rate for I was 0.75 ± 0.03 hr⁻¹ (mean ± S.E.M

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15

Fredriksson, Sundbom Marcus. "Characterisation of anandamide uptake in resting and activated murine cells." Thesis, Umeå universitet, Farmakologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100031.

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Modifying the metabolism of the body’s own endocannabinoids is a novel approach for analgesia. Two key catabolic enzymes are fatty acid amide hydrolase (FAAH) and inflammation-inducible cyclooxygenase 2 (COX-2). The cellular uptake of the key endocannabinoid anandamide (AEA) has been found to be regulated by its FAAH-catalysed intracellular degradation, but COX-2 has not been investigated in this respect. We aimed to find out whether or not COX-2 in an in vitro inflammation setting would be able to gate AEA uptake. To achieve this, C6 cells and Raw 264.7 cells were stimulated with LPS/INF-γ an

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16

Grimm, Scott Wayne 1961. "THE EFFECT OF PIRFENIDONE ON CHRYSOTILE ASBESTOS-INDUCED PULMONARY FIBROSIS IN THE HAMSTER (ANTI-INFLAMMATORY DRUG)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276781.

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17

Ferguson, Shawn. "Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8909.

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The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX enzyme activity was measured in the M-1 cells, both indomethacin (COX-1 and -2 inhibitor) and the specific COX-2 inhibitor NS-398 effectively blocked PGE2 synthesis. These

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18

Snider, Sarah. "Glial Cell Modulators and Associated Anti-Inflammatory Activity: Implications in Reducing Methamphetamine Abuse-Related Behaviors in Rodents." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3404.

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Methamphetamine is a psychomotor stimulant that produces hyperactivity and euphoria and can lead to drug-seeking and abuse. An estimate from 2005 put the cost of methamphetamine abuse to society at an estimated 23.4 billion dollars. One of methamphetamine's effects is activation of glial cells and associated neuroinflammatory activity in the periphery and CNS. Glia are responsible for maintaining calcium homeostasis, neuroplasticity, immune activity, and cell signaling. Activation of glia and neuroinflammation are becoming recognized as links in drug abuse-related behavior. The goal of the pr

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19

Zein, Naïmah. "“CpdX”, a non-steroidal Selective Glucocorticoid Receptor Agonistic Modulator (SEGRAM) selectively triggers the beneficial anti-inflammatory activity of glucocorticoids, but not their long-term debilitating effects." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ088.

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Lors de la liaison d’un glucocorticoïde (GC) naturel ou synthétique (par exemple, la Dexaméthasone) au récepteur des glucocorticoïdes (GR), les GCs régulent l’expression de gènes cibles soit par (i) transactivation par liaison ‘’directe’’ à un élément de liaison à l’ADN de type ‘’(+)GRE’’, (ii) transrépression ‘’directe’’ par liaison à un élément de type ‘’nGRE’’ ou (iii) transrépression ‘’indirecte’’ par interaction physique directe avec des facteurs de transcription pro-inflammatoires tels que AP-1 et NF-κB. Les effets anti-inflammatoires bénéfiques des GCs sont généralement attribués à la t

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20

Domingues, Carolina Gomes. "Reacções imunológicas associadas aos anti-inflamatórios não-esteróides." Master's thesis, 2013. http://hdl.handle.net/10437/4608.

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Orientação: Filipe Inácio<br>As reacções de hipersensibilidade relacionadas com os anti-inflamatórios não-esteróides (AINEs) são muito comuns na população, sendo consideradas como a segunda causa para o aparecimento deste tipo de reacções. Os AINEs podem desencadear reacções de hipersensibilidade alérgicas (imediatas e tardias) e reacções não alérgicas. Clinicamente, esta hipersensibilidade pode ser manifestada a nível respiratório, cutâneo e sistémico. O diagnóstico, in vivo (testes cutâneos e testes de provocação oral, nasal e de inalação) ou teste in vitro (BAT, CAST, ASPIteste e TTL), é um

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21

Gameiro, Ana Filipa Pereira. "Utilização de própolis em medicamentos e produtos de saúde." Master's thesis, 2020. http://hdl.handle.net/10437/11836.

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Orientação: Catarina Baptista Fialho Rosado<br>O própolis é uma mistura complexa de material resinoso de coloração e consistência variada, colhida por abelhas a partir de secreções e exsudados de rebentos. A sua composição química tem vindo a ser cada vez mais estudada, contudo, é difícil padronizar, visto que a composição varia entre regiões e é sazonal. Contudo, este produto natural apresenta uma vasta gama de propriedades bioativas, destacando-se as propriedades antioxidante, antimicrobiana e antiinflamatória, estando associada à predominância de compostos fenólicos. Apesar da sua pop

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22

Antão, Ana Margarida Ribeirinha. "Estudo de compostos bioactivos e actividades biológicas de Plectranthus ecklonii Benth." Master's thesis, 2015. http://hdl.handle.net/10437/6177.

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Orientação: Patrícia Rijo<br>O uso de produtos à base de plantas para o tratamento, cura e prevenção de doenças, constitui uma das mais antigas práticas medicinais da humanidade. De facto, uma fracção significativa das populações dos países em desenvolvimento permanece dependente dos conhecimentos ancestrais sobre plantas para os seus cuidados de saúde. Ainda assim, continua a existir uma lacuna entre os progressos observados na farmácia clínica e os no campo da fitoterapia e da medicina tradicional, continuando muitos produtos naturais com actividade biológica por identificar. As espécies de

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23

Rasool, Yusuf. "An evaluation of the anti-inflammatory activity and mechanism of action of three novel auronofin derivatives." 2008. http://upetd.up.ac.za/thesis/available/etd-02242009-160331.

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24

Busch, F., A. Mobasheri, P. Shayan, C. Lueders, R. Stahlmann, and M. Shakibaei. "Resveratrol modulates interleukin-1beta-induced phosphatidylinositol 3-kinase and nuclear factor kappaB signaling pathways in human tenocytes." 2012. http://hdl.handle.net/10454/5903.

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Resveratrol, an activator of histone deacetylase Sirt-1, has been proposed to have beneficial health effects due to its antioxidant and anti-inflammatory properties. However, the mechanisms underlying the anti-inflammatory effects of resveratrol and the intracellular signaling pathways involved are poorly understood. An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1beta-mediated inflammatory signaling. Resveratrol suppressed IL-1beta-induced activation of NF-kappaB and PI3K in a dose- and time-dependent manner. Treatment with resveratrol enhan

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