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Relevant bibliographies by topics / Antiangiogenic therapy / Dissertations / Theses

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Dissertations / Theses on the topic 'Antiangiogenic therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Bullous, Aaron. "Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy." Thesis, University of Hull, 2010. http://hydra.hull.ac.uk/resources/hull:4695.

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Photodynamic therapy is a novel cancer treatment, involving the combination of light, photosensitiser and molecular oxygen to produce cytotoxic species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit a passive selectively towards cancerous tissue. Therapeutically, this results in a variety of unfavourable characteristics, obstructing PDT from becoming a more viable cancer treatment. Research has been directed towards improving the pharmacokinetic and biodistribution profiles of photosensitisers, which can be achieved by conjugating the photosen

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2

Ferreira, Daniela Pais. "Synergy between antiangiogenic and immuno-therapies in breast cancer." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14940.

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Mestrado em Biomedicina Molecular<br>Angiogenesis is crucial for breast cancer growth, progression and dissemination, making it a promising therapeutic target. Given the dominant role of Vascular Endothelial Growth Factor (VEGF) signaling in tumor angiogenesis, the majority of clinical studies with anti-angiogenic therapies in breast cancer were based on VEGF blockade. However, lack of clinical efficacy was observed in all clinical studies with antiangiogenic therapies for breast cancer. Since angiopoietin 2 (ANG-2) has been reported to induce therapeutic resistance after VEGF-targeted therapi

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Marquez, Tatiana Vieira de Brito. "Estudo comparativo entre o Bevacizumabe intravitreo e a fotocoagulação a laser com oftalmoscopio binocular indireto na retinopatia da prematuridade." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tede/4189.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-02-20T15:09:52Z No. of bitstreams: 2 Dissertação - Tatiana Vieira de Brito Marquez - 2010.pdf: 2722177 bytes, checksum: d3f571bcc9c3e44cf51b9d4539e6191d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-02-20T15:10:12Z (GMT) No. of bitstreams: 2 Dissertação - Tatiana Vieira de Brito Marquez - 2010.pdf: 2722177 bytes, checksum: d3f571bcc9c3e44cf51b9d4539e6191d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114

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4

Nicolò, Chiara. "Mathematical modelling of neoadjuvant antiangiogenic therapy and prediction of post-surgical metastatic relapse in breast cancer patients." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0183.

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Pour les patients diagnostiqués avec un cancer au stade précoce, les décisions de traitement dépendent de l’évaluation du risque de rechute métastatique. Les outils de pronostic actuels sont fondés sur des approches purement statistiques, sans intégrer les connaissances disponibles sur les processus biologiques à l’oeuvre. L’objectif de cette thèse est de développer des modèles prédictifs du processus métastatique en utilisant une approche de modélisation mécaniste et la modélisation à effets mixtes. Dans la première partie, nous étendons un modèle mathématique du processus métastatique pour d

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5

Knezevic, Zoran [Verfasser]. "Apelinergic system and its role in the development of resistance to antiangiogenic therapy in cancer treatment / Zoran Knezevic." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1222163365/34.

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6

Maietta, Antonio. "Assessing the efficiency of In Vivo electroporation as a nonviral gene transfer technique and studying its application in antiangiogenic cancer gene therapy and cancer immunotherapy." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31267.

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Electroporation refers to a technique that makes use of electrical pulses to create transient and reversible pores into cellular membranes which allows the passage of drugs and macromolecules, such as plasmid DNA, into the cell's interior. It is a widely used laboratory procedure for the transfection of cultured mammalian cells, plant cells and bacteria. Only recently has in vivo electroporation been used for the transfer of genetic material into living tissue, such as muscle, hepatocytes, and tumors of experimental animals. Using a luciferase assay, we have shown that electroporation-mediated

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7

Horsley, Laura. "Imaging biomarkers of the tumour microenvironment to assess early response in patients treated with anti-angiogenic therapy." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/imaging-biomarkers-of-the-tumour-microenvironment-to-assess-early-response-in-patients-treated-with-antiangiogenic-therapy(b051dfc5-d3ec-44a7-8fb6-a641626f0f89).html.

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Background: Angiogenesis is the process by which new blood vessels develop from existing vasculature and is a critical step in all tumours to facilitate growth beyond a few millimetres. As this process is largely inactive in physiological circumstances in adults, it represents an attractive therapeutic target in oncology. Drugs that target the angiogenic process are classified as anti-angiogenic agents. The first anti-angiogenic drug to be approved by the FDA was bevacizumab; a recombinant humanized monoclonal antibody against VEGF. Randomised studies in colorectal cancer (and other solid mali

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8

Brünner, Jeanette [Verfasser]. "Antiangiogene Therapie in Kombination mit Temozolomid beim experimentellen MGMT-methylierten Glioblastom / Jeanette Brünner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940363/34.

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9

Uhl, Christian [Verfasser]. "Die Rolle des ephrinB2-EphB4 Signalweges bei der Vermittlung vaskulärer Resistenzmechanismen unter antiangiogener Therapie / Christian Uhl." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1195528647/34.

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10

Markel, Moritz [Verfasser]. "Der Einfluss von EphB4 auf die Vermittlung vaskulärer Resistenz im Rahmen einer antiangiogenen Therapie / Moritz Markel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1114137618/34.

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11

Brucker, David. "Intravitalmikroskopische Studien im Mausmodell mit kraniellen Fenstern: Fluoreszenzdarstellungen bei der Diagnostik und antiangiogenen Therapie von Gehirntumoren." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-172861.

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12

Kurniawan, Niehls [Verfasser], and Nils [Akademischer Betreuer] Hansen-Algenstaedt. "Auswirkung von antiangiogener und antiproliferativer Therapie am murinen Modell des ossär metastasierten Mammakarzinoms nach Primariusresektion / Niehls Kurniawan. Betreuer: Nils Hansen-Algenstaedt." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/1020418303/34.

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13

Brucker, David [Verfasser], and Elisabeth [Akademischer Betreuer] Weiss. "Intravitalmikroskopische Studien im Mausmodell mit kraniellen Fenstern: Fluoreszenzdarstellungen bei der Diagnostik und antiangiogenen Therapie von Gehirntumoren / David Brucker. Betreuer: Elisabeth Weiss." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1056876611/34.

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14

Beier, Marie [Verfasser]. "Bedeutung von NDRG1 für die Angiogenese, Tumorproliferation und Therapieresistenz gegenüber einer antiangiogenen und antitumoralen Therapie im Rahmen eines experimentellen Gliommodells / Marie Beier." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234984407/34.

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15

戴國峰. "Gene therapy orthotopic hepatocellular carcinoma in rats using immunotherapy and antiangiogenic therapy strategies." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/77515704315666765084.

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16

Lopes, Rafaela Gonçalves. "Clinical biomarkers of response to antiangiogenic therapy with bevacizumab in glioblastoma." Dissertação, 2019. https://hdl.handle.net/10216/119832.

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17

Lopes, Rafaela Gonçalves. "Clinical biomarkers of response to antiangiogenic therapy with bevacizumab in glioblastoma." Master's thesis, 2019. https://hdl.handle.net/10216/119832.

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18

Enling, Chang, and 張恩菱. "Antiangiogenic-Targeting Microbubbles Combined with Ultrasound-Mediated Gene Therapy in Brain Tumors." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/03506802267218051955.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>103<br>Glioblastoma multiforme (GBM) is a malignant brain tumor with poor prognosis and high recurrence rate despite traditional chemotherapy. Ultrasound-targeted microbubbles destruction (UTMD) has been approved to achieve local blood-brain barrier disruption (BBBD), enhancing therapeutic agents into the brain. Besides, UTMD has been employed to deliver tumor-killing gene for cancer therapy. Tumor vessels in GBM are highly rich in VEGF-A, which could bind VEGFR2 on endothelial cells, is widely used in targeted therapy. In this study, we fabricated DNA-loaded cati

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19

"Antiangiogenic agents from tripterygium wilfordii for cancer treatment." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074749.

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Five traditional Chinese medicines were screened for their antiangiogenic activities through zebrafish angiogenic assay. Two of them, Tripterygium wilfordii and Rheum palmatum showed potential in the primary screening. T. wilfordii was selected in further study.<br>In the further investigation of antiangiogenic activity of triptolide on mammal systems, triptolide showed potent activity in human umbilical vein endothelial cells (HUVECs) assays including proliferation, migration and tube formation assay. It inhibited HUVEC proliferation with IC50 as low as 34 nM. It also showed more potency in H

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20

Tsai, Kun-Che, and 蔡坤哲. "In-vivo ultrasound-mediated antiangiogenic gene transfer on muscle for distal cancer therapy." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/70664788111074728613.

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博士<br>國立臺灣大學<br>醫學工程學研究所<br>98<br>Antiangiogenic gene therapy is a promising approach to inhibit neovascularization via angiogenesis, the growth of new blood vessels from preexisting ones. In recent years, hepatocellular carcinoma (HCC) is considered as one of the suitable targets for anti-angiogenic approaches due to its highly neovascularization. At the same time, ultrasound is believed to be a novel and effective tool to locally deliver gene into target tumors. The objective of this research work is to develop ultrasound-mediated gene transfer strategies to suppress the growth of the inocul

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21

Phipps, Colin. "Combination of Chemotherapy and Antiangiogenic Therapies: A Mathematical Modelling Approach." Thesis, 2009. http://hdl.handle.net/10012/4698.

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A brief introduction to cancer biology and treatment is presented with a focus on current clinical advances in the delivery of chemotherapy and antiangiogenic therapies. Mathematical oncology is then surveyed with summaries of various models of tumor growth, tumor angiogenesis and other relevant biological entities such as angiogenic growth factors. Both strictly time-dependent ordinary differential equation (ODE)-based and spatial partial differential equation (PDE)-based models are considered. These biological models are first developed into an ODE model where various treatment options can b

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22

Chan, Suit-Fong, and 陳雪芳. "Antiangiogenic Gene Therapy on Orthotopic Hepatocellular Carcinoma Using Combination of Endostatin and Pigment Epithelium-Derived Factor." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/37018714712144368622.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>95<br>The hepatocellular carcinoma is considered as one of the suitable targets for anti-angiogenic approaches due to its highly neovascularization. However, anti-angiogenic therapies aimed at single target can be neutralized by up-regulation of other pro-angiogenic factor. The fact that redundant angiogenic factor can be up-regulated by tumors in advanced stage of carcinoma suggests that the angiostatic strategies may require a combination of multiple anti-angiogenic factor. In this study, we assessed the therapeutic effects of combination therapy with two anti-ang

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23

Chan, Suit-Fong. "Antiangiogenic Gene Therapy on Orthotopic Hepatocellular Carcinoma Using Combination of Endostatin and Pigment Epithelium-Derived Factor." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0507200715110300.

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24

Liao, Ai-chi, and 廖艾琪. "Cloning of the genes of angiostatin and endostatin : Application of the antiangiogenic factors in cancer gene therapy." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/49249526005492462043.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>87<br>Based on the observation that solid tumor growth and metastasis are angiogenesis dependent, antiangiogenic tumor therapies have recently attracted intense interest for their broad-spectrum action, low toxicity, and, in the case of direct endothelial target, an absence of drug resistance. To promote tumor regression and to maintain dormancy, anti-angiogenic agents need to be chronically administered. Gene therapy offers a potential way to achieve sustained therapeutic release of potent antiangiogenic substances. Angiostatin and endostatin , the proteolytic fragm

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25

Huang, Kai-Wen, and 黃凱文. "Transarterial Antiangiogenetic Gene Therapy of Hepatocellular Carcinoma during Ischemia Challenge: A Rat Model with Intrahepatic Arterial Catheterization." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/37839070264989212091.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>91<br>Introduction Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, especial in the Asia. The only curative treatment is surgery. In fact, only 15-30% of patients with HCC is suitable for surgical management, so the outcome of HCC is always dismal. Most patients received the treatment of transcatheter arterial embolization(TAE), to disrupt the blood supply of tumor and make tumor necrosis. Unfortunately, TAE seemed to be a palliative method for treatment of HCC, most tumors received TAE were recurrent. It is necessary to find

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26

Juan, Ting-Yi, and 阮婷儀. "Overcoming the Resistance of Antiangiogenetic Therapy Resulted from Tumor Microenvironment Alteration by the Synergy with Glucuronide Prodrug: Co-treatment in a Cancer Xenograft Mouse Model." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/42378697265445066553.

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博士<br>國防醫學院<br>生命科學研究所<br>98<br>Renal cell carcinoma (RCC) accounts for 3% of all adult malignancies and clear cell RCC (ccRCC) is major type in renal cancer. The recent estimates of the cancer incidence worldwide about 208,000 new cases of kidney cancer have been diagnosed (1.9% of the world total), and 102,000 persons died because of kidney cancer in 2002. In Taiwan, there are 522 persons died because of kidney cancer in 2007, which is the 14th most common cause of cancer death in men and the 13th in women. Incidence and mortality rates are approximately 1.5 fold as high for men as for women

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