Log in

Relevant bibliographies by topics / Anti-metastatic effect / Journal articles

To see the other types of publications on this topic, follow the link: Anti-metastatic effect.

Journal articles on the topic 'Anti-metastatic effect'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Anti-metastatic effect.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Delgado, Yamixa, Anamaris Torres-Sanchez, Daraishka Perez, et al. "Deferasirox’s Anti-Chemoresistance and Anti-Metastatic Effect on Non-Small Cell Lung Carcinoma." Biomedicines 12, no. 10 (2024): 2272. http://dx.doi.org/10.3390/biomedicines12102272.

Full text

Abstract:

Clinically approved iron chelators, originally designed to address iron overload disorders, have emerged as potential anticancer agents. Deferasirox (Def), a tridentate iron chelator, has demonstrated antiproliferative effects in cancer. Background/Objectives: This study aims to elucidate the mechanism of action of Def and its impact on non-small cell lung carcinoma (NSCLC). Methods: NSCLC A549 cells were treated with Def to assess cytotoxicity, the effect on nuclear and mitochondrial pathways, and iron-containing proteins and genes to evaluate anti-metastasis and chemoresistance. A lung carci

APA, Harvard, Vancouver, ISO, and other styles

2

Mun, Jeong-Geon, Yo-Han Han, Hee-Dong Jeon, et al. "Inhibitory Effect of Gallotannin on Lung Metastasis of Metastatic Colorectal Cancer Cells by Inducing Apoptosis, Cell Cycle Arrest and Autophagy." American Journal of Chinese Medicine 49, no. 06 (2021): 1535–55. http://dx.doi.org/10.1142/s0192415x21500725.

Full text

Abstract:

Colorectal cancer (CRC) is the second most common cause of cancer death in the world, and metastatic CRC is a major cause of cancer death. Gallotannin (GT), a polyphenolic compound, has shown various biological effects such as anti-oxidant, anti-inflammatory, antimicrobial, and antitumor effects. However, the effects of GT on metastatic CRC cells are not completely understood. This study aimed to investigate the anti-metastatic effect of GT and the underlying mechanisms on metastatic CRC cells. Oral administration of GT suppressed the lung metastasis of metastatic CRC cells in the experimental

APA, Harvard, Vancouver, ISO, and other styles

3

Niu, Ying-Cai, Ji-Cheng Liu, Xue-Mei Zhao, and Jun Cao. "A Low Molecular Weight Polysaccharide Isolated from Agaricus blazei Murill (LMPAB) Exhibits Its Anti-Metastatic Effect by Down-Regulating Metalloproteinase-9 and Up-Regulating Nm23-H1." American Journal of Chinese Medicine 37, no. 05 (2009): 909–21. http://dx.doi.org/10.1142/s0192415x09007351.

Full text

Abstract:

The components of Agaricus blazei Murill (AbM) have been shown to possess antitumor potentials. Herein, we attempted to explore the anti-metastatic effect and underlying mechanism of a low molecular weight polysaccharide isolated from AbM (LMPAB). Matrigel invasion assay was applied to evaluate the effect of LMPAB on migration of BEL-7402 hepatic cancer cells in vitro. In vivo, the anti-metastatic effect of LMPAB was investigated in mouse B16 melanoma and a double-grafted SW180 tumor models. mRNA and protein levels of metalloproteinase-9 (MMP-9) or nm23-H1 upon LMPAB treatment were detected by

APA, Harvard, Vancouver, ISO, and other styles

4

Chai, Yuxia, Jizhong Xu, and Baojun Yan. "The anti-metastatic effect of baicalein on colorectal cancer." Oncology Reports 37, no. 4 (2017): 2317–23. http://dx.doi.org/10.3892/or.2017.5437.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Han, Yo-Han, Jeong-Geon Mun, Hee Dong Jeon, Ji-Ye Kee, and Seung-Heon Hong. "Betulin Inhibits Lung Metastasis by Inducing Cell Cycle Arrest, Autophagy, and Apoptosis of Metastatic Colorectal Cancer Cells." Nutrients 12, no. 1 (2019): 66. http://dx.doi.org/10.3390/nu12010066.

Full text

Abstract:

Background: Colorectal cancer (CRC) is one of the diseases with high prevalence and mortality worldwide. In particular, metastatic CRC shows low probability of surgery and lacks proper treatment. In this study, we conducted experiments to investigate the inhibitory effect of betulin against metastatic CRC and related mechanisms. Methods: Water-soluble tetrazolium assay was used to determine the effect of betulin on metastatic CRC cell viability. Flow cytometry and TUNEL assay were performed to confirm whether betulin can induce apoptosis, autophagy, and cell cycle arrest. A lung metastasis mou

APA, Harvard, Vancouver, ISO, and other styles

6

Tamaki, T., M. Iwakawa, T. Ohno, et al. "Anti-Metastatic Effect of Local Carbon-Ion Irradiation in a Highly Metastatic Mouse Model." International Journal of Radiation Oncology*Biology*Physics 69, no. 3 (2007): S613. http://dx.doi.org/10.1016/j.ijrobp.2007.07.1927.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Tanriover, Gamze, Sayra Dilmac, and Nuray Erin. "Melatonin Does Not Alter Cell Proliferation in Metastatic Breast Cancer Cells." Proceedings 2, no. 25 (2018): 1567. http://dx.doi.org/10.3390/proceedings2251567.

Full text

Abstract:

Breast cancer treatments continue to be investigated with supported by new treatment methods. Melatonin is a hormone that can be effective in the treatment of breast cancer due to its anti-oxidant effect. Melatonin had previously shown to inhibit proliferation of cancer cells. In this study, we aimed to determine the effect of melatonin on the proliferation of metastatic breast cancer cells in comparison to doxorubicin, a well-known chemotherapeutic agent. Doxorubicin inhibited proliferation of metastatic breast cancer cells while melatonin has no effect. We are currently examining the effects

APA, Harvard, Vancouver, ISO, and other styles

8

De, Debapriya, Priyanka Chowdhury, Sujogya Kumar Panda та Utpal Ghosh. "Leaf Extract and Active Fractions of Dillenia pentagyna Roxb. Reduce In Vitro Human Cancer Cell Migration Via NF-κB Pathway". Integrative Cancer Therapies 21 (січень 2022): 153473542211288. http://dx.doi.org/10.1177/15347354221128832.

Full text

Abstract:

Background: Different parts of Dillenia pentagyna have long been used in traditional medicines to cure several diseases including cancer. However, the mechanism(s) of anti-cancer effects are still unknown. We aimed to elucidate the anti-metastatic potential of ethanolic extracts of leaves of D. pentagyna (EELDP) and active fractions of it in highly metastatic human cancer cells. Methods: We screened different HPLC fractions of EELDP based on their anti-metastatic effect. We used TLC and ESI-MS for determining the presence of various phytochemicals in EELDP and fractions. We monitored in vitro

APA, Harvard, Vancouver, ISO, and other styles

9

Karsch-Bluman, Adi, Shimrit Avraham, Miri Assayag, Ouri Schwob, and Ofra Benny. "Encapsulated Carbenoxolone Reduces Lung Metastases." Cancers 11, no. 9 (2019): 1383. http://dx.doi.org/10.3390/cancers11091383.

Full text

Abstract:

Carbenoxolone is an anti-inflammatory compound and a derivate of a natural substance from the licorice plant. We previously showed that carbenoxolone reduces the metastatic burden in the lungs of mice through its antagonistic effect on high mobility group box 1 (HMGB1). To further enhance carbenoxolone’s activity and localization in the lungs, thereby reducing the potential adverse side effects resulting from systemic exposure, we developed a poly(lactic-co-glycolic acid) (PLGA) slow-release system for pulmonary delivery which maintains drug activity in-vitro, as demonstrated in the anoikis as

APA, Harvard, Vancouver, ISO, and other styles

10

Muflikhasari, Haruma Anggraini, Riris Istighfari Jenie, Ratna Asmah Susidarti, and Edy Meiyanto. "Growth Inhibitory Property of Pentagamavunone-0 (PGV-0) on 4T1 Cells under Stress Condition : 2D and 3D Culture Model." Indonesian Journal of Cancer Chemoprevention 10, no. 3 (2019): 149. http://dx.doi.org/10.14499/indonesianjcanchemoprev10iss3pp149-158.

Full text

Abstract:

Pentagamavunone-0 (PGV-0), one of the curcumin analogue, is reported to have a cytotoxic effect on various cancer cells. This study aimed to explore the growth inhibitory effects of PGV-0 against highly-metastatic breast cancer, 4T1 cells under stress condition covering 2D and 3D speroid cytotoxic, anti-migration, and suppression of MMP-9. PGV-0 showed cytotoxic effects on 2D and 3D 4T1 cells with IC50value of 49 μM and 26 μM, respectively. In addition, PGV-0 performed anti-migratory effect. The single treatment at 25 μM PGV-0 and 50 μM showed inhibitory effect on cell migration by 54% and 51%

APA, Harvard, Vancouver, ISO, and other styles

11

ZHAO, GAIPING, ERYUN CHEN, XIAOLI YU, HAIPO CUI, JIE LV, and JIE WU. "THREE-DIMENSIONAL MODEL OF METASTATIC TUMOR ANGIOGENESIS IN RESPONSE TO ANTI-ANGIOGENIC FACTOR ANGIOSTATIN." Journal of Mechanics in Medicine and Biology 17, no. 06 (2017): 1750094. http://dx.doi.org/10.1142/s0219519417500944.

Full text

Abstract:

Surgeons observed that primary tumors are capable of suppressing the growth of their metastases by generating anti-angiogenic factor angiostatin. A three-dimensional (3D) mathematical model of development of the metastatic tumor vasculature is presented to simulate the morphology and construction of 3D microvascular networks under the inhibitory effect of anti-angiogenic factor angiostatin excreted by the primary tumor. The simulation results demonstrate that metastatic tumor microvascular density (MVD) decreases by about 60%, 58% and 52%, respectively, at [Formula: see text], 7 and 14 days un

APA, Harvard, Vancouver, ISO, and other styles

12

Ozer, Janet, Daniel Fishman, Brit Eilam, Avi Golan-Goldhirsh, and Jacob Gopas. "Anti-Metastatic Effect of Semi-Purified Nuphar Lutea Leaf Extracts." Journal of Cancer 8, no. 8 (2017): 1433–40. http://dx.doi.org/10.7150/jca.18435.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Movahhed, Morteza, Mona pazhouhi, HadiEsmaeili Gouvarchin Ghaleh, and BahmanJalali Kondori. "Anti-metastatic effect of taraxasterol on prostate cancer cell lines." Research in Pharmaceutical Sciences 18, no. 4 (2023): 439. http://dx.doi.org/10.4103/1735-5362.378090.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Gupta, Nehal, and Sanjay K. Srivastava. "Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis." Pharmaceuticals 14, no. 6 (2021): 521. http://dx.doi.org/10.3390/ph14060521.

Full text

Abstract:

Triple-negative breast cancer (TNBC) is considered to be the most aggressive and malignant neoplasm and is highly metastatic in nature. In the current study, we investigated the anti-metastatic potential of atovaquone, a protozoal drug prescribed for Pneumocystis pneumonia. We showed that atovaquone induced apoptosis and reduced the survival of several aggressive metastatic TNBC cell lines including metastatic patient-derived cells by reducing the expression of integrin α6, integrin β4, FAK, Src, and Vimentin. In order to study the efficacy of atovaquone in suppressing metastasized breast tumo

APA, Harvard, Vancouver, ISO, and other styles

15

de Souza Queiroz, Karla Cristiana, Willian Fernando Zambuzzi, Ana Carolina Santos de Souza, et al. "A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours." Cancer Letters 258, no. 1 (2007): 126–34. http://dx.doi.org/10.1016/j.canlet.2007.08.024.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Ertanto, Yogi, Rohmad Yudi Utomo, Riris Istighfari Jenie, Ratna Asmah Susidarti, and Edy Meiyanto. "Anti-metastatic effect of curcumin analog pentagamaboronon-0-fructose (PGB-0-F) against 4T1 breast cancer cells." Indonesian Journal of Biotechnology 23, no. 2 (2018): 109. http://dx.doi.org/10.22146/ijbiotech.36431.

Full text

Abstract:

Development of a chemotherapeutic agent and boron carrying pharmaceutical based on triple-negative breast cancer is important due to its metastatic progression. Metastases are often more dangerous than the primary tumor and they are responsible for 90% of all cancer deaths. The purpose of this study was to explore the anti-metastatic activities of the PGB-0 complex with fructose (PGB-0-F) against 4T1 breast cancer cells. A scratch wound healing assay was carried out to determine the migration inhibition ability of PGB-0-F, while MMP-9 expression was analysed using gelatin zymography. The testi

APA, Harvard, Vancouver, ISO, and other styles

17

Masuda, Chinami, Mamiko Morinaga, Daiko Wakita, et al. "PD-L1 blockade exhibits anti-tumor effect on brain metastasis by activating CD8+ T cells in hematogenous metastasis model with lymphocyte infusion." Clinical & Experimental Metastasis 39, no. 2 (2021): 335–44. http://dx.doi.org/10.1007/s10585-021-10135-6.

Full text

Abstract:

AbstractBrain metastases are common complication in cancer patients. Immune checkpoint inhibitors show therapeutic benefits also in patients with central nervous system (CNS) metastases. However, their antitumor effects on metastatic tumors and their underlying mechanisms are still poorly understood. In this study we investigated the antitumor effect of anti-programmed death-ligand 1 (PD-L1) antibody on metastatic brain tumors and evaluated immune responses during treatment. We employed a hematogenous brain metastasis xenograft model using immunodeficient mice with murine lymphocyte infusions.

APA, Harvard, Vancouver, ISO, and other styles

18

Chanvorachote, Pithi, Akkarawut Kowitdamrong, Thidarat Ruanghirun, Boonchoo Sritularak, Chutichot Mungmee, and Kittisak Likhitwitayawuid. "Anti-metastatic Activities of Bibenzyls from Dendrobium pulchellum." Natural Product Communications 8, no. 1 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800127.

Full text

Abstract:

Our investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an important new approach for cancer drug development.

APA, Harvard, Vancouver, ISO, and other styles

19

Meiyanto, Edy, Herwandhani Putri, Yonika Arum Larasati, et al. "Anti-proliferative and Anti-metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (PGV-1), Toward Highly Metastatic Breast Cancer Cells in Correlation with ROS Generation." Advanced Pharmaceutical Bulletin 9, no. 3 (2019): 445–52. http://dx.doi.org/10.15171/apb.2019.053.

Full text

Abstract:

Purpose: Pentagamavunon-1 (PGV-1) is a curcumin analogue that shows cytotoxic activity in various cancer cells. In this study, we evaluated the effect of PGV-1 on a highly metastatic breast cancer cell line, the 4T1 cells, as an anti-metastatic and anti-proliferative agent. Methods: Cell viability was evaluated using MTT assay; while cell cycle profile, apoptosis incidence, and ROS intracellular level were determined by flow cytometry. Cell senescence was observed under senescence-associated-β-galactosidase (SA-β-gal) staining assay. The expression of matrixmetalloproteinase-9 (MMP-9) was dete

APA, Harvard, Vancouver, ISO, and other styles

20

Phan, Thi Kieu Trang, Fahimeh Shahbazzadeh, Thi Thu Huong Pham, and Takanori Kihara. "Alpha-mangostin inhibits the migration and invasion of A549 lung cancer cells." PeerJ 6 (June 25, 2018): e5027. http://dx.doi.org/10.7717/peerj.5027.

Full text

Abstract:

Several studies have indicated that α-mangostin exerts anti-metastasis and anti-subsistence effects on several types of cancer cells. Especially, the anti-metastatic effect of α-mangostin on cancer cells is a prospective function in cancer treatment. However, the metastasis process is complicated, and includes migration, invasion, intravasation, and extravasation; thus, the main target of anti-metastatic effect of α-mangostin is not known. In this study, we investigated the effects of α-mangostin on the invasion, subsistence, and migration of lung cancer cells under co-culture conditions with

APA, Harvard, Vancouver, ISO, and other styles

21

Jang, Bian, Li Xu, Madhappan S. Moorthy, et al. "Lipopolysaccharide-coated CuS nanoparticles promoted anti-cancer and anti-metastatic effect by immuno-photothermal therapy." Oncotarget 8, no. 62 (2017): 105584–95. http://dx.doi.org/10.18632/oncotarget.22331.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Kim, Young Min, Min Jeong Ku, Young-Jin Son, Jung-Mi Yun, Seong Hwan Kim, and Sang Yeol Lee. "Anti-metastatic effect of cantharidin in A549 human lung cancer cells." Archives of Pharmacal Research 36, no. 4 (2013): 479–84. http://dx.doi.org/10.1007/s12272-013-0044-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Li, Dan-dan, Ying Wang, Ju Zhiran, Eun-La Kim, Jongki Hong та Jee H. Jung. "Anti-metastatic Effect of Natural Product-motivated Synthetic PPAR-γ Ligands". Natural Product Sciences 28, № 2 (2022): 80–95. http://dx.doi.org/10.20307/nps.2022.28.2.80.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Nowak, Ewa, Daniel Sypniewski, and Ilona Bednarek. "Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies." Molecular Biology Reports 47, no. 3 (2020): 1965–78. http://dx.doi.org/10.1007/s11033-020-05293-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Hundsberger, Harald, Anna Stierschneider, Victoria Sarne, et al. "Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models." Molecules 26, no. 3 (2021): 717. http://dx.doi.org/10.3390/molecules26030717.

Full text

Abstract:

Quercetin, a dietary flavonoid found in fruits and vegetables, has been described as a substance with many anti-cancer properties in a variety of preclinical investigations. In the present study, we demonstrate that 2D and 3D melanoma models exhibit not only different sensitivities to quercetin, but also opposite, cancer-promoting effects when metastatic melanoma spheroids are treated with quercetin. Higher concentrations of quercetin reduce melanoma growth in three tested cell lines, whereas low concentrations induce the opposite effect in metastatic melanoma spheroids but not in the non-meta

APA, Harvard, Vancouver, ISO, and other styles

26

Van Buren, George, Anthony D. Yang, Nikolaos A. Dallas, et al. "Effect of Molecular Therapeutics on Liver Regeneration in a Murine Model." Journal of Clinical Oncology 26, no. 11 (2008): 1836–42. http://dx.doi.org/10.1200/jco.2007.11.6566.

Full text

Abstract:

Purpose Unresectable metastatic colorectal cancer (CRC) can be rendered resectable with systemic chemotherapy in approximately 20% of cases. Most patients with metastatic CRC receive chemotherapy with the addition of targeted therapy with anti–vascular endothelial growth factor (VEGF) or anti–epidermal growth factor receptor (EGFR) antibodies. We sought to determine whether anti-VEGF receptor (VEGFR) or anti-EGFR therapy would impair liver regeneration after partial hepatectomy (PH) in mice. Materials and Methods Mice underwent either 66% PH or sham laparotomy. In the first experiment, mice in

APA, Harvard, Vancouver, ISO, and other styles

27

Yi, Xiaoli, Yue Yan, Xinran Shen, Lian Li, and Yuan Huang. "Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression." Pharmaceutics 14, no. 8 (2022): 1534. http://dx.doi.org/10.3390/pharmaceutics14081534.

Full text

Abstract:

Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic tumors due to their vital roles in providing energy supply, upregulating pro-metastatic factors, and controlling cell-death signaling. Thus, selectively delivering CPT to mitochondria appears to be a feasible way of improving the anti-metastasis effect and reducing adverse effects. Here, we established a 2-(dimethylamino) ethyl methacrylate (DEA)-modified N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer–CP

APA, Harvard, Vancouver, ISO, and other styles

28

Lestari, Beni, Laeli Muntafiah, Ziana Walidah, and Riris Istighfari Jenie. "A Comparison of Antimetastatic Activity between Nerium indicum and Cinnamomum burmannii on 4T1 Cells." Indonesian Journal of Cancer Chemoprevention 8, no. 2 (2017): 85. http://dx.doi.org/10.14499/indonesianjcanchemoprev8iss2pp85-93.

Full text

Abstract:

Metastatic process becomes a major problem in advanced cancer cases. Natural compounds found in several plants in Indonesia have a potency to be developed as chemoterapeutic agent which are targeted to metastatic process. Jure leaves (Nerium indicum) which contain oleandrin and cinnamaldehyde in cinnamon bark (Cinnamomum burmannii) reported to have cytotoxic activity on several cancer cells, but their activities on metastasic process have never been explored. This research aims to reveal and to compare their anti-metastatic effect toward 4T1 breast cancer cells. The cytotoxicity of jure leaves

APA, Harvard, Vancouver, ISO, and other styles

29

Wall, Thomas P., Peter D. Crowley, Aislinn Sherwin, Andrew G. Foley, and Donal J. Buggy. "Effects of Lidocaine and Src Inhibition on Metastasis in a Murine Model of Breast Cancer Surgery." Cancers 11, no. 10 (2019): 1414. http://dx.doi.org/10.3390/cancers11101414.

Full text

Abstract:

Breast cancer recurs in 20% of patients following intended curative resection. In vitro data indicates that amide local anaesthetics, including lidocaine, inhibit cancer cell metastasis by inhibiting the tyrosine kinase enzyme Src. In a murine breast cancer surgery model, systemic lidocaine reduces postoperative pulmonary metastases. We investigated whether the additional administration of bosutinib (a known Src inhibitor) influences lidocaine’s observed beneficial effect in this in vivo model. Female BALB/c mice (n = 95) were inoculated with 25,000 4T1 cells into the mammary fad pad and after

APA, Harvard, Vancouver, ISO, and other styles

30

Chang, Kou-Hwa, Hui-Fen Liao, Hen-Hong Chang, et al. "Inhibitory Effect of Tetrandrine on Pulmonary Metastases in CT26 Colorectal Adenocarcinoma–Bearing BALB/c Mice." American Journal of Chinese Medicine 32, no. 06 (2004): 863–72. http://dx.doi.org/10.1142/s0192415x04002478.

Full text

Abstract:

Tumor metastasis is a major cause of mortality in cancer patients. The anti-metastatic effect of tetrandrine, an alkaloid isolated from Stephania tetrandrae S. Moore, was investigated in a pulmonary metastatic model of colorectal cancer-bearing mice. Tetrandrine decreased the viability of murine colorectal adenocarcinoma CT26 cells in a time- and dose-dependent manner. CT26 cells were injected into BALB/c mice via a tail vein to establish pulmonary metastases. After this, the mice were given intraperitoneal injections of tetrandrine (10 mg/kg/day), 5-fluorouracil (5-FU) at the same dose, or ve

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Kangli, Lingchen Tao, Meifei Zhu, et al. "Melittin Inhibits Colorectal Cancer Growth and Metastasis by Ac-Tivating the Mitochondrial Apoptotic Pathway and Suppressing Epithelial–Mesenchymal Transition and Angiogenesis." International Journal of Molecular Sciences 25, no. 21 (2024): 11686. http://dx.doi.org/10.3390/ijms252111686.

Full text

Abstract:

Melittin has previously been found to have a positive effect on colorectal cancer (CRC) treatment, one of the most difficult-to-treat malignancies, but the mechanism by which this effect occurs remains unclear. We evaluated melittin’s pro-apoptotic and anti-metastatic effects on CRC in vitro and in vivo. The results showed that melittin-induced mitochondrial ROS bursts decreased ΔΨm, inhibited Bcl-2 expression, and increased Bax expression in both cells and tumor tissues. This led to increased mitochondrial membrane permeability and the release of pro-apoptotic factors, particularly the high e

APA, Harvard, Vancouver, ISO, and other styles

32

Youssef, Touimri, Taleb Imad, Tadlaoui Abderrahman, Toreis Mehdi, Bazine Aziz, and Fetouhi Mohammed. "Double HER2 Blockade and Iatrogenic Hypothyroidism During Treatment of HER2-Positive Metastatic Breast Cancer: A Clinical Case and Literature Review." EAS Journal of Medicine and Surgery 7, no. 05 (2025): 86–89. https://doi.org/10.36349/easjms.2025.v07i05.006.

Full text

Abstract:

HER2-positive metastatic breast cancer represents a significant therapeutic challenge. Its prognosis has been altered thanks to significant advances in targeted anti-HER2 therapies. These treatments, such as trastuzumab and pertuzumab, have significantly improved the management of this pathology, enhancing patient survival, but are also responsible for adverse effects. Hypothyroidism, although less frequent than other complications, is an important side effect to recognize and manage. This clinical case presents a 47-year-old patient with HER2-positive metastatic breast cancer treated with che

APA, Harvard, Vancouver, ISO, and other styles

33

Rodriguez-Vida, Alejo, Diletta Bianchini, Simon Hughes, et al. "Is there an anti-androgen withdrawal effect with enzalutamide?" Journal of Clinical Oncology 32, no. 4_suppl (2014): 200. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.200.

Full text

Abstract:

200 Background: The second generation anti-androgen enzalutamide has demonstrated improved survival in patients with metastatic castration-resistant prostate cancer (CRPC) progressing after docetaxel. While an anti-androgen withdrawal effect has been reported for bicalutamide, flutamide, and other non-steroidal and steroidal anti-androgens, there is no published evidence of any withdrawal effect with enzalutamide. Methods: We retrospectively identified 30 consecutive patients with advanced prostate cancer who were treated with enzalutamide post-docetaxel at three London hospitals. All patients

APA, Harvard, Vancouver, ISO, and other styles

34

Nie, Run-Cong, Shu-Qiang Yuan, Yuanfang Li, Yingbo Chen, and Zhiwei Zhou. "Surrogate endpoints for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials of advanced melanoma." Journal of Clinical Oncology 38, no. 15_suppl (2020): 10030. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.10030.

Full text

Abstract:

10030 Background: The mechanisms of action of anti-PD-1/PD-L1 agents are markedly distinct from those of cytotoxic agents, thus a critical issue that is under investigation is what is the optimal endpoint and how should tumor response be evaluated in anti-PD-1/PD-L1 trials for metastatic melanoma. Here, we assessed surrogacy of objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) for overall survival (OS) in anti-PD-1/PD-L1 trials of metastatic melanoma through a meta-analysis of randomized controlled trials (RCTs). Methods: PubMed and EMBASE were searc

APA, Harvard, Vancouver, ISO, and other styles

35

Garrido, Greta, Pablo Lorenzano, Belinda Sánchez, et al. "T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies." Cancer Immunology, Immunotherapy 56, no. 11 (2007): 1701–10. http://dx.doi.org/10.1007/s00262-007-0313-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Zong, Aizhen, Yuhong Liu, Yan Zhang, et al. "Anti-tumor activity and the mechanism of SIP-S: A sulfated polysaccharide with anti-metastatic effect." Carbohydrate Polymers 129 (September 2015): 50–54. http://dx.doi.org/10.1016/j.carbpol.2015.04.017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Lee, Jiyun, and Yeon Hee Park. "Trastuzumab deruxtecan for HER2+ advanced breast cancer." Future Oncology 18, no. 1 (2022): 7–19. http://dx.doi.org/10.2217/fon-2021-0550.

Full text

Abstract:

Trastuzumab deruxtecan (T-DXd, DS-8201), an anti-HER2 antibody–drug conjugate, has shown significant clinical benefits in HER2+ metastatic breast cancer patients. In the phase 2 DESTINY-Breast01 trial, T-DXd demonstrated an objective response of 60.9% and median progression-free survival of 16.4 months, laying the foundation for accelerated approval in HER2+ metastatic breast cancer patients who have received two or more prior anti-HER2-based regimens in the metastatic setting. Moreover, T-DXd exhibited promising antitumor efficacy against HER2-low-expressing metastatic breast cancer. Its dist

APA, Harvard, Vancouver, ISO, and other styles

38

Byrgazov, Konstantin, Claes Anderson, Benjamin Salzer, et al. "Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592093789. http://dx.doi.org/10.1177/1758835920937891.

Full text

Abstract:

Background: Low survival rates in metastatic high-grade osteosarcoma (HGOS) have remained stagnant for the last three decades. This study aims to investigate the role of aminopeptidase N (ANPEP) in HGOS progression and its targeting with a novel lipophilic peptidase-enhanced cytotoxic compound melphalan flufenamide (melflufen) in HGOS. Methods: Meta-analysis of publicly available gene expression datasets was performed to determine the impact of ANPEP gene expression on metastasis-free survival of HGOS patients. The efficacy of standard-of-care anti-neoplastic drugs and a lipophilic peptidase-e

APA, Harvard, Vancouver, ISO, and other styles

39

Al-Qadi, Nasreen, Alan Halim, Hussein Mackie, Lorenzo Sempere, and Anna Moore. "Exploring the effects of inhibiting miR-10b on breast cancer stemness and metastasis." Journal of Clinical Oncology 41, no. 16_suppl (2023): e13084-e13084. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e13084.

Full text

Abstract:

e13084 Background: There are currently limited effective therapeutic options for metastatic breast cancer, and none target the metastatic process. MiR-10b is a major driver of breast cancer cell invasion and migration. Our lab has demonstrated its importance in metastatic cell viability, positioning miR-10b as a target for metastatic breast cancer. Our previous studies demonstrated that delivery of a novel therapeutic consisting of antisense anti-miR-10b oligomers conjugated to magnetic nanoparticles (termed MN-anti-miR10b) prevented metastases in vivo. These studies led us to hypothesize that

APA, Harvard, Vancouver, ISO, and other styles

40

Shim, Bum-Sang, Kun-Koo Park, and Seung-Hoon Choi. "Anti-metastatic Effects of Fuzhengfangaitang on Human Fibrosarcoma Cells HT1080." American Journal of Chinese Medicine 31, no. 02 (2003): 235–46. http://dx.doi.org/10.1142/s0192415x03000953.

Full text

Abstract:

Fuzhengfangaitang (FZFAT) is used to inhibit recurrence and metastasis of cancer in the clinic. By applying an in vitro invasion assay model, we examined the antimetastatic effect of FZFAT. In the 3H-thymidine incorporation assay, FZFAT-treated groups showed a decreased DNA synthesis rate compared with the control group (F-value 87.42981, P-value 2.02E-08, F0.05(3,12) 3.4903). Gelatin zymogram assay showed that FZFAT decreased the gelatinolytic activity of matrix metalloproteinases-9 (MMP-9) from human fibrosarcoma cell line (HT-1080), at concentrations of 200 and 400 μg/ml. In the MMPs dot bl

APA, Harvard, Vancouver, ISO, and other styles

41

Lim, Yoojoo, Sae-Won Han, Jeong Hee Yoon, et al. "Clinical Implication of Anti-Angiogenic Effect of Regorafenib in Metastatic Colorectal Cancer." PLOS ONE 10, no. 12 (2015): e0145004. http://dx.doi.org/10.1371/journal.pone.0145004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Lin, Chuan-Yi, May-Hua Liao, Chi-Yu Yang, et al. "Anti-Metastatic Activity of Tagitinin C from Tithonia diversifolia in a Xenograft Mouse Model of Hepatocellular Carcinoma." Livers 2, no. 4 (2022): 400–411. http://dx.doi.org/10.3390/livers2040030.

Full text

Abstract:

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of tagitinin C in xenograft models of hepatocellular carcinoma (HCC). We isolated tagitinin C from a methanolic extract of the leaves of T. diversifolia. HepG-2 and Huh 7 hepatoma cells were treated with tagitinin C, and cell viability, migration, and matrix metalloproteinase (MPP) activity were assessed using the 3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide assay, scratch migration assay, and MMP activit

APA, Harvard, Vancouver, ISO, and other styles

43

Stravokefalou, Vasiliki, Dimitris Stellas, Sevasti Karaliota, et al. "Abstract 2441: hetIL-15 decreases tumor cell dissemination and colonization and synergizes with chemotherapy and surgery to cure murine 4T1 breast tumors." Cancer Research 82, no. 12_Supplement (2022): 2441. http://dx.doi.org/10.1158/1538-7445.am2022-2441.

Full text

Abstract:

Abstract Introduction: Metastasis is responsible for most of the cancer-related deaths (~ 90%). Metastatic triple negative breast cancer (TNBC) has poor survival and chemotherapy pre- and post-surgery has been the standard treatment for decades. Polymorphonuclear - myeloid derived suppressor cells (PMN-MDSCs) are implicated in the process of metastasis. IL-15 stimulates the proliferation and cytolytic activity of CD8+T cells and Natural Killer cells (NKs) and has been reported to have anti-metastatic activity. We have produced the native heterodimeric form of IL-15 (hetIL-15) which has advance

APA, Harvard, Vancouver, ISO, and other styles

44

Małek, Anna, Marek Wojnicki, Aleksandra Borkowska, et al. "Gold Nanoparticles Inhibit Extravasation of Canine Osteosarcoma Cells in the Ex Ovo Chicken Embryo Chorioallantoic Membrane Model." International Journal of Molecular Sciences 24, no. 12 (2023): 9858. http://dx.doi.org/10.3390/ijms24129858.

Full text

Abstract:

Canine osteosarcoma (OS) is an aggressive bone tumor with high metastatic potential and poor prognosis, mainly due to metastatic disease. Nanomedicine-based agents can be used to improve both primary and metastatic tumor treatment. Recently, gold nanoparticles were shown to inhibit different stages of the metastatic cascade in various human cancers. Here, we assessed the potential inhibitory effect of the glutathione-stabilized gold nanoparticles (Au-GSH NPs) on canine OS cells extravasation, utilizing the ex ovo chick embryo chorioallantoic membrane (CAM) model. The calculation of cells extra

APA, Harvard, Vancouver, ISO, and other styles

45

Ozkan, Metin, Ender Dogan, Mahmut Ucar, et al. "Effect of tumor location in metastatic colorectal cancer to response anti-EGFR and anti-VEGF treatment: One center study." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15023-e15023. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15023.

Full text

Abstract:

e15023 Background: Colorectal cancer is the one of the most common malignancy in western countries. In addition to standart treatment antiEGFR and antiVEGF agents have improved PFS and overall survival. Current studies showed that the colorectal cancers have heterogenous characteristics. The Colon is divided into two parts as a right and left colon according to embrological origin. Recent years supposed that right and left located colorectal tumors may not response samely to anti egfr and anti vegfr therapies. We performed a retrospective study in our clinic to answer this questions. Methods:

APA, Harvard, Vancouver, ISO, and other styles

46

Venegas, Diego, Elia Neninger, Carlos Iberico, et al. "Response to epidermal growth factor vaccine in patients with metastatic non-small cell lung cancer (NSCLC) after progressing to first-line therapy." Journal of Clinical Oncology 30, no. 15_suppl (2012): 2531. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.2531.

Full text

Abstract:

2531 Background: A direct correlation between anti–epidermal growth factor (EGF)antibody titers and survival was demonstrated in vaccinated patients with novel NSCLC advanced in Phase II studies. We show the results of treatment with anti-EGF vaccine in a cohort of patients with metastatic NSCLC after progressing to first line therapy. We evaluated immunogenicity, safety, treatment response and effect on survival. Methods: 12 patients with metastatic NSCLC after progressing to first-line therapy received anti EGF-vaccine alone or in combination with chemotherapy. Results: From October 2009 unt

APA, Harvard, Vancouver, ISO, and other styles

47

Weizman, Orr-El, Irina Krykbaeva, Marcus Bosenburg, and Akiko Iwasaki. "Conventional type 2 dendritic cells and natural killer cells mediate control of early metastatic seeding." Journal of Immunology 204, no. 1_Supplement (2020): 88.17. http://dx.doi.org/10.4049/jimmunol.204.supp.88.17.

Full text

Abstract:

Abstract The multistep progression of transformed primary tumors to metastatic dissemination and seeding of distant site is a lethal determinant of disease. Although the role of immune cells and immune sensors in promoting or restricting metastatic growth is well described, whether immune cells are capable of detecting and controlling metastatic cells during peripheral tissue seeding is unknown. Here we examine if local immune cells can confer early anti-metastatic control in the lung using intracardiac injection to mimic metastatic spread. Using a syngeneic mouse model of YUMMER1.7 melanoma e

APA, Harvard, Vancouver, ISO, and other styles

48

Chandni, Patel, Rebecca Murerwa, Thomas Amuti, and Innocent Ouko. "Anticancer and anti-metastatic effects of metformin in cervical cancer: A narrative review." Journal of Obstetrics and Gynaecology of Eastern and Central Africa 33, no. 5 (2021): 180–87. http://dx.doi.org/10.59692/jogeca.v33i5.467.

Full text

Abstract:

Background: Cervical cancer is a significant cause of maternal morbidity and mortality despite concerted efforts towards its prevention. The high disease burden is attributed to the high prevalence of HIV, high treatment costs, and inaccessibility to treatment, particularly in developing countries. Multiple interventions, including metformin therapy, have been proposed for cervical cancer management. Metformin is a standard antidiabetic drug. In vitro studies have demonstrated mechanisms through which it can disrupt cervical cancer pathogenesis.Objective: To review the literature on metformin’

APA, Harvard, Vancouver, ISO, and other styles

49

Yang, Dianwen. "Development of Anti-metastatic Drugs Based on Banned Imide-Polyamine Conjugates and Their Application in The Treatment of Liver Cancer." Academic Journal of Science and Technology 9, no. 2 (2024): 261–65. http://dx.doi.org/10.54097/jzqhd089.

Full text

Abstract:

The purpose of this study was to develop an anti-metastasis drug based on a banned imide-polyamine conjugate and to explore its application in the treatment of liver cancer. First, we designed and synthesized a series of forbidden imide-polyamine conjugates and evaluated their inhibitory effects on the migration and invasion capacity of HCC cells by cell assay. The results showed that these compounds were able to significantly reduce the metastatic ability of HCC cells. Further mechanistic studies revealed that these compounds are able to inhibit the metastasis of HCC cells by interfering with

APA, Harvard, Vancouver, ISO, and other styles

50

Bitla, Shreeja Srinivas, and Gnanasekar Munirathinam. "Abstract 4975: Anti-cancer effect of a probiotic bacteria-derived compound, 1,4-Dihydroxy-2-naphthoic acid in prostate cancer." Cancer Research 83, no. 7_Supplement (2023): 4975. http://dx.doi.org/10.1158/1538-7445.am2023-4975.

Full text

Abstract:

Abstract Cancer incidence has been increasing globally and the major cause for mortality associated with this disease is due to metastasis development. Followed by skin and lung cancer, prostate cancer (PCa) is one of the most common cancers prevailing among older men in the United States. Although androgen deprivation therapy (ADT) is the mainstay treatment for PCa, most patients undergoing ADT eventually develop metastatic PCa. Moreover, other treatment options, such as chemotherapy and radiotherapy, have toxic side effects and are ineffective in controlling advanced PCa. Hence, there arises

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!