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Journal articles on the topic 'Antiamoebic'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

D., R. SHRIDHAR, V. REDDY SASTRY C., K. MARWAH A., PADMA PARIHAR (Miss), and B. LAL K. "Synthesis and Biological Activity of some New 2-(Heteroaryl)vinylsulphonyl Derivatives." Journal of Indian Chemical Society Vol. 62, Jul 1985 (1985): 537–40. https://doi.org/10.5281/zenodo.6321942.

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Chemistry Division, IDPL Research Centre, Indian Drugs and Pharmaceuticals Limited, Hyderabad-500 037 <em>Manuscript received 26 December 1984, accepted 31 July 1985</em> Several new 2-[(5 nitro-t-methyl-2-imldazolyl-, 5-nltro-2-furyl·, and 5-nitro-2- thienyl)vinyl)-<em>N</em>-arylsulpbonamides and sulphonyl heterocycles (1 and 2) have been prepared and screened for their \(in\) \(vitro\) antibacterial, antifungal, antiamoeblc, antitrlchomonal and \(in\) \(vivo\) anthelmintic activities, against a variety of microorganisms. Some of the compounds possess promising antibacterial

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2

Lê, Hương Giang, Tuấn Cường Võ, Jung-Mi Kang, et al. "Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species." Parasites, Hosts and Diseases 61, no. 4 (2023): 449–54. http://dx.doi.org/10.3347/phd.23078.

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Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the an

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3

Baig, Abdul M., and Naveed A. Khan. "Anesthesia With Antiamoebic Effects." Journal of Neurosurgical Anesthesiology 26, no. 4 (2014): 409–10. http://dx.doi.org/10.1097/ana.0000000000000036.

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4

Lakshmi, Vijai, and Sheela Ghosal. "Antiamoebic Activity of Marine Sponge Spongia officinalis var. ceylonensis Dendy." Bangladesh Pharmaceutical Journal 17, no. 1 (2015): 38–42. http://dx.doi.org/10.3329/bpj.v17i1.22312.

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Human amoebiasis due to infection by Entamoeba histolytica is mainly associated with morbidity thus affecting the quality of life and pace of developmental activities of countries with warm climatic conditions. A consistently high global incidence of this disease has been reported. In an endeavor to identify novel molecules with potent antiamoebic activity and lower side-effect, the present study was designed to investigate antiamoebic activity in Spongia officinalis extracts/fractions followed by isolation and characterization of bioactive molecules. The methanol extract of the S. officinalis

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5

Akbar, Noor, Mohammed I. El-Gamal, Balsam Qubais Saeed, et al. "Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii." Antibiotics 11, no. 9 (2022): 1183. http://dx.doi.org/10.3390/antibiotics11091183.

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We examined the antiamoebic effect of several imidazothiazole derivatives on Acanthamoeba castellanii of the T4 genotype. Trypan blue exclusion assays and haemocytometer counting were used to determine the reduction in A. castellanii trophozoite proliferation, in response to treatment with these compounds. To determine the effects of these compounds on host cells, lactate dehydrogenase assay was performed using HeLa cell lines. Amoebicidal assays revealed that the tested compounds at concentrations of 50 µM significantly inhibited amoebae trophozoites compared to controls. Compounds 1m and 1zb

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6

La Kilo, Akram, La Ode Aman, Ismail Sabihi, and Jafar La Kilo. "Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico." Indo. J. Chem. Res. 7, no. 1 (2019): 9–24. http://dx.doi.org/10.30598//ijcr.2019.7-akr.

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This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear

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7

La Kilo, Akram, La Ode Aman, Ismail Sabihi, and Jafar La Kilo. "Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico." Indonesian Journal of Chemical Research 7, no. 1 (2019): 9–24. http://dx.doi.org/10.30598/ijcr.2019.7-akr.

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This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear

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8

Sharma, Poonam, and Jayashri Devi Sharma. "A review of plant species assessedin?vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties." Phytotherapy Research 15, no. 1 (2001): 1–17. http://dx.doi.org/10.1002/1099-1573(200102)15:1<1::aid-ptr959>3.0.co;2-l.

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9

Wani, Mohmmad Younus, Abdul Roouf Bhat, Amir Azam, Fareeda Athar, and Abilio J. F. N. Sobral. "New transition metal complexes containing imidazole rings endowed with potential antiamoebic activity." MedChemComm 7, no. 5 (2016): 982–89. http://dx.doi.org/10.1039/c6md00013d.

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Imidazole-hydrazones were found to be better antiamoebic lead molecules compared to the standard drug metronidazole (MNZ). Chelation of these bioactive ligands with metals enhanced their activity profiles.

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10

Lakshmi, Vijai, and Sheela Ghosal. "In vitro and in vivo Antiamoebic Potential of Actinopyga lecanora (Jaeger)." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 118–20. http://dx.doi.org/10.3329/bpj.v18i2.24308.

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Human amoebiasis, due to Entamoeba histolytica infection, is mainly associated with morbidity thus affecting the quality of life and pace of development in the countries with warm climatic conditions. So far, the available drugs provide only symptomatic relief and they are not devoid of side effects. This leads to obtain novel molecules from natural sources having antiamoebic activity. The methanol extract of Actinopyga lecanora (Jaeger) displayed antiamoebic activity. It showed MIC 125 ?g/ml in our in-vitro studies, but when it was tested in rats, it revealed 88% inhibition of trophozoites at

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11

Manna, Dipak, Pradeep K. Dutta, Basudeb Achari, and Anuradha Lohia. "A Novel Galacto-Glycerolipid from Oxalis corniculata Kills Entamoeba histolytica and Giardia lamblia." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4825–32. http://dx.doi.org/10.1128/aac.00546-10.

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ABSTRACT Oxalis corniculata is a naturally occurring weed that has been used in traditional medicine for the cure of dysentery and diarrhea in India. One of the common causes of dysentery is due to infection by the protist pathogen Entamoeba histolytica. Bioactivity profiling of extracts from O. corniculata identified several compounds that showed antiamoebic activity in axenic cultures of E. histolytica. These were characterized by nuclear magnetic resonance, infrared, and mass spectrometry as (i) Oc-1, a mixture of saturated fatty acids C24 to C28; (ii) Oc-2, a mixture of long-chain alcohols

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12

KALYANAM, N., and S. G. MANJUNATHA. "ChemInform Abstract: Studies on Antiamoebic Compounds. Part 2. Antiamoebic Activity of Dichloroacetamides of 1,5-Benzodiazepinones and Tetrahydroquinoxalinones." ChemInform 23, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.199205122.

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13

Talbott, Maya, Vicky Cevallos, Michael C. Chen, et al. "Synergy Testing of Antiamoebic Agents for Acanthamoeba." Cornea 38, no. 10 (2019): 1309–13. http://dx.doi.org/10.1097/ico.0000000000002055.

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14

Calzada, Fernando, Mariana Meckes, and Roberto Cedillo-Rivera. "Antiamoebic and Antigiardial Activity of Plant Flavonoids**." Planta Medica 65, no. 01 (1999): 78–80. http://dx.doi.org/10.1055/s-2006-960445.

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15

Calzada, Fernando, Elizabeth Barbosa, and Roberto Cedillo-Rivera. "Antiamoebic activity of benzyl glucosinolate fromLepidium virginicum." Phytotherapy Research 17, no. 6 (2003): 618–19. http://dx.doi.org/10.1002/ptr.1210.

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16

Bhutani, K., G. Sharma, and Mohd Ali. "Plant Based Antiamoebic Drugs; Part I. Antiamoebic Activity of Phenanthroindolizidine Alkaloids; Common Structural Determinants of Activity with Emetine." Planta Medica 53, no. 06 (1987): 532–36. http://dx.doi.org/10.1055/s-2006-962803.

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17

Sangsuwon, Chanyapat, and Weena Jirujchariyakul. "Development of Microemulsion of Phytosteryl Glycoside in DMSO and Tween 20 for Increase Antiamoebic Activity." Key Engineering Materials 675-676 (January 2016): 27–30. http://dx.doi.org/10.4028/www.scientific.net/kem.675-676.27.

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Peperomia pellucida (Piperaceae) of Thai name “Phak kra sang” is medicinal plant. They are eaten in a salad or as cooked vegetable for protected glaucoma, eye inflammation. Recently, The methanol fraction of P. pellucida was tested for antiamoebic effect. Acanthamoeba spp. are protozoa, free-living in the environment and feed on bacteria. Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis. P. pellucida is medicinal plants, and was interesting for studied antiamobic. The separation by column chromatography (CC) used organic solvent of methanol and ethyl acetate (3:7) gave phyt

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18

López-Vallejo, Fabian, Rafael Castillo, Lilián Yépez-Mulia, and José L. Medina-Franco. "Benzotriazoles and Indazoles Are Scaffolds with Biological Activity against Entamoeba histolytica." Journal of Biomolecular Screening 16, no. 8 (2011): 862–68. http://dx.doi.org/10.1177/1087057111414902.

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Parasitic infections caused by Entamoeba histolytica are still major threats against public health, especially in developing countries. Although current therapies exist, the problems associated with parasite resistance and negative side effects make it imperative to search for new therapeutic agents. A systematic scaffold analysis reported herein of a public database containing 474 antiamoebic compounds reveals that benzimidazole is the most active scaffold reported thus far. To gain insights into the antiamoebic activity of novel compounds, the authors report herein the biological activity of

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19

Hayat, Faisal, Amir Azam, and Dongyun Shin. "Recent progress on the discovery of antiamoebic agents." Bioorganic & Medicinal Chemistry Letters 26, no. 21 (2016): 5149–59. http://dx.doi.org/10.1016/j.bmcl.2016.09.040.

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20

Cimanga, Kanyanga, Kabangu Kambu, Lutete Tona, et al. "Antiamoebic Activity of Iridoids from Morinda morindoides Leaves." Planta Medica 72, no. 8 (2006): 751–53. http://dx.doi.org/10.1055/s-2006-931581.

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21

Abid, Mohammad, Subhash M. Agarwal, and Amir Azam. "Synthesis and antiamoebic activity of metronidazole thiosemicarbazone analogues." European Journal of Medicinal Chemistry 43, no. 9 (2008): 2035–39. http://dx.doi.org/10.1016/j.ejmech.2007.12.007.

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22

Zaman, Viqar, Syed Munazza Manzoor, Mehreen Zaki, Nauman Aziz, and Anwar-ul-Hassan Gilani. "The presence of antiamoebic constituents in Psyllium husk." Phytotherapy Research 16, no. 1 (2002): 78–79. http://dx.doi.org/10.1002/ptr.886.

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23

Gan, Tong, and James M. Cook. "Partial synthesis of the antiamoebic bisindole alkaloid (−)-macrocarpamine." Tetrahedron Letters 37, no. 29 (1996): 5037–38. http://dx.doi.org/10.1016/0040-4039(96)01010-6.

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24

Sangsuwon, Chanyapat, Weena Jirujchariyakul, and Kosol Roongruangchai. "Chemical Constituents and Antiamoebic of Methanolic Fraction from Peperomia pellucida (Linn.)Kunth." Applied Mechanics and Materials 709 (December 2014): 417–21. http://dx.doi.org/10.4028/www.scientific.net/amm.709.417.

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Acanthamoeba spp. is the free living protozoain the environment which are opportunistic pathogens of human [1]. Acanthamoeba spp. is the causative agents of Acanthamoeba keratitis (AK)[2]. The risks of AK increased by using contact lens are not good hygiene. Antiamoebic therapy were biguanides chlorhexidine (BCH) or polyhexamethylene biguanide (PHMB) which were not effective enough to kill Acanthamoeba cysts [3]. Reported, plant for protected glaucoma, anti-inflammatory and analgesic properties are Peperomiapellucida in Piperaceae family. This interesting of studied P. pellucida for antiamoebi

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25

Singh, Shailendra, Neelam Bharti, Manoj Chugh, Fehmida Naqvi, and Amir Azam. "Activity of Extracts and Procesterol from Calotropis gigantea against Entamoeba histolytica." Natural Product Communications 5, no. 6 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500608.

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Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.

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26

Maliński, Michał P., Jaromir Budzianowski, Małgorzata Kikowska, et al. "Two Ecdysteroids Isolated from Micropropagated Lychnis flos-cuculi and the Biological Activity of Plant Material." Molecules 26, no. 4 (2021): 904. http://dx.doi.org/10.3390/molecules26040904.

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Genetically uniform plant material, derived from Lychnis flos-cuculi propagated in vitro, was used for the isolation of 20-hydroxyecdysone and polypodine B and subjected to an evaluation of the antifungal and antiamoebic activity. The activity of 80% aqueous methanolic extracts, their fractions, and isolated ecdysteroids were studied against pathogenic Acanthamoeba castellani. Additionally, a Microtox® acute toxicity assay was performed. It was found that an 80% methanolic fraction of root extract exerts the most potent amoebicidal activity at IC50 of 0.06 mg/mL at the 3rd day of treatment. Bo

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27

Quintanilla-Licea, Ramiro, Javier Vargas-Villarreal, María Julia Verde-Star, Verónica Mayela Rivas-Galindo, and Ángel David Torres-Hernández. "Antiprotozoal Activity Against Entamoeba histolytica of Flavonoids Isolated from Lippia graveolens Kunth." Molecules 25, no. 11 (2020): 2464. http://dx.doi.org/10.3390/molecules25112464.

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Amebiasis caused by Entamoeba histolytica is nowadays a serious public health problem worldwide, especially in developing countries. Annually, up to 100,000 deaths occur across the world. Due to the resistance that pathogenic protozoa exhibit against commercial antiprotozoal drugs, a growing emphasis has been placed on plants used in traditional medicine to discover new antiparasitics. Previously, we reported the in vitro antiamoebic activity of a methanolic extract of Lippia graveolens Kunth (Mexican oregano). In this study, we outline the isolation and structure elucidation of antiamoebic co

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28

Mukhtar, Sayeed, Waleed Atef Manasreh, Humaira Parveen, and Amir Azam. "Synthesis, Characterization, Antiamoebic Activity and Toxicity of Ferrocenyl Chalcones." Asian Journal of Chemistry 26, no. 24 (2014): 8407–12. http://dx.doi.org/10.14233/ajchem.2014.17697.

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29

Padilla, Nicol??s, Jose de I??iguez, Alfonso Alarcon, and Roberto Barreda. "Antiamoebic Chemoprophylaxis with Quinfamide in Mexican Adolescents and Adults." Clinical Drug Investigation 22, no. 6 (2002): 377–83. http://dx.doi.org/10.2165/00044011-200222060-00005.

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30

Tona, L., K. Kambu, N. Ngimbi, K. Cimanga, and A. J. Vlietinck. "Antiamoebic and phytochemical screening of some Congolese medicinal plants." Journal of Ethnopharmacology 61, no. 1 (1998): 57–65. http://dx.doi.org/10.1016/s0378-8741(98)00015-4.

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31

Gonzalez-Garza, Maria Teresa, and Salvador Said-Fernandez. "Entamoeba histolytica: Potent in vitro antiamoebic effect of gossypol." Experimental Parasitology 66, no. 2 (1988): 253–55. http://dx.doi.org/10.1016/0014-4894(88)90097-5.

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32

Siddiqui, Ruqaiyyah, Shareni Jeyamogan, Salwa Mansoor Ali, Fatima Abbas, K. A. Sagathevan, and Naveed Ahmed Khan. "Crocodiles and alligators: Antiamoebic and antitumor compounds of crocodiles." Experimental Parasitology 183 (December 2017): 194–200. http://dx.doi.org/10.1016/j.exppara.2017.09.008.

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33

Padilla, Nicolas, Rosalinda Diaz, Alfonso Alarcon, and Roberto Barreda. "Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study." Scientific World JOURNAL 2 (2002): 1070–78. http://dx.doi.org/10.1100/tsw.2002.174.

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This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency ofEntamoeba histolyticacysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence ofE. histolyticacysts after a parasitoscopic analysis

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34

Varghese, Sneha Susan, and Sudip Kumar Ghosh. "Stress‐responsive Entamoeba topoisomerase II: a potential antiamoebic target." FEBS Letters 594, no. 6 (2020): 1005–20. http://dx.doi.org/10.1002/1873-3468.13677.

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35

PARTHASARATHY, P. C., L. ANANTHAN, M. A. LIKHATE, S. G. MANJUNATHA, and N. KALYANAM. "ChemInform Abstract: Antiamoebic Compounds. Part 5. Synthesis of Dichloromethanesulfonamides." ChemInform 24, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199336129.

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36

Parveen, Humaira, Sayeed Mukhtar, and Amir Azam. "Novel Ferrocenyl Linked Pyrazoline Analogs as Potent Antiamoebic Agents." Journal of Heterocyclic Chemistry 53, no. 2 (2015): 473–78. http://dx.doi.org/10.1002/jhet.2427.

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37

González-Fernández, Sara, Victor Lozano-Iturbe, Mª Fe Menéndez, et al. "A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP." Antibiotics 11, no. 8 (2022): 1054. http://dx.doi.org/10.3390/antibiotics11081054.

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Silver nanoparticles (AgNPs) play an important role in the medical field due to their potent antimicrobial activity. This, together with the constant emergence of resistance to antimicrobial drugs, means AgNPs are often investigated as an alternative to solve this problem. In this article, we analyzed the antifungal and antiamoebic effects of a recently described type of AgNP, silver nanorings (AgNRs), and compared them with other types of AgNPs. Tests of the activity of AgNPs against various fungal and amoebic species were carried out. In all cases, AgNPs showed a high biocidal effect, althou

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38

Rodrigues, Barbara Czerniak, Maria Luiza Carneiro Büchele, Carolina de Jesus de Camargo, Fabíola Branco Filippin-Monteiro, and Karin Silva Caumo. "In Vitro Stability of the Biological Activity of Voriconazole against Acanthamoeba castellanii." Parasitologia 3, no. 2 (2023): 194–204. http://dx.doi.org/10.3390/parasitologia3020020.

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Acanthamoeba keratitis (AK) is a rare cornea disease caused by species of the Acanthamoeba genus. The antifungal voriconazole blocks the ergosterol synthesis in the protozoan membrane and is active against the cysts and trophozoites of Acanthamoeba spp. Due to the low stability of voriconazole, its options for eye drops are scarce. This study aimed to investigate the stability of the biological activity of voriconazole against two strains of Acanthamoeba castellanii and one clinical isolate from a patient with AK. To evaluate the stability of the biological activity of voriconazole, strains of

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Siddiqui, Ruqaiyyah, Anania Boghossian, Bushra Khatoon, et al. "Antiamoebic Properties of Metabolites against Naegleria fowleri and Balamuthia mandrillaris." Antibiotics 11, no. 5 (2022): 539. http://dx.doi.org/10.3390/antibiotics11050539.

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Naegleria fowleri and Balamuthia mandrillaris are free-living, opportunistic protists, distributed widely in the environment. They are responsible for primary amoebic meningoencephalitis (PAM) and granulomatous amoebic encephalitis (GAE), the fatal central nervous infections with mortality rates exceeding 90%. With the rise of global warming and water shortages resulting in water storage in tanks (where these amoebae may reside), the risk of infection is increasing. Currently, as a result of a lack of awareness, many cases may be misdiagnosed. Furthermore, the high mortality rate indicates the

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40

Rassu, Giovanna, Elisabetta Gavini, Antonella Mattana, and Paolo Giunchedi. "Improvement of Antiamoebic Activity of Rokitamycin Loaded in Chitosan Microspheres." Open Drug Delivery Journal 2, no. 1 (2008): 38–43. http://dx.doi.org/10.2174/1874126600802010038.

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41

Cartuche, Luis, María Reyes-Batlle, Ines Sifaoui, et al. "Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures." Marine Drugs 17, no. 10 (2019): 588. http://dx.doi.org/10.3390/md17100588.

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Indolocarbazoles are a family of natural alkaloids characterized by their potent protein kinase and topoisomerase I inhibitory activity. Among them, staurosporine (1) has exhibited promising inhibitory activity against parasites. Based on new insights on the activity and mechanism of action of STS in Acanthamoeba parasites, this work reports the isolation, identification, and the anti-Acanthamoeba activity of the minor metabolites 7-oxostaurosporine (2), 4′-demethylamino-4′-oxostaurosporine (3), and streptocarbazole B (4), isolated from cultures of the mangrove strain Streptomyces sanyensis. A

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42

Partridge, S. J., P. F. Russell, M. M. Anderson, et al. "IN-VITRO CYTOTOXIC, ANTIMALARIAL AND ANTIAMOEBIC ACTIVITIES OF PROTOBERBERINE ALKALOIDS." Journal of Pharmacy and Pharmacology 42, S1 (1990): 97P. http://dx.doi.org/10.1111/j.2042-7158.1990.tb14470.x.

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43

Singh, Shailendra, Neelam Bharti, and Prabhu P. Mohapatra. "Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents†." Chemical Reviews 109, no. 5 (2009): 1900–1947. http://dx.doi.org/10.1021/cr068217k.

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44

Ansari, Mohammad Fawad, Shadab Miyan Siddiqui, Subhash M. Agarwal, Kunwar Somesh Vikramdeo, Neelima Mondal, and Amir Azam. "Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies." Bioorganic & Medicinal Chemistry Letters 25, no. 17 (2015): 3545–49. http://dx.doi.org/10.1016/j.bmcl.2015.06.091.

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45

Ansari, Mohammad Fawad, Afreen Inam, Kamal Ahmad, Shehnaz Fatima, Subhash M. Agarwal, and Amir Azam. "Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents." Bioorganic & Medicinal Chemistry Letters 30, no. 23 (2020): 127549. http://dx.doi.org/10.1016/j.bmcl.2020.127549.

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46

Moon, Eun-Kyung, So-Hee Kim, Yeonchul Hong, Dong-Il Chung, Youn-Kyoung Goo, and Hyun-Hee Kong. "Autophagy Inhibitors as a Potential Antiamoebic Treatment for Acanthamoeba Keratitis." Antimicrobial Agents and Chemotherapy 59, no. 7 (2015): 4020–25. http://dx.doi.org/10.1128/aac.05165-14.

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ABSTRACTAcanthamoebacysts are resistant to extreme physical and chemical conditions. Autophagy is an essential pathway for encystation ofAcanthamoebacells. To evaluate the possibility of an autophagicAcanthamoebaencystation mechanism, we evaluated autophagy inhibitors, such as 3-methyladenine (3MA), LY294002, wortmannin, bafilomycin A, and chloroquine. Among these autophagy inhibitors, the use of 3MA and chloroquine showed a significant reduction in the encystation ratio inAcanthamoebacells. Wortmannin also inhibited the formation of mature cysts, while LY294002 and bafilomycin A did not affec

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Makhlouf, Zinb, Noor Akbar, Naveed Ahmed Khan, et al. "Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone." Antibiotics 11, no. 12 (2022): 1721. http://dx.doi.org/10.3390/antibiotics11121721.

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Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent. Accordingly, there is a pressing need for novel compounds. Nanotechnology has been gaining attention for enhancing drug delivery and reducing toxicity. Previous work has shown that various antibiotic classes displayed antiamoebic activity. Herein, we employed two antibiotics: ampicillin and ceftriaxone, conjugated with the nanocarrier zinc oxide and β-cyclodextrin, and tested them against A. castellanii via am

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Hayat, Faisal, Hussain Mustatab Wahedi, Seonghyeok Park, Saba Tariq, Amir Azam, and Dongyun Shin. "Novel aryl carbamate derivatives of metronidazole as potential antiamoebic agents." Archives of Pharmacal Research 39, no. 1 (2015): 33–42. http://dx.doi.org/10.1007/s12272-015-0686-4.

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Chatterjee, D. K., N. Iyer, and B. N. Ganguli. "Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models." Parasitology Research 74, no. 1 (1987): 30–33. http://dx.doi.org/10.1007/bf00534928.

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Ansari, Mohammad Fawad, Shadab Miyan Siddiqui, Kamal Ahmad, et al. "Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids." European Journal of Medicinal Chemistry 124 (November 2016): 393–406. http://dx.doi.org/10.1016/j.ejmech.2016.08.053.

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