Relevant bibliographies by topics / Anti-sickling

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Academic literature on the topic 'Anti-sickling'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Anti-sickling"

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Adeniyi, Olayemi, Rafael Baptista, Sumana Bhowmick, et al. "Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia." Journal of Clinical Medicine 11, no. 8 (2022): 2177. http://dx.doi.org/10.3390/jcm11082177.

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Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. Herein, we describe the use of sequential fractionation coupled with in vitro anti-sickling assays to purify the active component. Sickling was induced in HbSS genotype blood samples using sodium metabisulphite (Na2S2O5) or through incubation in 100% N2. Methanol extracts of A. cordifolia leaves and its sub-fractions showed >70% suppression of
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Mohammed, Sara Abdalraheem Mostafa, Elharam Ibrahim Abdalla, Ibrahim Mohammad Eisa, Hiba Yasin Mohamed, Amna Bshier Hassan, and Mohammed Mobarak Elbasheir. "To study the In vitro Anti-Sickling Activity of Adansonia digitata Fruits Extract on Sickle Cells." European Journal of Medicinal Plants 35, no. 6 (2024): 384–92. https://doi.org/10.9734/ejmp/2024/v35i61234.

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Background: Traditional medicine is used along with synthetic pharmaceutical products to enhance health management. There is a high mortality rate of patients with sickle cell disease. Previous studies have indicated that some medicinal plants have shown anti-sickling activity, indicating a new therapeutic approach to manage people affected by this hemoglobinopathy. This study aimed to assess the in vitro anti-sickling activity of Adansonia digitata extract on sickle cells. Materials and Methods: Blood samples used in the evaluation of the anti-sickling activity of Adansonia digitata fruits ex
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&NA;. "Clotrimazole a feasible anti-sickling agent." Inpharma Weekly &NA;, no. 1034 (1996): 19. http://dx.doi.org/10.2165/00128413-199610340-00039.

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KOÇAK, RIKKAT, FIKRI BAŞLAMIŞLI, BIROL GÜVENÇ, LÜLÜFER TAMER, KAIRGUELDY S. AIKIMBAEV, and TURGAY ISBIR. "Bencyclane as an anti‐sickling agent." British Journal of Haematology 92, no. 2 (1996): 329–31. http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1466.x.

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Ejele, Agunna Everest, and Pascal Chukwuemeka Njoku. "Anti-sickling potential ofAloe vera extract." Journal of the Science of Food and Agriculture 88, no. 8 (2008): 1482–85. http://dx.doi.org/10.1002/jsfa.3036.

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Eman Ali Abuagla Dafaalla and Amira Ahmed Khalid Humeida. "The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan." World Journal of Advanced Research and Reviews 10, no. 3 (2021): 317–21. http://dx.doi.org/10.30574/wjarr.2021.10.3.0280.

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In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders of hemoglobin that has complications and becomes world problem. Nigella sativa NS (black seed) has been reported to have calcium antagonist and antioxidant activities, both of which play a role in the management of sickle cell anemia. The aim of the current study was to evaluate of the anti-sickling activity of the NS extracts, forty patients with sickle cell anemia were recruited for the study. A total of 3ml of venous blood was collected from each patient after obtaining the consent and the ethical approval, the
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Lu, Lu, Zhen Li, He Li, Xuejin Li, Peter G. Vekilov, and George Em Karniadakis. "Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies." Science Advances 5, no. 8 (2019): eaax3905. http://dx.doi.org/10.1126/sciadv.aax3905.

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Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we developed a kinetic model based on the classical nucleation theory to examine the effectiveness of potential anti-sickling drug candidates. We validated this model by comparing its predictabi
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Eman, Ali Abuagla Dafaalla, and Ahmed Khalid Humeida Amira. "The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan." World Journal of Advanced Research and Reviews 10, no. 3 (2021): 317–21. https://doi.org/10.5281/zenodo.5067675.

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In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders of hemoglobin that has complications and becomes world problem.&nbsp;<em>Nigella sativa</em>&nbsp;NS (black seed) has been reported to have calcium antagonist and antioxidant activities, both of which play a role in the management of sickle cell anemia. The aim of the current study was to evaluate of the anti-sickling activity of the NS extracts, forty patients with sickle cell anemia were recruited for the study. A total of 3ml of venous blood was collected from each patient after obtaining the consent and the et
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Moji, C. Adeyeye, A. Gbadero Daniel, O. Farayola Lawrence, et al. "Evaluation of an Undocumented Polyherbal (Faradin®) Used for the Treatment of Sickle Cell Disease in West Africa. Part I: Phytochemistry and Ex-vivo Anti-sickling Study." British Journal of Pharmaceutical Research 17, no. 1 (2017): 1–14. https://doi.org/10.9734/BJPR/2017/33605.

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<strong>Background: </strong>An undocumented complementary and alternative medicine (CAM)- Faradin® - was screened for its phytochemicals, anti-sickling effect using a clinical protocol, and toxicity. Faradin is a polyherbal made up of <em>Zanthoxylum zanthoxyloides</em>, <em>Alnus glutinosa</em> and <em>Alchornea cordofolia</em>. <strong>Methods: </strong>The polyherbal and the individual components (coded V, M, and F) were separately screened for phytochemicals such as alkaloids, phenols, flavonoids, sterols and coumarins, using standard tests. Institutional Review Board approved clinicalpro
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Darwish, Noureldien, Osheiza Abdulmalik, and Shaker A. Mousa. "Anti-Inflammatory Activities of Sulfated Non-Anticoagulant Heparin Derivative Beyond Its Anti-Sickling and Anti-Selectin for the Effective Management of Sickle Cell Disease." Blood 136, Supplement 1 (2020): 27. http://dx.doi.org/10.1182/blood-2020-141632.

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Sickle cell disease (SCD) is an autosomal recessive genetic disease caused by the inheritance of a single point mutation, resulting in abnormal sickle hemoglobin (HbS). During hypoxia or dehydration, HbS polymerizes to form insoluble aggregates and induces sickling of red blood cells (RBCs). RBC sickling increases the adhesiveness of RBCs to alter the rheological properties of the blood and trigger inflammatory responses, leading to hemolysis, vasoocclusive crisis, pulmonary complications, plethora, and other pathological sequelae. Glycosaminoglycans, such as low molecular weight heparin (LMWH
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Dissertations / Theses on the topic "Anti-sickling"

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Parikh, Apurvasena. "IN-VITRO PK/PD PROFILING AND MODELING OF THE ANTI-SICKLING AGENTS, 5-HYDROXYMETHYL FURFURAL (5-HMF) AND NOVEL SYNTHETIC ALLOSTERIC EFFECTORS OF HEMOGLOBIN (AEH) IN HUMAN WHOLE BLOOD." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/542.

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Introduction. 5-HMF and novel INN-compounds are left-shifting AEH, shown to have anti-sickling action by forming transiently covalent Schiff-base adducts with hemoglobin (Hb), thereby increasing the Hb O2-affinity. They are hypothesized to be substrates for aldehyde dehydrogenase (ALDH) in the liver and red blood cells (RBC). Methods. Biopharmaceutical assessments were made for AEH, using calculated physicochemical properties. Their in-vitro hepatic metabolism (mediated by ALDH) was characterized using hepatic cytosol, and in-vitro-in-vivo extrapolations (IVIVE) were made. Inter-species differ
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Paz, Odailson Santos. "Triagem in silico e avalia??o in vitro de compostos antifalcizantes." Universidade Estadual de Feira de Santana, 2017. http://localhost:8080/tede/handle/tede/496.

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Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2017-08-08T21:31:24Z No. of bitstreams: 1 TESE_Odailson Paz - com ficha.pdf: 4071411 bytes, checksum: 033f0c18eb721e7010e1ddd7ec27e10c (MD5)<br>Made available in DSpace on 2017-08-08T21:31:24Z (GMT). No. of bitstreams: 1 TESE_Odailson Paz - com ficha.pdf: 4071411 bytes, checksum: 033f0c18eb721e7010e1ddd7ec27e10c (MD5) Previous issue date: 2017-05-25<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Adenosine receptors are considered as potential targets for the development of drugs against dif
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Book chapters on the topic "Anti-sickling"

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Jain, Shweta, Ankur Vaidya, Kamal Shah, Durgesh Nandini Chauhan, and Nagendra Singh Chauhan. "Anti-sickling Herbs." In Plant and Human Health, Volume 3. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-04408-4_12.

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Oniyangi, Oluseyi, and Ugochi O. Ogu. "Niprisan and Other Homegrown Anti-Sickling Medications." In Sickle Cell Disease in Sub-Saharan Africa. Routledge, 2024. http://dx.doi.org/10.4324/9781003463931-16.

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Saxena, Shweta, Sweta Prakash, and Sadhna Panday. "Crop Improvement Technology With Lawsonia inermis." In Green Chemistry for the Development of Eco-Friendly Products. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9851-1.ch010.

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Lawsonia inermis L. (family Lythraceae), often known as henna, is a dye-producing plant cultivated in various parts of the world for cosmetic purposes. Since time immemorial, leaf powder made from this little tree has been used to beautify skin, hair, fingernails, leather, silk, and wool. The plant's leaf, which contains an active dye (red orange pigment), lawsone, is widely employed in cosmetic and pharmaceutical industries (2-hydroxy-1,4 naphthoquinone). Lawsone, an essential secondary metabolite, accumulates in the plant's aerial parts, with the highest concentration of 1.0–1.4% in the youn
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Mishra, Meenakshi, Vijaylakshmi Jain, and Pankaj Kishor Mishra. "ANTISICKLING EFFECT OF ALLIUM SATIVUM AND CARICA PAPAYA." In Futuristic Trends in Medical Sciences Volume 3 Book 17. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bgms17ch1.

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Present study deals with those antioxidant molecules might effectively block the polymerization of sickle cell haemoglobin while also enhancing the oxidant status of sickle erythrocytes. The differing concentrations of antioxidant molecules, such as polyphenol and flavonoids, found in the sections of Carica papaya and Allium sativum, could be the cause of the disparity between the antisickling properties. Additionally, the degree of the active antisickling drugs would be determined by the molecules' affinity with the haemoglobin binding site. The heme pocket and the erythrocyte membrane are th
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