Relevant bibliographies by topics / Anti-Parkinson

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Anti-Parkinson'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Anti-Parkinson"

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Chalorak, Pawanrat, Prapaporn Jattujan, Saksit Nobsathian, Tanate Poomtong, Prasert Sobhon, and Krai Meemon. "Holothuria scabraextracts exhibit anti-Parkinson potential inC. elegans: A model for anti-Parkinson testing." Nutritional Neuroscience 21, no. 6 (2017): 427–38. http://dx.doi.org/10.1080/1028415x.2017.1299437.

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Ingala, Judith. "An anti-parkinson add-on drug." Geriatric Nursing 6, no. 4 (1985): 193. http://dx.doi.org/10.1016/s0197-4572(85)80081-1.

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Austin, Publishing Group. "Hemodiafiltration for Intoxication with Lithium Unmasking Its Anti-Parkinsonian Effect." Journal of Family Medicine 8, no. 1 (2021): 1237. https://doi.org/10.26420/jfammed.2021.1237.

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From lithium it is known that it exhibits an anti-Parkinson effect [1]. Accordingly, smokers develop less frequently Parkinson&rsquo;s Disease (PD) than the non-smoking population [2]. This is because tobacco contains a significant amount of lithium [3]. The anti-PD effect of lithium is explained by increased autophagy and reduction of intracellular a-synuclein [3]. Lithium inhibits GSK-3<em>&szlig;</em>&nbsp;and consequently increases the&nbsp;<em>&szlig;</em>-catenine activity [4]. Development of a Parkinson crisis due to flushing out of lithium by Hemodiafiltration (HDF), as in the followin
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Kostelnik, Adam, Alexander Cegan, and Miroslav Pohanka. "Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase." BioMed Research International 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/2532764.

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Biperiden is a drug used in Parkinson disease treatment and it serves also as an antiseizures compound in organophosphates poisoning. It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. This enzyme is inhibited by various compounds; however there has not been proposed evidence about interaction with biperiden molecule. We investigated this interaction using standard Ellman’s assay and experimental findings were critically completed with an in silico predicti
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Simon, K., V. Harmat, Z. Török, Z. Böcskei, and I. Hermecz. "Isostructural Metabolites of Two Anti-Parkinson Drugs." Acta Crystallographica Section C Crystal Structure Communications 54, no. 6 (1998): 811–13. http://dx.doi.org/10.1107/s0108270197019896.

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Gerlach, M., and P. Riederer. "Aktuelle präklinische Befunde zu Anti-Parkinson-Mitteln." Der Nervenarzt 74 (March 1, 2003): s2—s6. http://dx.doi.org/10.1007/s00115-003-1481-x.

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Youdim, Moussa BH. "Rasagiline: an anti-Parkinson drug with neuroprotective activity." Expert Review of Neurotherapeutics 3, no. 6 (2003): 737–49. http://dx.doi.org/10.1586/14737175.3.6.737.

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Schiess, Mya. "Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson Neurodegeneration." Archives of Neurology 60, no. 8 (2003): 1043. http://dx.doi.org/10.1001/archneur.60.8.1043.

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RAZZAGHI-ASL, NIMA, SARA SHAHABIPOUR, AHMAD EBADI, and AZAM BAGHERI. "Quantum chemical analysis of potential anti-Parkinson agents." Journal of Chemical Sciences 127, no. 7 (2015): 1211–20. http://dx.doi.org/10.1007/s12039-015-0889-8.

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Kumar, Rajan, Rakesh Kumar, Abhinav Anand, Neha Sharma, and Navneet Khurana. "PREDICTION OF ANTI-PARKINSON POTENTIAL OF PHYTOCONSTITUENTS USING PREDICTION OF ACTIVITY SPECTRA OF SUBSTANCES SOFTWARE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 14 (2018): 48. http://dx.doi.org/10.22159/ajpcr.2018.v11s2.28578.

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Objective: Neurodegenerative disorders are group of diseased conditions in which there is loss of neuron cells occur. The main objective of this study to find/search out the phytochemical with the help of prediction of activity spectra of substances (PASSs), those show maximum activity over the selected targets of the Parkinson’s disease (PD).Methods: PASSs is a valuable software which is used in this study, to predict the anti-Parkinson activity of different compounds. Canonical simplified molecular-input line-entry system is used for the prediction of anti-Parkinson activity which is obtaine
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Dissertations / Theses on the topic "Anti-Parkinson"

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Hussein, Nozad Rashid. "Bioadhesive microparticles and liposomes of anti-Parkinson drugs for nasal delivery." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/9788/.

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The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The limitation of short residence time of the formulations in the nose and poor bioavailability of hydrophilic drugs could be overcome by the inclusion of bioadhesive agents into formulation. The main objective of this study was to develop novel bioadhesive microspheres and liposomes entrapping the anti
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Kanter, Marlene. "Organisationsprinzipien der extrazellulären Matrix in der Substantia nigra des Menschen und ihr Bezug zum Morbus Parkinson." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-62572.

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Der Morbus Parkinson ist durch den selektiven Zelltod der dopaminergen Neurone der Substantia nigra pars compacta gekennzeichnet. Hierbei sind die verschiedenen Populationen pigmentierter Neurone innerhalb der SNc unterschiedlich stark betroffen. Die Ursachen für diese unterschiedliche Schädigung sind noch nicht bekannt. Möglicherweise besteht aber ein Zusammenhang mit der Verteilung der extrazellulären Matrix innerhalb der Substantia nigra. Für die Untersuchung wurden immunhistochemische Methoden an Hirnschnittserien von menschlichen Kontrollgehirnen angewandt. Zur Darstellung von Komponenten
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Nakaoka, Sachiko. "Prescribing pattern of anti-Parkinson drugs in Japan: a trend analysis from 2005 to 2010." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/193574.

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Nakaoka S, Ishizaki T, Urushihara H, Satoh T, Ikeda S, et al. (2014) Prescribing Pattern of Anti-Parkinson Drugs in Japan: A Trend Analysis from 2005 to 2010. PLoS ONE 9(6): e99021. doi:10.1371/journal.pone.0099021<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(社会健康医学)<br>甲第18649号<br>社医博第61号<br>新制||社医||8(附属図書館)<br>31563<br>京都大学大学院医学研究科社会健康医学系専攻<br>(主査)教授 髙橋 良輔, 教授 川上 浩司, 教授 松原 和夫<br>学位規則第4条第1項該当
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Araujo, Dayane Pessoa. "Atividade anti-inflamatória e neuroprotetora da fração de Aspidosperma pyrifolium rica em derivado glicosilado do ácido salicílico." reponame:Repositório Institucional da UFC, 2017. http://www.repositorio.ufc.br/handle/riufc/25372.

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ARAUJO, D. P. Atividade anti-inflamatória e neuroprotetora da fração de Aspidosperma pyrifolium rica em derivado glicosilado do ácido salicílico. 2017. 141 f. Tese (Doutorado em Farmacologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2017.<br>Submitted by Farmacologia Pós-Graduação (posgfarmacologia@gmail.com) on 2017-08-31T14:19:38Z No. of bitstreams: 1 2017_tese_ dparaujo.pdf: 4402876 bytes, checksum: ff7ad728ad291379acc04af1fdd28c20 (MD5)<br>Approved for entry into archive by Erika Fernandes (erikaleitefernandes@gmail.com) on 2017-08-31T16:42:03Z (GMT) No. of bitstr
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Gschmack, Eva Maria Verfasser], Carsten [Gutachter] Scheller, and Thomas [Gutachter] [Dandekar. "Anti-Gehirn-Autoantikörper und deren Bedeutung bei Morbus Parkinson / Eva Maria Gschmack ; Gutachter: Carsten Scheller, Thomas Dandekar." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1147290024/34.

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El, Kodsi Daniel N. "A Redox Chemistry-based Function for Parkinson Disease-linked Parkin Confers Direct, Anti-oxidant Activities in Mammalian Brain." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41129.

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Early-onset Parkinson disease, of which the best studied and most common cause are biallelic mutations in the PRKN gene, is characterized by an age of onset before 40 years. Parkin-deficient patients show slow progression, excellent responsiveness to L-dopa therapy, and are generally spared cognitive decline. At autopsy, PRKN-linked Parkinson disease is further distinguished by relative selectivity in cell loss, namely of dopamine producing neurons in the human brainstem, and the general absence of Lewy body inclusions. Since its discovery two decades ago, the field has focused on the function
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Oliveira, Juciele Valéria Ribeiro de. "Efeito neuroprotetor da formononetina em modelo animal para estudo da doença de Parkinson." Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3267.

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This study aimed to evaluate the antioxidant activity in vitro, as well as and the possible neuroprotective effect in vivo of the isoflavonoid formononetin (FORM) in an experimental model for the study of Parkinson's disease (PD). Among the methods used to determine the antioxidant activity of FORM in vitro, they were elected the DPPH, ABTS and FRAP. In the in vivo assays, FORM was evaluated for its biological activity on experimental PD induced by 6- hydroxydopamine (6-OHDA, 10 μg in 2 μL) injection in the right striatum. Control groups received saline containing 0.02% of ascorbic acid
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Blaudin, de Thé Francois-Xavier. "Engrailed, an anti-ageing homeoprotein." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066204/document.

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Les homéoprotéines sont des facteurs de transcription morphogénétiques qui ont des fonctions cellulaire et non cellulaire-autonomes. Par exemple, En1 et En2 (Engrailed/En) sont importants pour le développement des neurones dopaminergiques du mésencéphale (mDA) et cruciaux pour leur maintien chez l'adulte. Les souris En1+/- présentent une dégénération progressive et spécifique des neurones mDA de la Substantia Nigra pars compacta (SNpc), rappelant la maladie de Parkinson. De plus, l'infusion d'En dans plusieurs modèles de la maladie sauve ces neurones. Dans le modèle MPTP, cela passe par l'augm
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Pinto, Natália Bitú. "Avaliação da atividade neuroprotetora do extrato padronizado de Camellia sinensis e de seus princípios bioativos: envolvimento de ações anti-inflamatórias e antioxidantes." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/13906.

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PINTO, N. B. Avaliação da atividade neuroprotetora do extrato padronizado de Camellia sinensis e de seus princípios bioativos: envolvimento de ações anti-inflamatórias e antioxidantes. 2015. 296 f. Tese (Doutorado em Farmacologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2015.<br>Submitted by Erika Fernandes (erikaleitefernandes@gmail.com) on 2015-11-05T14:03:38Z No. of bitstreams: 1 2015_tese_nbpinto.pdf: 9261753 bytes, checksum: 4bd9df04382dd73463d692c4c5fbd540 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernandes@gmail.com) on 2015-11-05T1
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Zhang, Yan. "Implementation of anti-apoptotic peptide aptamers in cell and "in vivo" models of Parkinson's disease." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0788.

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La maladie de Parkinson (PD) est considérée comme la deuxième maladie neurodégénérative la plus fréquente. L'examen post-mortem de patients parkinsoniens et des modèles physiologiques d’études de la maladie de Parkinson suggèrent la participation de la mort cellulaire programmée, l'inflammation et l'autophagie dues au stress oxydatif, à des mutations ou l’agrégation de protéines au sein des neurones DA. Les aptamères peptidiques sont de petites protéines combinatoires, consistitués d’une plateforme (dans notre cas, la thiorédoxine humaine, hTRX) et une boucle variable insérée dans le domaine a
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Books on the topic "Anti-Parkinson"

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Dan, Luke. Updated Anti Parkinson Diet. Independently Published, 2021.

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PRATT, Gabriella. Complete Guide to Anti-Parkinson Diet for Novices and Experts. Independently Published, 2021.

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New Anti-Parkinson Diet: Using Diet and a High-Energy Food to Protect, Nourish the Brain and Conquer Parkinson Disease. Independently Published, 2020.

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BEVERLEY, Sandra. Anti-Parkinson Diet Cookbook for Beginners: Recipes to Help Prevent and Alleviate Parkinson's Disease. Independently Published, 2022.

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LEMAY, M. I. A. Absolute Guide to Anti-Pakison Diet: A Dietary Guide to Addressing Parkinson Disease with Delectable Meal Plan. Independently Published, 2022.

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Wilson, Lillian. Anti Parkinson Cookbook: The Simple Guide to Manage Your Symptom and Treatment Including Healthy Recipes to Reverse the Disease. Independently Published, 2022.

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COLE, Vivian. Anti-Parkinson Cookbook: A Complete Dietary Guide to Manage, Fight, Reverse and Treat Parkinson's Disease Naturally; with Tons of Healthy Recipes. Independently Published, 2022.

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All about Anti-Parkinson Diet: Expert Guide on Healing and Managing Parkinson's Disease with Diet Includes Delicious Recipes and Getting Started. Independently Published, 2021.

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Einfach Malbuch Für Erwachsene: Nettes Geschenk Für Anti-Stress und Entspannung. Blumen, Mandalas, Tiere, Autos, Vögel, Katzen, Hunde und Mehr. Große Motive Für Patienten Mit Demenz, Sehbehinderung, Alzheimer und Parkinson. Independently Published, 2022.

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Book chapters on the topic "Anti-Parkinson"

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Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, et al. "Anti-Parkinson Drugs." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_34.

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Kallman, Mary Jeanne. "Anti-Parkinson Activity." In Drug Discovery and Evaluation: Pharmacological Assays. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_32.

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Friedman, Joseph H. "Anti-Parkinson Drugs." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_34.

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Kallman, Mary Jeanne. "Anti-Parkinson Activity." In Drug Discovery and Evaluation: Pharmacological Assays. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_32-1.

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Kallman, Mary-Jeanne. "Anti-Parkinson Activity." In Drug Discovery and Evaluation: Pharmacological Assays. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_32-2.

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Friedman, Joseph H. "Anti-Parkinson Drugs." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-27772-6_34-2.

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Gerlach, Manfred, Heinz Reichmann, and Peter Riederer. "Präklinische und klinische Pharmakologie und Wirkungsmechanismen von Anti-Parkinson-Medikamenten." In Die Parkinson-Krankheit. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3746-8_3.

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Dalar, Abdullah, and Muzaffer Mukemre. "Current Medicinal Plants in the Treatment of Parkinson’s Disease." In Brain Health and Medicinal Plants. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359241.8.

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This chapter presents botanical and chemical properties, and therapeutic potential in neurological diseases of medicinal plants currently utilized in Parkinson’s disease. Parkinson’s disease is the second most common neurological brain disease that accompanied by movement disorders. Currently used modern medicines such as levodopa have serious side effects and therefore safe, and effective medicines from natural sources with minimized side effects are necessary for the management and/or treatment of Parkinson’s disease. Natural sources especially plant-based materials are rich in antioxidant c
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Boyina, Hemanth Kumar, Sree Lakshmi Geethakhrishnan, Swetha Panuganti, et al. "In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-32633-3_1.

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Markstein, R., and J. M. Vigouret. "Is D-1 receptor stimulation important for the anti-parkinson activity of dopamine agonists?" In Key Topics in Brain Research. Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-8994-8_31.

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Conference papers on the topic "Anti-Parkinson"

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Schneider, Jakub, Daniel Novak, and Robert Jech. "Optimization of Parkinson Disease treatment combining anti-Parkinson drugs and deep brain stimulation using patient diaries." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319133.

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Marrelli, Maria Fernanda Sanfins, Andréia de Oliveira Pain, Guilherme Cuoghi Bellato, and Marco Antonio Herculano. "LUVAS ANTI-TREMOR: ALTERNATIVA NO TRATAMENTO DO TREMOR DE PARKINSON." In I Fórum de Iniciação em Desenvolvimento Tecnológico e Inovação - PIBITI-FMJ-CNPq. Even3, 2023. http://dx.doi.org/10.29327/1317178.1-5.

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Anil, Prajapati Manisha, Sandesh Kumar Pattanaik, Nainshi, Neha Sharma, and Navneet Kurana. "The revelation of anti - Parkinson, activity of Curcuma albiflora and Curcuma aurantiaca using prediction of activity spectra of substances software." In THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0162977.

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Selman, Selman, Hala Madhi, and Kaiser NeamaMadlum. "Anti-parkinsonian Activity of Borago Officinalis Ethanolic Extract in Rotenone- Induced Rat Model of Parkinson’s Disease." In 5th International Conference on Biomedical and Health Sciences. Cihan University-Erbil, 2024. http://dx.doi.org/10.24086/biohs2024/paper.1288.

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Abstract—Background: Parkinson disease (PD) was one of the most prevalent slow-moving, age-related neurodegenerative diseases, which is characterized by the death of dopaminergic neurons in the substantia nigra (SN). Bradykinesia, stiffness, postural instability, akinesia, and tremor are some clinical motor signs of PD.This study aims to investigate the antioxidant and anti- inflammatory effects of B.Officinalis extract. Materials and Methods:The 70 healthy male Albino rats used in this experiment study,the first group was designated as the healthy control group and other rats were orally admi
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Silva, Jordana Ribeiro da, CARLOS HENRIQUE SANTOS, JULIANA COSTA PARRIÃO DE OLIVEIRA, KAROLINE NUNES RODRIGUES VIANA, and PABLO DIEGO DUARTE DOVERA. "A IMUNOLOGIA E A DOENÇA DE PARKINSON." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6881.

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Introdução: A doença Parkinsoniana (DP) é uma doença neurodegenerativa, que afeta mais de 1% da população, na idade de 60 anos, em indivíduos com mais de 85 anos, essa prevalência chega a 5%. Além do avanço da idade sobre o risco de desenvolver essa patologia, o gênero, principalmente o masculino, aparece como fator de predisposição para a doença. Na sintomatologia observa-se manifestações tanto motoras/não-motoras que incluem desde tremores, rigidez, dificuldade na execução de movimentos voluntários, a lentificação dos movimentos, instabilidade postural e também sintomas neuropsiquiátricos co
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Oliveira, Analice Barbosa Santos De. "O RESVERATROL: UM POLIFENOL NO TRATAMENTO DA DEPRESSÃO." In III Congresso Brasileiro de Ciências Farmacêuticas On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conbracif/65.

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Introdução: O Resveratrol (3,4’, 5-trihidroxiestilbene) é um polifenol abundante na casca e nas sementes da uva e inclusive no vinho, frutas e amendoim e está associado a uma melhora na saúde geral do indivíduo e sabe-se que ele está envolvido na redução de danos neuronais e apoptose e ainda possui uma variedade de bioatividades incluindo propriedades anti doenças cardiovasculares, anticancerígenas, antioxidantes e anti-inflamatórias. É encontrado em uvas vermelhas, vinho tinto, amendoim e outras fontes vegetais. Objetivo: Este trabalho tem por objetivo revisar a literatura existente a respeit
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Silva, Carla Mary Ferreira, Sara Mirian Ferreira Silva, Júlia Cordeiro de Farias, Samuel Cézar Alexandre Silva, and Risonildo Pereira Cordeiro. "USO FITOTERÁPICO DA GRAVIOLA (ANNONA MURICATA LINN) EM TRATAMENTO DE DIVERSAS DOENÇAS." In II Congresso Brasileiro de Ciências Farmacêuticas On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1049.

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Introdução: O uso da A. muricata, na medicina tradicional, muitas vezes está relacionado ao uso de suas folhas, frutos e raízes, sob a forma de chá para tratamento de doenças. Muitos compostos bioativos e fitoquímicos são encontrados na graviola, estudos têm mostrado ação hipotensiva, antiespasmódica, vasodilatadora, relaxante do músculo estomacal e atividade citotóxica contra células cancerígenas a partir dos extratos das folhas e troncos. Objetivo: Explorar o potencial da graviola no tratamento de doenças através de uma revisão de literatura. Material e métodos: Efetuou-se busca em artigos d
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Meyer, Nadine dos Santos, and ALEXANDRE EHRHARDT. "AVALIAÇÃO IN VITRO DA ATIVIDADE ANTIMICROBIANA E ANTIFÚNGICA DE UM ÓLEO A BASE DE CANABIDIOL (CBD) FULL SPECTRUM EM CEPAS DE MICROORGANISMOS DE IMPORTÂNCIA CLÍNICA." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/31.

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Introdução: Cannabis spp. é uma planta conhecida mundialmente pelo seu efeito alucinógeno, considerada uma droga ilícita em vários países, incluindo o Brasil. Ela é usada mundialmente para diversas finalidades, como alimentação, fonte de fibras, cordas, roupas, papel e medicamentos, sendo que na medicina geralmente é utilizada para tratar pacientes com doenças neurodegenerativas. Seus principais compostos são o CBD (canabidiol) e o THC (tetrahidrocanabinol). O único medicamento a base de CBD e THC, liberado pela ANVISA é o Mevatyl® ou Sativex® como é registrado em outros países, é considerado
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Reports on the topic "Anti-Parkinson"

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Zhang, Yu, Chaoliang Sun, Hengxi Xu, et al. Connectivity-Based Subtyping of De Novo Parkinson Disease: Biomarkers, Medication Effects and Longitudinal Progression. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.10.04.

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Abstract:
Parkinson's disease (PD) is characterized by divergent clinical symptoms and prognosis, suggesting the presence of distinct subtypes. Identifying these subtypes is crucial for understanding the underlying pathophysiology, predicting disease progression, and developing personalized treatments. In this study, we propose a connectivity-based subtyping approach, which measures each patient's deviation from the reference structural covariance networks established in healthy controls. Using data from the Parkinson's Progression Markers Initiative, we identified two distinct subtypes of de novo PD pa
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