Academic literature on the topic 'Antibiotic effects on cochlea'

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Journal articles on the topic "Antibiotic effects on cochlea"

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Moore, David R., Nina J. Rogers, and Stephen J. O'Leary. "Loss of Cochlear Nucleus Neurons following Aminoglycoside Antibiotics or Cochlear Removal." Annals of Otology, Rhinology & Laryngology 107, no. 4 (1998): 337–43. http://dx.doi.org/10.1177/000348949810700413.

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This study compared the effects of aminoglycoside ototoxicity and surgical ablation of the cochlea in infancy on the survival of neurons in the rat cochlear nucleus (CN). Ototoxicity was induced by a single, systemic dose of gentamicin sulfate and furosemide on postnatal day 6 (P6), P7, or P10, and assessed by the elevation of auditory brain stem response thresholds, as described in a companion paper. Unilateral cochlear removals were performed under Saffan anesthesia on P6, P9, and P12. Rats were painlessly sacrificed in adulthood, and the formalin-perfused brains and cochleas were embedded i
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Meli, Damian N., Roney S. Coimbra, Dominik G. Erhart, et al. "Doxycycline Reduces Mortality and Injury to the Brain and Cochlea in Experimental Pneumococcal Meningitis." Infection and Immunity 74, no. 7 (2006): 3890–96. http://dx.doi.org/10.1128/iai.01949-05.

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ABSTRACT Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis. Doxycycline is a clinically used antibiotic with anti-inflammatory effects that lead to reduced cytokine release and the inhibition of MMPs. Here, doxycycline inhibited TACE with a 50% inhibitory
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Xuan, Weijun, Mingmin Dong, and Minsheng Dong. "Effects of Compound Injection of Pyrola Rotundifolia L and Astragalus Membranaceus Bge on Experimental Guinea Pigs' Gentamicin Ototoxicity." Annals of Otology, Rhinology & Laryngology 104, no. 5 (1995): 374–80. http://dx.doi.org/10.1177/000348949510400507.

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In attempting to find drugs effective in preventing and remedying ototoxic injury caused by aminoglycoside antibiotics, we relied on the theory that the induction of ototoxic injury by aminoglycoside antibiotics is related to a decrease of cyclic adenosine monophosphate and RNA content in the cochlea or a dysfunction of the kidney. We selected Pyrola rotundifolia L and Astragalus membranaceus Bge from traditional Chinese herbal medicine, made a compound injection of them, and observed the effect on the pattern of gentamicin ototoxicity in guinea pigs. By electrocochleography and morphology by
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Lee, Sun, Hyun Ju, Jin Choi, Yeji Ahn, Suhun Lee, and Young Seo. "Circulating Serum miRNA-205 as a Diagnostic Biomarker for Ototoxicity in Mice Treated with Aminoglycoside Antibiotics." International Journal of Molecular Sciences 19, no. 9 (2018): 2836. http://dx.doi.org/10.3390/ijms19092836.

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Background: To confirm levels and detection timing of circulating microRNAs (miRNAs) in the serum of a mouse model for diagnosis of ototoxicity, circulating miR-205 in the serum was evaluated to reflect damages in the cochlear microstructure and compared to a kidney injury model. Method: A microarray for miRNAs in the serum was performed to assess the ototoxic effects of kanamycin-furosemide. Changes in the levels for the selected miRNAs (miR-205, miR-183, and miR-103) were compared in the serum and microstructures of the cochlea (stria vascularis, organ of Corti, and modiolus) between the oto
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Huseynov, N. M., V. R. Fisenko, and P. R. Aslanov. "INFLUENCE OF OTOTOXIC PHARMACEUTICALS ON BIOELECTRIC RESPONSES IN CEREBRAL CORTEX AND COCHLEA." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 2 (2020): 124–28. http://dx.doi.org/10.31718/2077-1096.20.2.124.

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The article describes the results of the experiment aimed to find out the nature of changes in the excitability of the auditory cortex during prolonged taking of antibiotics, aminoglycosides, diuretics and salicylates. Methodology. The series of experiments was carried out on cats of both sexes weighing 3-3.5 kg, in natural behaviour. Rectangular threshold (1.5-3 V) and supra-threshold (5-7 V) electrical impulses lasting 0.1 ms were applied to the TCR fibres, using single and paired (interstimular intervals of 20-500ms) stimulation of the TCR fibres. As a source of irritating impulses, a multi
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Kim, Ye-Ri, Tae-Jun Kwon, Un-Kyung Kim, In-Kyu Lee, Kyu-Yup Lee, and Jeong-In Baek. "Fursultiamine Prevents Drug-Induced Ototoxicity by Reducing Accumulation of Reactive Oxygen Species in Mouse Cochlea." Antioxidants 10, no. 10 (2021): 1526. http://dx.doi.org/10.3390/antiox10101526.

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Drug-induced hearing loss is a major type of acquired sensorineural hearing loss. Cisplatin and aminoglycoside antibiotics have been known to cause ototoxicity, and excessive accumulation of intracellular reactive oxygen species (ROS) are suggested as the common major pathology of cisplatin- and aminoglycoside antibiotics-induced ototoxicity. Fursultiamine, also called thiamine tetrahydrofurfuryl disulfide, is a thiamine disulfide derivative that may have antioxidant effects. To evaluate whether fursultiamine can prevent cisplatin- and kanamycin-induced ototoxicity, we investigated their preve
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Yoshida, Naohiro, M. Charles Liberman, M. Christian Brown, and William F. Sewell. "Gentamicin Blocks Both Fast and Slow Effects of Olivocochlear Activation in Anesthetized Guinea Pigs." Journal of Neurophysiology 82, no. 6 (1999): 3168–74. http://dx.doi.org/10.1152/jn.1999.82.6.3168.

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The medial olivocochlear (MOC) efferent system, which innervates cochlear outer hair cells, suppresses cochlear responses. MOC-mediated suppression includes both slow and fast components, with time courses differing by three orders of magnitude. Pharmacological studies in anesthetized guinea pigs suggest that both slow and fast effects on cochlear responses require an initial acetylcholine activation of α-9 nicotinic receptors on outer hair cells and that slow effects require additional intracellular events downstream from those mediating fast effects. Gentamicin, an aminoglycoside antibiotic,
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Nakagawa, T., S. Kakehata, N. Akaike, S. Komune, T. Takasaka, and T. Uemura. "Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea." Brain Research 580, no. 1-2 (1992): 345–47. http://dx.doi.org/10.1016/0006-8993(92)90966-d.

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O’Sullivan, Mary E., Yohan Song, Robert Greenhouse, et al. "Dissociating antibacterial from ototoxic effects of gentamicin C-subtypes." Proceedings of the National Academy of Sciences 117, no. 51 (2020): 32423–32. http://dx.doi.org/10.1073/pnas.2013065117.

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Gentamicin is a potent broad-spectrum aminoglycoside antibiotic whose use is hampered by ototoxic side-effects. Hospital gentamicin is a mixture of five gentamicin C-subtypes and several impurities of various ranges of nonexact concentrations. We developed a purification strategy enabling assaying of individual C-subtypes and impurities for ototoxicity and antimicrobial activity. We found that C-subtypes displayed broad and potent in vitro antimicrobial activities comparable to the hospital gentamicin mixture. In contrast, they showed different degrees of ototoxicity in cochlear explants, with
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Beitel, Ralph E., Russell L. Snyder, Christoph E. Schreiner, Marcia W. Raggio, and Patricia A. Leake. "Electrical Cochlear Stimulation in the Deaf Cat: Comparisons Between Psychophysical and Central Auditory Neuronal Thresholds." Journal of Neurophysiology 83, no. 4 (2000): 2145–62. http://dx.doi.org/10.1152/jn.2000.83.4.2145.

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Cochlear prostheses for electrical stimulation of the auditory nerve (“electrical hearing”) can provide auditory capacity for profoundly deaf adults and children, including in many cases a restored ability to perceive speech without visual cues. A fundamental challenge in auditory neuroscience is to understand the neural and perceptual mechanisms that make rehabilitation of hearing possible in these deaf humans. We have developed a feline behavioral model that allows us to study behavioral and physiological variables in the same deaf animals. Cats deafened by injection of ototoxic antibiotics
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Dissertations / Theses on the topic "Antibiotic effects on cochlea"

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Wright, A. "Structural changes in the human cochlea during drug treatment." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371567.

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Berninger, Erik. "Quinine as a model for the study of cochlear hearing loss in humans /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4272-2/.

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Chin, Alex C. "Anti-inflammatory effects of the macrolide antibiotic tilmicosin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ31336.pdf.

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El-Sabbagh, Nasser Mohamed. "Effects of dissolved carbon dioxide on antibiotic production." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415315.

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Khan, David D. "Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282604.

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Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. Based on in silico mathematical models, describing the time course of exposure (Pharmacokinetics, PK) and effect (Pharmacodynamics, PD) of a drug, information can be collected and the outcome of various exposures may be predicted. A general mode
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Webb, Jason Crispin John. "The Effects of Antibiotic Combinations on Bone Cement Properties." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525435.

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Wikblom, Ida. "Antibiotic Use and Effects in the Terminally Ill : – A Retrospective Review." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66978.

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Fisher, Morgane, (Dennison) Jaime Thomas, and Danielle Weimann. "Effects of an Educational Intervention on Parental Knowledge Regarding Antibiotic Resistance." The University of Arizona, 2008. http://hdl.handle.net/10150/624276.

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Class of 2008 Abstract<br>Objectives: To evaluate changes in parental knowledge regarding antibiotic use and antibiotic resistance with an educational intervention given at elementary school parent-teacher association (PTA) meetings. Methods: This was an analytical pre-test/post-test study of an educational intervention given at two elementary schools in the Phoenix metro area. The primary dependent variable was a knowledge measure, calculated as a total score. The changes between the pre- and post-test total score means were compared using a dependent t-test. The a-priori alpha level used wa
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Gbejuade, Herbert Olukayode. "The effects of antibiotic loaded bone cement combinations on bacteria biofilms." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705469.

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Gordon, C. A. "The contribution of alginate to the antibiotic susceptibility of Pseudomonas aeruginosa." Thesis, University of Brighton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384621.

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Books on the topic "Antibiotic effects on cochlea"

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Vekshin, N. L. Biophysics of DNA-antibiotic complexes. Nova Science Publishers, 2010.

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Enzybiotics: Antibiotic enzymes as drugs and therapeutics. John Wiley & Sons, 2010.

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Tackling antibiotic resistance from a food safety perspective in Europe. World Health Organization, 2011.

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Offit, Paul A. Breaking the antibiotic habit: A parent's guide to coughs, colds, ear infections, and sore throats. John Wiley, 1999.

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Audiovestibular toxicity of drugs. CRC Press, 1989.

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Wright, Jennifer Gordon. Use of anthrax vaccine in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. Dept. of Health and Human Services, Centers for Disease Control and Prevention, 2010.

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Amabile-Cuevas, Carlos F. Antibiotic Resistance. Eurekah.Com Inc, 2002.

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B, Levy Stuart, Novick Richard P. 1932-, Cold Spring Harbor Laboratory, United States. Environmental Protection Agency., and National Science Foundation (U.S.), eds. Antibiotic resistance genes: Ecology, transfer, and expression. Cold Spring Harbor Laboratory, 1986.

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S, Moore Wesley, and Gelabert Hugh A, eds. Antibiotic-impregnated vascular grafts. R.G. Landes, 1992.

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Enzybiotics: Antibiotic enzymes as drugs and therapeutics. John Wiley & Sons, 2010.

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Book chapters on the topic "Antibiotic effects on cochlea"

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Singer, Andrew C., and Heike Schmitt. "Antibiotic Use During an Influenza Pandemic: Downstream Ecological Effects and Antibiotic Resistance." In Antimicrobial Resistance in the Environment. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118156247.ch26.

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Gnarpe, Håkan, and Judy Belsheim. "Indirect Antibiotic Effects on Granulocyte Migration and Phagocytosis." In The Influence of Antibiotics on the Host-Parasite Relationship II. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70748-3_17.

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Frank, Uwe, and Evelina Tacconelli. "Antibiotics, Antimycotics: Spectrum – Dosage – Adverse Effects – Costs." In The Daschner Guide to In-Hospital Antibiotic Therapy. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-18402-4_9.

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Forni, C., E. Tel-Or, E. Bar, and M. Grilli Caiola. "Effects of antibiotic treatments on Azolla-Anabaena and Arthrobacter." In Nitrogen Fixation. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3486-6_95.

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D’Angelo, Salvo, Marcello Masili, and Riccardo Malvano. "Linear and Non-Linear Effects in a Physical Model of the Cochlea." In Lecture Notes in Biomathematics. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-50038-1_35.

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Andersson, Dan I., and Diarmaid Hughes. "Effects of Antibiotic Resistance on Bacterial Fitness, Virulence, and Transmission." In Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815639.ch26.

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Bamigboye, Olutoyin Omolara, and Idowu Jesulayomi Adeosun. "Antimicrobial Compounds from Medicinal Plants: Effects on Antibiotic Resistance to Human Pathogens." In The Therapeutic Properties of Medicinal Plants. Apple Academic Press, 2019. http://dx.doi.org/10.1201/9780429265204-6.

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Schultz, Markus J., and Peter E. Spronk. "The Effects of Hand-Washing, Restrictive Antibiotic Use and SDD on Morbidity." In Selective Digestive Tract Decontamination in Intensive Care Medicine: a Practical Guide to Controlling Infection. Springer Milan, 2008. http://dx.doi.org/10.1007/978-88-470-0653-9_7.

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Hashmi, Muhammad Zaffar, Adeel Mahmood, Dambaru Ballab Kattel, Sohaib Khan, Ahmad Hasnain, and Zulkifl Ahmed. "Antibiotics and Antibiotic Resistance Genes (ARGs) in Soil: Occurrence, Fate, and Effects." In Soil Biology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47744-2_4.

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Szentivanyi, Andor, Herman Friedman, Günther Gillissen, and Judith Szentivanyi. "Immunomodulatory Effects of Some Antibiotic-Induced Changes in Bacterial and Host Determinants." In Antibiosis and Host Immunity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1901-6_1.

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Conference papers on the topic "Antibiotic effects on cochlea"

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Qiu, Fan, Li Meng, Hao Jin, and Jun Chen. "Effects of a Restrictive Antibiotic Policy on Antibiotic Usage and Staphylococcus Aureus Resistance." In International Conference on Electronics, Mechanics, Culture and Medicine. Atlantis Press, 2016. http://dx.doi.org/10.2991/emcm-15.2016.97.

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Ramlachan, N., T. L. Poole, W. K. Kim, et al. "Effects of antibiotic-suppelmented media on recovery of enterobacteria." In Sixth International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork. Iowa State University, Digital Press, 2005. http://dx.doi.org/10.31274/safepork-180809-788.

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Hamao, Nobuyoshi, Isao Ito, Satoshi Konishi, Naoya Tanabe, Issei Oi, and Toyohiro Hirai. "Frequency of side effects in antibiotic treatment for pneumonia." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4552.

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Karamova, Kamalya. "EFFECTS OF COMPOST CONTAINING ANTIBIOTIC RESISTANT GENES ON SOIL CHARACTERISTICS." In 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/5.2/s20.040.

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Arora, Shuchi, Chu Sing Lim, and Carl Baptista. "Screening of Antibiotic-Maggot Serum Combinations and Their Effects on Bacterial Physiology." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516865.

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Skweres, Joyce A., Virginia J. Bassinger, and S. K. Mishra, and Duane L. Pierson. "Effects of Refrigerating Preinoculated Vitek Cards on Microbial Physiology and Antibiotic Susceptibility." In International Conference On Environmental Systems. SAE International, 1992. http://dx.doi.org/10.4271/921214.

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Babic, Sandra, Davor Ljubas, Durdica Ivanec Sipusic, Lidija Curkovic, and Jasmina Beganovic. "Effects of pH and water matrix on photoinduced degradation of antibiotic cefdinir." In The 4th World Congress on Civil, Structural, and Environmental Engineering. Avestia Publishing, 2019. http://dx.doi.org/10.11159/iceptp19.118.

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"Effects of Scenedesmus microalgae and virginiamycin antibiotic on blood parameters of broiler chicks." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.214.

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Sequeira, Damien, Christian Breuninger, Albrecht Eiber, and Alexander Huber. "THE EFFECTS OF COMPLEX STAPES MOTION ON THE RESPONSE OF THE COCHLEA IN GUINEA PIGS." In Proceedings of the 4th International Symposium. WORLD SCIENTIFIC, 2007. http://dx.doi.org/10.1142/9789812708694_0017.

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CILTAS, ABDULKADIR, and YUSUF ZEKERIYA. "Effects of Oxytetracycline Antibiotic on GST Enzyme Activity and Gene Expression Levels in Rainbow Trout." In Fifth International Conference On Advances in Applied Science and Environmental Technology- ASET 2016. Institute of Research Engineers and Doctors, 2016. http://dx.doi.org/10.15224/978-1-63248-106-1-32.

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Reports on the topic "Antibiotic effects on cochlea"

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Oliveira, Mariana, Vívian Souza, Guilherme Tavares, Rodrigo Fabri, and Ana Carolina Apolônio. Effects of antibiotic-loaded chitosan nanoparticles against resistant bacteria: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.6.0069.

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Teixeira, Jaclyn. Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.5263.

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Block, Jason, Christopher Forrest, Douglas Lunsford, Juliane Reynolds, and Bridget Nolan. Looking at the Effects of Antibiotic Use on Childhood Obesity and Growth -- The PCORnet® Antibiotics Study. Patient-Centered Outcomes Research Institute (PCORI), 2020. http://dx.doi.org/10.25302/10.2020.obs.150530699.

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Evidence Update for Clinicians: Narrow- versus Broad-Spectrum Antibiotics for Common Infections in Children. Patient-Centered Outcomes Research Institute (PCORI), 2018. http://dx.doi.org/10.25302/eu5.2018.10.

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Comparing Narrow- vs. Broad-Spectrum Antibiotics for Common Infections in Children. The choice of antibiotic to treat acute bacterial upper respiratory tract infections in children can affect both symptom resolution and the risk of side effects such as diarrhea and vomiting. The findings of a PCORI-funded study published in JAMA can help clinicians treating children for acute respiratory tract infections (ARTIs)—including acute otitis media, Group A streptococcal pharyngitis, and acute sinusitis—make decisions with parents about the medicine that is best for the child. The study, led by Jeffre
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