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Journal articles on the topic 'Anti ischemic'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sanz, E., D. Garcia Dorado, J. Oliveras, et al. "Dissociation between anti-infarct effect and anti-edema effect of ischemic preconditioning." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 1 (1995): H233—H241. http://dx.doi.org/10.1152/ajpheart.1995.268.1.h233.

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This study tested the hypothesis that preconditioning, by reducing catabolite accumulation during ischemia, reduces osmotic swelling and myocardial necrosis during subsequent reperfusion. Farm pigs were randomly allocated to one of three groups of treatment: a control group undergoing a 48-min coronary occlusion (CO) of the middle left anterior descending artery, a preconditioned group (2 cycles of 5-min CO and 5-min reperfusion before the 48-min CO), or an intracoronary perfusion group receiving a substrate-free anoxic buffer perfusion into the area at risk between minutes 5 and 10 of the pro

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Zeng, Xian-Si, Wen-Shuo Geng, Lei Chen, and Jin-Jing Jia. "Thioredoxin as a Therapeutic Target in Cerebral Ischemia." Current Pharmaceutical Design 24, no. 25 (2018): 2986–92. http://dx.doi.org/10.2174/1381612824666180820143853.

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Background: Cerebral ischemia is a common cause of disability and death. Ischemic brain injury results from complex pathological processes, including oxidative stress, inflammation, and apoptosis. Thioredoxin( Trx) is an important multifunctional protein, which regulates cellular redox status. Increasing studies have demonstrated that Trx provides a neuroprotective role against cerebral ischemia-induced injury. Methods: A systematic search of PMC and the PubMed Database was conducted to summarize the protective effects of Trx against cerebral ischemia. Results: This article reviews the underst

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Bertelmann, Thomas, Hans Ulrich Frank, Hendrik Ansgar Fuchs, and Nicolas Feltgen. "Branch Retinal Vein Occlusion, Macular Ischemia, and Intravitreal Anti-VEGF Therapy." Case Reports in Ophthalmology 8, no. 1 (2017): 271–78. http://dx.doi.org/10.1159/000475520.

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Purpose: To report a case with ischemic macular edema (ME) due to an acute branch retinal vein occlusion (BRVO) which was treated with repeated intravitreal anti-VEGF injections. Methods: Retrospective case presentation. Results: A 66-year-old female patient was treated with repeated intravitreal anti-VEGF injections due to ischemic ME following an acute BRVO. Over a period of 2.5 years best corrected visual acuity increased from 0.06 to 0.6 (decimal notation) accompanied by a reduction in central retinal thickness from 546 to 292 µm. Overall 17 anti-VEGF injections were administered to treat

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Pluta, Ryszard, Sławomir Januszewski, and Stanisław J. Czuczwar. "Myricetin as a Promising Molecule for the Treatment of Post-Ischemic Brain Neurodegeneration." Nutrients 13, no. 2 (2021): 342. http://dx.doi.org/10.3390/nu13020342.

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The available drug therapy for post-ischemic neurodegeneration of the brain is symptomatic. This review provides an evaluation of possible dietary therapy for post-ischemic neurodegeneration with myricetin. The purpose of this review was to provide a comprehensive overview of what scientists have done regarding the benefits of myricetin in post-ischemic neurodegeneration. The data in this article contribute to a better understanding of the potential benefits of myricetin in the treatment of post-ischemic brain neurodegeneration, and inform physicians, scientists and patients, as well as their

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Pluta, Ryszard, Barbara Miziak, and Stanisław J. Czuczwar. "Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids." Molecules 28, no. 15 (2023): 5624. http://dx.doi.org/10.3390/molecules28155624.

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Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy, amyloid plaques, neurofibrillary tangles, and ultimately neuronal death. In addition, genetic factors such as post-ischemic changes in genetic programming in the expression of amyloid protein precursor, β-secretase, presenilin-1 and -2, and tau protein play an important role in the

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Khabibulina, M., D. Elistratov, and M. Shamilov. "Anti-ischemic and cardiometabolic therapy in cardiovascular pathology." Vrach 35, no. 4 (2024): 47–50. http://dx.doi.org/10.29296/25877305-2024-04-09.

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The purpose of this study was to study the effect of Kardioton therapy on myocardial ischemia in patients with arterial hypertension. The drug Kardioton is a natural cardioprotector; strengthens the heart muscle by improving its oxygen supply, stops inflammatory processes in the myocardium; has anti-ischemic, cardiometabolic, hypotensive effect. It is recommended for disorders of the cardiovascular system, with increased physical activity. Based on the conducted research, it can be concluded that Kardioton is well tolerated by patients and is an effective treatment: cardiometabolic and anti-is

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Lin, Ming-Cheng, Chien-Chi Liu, Yu-Chen Lin, and Chin-Sheng Liao. "Resveratrol Protects against Cerebral Ischemic Injury via Restraining Lipid Peroxidation, Transition Elements, and Toxic Metal Levels, but Enhancing Anti-Oxidant Activity." Antioxidants 10, no. 10 (2021): 1515. http://dx.doi.org/10.3390/antiox10101515.

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Cerebral ischemia is related to increased oxidative stress. Resveratrol displays anti-oxidant and anti-inflammatory properties. The transition elements iron (Fe) and copper (Cu) are indispensable for the brain but overload is deleterious to brain function. Aluminum (Al) and arsenic (As) are toxic metals that seriously threaten brain health. This study was conducted to elucidate the correlation of the neuroprotective mechanism of resveratrol to protect cerebral ischemic damage with modulation of the levels of lipid peroxidation, anti-oxidants, transition elements, and toxic metals. Experimental

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Baranova, Ksenia, Natalia Nalivaeva, and Elena Rybnikova. "Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning." International Journal of Molecular Sciences 24, no. 23 (2023): 17032. http://dx.doi.org/10.3390/ijms242317032.

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This review summarizes the currently known biochemical neuroadaptive mechanisms of remote ischemic conditioning. In particular, it focuses on the significance of the pro-adaptive effects of remote ischemic conditioning which allow for the prevention of the neurological and cognitive impairments associated with hippocampal dysregulation after brain damage. The neuroimmunohumoral pathway transmitting a conditioning stimulus, as well as the molecular basis of the early and delayed phases of neuroprotection, including anti-apoptotic, anti-oxidant, and anti-inflammatory components, are also outline

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Pluta, Ryszard, Marzena Ułamek-Kozioł, and Stanisław Czuczwar. "Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype." International Journal of Molecular Sciences 19, no. 12 (2018): 4002. http://dx.doi.org/10.3390/ijms19124002.

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In recent years, ongoing interest in ischemic brain injury research has provided data showing that ischemic episodes are involved in the development of Alzheimer’s disease-like neuropathology. Brain ischemia is the second naturally occurring neuropathology, such as Alzheimer’s disease, which causes the death of neurons in the CA1 region of the hippocampus. In addition, brain ischemia was considered the most effective predictor of the development of full-blown dementia of Alzheimer’s disease phenotype with a debilitating effect on the patient. Recent knowledge on the activation of Alzheimer’s d

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LAWSON, CLIVE S., and DAVID J. HEARSE. "Ischemic Preconditioning against Arrhythmias: An Anti-Arrhythmic or an Anti-Ischemic Phenomenon?" Annals of the New York Academy of Sciences 723, no. 1 (1994): 138–57. http://dx.doi.org/10.1111/j.1749-6632.1994.tb36723.x.

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Lee, Kuo-Hua, Wei-Cheng Tseng, Chih-Yu Yang, and Der-Cherng Tarng. "The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury." International Journal of Molecular Sciences 20, no. 14 (2019): 3529. http://dx.doi.org/10.3390/ijms20143529.

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Ischemia-reperfusion injury (IRI) plays a significant role in the pathogenesis of acute kidney injury (AKI). The complicated interaction between injured tubular cells, activated endothelial cells, and the immune system leads to oxidative stress and systemic inflammation, thereby exacerbating the apoptosis of renal tubular cells and impeding the process of tissue repair. Stem cell therapy is an innovative approach to ameliorate IRI due to its antioxidative, immunomodulatory, and anti-apoptotic properties. Therefore, it is crucial to understand the biological effects and mechanisms of action of

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Chao, Windsor Wen-Jin, Howard Wen-Haur Chao, Hung-Fu Lee, and Hsiao-Ming Chao. "The Effect of S-Allyl L-Cysteine on Retinal Ischemia: The Contributions of MCP-1 and PKM2 in the Underlying Medicinal Properties." International Journal of Molecular Sciences 25, no. 2 (2024): 1349. http://dx.doi.org/10.3390/ijms25021349.

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Retinal ischemia plays a vital role in vision-threatening retinal ischemic disorders, such as diabetic retinopathy, age-related macular degeneration, glaucoma, etc. The aim of this study was to investigate the effects of S-allyl L-cysteine (SAC) and its associated therapeutic mechanism. Oxidative stress was induced by administration of 500 μM H2O2 for 24 h; SAC demonstrated a dose-dependent neuroprotective effect with significant cell viability effects at 100 μM, and it concurrently downregulated angiogenesis factor PKM2 and inflammatory biomarker MCP-1. In a Wistar rat model of high intraocul

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Gilyarevskiy, S. R., and O. N. Tkacheva. "Current ideas about the role of ranolazine in patients’ treatment with angina pectoris." Meditsinskiy sovet = Medical Council, no. 23 (January 18, 2024): 26–31. http://dx.doi.org/10.21518/ms2023-456.

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The article presents modern views on the role of the anti-ischemic agent, ranolazine, in the treatment of a wide range of patients with angina pectoris. It also provides data on a percentage increase in the number of patients with chronic coronary artery disease who need improved anti-ischemic therapy. The need to use alternative agents for the treatment of angina, which is highlighted in the article, is determined by a percentage increase in the number of elderly and senile patients with angina, as such patients often have concomitant diseases that limit the use of haemodynamic anti-ischemic

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Yepanchintseva, O. A., H. I. Prykashchykova та O. J. Zharinov. "Кардіопротекторні ефекти зофеноприлу: механізми реалізації та клінічне значення". Cardiac Surgery and Interventional Cardiology 14, № 1 (2025): 35–43. https://doi.org/10.31928/2664-3790-2025.1.3543.

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The aim – to analyze and summarize experimental and clinical data on the cardio- and vasoprotective mechanisms of zofenopril and to determine its clinical significance in patients with high cardiovascular riskAn analytical review of the literature on the antioxidant, anti-ischemic, and anti-inflammatory effects of zofenopril was conducted. The results of the long-term SMILE clinical research program, which investigated the effect of zofenopril on the course of acute myocardial infarction, left ventricular dysfunction, and myocardial ischemia, were also analyzed. Zofenopril exhibits pronounced

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Ułamek-Kozioł, Marzena, Stanisław J. Czuczwar, Sławomir Januszewski, and Ryszard Pluta. "Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia." International Journal of Molecular Sciences 21, no. 2 (2020): 517. http://dx.doi.org/10.3390/ijms21020517.

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Currently available pharmacological treatment of post-ischemia-reperfusion brain injury has limited effectiveness. This review provides an assessment of the current state of neurodegeneration treatment due to ischemia-reperfusion brain injury and focuses on the role of curcumin in the diet. The purpose of this review was to provide a comprehensive overview of what was published about the benefits of curcumin influence on post-ischemic brain damage. Some data on the clinical benefits of curcumin treatment of post-ischemic brain in terms of clinical symptoms and adverse reactions have been revie

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Clark, Wayne M., Ken P. Madden, Robert Rothlein, and Justin A. Zivin. "Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule." Journal of Neurosurgery 75, no. 4 (1991): 623–27. http://dx.doi.org/10.3171/jns.1991.75.4.0623.

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✓ Activated leukocytes appear to be directly involved in potentiating ischemic central nervous system (CNS) injury. Adhesion of leukocytes to endothelium is essential for their migration and requires the binding of adhesion receptors of the leukocyte (CD 18) to an intercellular adhesion molecule (ICAM) on endothelium. Monoclonal antibodies to an ICAM can block leukocyte adhesion and transendothelial migration. To determine the efficacy of anti-ICAM antibody treatment in preserving neurological function after CNS ischemia, two animal models were used. A 1-mg/kg dose of anti-ICAM was given to ra

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A., H. M. Nazmul Hasan, Jahid Hasan Sk., Anzam Ul Islam Md., Awal Trina Afsana, Nahar Deepa Kanij, and Asaduzzaman Md. "Pattern of Pharmacotherapy of Patients Having Ischemic Heart Disease at a Specialized Hospital in Dhaka, Bangladesh: A Survey Based Study on Patients Discharged from Hospital." British Journal of Medicine & Medical Research 22, no. 2 (2017): 1–9. https://doi.org/10.9734/BJMMR/2017/34107.

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<strong>Aims: </strong>Study on pharmacotherapeutic pattern on cardiovascular patients is rarely done. Patient’s demography, drug usage and its clinical outcome are the basis for the assessment of cardiac treatment. The aim of this study to analyze the demography of patients of ischemic heart disease along with drug usage and current trends of practice in Bangladesh. <strong>Methods: </strong>This study was carried out over a period of two months at different units of NICVD, situated at Dhaka, Bangladesh. A structured questionnaire was prepared to collect necessary data from patients. Descript

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Gong, Haifan, Zhengwei Luo, Wenliang Chen, Zhong-Ping Feng, Guan-Lei Wang, and Hong-Shuo Sun. "Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection." Marine Drugs 16, no. 12 (2018): 516. http://dx.doi.org/10.3390/md16120516.

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Xyloketal B is a natural compound isolated from the mangrove fungus, Xylaria sp. in the South China Sea. In the past decade, studies have shown that xyloketal B exhibits anti-oxidative, anti-inflammatory, and anti-apoptotic abilities and may serve as a treatment for ischemic stroke. Xyloketal B has been shown to interact with both neurons and residential microglial cells and regulate a number of proteins involved in the apoptotic events during ischemia. Such mechanisms include inhibition of specific NADPH oxidase subunits, upregulation of HO-1, increase of Bcl-1/Bax ratio, and downregulation o

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Kadatuan, Makalutang M. "New Oral Anticoagulants in Addition to Dual Anti-platelet Therapy After an Acute Coronary Syndrome: A Systematic Review of Randomized Controlled Trials." Philippine Journal of Cardiology 41, no. 1 (2013): 23–29. http://dx.doi.org/10.69944/pjc.13aef419bc.

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BACKGROUND: Despite important advances in the treatment of acute coronary syndrome (ACS), the risk of recurrent ischemic events remains high. This generates interest for improved antithrombotic therapy in addition to the current standard management of dual anti-platelet therapy. OBJECTIVES: This study aimed to evaluate randomized controlled trials on the efficacy and safety of new oral anticoagulants (NOACs) compared with placebo in patients receiving dual anti-platelet therapy after an ACS. METHODS: An engine search using Pub Med database, Cochrane Central Registry of Controlled trials and Cl

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Yergöz, Fatih, Julian Friebel, Nicolle Kränkel, et al. "Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts." Cells 10, no. 8 (2021): 2130. http://dx.doi.org/10.3390/cells10082130.

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Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. This study analyzed the role of ANT1 in the immune response of ischemic heart tissue. Ischemic ANT1 overexpressing hearts experienced a shift toward an anti-inflammatory immune response. The shift was characterized by low interleukin (IL)-1β expression and M1 macrophage infiltration, whereas M2 macrophage infiltration and levels of IL-10, IL-4, and transforming growth factor (TGFβ) were increased. The modulated immune response correlated with high mitochon

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Abbas, Eslam, Ahmed Mahdy, and Shady Mansy. "Relentless Angina of a Scarred Heart." Cardiology and Cardiovascular Research 8, no. 4 (2024): 92–95. https://doi.org/10.11648/j.ccr.20240804.11.

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Refractory anginal pain affects nearly 5-10% of stable coronary artery disease patients, and maximizing the anti-ischemic medical therapy is the standard first-line treatment. The presence of a scarred myocardial territory of the epicardial coronary chronic total occlusion (CTO) limits the implementation of other modalities, such as angioplasty and surgical bypass. Accordingly, this subset of patients, who show poor response to medical treatment with the absence of considerable reversible ischemia, bears an additional burden of persistent angina besides the structural and functional complicati

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Makkiyah, Feda. "UPDATE REVIEW OF PHYSALIS: ETHNOGRAPHY VALUE AND ITS USEFULNESS IN STROKE ISCHEMIC DISEASE." Journal of Research in Pharmacy and Pharmaceutical Sciences 2, no. 2 (2023): 48–51. http://dx.doi.org/10.33533/jrpps.v2i2.7232.

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One Indonesian herbal medicine that deserves attention is Physalis minimal Linn. Identifying medications and their use in the correct dosages is crucial for effective treatment. Country gooseberry, or Physalis minima Linn, has anti-cancer, anti-diabetic, analgesic, antipyretic, and anti-inflammatory properties. This paper aims to reveal the potential use of Physalis minima Linn in stroke ischemic disease, a substantial current health issue in Indonesia. We used Scopus and Google databases to screen the intended articles with keywords used are TITLE-ABS- KEY (stroke) AND physalis AND antioxidan

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Cheng, Chin-Yi, and Yu-Chen Lee. "Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/5739434.

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Inflammation plays a crucial role in the pathophysiology of acute ischemic stroke. In the ischemic cascade, resident microglia are rapidly activated in the brain parenchyma and subsequently trigger inflammatory mediator release, which facilitates leukocyte-endothelial cell interactions in inflammation. Activated leukocytes invade the endothelial cell junctions and destroy the blood-brain barrier integrity, leading to brain edema. Toll-like receptors (TLRs) stimulation in microglia/macrophages through the activation of intercellular signaling pathways secretes various proinflammatory cytokines

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Stanton, Marshall S. "Anti-ischemic effect of pravastatin." Cardiology in Review 5, no. 1 (1997): 2. http://dx.doi.org/10.1097/00045415-199701000-00005.

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Hashem, S. "Anti platelet in ischemic strokes." Revue Neurologique 163, no. 4 (2007): 491. http://dx.doi.org/10.1016/s0035-3787(07)90451-8.

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Chao, Howard Wen-Haur, Windsor Wen-Jin Chao та Hsiao-Ming Chao. "Catalpol Protects Against Retinal Ischemia Through Antioxidation, Anti-Ischemia, Downregulation of β-Catenin, VEGF, and Angiopoietin-2: In Vitro and In Vivo Studies". International Journal of Molecular Sciences 26, № 9 (2025): 4019. https://doi.org/10.3390/ijms26094019.

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Retinal ischemic disorders present significant threats to vision, characterized by inadequate blood supply oxygen–glucose deprivation (OGD), oxidative stress, and cellular injury, often resulting in irreversible injury. Catalpol, an iridoid glycoside derived from Rehmannia glutinosa, has demonstrated antioxidative and neuroprotective effects. This study aimed at investigating the protective effects and mechanisms of catalpol against oxidative stress or OGD in vitro and retinal ischemia in vivo, focusing on the modulation of key biomarkers of retinal ischemia, including HIF-1α, vascular endothe

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Zhu, Zi-Yi, Bin Yan, and Jing Luo. "Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy." International Journal of Ophthalmology 14, no. 11 (2021): 1647–52. http://dx.doi.org/10.18240/ijo.2021.11.01.

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In recent years, retinal ischemia such as that which occurs in diabetic retinopathy (DR) and retinal vein occlusion (RVO) has become a hotspot of ischemic retinopathy research. High levels of vascular endothelial growth factor (VEGF) are recognized as a major cause of macular edema (ME) in DR and RVO. High concentrations of VEGF in the vitreous can lead to serious retinal ischemia and hypoxia and form retinal nonperfusion areas (NPAs). Different levels of retinal ischemia can represent disease severity and progression. Anti-VEGF therapy as the first-line treatment for ME has been found to be e

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Lin, Ming-Cheng, Chien-Chi Liu, Yu-Chen Lin, and Ching-Wen Hsu. "Epigallocatechin Gallate Modulates Essential Elements, Zn/Cu Ratio, Hazardous Metal, Lipid Peroxidation, and Antioxidant Activity in the Brain Cortex during Cerebral Ischemia." Antioxidants 11, no. 2 (2022): 396. http://dx.doi.org/10.3390/antiox11020396.

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Cerebral ischemia induces oxidative brain injury via increased oxidative stress. Epigallocatechin gallate (EGCG) exerts anti-oxidant, anti-inflammatory, and metal chelation effects through its active polyphenol constituent. This study investigates whether EGCG protection against cerebral ischemia-induced brain cortex injury occurs through modulating lipid peroxidation, antioxidant activity, the essential elements of selenium (Se), zinc (Zn), magnesium (Mg), copper (Cu), iron (Fe), and copper (Cu), Zn/Cu ratio, and the hazardous metal lead (Pb). Experimentally, assessment of the ligation group

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Oh, Dong-Jin, Belda Dursun, Zhibin He, et al. "Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice." American Journal of Physiology-Renal Physiology 294, no. 1 (2008): F264—F271. http://dx.doi.org/10.1152/ajprenal.00204.2007.

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Fractalkine (CX3CL1) is expressed on injured endothelial cells and is a potent chemoattractant and adhesion molecule for macrophages carrying the fractalkine receptor (CX3CR1). The aim of this study was to investigate the role of CX3CL1, and its ligand CX3CR1, in ischemic acute renal failure (ARF) in mice. On immunoblotting, CX3CL1 protein expression in the kidney increased markedly in ischemic ARF. On immunofluorescence staining, the intensity of CX3CL1 staining in blood vessels was significantly more prominent in ischemic ARF compared with controls. A specific anti-CX3CR1 antibody (25 μg ip

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Wang, Lei, Xu Zhang, Xiaoxing Xiong, et al. "Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke." Antioxidants 11, no. 12 (2022): 2377. http://dx.doi.org/10.3390/antiox11122377.

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Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there are limited effective clinical treatments for cerebral ischemic stroke, and the recovery of cerebral blood circulation will lead to cerebral ischemia-reperfusion injury (CIRI). Cerebral ischemic stroke involves many pathological processes such as oxidative stress, inflammation, and mitochondrial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2), as one of the most critical antioxidant transcript

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Kang, Bo Kyung, Mi Kyoung Kim, So Young Kim, et al. "Anti-Neuroinflammatory Effects of Uncaria sinensis in LPS-Stimulated BV2 Microglia Cells and Focal Cerebral Ischemic Mice." American Journal of Chinese Medicine 43, no. 06 (2015): 1099–115. http://dx.doi.org/10.1142/s0192415x15500639.

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Uncaria sinensis (US) has long been used as a traditional Korean medicine to treat cardiovascular and central nervous system diseases, including hypertension and cerebral ischemia. Several recent studies have indicated that US has neuroprotective and cerebrovascular protective effects in ischemic brain injury; however, little is known about the anti-inflammatory effects of US. Therefore, the present study was designed to validate the anti-inflammatory effects of US. The anti-neuroinflammatory properties of US on pro-inflammatory mediators were investigated in lipopolysaccharide (LPS)-stimulate

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Lytvynenko, N., and M. Yu Delva. "Thiazolidinediones and ischemic stroke (literature review and reasoning for the new potential treatment approaches)." NATIONAL JOURNAL OF NEUROLOGY, no. 2 (January 19, 2019): 26–34. http://dx.doi.org/10.28942/nnj.v1i2.228.

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Stroke is a leading cause of death and disability among adult population. Many pathological events including inflammation, oxidative stress, and apoptosis contribute to the secondary neuronal death after stroke. The goal of this review is to discuss the therapeutic potential and putative mechanisms of neuroprotective properties of thiazolidinediones (peroxisome proliferator-activated receptors-γ agonists) at ischemic stroke. Thiazolidinediones have insulin-sensitizing and other additional pleiotropic properties. Ischemic neuroprotection afforded by thiazolidinediones has been involved anti-inf

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Lytvynenko, N., and M. Yu Delva. "THIAZOLIDINEDIONES AND ISCHEMIC STROKE (LITERATURE REVIEW AND REASONING FOR THE NEW POTENTIAL TREATMENT APPROACHES)." National Journal of Neurology 2, no. 02 (2012): 40–48. http://dx.doi.org/10.61788/njn.v2i12.05.

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Stroke is a leading cause of death and disability among adult population. Many pathological events including inflammation, oxidative stress, and apoptosis contribute to the secondary neuronal death after stroke. The goal of this review is to discuss the therapeutic potential and putative mechanisms of neuroprotective properties of thiazolidinediones (peroxisome proliferator-activated receptors-? agonists) at ischemic stroke. Thiazolidinediones have insulin-sensitizing and other additional pleiotropic properties. Ischemic neuroprotection afforded by thiazolidinediones has been involved anti-inf

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Setorki, Mahbubeh, and Zahra Hooshmandi. "Neuroprotective effect of Ziziphus spina-christi on brain injury induced by transient global cerebral ischemia and reperfusion in rat." Bangladesh Journal of Pharmacology 12, no. 1 (2017): 69. http://dx.doi.org/10.3329/bjp.v12i1.29964.

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<p class="Abstract">This study evaluated the protective effect of <em>Ziziphus </em>spina<em>-</em>christi on the cerebral oxidative stress and damage induced by ischemia. Male Wistar rats were divided randomly into six groups (seven in each group): Control group did not undergo surgery and received distilled water; shame group underwent surgery without ischemia; ischemic group underwent ischemia without any medication; extract-treated groups underwent ischemia and orally received 50, 100, 200 mg/kg/day doses <em>Z. </em>spina<em>-</em>chri

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Shabelnikova, Anna, Anna Peresypkina, Viktoriya Gubareva, et al. "PHARMACOLOGICAL PRECONDITIONING BY RECOMBINANT ERYTHROPOIETIN AS THE POSSIBILITY OF INCREASING THE STABILITY OF TISSUE OF THE RETINA TO REPERFUSION ISCHEMIA IN EXPERIMENT." Research Results in Pharmacology 2, no. (1) (2016): 25–29. https://doi.org/10.18413/2313-8971-2016-2-1-25-29.

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Ischemic injury was formed in laboratory rats by applying mechanical pressure (110 mm Hg) to the anterior eye chamber for 30 minutes. The experiment revealed that the recombinant erythropoietin (50 IU/kg) prevents the development of degenerative changes in retinal layers caused by ischemic injury. Intensity of the protective effect of erythropoietin on the retina of rats was assessed after 1 hour and 72 hours of reperfusion after pathology simulation. The observed protective effect of erythropoietin with the development of ischemia was confirmed by laser Doppler flowmetry, electroretinography

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Gunduz, Ozgur, Melike Sapmaz-Metin, Ruhan Deniz Topuz, Oktay Kaya, Cetin Hakan Karadag, and Ahmet Ulugol. "Anti-Inflammatory and Antipruritic Effects of Remote Ischaemic Postconditioning in a Mouse Model of Experimental Allergic Contact Dermatitis." Medicina 59, no. 10 (2023): 1816. http://dx.doi.org/10.3390/medicina59101816.

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Background and Objectives: Allergic contact dermatitis is a common type IV hypersensitivity reaction characterised by redness, itching, oedema and thickening of the skin. It occurs in about 7% of the population and its incidence is increasing. It has been observed that the preconditioning of tissues by exposing them to transient ischemia increases resistance to subsequent permanent ischemia, and this phenomenon is called ischemic preconditioning. It has been shown that conditioning in one organ can also protect other organs. The protective effect of remote ischemic preconditioning is thought t

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Gulyaev, Sergey M., Vasiliy V. Taraskin, and Ekaterina Z. Urbanova. "Adaptogenic effect of phlojodicarpus sibiricus extract on cerebral ischemia." Reviews on Clinical Pharmacology and Drug Therapy 17, no. 2 (2019): 63–66. http://dx.doi.org/10.17816/rcf17263-66.

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The aim of the study was to determine the adaptogenic effect of the extract from the roots of Phlojodicarpus sibiricus during ischemic influence on the left hemisphere of the brain. Experiments were conducted on Wistar rats of both sexes weighing 200-220 g. Unilateral cerebral ischemia was induced by permanent occlusion of the left common carotid artery under ether anesthesia. Adaptogenic anti-ischemic effect of Ph. sibiricus was determined by the number of desquamated endotheliocytes, nitrogen oxide metabolites – nitrites in the blood, by the content of lipid peroxidation products – malondial

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Chamorro, Beatriz, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, et al. "Neuroprotective and Antioxidant Properties of Cholestero Nitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death." Antioxidants 12, no. 7 (2023): 1364. http://dx.doi.org/10.3390/antiox12071364.

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Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy. The abundance of information available on the molecular pathophysiology of ischemic stroke has sparked considerable interest in developing new neuroprotective agents that can target different events of the ischemic cascade and may be used in combination with existing treatments. In this regard, nitrones represent a very promising alternative due to their renowned antioxidant and anti-inflammatory effects. In this study,

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Loyola Bolognesi, Luciano Josué, and Marcelo Adrián Estrin. "Impact of diclofenac use on the incidence and severity of ischemic colitis: A systematic rewiew." South Health and Policy 4 (May 10, 2025): 196. https://doi.org/10.56294/shp2025196.

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Introduction: Ischemic colitis is inflammation of the colon caused by decreased blood flow, being the most frequent form of intestinal ischemia. Symptoms can be mild to severe complications such as intestinal perforation. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), which is commonly used, has been associated with various gastrointestinal complications. Currently, several studies have suggested a possible relationship between diclofenac use and ischemic colitis. Objective: To evaluate the impact of diclofenac use on the incidence and severity of ischemic colitis through a system

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Liang, Bruce T., Tomasz A. Swierkosz, Howard C. Herrmann, Stephen Kimmel, and Kenneth A. Jacobson. "Adenosine and Ischemic Preconditioning." Current Pharmaceutical Design 5, no. 12 (1999): 1029–41. http://dx.doi.org/10.2174/1381612805666230112212126.

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Adenosine is released in large amounts during myocardial ischemia and is capable of exerting potent cardioprotective effects in the heart. Although these observations on adenosine have been known for a long time, how adenosine acts to achieve its anti-ischemic effect remains incompletely understood. However, recent advances on the chemistry and pharmacology of adenosine receptor ligands have provided important and novel information on the function of adenosine receptor subtypes in the cardiovascular system. The development of model systems for the cardiac actions of adenosine has yielded impor

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Chopp, Michael, Yi Li, Ning Jiang, Rui Lan Zhang, and Jonathan Prostak. "Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain." Journal of Cerebral Blood Flow & Metabolism 16, no. 4 (1996): 578–84. http://dx.doi.org/10.1097/00004647-199607000-00007.

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We tested the hypothesis that treatment of transient focal cerebral ischemia in rat with antibodies directed against adhesion molecules reduces apoptosis. Rats (n = 31) were subjected to 2 h of middle cerebral artery (MCA) occlusion induced by intraluminal insertion of a nylon monofilament into the internal carotid artery. Upon reperfusion, animals were treated with monoclonal antibodies directed against intercellular adhesion molecule (ICAM)-1) (n = 8) or integrin CD11b/CD18 (n = 10), or administered IgG1 as a control (n = 13). At 48 h after ischemia, animals were killed and the brains analyz

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Lardizabal, Joel A., and Prakash C. Deedwania. "The Anti-Ischemic and Anti-Anginal Properties of Statins." Current Atherosclerosis Reports 13, no. 1 (2010): 43–50. http://dx.doi.org/10.1007/s11883-010-0147-y.

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Lee, Deokho, Zhongjie Fu, Ann Hellstrom, and Lois E. H. Smith. "Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases." International Journal of Molecular Sciences 25, no. 10 (2024): 5503. http://dx.doi.org/10.3390/ijms25105503.

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Appropriate nutrients are essential for cellular function. Dietary components can alter the risk of systemic metabolic diseases, including cardiovascular diseases, cancer, diabetes, and obesity, and can also affect retinal diseases, including age-related macular degeneration, diabetic retinopathy, and glaucoma. Dietary nutrients have been assessed for the prevention or treatment of retinal ischemic diseases and the diseases of aging. In this article, we review clinical and experimental evidence concerning the potential of some nutritional supplements to prevent or treat retinal ischemic diseas

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Bhuiyan, Mohammad Iqbal H., Shanshan Song, Hui Yuan, et al. "WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats." Journal of Cerebral Blood Flow & Metabolism 37, no. 8 (2016): 2780–94. http://dx.doi.org/10.1177/0271678x16675368.

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With-no-lysine kinase (WNK) and Na+-K+-2Cl− cotransporter 1 (NKCC1) are involved in the pathogenesis of hypertension. In this study, we investigated the WNK-NKCC1 signaling pathway in spontaneously hypertensive rats (SHR) and their associated susceptibility to stroke injury. Basal NKCC1 protein levels were higher in SHR than in normotensive Wistar Kyoto (WKY) rat brains. After inducing ischemic stroke, adult male WKY and SHR received either saline or NKCC1 inhibitor bumetanide (10 mg/kg/day, i.p.) starting at 3-h post-reperfusion. NKCC1 inhibition blunted the extent of ischemic infarction in S

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Chi-Hsun, Lien, Lin Yu-Chen, and Lin Ming-Cheng. "Protective Effect of Silibinin during Cerebral Ischemia is correlated with Altering Oxidative Stress, Transition Metal, and Antioxidant." Pharmaceutical and Chemical Journal 8, no. 3 (2021): 13–21. https://doi.org/10.5281/zenodo.13961789.

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Cerebral ischemia may elevate oxidative stress due to a large amount of the generated reactive oxygen species.<strong> </strong>Silibinin is an active component of flavonoids possessing anti-inflammatory and anti-oxidative properties.<strong> </strong>Transition metal of iron (Fe), copper (Cu), and antioxidant of superoxide dismutase (SOD) and catalase (CAT) are required for the brain functions. This study was to elucidate whether protective effect of silibinin on the ischemic brain cortex is correlated with altering the level of transition metal, oxidative stress, and antioxidant activity. Ra

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Pandey, Haushila Prasad, Vaibhav Mishra, and Dr Akanksha. "New Remedies from Natural Products in Brain Stroke." Journal of Universal College of Medical Sciences 4, no. 2 (2018): 35–39. http://dx.doi.org/10.3126/jucms.v4i2.19090.

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Acute ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability. Despite advances in the understanding of the pathophysiology of cerebral ischemia, therapeutic options remain limited. Only recombinant tissue-plasminogen activator (rt-PA) for thrombolysis is currently approved for use in the treatment of stroke. However, its use is limited by its short therapeutic window (three hours), complications derived essentially from the risk of haemorrhage, and the potential damage from reperfusion/ischemic injury. Two important pathophysiological mechanisms

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Kabiri, Najmeh, and Mahbubeh Setorki. "Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat." Bangladesh Journal of Pharmacology 11, no. 3 (2016): 675. http://dx.doi.org/10.3329/bjp.v11i3.27014.

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<p>The aim of study was to investigate the potential neuroprotective effects of Kombucha on cerebral damage induced by ischemia in rats (n=99). Cerebral infarct volume in the ischemic rats received Kombucha solution showed no significance alteration. However, the permeability of blood-brain barrier significantly decreased in both ischemic rats received 15 mg/kg Kombucha tea and Sham group. In addition, brain water content in the ischemic groups treated with Kombucha solution was significantly higher than the Sham group, although right hemispheres in all of the treated groups illustrated

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Harpey, Catherine, Pascale Clauser, Claude Labrid, Jean-Louis Freyria, and Jean-Pierre Poirier. "Trimetazidine, A Cellular Anti-ischemic Agent." Cardiovascular Drug Reviews 6, no. 4 (1988): 292–312. http://dx.doi.org/10.1111/j.1527-3466.1988.tb00381.x.

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Boden, William E. "Ranolazine and Its Anti-Ischemic Effects." Journal of the American College of Cardiology 56, no. 12 (2010): 943–45. http://dx.doi.org/10.1016/j.jacc.2010.07.010.

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Suzuki, Sakiko, Takakazu Kawamata, Yoshikazu Okada, Tomonori Kobayashi, Tomoyuki Nakamura, and Tomokatsu Hori. "Filtrate ofPhellinus linteusBroth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/nen091.

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Phellinus linteus, a natural growing mushroom, has been known to exhibit anti-tumor, anti-inflammatory, anti-allergic and anti-oxidant effects. Aiming to exploit the neuroprotective effects ofP. linteus, we evaluated its effects on infarct volume reduction in a rat model of focal cerebral ischemia. Male Sprague-Dawley rats were subjected to right middle cerebral artery occlusion. Filtrate ofP. linteusbroth culture (various doses), fractionated filtrate (based on molecular weight) or control medium was administered intraperitoneally to rats before or after ischemia induction. Rats were killed a

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