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Journal articles on the topic 'Antibiotic carrier'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Winkler, Heinz, and Peter Haiden. "Allograft Bone as Antibiotic Carrier." Journal of Bone and Joint Infection 2, no. 1 (2017): 52–62. http://dx.doi.org/10.7150/jbji.17466.

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Abstract. The treatment of chronic bone and joint infections is characterized by obstinate persistency of the causing microorganisms and resulting long term disability to patients, associated with remarkable costs for the health care system. Difficulties derive from biofilm formed on dead bone and eventual implants, with resistance against immunological defences and antimicrobial substances. Biofilm embedded bacteria require up to 1000 times the antibiotic concentration of planktonic bacteria for elimination. Systemic antibiotic treatment alone cannot provide the concentrations required and su

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Coraça-Huber, Débora C., Stephan J. M. Steixner, Stevo Najman, et al. "Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study." Antibiotics 11, no. 7 (2022): 969. http://dx.doi.org/10.3390/antibiotics11070969.

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Background: Antibiotics delivered from implanted bone substitute materials (BSM) can potentially be used to prevent acute infections and biofilm formation, providing high concentrations of antibiotics at the surgical site without systemic toxicity. In addition, BSM should allow osteoconductivity supporting bone healing without further surgery. Promising results have been achieved using lyophilized bone allografts mixed with antibiotics. Methods: In this study specially prepared human bone allografts were evaluated as an antibiotic carrier in vitro and in vivo. The efficacy of different antibio

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Kotrange, Harshada, Agnieszka Najda, Aarti Bains, Robert Gruszecki, Prince Chawla, and Mansuri M. Tosif. "Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics." International Journal of Molecular Sciences 22, no. 17 (2021): 9596. http://dx.doi.org/10.3390/ijms22179596.

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In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioac

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Smolle, Maria, Hana Murtezai, Tobias Niedrist, et al. "Vancomycin Elution Kinetics of Four Antibiotic Carriers Used in Orthopaedic Surgery: In Vitro Study Over 42 Days." Antibiotics 12, no. 11 (2023): 1636. http://dx.doi.org/10.3390/antibiotics12111636.

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This study aimed to analyse and compare the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice within a 42-day in vitro setting. Carriers A and D already contained vancomycin (1.1 g and 0.247 g), whereas carriers B and C were mixed with vancomycin according to the manufacturer’s recommendations (B: 0.83 g and C: 0.305 g). At nine time points, 50% (4.5 mL) of the elution sample was removed and substituted with the same amount of PBS. Probes were analysed with a kinetic microparticle immunoassay. Time-dependent changes in vancomycin c

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Ferguson, Jamie, Michael Diefenbeck, and Martin McNally. "Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections." Journal of Bone and Joint Infection 2, no. 1 (2017): 38–51. http://dx.doi.org/10.7150/jbji.17234.

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Abstract. Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous def

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Rasita, Yoeke Dewi, Kuntaman, and Kartuti Debora. "Description of Antibiotic Susceptibility Pattern Analysis on Methicillin-Susceptible Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Clothing Gene Panton-Valentine Leukocidin from Clinic Isolate." Journal of Computational and Theoretical Nanoscience 17, no. 7 (2020): 3085–91. http://dx.doi.org/10.1166/jctn.2020.9140.

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Staphylococcus aureus is the most common cause of health care acquired infection and has a high rate of morbidity and mortality. S. aureus has a number of virulent factors that facilitate these bacteria to adhesion to the tissues of the host, avoiding the body’s defense system, and damaging the host cell. PVL cytotoxin is one of the virulent factors that causes hypervirulent in S. aureus. The infections caused are varied, ranging from severe skin infections, peneumonia, and sepsis. To obtain a description of the antibiotic susceptibility pattern in Methicillin-sensitive Staphylococcus aureus (

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Niemczyk, Wojciech, Jacek Żurek, Stanisław Niemczyk, et al. "Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies." International Journal of Molecular Sciences 26, no. 5 (2025): 2140. https://doi.org/10.3390/ijms26052140.

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Platelet-rich fibrin (PRF) has emerged as a promising scaffold for drug delivery, particularly in the context of antimicrobial therapies. This systematic review evaluates the incorporation of antibiotics into PRF to determine its efficacy as a localized antimicrobial delivery system compared to plain PRF without antibiotics. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including 13 in vitro studies with a moderate risk of bias. Antibiotics were incorporated into PRF using different methodologies, incl

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Witsø, Eivind, Leif Persen, Kirsti Løseth, Pål Benum, and Kåre Bergh. "Cancellous bone as an antibiotic carrier." Acta Orthopaedica Scandinavica 71, no. 1 (2000): 80–84. http://dx.doi.org/10.1080/00016470052943955.

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Dzięcioł, M., W. Niżański, E. Stańczyk, R. Kozdrowski, L. Najder-Kozdrowska, and J. Twardoń. "The influence of antibiotic treatment of bitches in oestrus on their attractiveness to males during mating." Polish Journal of Veterinary Sciences 16, no. 3 (2013): 509–16. http://dx.doi.org/10.2478/pjvs-2013-0071.

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Abstract The aim of this study was to evaluate the influence of the antibiotic treatment, including the mode of drugs administration, on bitches’ attractiveness to the stud dogs during mating. Moreover, we tried to estimate the possibility of aversive effect of the drug vehicle on the male behavior. In experiment I, four bitches in oestrus without antibiotic treatment (group A), four bitches treated with intravaginal antibiotic (group B) and four bitches treated with intramuscular antibiotic (group C) were presented to four stud dogs. In experiment II, bitches in oestrus (n=5) were presented t

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LACLAIR, J., T. FOLEY, T. SCHEGG, C. REGAN, and M. BURKART. "Manipulation of Carrier Proteins in Antibiotic Biosynthesis." Chemistry & Biology 11, no. 2 (2004): 195–201. http://dx.doi.org/10.1016/s1074-5521(04)00032-8.

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Marchianò, Verdiana, María Matos, Esther Serrano-Pertierra, Gemma Gutiérrez, and M. C. Blanco-López. "Vesicles as antibiotic carrier: State of art." International Journal of Pharmaceutics 585 (July 2020): 119478. http://dx.doi.org/10.1016/j.ijpharm.2020.119478.

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La Clair, James J., Timothy L. Foley, Tracy R. Schegg, Conor M. Regan, and Michael D. Burkart. "Manipulation of Carrier Proteins in Antibiotic Biosynthesis." Chemistry & Biology 11, no. 2 (2004): 195–201. http://dx.doi.org/10.1016/j.chembiol.2004.02.010.

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Karr, Jeffrey C., Joseph Lauretta, and Georgia Keriazes. "In Vitro Antimicrobial Activity of Calcium Sulfate and Hydroxyapatite (Cerament Bone Void Filler) Discs Using Heat-Sensitive and Non–Heat-sensitive Antibiotics Against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa." Journal of the American Podiatric Medical Association 101, no. 2 (2011): 146–52. http://dx.doi.org/10.7547/1010146.

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Background: Several absorbable and nonabsorbable antibiotic carrier systems are available in the adjunctive surgical management of osteomyelitis of the foot, ankle, and lower leg. These carrier systems have significant limitations regarding which antibiotics can be successfully incorporated into the carrier vehicle. The calcium sulfate and hydroxyapatite Cerament Bone Void Filler is a biocompatible, absorbable ceramic bone void filler that can successfully deliver multiple heat-stable and heat-unstable antibiotics that have not been generally used before with antibiotic beads in treating muscu

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Anagnostakos, Konstantinos, and Katrin Schröder. "Antibiotic-Impregnated Bone Grafts in Orthopaedic and Trauma Surgery: A Systematic Review of the Literature." International Journal of Biomaterials 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/538061.

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There exist several options for local antibiotic therapy in orthopaedic and trauma surgery. Over the past years, the use of antibiotic-impregnated bone grafts (AIBGs) has become a popular procedure in the treatment of bone and joint infections. A major advantage of AIBGs involves the possibility of impregnation of various antibiotics depending on the sensitivity profile of the causative organism, whereas an additional surgery with removal of the antibiotic carrier is not necessary, as in the use of antibiotic-loaded bone cement. However, generalized conclusions cannot be clearly drawn from the

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Steadman, William, Paul R. Chapman, Michael Schuetz, Beat Schmutz, Andrej Trampuz, and Kevin Tetsworth. "Local Antibiotic Delivery Options in Prosthetic Joint Infection." Antibiotics 12, no. 4 (2023): 752. http://dx.doi.org/10.3390/antibiotics12040752.

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Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally. Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes and enhance biofilm eradication. These antibiotics can be delivered using an intra-articular catheter or combined with a carrier substance to enhance pharmacokinetic properties. Carrier options include non-resorbable polymethylmethacrylate (PMMA) bone cement and resorbable calcium sulphate, hydroxyapatite, bioactive glass, and hydrogels. PMMA allows for creation of structural spacers used in multi-sta

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Rotman, Stijn G., Thomas F. Moriarty, Benjamin Nottelet, Dirk W. Grijpma, David Eglin та Olivier Guillaume. "Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers". Pharmaceutics 12, № 9 (2020): 885. http://dx.doi.org/10.3390/pharmaceutics12090885.

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Bone infection is a feared complication for patients with surgically fixed bone fractures and local antibiotic delivery is important in prophylaxis and treatment of these infections. Recent studies indicated that Staphylococcus aureus can penetrate bone tissue through micron-sized canaliculi and evade systemic and currently available local antibiotic treatments. Targeting bacteria within the bone requires highly efficient delivery of antimicrobials to the infected bone tissue. In this work, a biodegradable microsphere carrier loaded with antibiotics and with specific affinity to bone mineral w

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Ahmed Azeem, Muhammad. "Antibiotic Resistance Profiling of Pseudomonas Species Isolated from Cloacal Swab of Domestic Pigeons." Lahore Garrison University Journal of Life Sciences 5, no. 3 (2021): 155–63. http://dx.doi.org/10.54692/lgujls.2021.0503173.

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Antibiotics are used to treat a number of bacterial infections. However, overuse or misuse of antibiotics has raised serious concerns against antibioticresistance amongst bacteria. Hence, antibiotics are becoming inefficient in treating bacterial infections leading to an increase in mortality rate worldwide. The domestic animals especially birds are a major source of transmission of antibiotic resistant bacteria in human through excrement and cause bacterial diseases in human. The aim of the present study was to assess the efficacy of different antibiotics prior to their prescription as a meas

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Eriksen, N. H. Riewerts, F. Espersen, V. Thamdrup Rosdahl, and K. Jensen. "Carriage ofStaphylococcus aureusamong 104 healthy persons during a 19-month period." Epidemiology and Infection 115, no. 1 (1995): 51–60. http://dx.doi.org/10.1017/s0950268800058118.

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SummaryThe present study was undertaken to investigate the frequency of the nasal carrier rate ofStaphylococcus aureus. The investigation was performed on 104 healthy persons. The total number of swabs performed was 1498 and this resulted in isolation of 522S. aureusstrains. All strains have been identified, tested for antibiotic susceptibility, and phage-typed. The carrier-index (number of positive swabs/number of total swabs for each individual person) was compared with different sampling and culturing methods, phage type, age, and resistance to antibiotics. There was statistical difference

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Coraça-Huber, Débora C., Christoph G. Ammann, Michael Nogler, et al. "Lyophilized allogeneic bone tissue as an antibiotic carrier." Cell and Tissue Banking 17, no. 4 (2016): 629–42. http://dx.doi.org/10.1007/s10561-016-9582-5.

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Zhang, Lu, Ying Huang, Yang Zhou, Timothy Buckley, and Hua H. Wang. "Antibiotic Administration Routes Significantly Influence the Levels of Antibiotic Resistance in Gut Microbiota." Antimicrobial Agents and Chemotherapy 57, no. 8 (2013): 3659–66. http://dx.doi.org/10.1128/aac.00670-13.

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ABSTRACTThis study examined the impact of oral exposure to antibiotic-resistant bacteria and antibiotic administration methods on antibiotic resistance (AR) gene pools and the profile of resistant bacteria in host gastrointestinal (GI) tracts using C57BL/6J mice with natural gut microbiota. Mice inoculated with a mixture oftet(M)-carryingEnterococcusspp. orblaCMY-2-carryingEscherichia coliwere treated with different doses of tetracycline hydrochloride (Tet) or ampicillin sodium (Amp) and delivered via either feed or intravenous (i.v.) injection. Quantitative PCR assessment of mouse fecal sampl

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Ngo Thu Huong, Hoang Thi Huyen, and Truong Quoc Phong. "Conjugation of tetracycline with carrier proteins and production of its polyclonal antibody for the development of rapid test." Vietnam Journal of Science and Technology 62, no. 1 (2024): 23–34. http://dx.doi.org/10.15625/2525-2518/17325.

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Tetracycline (TC) is a broad-spectrum antibiotic used in the treatment of several infectious diseases. The excessive use of tetracycline antibiotics, especially tetracyclines in livestock, has raised concerns about residues of tetracycline antibiotics in food that may affect consumers' health. It is necessary to develop a rapid test strip for detecting tetracycline antibiotic residues in food and animal feed. This paper presents the suitable conditions for the conjugation of tetracycline to BSA or KLH: molar ratio of TC:BSA/KLH was 25:1, formaldehyde concentration of 5 %, temperature of 4oC an

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Flores, Michael J., Kelsey E. Brown, Saam Morshed, and David W. Shearer. "Evidence for Local Antibiotics in the Prevention of Infection in Orthopaedic Trauma." Journal of Clinical Medicine 11, no. 24 (2022): 7461. http://dx.doi.org/10.3390/jcm11247461.

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Prevention of fracture-related infection (FRI) remains a substantial challenge in orthopaedic trauma care. There is evolving evidence to support the use of local antibiotics for both the prevention and treatment of musculoskeletal infection. Local antibiotics can achieve higher local tissue concentrations with a lower risk of systemic complications compared to intravenously administered antibiotics. These antibiotics may be administered in powder or liquid form without carrier, or if sustained release is desired, using a carrier. Polymethylmethacrylate (PMMA), ceramics, and hydrogels are examp

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Su, Wen-Yu, Yu-Chun Chen, and Feng-Huei Lin. "A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/801374.

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Osteomyelitis therapy is a long-term and inconvenient procedure for a patient. Antibiotic-loaded bone cements are both a complementary and alternative treatment option to intravenous antibiotic therapy for the treatment of osteomyelitis. In the current study, the biphasic calcium phosphate cement (CPC), calledα-TCP/HAP (α-tricalcium phosphate/hydroxyapatite) biphasic cement, was prepared as an antibiotics carrier for osteomyelitis. The developed biphasic cement with a microstructure ofα-TCP surrounding the HAP has a fast setting time which will fulfill the clinical demand. The X-ray diffractio

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Colding-Rasmussen, Thomas, Peter Horstmann, Michael Mørk Petersen, and Werner Hettwer. "Antibiotic Elution Characteristics and Pharmacokinetics of Gentamicin and Vancomycin from a Mineral Antibiotic Carrier: An in vivo Evaluation of 32 Clinical Cases." Journal of Bone and Joint Infection 3, no. 4 (2018): 234–40. http://dx.doi.org/10.7150/jbji.26301.

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Abstract. Introduction: Locally implanted antibiotic-eluting carriers may be a valuable adjuvant to the management of prosthetic joint infections. Aim: to assess local and plasma antibiotic concentrations as well as cumulative antibiotic urine excretion associated with clinical use of a gentamicin - or vancomycin-loaded mineral composite antibiotic carrier.Methods: 32 patients (male/female=19/13, mean age=56; 21-82 years) were prospectively followed after implantation of gentamicin (n=11), vancomycin (n=15), or a combination (n=7), using an antibiotic carrier (CERAMENT™|G or CERAMENT™|V, mean

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Reinisch, Katharina, Michel Schläppi, Christoph Meier, and Peter Wahl. "Local antibiotic treatment with calcium sulfate as carrier material improves the outcome of debridement, antibiotics, and implant retention procedures for periprosthetic joint infections after hip arthroplasty – a retrospective study." Journal of Bone and Joint Infection 7, no. 1 (2022): 11–21. http://dx.doi.org/10.5194/jbji-7-11-2022.

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Abstract. Purpose: Debridement, antibiotics, and implant retention (DAIR) is an established treatment modality in periprosthetic joint infections (PJIs), but success rates vary. This study compared the success of DAIR for PJIs after a total hip arthroplasty (THA), with or without local antibiotic delivery with CaSO4 as the carrier material. Methods: A retrospective review of DAIR for PJIs after THA performed between 2010 and 2018, including 41 patients is conducted. A total of 27 patients were treated by DAIR with local antibiotics with CaSO4 as the carrier material, and 14 patients were treat

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Ibrahim, Nassereldin, Darlene Nesbitt, Qian (Tracy) Guo, et al. "Improved Viability of Spray-Dried Pantoea agglomerans for Phage-Carrier Mediated Control of Fire Blight." Viruses 16, no. 2 (2024): 257. http://dx.doi.org/10.3390/v16020257.

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Fire blight, caused by Erwinia amylovora, is a devastating bacterial disease that threatens apple and pear production. It is mainly controlled by using antibiotics, such as streptomycin. Due to development of E. amylovora resistant strains and the excessive agricultural use of antibiotics, there is an increased awareness of the possibility of antibiotic resistance gene transfer to other microbes. Urgent development of biocontrol agents (BCAs) is needed that can be incorporated into integrated pest management programs as antibiotic alternatives. A novel phage-carrier system (PCS) that combines

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Suwanprateeb, J., F. Thammarakcharoen, P. Phanphiriya, W. Chokevivat, W. Suvannapruk, and B. Chernchujit. "PREPARATION AND CHARACTERIZATIONS OF ANTIBIOTIC IMPREGNATED MICROPOROUS NANO-HYDROXYAPATITE FOR OSTEOMYELITIS TREATMENT." Biomedical Engineering: Applications, Basis and Communications 26, no. 03 (2014): 1450041. http://dx.doi.org/10.4015/s1016237214500410.

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In this study, preparation and characterization of antibiotic-impregnated microporous nano-hydroxyapatite (HA) aiming to function as both antibiotic carrier and bone graft for osteomyelitis treatment were carried out. Microporous nano-hydroxyapatite was prepared by low temperature phosphorization of three-dimensional printed calcium sulfate sample and was impregnated by three types of antibiotics including vancomycin, fosfomycin and gentamicin. Materials properties and antibacterial performance including phase composition, microstructure, degradability, total drug loading, antibacterial activi

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Wahl, Peter, Karolin Rönn, Marc Bohner, et al. "In vitro study of new combinations for local antibiotic therapy with calcium sulphate - Near constant release of ceftriaxone offers new treatment options." Journal of Bone and Joint Infection 3, no. 4 (2018): 212–21. http://dx.doi.org/10.7150/jbji.26218.

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Abstract. Introduction: Local application of antibiotics provides high concentrations at the site of interest, with minimal systemic toxicity. Carrier materials might help manage dead space. Calcium sulphate (CaSO4) has a dissolution time that only slightly exceeds the usually recommended duration of systemic antibiotic treatments. This in vitro study evaluates compatibility, release kinetics and antibacterial activity of new combinations of antibiotics with CaSO4 as carrier material.Methods: CaSO4 pellets added with 8% w/w antibiotic powder were exposed once in phosphate-buffered saline (PBS)

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Engin, Ayse Basak, and Atilla Engin. "Nanoantibiotics: A Novel Rational Approach to Antibiotic Resistant Infections." Current Drug Metabolism 20, no. 9 (2019): 720–41. http://dx.doi.org/10.2174/1389200220666190806142835.

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Background: The main drawbacks for using conventional antimicrobial agents are the development of multiple drug resistance due to the use of high concentrations of antibiotics for extended periods. This vicious cycle often generates complications of persistent infections, and intolerable antibiotic toxicity. The problem is that while all new discovered antimicrobials are effective and promising, they remain as only short-term solutions to the overall challenge of drug-resistant bacteria. Objective: Recently, nanoantibiotics (nAbts) have been of tremendous interest in overcoming the drug resist

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Bormann, Nicole, Aysha Schmock, Anja Hanke, et al. "Analysis of the Ability of Different Allografts to Act as Carrier Grafts for Local Drug Delivery." Journal of Functional Biomaterials 14, no. 6 (2023): 305. http://dx.doi.org/10.3390/jfb14060305.

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Bone defects and infections pose significant challenges for treatment, requiring a comprehensive approach for prevention and treatment. Thus, this study sought to evaluate the efficacy of various bone allografts in the absorption and release of antibiotics. A specially designed high-absorbency, high-surface-area carrier graft composed of human demineralized cortical fibers and granulated cancellous bone (fibrous graft) was compared to different human bone allograft types. The groups tested here were three fibrous grafts with rehydration rates of 2.7, 4, and 8 mL/g (F(2.7), F(4), and F(8)); dem

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Wu, Lei, Xinqiang Xie, Ying Li, et al. "Metagenomics-Based Analysis of the Age-Related Cumulative Effect of Antibiotic Resistance Genes in Gut Microbiota." Antibiotics 10, no. 8 (2021): 1006. http://dx.doi.org/10.3390/antibiotics10081006.

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Antibiotic resistance in bacteria has become a major global health problem. One of the main reservoirs of antibiotic resistance genes is the human gut microbiota. To characterise these genes, a metagenomic approach was used. In this study, a comprehensive antibiotic resistome catalog was established using fecal samples from 246 healthy individuals from world’s longevity township in Jiaoling, China. In total, 606 antibiotic resistance genes were detected. Our results indicated that antibiotic resistance genes in the human gut microbiota accumulate and become more complex with age as older group

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Bischoff, Werner E., Michelle L. Wallis, Keith B. Tucker, Beth A. Reboussin, and Robert J. Sherertz. "Staphylococcus aureusNasal Carriage in a Student Community Prevalence, Clonal Relationships, and Risk Factors." Infection Control & Hospital Epidemiology 25, no. 6 (2004): 485–91. http://dx.doi.org/10.1086/502427.

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AbstractObjective:To evaluate the prevalence and risk factors of nasalStaphylococcus aureus(SA) in the community.Design:Cross-sectional study.Setting:Wake Forest University, Winston-Salem, North Carolina.Participants:Four hundred fifty students were screened for nasal SA carriage during the fall of 2000, 2001, and 2002.Methods:Students were screened by nose swabs. A self-administered questionnaire collected information on demographics and medical history. Antibiotic testing and PFGE were performed on isolates. Risk factors were determined by logistic regression analysis.Results:Of 450 voluntee

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Cheng, Xiaojie, Xiaojun Qin, Runxue Zhao, et al. "Construction of Co-Modified MXene/PES Catalytic Membrane for Effective Separation and Degradation of Tetracycline Antibiotics in Aqueous Solutions." Molecules 29, no. 21 (2024): 4995. http://dx.doi.org/10.3390/molecules29214995.

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The application of antibiotics has advanced modern medicine significantly. However, the abuse and discharge of antibiotics have led to substantial antibiotic residues in water, posing great harm to natural organisms and humans. To address the problem of antibiotic degradation, this study developed a novel catalytic membrane by depositing Co catalysts onto MXene nanosheets and fabricating the polyethersulfone composite (Co@MXene/PES) using vacuum-assisted self-assembly. The dual role of MXene as both a carrier for Co atoms and an enhancer of interlayer spacing led to improved flux and catalytic

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Yao, Jiangwei, Robert A. Carter, Grégoire Vuagniaux, Maryse Barbier, Jason W. Rosch, and Charles O. Rock. "A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome." Antimicrobial Agents and Chemotherapy 60, no. 7 (2016): 4264–73. http://dx.doi.org/10.1128/aac.00535-16.

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ABSTRACTBroad-spectrum antibiotic therapy decimates the gut microbiome, resulting in a variety of negative health consequences. Debio 1452 is a staphylococcus-selective enoyl-acyl carrier protein reductase (FabI) inhibitor under clinical development and was used to determine whether treatment with pathogen-selective antibiotics would minimize disturbance to the microbiome. The effect of oral Debio 1452 on the microbiota of mice was compared to the effects of four commonly used broad-spectrum oral antibiotics. During the 10 days of oral Debio 1452 treatment, there was minimal disturbance to the

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Sebastian, Sujeesh, Felix Tandberg, Yang Liu, et al. "Extended local release and improved bacterial eradication by adding rifampicin to a biphasic ceramic carrier containing gentamicin or vancomycin." Bone & Joint Research 11, no. 11 (2022): 787–802. http://dx.doi.org/10.1302/2046-3758.1111.bjr-2022-0101.r1.

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Aims There is a lack of biomaterial-based carriers for the local delivery of rifampicin (RIF), one of the cornerstone second defence antibiotics for bone infections. RIF is also known for causing rapid development of antibiotic resistance when given as monotherapy. This in vitro study evaluated a clinically used biphasic calcium sulphate/hydroxyapatite (CaS/HA) biomaterial as a carrier for dual delivery of RIF with vancomycin (VAN) or gentamicin (GEN). Methods The CaS/HA composites containing RIF/GEN/VAN, either alone or in combination, were first prepared and their injectability, setting time

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Cieslak, Erin, James P. Mack, and Albert Rojtman. "ESSENTIAL OILS AND METHYLGLYOXAL: A POSSIBLE ALTERNATIVE TREATMENT FOR ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 107. http://dx.doi.org/10.22159/ijpps.2016.v8i9.12242.

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<p><strong>Objective: </strong>Essential oils are of significant interest in today’s world of healthcare because these compounds have a variety of medicinal properties. In this study, we evaluated the <em>in vitro</em> antibiotic role of essential oils as a possible alternative treatment in combatting Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA).</p><p><strong>Methods: </strong>In conjunction with carrier oils, three essential oils (cassia, cinnamon bark, and thyme), as well as methylglyoxal were tested on MRSA us

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Phanphiriya, P., Faungchat Thammarakcharoen, Watchara Chokevivat, and Jintamai Suwanprateeb. "Antimicrobial Performance and Cytotoxicity of Antibiotics Impregnated Hydroxyapatite for Osteomyelitis Treatment." Advanced Materials Research 506 (April 2012): 513–16. http://dx.doi.org/10.4028/www.scientific.net/amr.506.513.

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Localized antibiotic beads are often used for treating patients with osteomyelitis or infections of the bone by providing local, sustained and high concentrations of antimicrobial agents to the area of infection, without systemically exposing an individual to antibiotic levels that could result in numerous toxic side effects. In this study, antibiotic impregnated hydroxyapatite spheres were prepared aiming for a functional device of drug carrier and bone graft. Three types of antibiotics were employed including gentamicin, vancomycin and fosfomycin. Antimicrobial susceptibility of antibiotic i

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Alduina, Rosa, Delia Gambino, Alessandro Presentato, et al. "Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea?" Antibiotics 9, no. 3 (2020): 116. http://dx.doi.org/10.3390/antibiotics9030116.

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Sea turtles can be considered a sentinel species for monitoring the health of marine ecosystems, acting, at the same time, as a carrier of microorganisms. Indeed, sea turtles can acquire the microbiota from their reproductive sites and feeding, contributing to the diffusion of antibiotic-resistant strains to uncontaminated environments. This study aims to unveil the presence of antibiotic-resistant bacteria in (i) loggerhead sea turtles stranded along the coast of Sicily (Mediterranean Sea), (ii) unhatched and/or hatched eggs, (iii) sand from the turtles’ nest and (iv) seawater. Forty-four bac

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Cho, B. O., H. H. Gim, Y. C. Lee, et al. "The effect of fibrin glue as a local antibiotic carrier." International Journal of Oral and Maxillofacial Surgery 26 (January 1997): 251–52. http://dx.doi.org/10.1016/s0901-5027(97)81585-8.

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Brieke, Clara, Veronika Kratzig, Kristina Haslinger, Andreas Winkler, and Max J. Cryle. "Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics." Organic & Biomolecular Chemistry 13, no. 7 (2015): 2012–21. http://dx.doi.org/10.1039/c4ob02452d.

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Troiano, E., P. Giacomo, M. Di Meglio, et al. "STIMULAN® IN ORTHOPAEDIC SURGERY: TECHNIQUE AND INDICATIONS FOR USE." Orthopaedic Proceedings 105-B, SUPP_7 (2023): 95. http://dx.doi.org/10.1302/1358-992x.2023.7.095.

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Infections represent a devastating complication in orthopedic and traumatological surgery, with high rates of morbidity and mortality. An early intervention is essential, and it includes a radical surgical approach supported by targeted intravenous antimicrobial therapy. The availability of parenteral antibiotics at the site of infection is usually poor, so it is crucial to maximize local antibiotic concentration using local carriers. Our work aims to describe the uses of one of these systems, Stimulan®, for the management and prevention of infections at our Institution.Analysing the reported

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Glehr, Mathias, Maria Smolle, Hana Murtezai, et al. "VANCOMYCIN ELUTION KINETICS FROM ANTIBIOTIC AUGMENTED ALLOGRAFT AND RESORBABLE SYNTHETIC BONE FILLER SUPERIOR TO ANTIBIOTIC AUGMENTED BONE CEMENT: AN IN VITRO STUDY OVER 42 DAYS." Orthopaedic Proceedings 106-B, SUPP_19 (2024): 87. http://dx.doi.org/10.1302/1358-992x.2024.19.087.

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AbstractBackgroundThe aim of the present experimental study was to analyse vancomycin elution kinetics of nine bone fillers used in orthopaedic and trauma surgery over 42 consecutive days.MethodsTwo allograft bone chips (carriers 1 and 2), a calcium-sulfate matrix (carrier 3), a hydroxyapatite/calcium-sulphate composite (carrier 4), four bone cements (carriers 5-8) and a pure tricalcium phosphate matrix (carrier 9), either already contained vancomycin, or were mixed with it following manufacturer's recommendations. Over 42 days, half of elution medium was substituted by the same amount of PBS

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S B, Nagansurkar, Hemant K. S. Yadav, and Raizaday Abhay. "Current Update on Electrospun Nanofiber Mats as a Wound Healing Drug Carrier." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 523–30. http://dx.doi.org/10.25258/ijddt.14.1.72.

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Electrospun nanofiber mats are being researched as attractive wound-healing drug carriers owing to their exclusive features, large active surface area, interlinked porosity, and customizable drug release kinetics. These mats may be infused with antibiotics, growth hormones, or stem cells to hasten the process of healing and lessen the likelihood of problems. Controlled and sustained medication delivery is the key payback of electrospun nanofiber mats. Electrospun nanofiber mats promote wound healing in part because of the favorable milieu they provide cell adhesion and proliferation of the aff

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De Meo, Daniele, Paolo Martini, Maria Francesca Pennarola, et al. "Hydrogel Coating versus Calcium Sulphate Beads as a Local Antibiotic Carrier for Debridement Procedures in Acute Periprosthetic Joint Infection: A Preliminary Study." Gels 9, no. 9 (2023): 758. http://dx.doi.org/10.3390/gels9090758.

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Periprosthetic joint infections (PJI) are among the most difficult complications to treat in orthopaedic surgery. Debridement, antibiotics, and implant retention (DAIR) represent an efficient strategy for acute PJI, especially when resorbable local antibiotic carriers and coatings are used. The aim of this pilot study was to evaluate the difference between using antibiotic-loaded hydrogel (ALH) and calcium sulphate (CS) beads in the DAIR procedure. We analysed 16 patients who had been treated since 2018 for acute PJI, namely eight patients with knee PJI (50%), seven with hip PJI (43.7%), and o

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Six, David A., Yanqiu Yuan, Jennifer A. Leeds та Timothy C. Meredith. "Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility". Antimicrobial Agents and Chemotherapy 58, № 1 (2013): 153–61. http://dx.doi.org/10.1128/aac.01804-13.

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ABSTRACTThe β-acetoacetyl-acyl carrier protein synthase FabY is a key enzyme in the initiation of fatty acid biosynthesis inPseudomonas aeruginosa. Deletion offabYresults in an increased susceptibility ofP. aeruginosain vitroto a number of antibiotics, including vancomycin and cephalosporins. Because antibiotic susceptibility can be influenced by changes in membrane lipid composition, we determined the total fatty acid profile of the ΔfabYmutant, which suggested alterations in the lipid A region of the lipopolysaccharide. The majority of lipid A species in the ΔfabYmutant lacked a single secon

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Labbaf, Sheyda, Harry Horsley, Ming-Wei Chang, et al. "An encapsulated drug delivery system for recalcitrant urinary tract infection." Journal of The Royal Society Interface 10, no. 89 (2013): 20130747. http://dx.doi.org/10.1098/rsif.2013.0747.

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One of the hallmarks of urinary tract infection, a serious global disease, is its tendency to recur. Uropathogenic bacteria can invade cells lining the bladder, where they form longer-term intracellular reservoirs shielded from antibiotics, re-emerging at a later date to initiate flare-ups. In these cases, only lengthy systemic antibiotic treatment can eradicate all the reservoirs. Yet, long courses of antibiotics are not ideal, as they can lead to side effects and an increase in antibiotic resistance. Moreover, most antibiotics lose some potency by the time they reach the bladder, and many ca

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Sebastian, S., M. Collin, Y. Liu, D. Raina, M. Tägil, and L. Lidgren. "ENHANCED STAPHYLOCOCCUS AUREUS ANTIBIOFILM ACTIVITY WITHOUT RESISTANCE DEVELOPMENT BY ADDING RIFAMPICIN TO A BIPHASIC CERAMIC CARRIER CONTAINING GENTAMICIN OR VANCOMYCIN." Orthopaedic Proceedings 105-B, SUPP_8 (2023): 66. http://dx.doi.org/10.1302/1358-992x.2023.8.066.

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There is a lack of carriers for the local delivery of rifampicin (RIF), one of the cornerstone second defence antibiotic for Staphylococcus aureus deep bone infections (DBIs). RIF is also associated with systemic side effects, and known for causing rapid development of antibiotic resistance when given as monotherapy. We evaluated a clinically usedbi-phasic calcium sulphate/hydroxyapatite (CaS/HA) biomaterial as a carrier for dual delivery of RIF with vancomycin (VAN) or gentamicin (GEN). It was hypothesized that this combined approach could provide improved biofilm eradication and prevent the

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Müller, Marik M., Ruslan Nedielkov, and Katja M. Arndt. "Strategies for Enzymatic Inactivation of the Veterinary Antibiotic Florfenicol." Antibiotics 11, no. 4 (2022): 443. http://dx.doi.org/10.3390/antibiotics11040443.

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Large quantities of the antibiotic florfenicol are used in animal farming and aquaculture, contaminating the ecosystem with antibiotic residues and promoting antimicrobial resistance, ultimately leading to untreatable multidrug-resistant pathogens. Florfenicol-resistant bacteria often activate export mechanisms that result in resistance to various structurally unrelated antibiotics. We devised novel strategies for the enzymatic inactivation of florfenicol in different media, such as saltwater or milk. Using a combinatorial approach and selection, we optimized a hydrolase (EstDL136) for florfen

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Zlotnikov, Igor D., Maria P. Davydova, Milan R. Danilov, Sergey S. Krylov, Natalya G. Belogurova, and Elena V. Kudryashova. "Covalent Conjugates of Allylbenzenes and Terpenoids as Antibiotics Enhancers with the Function of Prolonged Action." Pharmaceuticals 16, no. 8 (2023): 1102. http://dx.doi.org/10.3390/ph16081102.

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The drug resistance of pathogenic bacteria is often due efflux pumps—specific proteins that remove foreign compounds from bacterial cells. To overcome drug resistance, adjuvants are often used that can inhibit efflux pumps or other systems that ensure the resistance of bacteria to the action of antibiotics. We assumed that a new level of effectiveness with the use of an antibiotic + an adjuvant pair could be achieved by their joint delivery into the pathogen. To test this hypothesis, we constructed a series of molecular carriers based on poly-(olygo-, dendry)mers based on cyclodextrin-grafted

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Das, Manik, Partha Sakha Ghosh, and Kuntal Manna. "A Review on Platensimycin: A Selective FabF Inhibitor." International Journal of Medicinal Chemistry 2016 (January 28, 2016): 1–16. http://dx.doi.org/10.1155/2016/9706753.

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Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from Streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. So, isolation, retrosynthetic analysis, synthesis of platen

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