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Journal articles on the topic 'Antiamoebic activity'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

D., R. SHRIDHAR, V. REDDY SASTRY C., K. MARWAH A., PADMA PARIHAR (Miss), and B. LAL K. "Synthesis and Biological Activity of some New 2-(Heteroaryl)vinylsulphonyl Derivatives." Journal of Indian Chemical Society Vol. 62, Jul 1985 (1985): 537–40. https://doi.org/10.5281/zenodo.6321942.

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Chemistry Division, IDPL Research Centre, Indian Drugs and Pharmaceuticals Limited, Hyderabad-500 037 <em>Manuscript received 26 December 1984, accepted 31 July 1985</em> Several new 2-[(5 nitro-t-methyl-2-imldazolyl-, 5-nltro-2-furyl·, and 5-nitro-2- thienyl)vinyl)-<em>N</em>-arylsulpbonamides and sulphonyl heterocycles (1 and 2) have been prepared and screened for their \(in\) \(vitro\) antibacterial, antifungal, antiamoeblc, antitrlchomonal and \(in\) \(vivo\) anthelmintic activities, against a variety of microorganisms. Some of the compounds possess promising antibacterial

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2

Lê, Hương Giang, Tuấn Cường Võ, Jung-Mi Kang, et al. "Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species." Parasites, Hosts and Diseases 61, no. 4 (2023): 449–54. http://dx.doi.org/10.3347/phd.23078.

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Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the an

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3

Lakshmi, Vijai, and Sheela Ghosal. "Antiamoebic Activity of Marine Sponge Spongia officinalis var. ceylonensis Dendy." Bangladesh Pharmaceutical Journal 17, no. 1 (2015): 38–42. http://dx.doi.org/10.3329/bpj.v17i1.22312.

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Human amoebiasis due to infection by Entamoeba histolytica is mainly associated with morbidity thus affecting the quality of life and pace of developmental activities of countries with warm climatic conditions. A consistently high global incidence of this disease has been reported. In an endeavor to identify novel molecules with potent antiamoebic activity and lower side-effect, the present study was designed to investigate antiamoebic activity in Spongia officinalis extracts/fractions followed by isolation and characterization of bioactive molecules. The methanol extract of the S. officinalis

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Akbar, Noor, Mohammed I. El-Gamal, Balsam Qubais Saeed, et al. "Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii." Antibiotics 11, no. 9 (2022): 1183. http://dx.doi.org/10.3390/antibiotics11091183.

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We examined the antiamoebic effect of several imidazothiazole derivatives on Acanthamoeba castellanii of the T4 genotype. Trypan blue exclusion assays and haemocytometer counting were used to determine the reduction in A. castellanii trophozoite proliferation, in response to treatment with these compounds. To determine the effects of these compounds on host cells, lactate dehydrogenase assay was performed using HeLa cell lines. Amoebicidal assays revealed that the tested compounds at concentrations of 50 µM significantly inhibited amoebae trophozoites compared to controls. Compounds 1m and 1zb

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5

Calzada, Fernando, Mariana Meckes, and Roberto Cedillo-Rivera. "Antiamoebic and Antigiardial Activity of Plant Flavonoids**." Planta Medica 65, no. 01 (1999): 78–80. http://dx.doi.org/10.1055/s-2006-960445.

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6

Calzada, Fernando, Elizabeth Barbosa, and Roberto Cedillo-Rivera. "Antiamoebic activity of benzyl glucosinolate fromLepidium virginicum." Phytotherapy Research 17, no. 6 (2003): 618–19. http://dx.doi.org/10.1002/ptr.1210.

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7

Bhutani, K., G. Sharma, and Mohd Ali. "Plant Based Antiamoebic Drugs; Part I. Antiamoebic Activity of Phenanthroindolizidine Alkaloids; Common Structural Determinants of Activity with Emetine." Planta Medica 53, no. 06 (1987): 532–36. http://dx.doi.org/10.1055/s-2006-962803.

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8

Wani, Mohmmad Younus, Abdul Roouf Bhat, Amir Azam, Fareeda Athar, and Abilio J. F. N. Sobral. "New transition metal complexes containing imidazole rings endowed with potential antiamoebic activity." MedChemComm 7, no. 5 (2016): 982–89. http://dx.doi.org/10.1039/c6md00013d.

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Imidazole-hydrazones were found to be better antiamoebic lead molecules compared to the standard drug metronidazole (MNZ). Chelation of these bioactive ligands with metals enhanced their activity profiles.

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La Kilo, Akram, La Ode Aman, Ismail Sabihi, and Jafar La Kilo. "Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico." Indo. J. Chem. Res. 7, no. 1 (2019): 9–24. http://dx.doi.org/10.30598//ijcr.2019.7-akr.

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This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear

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La Kilo, Akram, La Ode Aman, Ismail Sabihi, and Jafar La Kilo. "Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico." Indonesian Journal of Chemical Research 7, no. 1 (2019): 9–24. http://dx.doi.org/10.30598/ijcr.2019.7-akr.

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This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear

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11

Sharma, Poonam, and Jayashri Devi Sharma. "A review of plant species assessedin?vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties." Phytotherapy Research 15, no. 1 (2001): 1–17. http://dx.doi.org/10.1002/1099-1573(200102)15:1<1::aid-ptr959>3.0.co;2-l.

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12

Cimanga, Kanyanga, Kabangu Kambu, Lutete Tona, et al. "Antiamoebic Activity of Iridoids from Morinda morindoides Leaves." Planta Medica 72, no. 8 (2006): 751–53. http://dx.doi.org/10.1055/s-2006-931581.

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13

Abid, Mohammad, Subhash M. Agarwal, and Amir Azam. "Synthesis and antiamoebic activity of metronidazole thiosemicarbazone analogues." European Journal of Medicinal Chemistry 43, no. 9 (2008): 2035–39. http://dx.doi.org/10.1016/j.ejmech.2007.12.007.

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14

Lakshmi, Vijai, and Sheela Ghosal. "In vitro and in vivo Antiamoebic Potential of Actinopyga lecanora (Jaeger)." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 118–20. http://dx.doi.org/10.3329/bpj.v18i2.24308.

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Human amoebiasis, due to Entamoeba histolytica infection, is mainly associated with morbidity thus affecting the quality of life and pace of development in the countries with warm climatic conditions. So far, the available drugs provide only symptomatic relief and they are not devoid of side effects. This leads to obtain novel molecules from natural sources having antiamoebic activity. The methanol extract of Actinopyga lecanora (Jaeger) displayed antiamoebic activity. It showed MIC 125 ?g/ml in our in-vitro studies, but when it was tested in rats, it revealed 88% inhibition of trophozoites at

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15

López-Vallejo, Fabian, Rafael Castillo, Lilián Yépez-Mulia, and José L. Medina-Franco. "Benzotriazoles and Indazoles Are Scaffolds with Biological Activity against Entamoeba histolytica." Journal of Biomolecular Screening 16, no. 8 (2011): 862–68. http://dx.doi.org/10.1177/1087057111414902.

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Parasitic infections caused by Entamoeba histolytica are still major threats against public health, especially in developing countries. Although current therapies exist, the problems associated with parasite resistance and negative side effects make it imperative to search for new therapeutic agents. A systematic scaffold analysis reported herein of a public database containing 474 antiamoebic compounds reveals that benzimidazole is the most active scaffold reported thus far. To gain insights into the antiamoebic activity of novel compounds, the authors report herein the biological activity of

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16

Manna, Dipak, Pradeep K. Dutta, Basudeb Achari, and Anuradha Lohia. "A Novel Galacto-Glycerolipid from Oxalis corniculata Kills Entamoeba histolytica and Giardia lamblia." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4825–32. http://dx.doi.org/10.1128/aac.00546-10.

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ABSTRACT Oxalis corniculata is a naturally occurring weed that has been used in traditional medicine for the cure of dysentery and diarrhea in India. One of the common causes of dysentery is due to infection by the protist pathogen Entamoeba histolytica. Bioactivity profiling of extracts from O. corniculata identified several compounds that showed antiamoebic activity in axenic cultures of E. histolytica. These were characterized by nuclear magnetic resonance, infrared, and mass spectrometry as (i) Oc-1, a mixture of saturated fatty acids C24 to C28; (ii) Oc-2, a mixture of long-chain alcohols

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17

KALYANAM, N., and S. G. MANJUNATHA. "ChemInform Abstract: Studies on Antiamoebic Compounds. Part 2. Antiamoebic Activity of Dichloroacetamides of 1,5-Benzodiazepinones and Tetrahydroquinoxalinones." ChemInform 23, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199205122.

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18

Sangsuwon, Chanyapat, and Weena Jirujchariyakul. "Development of Microemulsion of Phytosteryl Glycoside in DMSO and Tween 20 for Increase Antiamoebic Activity." Key Engineering Materials 675-676 (January 2016): 27–30. http://dx.doi.org/10.4028/www.scientific.net/kem.675-676.27.

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Peperomia pellucida (Piperaceae) of Thai name “Phak kra sang” is medicinal plant. They are eaten in a salad or as cooked vegetable for protected glaucoma, eye inflammation. Recently, The methanol fraction of P. pellucida was tested for antiamoebic effect. Acanthamoeba spp. are protozoa, free-living in the environment and feed on bacteria. Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis. P. pellucida is medicinal plants, and was interesting for studied antiamobic. The separation by column chromatography (CC) used organic solvent of methanol and ethyl acetate (3:7) gave phyt

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19

Mukhtar, Sayeed, Waleed Atef Manasreh, Humaira Parveen, and Amir Azam. "Synthesis, Characterization, Antiamoebic Activity and Toxicity of Ferrocenyl Chalcones." Asian Journal of Chemistry 26, no. 24 (2014): 8407–12. http://dx.doi.org/10.14233/ajchem.2014.17697.

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20

Singh, Shailendra, Neelam Bharti, Manoj Chugh, Fehmida Naqvi, and Amir Azam. "Activity of Extracts and Procesterol from Calotropis gigantea against Entamoeba histolytica." Natural Product Communications 5, no. 6 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500608.

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Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.

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21

Maliński, Michał P., Jaromir Budzianowski, Małgorzata Kikowska, et al. "Two Ecdysteroids Isolated from Micropropagated Lychnis flos-cuculi and the Biological Activity of Plant Material." Molecules 26, no. 4 (2021): 904. http://dx.doi.org/10.3390/molecules26040904.

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Genetically uniform plant material, derived from Lychnis flos-cuculi propagated in vitro, was used for the isolation of 20-hydroxyecdysone and polypodine B and subjected to an evaluation of the antifungal and antiamoebic activity. The activity of 80% aqueous methanolic extracts, their fractions, and isolated ecdysteroids were studied against pathogenic Acanthamoeba castellani. Additionally, a Microtox® acute toxicity assay was performed. It was found that an 80% methanolic fraction of root extract exerts the most potent amoebicidal activity at IC50 of 0.06 mg/mL at the 3rd day of treatment. Bo

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22

Quintanilla-Licea, Ramiro, Javier Vargas-Villarreal, María Julia Verde-Star, Verónica Mayela Rivas-Galindo, and Ángel David Torres-Hernández. "Antiprotozoal Activity Against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth." Molecules 25, no. 11 (2020): 2464. http://dx.doi.org/10.3390/molecules25112464.

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Amebiasis caused by Entamoeba histolytica is nowadays a serious public health problem worldwide, especially in developing countries. Annually, up to 100,000 deaths occur across the world. Due to the resistance that pathogenic protozoa exhibit against commercial antiprotozoal drugs, a growing emphasis has been placed on plants used in traditional medicine to discover new antiparasitics. Previously, we reported the in vitro antiamoebic activity of a methanolic extract of Lippia graveolens Kunth (Mexican oregano). In this study, we outline the isolation and structure elucidation of antiamoebic co

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23

Rassu, Giovanna, Elisabetta Gavini, Antonella Mattana, and Paolo Giunchedi. "Improvement of Antiamoebic Activity of Rokitamycin Loaded in Chitosan Microspheres." Open Drug Delivery Journal 2, no. 1 (2008): 38–43. http://dx.doi.org/10.2174/1874126600802010038.

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24

Chatterjee, D. K., N. Iyer, and B. N. Ganguli. "Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models." Parasitology Research 74, no. 1 (1987): 30–33. http://dx.doi.org/10.1007/bf00534928.

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25

Iqbal, Prince Firdoos, Humaira Parveen, Abdul Roouf Bhat, Faisal Hayat, and Amir Azam. "Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives." European Journal of Medicinal Chemistry 44, no. 11 (2009): 4747–51. http://dx.doi.org/10.1016/j.ejmech.2009.06.016.

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26

Rodrigues, Barbara Czerniak, Maria Luiza Carneiro Büchele, Carolina de Jesus de Camargo, Fabíola Branco Filippin-Monteiro, and Karin Silva Caumo. "In Vitro Stability of the Biological Activity of Voriconazole against Acanthamoeba castellanii." Parasitologia 3, no. 2 (2023): 194–204. http://dx.doi.org/10.3390/parasitologia3020020.

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Acanthamoeba keratitis (AK) is a rare cornea disease caused by species of the Acanthamoeba genus. The antifungal voriconazole blocks the ergosterol synthesis in the protozoan membrane and is active against the cysts and trophozoites of Acanthamoeba spp. Due to the low stability of voriconazole, its options for eye drops are scarce. This study aimed to investigate the stability of the biological activity of voriconazole against two strains of Acanthamoeba castellanii and one clinical isolate from a patient with AK. To evaluate the stability of the biological activity of voriconazole, strains of

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27

Cartuche, Luis, María Reyes-Batlle, Ines Sifaoui, et al. "Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures." Marine Drugs 17, no. 10 (2019): 588. http://dx.doi.org/10.3390/md17100588.

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Indolocarbazoles are a family of natural alkaloids characterized by their potent protein kinase and topoisomerase I inhibitory activity. Among them, staurosporine (1) has exhibited promising inhibitory activity against parasites. Based on new insights on the activity and mechanism of action of STS in Acanthamoeba parasites, this work reports the isolation, identification, and the anti-Acanthamoeba activity of the minor metabolites 7-oxostaurosporine (2), 4′-demethylamino-4′-oxostaurosporine (3), and streptocarbazole B (4), isolated from cultures of the mangrove strain Streptomyces sanyensis. A

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González-Fernández, Sara, Victor Lozano-Iturbe, Mª Fe Menéndez, et al. "A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP." Antibiotics 11, no. 8 (2022): 1054. http://dx.doi.org/10.3390/antibiotics11081054.

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Silver nanoparticles (AgNPs) play an important role in the medical field due to their potent antimicrobial activity. This, together with the constant emergence of resistance to antimicrobial drugs, means AgNPs are often investigated as an alternative to solve this problem. In this article, we analyzed the antifungal and antiamoebic effects of a recently described type of AgNP, silver nanorings (AgNRs), and compared them with other types of AgNPs. Tests of the activity of AgNPs against various fungal and amoebic species were carried out. In all cases, AgNPs showed a high biocidal effect, althou

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Zavala-Ocampo, Lizeth M., Eva Aguirre-Hernández, Nury P érez-Hernández, Gildardo Rivera, Laurence A. Marchat, and Esther Ramírez-Moreno. "Antiamoebic Activity of Petiveria alliacea Leaves and Their Main Component, Isoarborinol." Journal of Microbiology and Biotechnology 27, no. 8 (2017): 1401–8. http://dx.doi.org/10.4014/jmb.1705.05003.

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30

Journal, Baghdad Science. "Antiamoebic activity of extracted alkaloids of Capparis spinosa in Laboratory mice." Baghdad Science Journal 11, no. 2 (2014): 920–27. http://dx.doi.org/10.21123/bsj.11.2.920-927.

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The current study was concerned with the effect of alkaloid extract of the aerial parts of Capparis spinosa against Entamoeba histolytica and compared with drug Metronidazole in the laboratory mice .Stool samples were collected from people infected with maebiasis to infect laboratory mice . The alkaloid compounds were separated by thin chromatography technique (TLC) and identified by spectral methods represented by spectral infrared (IR) and altraviolate (UV) . the stady include determining mid-term lethal dose LD50 of the extract as the concentration was 21.65 g / kg . The effect dose of the

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31

S. Refaey, Mohamed, Reda Fouad Ahmed Abdelhameed, Eman A. A. Mousa, et al. "A New Iridoid Glucoside from Anisacanthus virgularis and Its Antiamoebic Activity." HETEROCYCLES 98, no. 9 (2019): 1229. http://dx.doi.org/10.3987/com-19-14102.

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32

Salahuddin, Attar, Subhash M. Agarwal, Fernando Avecilla, and Amir Azam. "Metronidazole thiosalicylate conjugates: Synthesis, crystal structure, docking studies and antiamoebic activity." Bioorganic & Medicinal Chemistry Letters 22, no. 17 (2012): 5694–99. http://dx.doi.org/10.1016/j.bmcl.2012.06.083.

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33

Negi, Beena, Prija Poonan, Mohammad Fawad Ansari, et al. "Synthesis, antiamoebic activity and docking studies of metronidazole-triazole-styryl hybrids." European Journal of Medicinal Chemistry 150 (April 2018): 633–41. http://dx.doi.org/10.1016/j.ejmech.2018.03.033.

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34

VENUGOPALAN, B., S. SURESH, P. J. KARNIK, N. J. DE SOUZA, D. K. CHATTERJEE, and S. N. IYER. "ChemInform Abstract: Synthesis and Antiamoebic Activity of 2,3-Diaryl-5,8- dimethoxyquinoxalines." ChemInform 22, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.199141175.

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35

Rakesh, Sharma, Tandon Rakesh, and S. Singh Vijay. "Nitroimidazole Triggers the DNA Synthesis in Kupffer Cells towards Liver Regeneration and Restoration." Journal of Advances in Clinical Pharmacology 3, no. 1 (2025): 18–25. https://doi.org/10.5281/zenodo.14928239.

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<em>Aim:</em><em> To evaluate the effect of nitroimidazole on isolated human Kupffer cells in cultures by using DNA synthesis activity as Kupffer cell biomarker with evidence of DNA synthesis regulatory behavior. </em> <em>Hypothesis:</em><em> Kupffer cell DNA synthesis activity may be a biomarker of antiamoebic cytotoxicity evaluation of nitroimidazole. </em> <em>Methods and Materials:</em><em> The selected liver biopsies from patients (ongoing amebic liver abscess research project) were processed for isolation and fractionation of Kupffer cells. Three groups of Kupffer cells were: untreated

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SHIRAI, AKIHIRO, TOSHIYUKI ENDO, HIDEAKI MASEDA, and TAKESHI OMASA. "Synthesis of Thiazole Derivatives and Evaluation of Their Antiamoebic Activity and Cytotoxicity." Biocontrol Science 18, no. 4 (2013): 183–91. http://dx.doi.org/10.4265/bio.18.183.

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Bharti, Neelam, Shailendra Singh, Fehmida Naqvi, and Amir Azam. "Isolation and in vitro antiamoebic activity of iridoids isolated from Kigelia pinnata." Arkivoc 2006, no. 10 (2006): 69–76. http://dx.doi.org/10.3998/ark.5550190.0007.a09.

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Leeza Zaidi, Saadia, Sonam Mittal, Maitreyi S. Rajala, Fernando Avecilla, Mohammad Husain, and Amir Azam. "Synthesis, characterization and antiamoebic activity of chalcones bearing N-substituted ethanamine tail." European Journal of Medicinal Chemistry 98 (June 2015): 179–89. http://dx.doi.org/10.1016/j.ejmech.2015.05.013.

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Negi, Beena, K. Kranthi Raj, Shadab Miyan Siddiqui, Dittakavi Ramachandran, Amir Azam, and Diwan S. Rawat. "In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole-Triazole Hybrids." ChemMedChem 9, no. 11 (2014): 2439–44. http://dx.doi.org/10.1002/cmdc.201402240.

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Siddiqui, Shadab Miyan, Attar Salahuddin, and Amir Azam. "Pyrazolo[3,4-d]pyrimidine analogues: synthesis, characterization and their in vitro antiamoebic activity." Medicinal Chemistry Research 22, no. 2 (2012): 775–81. http://dx.doi.org/10.1007/s00044-012-0070-6.

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Sharma, G., and K. Bhutani. "Plant Based Antiamoebic Drugs; Part II1. Amoebicidal Activity of Parthenin Isolated fromParthenium hysterophorus2." Planta Medica 54, no. 02 (1988): 120–22. http://dx.doi.org/10.1055/s-2006-962366.

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Makhlouf, Zinb, Noor Akbar, Naveed Ahmed Khan, et al. "Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone." Antibiotics 11, no. 12 (2022): 1721. http://dx.doi.org/10.3390/antibiotics11121721.

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Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent. Accordingly, there is a pressing need for novel compounds. Nanotechnology has been gaining attention for enhancing drug delivery and reducing toxicity. Previous work has shown that various antibiotic classes displayed antiamoebic activity. Herein, we employed two antibiotics: ampicillin and ceftriaxone, conjugated with the nanocarrier zinc oxide and β-cyclodextrin, and tested them against A. castellanii via am

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Bharti, Neelam, Shailendra, M. T. Gonzalez Garza, et al. "Synthesis, Characterization and Antiamoebic Activity of Benzimidazole Derivatives and Their Vanadium and Molybdenum Complexes." Bioorganic & Medicinal Chemistry Letters 12, no. 6 (2002): 869–71. http://dx.doi.org/10.1016/s0960-894x(02)00034-3.

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44

Ghoshal, Sheela, B. N. Krishna Prasad, and V. Lakshmi. "Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo." Journal of Ethnopharmacology 50, no. 3 (1996): 167–70. http://dx.doi.org/10.1016/0378-8741(96)01382-7.

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45

Shahbaz, Muhammad Saquib, Ayaz Anwar, Syed Muhammad Saad, et al. "Antiamoebic activity of 3-aryl-6,7-dimethoxyquinazolin-4(3H)-one library against Acanthamoeba castellanii." Parasitology Research 119, no. 7 (2020): 2327–35. http://dx.doi.org/10.1007/s00436-020-06710-7.

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Abid, Mohammad, Kakul Husain, and Amir Azam. "Synthesis and antiamoebic activity of new oxime ether derivatives containing 2-acetylpyridine/2-acetylfuran." Bioorganic & Medicinal Chemistry Letters 15, no. 19 (2005): 4375–79. http://dx.doi.org/10.1016/j.bmcl.2005.06.029.

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Singh, Pramod, Jagmohan S. Negi, M. S. M. Rawat, and Geeta Joshi nee Pant. "Synthesis, antiamoebic activity and thermal study of copper complexes of 1-formyl-2-pyrazolines." Journal of Thermal Analysis and Calorimetry 111, no. 1 (2012): 549–52. http://dx.doi.org/10.1007/s10973-011-2168-3.

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Bhat, Abdul R., Fareeda Athar, and Amir Azam. "Bis-pyrazolines: Synthesis, characterization and antiamoebic activity as inhibitors of growth of Entamoeba histolytica." European Journal of Medicinal Chemistry 44, no. 1 (2009): 426–31. http://dx.doi.org/10.1016/j.ejmech.2007.11.005.

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Macías-Pérez, José Roberto, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Martín Humberto Muñoz-Ortega, Julieta Pulido-Ortega та Javier Ventura-Juárez. "Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2/HO-1 and NF-κB/IL-1β Signaling Pathways". Journal of Immunology Research 2019 (15 квітня 2019): 1–10. http://dx.doi.org/10.1155/2019/7431652.

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Abstract:

Amoebic liver abscess (ALA) is the most common extraintestinal amoebiasis caused by Entamoeba histolytica (E. histolytica). However, despite current knowledge and scientific advances about this infection, there are no effective treatments to prevent it. Herein, the antiamoebic capacity of curcumin in a hamster model was evaluated. Curcumin (150 mg/kg, p.o., daily during 10 days before infection) considerably prevents liver damage induced at 12 and 48 h post-intrahepatic inoculation of trophozoites and decreases ALT, ALP, and γ-GTP activities, and macroscopic and microscopic observations were c

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Elizondo-Luévano, Joel H., Rocío Castro-Ríos, Eduardo Sánchez-García, et al. "In Vitro Study of Antiamoebic Activity of Methanol Extracts ofArgemone mexicanaon Trophozoites ofEntamoeba histolyticaHM1-IMSS." Canadian Journal of Infectious Diseases and Medical Microbiology 2018 (July 30, 2018): 1–8. http://dx.doi.org/10.1155/2018/7453787.

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Abstract:

Infections caused by parasites in humans represent one of the main public health concerns. Amoebiasis, a parasitic infection caused byEntamoeba histolytica(E. histolytica), is considered endemic in Mexico, whereArgemone mexicana(A. mexicana) has been used in traditional medicine to treat intestinal parasitic diseases. The objective of this work was to evaluate the potential biological activity ofA. mexicanaonE. histolytica. For this purpose, a methanolic extract was prepared fromA. mexicanaleaves, and a differential fractionation was carried out with solvents of different polarities. The inhib

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