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Dissertations / Theses on the topic 'Antibacterial agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Zhang, Huichun. "Metal oxide-facilitated oxidation of antibacterial agents." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-07072004-152317/unrestricted/zhang%5Fhuichun%5F200407%5Fphd.pdf.

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Thesis (Ph. D.)--School of Civil and Environmental Engineering, Georgia Institute of Technology, 2005. Directed by Ching-Hua Huang.<br>Wine, Paul, Committee Member ; Pavlostathis, Spyros, Committee Member ; Mulholland, James, Committee Member ; Yiacoumi, Sotira, Committee Member ; Huang, Ching-Hua, Committee Chair. Includes bibliographical references.

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2

Tan, Jinlong. "Design and Synthesis of Novel Antibacterial Agents." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25809.

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The latest data on antimicrobial resistance (AMR) related mortality is alarming. A conservative estimate places current global death due to AMR infections at 700,000 annually and projections anticipate that this could rise to 10 million by 2050. Over 50 major initiatives have emerged from the European Union (EU), United Kingdom (UK) and the United States of America (US) since 2007 aimed at improving surveillance, stewardship, and refreshing the drug development pipeline. The identification of priority pathogens, such as the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumo

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3

Marshall, Neil J. "Antibacterial agents designed to exploit peptide transport systems." Thesis, Bangor University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262012.

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4

Penishkevich, Ya. "Ophthalmic topical antibacterial agents: current and evolving options." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18146.

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5

Smith, Nichola Ann. "Photoactivatable Ru(II) polypyridyl complexes as antibacterial agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/76173/.

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Novel photoactive ruthenium(II) complexes were designed to incorporate existing anti-tuberculosis drugs, isoniazid and nicotinamide, that could be released from the ruthenium(II) cage by photoactivation with visible light. Two sets of complexes were synthesised based on cis-[Ru(N-N')2(L)2][PF6]2and cis-[Ru(N-N')2(L)X][PF6], where N-N' is 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen), L is isoniazid (INH) or nicotinamide (NA) and X is either Cl or I. Their dynamic behaviour in solution was explored using NMR to probe the presence of atropisomers. In the case of cis-[Ru(bpy)2(NA)Cl][PF6] (

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6

Nielsen, Elisabet I. "Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144909.

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Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. This thesis focuses on the development and evaluation of pharmacometric models that can be used as tools in the establishment of improved dosing strategies for novel and already clinically available antibacterial drugs. Infectious diseases are common causes of death in preterm and term newborn infants. A population pharmacokinetic (PK) model for gentamicin was developed

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7

Das, Sanjan Kumar. "Application of Structural Genomics for Developing Novel Antibacterial Agents." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486462.

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The structure-based design of novel antibiotics has great potentiaL To achieve this goal the first step is to gather structural information on relevant proteins and utilise this to find inhibitors through a process of screening and subsequent optimising using structural data. In thisÃ‚Â· pilot study a number of essential gene products from Bacillus subtilis were targeted for structural studies where homologues were present in pathogenic microorganisms. In the initial analysis 41 essential genes of unknown structure or function were selected for structure determination. From this list 9 genes w

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8

Griffiths, Jennifer Mary. "Model systems to investigate bacterial persistence to antibacterial agents." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590484.

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Bacterial persistence describes the phenotypic variation displayed by clonal bacterial populations which permits a small fraction of cells to survive exposure to antimicrobials. The phenomenon was first described in the 19405 by Joseph Bigger who observed that penicillin could not sterilize a culture of Staphylococcus aureus. The surviving cells were not resistant mutants as they displayed equal susceptibility to penicillin as the parent population upon subculture. Among the various hypotheses which have been proposed to explain this phenomenon, the majority consider persisters to be dormant T

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9

Carraco, Moreira Joao Bruno. "Characterisation of symmetric bis-benzimidazoles as antibacterial chemotherapeutic agents." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579712.

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Nosocomial and community-acquired infections due to methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria are associated with high levels of mortality, morbidity and significant social and economic costs in the U.K. and elsewhere. As the evolution of multi-drug resistance relentlessly erodes the utility of currently available antibacterial drugs, it is essential to maintain efforts to search for new classes of antibacterial agents. Benzimidazoles are potent antihelmintic agents discovered in 1961. Chemical modifications led to the synthesis of the head-to-tail flu

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10

Lam, Chi-wah. "Antibacterial effects of nanoparticles on cariogenic organisms /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31490414.

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11

Ismaeel, N. A.-A. "Resistance of Providencia stuartii to chlorhexidine and other antibacterial agents." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376556.

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12

Baguley, Christina Birgit. "The structure and activity of #beta#-lactamase I from Bacillus cereus." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279880.

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13

O'Leary, Ruth. "Investigation into the modification of the A-ring of analogues of 4-quinolones." Thesis, University of Strathclyde, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303283.

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14

Shojaee, Aliabadi Fariborz. "Danofloxacin pharmacodynamic and pharmacokinetic interrelationships in ruminant species." Thesis, Royal Veterinary College (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266348.

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15

Miller, Chandra Tier. "The design, synthesis and screening of naphthalene diimides with antibacterial activity /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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16

Hendry, Maureen M. "The efficacy of topical honey to heal wounds and burns : systematic review and meta-analysis /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16941.pdf.

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17

林志華 and Chi-wah Lam. "Antibacterial effects of nanoparticles on cariogenic organisms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45007743.

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18

Acquaah-Harrison, George. "Antibacterial Agents: 1,4-Disubstituted 1,2,3-Triazole Analogs of the Oxazolidinone." Ohio : Ohio University, 2010. http://www.ohiolink.edu/etd/view.cgi?ohiou1273250347.

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19

Jackson, Andrew Edward. "A novel approach to #beta#-lactam and quinolone antibacterial agents." Thesis, University of Sunderland, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242127.

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The f)-lactam or azetidinone 4-membered heterocyclic nng system has been synthesised by many different synthetic strategies and these are well documented in the literature. Many of these strategies give substituted azetidinone rings displaying defined stereochemistry which are used as the building block for many modern day antibiotics. It was therefore intended to pursue a method of azetidinone ring formation using cheap and readily available starting materials employing a [2+2] cycloaddition reaction which, according to the literature, had only a few examples and was seen to be an area ripe f

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20

Salama, Fatma Ibrahim Khalifa. "Exploring the potential of Affimer artificial antibodies as antibacterial agents." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19935/.

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21

Glansdorp, Freija Gwendolyn. "Chemical studies into novel modes of action of antibacterial agents." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611932.

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22

Kasturiarachchi, Jagath Chandana. "Bio-oligomers as antibacterial agents and strategies for bacterial detection." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10030.

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In this thesis I examined the potential of Bio-Oligomers such as peptoids, peptides and aptamers, as therapeutic and diagnostic entities. Therapeutic Bio-Oligomers; A series of peptoid analogs have been designed and synthesised using solid phase synthesis. These peptoids have been subjected to biological evaluation to determine structure-activity relationships that define their antimicrobial activity. In total 13 peptoids were synthesised. Out of 13 different peptoids, only one peptoid called Tosyl-Octyl-Peptoid (TOP) demonstrated significant broad-spectrum bactericidal activity. TOP kills bac

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23

Carrick, Christopher. "Exploiting bacterial transporters for the design of novel antibacterial agents." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6533/.

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The alarming increase in the occurrence of antimicrobial resistance has led to a situation whereby some strains are untreatable by known antimicrobials. The Trojan horse strategy is one methodology with the potential to overcome the rising tide of resistance. Work was undertaken to synthesise two different Trojan horses. One based on an analogue of the Bacillus siderophore petrobactin, the other a novel compound prepared using the Ugi four component condensation. Both contained a fluoroquinolone antimicrobial; ciprofloxacin. Additionally a series of bis-catecholate ligands were prepared for us

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24

Zhang, Jianjun. "Library Synthesis of Anticancer and Antibacterial Agents via Azide Chemistry." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/711.

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Various anticancer and antibacterial agents have been synthesized via azide chemistry by taking advantage of carbohydrate. Starting from the synthesis of 14 glycosyl azides, a library of carbohydrate-oxazolidinone conjugates and a library of carbohydrate-cyclopamine conjugates with biological interests were synthesized based on a highly efficient "click reaction" assisted by sonication. Some of the conjugates have improved solubility and enhanced anticancer activity. A library of neomycin B derivatives with various modifications at the 5" position has been synthesized. Two leads exhibit

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25

Chiodini, G. "SYNTHESIS AND DEVELOPMENT OF NEW ANTIBACTERIAL AGENTS INHIBITORS OF FTSZ." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232409.

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Elements of the bacterial cytoskeleton represent potential targets for antimicrobial compounds. FtsZ (Filamentous temperature sensitive Z) is a bacterial ancestor of eukaryotic tubulin. It possess markedly different structures than its eukaryotic analogue, making possible to develop specific inhibitors for the bacterial protein. The 3-methoxybenzamide (3-MBA) has a weak antibacterial activity against B. subtilis, it can easily penetrate bacterial cell and bind FtsZ at high ligand efficiency. The fluorinated 3-MBA analogue 2,6-difluoro-3-nonyloxybenzamide (compound 1) showed a significant activ

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26

Tshanga, Siphokazi Sisanda. "Antibacterial activity of liposome encapsulated cyclo(TYR-PRO)." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1450.

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Cyclic dipeptides (CDPs) are amino acid-based compounds, some of which possess antibacterial activity. The encapsulation of certain drugs into liposomes has been found to improve their activity in terms of bioavailability and duration of action. Liposomes are small vesicles that are under investigation as drug carriers for the delivery of therapeutic agents. A number of liposome formulations are currently under clinical trial review, whilst some have already been approved for clinical use. The aim of this study was to optimize a liposomal cyclo(Tyr-Pro) formulation and to assess its antibacter

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27

Shapiro, Elyse M. "Optimizing Escherichia coli for the detection of antimicrobial compounds /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9916.

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28

Spencer, William T. "Part I, studies toward the total synthesis of Trocheliophorolide A. ; part II, studies on the development of a palladium-catalyzed carbonylative cross-coupling towards the synthesis of alkenyl alkynyl ketones /." Online version of thesis, 2008. http://hdl.handle.net/1850/7729.

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29

Rigoreau, Laurent Jean Martin. "The synthesis of Î²-Sultams." Thesis, University of Huddersfield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323939.

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30

El-Falaha, B. M. A. "Resistance to antibacterial agents : studies with Escherichia coli and Pseudomonas aeruginosa." Thesis, Cardiff University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304154.

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31

Ella-Menye, Jean-Rene. "Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/611.

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Small chiral molecules are very important building blocks in the synthesis of biologically active compounds. These building blocks include nitrogen and oxygen-containing heterocycles such as 2-oxazolidinones, 1,3-oxazinan-2-ones, 2-oxazolines, oxazines, morpholine and morpholinones. Because of their interesting properties, chiral heterocycles have stirred great interest in the synthetic chemist community to develop useful and efficient strategies to these molecules. In this dissertation, the design and syntheses of various heterocyclic building blocks are presented, as well as the testing of t

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32

Doss, Sally. "The role of antibacterial agents on the pathogenicity of Staphylococcus aureus." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19698.

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<i>Staphylococcus aureus</i> is a pathogenic bacterium which has an impressive armoury of extracellular toxic factors. In recent years, <i>S. aureus</i> has developed resistance to the new 4-quinolone antibacterials. Since this resistance is a result of a chromosomal mutation, it was proposed that the resistant bacteria might be less pathogenic. This thesis has studied this postulate. Ciprofloxacin sensitive and resistant strains of <i>S.aureus</i> were compared to establish any differences in their respective production of virulence factors both <i>in vitro</i> and <i>in vivo</i>. Since <i>S.

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33

Bandara, Bandarage Mahesh Kithsiri Optometry &amp Vision Science Faculty of Science UNSW. "Investigation and characterisation of antibacterial properties of non-steroidal anti-inflammatory drugs." Awarded by:University of New South Wales. School of Optometry and Vision Science, 2005. http://handle.unsw.edu.au/1959.4/22284.

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Microbial contamination of contact lenses is a significant risk factor leading to adverse responses. Adhesion of microorganisms to a contact lens is the first step in a series of events that leads to contact lens-related infections or inflammation. Recently, some of the non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to have the ability to interfere with microbial biofilm formation. In this project, antibacterial properties of commonly used NSAIDs (salicylic acid, sodium diclofenac and ketorolac) were assessed and characterised using biological assays and molecular biological te

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34

Carlsson, Stefan. "Antibacterial effects of nitrite in urine /." Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-237-3.

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35

Singh, G. "Antibacterial activity testing of cotton medical textiles sonochemically impregnated with metal oxide nanoparticles." Thesis, Coventry University, 2014. http://curve.coventry.ac.uk/open/items/edeb833b-a792-49eb-bc22-bafbd374bb22/1.

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The Sonochemistry Centre at Coventry University is one of a group of organisations working on a project to develop a new technology for producing antimicrobial textiles. This technology involves the use of an ultrasonic process (sonochemical) to generate and impregnate fabrics with antibacterial metal oxide nanoparticles. The expectation is that these textiles can be produced at an affordable price for routine use in hospitals as uniforms, curtains, hospital bed sheets and linen. The aim of this PhD project was to assess the antibacterial activity of fabrics impregnated with ZnO and CuO NPs ag

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36

Mbere, Johana M. "Development of new benzo[b]thiophene amide-based antimicrobial agents." Department of Chemistry - Faculty of Science, 2005. http://ro.uow.edu.au/theses/396.

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The overall aim of this project was to investigate the synthesis and activity of a range of compounds based on the benzo[b]thiophene-2-carboxamide structural motif as potential new antimalarial agents, and to a lesser extent as antibacterial agents.In order to subsequently explore any structure-biological activity relationships, the first part of the project involved the systematic synthesis of some 39 non-fused substituted benzo[b]thiophene amide derivatives including tetrahydroisoquinolines, tetrahydro-β-carbolines, dihydropyrroles, piperazines, piperidines and other bridged ring systems as

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37

Clarke, Annette June Morgan. "The physical characterization and antibacterial activity of herring protamines." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0029/MQ47419.pdf.

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38

Fleeman, Renee. "Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6839.

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Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to all treatment options available. In 2014, the World Health Organization announced that this problem is driving us towards a “post-antibiotic era” that will change the face of modern medicine as we know it. If lack of novel antibiotic development and FDA approval continues, by the year 2050, 10 million people will die each year to an antimicrobial resistant bacterial infection. With lack of pharmaceutical industry involvement in developing

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39

Provost, Paul Graham. "The persistence and effects of antibacterial agents in marine fish farm sediments." Thesis, Edinburgh Napier University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369173.

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40

Pan, Po-Shen. "Synthesis of macrocycles and their biological evaluation as antitumor and antibacterial agents." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3320912.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2008.<br>Title from first page of PDF file (viewed October 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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41

Meng, Fan Cheng. "Chemical constituents from the rhizome of coptis chinensis and their antibacterial activities." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953272.

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42

Mariner, Katherine Ruth. "The activity, mode of action and generation of resistance to novel antibacterial agents." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659123.

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The failure of antibiotics to treat infections caused by multi-drug resistant bacteria is a significant problem in the field of antimicrobial chemotherapy. The characterisation and development of antibacterial agents displaying novel modes of action (MOAs) or the modification of existing antibiotic scaffolds may address this problem. This study therefore sought to identify antibiotic candidates, establishing their antibacterial activity, bacterial specificity, MOA and propensity for resistance development. From nearly half a million compounds which were screened in silica against RNA polymeras

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43

Gonciarz, Ryan Lennox. "Broadening the spectrum of antibacterial agents to tackle multidrug-resistant Gram-negative pathogens." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22308/.

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Antimicrobial resistance is one of the greatest threats to human health in the 21st century: particularly resistance amongst Gram-negative bacteria. The work presented herein aims to identify new agents that target drug-resistant Gram-negative pathogens such as E. coli, through the rational modification of the oxazolidinone class of antibiotics. This class, exemplified by linezolid, is well validated for treating Gram-positive derived infections, but lacks clinically-useful activity against Gram-negative bacteria. An integrated approach encompassing structure-based drug design, organic synthes

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44

Paula-Eduardo, Laila Facin de 1984. "Isolamento e identificação de compostos bioativos da geoprópolis (Melipona scutellaris) bioguiado pelo efeito antimicrobiano = Isolation and identification of bioactive compounds of geopropolis (Melipona scutellaris) bioguided by the antimicrobial effect." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288513.

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Orientadores: Pedro Luiz Rosalen, Cínthia Pereira Machado Tabchoury<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-26T11:28:01Z (GMT). No. of bitstreams: 1 Paula-Eduardo_LailaFacinde_M.pdf: 1396217 bytes, checksum: ee32ae3fccb5fc73fe047b8152a78b6e (MD5) Previous issue date: 2014<br>Resumo: Os produtos naturais, comprovadamente, têm sido uma fonte promissora para descoberta de novos compostos bioativos. Dentre eles, a própolis coletada por abelhas Apis mellifera possui atividades biológicas descritas

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Riesbeck, Kristian. "Effects of fluoroquinolones on the immune system." Malmö : Dept. of Medical Microbiology, Lund University, Malmö General Hospital, 1994. http://books.google.com/books?id=-hRtAAAAMAAJ.

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46

Martini, Nataly Dominica. "The isolation and characterisation of antibacterial compounds from Combretum erythrophyllum (Burch.) Sond." Diss., Pretoria : [s.n.], 2001. http://upetd.up.ac.za/thesis/available/etd-07092002-153815/.

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Moro, Whitney Beysselance. "The design and synthesis of antibacterial inhibitors of NAD synthetase." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/moro.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2007.<br>Title from PDF title page (viewed Feb. 4, 2010). Additional advisors: Subramaniam Ananthan, David E. Graves, Craig D. Smith, Sadanandan E. Velu. Includes bibliographical references.

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48

Lo, Shiu-hong. "Antibacterial activity of some marine planktonic algae in Hong Kong /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19667152.

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49

Sitnikov, Dmitri. "Toxicity and adsorbance abilities of Alcell lignin to bacteria." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29807.

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AlcellRTMlignin has been used commercially in adhesive preparation and brake pad linings and experimentally in animal feeds to reduce or eliminate diarrheal attacks in farm animals. Our study dealt with elucidating the antibacterial effect of AlcellRTMlignin. It would appear that adsorbance of E. coli cells to AlcellRTMlignin particles is not essential for destruction of the organism.<br>The antibacterial activity was delayed by the inclusion of Mg 2+ ions in the AlcellRTMlignin filtrate or in the enumeration medium (BHIA). Addition of bile salts to the enumeration medium (BHIA) enhanced the c

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50

Messina, Maria Cipolla 1961. "The effect of liquid smoke on Listeria monocytogenes." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276677.

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Four strains of Listeria monocytogenes (LCDC 81-861, ATCC 19115, M1 and M2) examined in pure culture behaved similarly when exposed to a concentration of 0.5% CharSol C-10 liquid smoke by reducing Listeria numbers to an undetectable level within 4 hours post treatment. However, at the lower concentration of 0.25% liquid smoke, differences in resistance to the antimicrobial properties of smoke components become evident among these strains indicating that a level of 0.5% liquid smoke is more effective in controlling this organism. CharSol C-10 liquid smoke was used as a full strength dip treatme

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