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Journal articles on the topic 'Antibacterial antibiotics'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Abedon, Stephen T. "Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?" Antibiotics 8, no. 4 (2019): 182. http://dx.doi.org/10.3390/antibiotics8040182.

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Bacteria can evolve resistance to antibiotics. Even without changing genetically, bacteria also can display tolerance to antibiotic treatments. Many antibiotics are also broadly acting, as can result in excessive modifications of body microbiomes. Particularly for antibiotics of last resort or in treating extremely ill patients, antibiotics furthermore can display excessive toxicities. Antibiotics nevertheless remain the standard of care for bacterial infections, and rightly so given their long track records of both antibacterial efficacy and infrequency of severe side effects. Antibiotics do

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2

Bojarski, Bartosz, Barbara Kot, and Małgorzata Witeska. "Antibacterials in Aquatic Environment and Their Toxicity to Fish." Pharmaceuticals 13, no. 8 (2020): 189. http://dx.doi.org/10.3390/ph13080189.

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Antibacterial agents are commonly present in aquatic environment at low concentrations. Terrestrial animal farms, human medicine and aquaculture are main sources of water contamination with antibacterials. Antibiotics were proved to be directly toxic to fish causing oxidative stress, general stress response, histopathological lesions, hematological, metabolic, and reproductive disorders, as well as immunosuppressive and genotoxic effects. Environmentally realistic low concentrations of antibiotics also disturb aquatic bacterial communities causing alterations in fish symbiotic microbiota and i

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Skadiņš, Ingus, Juta Kroiča, Ilze Salma, Aigars Reinis, Marina Sokolova, and Dagnija Rostoka. "Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 73, no. 2 (2019): 177–84. http://dx.doi.org/10.2478/prolas-2019-0028.

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Abstract Local antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In this in vitro study, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa was studied by evaluating the expression of infl

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4

Zhao, ChuanXin, QiaMin Gu, GaoYun Chen, MengBin Yu, and Min Liu. "Research progress of carbon based nanoenzyme and composites in antibacterial field." E3S Web of Conferences 267 (2021): 02057. http://dx.doi.org/10.1051/e3sconf/202126702057.

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Due to the abuse of antibiotics, more and more bacteria are resistant to antibiotics. Non antibiotic nano antibacterial materials emerge as the times require. Carbon based nano enzyme is an efficient and environmentally friendly antibacterial material with certain antibacterial effect. It has simple structure and good compatibility. It can be combined with a variety of antibacterial substances to form composite antibacterial materials, expand the scope of antibacterial and improve the antibacterial ability. This paper summarizes the research progress of three kinds of carbon based nanoenzymes

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Al-Mogbel, Mohammed S., Godfred A. Menezes, Mohamed T. Elabbasy, Manal M. Alkhulaifi, Ashfaque Hossain, and Mushtaq A. Khan. "Effect of Synergistic Action of Bovine Lactoferrin with Antibiotics on Drug Resistant Bacterial Pathogens." Medicina 57, no. 4 (2021): 343. http://dx.doi.org/10.3390/medicina57040343.

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Background and Objectives: The multidrug resistant (MDR) bacterial pathogenic infection is one of the chief worldwide public health threat to humanity. The development of novel antibiotics against MDR Gram negative bacteria has reduced over the last half century. Research is in progress regarding the treatment strategies that could be engaged in combination with antibiotics to extend the duration of these life-saving antibacterial agents. The current study was therefore planned to assess the synergistic effects of bovine lactoferrin (bLF) in combination with different antibiotics that are conv

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6

Lucas, Jane M., Evan Gora, Annika Salzberg, and Michael Kaspari. "Antibiotics as chemical warfare across multiple taxonomic domains and trophic levels in brown food webs." Proceedings of the Royal Society B: Biological Sciences 286, no. 1911 (2019): 20191536. http://dx.doi.org/10.1098/rspb.2019.1536.

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Bacteria and fungi secrete antibiotics to suppress and kill other microbes, but can these compounds be agents of competition against macroorganisms? We explore how one competitive tactic, antibiotic production, can structure the composition and function of brown food webs. This aspect of warfare between microbes and invertebrates is particularly important today as antibiotics are introduced into ecosystems via anthropogenic activities, but the ecological implications of these introductions are largely unknown. We hypothesized that antimicrobial compounds act as agents of competition against in

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7

Miladinović, Dragoljub L., Budimir S. Ilić, and Branislava D. Kocić. "Chemoinformatics Approach to Antibacterial Studies of Essential Oils." Natural Product Communications 10, no. 6 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000667.

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The chemical composition and antibacterial activity of Nepeta nuda (Lamiaceae) essential oil were examined, as well as the association between it and standard antibiotics: tetracycline and streptomycin. The antibacterial activities of 1,8-cineole, the main constituent of N. nuda oil, individually and in combination with standard antibiotics were also determined. The interactions of the essential oil and 1,8-cineole with antibiotics toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemoinformatics methods. Oxygenated monoterpenes were th

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8

Ziemska, Joanna, Aleksandra Rajnisz, and Jolanta Solecka. "New perspectives on antibacterial drug research." Open Life Sciences 8, no. 10 (2013): 943–57. http://dx.doi.org/10.2478/s11535-013-0209-6.

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AbstractBacterial resistance to commonly used antibiotics is constantly increasing. Bacteria particularly dangerous for human life are methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium and fluoroquinolone-resistant Pseudomonas aeruginosa. Hence, there is an incessant need for developing compounds with new modes of action and seeking alternate drug targets. In this review, the authors discuss the current situation of antibacterial medicines and present data on new antibiotic targets. Moreover, alternatives to antibiotics, such as bacteriophages, antimicrobia

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9

Preobrazhenskaya, M. N., O. V. Miroshnikova, A. Yu Pavlov, and E. N. Olsuf'eva. "Antibacterial glycopeptide antibiotics (review)." Chemistry of Heterocyclic Compounds 34, no. 12 (1998): 1359–81. http://dx.doi.org/10.1007/bf02317806.

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10

Yasrebi, Kaveh, Nico Schade, Emmanuel Tola Adeniyi, et al. "Novel effective antibacterial small-molecules against Staphylococcus and Enterococcus strains." Future Medicinal Chemistry 12, no. 13 (2020): 1205–11. http://dx.doi.org/10.4155/fmc-2020-0010.

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Background: Resistance developments against established antibiotics are an emerging problem for antibacterial therapies. Novel antibiotics are urgently needed. Materials & methods: We developed novel small-molecule antibacterials which are easily accessible in a simple one-pot synthesis. The central cyclopentaindole core is substituted with two indole residues. Various indole and cyclopentane substituents have been introduced. Additionally, first indole substituted propene compounds as ring-open variants of the cyclopentaindoles have been yielded and evaluated as antibacterials against Sta

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11

Woziwodzka, Anna, Marta Krychowiak-Maśnicka, Grzegorz Gołuński, et al. "Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation." Molecules 26, no. 12 (2021): 3628. http://dx.doi.org/10.3390/molecules26123628.

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Antimicrobial resistance is a major healthcare threat globally. Xanthines, including caffeine and pentoxifylline, are attractive candidates for drug repurposing, given their well-established safety and pharmacological profiles. This study aimed to analyze potential interactions between xanthines and aromatic antibiotics (i.e., tetracycline and ciprofloxacin), and their impact on antibiotic antibacterial activity. UV-vis spectroscopy, statistical-thermodynamical modeling, and isothermal titration calorimetry were used to quantitatively evaluate xanthine-antibiotic interactions. The antibacteria

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BiBi, Tayyaba, and Taj Muhammad Khan. "Assessment of engineered nanosilver as an alternative nano-antibiotic in marine water pollution using biomarker of fish cell line." Toxicology Research and Application 5 (January 1, 2021): 239784732199828. http://dx.doi.org/10.1177/2397847321998282.

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A large volume of antibiotics is used in fish farms to treat diseases because the farmed fish are fully affected by diseases and parasites in the aquaculture and particularly in the ocean environment where disease pathogens multiply quickly. The frequent use of these antibiotics in aquaculture has resulted in animal; stress, infection, and their dissemination in the form of antibiotic resistant genes to other bacteria including human and animal pathogens. The problems arising with antibiotics can be overcome by using silver nanoparticles (AgNPs) due to their physiochemical properties and low t

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Shkil, N. N., and E. V. Nefedova. "Influence of antibiotics and silver nanoparticles on the change of sensitivity of E. coli to antibacterial drugs." Siberian Herald of Agricultural Science 50, no. 2 (2020): 84–91. http://dx.doi.org/10.26898/0370-8799-2020-2-10.

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Research has been conducted to evaluate the effect of antibiotics and silver nanoparticles in combination with antibiotics on the change in antibiotic sensitivity to antibacterial drugs of E. coli ATCC 25922 reference strain and its isolate. Nanoparticles obtained by electron beam treatment of aqueous solution containing water-soluble stabilizing polymer and water-soluble silver salt were used in the experiment. During the treatment a beam of accelerated electrons obtained on the installation of a linear accelerator of the ILU-10 type passed through a solution with a working dose of 5–30 kGy r

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14

Rotaru, Luciana Teodora. "Correlation of the Theoretical Study with the Experimental Determination of the Antibacterial Effect of Vaccinium myrtillus folium (VM-f) Plant Extract." Revista de Chimie 70, no. 3 (2019): 990–92. http://dx.doi.org/10.37358/rc.19.3.7046.

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The last century was marked by efforts to search for natural compounds with antibacterial therapeutic properties, due to the gradual reduction of the number of effective allopathic antibiotics and on the toxic effects of antibiotic residues in animal products. Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in the treatment of antibiotic-resistant bacteria. We determined the polyphenolic composition of the tested plant extract by HPLC technique. The aim of this study was to evaluate the antibacterial activity of Vaccinum myrtillu

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15

Singh, Pawan, Navneet Verma, Prevesh Kumar, and Priynaka Nagu. "REVIEW ON A POTENTIAL OF ANTIBIOTICS." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 35–40. http://dx.doi.org/10.22270/jddt.v8i5-s.1936.

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Observations about the growth of some microorganisms inhibiting the growth of other microorganisms have been reported since the late 1800s. These observations of antibiosis between microorganisms led to the discovery of natural antibacterial. This paper deliberates important findings of the educations conducted by numerous national and international combined organizations on a brief indication of the antibacterial agents׳ detection in recent years. In India especially the developing antibiotics, need to institute methods for the suitable choice of drug conduct a compound problem involving pres

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16

Kulagina, Lyudmila Yurievna, Albina Ayratovna Zvegintseva, Alina Garafutdinovna Zamalutdinova, and Maksim Leonidovich Maksimov. "The features of antibacterial therapy in children." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 5 (May 1, 2021): 52–67. http://dx.doi.org/10.33920/med-10-2105-06.

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At present, the use of antibacterial drugs is one of the most frequently recommended methods of treating a large number of infectious diseases. However, in clinical practice, excessive use of antibiotics, unreasonable antibiotic therapy, and inappropriate combinations are quite common, which creates the risk of unwanted side effects, increases the cost of treatment and leads to an increase in microorganism resistance. That is why, in modern medicine, the problem of rational antibiotic therapy, i.e. the adequate use of antibacterial drugs, compliance with strict indications for their use, certa

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17

Tao, Ran, Chengzhang Wang, Jianzhong Ye, Hao Zhou, and Hongxia Chen. "Polyprenols ofGinkgo bilobaEnhance Antibacterial Activity of Five Classes of Antibiotics." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/4191938.

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Polyprenol (GBP) fromGinkgo bilobaLeaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And we studied the time-killing curves and Ca2+mobilization assay inStaphylococcus aureuscells treated with GBP microemulsion and gentamicin sulfate under MIC/2 conditions. These results showed that the GBP microemulsion (average diameter 90.2 nm) combining with gentamicin sulfate had the highest enhancing antibacterial effect againstStaphyl

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18

Alam, Mohammad Morshad, Muzahidul Islam, Abrar Wahab, and Mamun Billah. "Antimicrobial Resistance Crisis and Combating Approaches." Journal of Medicine 20, no. 1 (2019): 38–45. http://dx.doi.org/10.3329/jom.v20i1.38842.

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Antimicrobial resistance is a major global public health challenge threatening the utility of antibiotics. Inappropriate antibiotic prescribing and sales, using outside of the health sectors, and genetic factors are mainly influencing the development of antimicrobial resistance (AMR). Antibiotics abuse in human, wildlife, and farming practices have an enormous health impact. Recently approved antibiotics are anticipated to help stem this crisis. To fight against antibiotic resistance crisis, development of collaboration among concerned stakeholders to establish policies, initiatives, and inves

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19

Chang, Yuhan, Wen-Chien Chen, Pang-Hsin Hsieh, et al. "In VitroActivities of Daptomycin-, Vancomycin-, and Teicoplanin-Loaded Polymethylmethacrylate against Methicillin-Susceptible, Methicillin-Resistant, and Vancomycin-Intermediate Strains of Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 55, no. 12 (2011): 5480–84. http://dx.doi.org/10.1128/aac.05312-11.

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ABSTRACTThe objective of this study was to evaluate the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with daptomycin, vancomycin, and teicoplanin against methicillin-susceptibleStaphylococcus aureus(MSSA), methicillin-resistantStaphylococcus aureus(MRSA), and vancomycin-intermediateStaphylococcus aureus(VISA) strains. Standardized cement specimens made from 40 g PMMA loaded with 1 g (low-dose), 4 g (middle-dose) or 8 g (high-dose) antibiotics were tested for elution characteristics and antibacterial activities. The patterns of release of antibiotics from the cemen

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20

David, Akinwale Ajayi, Shang Eun Park, Keykavous Parang, and Rakesh Kumar Tiwari. "Antibiotics-Peptide Conjugates Against Multidrug-resistant Bacterial Pathogens." Current Topics in Medicinal Chemistry 18, no. 22 (2019): 1926–36. http://dx.doi.org/10.2174/1568026619666181129141524.

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The menace of multi-drug resistance by bacterial pathogens that are responsible for infectious diseases in humans and animals cannot be over-emphasized. Many bacteria develop resistance to antibiotics by one or more combination of resistance mechanisms namely, efflux pump activation thereby reducing bacteria intracellular antibiotic concentration, synthesizing a protein that protects target site causing poor antibiotic affinity to the binding site, or mutations in DNA and topoisomerase gene coding that alters residues in the binding sites. The ability to use a combination of these resistance m

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21

Feier, Andrei-Marian, Andrei-Constantin Ioanovici, Radu-Cristian Ionescu, Tamas Toth, and Octav-Marius Russu. "Biofilm Inhibition: Compounds with Antibacterial Effects." Journal of Interdisciplinary Medicine 3, no. 4 (2018): 234–38. http://dx.doi.org/10.2478/jim-2018-0042.

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Abstract Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a ma

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22

Pancu, Daniel Florin, Alexandra Scurtu, Ioana Gabriela Macasoi, et al. "Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening." Antibiotics 10, no. 4 (2021): 401. http://dx.doi.org/10.3390/antibiotics10040401.

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Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to the infectious diseases problem. However, the excessive use of antibiotics worldwide has generated a critical public health issue and the bacterial resistance correlated with antibiotics inefficiency is still unsolved. Finding novel therapeutic approaches to overcome bacterial resistance is imperative, and natural compounds with antibacterial effects could be considered a promising option. The role played by antibiotics in tumorigenesis and their interrelation with the microbiota are sti

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23

Khojah, Hani M. J., Hosam G. Abdelhady, Abdulmalik A. Alqurashi, et al. "Parental awareness regarding pediatric antibiotic use in Madinah, Saudi Arabia." Tropical Journal of Pharmaceutical Research 19, no. 2 (2020): 411–19. http://dx.doi.org/10.4314/tjpr.v19i2.25.

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Purpose: To determine the level of awareness of antibiotic use in children in Madinah, Saudi Arabia, and to identify factors associated with parental decisions regarding it. Methods: Using a multiple-choice-question-based questionnaire survey, 1256 forms were distributed to visitors of major shopping malls in Madinah City to obtain socio-demographic and antibiotics knowledgebased data from October 2017 to January 2018. Differences in scores between and within groups on knowledge of parents about antibiotics were determined. Results: Most participants (67 %) had good basic knowledge

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24

Kumar, Ravi Ranjan, and Vasantba J. Jadeja. "Characterization and partial purification of an antibacterial agent from halophilic actinomycetes Kocuria sp. strain rsk4." BioImpacts 8, no. 4 (2018): 253–61. http://dx.doi.org/10.15171/bi.2018.28.

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Introduction: The inevitable rise of antibiotic-resistant bacteria is a global health problem. These pathogens erode the utility of available antibiotics. Staphylococcus aureus is one of the major causes of community-acquired infections. The aim of work was to evaluate the marine actinomycetes for production of the antibacterial agent against pathogens. Methods: Halophilic actinomycetes were isolated, characterized and screened for production of antibacterial agent against pathogenic bacteria. The antibacterial compounds were extracted by solvent extraction and separated by TLC based bioautogr

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Amos-Tautua, Bamidele, Sandile Songca, and Oluwatobi Oluwafemi. "Application of Porphyrins in Antibacterial Photodynamic Therapy." Molecules 24, no. 13 (2019): 2456. http://dx.doi.org/10.3390/molecules24132456.

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Antibiotics are commonly used to control, treat, or prevent bacterial infections, however bacterial resistance to all known classes of traditional antibiotics has greatly increased in the past years especially in hospitals rendering certain therapies ineffective. To limit this emerging public health problem, there is a need to develop non-incursive, non-toxic, and new antimicrobial techniques that act more effectively and quicker than the current antibiotics. One of these effective techniques is antibacterial photodynamic therapy (aPDT). This review focuses on the application of porphyrins in

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26

Kępa, Małgorzata, Maria Miklasińska-Majdanik, Robert D. Wojtyczka, et al. "Antimicrobial Potential of Caffeic Acid againstStaphylococcus aureusClinical Strains." BioMed Research International 2018 (July 15, 2018): 1–9. http://dx.doi.org/10.1155/2018/7413504.

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Phenolic compounds constitute one of the most promising and ubiquitous groups with many biological activities. Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective of the presented study was to assess the antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination againstStaphylococcus aureusreference and clinical strains isolated from infected wounds. The caffeic acid tested in the presented study showed diverse effects onS.

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27

Jones, Dan B. "New Horizons in Antibacterial Antibiotics." International Ophthalmology Clinics 33, no. 1 (1993): 179–86. http://dx.doi.org/10.1097/00004397-199303310-00015.

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28

Preobrazhenskaya, M. N., O. V. Miroshnikova, A. Yu Pavlov, and E. N. Olsufyeva. "ChemInform Abstract: Antibacterial Glycopeptide Antibiotics." ChemInform 30, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.199917308.

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Rotella, Madeline, Alicia Briegel, John Hull, Anthony Lagalante, and Robert Giuliano. "Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers." Journal of Nanomaterials 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/204961.

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Surface functionalization of nanomaterials is an area of current investigation that supports the development of new biomaterials for applications in biology and medicine. Herein we describe the synthesis, characterization, and antibacterial properties of the first examples of antibiotic-labeled graphitic carbon nanofibers (GCNFs) covalently functionalized with aminoglycoside and quinolone antibiotics. Ruthenium tetroxide oxidation of herringbone GCNFs gave higher amounts of surface carboxyl groups than previous methods. These carboxyl groups served as sites of attachment for antibiotics by acy

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Ilizirov, Yana, Andrei Formanovsky, Irina Mikhura, Yossi Paitan, Faina Nakonechny, and Marina Nisnevitch. "Effect of Photodynamic Antibacterial Chemotherapy Combined with Antibiotics on Gram-Positive and Gram-Negative Bacteria." Molecules 23, no. 12 (2018): 3152. http://dx.doi.org/10.3390/molecules23123152.

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The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitiv

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Hoffman, Paul S. "Antibacterial Discovery: 21st Century Challenges." Antibiotics 9, no. 5 (2020): 213. http://dx.doi.org/10.3390/antibiotics9050213.

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It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended; yet, we still struggle to identify novel drug targets and to deliver new chemical classes of antibiotics to replace those rendered obsolete by drug resistance. Despite herculean efforts utilizing a wide range of antibiotic discovery platform strategies, including genomics, bioinformatics, systems biology and postgenomic approaches, success has been at best incremental. Obviously, finding new classes of antibiotics is really hard, so repeating the old strategies, while expecting different outcomes, seems

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Vassallo, Antonio, Maria Francesca Silletti, Immacolata Faraone, and Luigi Milella. "Nanoparticulate Antibiotic Systems as Antibacterial Agents and Antibiotic Delivery Platforms to Fight Infections." Journal of Nanomaterials 2020 (September 12, 2020): 1–31. http://dx.doi.org/10.1155/2020/6905631.

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Today’s human society, product of decades of progress in all fields of knowledge, would have been unimaginable without the discovery of antibiotics and more generally of antimicrobials. However, from the beginning, the scientific community was aware that microorganisms through various strategies were able to hinder and render vain antibiotic action. Common examples are the phenomena of persistence, tolerance, and resistance, up to the creation of the feared bacterial biofilms. Antibiotics are a precious but equally labile resource that must be preserved but at the same time reinforced to safeg

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de Araújo, Rodrigo Santos Aquino, José Maria Barbosa-Filho, Marcus Tullius Scotti, et al. "Modulation of Drug Resistance inStaphylococcus aureuswith Coumarin Derivatives." Scientifica 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6894758.

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Semisynthetic and commercial coumarins were investigated for their antibacterial and adjuvant properties with antibiotic agents against norfloxacin, erythromycin, and tetracycline resistantStaphylococcus aureusas based on efflux mechanisms. The coumarins and certain commercial antibiotics had their Minimum Inhibitory Concentrations determined by broth microdilution assay against resistantS. aureusstrains which overexpress efflux pump proteins. For evaluation of the modulatory activity, the antibiotics MICs were determined in the presence of the coumarin derivatives at subinhibitory concentrati

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Areej, Sadaf, Adeel Sattar, Aqeel Javeed, and Sohail Raza. "Diphenhydramine and levofloxacin combination therapy against antimicrobial resistance in respiratory tract infections." Future Microbiology 16, no. 6 (2021): 409–20. http://dx.doi.org/10.2217/fmb-2019-0346.

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Background: Antibiotics are in use since decades to treat various infections caused by Gram-positive and Gram-negative bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. Diphenhydramine, an H1 receptor blocker possesses a weak antibiotic action but when combined with other antibiotics may potentiate their antibacterial activity. Materials & methods: This study investigated in vitro antibacterial activity of diphenhydramine when used alone and in combination with levofloxacin against methicillin-resistant S. aureus and P. aeruginosa. Results: The combined antibacterial effec

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Billington, John K. "A New Product Development Partnership Model for Antibiotic Resistance." American Journal of Law & Medicine 42, no. 2-3 (2016): 487–523. http://dx.doi.org/10.1177/0098858816658277.

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Antibiotics have prevented countless deaths from common infections and have made possible many modern medical procedures. Over the past few decades, antibiotic-resistant bacteria have become a global threat, spreading between healthcare facilities and throughout communities worldwide at an alarming pace. Antibiotic overuse and misuse in humans, animals, and the environment accelerate resistance by selecting for bacteria with antibiotic-resistant traits, which then become predominant and infect others. Meanwhile, few antibiotics remain active against the most resistant bacteria. There is an urg

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Dey, Rajib, Kathakali De, Riya Mukherjee, Sreyan Ghosh, and Jayanta Haldar. "Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus." MedChemComm 10, no. 11 (2019): 1907–15. http://dx.doi.org/10.1039/c9md00329k.

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Ilktac, Mehmet, Mohammed Tamim Tarabishi, Pembe Ozbirtan, Canan Gulcan, and Gulden Celik. "A public awareness study about antibiotic consumption habits and antibacterial resistance in north-eastern region of Cyprus." Journal of Infection in Developing Countries 14, no. 05 (2020): 463–70. http://dx.doi.org/10.3855/jidc.11936.

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Introduction: Antibiotic resistance is a current global issue. Investigation of the level of knowledge of the public about antibiotics and antibiotic resistance is necessary to combat the antibiotic resistance problem. The aim of the present study was to evaluate the level of knowledge of the citizens of the north-eastern part of Cyprus on antibiotics and antibiotic resistance problem. Methodology: Randomly selected 701 adults were included in the study. A modified version of World Health Organization’s public awareness survey was used to assess the knowledge on antibiotics and the resis

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ROTARU, LUCIANA TEODORA, MARIUS NOVAC, and OANA NICOLAESCU. "ANTIBACTERIAL ACTIVITY OF FRESH ONION AND GARLIC JUICES." Journal of Science and Arts 20, no. 3 (2020): 705–12. http://dx.doi.org/10.46939/j.sci.arts-20.3-b02.

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Herbal extracts with antimicrobial potential represent an important research directive, in the current medical world, aiming to isolate active components, to develop new chemotherapeutic agents with applicability in the treatment or use as adjuvant therapy in infectious states. Antimicrobial properties of plants are conferred by their ability to synthesize certain secondary metabolites with relatively complex structures. The last century has been marked by sustained efforts to search for new natural compounds with antibacterial therapeutic properties, due to the gradual reduction in the number

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Barkus, Artūras, and Ingrida Lisauskienė. "Inappropriate habits of antibiotic use among medical specialists and students in Vilnius." Acta medica Lituanica 23, no. 2 (2016): 135–41. http://dx.doi.org/10.6001/actamedica.v23i2.3330.

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Introduction. The resistance to antibacterial drugs is an emerging worldwide problem. Numbers of inappropriate ways to use antibiotics contribute to this issue. Self-medication is one of them. This study seeks to find out how prevalent the self-medication with antibiotics, their storage at home and the inappropriate acquisition of antibacterial drugs are among medical specialists in Vilnius, Lithuania. Methods. A cross-sectional survey was conducted. To better identify the potential target groups, the respondents were classified according to their relation to medical care: physicians, other me

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Kroiča, Juta, Ingus Skadiņš, Ilze Salma, et al. "Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics / Bionoārdāmu Polimēru Saturošu Un Ar Antibiotiskajām Vielām Piesūcinātu Biomateriālu Antibakteriālās Efektivitātes Noteikšana." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 70, no. 4 (2016): 220–26. http://dx.doi.org/10.1515/prolas-2016-0035.

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Abstract Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency

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Wojciechowska, Monika, Marcin Równicki, Adam Mieczkowski, Joanna Miszkiewicz, and Joanna Trylska. "Antibacterial Peptide Nucleic Acids—Facts and Perspectives." Molecules 25, no. 3 (2020): 559. http://dx.doi.org/10.3390/molecules25030559.

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Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or screening compound libraries, but these strategies have not been successful in recent decades. An alternative approach could be to use gene-specific oligonucleotides, such as peptide nucleic acid (PNA) oligomers, th

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OHKI, HIDENORI, KOHJI KAWABATA, SHINYA OKUDA, TOSHIAKI KAMIMURA, and KAZUO SAKANE. "FK037, a new parenteral cephalosporin with a broad antibacterial spectrum: Synthesis and antibacterial activity." Journal of Antibiotics 46, no. 2 (1993): 359–61. http://dx.doi.org/10.7164/antibiotics.46.359.

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Laksmi Sulmartiwi, Prayogo, Rizky Aprilia Chrisanti,. "Efektivitas Perasan Asam Jawa (Tamarindus indica L) Terhadap Pertumbuhan Bakteri Aeromonas hydrophila Dengan Metode Difusi Kertas Cakram [Effectiveness Of Thamarin Juice (Tamarindus indica L) On Growth Of Bacteria Aeromonas hydrophila With Paper Disc Diffusion Method]." Jurnal Ilmiah Perikanan dan Kelautan 4, no. 2 (2019): 119. http://dx.doi.org/10.20473/jipk.v4i2.11560.

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Abstract Fish disease is one of the serious problems that faced by the farmers potentially to make high disadvantages as follows, mortality of fish and fish quality decrease, therefore economically will caused price decrease. Bacterial pathogens were one of the problems that were faced by fish farmers, which cause 90% of mortality. Diseases control caused by Aeromonas hydrophila in general using by antibiotics. Antibiotics are commonly used were tetracycline, oxolinic acid, erytromicin, streptomycin, and chloramphenicol. Using of antibiotics has shown good results, but on the other hand using

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Balemans, Wendy, Luc Vranckx, Nacer Lounis, et al. "Novel Antibiotics Targeting Respiratory ATP Synthesis in Gram-Positive Pathogenic Bacteria." Antimicrobial Agents and Chemotherapy 56, no. 8 (2012): 4131–39. http://dx.doi.org/10.1128/aac.00273-12.

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ABSTRACTEmergence of drug-resistant bacteria represents a high, unmet medical need, and discovery of new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been validated as an antibacterial target inMycobacterium tuberculosis, where its activity can be specifically blocked by the diarylquinoline TMC207. However, potency of TMC207 is restricted to mycobacteria with little or no effect on the growth of other Gram-positive or Gram-negative bacteria. Here, we identify diarylquinolines with activity against key Gram-positive pathogens, significantly extending the a

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Akbar, Noor, Ruqaiyyah Siddiqui, Mazhar Iqbal, and Naveed Ahmed Khan. "Antibacterial Activities of Selected Pure Compounds Isolated from Gut Bacteria of Animals Living in Polluted Environments." Antibiotics 9, no. 4 (2020): 190. http://dx.doi.org/10.3390/antibiotics9040190.

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Antibiotic resistance is a global threat to public health, further accelerated by the misuse of antibiotics in humans and animals. Our recent studies have shown that gut bacteria of animals living in polluted environments are a potential source of antibacterials. Gut bacteria of cockroaches, water monitor lizards and the turtle exhibited molecules such as curcumenol, docosanedioic acid, N-acyl-homoserine lactone, L-homotyrosine and Di-rhamnolipids. Using purified compounds, assays were performed to determine their antibacterial properties using serial dilution method, cytotoxic effects using l

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Almeida, Ray S., Priscilla R. Freitas, Ana Carolina J. Araújo, et al. "GC-MS Profile and Enhancement of Antibiotic Activity by the Essential Oil of Ocotea odorífera and Safrole: Inhibition of Staphylococcus aureus Efflux Pumps." Antibiotics 9, no. 5 (2020): 247. http://dx.doi.org/10.3390/antibiotics9050247.

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Considering the evidence that essential oils, as well as safrole, could modulate bacterial growth in different resistant strains, this study aims to characterize the phytochemical profile and evaluate the antibacterial and antibiotic-modulating properties of the essential oil Ocotea odorífera (EOOO) and safrole against efflux pump (EP)-carrying strains. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed by gas chromatography coupled to mass spectrometry (GC-MS). The antibacterial and antibiotic-modulating activities of the EOOO and safrole against resista

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Jubair, Najwan, Mogana Rajagopal, Sasikala Chinnappan, Norhayati Binti Abdullah, and Ayesha Fatima. "Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)." Evidence-Based Complementary and Alternative Medicine 2021 (August 16, 2021): 1–30. http://dx.doi.org/10.1155/2021/3663315.

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Microbial resistance has progressed rapidly and is becoming the leading cause of death globally. The spread of antibiotic-resistant microorganisms has been a significant threat to the successful therapy against microbial infections. Scientists have become more concerned about the possibility of a return to the pre-antibiotic era. Thus, searching for alternatives to fight microorganisms has become a necessity. Some bacteria are naturally resistant to antibiotics, while others acquire resistance mainly by the misuse of antibiotics and the emergence of new resistant variants through mutation. Sin

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Savage, Paul B., Chunhong Li, Uale Taotafa, Bangwei Ding, and Qunying Guan. "Antibacterial properties of cationic steroid antibiotics." FEMS Microbiology Letters 217, no. 1 (2002): 1–7. http://dx.doi.org/10.1111/j.1574-6968.2002.tb11448.x.

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Chander, Yogesh, Kuldip Kumar, Sagar M. Goyal, and Satish C. Gupta. "Antibacterial Activity of Soil-Bound Antibiotics." Journal of Environmental Quality 34, no. 6 (2005): 1952–57. http://dx.doi.org/10.2134/jeq2005.0017.

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Kotrange, Harshada, Agnieszka Najda, Aarti Bains, Robert Gruszecki, Prince Chawla, and Mansuri M. Tosif. "Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics." International Journal of Molecular Sciences 22, no. 17 (2021): 9596. http://dx.doi.org/10.3390/ijms22179596.

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In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioac

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