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Journal articles on the topic 'Anti-sickling'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Adeniyi, Olayemi, Rafael Baptista, Sumana Bhowmick, et al. "Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia." Journal of Clinical Medicine 11, no. 8 (2022): 2177. http://dx.doi.org/10.3390/jcm11082177.

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Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. Herein, we describe the use of sequential fractionation coupled with in vitro anti-sickling assays to purify the active component. Sickling was induced in HbSS genotype blood samples using sodium metabisulphite (Na2S2O5) or through incubation in 100% N2. Methanol extracts of A. cordifolia leaves and its sub-fractions showed >70% suppression of

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2

Mohammed, Sara Abdalraheem Mostafa, Elharam Ibrahim Abdalla, Ibrahim Mohammad Eisa, Hiba Yasin Mohamed, Amna Bshier Hassan, and Mohammed Mobarak Elbasheir. "To study the In vitro Anti-Sickling Activity of Adansonia digitata Fruits Extract on Sickle Cells." European Journal of Medicinal Plants 35, no. 6 (2024): 384–92. https://doi.org/10.9734/ejmp/2024/v35i61234.

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Background: Traditional medicine is used along with synthetic pharmaceutical products to enhance health management. There is a high mortality rate of patients with sickle cell disease. Previous studies have indicated that some medicinal plants have shown anti-sickling activity, indicating a new therapeutic approach to manage people affected by this hemoglobinopathy. This study aimed to assess the in vitro anti-sickling activity of Adansonia digitata extract on sickle cells. Materials and Methods: Blood samples used in the evaluation of the anti-sickling activity of Adansonia digitata fruits ex

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3

&NA;. "Clotrimazole a feasible anti-sickling agent." Inpharma Weekly &NA;, no. 1034 (1996): 19. http://dx.doi.org/10.2165/00128413-199610340-00039.

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4

KOÇAK, RIKKAT, FIKRI BAŞLAMIŞLI, BIROL GÜVENÇ, LÜLÜFER TAMER, KAIRGUELDY S. AIKIMBAEV, and TURGAY ISBIR. "Bencyclane as an anti‐sickling agent." British Journal of Haematology 92, no. 2 (1996): 329–31. http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1466.x.

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5

Ejele, Agunna Everest, and Pascal Chukwuemeka Njoku. "Anti-sickling potential ofAloe vera extract." Journal of the Science of Food and Agriculture 88, no. 8 (2008): 1482–85. http://dx.doi.org/10.1002/jsfa.3036.

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6

Eman Ali Abuagla Dafaalla and Amira Ahmed Khalid Humeida. "The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan." World Journal of Advanced Research and Reviews 10, no. 3 (2021): 317–21. http://dx.doi.org/10.30574/wjarr.2021.10.3.0280.

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In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders of hemoglobin that has complications and becomes world problem. Nigella sativa NS (black seed) has been reported to have calcium antagonist and antioxidant activities, both of which play a role in the management of sickle cell anemia. The aim of the current study was to evaluate of the anti-sickling activity of the NS extracts, forty patients with sickle cell anemia were recruited for the study. A total of 3ml of venous blood was collected from each patient after obtaining the consent and the ethical approval, the

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7

Lu, Lu, Zhen Li, He Li, Xuejin Li, Peter G. Vekilov, and George Em Karniadakis. "Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies." Science Advances 5, no. 8 (2019): eaax3905. http://dx.doi.org/10.1126/sciadv.aax3905.

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Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we developed a kinetic model based on the classical nucleation theory to examine the effectiveness of potential anti-sickling drug candidates. We validated this model by comparing its predictabi

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8

Eman, Ali Abuagla Dafaalla, and Ahmed Khalid Humeida Amira. "The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan." World Journal of Advanced Research and Reviews 10, no. 3 (2021): 317–21. https://doi.org/10.5281/zenodo.5067675.

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In Sudan, sickle cell anemia (SCA) is one of the most common inherited disorders of hemoglobin that has complications and becomes world problem. <em>Nigella sativa</em> NS (black seed) has been reported to have calcium antagonist and antioxidant activities, both of which play a role in the management of sickle cell anemia. The aim of the current study was to evaluate of the anti-sickling activity of the NS extracts, forty patients with sickle cell anemia were recruited for the study. A total of 3ml of venous blood was collected from each patient after obtaining the consent and the et

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9

Moji, C. Adeyeye, A. Gbadero Daniel, O. Farayola Lawrence, et al. "Evaluation of an Undocumented Polyherbal (Faradin®) Used for the Treatment of Sickle Cell Disease in West Africa. Part I: Phytochemistry and Ex-vivo Anti-sickling Study." British Journal of Pharmaceutical Research 17, no. 1 (2017): 1–14. https://doi.org/10.9734/BJPR/2017/33605.

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<strong>Background: </strong>An undocumented complementary and alternative medicine (CAM)- Faradin® - was screened for its phytochemicals, anti-sickling effect using a clinical protocol, and toxicity. Faradin is a polyherbal made up of <em>Zanthoxylum zanthoxyloides</em>, <em>Alnus glutinosa</em> and <em>Alchornea cordofolia</em>. <strong>Methods: </strong>The polyherbal and the individual components (coded V, M, and F) were separately screened for phytochemicals such as alkaloids, phenols, flavonoids, sterols and coumarins, using standard tests. Institutional Review Board approved clinicalpro

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10

Darwish, Noureldien, Osheiza Abdulmalik, and Shaker A. Mousa. "Anti-Inflammatory Activities of Sulfated Non-Anticoagulant Heparin Derivative Beyond Its Anti-Sickling and Anti-Selectin for the Effective Management of Sickle Cell Disease." Blood 136, Supplement 1 (2020): 27. http://dx.doi.org/10.1182/blood-2020-141632.

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Sickle cell disease (SCD) is an autosomal recessive genetic disease caused by the inheritance of a single point mutation, resulting in abnormal sickle hemoglobin (HbS). During hypoxia or dehydration, HbS polymerizes to form insoluble aggregates and induces sickling of red blood cells (RBCs). RBC sickling increases the adhesiveness of RBCs to alter the rheological properties of the blood and trigger inflammatory responses, leading to hemolysis, vasoocclusive crisis, pulmonary complications, plethora, and other pathological sequelae. Glycosaminoglycans, such as low molecular weight heparin (LMWH

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11

Kumar Kurre, Mukesh, Suneeta Patra, and P. K. Patra. "IN VITRO ANTI-SICKLING ACTIVITIES OF SORGHUM BICOLOR (L.) MOENCH." International Journal of Advanced Research 13, no. 03 (2025): 326–32. https://doi.org/10.21474/ijar01/20570.

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The use of medicinal plants to cure and prevent human ailments, including Sickle Cell Disease (SCD), is an old traditional method. Sorghum bicolor has been used traditionally in the management of SCD. The objective of the current study was phytochemical evaluation and screening of anti-sickling activity of various fractions on sodium metabisulphite induced sickling of HbSS erythrocytes. Chemical screening of extract of Sorghum bicolor seeds revealed the presence of flavonoids, alkaloids, saponins, phenol, and tannin. The sickle reversal test results showed that ethyl acetate soluble fraction h

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12

Du, E., Laurel Mendelsohn, James S. Nichols, Ming Dao, and Gregory J. Kato. "Quantification of Anti-Sickling Effect of Aes-103 in Sickle Cell Disease Using an in Vitro Microfluidic Assay." Blood 124, no. 21 (2014): 2699. http://dx.doi.org/10.1182/blood.v124.21.2699.2699.

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Abstract Background: Under hypoxic conditions, sickle hemoglobin (HbS) polymerizes, causing morphologic distortion (sickling) of red blood cells (RBCs) in sickle cell disease (SCD). Aes-103 (5-hydroxymethylfurfural, 5-HMF) can stabilize the R-state and increase the oxygen affinity of hemoglobin, inhibiting the intracellular polymerization of HbS. Using a microfluidics-based hypoxia assay, we were able to track sickling of individual cells and quantify the anti-sickling effect of Aes-103 at millimolar (mM) levels in blood from SCD patients on hydroxyurea treatment (on-HU) and not on hydroxyurea

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13

Yunus, Mohammed, Rawda Aljadar, and Amr Zaher. "Turmeric and Fenugreek - Herbal Agents to Alleviate Sickle Cell Disease." Clinical Medical Reviews and Reports 3, no. 7 (2021): 01–06. http://dx.doi.org/10.31579/2690-8794/082.

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Introduction: Sickle cell disease (SCD) is a genetic disorder with autosomal recessive inheritance causing abnormal hemoglobin. It is an important medical problem globally as well as in our community at Eastern province of Saudi Arabia. It accounts for large numbers of morbidity and to a lesser extent mortality. Several natural plant products over the world, which were known in some communities and their traditional healers, were studied and found to have properties in improving SCD manifestation. This research was planned to explore if any plant product under our study could prove being an ef

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14

Chang, Alicia, So Hyun Park, Ciaran M. Lee, Alireza Paikari, Gang Bao, and Vivien A. Sheehan. "Sickle Human Umbilical Cord Derived Erythroid Progenitor Cells (S-HUDEP2): An Ideal in-Vitro System for Screening Anti-Sickling Compounds for Sickle Cell Disease." Blood 132, Supplement 1 (2018): 3675. http://dx.doi.org/10.1182/blood-2018-99-117158.

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Abstract Background: Sickle Cell Disease (SCD) is a devastating inherited disease, characterized by polymerization of sickle hemoglobin under deoxygenated conditions that can lead to acute pain crises, ischemia, and chronic organ damage. Pharmacologic anti-sickling agents that decrease polymerization are currently under investigation, however there is no consistent in vitro system to study these compounds; whole patient blood, subject to clinical variability and limited supply, is most often used. Human Umbilical Cord Derived Erythroid Progenitor 2 cells (HUDEP2) are an immortalized CD34+ hema

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15

Gbolo, Benjamin Z., K. N. Ngbolua, Bobette N. Ciala, et al. "LC-MS/MS Analysis of crude Flavonoid Compounds from <i>Justicia secunda</i> from Democratic Republic of the Congo and evaluation of their antisickling Activity." Natural Resources for Human Health 4, no. 4 (2024): 387–97. http://dx.doi.org/10.53365/nrfhh/192594.

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<i>Justicia secunda</i> Vahl (Acanthaceae) is a tropical herbaceous plant traditionally used by indigenous peoples of the Democratic Republic of the Congo (DRC) to treat symptoms associated with sickle cell disease (SCD), a genetic condition with life-threatening complications. Given the lack of side-effect-free drugs, alternative herbal therapies that can reduce or reverse red blood cell sickling may serve as safe and effective treatments. The primary objective of this study is to conduct a phytochemical screening of crude flavonoids extracted from <i>J. secunda</i> us

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16

Ekeke, G. I., and G. O. Ibeh. "Sialic acid in sickle cell disease." Clinical Chemistry 34, no. 7 (1988): 1443–46. http://dx.doi.org/10.1093/clinchem/34.7.1443.

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Abstract Neuraminic (sialic) acid concentrations in serum from normal and sickle cell (HbSS) subjects were determined for discrete age groups from childhood through adolescence. Values in sickle cell disease were consistently lower over the entire age range. We further investigated the effect of exogenous sialic acid on the rate of sickling reversion of HbSS erythrocytes and demonstrated that this compound in millimole per liter concentrations could revert pre-sickled erythrocytes to their normal morphology in a concentration-dependent manner. When subjected to partial de-sialation with sialid

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17

Mgbemene, C. N., and F. C. Ohiri. "Anti-sickling Potential of Terminalia catappa Leaf Extract." Pharmaceutical Biology 37, no. 2 (1999): 152–54. http://dx.doi.org/10.1076/phbi.37.2.152.6090.

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18

Stuart, J., F. B. O. Mojiminiyi, P. C. W. Stone, S. J. Culliford, and J. C. Ellory. "Additive in vitro effects of anti-sickling drugs." British Journal of Haematology 86, no. 4 (1994): 820–23. http://dx.doi.org/10.1111/j.1365-2141.1994.tb04836.x.

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19

Zhang, Yujin, Vladimir Berka, Anren Song, Rodney E. Kellems, and Yang Xia. "Sphingosine 1-Phosphate Induces Erythrocytes Sickling in Sickle Cell Disease By Promoting Hemoglobin S Aggregation." Blood 124, no. 21 (2014): 2673. http://dx.doi.org/10.1182/blood.v124.21.2673.2673.

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Abstract Sickle cell disease (SCD) is a genetic hemolytic disease with high morbidity and mortality affecting millions of individuals worldwide. Although SCD was identified a century ago, we still lack effective mechanism-based therapies to treat this disease. Our recent study showed inhibition of sphingosine kinase 1 (Sphk1, the enzyme that produces S1P) significantly decreased S1P level in sickle erythrocytes, attenuated sickling cells. We also found sickling was induced by high concentration (10µM) but not low concentration (0.5 µM) of S1P, which indicates S1P induced sickling is independen

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20

Phanus-umporn, Chuleeporn, Watshara Shoombuatong, Veda Prachayasittikul, Nuttapat Anuwongcharoen, and Chanin Nantasenamat. "Privileged substructures for anti-sickling activity via cheminformatic analysis." RSC Advances 8, no. 11 (2018): 5920–35. http://dx.doi.org/10.1039/c7ra12079f.

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Cheminformatic approaches (classification structure–activity relationship models based on 12 fingerprint classes) were employed for deducing privileged substructures giving rise to the anti-sickling activity of an investigated set of 115 compounds.

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21

Phanus-umporn, Chuleeporn, Watshara Shoombuatong, Veda Prachayasittikul, Nuttapat Anuwongcharoen, and Chanin Nantasenamat. "Correction: Privileged substructures for anti-sickling activity via cheminformatic analysis." RSC Advances 8, no. 15 (2018): 8233. http://dx.doi.org/10.1039/c8ra90013b.

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22

Mendelsohn, Laurel G., Leah Pedoeim, Yekai Kevin Wang, et al. "The Anti-Sickling Agent Aes-103 Decreases Sickle Erythrocyte Fragility, Hypoxia-Induced Sickling and Hemolysis In Vitro." Blood 122, no. 21 (2013): 940. http://dx.doi.org/10.1182/blood.v122.21.940.940.

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Abstract Background The polymerization of hemoglobin S results in red cell morphological changes and fragility, which promotes hemolysis. Aes-103 (5-hydroxymethylfurfural, 5-HMF) is a clinical-stage candidate anti-sickling agent that binds to alpha subunits of hemoglobin, increases its oxygen affinity and stabilizes the R-state. In vitro at, millimolar levels, it inhibits hypoxia-induced sickling and in vivo protects sickle cell mice against hypoxia-induced death. We have found in vitro that Aes-103 increases oxygen affinity of red cells from healthy control subjects and from patients with sic

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23

Dr., Muhammad Umer Hafiz Muhammad Bilal Basit Dr. Yamina Nasir. "A COMPARATIVE RESERARCH ON THE IN VITRO ANTI SICKLING POTENTIAL IN VARIOUS ANTISICKLING DRUGS." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5739–43. https://doi.org/10.5281/zenodo.1298691.

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<strong><em>Objective: </em></strong><em>Tellurite, thiocyanate and hydroxyurea are those chemical agents renowned to be used as antisickling drugs. Antisickling characteristics of these agents were comparatively investigated and studied in this research.<strong>Methodology: </strong></em><em>Collection of sickle blood was carried out from the patients attending Allied Hospital, Faisalabad (Haematology Department) in the time period of September, 2016 to October, 2017. </em><em>Incubation of human sickle blood with drugs concentrations of both in vitro and in vivo was carried out. By employing

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24

Onuoha, Chinyere Henrietta, Charity Chinenye Nwachukwu, Ruth Tochukwu Nwachukwu, Chinwe Glory Nwogu Nwogu, Chieme Sunday Chukwudoruo, and Favour Ntite Ujowundu. "Comparative evaluation of proximate composition and anti-sickling potential of Annona muricata Linn seeds and leaves." AROC in Natural Products Research 01, no. 02 (2021): 29–35. http://dx.doi.org/10.53858/arocnpr01022935.

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Background: Annona muricata Linn is a notable, well-studied plant of therapeutic value. Based on the abundant pharmacological constituents contained in the understudied plant, it is imperative that the plant parts are investigated for nutritional value and anti-sickling potentials. Sickle cell anaemia (SCA) is an inheritable haematological disorder, caused by an amino acid substitution on the haem protein. The outcomes for SCA are poor health indices and high mortality. Therefore, the use of natural products is necessary and widely promoted in countries with poor health infrastructure. Methods

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25

Currie, Bruce L., and Michael E. Johnson. "Amino Acid and Peptide Approaches to Anti-sickling Agents." Current Medicinal Chemistry 1, no. 5 (1995): 418–22. http://dx.doi.org/10.2174/092986730105220216104353.

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Sickle cell anemia is a genetic disease that affects a large number of people throughout the world. This disease is very well understood at the molecular level, but for which there is still no effective treatment or cure. Phenylalanine, a natural amino acid, has long been known to inhibit the aggregation of sickle hemoglobin (HbS) that leads to the symptoms of sickle cell anemia. However, phenylalanine is weakly potent and thus limited as a potential treatment. Various investigators have developed approaches that seek to improve the effectiveness of amino acid and peptide analogues as anti-sic

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26

Mousa, Shaker A., Noureldien Hassan Elsayed Darwish, Vandhana Muralidharan-Chari, et al. "Multi-Modal Mechanisms and Anti-Sickling of Novel Sulfated Non-Anticoagulant Low Molecular Weight Heparin in Sickle Cell Disease." Blood 132, Supplement 1 (2018): 265. http://dx.doi.org/10.1182/blood-2018-99-115121.

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Abstract The pathogenesis of Sickle Cell Disease (SCD) comprises a complex interplay of factors associated with vascular endothelial activation, intense inflammation, and increased sickle cell adhesion. Microvascular occlusion in SCD is initiated by adhesion of sickle red blood cells (RBCs) to the endothelium, leading to acute painful vasoocclusive crisis (VOC) and clinical morbidity. Current treatment strategies remain sub-optimal and are limited by significant side effects. The inherent complexity of SCD makes it unlikely that a single therapeutic strategy will be universally beneficial. We

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27

Fatokun, OT, JM Agbedahunsi, and AA Elujoba. "Antisickling Activities of Some Nigerian Medicinal Plants." Nigerian Journal of Natural Products and Medicine 19 (August 31, 2015): 92–100. http://dx.doi.org/10.4314/njnpm.v19i0.10.

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Sickle cell anaemia (SCA) is a genetic condition caused by defective haemoglobin molecules. Symptoms are often associated with painful crisis often accompanied with vaso-occlusion, severe anaemia, acute chest syndrome, stroke, multiple organ failure, etc. In the pursuit of searching for suitable and affordable anti-sickling herbal remedies, aqueous and ethanolic extracts of ten medicinal plants from relevant previous ethnomedical records, were screened using standard methods involving whole HbSS blood and found to possess varying degrees of anti-sickling activities. For example, Anthocleista v

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28

Yousef, Zahraa M. Al, Elaf A. Alaswad, M‑Zaki M. ElAssouli, et al. "Anti sickling effect of Senna alexandrina, Aerva javanica , and Ficus palmata extracts on sickle cell disorder." Tropical Journal of Pharmaceutical Research 22, no. 3 (2023): 571–77. http://dx.doi.org/10.4314/tjpr.v22i3.14.

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Purpose: To investigate the anti-sickling activity of Senna alexandrina, Aerva javanica, and Ficus palmate extracts. Methods: The leaves were extracted with water and methanol. The anti-sickling effect of extracts was determined using blood from 20 sickle cell disease (SCD) patients by mixing it with 500 and 1000 μg/mL of extract. The treated blood samples were then examined under a light microscope. The osmotic fragility of erythrocytes was determined using 4 mL (0 – 0.9 %) buffered saline mixed with 1 mL extract (500 μg/mL) and 0.05 mL sickled red blood cells (RBCs). Results: Aerva javanica

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29

Kumar Pandey, Abhishek, Ajay Harit, and Kamlesh Sonekar. "Quantitative estimation of secondary metabolites, in-vitro antioxidant, anti-inflammatory and anti-sickling activity of leaf of Ficus virens Aiton." International Journal of Ayurvedic Medicine 16, no. 1 (2025): 52–63. https://doi.org/10.47552/ijam.v16i1.5317.

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Sickle cell anaemia is a severe global disease marked by oxidative stress and painful episodes. This study evaluates the antioxidant, anti-inflammatory, and anti-sickling properties of the ethanolic extract of Ficus virens Aiton leaves. Total phenolic (TPC), tannin (TTC), and flavonoid (TFC) contents were assessed spectrophotometrically, while antioxidant activity was measured using DPPH, anti-inflammatory activity via the HRBC method, and anti-sickling effects through Emmel and reversibility tests. The extract showed high TPC (79.84±2.77 µg/mg GAE), TTC (10.51±0.62 µg/mg GAE), and TFC (132.62

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30

Dasgupta, Trisha, Mary E. Fabry, and Dhananjay K. Kaul. "Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298, no. 2 (2010): R394—R402. http://dx.doi.org/10.1152/ajpregu.00611.2009.

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In sickle cell disease (SCD), the events originating from hemoglobin S polymerization and intravascular sickling lead to reperfusion injury, hemolysis, decreased nitric oxide (NO) bioavailability, and oxidative stress. Oxidative stress is implicated as a contributing factor to multiple organ damage in SCD. We hypothesize that inhibition of sickling by genetic manipulation to enhance antisickling fetal hemoglobin (HbF) expression will have an ameliorating effect on oxidative stress by decreasing intravascular sickling and hemolysis and enhancing NO bioavailability. We tested this hypothesis in

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O. A., Oyedapo,, Cyril-Olutayo C.M., Agbedahunsi, J.M., Adenegan-Alakinde, T.A., and Baderinwa-Adejumo, A.O. "A Comparative Evaluation of the Antisickling, Elemental and Proximate Analysis of the Leaves of Three Khaya species Found in Nigeria." European Journal of Medicinal Plants 35, no. 6 (2024): 139–49. http://dx.doi.org/10.9734/ejmp/2024/v35i61214.

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Sickle cell disease (SCD) is traditionally treated in Nigeria by the Traditional Medical Practitioners (TMPs) with medicinal plants and other plant products. One of the herbs commonly used singly or in combination with other plant materials is Khaya, which is widely distributed in Africa, with three species existing in Nigeria. These are Khaya senegalensis A. Juss (KS), Khaya grandifoliola (WELW) CDC (KG) and Khaya ivorensis A. Chev. (KI). In this study we evaluated the anti-sickling activities of the leaf extracts of the three Khaya species leaves with a view to authenticating the ethnomedici

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32

Rogers, Stephen C., Parikshit Moitra, Mary Brummet, et al. "Compound Nanoparticle 5HMF-Prodrug Formulations for Optimized Anti-Sickling Therapy." Blood 140, Supplement 1 (2022): 5380–81. http://dx.doi.org/10.1182/blood-2022-168781.

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33

Paz, Odailson Santos, Milena de Jesus Pinheiro, Renan Fernandes do Espirito Santo, Cristiane Flora Villarreal, and Marcelo Santos Castilho. "Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach." European Journal of Medicinal Chemistry 136 (August 2017): 487–96. http://dx.doi.org/10.1016/j.ejmech.2017.05.035.

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34

Gupta, Dipti, Sarah Sturtevant, Benjamin Vieira, Yukio Nakamura, Sriram Krishnamoorthy, and Melanie Demers. "Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery." Blood 134, Supplement_1 (2019): 3559. http://dx.doi.org/10.1182/blood-2019-127330.

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Sickle cell disease (SCD) is a genetic disorder caused by a missense mutation in the beta-globin gene [Glu6Val] resulting in the formation of HbS (sickle hemoglobin). HbS polymerizes under low oxygen tension causing an array of severe pathophysiological complications, including vaso-occlusion, pain and hemolytic anemia. Traditionally, research efforts toward studying anti-sickling effects of various pathways and compounds in vitro have been made using sickle cell patient derived samples. However, such studies are limited based on sample availability and a large degree of phenotypic variability

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35

Bourgeaux, Vanessa, Olivier Hecquet, Dominique Rigal, Alain Francina, and Yann Godfrin. "Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling." Blood 112, no. 11 (2008): 1418. http://dx.doi.org/10.1182/blood.v112.11.1418.1418.

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Abstract Sickle cell disease (SCD) is characterised by abnormal haemoglobin S (HbS). Under hypoxic conditions, HbS crystallizes, inducing sickling of red blood cells. Consequently, patients have a high risk of vaso-occlusive painful crisis. Red cell exchange transfusions remain an effective therapy in the acute and chronic treatment of SCD: the patient’s red blood cells (RBC) are removed and replaced by homologous normal red cells. Red cell exchange can provide needed oxygen carrying capacity while reducing the overall viscosity of blood (P.S. Swerdlow, 2006). We propose a novel preventive and

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36

Sontakke, Sonam Santosh, Shubhangi K. Pingle, Vinod Manikrao Ramteke, et al. "An in vitro evaluation of Kiratadi Mandura Vati for the management of sickle cell anemia." AYU (An International Quarterly Journal of Research in Ayurveda) 45, no. 3 (2024): 168–75. https://doi.org/10.4103/ayu.ayu_172_23.

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Abstract Background: Sickle cell anemia (SCA) is a hemoglobinopathy caused by a point mutation on the 11th chromosome. SCA does not have a clear Ayurveda reference, yet it could be considered as Panduroga (anemia) due to its signs and symptoms. Aim: This investigation aimed to determine the anti-sickling activity of herbo-mineral formulation Kiratadi Mandura (KTM) Vati in an in vitro model. Materials and methods: KTM was prepared and analytical testing of KTM was performed according to the method described in Ayurvedic Pharmacopoeia of India. Blood samples from SCA, normal, and carrier patient

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Keidan, A. J., M. C. Sowter, C. S. Johnson, S. S. Marwah, and J. Stuart. "Pharmacological modification of oxygen affinity improves deformability of deoxygenated sickle erythrocytes: a possible therapeutic approach to sickle cell disease." Clinical Science 76, no. 4 (1989): 357–62. http://dx.doi.org/10.1042/cs0760357.

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1. The formation of polymerized haemoglobin S in sickle cells is critically dependent on the concentration of deoxygenated haemoglobin so that compounds which increase the oxygen affinity of haemoglobin S are potential anti-sickling agents. 2. BW12C [5-(2-formyl-3-hydroxyphenoxy)pentanoic acid] and BWA589C [4-(2-formyl-3-hydroxyphenoxymethyl)benzoic acid] are aromatic benzaldehydes that cause a dose-dependent left-shift of the oxygen saturation curve of haemoglobin S by stabilization of its oxy-(R)-conformation. 3. A 5 μm pore filtration method, which is highly sensitive to polymerization of h

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Krasias, Ioannis. "The Anti-Sickling Properties of Medicinal Plants, Insights in Botanical Medicine*." American Journal of Molecular Biology 11, no. 04 (2021): 165–89. http://dx.doi.org/10.4236/ajmb.2021.114013.

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Naiho, A., B. Okonkwor, and C. Okoukwu. "Anti-Sickling and Membrane Stabilizing Effects of Carica papaya Leaf Extract." British Journal of Medicine and Medical Research 6, no. 5 (2015): 484–92. http://dx.doi.org/10.9734/bjmmr/2015/14608.

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CHAMBHARE, Mahadev R., Nitin S. KADAM, Pooja DOSHI, Sudam L. KATE, Harichandra A. NIKULE, and Tukaram D. NIKAM. "Anti-sickling potential and bioactive metabolites from edible oil-yielding crop Guizotia abyssinica (L.f.) Cass." Notulae Scientia Biologicae 17, no. 1 (2025): 12164. https://doi.org/10.55779/nsb17112164.

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Sickle Cell Disease (SCD) is genetic blood disorder due to which red blood cells (RBCs) carry an abnormal hemoglobin (HbS) tend to polymerize in hypoxic condition and get sickled shape. In the present study, an anti-sickling and antioxidant potential have been evaluated for the first time in aqueous extracts of niger (Guizotia abyssinica (L.f. Cass.), Asteraceae), an edible oil-yielding crop majorly grown in sickle cell disease-prone areas. In vitro shoots and callus formation was achieved on MS + 1.0 mg L-1 BAP from leaf and internodes, respectively as source material. The reversal of sickle

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Dr., K. Chandra Sekhar M. S.* K. Sravana Lakshmi. "A Review Article on Recent Advances in The Pharmacological Diversification of Imidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1581–99. https://doi.org/10.5281/zenodo.15205082.

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Furan a five membered aromatic heterocyclic ring system with O present at 1st position made up of 4C and4 H atoms furan ring is a part of many natural productslikeFurano flavonoid, furanocoumarins, etc... Furan nucleus show several biological applications and also shows strong affinity for a range of receptorsfuran and its derivatives are used in synthesis of many novel drugs. The antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, anti-depressant, anti-anxiolytic, anti-Parkinson, anti-glaucoma, muscle-relaxant, anti-hypertensive, diuretics, anti-ulcer, anti-aging, anti-cancer,

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Uronnachi, Emmanuel, Michael Onyezebe, Sunday Nduka, and Chukwuebuka Umeyor. "Preliminary Evaluation of the Anti-sickling and Polymerization Time Rate of Aqueous Extracts of Beta Vulgaris (Beetroot) on Sickle Cell Disorder (In-vitro model)." Journal of Current Biomedical Research 2, no. 1 (2022): 1–9. http://dx.doi.org/10.54117/jcbr.v2i1.1.

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S Sickle cell disease is an autosomal recessive genetic haematological disorder. Therapeutic approaches involve symptomatic management using conventional pharmacologic agents and substances of plant origin. This work was aimed at evaluating the in-vitro anti-sickling and polymerisation time rate effects of aqueous extracts of Beta vulgaris(beetroot)on sickle cell disease. Aqueous extraction of the beetroot was carried out. Phytochemical tests were conducted. Blood samples were collected from sickle cell patients. Osmotic fragility test and percentage haemolysis in different concentrations of N

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Hairston, Jerod, Keon Combi, Altreisha Foster, Bak Kim, Victor R. Gordeuk, and Sergei Nekhai. "Non-Competitive Protein Phosphatase-1 Inhibitors Prevent Sickling of SS RBCs." Blood 114, no. 22 (2009): 4038. http://dx.doi.org/10.1182/blood.v114.22.4038.4038.

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Abstract Abstract 4038 Poster Board III-974 Protein phosphatase-1 (PP1) has been implicated in the regulation of KCC (K:Cl) transporters, which transport K+ and Cl- ions from red blood cells (RBCs) and in the setting of sickle cell disease may contribute to RBC dehydration and sickling. We have studied host cell protein phosphatase-1 (PP1) in the context of HIV-1 replication and designed novel small molecule non-competitive inhibitors of PP1 that are efficient in the inhibition of HIV-1 but not toxic for cultured cells. We analyzed the effect of our novel non-competitive PP1 inhibitors and the

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Ngbolua, K., Rafatro Herintsoa, Rakotoarimanana Hajatiana, et al. "In vitro Anti-erythrocyte Sickling Effect of Lunularic Acid of Natural Origin." International Blood Research & Reviews 4, no. 3 (2015): 1–6. http://dx.doi.org/10.9734/ibrr/2015/21718.

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Merrett, M., D. K. Stammers, R. D. White, R. Wootton, and G. Kneen. "Characterization of the binding of the anti-sickling compound, BW12C, to haemoglobin." Biochemical Journal 239, no. 2 (1986): 387–92. http://dx.doi.org/10.1042/bj2390387.

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The anti-sickling agent BW12C [Beddell, Goodford, Kneen, White, Wilkinson & Wootton (1984) Br. J. Pharmacol. 82, 397-407] was designed to left-shift the oxygen saturation curve of haemoglobin (HbA) by preferential binding to the oxy conformation at a single site between the terminal amino groups of the alpha-chains through Schiff's base formation, ionic and hydrophobic interactions. In the present work, Schiff's base linkages formed with [14C]BW12C were reduced with NaBH4 and the alpha- and beta-globin chains separated. Under oxy conditions at a molar ratio of 2:1, the covalently bound BW1

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Levasseur, Dana N., Thomas M. Ryan, Michael P. Reilly, Steven L. McCune, Toshio Asakura, and Tim M. Townes. "A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin." Journal of Biological Chemistry 279, no. 26 (2004): 27518–24. http://dx.doi.org/10.1074/jbc.m402578200.

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Onyegeme-O, B. M., E. B. Essien, and J. I. Esin. "Anti-sickling Properties of Aqueous Extracts of Dennettia tripetala and Physalis angulata." Asian Journal of Biological Sciences 12, no. 4 (2019): 772–78. http://dx.doi.org/10.3923/ajbs.2019.772.778.

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Ataga, K. I. "Research Presentation: A Phase Ib study of a potential anti-sickling agent." Int. Journal of Clinical Pharmacology and Therapeutics 41, no. 02 (2003): 90. http://dx.doi.org/10.5414/cpp41090.

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Tripathi, Vaibhav, Deepak K Dash, Anil Sahu, Rajnikant Panik, and Kaushlesh Mishra. "Comparative screening of anti-sickling reported and traditional herbs found in Chhattisgarh." International Journal of Pharmaceutical Chemistry and Analysis 6, no. 4 (2020): 88–94. http://dx.doi.org/10.18231/j.ijpca.2019.017.

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Karlsson, Stefan. "The first steps on the gene therapy pathway to anti-sickling success." Nature Medicine 6, no. 2 (2000): 139–40. http://dx.doi.org/10.1038/72227.

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