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Journal articles on the topic 'Anti-Ulcer drugs'

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1

GANE, E., MM SUTTON, J. PYBUS, and I. HAMILTON. "PEPTIC ULCER: PATHOGENSIS, HEALING AND ANTI-ULCER DRUGS." Journal of Gastroenterology and Hepatology 11, no. 10 (1996): 911–15. http://dx.doi.org/10.1111/j.1440-1746.1996.tb00272.x.

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2

KIMURA, KEN, KENICHI IDO, YUSHI TANIGUCHI, et al. "PEPTIC ULCER: PATHOGENESIS, HEALING AND ANTI-ULCER DRUGS." Journal of Gastroenterology and Hepatology 11, no. 10 (1996): 916–21. http://dx.doi.org/10.1111/j.1440-1746.1996.tb00273.x.

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3

GYÖMBER, E., P. VATTAY, S. SZABO, and KD RAINSFORD. "PEPTIC ULCER: PATHOGENESIS, HEALING AND ANTI-ULCER DRUGS." Journal of Gastroenterology and Hepatology 11, no. 10 (1996): 922–27. http://dx.doi.org/10.1111/j.1440-1746.1996.tb00274.x.

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4

TERASAKI, TEIICHI, KAZUHIKO SHIMADA, HIROYUKI WAKABAYASHI, MICHIO TANAKA, and AKIHARU WATANABE. "PEPTIC ULCER: PATHOGENESIS, HEALING AND ANTI-ULCER DRUGS." Journal of Gastroenterology and Hepatology 11, no. 10 (1996): 928–37. http://dx.doi.org/10.1111/j.1440-1746.1996.tb00275.x.

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5

CARLI, Diego Michelon de, Rafael Cardoso PIRES, Sofia Laura ROHDE, Caroline Mayara KAVALCO, and Renato Borges FAGUNDES. "PEPTIC ULCER FREQUENCY DIFFERENCES RELATED TO H. PYLORI OR AINES." Arquivos de Gastroenterologia 52, no. 1 (2015): 46–49. http://dx.doi.org/10.1590/s0004-28032015000100010.

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Background Peptic ulcer etiology has been changing because of H. pylori decline. Objectives To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. Methods Records assessment in two periods: A (1997-2000) and B (2007-2010), searching for peptic ulcer, H. pylori infection and non-steroidal anti-inflammatory drugs use. Results Peptic ulcer occurred in 30.35% in A and in 20.19% in B. H. pylori infection occurred in 73.3% cases in A and in 46.4% in B. Non-steroidal anti-inflammatory drugs use was 3.5% in
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6

Whittle, Brendan J. R., and Andrew Garner. "New targets for anti-ulcer drugs." Trends in Pharmacological Sciences 9, no. 6 (1988): 188–89. http://dx.doi.org/10.1016/0165-6147(88)90075-2.

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7

Gede Komang Aditya, I. "Duodenal Ulcer in Osteoarthritis Patient Using Non Steroidal Anti Inflammatory Drugs." International Journal of Science and Research (IJSR) 7, no. 7 (2018): 393–96. https://doi.org/10.21275/art20183856.

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8

Ene, M. D., C. Jones, and C. J. C. Roberts. "Anti-ulcer drugs and intrinsic factor secretion." Scandinavian Journal of Gastroenterology 21, sup124 (1986): 137–43. http://dx.doi.org/10.3109/00365528609093795.

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9

Negro, Roberto Dal. "Pharmacokinetic Drug Interactions with Anti-Ulcer Drugs." Clinical Pharmacokinetics 35, no. 2 (1998): 135–50. http://dx.doi.org/10.2165/00003088-199835020-00003.

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10

Masi, Alfonse T. "Nonsteroidal Anti-Inflammatory Drugs and Peptic Ulcer." Annals of Internal Medicine 110, no. 3 (1989): 246. http://dx.doi.org/10.7326/0003-4819-110-3-246.

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11

Langman, Michael J. S. "Ulcer complications and nonsteroidal anti-inflammatory drugs." American Journal of Medicine 84, no. 2 (1988): 15–19. http://dx.doi.org/10.1016/0002-9343(88)90249-5.

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12

Dr., G. Usha kiran, P.Supriya, Naga Anjani V., Jeevan kumar P., Jasmin Sk., and Sai siva teja M. "Comparitive Evaluation of Different Anti-Ulcer Drugs using Standard Procedures." International Journal of Innovative Science and Research Technology 7, no. 12 (2023): 1736–45. https://doi.org/10.5281/zenodo.7537954.

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Ulcer is a common gastro intestinal disorder. It is fundamentally a kindled break in skin on the mucous film coating the wholesome lot. Ulceration happens when there is an unsettling influence in the typical balance brought about by either improved hostility (or) lessened mucosal obstruction. Ulcers are most common on the skin of the lower extremities and in the gastro intestinal tract, although they may be encountered at almost any site. Peptic ulcers are erosion lining of the stomach. Generally, pain occurs when the stomach is empty and relives after eating. A duodenal ulcer is most common i
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13

Deshpande, Mangirish, Pearl Dighe, and Sujit Nagare. "A Review of Antiulcer Activity of Some Medicinal Plants." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 201–13. http://dx.doi.org/10.22270/jddt.v14i8.6722.

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Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from
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14

&NA;. "Association between anti-ulcer drugs and liver injury." Reactions Weekly &NA;, no. 642 (1997): 5. http://dx.doi.org/10.2165/00128415-199706420-00010.

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15

Soll, Andrew H. "Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease." Annals of Internal Medicine 114, no. 4 (1991): 307. http://dx.doi.org/10.7326/0003-4819-114-4-307.

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16

Silverstein, Fred. "Nonsteroidal anti-inflammatory drugs and peptic ulcer disease." Postgraduate Medicine 89, no. 7 (1991): 33–40. http://dx.doi.org/10.1080/00325481.1991.11700937.

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17

Travis, J. "Surprising new target found for anti-ulcer drugs." Science 258, no. 5088 (1992): 1579. http://dx.doi.org/10.1126/science.1333641.

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18

Collier, D. St J., and J. A. Pain. "Anti-inflammatory drugs and upper gastrointestinal ulcer perforation." Clinical Rheumatology 4, no. 4 (1985): 389–91. http://dx.doi.org/10.1007/bf02031889.

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19

Murzabaeva, Elvira, and Isabek Ismailov. "MARKETING ASSESSMENT OF DRUGS USED FOR TREATMENT OF ACID-RELATED DISEASES IN BISHKEK." Avicenna Bulletin 22, no. 1 (2020): 67–73. http://dx.doi.org/10.25005/2074-0581-2020-22-1-67-73.

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Objective: Marketing assessment of anti-ulcer medicines in pharmacies in Bishkek. Methods: The study was used by data from the Department of Medicines and Medical Technology at the Ministry of Health of the Kyrgyz Republic on the registration of pharmaceutical products in the KR – State Registry of Medicines and Medical Products of 2019, as well as price sheets and invoices of wholesale pharmaceutical companies and retail pharmacies in Bishkek. Results: Depending on the value of the turnover rate (TR), the drugs were divided into three groups: drugs with slow TR (0.5 < К < 1.0); drugs wi
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20

Paikrao, Mr Bhushan Sambhaji, Dr Abhijeet Raosaheb Shete, and Dr Megha T. Salve. "Formulation & Evalution of entric coated tablets of anti- ulcer drugs of Pantaprazole." International Journal of Research Publication and Reviews 6, no. 5 (2025): 13509–17. https://doi.org/10.55248/gengpi.6.0525.1925.

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21

John Umaru, Isaac. "Peptic Ulcer Disease and Its Implications." Research of Gastric Management and Hepatology 1, no. 1 (2023): 01–04. http://dx.doi.org/10.58489/2836-6204/004.

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Peptic ulcer disease (PUD) is one of the commonest diseases seen throughout the world. Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. The most common symptom of a peptic ulcer is stomach pain. There are various risk factors for the development of peptic ulcer disease, but the most important ones are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients generally present with dyspepsia or peptic ulcer bleeding. Acid suppressant therapy, H. pylori eradication, and avoidance of nonst
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22

PAGUIGAN, Noemi D., Darryl Hannah B. CASTILLO, and Christine L. CHICHIOCO-HERNANDEZ. "ANTI-ULCER ACTIVITY OF LEGUMINOSAE PLANTS." Arquivos de Gastroenterologia 51, no. 1 (2014): 64–67. http://dx.doi.org/10.1590/s0004-28032014000100013.

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Context Ulcer is the most common gastrointestinal disturbance resulting from an inadequate gastric mucosal defense. Several drugs are available in the market to address the disease; however, these drugs are associated with unnecessary side effects. Objectives Previous research have confirmed the efficacy of plant extracts for possible treatment of the disease. This research aims to evaluate the anti-ulcer properties of medicinal plants. Methods Methanol extracts from the leaves of Intsia bijuga, Cynometra ramiflora, Tamarindus indica, Cassia javanica, Cassia fistula, Bauhini purpurea, Senna sp
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23

Mirzachan, Mirzaliev, Kononenko Nadiia, and Chikitkina Valentina. "Study of the antiulcer activity of dry extract of garden cabbage on a model of subchronic gastric ulcer." ScienceRise: Pharmaceutical Science, no. 4(20) (August 31, 2019): 4–9. https://doi.org/10.15587/2519-4852.2019.177612.

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<strong>Aim&nbsp;</strong>&ndash; to study the gastroprotective properties of dry cabbage garden extract on the model of experimental lesions of the gastric mucosa with acetylsalicylic acid. <strong>Materials and methods.</strong>&nbsp;Subchronic ulcerative lesions of the gastric mucosa of rats were simulated by intragastric administration of acetylsalicylic acid at a dose of 150 mg/kg for 3 days. Dry cabbage extract in a conditional therapeutic dose of 50 mg/kg and the comparison drugs omeprazole and altan were administered daily during the reproduction of the pathology and for another 2 days
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24

Christophe Mezui, Gustave Lebeau Ndji Otto, Lorraine Nkouendazem Ngueke, Joseph Fleurie Emakoua, Rosalie Armelle Ambassa Mbang, and Paul Vernyuy Tan. "Antiulcer activity of the stem bark aqueous extract of Croton oligandrum (Euphorbiaceae) against Ethanol/HCl-induced gastric mucosal injury in rats." World Journal of Biological and Pharmaceutical Research 5, no. 2 (2023): 023–30. http://dx.doi.org/10.53346/wjbpr.2023.5.2.0073.

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Gastric ulcer is an alteration of the lining of the stomach with destruction of mucus-producing cells. Many factors are contributing to the development of peptic ulcer such as phygiological stress, high production of acid, non-steroidal anti-inflammatory drugs (NSAIDs) and alcohol consumption. Croton oligandrum is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the cytoprotective activity of Croton oligandrum. To assess the gastroprotective potential of Croton oligandrum ulcer models were established using ethanol and indomethacin. Sucralfate
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25

Javed, Muhammad Ahsan, Mahtab Ahmad Khan, Haroon Arshad, et al. "Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer." RADS Journal of Pharmacy and Pharmaceutical Sciences 8, no. 1 (2020): 47–57. http://dx.doi.org/10.37962/jpps.v8i1.361.

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Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear.&#x0D; Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer.&#x0D; Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. Omeprazole and ra
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26

Rai, Nishant, Navin Kumar, Pankaj Gautam, and Pramod Rawat. "Herbal plants as potent candidate for Anti-ulcer drug development." Environment Conservation Journal 13, no. 1&2 (2012): 187–89. http://dx.doi.org/10.36953/ecj.2012.131235.

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Peptic ulcer is a common disorder that affects the lives of millions of people every year. The predominant causes of peptic ulcer are infection with the bacterium called Helicobacter pylori (H. pylori) and the use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Chemical drugs used in the treatment of peptic ulcer produces side effects on long term use. Extensive research has been carried out in the area of treatment of ulcers through medicinal plants. Many medicinal plants have been reported to possess antiulcer activity. Effective plant extracts, screened by cytotoxic, genotoxic, toxicologi
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27

Janićijević-Hudomal, S., D. Dekanski, and J. Rašić. "EFFICACY OF PLANT KINGDOM ON STRESS - ULCER DEVELOPING." Praxis medica 35, no. 2 (2007): 85–88. http://dx.doi.org/10.70949/pramed200702207j.

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&amp;lt;p&amp;gt;Despite progress in conventional pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies. Botanical compounds with anti-ulcer activity include flavonoids(i.e.quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). This article reviews the gastro-prot
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28

Onwudiwe, Tharcitus Chilaka, Prince Chiazor Unekwe, Kingsley Chimsorom Chilaka, Cajetan Elochukwu Ilo, Godwin Christian Akuodor, and Samuel Kelechi Mobisson. "Assessment of Gastric Acid Anti-Secretory Effects of Fraction Extracts of Piper guineense Leaf on Histamine-Induced Gastric Ulcer in Wistar Rats." Journal of Pharmaceutical Research 21, no. 1 (2022): 6–12. http://dx.doi.org/10.18579/jopcr/v21i1.ms22.31.

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Despite many etiological factors, gastric acid secretion is assumed to play a central role in the development of gastric ulcer. Blockade of gastric acid secretion therefore, seems to be the key therapeutic objective of gastric ulcer disease. Available acid-blocking/anti-secretory drugs used in the management of gastric ulcer are associated with high cost, unwanted side effects and treatment relapse. Extracts from plants can be useful and may serve as an alternative to conventional drugs in gastric ulcer management. This work was aimed at assessing the gastric acid anti-secretory effects of fra
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29

Drina, Musa. "Peptic ulcer disease and non-steroidal anti-inflammatory drugs." Australian Prescriber 40, no. 3 (2017): 91–93. http://dx.doi.org/10.18773/austprescr.2017.037.

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30

Sakimura, Chika, Akemi Iwamoto, Nariyuki Yamane, Osamu Kimura, Ryuichi Hamazoe, and Yoko Murata. "Perforated Colon Ulcer induced by Nonsteroidal Anti-Inflammatory Drugs." Japanese Journal of Gastroenterological Surgery 41, no. 11 (2008): 1978–82. http://dx.doi.org/10.5833/jjgs.41.1978.

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31

Collier, D. S., and J. A. Pain. "Non-steroidal anti-inflammatory drugs and peptic ulcer perforation." Gut 26, no. 4 (1985): 359–63. http://dx.doi.org/10.1136/gut.26.4.359.

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32

Smedley, F. H., and T. Hickish. "Non-steroidal anti-inflammatory drugs and peptic ulcer perforation." Gut 27, no. 1 (1986): 114. http://dx.doi.org/10.1136/gut.27.1.114.

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33

Somerville, Kevin, Gail Faulkner, and Michael Langman. "NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER." Lancet 327, no. 8479 (1986): 462–64. http://dx.doi.org/10.1016/s0140-6736(86)92927-2.

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34

Jick, SusanS, DavidR Perera, AlexanderM Walker, and Hershel Jick. "NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND PERFORATED PEPTIC ULCER." Lancet 330, no. 8572 (1987): 1398. http://dx.doi.org/10.1016/s0140-6736(87)91286-4.

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35

Collier, D. St J., J. A. Pain, SusanS Jick, et al. "NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND PERFORATED PEPTIC ULCER." Lancet 330, no. 8565 (1987): 968. http://dx.doi.org/10.1016/s0140-6736(87)91447-4.

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36

House, Tyler, та Patrick D. Webb. "Bleeding Zenkerʼs Diverticulum Ulcer from Nonsteroidal Anti-Inflammatory Drugs". ACG Case Reports Journal 3, № 1 (2016): e148. http://dx.doi.org/10.14309/crj.2016.121.

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37

Kondo, Isamu, and Masashl Yamaguchi. "Morphological changes of Helicobacter pylori caused in vitro by cytoprotective anti-ulcer drug, Sofalcone." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 620–21. http://dx.doi.org/10.1017/s0424820100160650.

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Since Helicobacter pylori has recently been regarded as a possible causative agent of a chronic gastritis and a peptic ulcer disease, the susceptibilities of this organism to anti-ulcer agents or antibiotics have attracted much interest of not only clinical docters but also medicobiologists.We have reported that Sofalcone, a cytoprotective anti-ulcer drug, has anti-bacterial and bactericidal activity as well as TDS (tripotassium dicitrats bithmuthate) and Clarithromycin (a derivative of erythromycin), but the other anti-ulcer drugs Including anti-acid or H2 receptor antagonists such as cimetid
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38

Panda, Vandana, and Madhav Sonkamble. "Anti-ulcer activity of Ipomoea batatas tubers (sweet potato)." Functional Foods in Health and Disease 2, no. 3 (2012): 48. http://dx.doi.org/10.31989/ffhd.v2i3.99.

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Background: Peptic ulcers occur in that part of the gastrointestinal tract which is exposed to gastric acid and pepsin, i.e., the stomach and duodenum. Gastric and duodenal ulcers are common pathologies that may be induced by a variety of factors such as stress, smoking and noxious agents including non-steroidal anti-inflammatory drugs. Ipomoea batatas tubers (sweet potato) contain ample amounts of antioxidants. It has been proven already by many scientific studies that antioxidants have ulcer healing properties. In reference to this, we tried assessing the ulcer healing effect of Ipomoea bata
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39

Dong, Siyuan, Xudong Wang, Yixin Liu, et al. "A novel gastric ulcer model in rats using filter paper with acetic acid." PLOS ONE 20, no. 4 (2025): e0319096. https://doi.org/10.1371/journal.pone.0319096.

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Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed
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40

Balmik, Mithun, Gaurav Dubey, Sailesh Kumar Ghauary, and Prabhat Kumar Jain. "Phytochemical Screening and Evaluation of Antiulcer Activity of Hydroalcoholic Extract of Lilium Candidum Flowers." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 646–50. http://dx.doi.org/10.22270/jddt.v9i4-a.3545.

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Peptic disorders like gastro esophageal reflux disease, gastritis, peptic ulcer, duodenal ulcer etc., are the common in today’s life style. This may be due to stressful life style or improper balance diet. The pathology behind these disorders may be discrepancy between offensive and defensive mechanisms either by excess secretion of acid and pepsin or diminished ability of the gastro-duodenal mucosal barrier to protect against stomach acid-pepsin secretion. Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain diso
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Langman, MJS. "The Assessment of Evidence Associating Nonsteroidal Anti-Inflammatory Drugs with Complications of Peptic Ulcerations." Canadian Journal of Gastroenterology 4, no. 3 (1990): 91–94. http://dx.doi.org/10.1155/1990/728604.

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A causal relationship is now firmly established between nonsteroidal anti-inflammatory drug (NSAlD) use and the occurrence of peptic ulcer complications. In the United Kingdom, rising NSAID use has been matched by rises in ulcer mortality and perforation rates, particularly in older women. It is not likely, however, that drug use accounts for the entire increase. The reasons why some people develop ulcer complications and others do not are poorly understood. It is plausible to propose that other factors, such as history of ulcer or indigestion, current smoking, and alcohol consumption, might r
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42

Pattewar, S.G. Sakhare R. S. Nagoba Shivappa N. Sugave B. K. Moholkar Aparark V. "A REVIEW: TRADITIONAL ANTIULCER COMPOUNDS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 911–17. https://doi.org/10.5281/zenodo.2538342.

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<em>Peptic ulcer is a break in the lining of the stomach, first part of the small intestine, or duodenum. The duodenumis the first part of the small intestine. Incompatible to popular belief, ulcers are not caused by spicy food or stress but other factors causes&rsquo; peptic ulcer main cause of peptic ulcer called H. pylori bacterial infection and long term use of NSAIDS medication. The main goals for treating a peptic ulcer include eliminating the underlying cause (particularly H. pylori infection or use of NSAIDs), NSAIDs inhibit the cyclooxygenase enzyme, Cyclooxygenase stop the secretion
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43

DIACONESCU, Smaranda, Marin BURLEA, Raluca STANCA, Monica ALEXOAE, and Ileana IONIUC. "Triple gastric ulcer in young child – case presentation." Romanian Journal of Medical Practice 10, no. 4 (2015): 394–96. http://dx.doi.org/10.37897/rjmp.2015.4.14.

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Peptic ulcer is represented by loss of gastric or duodenal mucosal substance. It’s been considered a rare disease at the paediatric age. The main cause is represented by Helicobacter pylori infections or drugs administration. The authors present a case of nine-year-old child with triple gastric ulcer without Helicobacter pylori infection or prior treatment with nonsteroidal anti-inflammatory drugs or other medication with possible impact.
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44

Wallace, John L. "The 1994 Merck Frosst Award. Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage—potential for development of gastrointestinal tract safe NSAIDs." Canadian Journal of Physiology and Pharmacology 72, no. 12 (1994): 1493–98. http://dx.doi.org/10.1139/y94-215.

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Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permit the rational design of anti-inflammatory drugs that spare the gastrointestinal tract. In this review, the mechanisms through which nonsteroidal anti-inflammatory drugs are believed to cause gastrointestinal ulceration are reviewed. Several strategies that are being employed to d
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45

S. SENTHILKUMAR, P. KUMAR SINGH, and C. KIRUBA RANI. "Pharmacological evaluation of the anti-ulcer and anti-arthritic potential of ethanolic extract of acalypha indica linn." World Journal of Biology Pharmacy and Health Sciences 22, no. 2 (2025): 147–54. https://doi.org/10.30574/wjbphs.2025.22.2.0471.

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The objective of present study to evaluate the anti-ulcer and anti-arthritic activity of ethanolic leaf extract of Acalypha indica. The anti-ulcer activity of ethanolic extract of Acalypha indica was investigated by pylorous ligation and indomethacin induced gastric ulcer in rats. The cause of ulceration in patients is mainly due to hyper secretion of gastric acid and pepsin. Acalypha indica plant extract some of the most attractive sources of new drugs and have been shown to produce promising results in the treatment of gastric ulcers. Rheumatoid arthritis is a systemic auto immune disease ch
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46

Hassan, Ghaneya S., Gehan H. Hegazy, Noha M. Ibrahim, and Samar H. Fahim. "New ibuprofen derivatives as H2S and NO donors as safer anti-inflammatory agents." Future Medicinal Chemistry 11, no. 23 (2019): 3029–45. http://dx.doi.org/10.4155/fmc-2018-0467.

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Aim: Nonsteroidal anti-inflammatory drugs are expansively used worldwide. However, their prolonged administration is associated with serious side effects, especially gastrointestinal ulceration. Materials &amp; methods: New ibuprofen derivatives hybridized with H2S- or NO-donating moieties were synthesized and evaluated for their anti-inflammatory activity and ulcerogenic effect. COX-1/COX-2 isozymes selectivity test for the most promising derivatives was performed. Molecular docking studies were performed. Results: Most of the compounds showed promising anti-inflammatory activity comparable t
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LANGMAN, M. J. S. "Ulcer and ulcer complications from non-steroidal anti-inflammatory drugs: what is the risk?" Alimentary Pharmacology & Therapeutics 2 (March 31, 2007): 27–31. http://dx.doi.org/10.1111/j.1365-2036.1988.tb00762.x.

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Alka Zade, Jugalkishore Vyas, Vivek Paithankar, and Anjali Wankhede. "Evaluation of antiulcer activity of herbal drugs on experimental animal: Myrica nagi (Myricaceae)." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 138–44. http://dx.doi.org/10.30574/gscbps.2022.20.2.0326.

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The anti-ulcer activity of Methanolic extract of Myrica nagi (Myricaceae) fruit MEMN was investigated in pylorus ligation and methanol-induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index MEMN at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Aspirin-induced ulcers &amp; pylorus ligation-induced ulcers. The extract (200, 400 mg/kg) showed a significant (P &lt; 0.001) reduction in gastric volume, free acidity and ulcer index as compared to the control. This present study indicates that Myrica nagi frui
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Elbaramawi, Samar S., Mohamed E. El-Sadek, Mohamed M. Baraka, Lobna M. Abdel-Aziz, and Mahmoud Mohammed Sebaiy. "Instrumental analysis of some anti-ulcer drugs in different matrices." Chemical Reports 2, no. 1 (2020): 156–72. http://dx.doi.org/10.25082/cr.2020.01.005.

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In this literature review, we will introduce most reported methods that have been developed for determination of certain anti-ulcer drugs such as Ranitidine hydrochloride, Famotidine, Omeprazole, Pantoprazole sodium, Tinidazole and Doxycycline hyclate in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples.
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G., Ranjani*1 A. Vasanthan2 K. L. Senthil kumar3. "Development And Evaluation Of Bilayer Floating Tablet For Helicobacter Pyloric Induced Ulcer Treatment Using Omeprazole And Tinidazole." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 724–43. https://doi.org/10.5281/zenodo.13926394.

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Development and evaluation of bilayer floating tablet containing ulcer and antibiotic drugs. This study aims to develop a bilayer tablet containing an anti-ulcer and anti-antibiotic combination, with omeprazole as the immediate release layer and tinidazole as the sustained release layer, and to conduct in vitro release studies of the formulation. The combination of these drugs, which have complementary mechanisms of action, is intended to achieve a fixed dose, improve patient compliance, optimize formulation that enhances safety, and increase the therapeutic efficacy of the drugs. Several meth
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