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Relevant bibliographies by topics / Anti-thrombotic Molecules

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Journal articles

Academic literature on the topic 'Anti-thrombotic Molecules'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Anti-thrombotic Molecules"

1

Péč, Martin Jozef, Jakub Benko, Jakub Jurica, et al. "The Anti-Thrombotic Effects of PCSK9 Inhibitors." Pharmaceuticals 16, no. 9 (2023): 1197. http://dx.doi.org/10.3390/ph16091197.

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Atherosclerosis is the primary process that underlies cardiovascular disease. The connection between LDL cholesterol and the formation of atherosclerotic plaques is established by solid evidence. PCSK9 inhibitors have proven to be a valuable and practical resource for lowering the LDL cholesterol of many patients in recent years. Their inhibitory effect on atherosclerosis progression seems to be driven not just by lipid metabolism modification but also by LDL-independent mechanisms. We review the effect of PCSK9 inhibitors on various mechanisms involving platelet activation, inflammation, endo

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2

De Meyer, Simon. "ADAMTS13, an Anti-thrombotic Protein: Evidence Outside of Thrombotic Thrombocytopenic Purpura." Blood 134, Supplement_1 (2019): SCI—41—SCI—41. http://dx.doi.org/10.1182/blood-2019-121114.

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von Willebrand factor (VWF) is a large multimeric plasma glycoprotein that plays a crucial role in hemostasis and thrombosis. VWF recruits platelets at sites of vascular injury by acting as a molecular bridge between circulating platelets and the site of injured or activated blood vessels. Biosynthesis of VWF is restricted to endothelial cells and megakaryocytes. Endothelial VWF is constitutively secreted into plasma and subendothelium, or is stored as "ultra-large" (UL)-VWF multimers in endothelial Weibel-Palade bodies. VWF produced in megakaryocytes is packaged as UL-VWF in the a-granules of

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3

Fuentes, Eduardo, and Iván Palomo. "Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules." Vascular Pharmacology 75 (December 2015): 1–6. http://dx.doi.org/10.1016/j.vph.2015.05.002.

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4

Muro, S., and V. Muzykantov. "Targeting of Antioxidant and Anti-Thrombotic Drugs to Endothelial Cell Adhesion Molecules." Current Pharmaceutical Design 11, no. 18 (2005): 2383–401. http://dx.doi.org/10.2174/1381612054367274.

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5

Zaki, Magdi E. A., Sami A. Al-Hussain, Vijay H. Masand, Manoj K. Sabnani, and Abdul Samad. "Mechanistic and Predictive QSAR Analysis of Diverse Molecules to Capture Salient and Hidden Pharmacophores for Anti-Thrombotic Activity." International Journal of Molecular Sciences 22, no. 15 (2021): 8352. http://dx.doi.org/10.3390/ijms22158352.

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Thrombosis is a life-threatening disease with a high mortality rate in many countries. Even though anti-thrombotic drugs are available, their serious side effects compel the search for safer drugs. In search of a safer anti-thrombotic drug, Quantitative Structure-Activity Relationship (QSAR) could be useful to identify crucial pharmacophoric features. The present work is based on a larger data set comprising 1121 diverse compounds to develop a QSAR model having a balance of acceptable predictive ability (Predictive QSAR) and mechanistic interpretation (Mechanistic QSAR). The developed six para

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6

Shiels, Katie, Alexandros Tsoupras, Ronan Lordan, et al. "Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities." Marine Drugs 19, no. 1 (2021): 28. http://dx.doi.org/10.3390/md19010028.

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Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All test

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7

Shiels, Katie, Alexandros Tsoupras, Ronan Lordan, et al. "Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-thrombotic Activities." Marine Drugs 19, no. 1 (2021): 28. http://dx.doi.org/10.3390/md19010028.

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Abstract:

Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All test

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8

Clemetson, Jeannine, and Kenneth Clemetson. "Platelet GPIb complex as a target for anti-thrombotic drug development." Thrombosis and Haemostasis 99, no. 03 (2008): 473–79. http://dx.doi.org/10.1160/th07-12-0718.

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SummarySpecific inhibition of platelet function is a major target of antithrombotic drug research. Platelet receptors are both accessible and specific but have multiple functions often linked to a wide range of ligands. GPIb complex is best known as a major platelet receptor for vonWillebrand factor essential for platelet adhesion under high shear conditions found in arteries and in thrombosis. Recent animal studies have supported inhibition of GPIb as a good candidate for anti-thrombotic drug development with several classes of proteins showing important specific effects and the required disc

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9

Bălașa, Adrian Florian, Cristina Chircov, and Alexandru Mihai Grumezescu. "Marine Biocompounds for Neuroprotection—A Review." Marine Drugs 18, no. 6 (2020): 290. http://dx.doi.org/10.3390/md18060290.

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While terrestrial organisms are the primary source of natural products, recent years have witnessed a considerable shift towards marine-sourced biocompounds. They have achieved a great scientific interest due to the plethora of compounds with structural and chemical properties generally not found in terrestrial products, exhibiting significant bioactivity ten times higher than terrestrial-sourced molecules. In addition to the antioxidant, anti-thrombotic, anti-coagulant, anti-inflammatory, anti-proliferative, anti-hypertensive, anti-diabetic, and cardio-protection properties, marine-sourced bi

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10

Lopez, Jose J., Mohammed El Haouari, Isaac Jardin, et al. "Flavonoids and Platelet-Derived Thrombotic Disorders." Current Medicinal Chemistry 26, no. 39 (2019): 7035–47. http://dx.doi.org/10.2174/0929867325666180417170218.

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: Thrombotic disorders are characterized by an increase in the probability of the formation of unnecessary thrombi that might be due to the activation of the coagulation cascade or the circulating platelets. Platelets or thrombocytes play an essential role in hemostasis but abnormal platelet function leads to the development of a number of cardiovascular complications, including thrombotic disorders. Under pathological conditions, platelets are associated with the development of different thrombotic disorders, including atherosclerosis, arterial thrombosis and stroke, deep venous thrombosis an

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