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Dissertations / Theses on the topic 'Anti-metastatic effect'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Elkashef, Sara M. "Pharmacological evaluation of novel polysialyltransferase inhibitors as anti-metastatic agents and development of analytical methods for assessment of polysialylation inhibition : in vitro assessment of the effects of novel polysialyltransferase inhibitors on tumour cell function and development of quantitative HPLC-based methods for evaluation of novel polysialyltransferase inhibitors." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14123.

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Polysialic acid (polySia) is a carbohydrate polymer highly expressed during embryonic development but rarely expressed during postnatal development. Two polysialyltransferase (polyST) enzymes are responsible for the synthesis of polySia: ST8SiaII and ST8SiaIV. During oncogenesis polySia is re-expressed and it modulates cell-cell and cell-matrix adhesion, migration, invasion and metastasis. PolySia expression is strongly associated with poor clinical prognosis and correlates with aggressive and invasive disease in neuroblastoma and many other tumours. PolyST inhibition thus presents a novel, se

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Shiao, Cheng-Kai, and 蕭承愷. "The Anti-metastatic Effect of Glabridin in NCI-H460 Lung Cancer Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/52687014841490844293.

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碩士<br>中華醫事科技大學<br>生物科技系暨生物醫學研究所<br>103<br>Glabridin, isolated from Glycyrrhiza uralensis Linn., is a naturally occurring flavonoids in licorice. Some reports demonstrated that glabridin had various anti-carcinogenic properties. First, the result demonstrated glabridin could inhibit the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay, Boyden chamber invasion/migration assay, and wound healing assay. Data also showed glabridin could inhibit the enzyme activities and messenger RNA levels of matrix metalloproteinase-2/9 (MMP-2/MMP-9) and u-PA by gelatin zymography

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3

Huang, Sheng-Kai, and 黃聖凱. "Anti-metastatic effect of acridone alkaloids from twigs of Severinia buxifolia in NSCLC." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/j7eah7.

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碩士<br>高雄醫學大學<br>天然藥物研究所碩士班<br>106<br>Lung cancer is one of the most common cancer worldwide which is by far the leading cause of cancer death because of its rapid metastasis and poor prognosis. The incidence of lung cancer about 80% diagnosed with non-small lung cancer (NSCLC). Therefore, developing novel anti-cancer drugs to treat with NSCLC is indispensable. Serverinia buxifolia, a common folk medicine used in Southeast Asia, which displays many pharmacological activities such as anti-malaria, anti-rheumatism, and anti-nociceptive. Acridone alkaloids [atalaphyllidine (Sbs-A), atalaphyllinine

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4

Wang, Ｙa-Ling, and 翁雅玲. "Anti-metastatic effect achieved by oral administration of resveratrol on BALB/c mice challenged with CT26 tumor cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/27605823301766634752.

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碩士<br>國立嘉義大學<br>食品科學系研究所<br>95<br>Multiple bioactivities of resveratrol such as prevention of cardiovascular disease, anti-cancer and extension of lifespan have been demonstrated. Among its anti-cancer activities, anti-metastasis has been meagerly studied. In this study, pulmonary metastasis of BALB/c mice challenged with CT26 of colorectal adenocarcinoma cells as affected by oral administration with different doses of resveratrol was examined. Tail intravenous injection with CT26 cells was conducted. The oral administration doses included low dose group (5 mg/kg/day, n=10), middle dose group

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5

Chen, Ching-Chun, and 陳靜君. "Hibiscus sabdariffa Polyphenol-rich extract (HPE) via regulate CD44 signal pathway to anti-metastatic effect on human colon cancer." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13398182322361961282.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>101<br>In recent years, a natural plant extract an effective ingredient, thereby preventing or inhibiting the occurrence of cancer research has been the current trend. Roselle polyphenols Hibiscus sabdariffa Polyphenol-rich extract (HPE), one of the component in Roselle’s function, our previous studies indicate that HPE can effectively promote apoptosis on gastric cancer and colon cancer cell, the impact on tumor metastasis has not been clarified, so the next one probe into whether HPE inhibit cancer cell metastasis, and to explore the mechanism. We conducted MTT

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6

Xia, Ci-Chan, and 夏慈禪. "The Anti-metastatic Effects of Inoscavin A on Lung Cancer Cell Lines." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/62qze4.

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碩士<br>中國醫藥大學<br>中國藥學暨中藥資源學系碩士班<br>102<br>Lung cancer is the leading cause of cancer mortality, and metastasis is a primary cause of cancer death. Inoscavin A is a new compound isolated from a medicinal mushroom Inonotus sanghuang. In this study, we first observed that inoscavin A exerted a dose-dependent inhibitory effect on adhesion, migration, and invasion of the highly metastatic A549 and LLC lung cancer cell lines in the absence of cytotoxicity. These effects were associated with a decreased protein expression of MMP-2 and MMP-9 together with an increased expression of TIMP-1 and PAI-1. In

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Yen, Chih-Yung, and 嚴智勇. "The anti-metastatic effects of Ellagic acid in Human lung carcinoma A549 cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/10515450764665479813.

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碩士<br>中國醫藥大學<br>中國藥學暨中藥資源學系碩士班<br>99<br>Metastasis in cancer patients is often fatal cancer caused by one of the reasons. Metastasis of cancer cells involve multiple processes and various cytophysiological changes, including changing adhesion capability between cells and extracellular matrix (ECM) and damaging intercellular interaction. Degradation of the ECM of the basement membrane was caused by proteinases such as matrix metalloproteinases (MMPs). Among the MMPs family, MMP-2 and MMP-9 play a critical role in tumor invasion and metastasis, therefore, the inhibition of cell migration or inva

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8

Cheng-Chi, Yang, and 楊呈琦. "To study the anti-metastatic effects of clarithromycin on non-small lung cancer cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/84901574780516346840.

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碩士<br>國立中興大學<br>生命科學系<br>93<br>Abstract Clarithromycin is a new 14-member macrolide antibiotic, it has been used as anti-inflammatory drug to treat diffuse panbronchiolitis and to restraining Helicobacter Pylori since 1990. Clinically mainly in long term-low dose; in 1997, Yasunami indicated that clarithromycin is a potent angiogenesis inhibitor for anti-tumor activity, the research later indicated clarithromycin can suppress tumor-associated growth factor expression by tumor, such as TNF-α and IL-6, result in suppressed tumor growth and metastasis, but its detail mechanism is unclear. And i

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9

Chen, Yu-Ling, and 陳玉聆. "Effects on Cell Growth and Expression of Anti-metastatic Gene Drg 1 by Apigenin and Butyrate in Human Metastatic Colorectal Carcinoma Cell LoVo." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/14760677857910965608.

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碩士<br>實踐大學<br>食品營養研究所<br>92<br>Apigenin, a common plant flavonoid, has been reported as a chemopreventive agent possesses anti-oxidative and anti-carcinogenic properties. Butyrate, a short-chain fatty acid produced by microbial fermentation of fiber in the colonic lumen, has been shown to modulate proliferation and differentiation of colon cancer cell line. Drg 1 was first identified upon induction of differentiation in colon carcinoma cells. Recent studies hypothesize that drg 1 might act as a metastatic suppressor gene in colon carcinoma cell line. Based on above hypothesis, the aim of our s

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10

wang, Hsiao-Chieh, and 王曉潔. "In vitro anti-metastatic effects of hispolon on liver cancer cell line, SK-Hep-1 cell." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/08352912796774236036.

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碩士<br>中國醫藥大學<br>中國藥學研究所<br>96<br>Metastasis is one of the major causes of cancer-associated mortality, and a large number of cancerous cells have the ability to secret matrix metalloproteinases (MMPs). Among them, MMP 2 and MMP 9, an extracellular matrix enzyme, is a key enzyme for cancerous cells to invade distant tissue from in-situ tissue. Many literatures showed that Phellinus linteus (PI) inhibited the cancer proliferation and metastasis. Hispolon was a highly antioxidant compound in PI and it possessed the effect of apoptosis on human epidermoid KB cells. However, the mechanism is still

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11

"Investigation of the anti-tumor and anti-metastasis effects of selected Chinese medicines in metastatic breast cancer, and the combined use with zoledronate." 2013. http://library.cuhk.edu.hk/record=b5884437.

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Luo, Kewang.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 278-305).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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12

Lee, Chia-Hsuan, and 李佳軒. "Theasinensin A exerts anti-metastatic effects on HT-29 cells via downregulating the expression of MMP-9 and CCL2." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/33842629788152047214.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>104<br>Cancer metastasis, the terminal stage of cancer development, is accounting for approximately 90% of all human cancer mortalities. Previous research have suggested that theasinensin A (TSA) has anti-inflammatory effects; however, its potential for inhibiting colon cancer metastasis remains to be unclear. Therefore, in this research, we focused on investigating the mechanism of inhibitory effects of TSA on TPA-induced colon cancer cell migration. Previous studies report that matrix metalloproteinase-9 (MMP-9) is critical to intravasation and C-C motif ligand 2 (

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13

Chen, I.-Hua, та 陳懿華. "Studies on the anti-metastatic effects and mechanisms of action of 3,4-methylenedioxy-β-nitrostyrene in triple-negative breast cancer cells". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/gzvgez.

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博士<br>高雄醫學大學<br>天然藥物研究所博士班<br>103<br>Triple negative breast cancer (TNBC) exhibits an aggressive clinical course by high metastatic potential. It is known that integrin-mediated cell adhesion and migration are important for cancer metastasis. In the present study, a synthetic compound, 3, 4-methyenedioxy-β-nitrostyrene (MNS), significantly inhibited adhesion of TNBC cell lines to different extracellular matrix (ECM) components. The antimetastatic capacity of MNS was also observed through reducing TNBC cells migration and invasion without affecting cell viability. Confocal microscopy revealed t

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14

Chen, Huei-Yan, and 陳惠宴. "The anti-metastatic effects and mechanisms of alpha-carotene and the combination of multi-carotenoids in human hepatocarcinoma SK-Hep-1 cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/59211460638177678507.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>100<br>Cancer metastasis is a major cause of death for cancer patients, so effectively inhibited the metastasis of cancer cells can be used as one of the therapeutic strategies. alpha-Carotene is one of major carotenoids in human plasma, and is found in dark green and orange fruits and vegetables such as carrots, pumpkin, spinach and tomato. alpha-Carotene has been shown to possess anti-cancer activity both in vitro and in vivo. Epidemiological studies have indicated that elevated serum alpha-carotene concentration is associated with reduced risks of several

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15

"In vivo and in vitro investigations on the anti-metastatic effects of natural cyclopeptides RA-V and RA-XII in breast cancer and their underlying mechanisms." 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291746.

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Leung, Hoi Wing.<br>Thesis Ph.D. Chinese University of Hong Kong 2015.<br>Includes bibliographical references (leaves 321-349).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on 09, November, 2016).

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