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Dissertations / Theses on the topic 'Antiarrhythmic effect'

Author: Grafiati

Published: 29 June 2021

Last updated: 29 July 2025

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1

Das, Kumuda C. "Amelioration of oxidative lung injury by antiarrhythmic agents." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39844.

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2

Crockett, Thomas Robert. "The mechanism(s) underlying the antiarrhythmic effect of drugs acting on endothelin receptors in myocardial ischaemia and reperfusion." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248261.

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3

El-Eraky, Hala Mohammed Tawfik. "The effect of gender on the pharmacokinetic and pharmacodynamic properties of drugs affecting cardiac repolarization : a study of antiarrhythmic drugs." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394683.

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4

Sylwan, Gustafsson Magdalena. "Den antiarytmiska effekten av magnesium : En litteraturstudie relaterat till magnesiumform, dos och typ av arytmi." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-105440.

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Bakgrund: Arytmi innebär en avvikande rytm hos hjärtat, alltså att det uppstått en avvikelse i impulsbildning och/eller impulsfortledning. Det kan inverka negativt på livskvalitén, orsaka följdsjukdomar eller leda till livshotande tillstånd. Utöver den konventionella behandlingen finns det behov av ytterligare alternativ. Magnesium är ett essentiellt mineralämne som är viktigt för hjärtats elektrofysiologi. Det har i tidigare studier visat sig att magnesium har haft effekt på postoperativt uppkomna arytmier och att låga nivåer av magnesium hos en frisk population har ökat risken för utveckland

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5

Spiers, James Paul. "The cardiovascular effects of a novel antiarrhythmic drug (UK-52,046)." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356976.

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6

Sun, Wei. "Antiarrhythmic effects of ischaemic preconditioning in anaesthetised rats : studies on the roles of bradykinin and nitric oxide." Thesis, University of Strathclyde, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249783.

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7

Yong, Sandro Luis. "A series of amino-2-cyclohexyl esters, their electrophysiological and antiarrhythmic effects as related to actions on ischemia-induced arrhythmias." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/NQ56650.pdf.

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8

Bugana, Marco. "Mathematical Modeling to Investigate Antiarrhythmic Drug Side Effects: Rate-Dependence Role in Ionic Currents and Action Potentials Shape in the O’Hara Model." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3529/.

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Sudden cardiac death due to ventricular arrhythmia is one of the leading causes of mortality in the world. In the last decades, it has proven that anti-arrhythmic drugs, which prolong the refractory period by means of prolongation of the cardiac action potential duration (APD), play a good role in preventing of relevant human arrhythmias. However, it has long been observed that the “class III antiarrhythmic effect” diminish at faster heart rates and that this phenomenon represent a big weakness, since it is the precise situation when arrhythmias are most prone to occur. It is well known that

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9

Hung, Chi-Feng, and 洪啟峰. "Electromechanical effect of two antiarrhythmic agents, JKL 1067 and N-allylsecoboldine, on cardiac tissue." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/51832110654720344978.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>82<br>JKL 1067 和 N-Allylsecoboldine(STL-1)是兩個合成生物鹼，發現具有增強收縮力及減慢心跳頻率之作用。論文主要研究它們在心臟組織之電生理及增強心收縮力之效果，並且評估它們的抗心律不整的活性。在大白鼠心房及心室肌組織，1 到 30 uM JKL 1067 會使收縮力隨濃度增加而增強，然而，其心房自發性跳動頻率則被減慢。在大白鼠、天竺鼠的實驗中，會使因冠狀動脈結紮再灌流及ouabain所誘發之心律不整恢復為正常心律。之效果，不會因前處理腎腺素阻斷劑而發生改變，但是會被前處理的鉀管道阻斷劑所減弱。在大白鼠心室細胞中，動作電位期間會隨 JKL 1067 濃度的增加而延長，且減慢伴隨動作電位去極化速率。JKL 1067可減少鈉電流，並且使鈉電流穩定狀態不活化曲線向負電位方向漂移。其恢復之時間常數也受影響而延長。對於瞬時外流鉀電流，可使其尖峰電流

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10

Wu, Adonis Zhi-Yang, and 吳智陽. "Underlying Ionic Channel Mechanism of Antiarrhythmic Effect by a Green Tea Polyphenol, (-)-Epicatechin-3-gallate." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/17957081558289252085.

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博士<br>國防醫學院<br>生命科學研究所<br>101<br>The voltage-gated sodium currents (INa) contribute to cardiac spontaneous action potential (sAP) upstroke, influence AP duration (APD), and may be responsible for early afterdepolarization (EAD). (-)-Epicatechin-3-gallate (ECG), a polyphenol extracted from green tea, has been proposed as an effective compound for improving cardiac contractility. However, the therapeutic potential of ECG on arrhythmia remains unknown. I furnished a definition for the temporal involvement of INa on the characterized ontogenic sAP in primary culture of neonatal rat ventricular myo

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11

Leifert, Wayne R. "Antiarrhythmic mechanisms of omega-3 polyunsaturated fatty acids in rat ventricular cardiomyocytes / Wayne R. Leifert." Thesis, 2001. http://hdl.handle.net/2440/19856.

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Includes bibliographical references (leaves 237-257).<br>xx, 257 leaves : ill. ; 30 cm.<br>Investigates the mechanisms underlying the antiarrhythmic effects of omega-3 polyunsaturated fatty acids using adult rat ventricular cardiac myocytes.<br>Thesis (Ph.D.)--Adelaide University, Dept. of Physiology, 2001

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12

Leifert, Wayne R. "Antiarrhythmic mechanisms of omega-3 polyunsaturated fatty acids in rat ventricular cardiomyocytes / Wayne R. Leifert." 2001. http://hdl.handle.net/2440/19856.

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Includes bibliographical references (leaves 237-257).<br>xx, 257 leaves : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Investigates the mechanisms underlying the antiarrhythmic effects of omega-3 polyunsaturated fatty acids using adult rat ventricular cardiac myocytes.<br>Thesis (Ph.D.)--Adelaide University, Dept. of Physiology, 2001

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13

Ying, Shin-Rern, and 英士仁. "Antiarrhythmic Effects of d,l-Sotalol on Rat Cardiac Tissue." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/92523133904027173842.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>85<br>Abstracts 1. Sotalol (d,l-sotalol, MJ 1999) 4(-[1-hydroxy-2-isopropyl- amino)ethyl] methanesulfonanilide, a methanesulfonanilide derivative, is a unique class III antiarrhythmic agent with β-adrenoceptor blocking activity. In vitro and in vivo studies of animal models and clinical trials in human have shown that sotalol has better benefits than those of conventional drugs. But its low potency in antiarrhythmic activity and adve

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14

Ander, Bradley P. "Antiarrhythmic and electrophysiologic effects of alpha-linolenic acid from dietary flaxseed." 2007. http://hdl.handle.net/1993/20447.

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15

Ninio, Daniel Marc. "An examination of the role of atrial stretch in the genesis of atrial fibrillation and the antiarrhythmic effects of dietary fish oil." Thesis, 2009. http://hdl.handle.net/2440/62457.

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This thesis is submitted as a PhD by portfolio of publications. It explores the role of atrial stretch in the pathogenesis of atrial fibrillation and the modulating effect of dietary fish oil. Atrial fibrillation is more common in conditions associated with atrial stretch. This relationship is thought to be due to changes in activity of stretch-sensitive ion channels and alterations in calcium handling. Increasing atrial pressure in isolated rabbit hearts shortens atrial refractoriness and enhances the inducibility and sustainability of atrial fibrillation. The first of the publications in

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16

Middelberg, Claudius [Verfasser]. "Die Bedeutung der Hüllschichten der Xenopus-Oozyte für den Effekt der Antiarrhythmika Propafenon, Flecainid und Verapamil auf den klonierten Kaliumkanal Kv2.1 / vorgelegt von Claudius Middelberg." 2004. http://d-nb.info/971045321/34.

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