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Dissertations / Theses on the topic 'Antibiotic resistance bacteria (ARB)'

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Published: 9 March 2023
Last updated: 31 July 2025

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1

Wind, Lauren Lee. "Persistence of Culturable Antibiotic Resistant Fecal Coliforms From Manure Amended Vegetable Fields." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86262.

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The reduced efficacy of antibiotics in treating common infections is one of the most pressing health concerns of the 21st Century. Increasing evidence links the widespread use of antibiotics in livestock production to the transfer of bacteria carrying antibiotic resistance genes to the broader environment. It is therefore critical to understand the persistence and dissemination of resistance in agricultural soils to understand potential threats to consumers. The goal of this large-scale agricultural field experiment was to identify the effects of crop (lettuce, radish) and fertilizer type (ino
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2

Riquelme, Breazeal Maria Virginia. "Improved monitoring of emerging environmental biocontaminants through (nano)biosensors and molecular analyses." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/83419.

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Outputs of human-derived chemicals and constituents to the environment, and shifts in these outputs, can result in unintended consequences to human and ecological health. One such shift is the advent of the modern antibiotic era, in which mass production and outputs of antibiotics, which are mostly naturally-derived microbial defense compounds and include a few synthetic antimicrobials, has profound implications for contributing to the spread of antibiotic resistance. Antibiotic resistance arises from mutations and/or sharing of antibiotic resistance genes (ARGs) among bacteria via horizontal
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3

Williams, Robert Kyle. "Effect of Composting on the Prevalence of Antibiotic Resistant Bacteria and Resistance Genes in Cattle Manure." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/74952.

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Antibiotic resistance is a growing human health threat, making infections more difficult to treat and increasing fatalities from and cost of treatment of associated diseases. The rise of multidrug resistant pathogens threatens a return to the pre-antibiotic era where even the most common infections may be impossible to treat. It is estimated that the majority of global antibiotic use, and use in the U.S., is dedicated towards livestock, where they are used to promote growth, treat, or prevent disease. Given that exposure to antibiotics selects for antibiotic resistant bacteria (ARBs) and can s
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4

RIVA, FRANCESCO. "ANTIBIOTIC RESISTANCE SPREAD MEDIATED BY HORIZONTAL GENE TRANSFER IN THE AGRI-FOOD ECOSYSTEM." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/914666.

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Antibiotic resistance (AR) is a public problem for human health and food safety. Globalization has contributed to create an intense connection among human and animal health and the environment, allowing bacteria and their genes to move among all these compartments, making a “one-health approach” necessary to counteract this phenomenon. Horizontal gene transfer (HGT), which contributes to AR determinants diffusion, is mediated by three main mechanisms: i) conjugation, ii) transduction, and ii) natural transformation. Several environments linked to the agri-food system are both sources of AR det
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5

Hiliare, Sheldon. "Impact of Manure Land Management Practices on Manure Borne Antibiotic Resistant Elements (AREs) in Agroecosystems." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/102218.

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Rising global antibiotic resistance has caused concerns over sources and pathways for the spread of contributing factors. Majority of the antimicrobials used in the U.S. are involved in veterinary medicine, primarily with livestock rearing. Animal manure land application integrates livestock farming and agroecosystems. This manure contains antibiotic resistant elements (AREs) (resistant bacteria, resistance genes, and veterinary antibiotics) that contribute towards antimicrobial resistance. Altering manure application techniques can reduce surface runoff of other contaminants such as excess N
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6

Zhang, Lu. "Establishment and Development of Antibiotic Resistant Bacteria in Host Gastrointestinal Tract—Food, Drug, or Are We Born with It?" The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316186957.

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7

Nagulapally, Sujatha Reddy. "Antibiotic resistance patterns in municipal wastewater bacteria." Thesis, Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/331.

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8

Roe, Darcie Elizabeth. "Prevalence and mechanisms of antibiotic resistance in oral bacteria." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9310.

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9

Melnyk, Anita. "The Evolution of Antibiotic Resistance in Experimental Populations of Bacteria." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34556.

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Antibiotic resistance is a major threat to public health. Understanding how it evolves, and the genes that underlie resistance, is the main goal of my Ph.D. research. After a resistance mutation arises, it’s fate within a pathogen population will be etermined in part by its fitness: mutations that suffer little or no fitness cost are more likely to persist in the absence of antibiotic treatment. My research centers on understanding this process better by gaining knowledge about the spectrum of fitness effects associated with antibiotic resistance mutations. Using a meta-analysis framework I
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10

Suarez, Rachel. "Chemical disinfectant resistance in multiple antibiotic resistant and susceptible bacteria." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ57585.pdf.

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11

Lillro, Ejla. "Image Sensor System for Detection of Bacteria and Antibiotic Resistance." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-179399.

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Antibiotic resistance is now a recognized problem in global health. In attempts to find solutions to detect bacteria causing antibiotic resistance we turn to technological solutions that are miniaturized, portable and cheap. The current diagnostic procedures cannot provide correct information outside laboratory settings, at the point-of-care, within necessary time. This has led to ineffective treatment of urinary tract infections causing recurrent infections and multi-drug resistant bacteria to spread. The bacteria genes show which antibiotic that is required to eliminate disease and spread of
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12

Gallagher, L. K., Brian G. Evanshen, Kurt J. Maier, and Phillip R. Scheuerman. "Bacterial Source Tracking in the Sinking Creek Watershed, using Antibiotic Resistance Analysis (ARA) and Ribotyping." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/2946.

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13

Leonard, Anne Frances Clare. "Are bacteria in the coastal zone a threat to human health?" Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/22805.

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Faecal pollution regularly contaminates surface waters, introducing microorganisms, including bacteria and bacteria resistant to antibiotics, to coastal waters. People can come into contact with these potentially harmful microbes when they enjoy recreational activities in the sea. Understanding the risk to bathers of acquiring infections from the sea is important for developing effective intervention strategies to protect human health. This thesis consists of four original studies which aim to answer the question ‘are bacteria in the coastal zone a threat to human health’? First, we describe a
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14

Hernández, Jorge. "Human Pathogens and Antibiotic Resistant Bacteria in Polar Regions." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230700.

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Coincident with human activity in recent decades, human-associated microorganisms have arrived to the Antarctic region, possibly linked to increasing presence of scientific bases and ship-borne tourists. In the Arctic, humans have been present for a very long time, and the few parts of the Arctic without human activities is decreasing with time. The studies in this thesis investigate the occurrence of different pathogens in Antarctic and Arctic wildlife, especially in birds. The first study shows the existence of Enteropatogenic Escherichia coli (EPEC) in Antarctic fur seals. The EPEC isolates
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15

Jacobs, Kyle Bowers. "Recovery of Antibiotic Resistance Genes From Agricultural Runoff." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/88743.

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The reduced capacity of antibiotics to treat infections is one of the greatest health concerns that society faces. There is substantial evidence that links this reduced capacity with the widespread use of antibiotics in livestock production. Livestock can act as reservoirs of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria, which can pass resistance on in the livestock's manure. It is important to understand the fate of antibiotic resistance genes and resistant bacteria in the environment after land-application of manure-based amendments. The goal of this field-scale study
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16

Davis, Ian Jonathan. "Characterisation of heavy metal & antibiotic resistance genes in oral bacteria." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408917.

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17

Ahmen, Mohamed Omar Basher. "Zoonotic bacteria and antibiotic resistance in the GI tract of horses." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425475.

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18

Mak, Jennifer Ka Yan Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Integrons, resistance genes and their dissemination (in Gram- Negative Bacteria)." Awarded By:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44381.

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Antibiotic resistance is increasing worldwide, which is threatening the effectiveness of even the most potent and recent antibiotics. The successful treatment of disease is hampered due to the multidrug resistant (MDR) phenotype exhibited by the bacterial pathogens. Therefore, the aims of this thesis were to investigate MDR through several different approaches. Integrons are important contributors to the MDR profile of nosocomial isolates within Australia, therefore the incidence of integrons was assessed in a collection of 72 conjugative clinical plasmids isolated from E. coli, a cohort of
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19

Darko, Janice. "Fluorescent Labeling of Antibiotic Resistant Bacteria Model DNA." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7600.

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Global threats to treatment of bacterial infections due to antibiotic resistance (AR) have been on the rise in recent years. Current diagnostic tests identify bacteria by using blood culture, which takes more than 24 hours. This study focuses on the fluorescent labeling of DNA derived from bacterial AR genes (KPC & VIM) and other model DNAs using oligreen dye (OG) and molecular beacons (MB). A NanoDrop 3300 fluorospectrometer was used to take fluorescence measurements. Linear dynamic range and labeling efficiency were dependent on the following optimized conditions: dilution factor of OG (200
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20

DeSilva, Malini. "Efficacy of Print Media Risk Communication About Antibiotic Resistance." Thesis, Boston College, 2003. http://hdl.handle.net/2345/427.

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Thesis advisor: Roche P. John<br>The growing threat of antibiotic resistance makes it extremely important that citizens be informed about the risks posed by antibiotic-resistant bacteria, and measures with which they can reduce these risks. The print media are major sources of such information for members of the public. In the present study, articles from major newspapers in the United States and Canada appearing between 1998 and 2002 were surveyed to determine the extent to which mention was made of antibiotic resistance and the risks associated with antibiotic resistance, the contextual prec
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21

Barbosa, Teresa Maria Leite Martins. "Tetracycline resistance transfer among obligate anaerobes from the ruminant gut." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286850.

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The main aim of this work was to investigate the nature, distribution and transmissibility of tetracycline resistance (Tc<sup>R</sup>) genes among ruminant anaerobic bacteria. Two Tc<sup>R</sup> rumen strains of <I>Butyrivibrio fibrisolvens,</I> 1.230 and 1.23, were able to transfer the resistance phenotype to the type strain, 2221<sup>R</sup> although a third Tc<sup>R</sup> strain, 1.210, could not. PCR amplification of 16S rDNA sequences showed that the three isolates were phylogenetically distinct from the recipient strain, but related to each other. Hybridisation work suggested the presenc
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22

Al-Khateeb, Mohammed Jihad M. Jalal. "Investigation into the epidemiology of multi-drug resistance plasmids of hospital-associated coliform bacteria." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243028.

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23

Vasilenko, Sofia, and Софія Василенко. "Bacteria resistance to beta-lactam antibiotics." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50637.

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1. Pulok K. Mukherjee. Quality Control and Evaluation of Herbal Drugs: Evaluating Natural Products and Traditional Medicine. Elsevier, 2019. 762 p. 2. Kumar A., Schweizer H. Bacterial resistance to antibiotics: Active efflux and reduced uptake. Adv. Drug Deliv. Rev. 2005. Vol. 57. P. 513. 3. Antimicrobial Resistance: Tackling a Crisis for the Future Health and Wealth of Nations. Chaired by Jim O’Neill. London: Review on Antimicrobial Resistance. 2014. 16 p. 4. Thomas C. M., Nielsen K.M. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat. Rev. Microbiol. 2005. Vol. 3
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24

Mwansa, J. C. L. "Antibiotic resistance in salmonella and shigella in the Manchester region 1981 - 1984." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378363.

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25

Leng, Zhongtai. "Distribution and mobility of antibiotic resistant genes in oral/urogentital [sic] bacteria." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9273.

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26

Wallace, Jeremy Iain. "Hyperinducible β-lactamase expression in gram-negative bacteria." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295568.

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27

Smith, Lisa Marie. "Antibiotic resistance and coliform bacteria in the Ohio River; 2002 to 2004." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=679.

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Theses (M.S.)--Marshall University, 2006.<br>Title from document title page. Includes abstract. Document formatted into pages: contains vii, 73 p. including illustrations and maps. Bibliography: p. 25-28.
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28

Gullberg, Erik. "Selection of Resistance at very low Antibiotic Concentrations." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235225.

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The extensive medical and agricultural use and misuse of antibiotics during the last 70 years has caused an enrichment of resistant pathogenic bacteria that now severely threatens our capacity to efficiently treat bacterial infections. While is has been known for a long time that high concentrations of antibiotics can select for resistant mutants, less is known about the lower limit at which antibiotics can be selective and enrich for resistant bacteria. In this thesis we investigated the role of low concentrations of antibiotics and heavy metals in the enrichment and evolution of antibiotic r
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29

Erlandsson, Marcus. "Surveillance of Antibiotic Consumption and Antibiotic Resistance in Swedish Intensive Care Units." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1019s.pdf.

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30

Robinson, Hannah Kathleen. "Antibiotic resistance in Gram negative bacteria isolated from fish sold in Western Australia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2161.

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Background Information The global misuse and overuse of antibiotics in human medicine and the animal production industry is contributing to the development of antibiotic resistance in bacteria. This is a serious threat to modern medicine and public health. Antibiotic resistant organisms can cause severe infections in humans which are difficult to treat, and in some cases impossible to resolve which can lead to premature death. Several studies have been conducted across the globe to assess the use of antibiotics in the seafood industry and the associated health risks, however, limited studies h
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31

Knecht, Camila Ayelén [Verfasser], and Heinz [Gutachter] Köser. "Fate of antibiotic resistant bacteria and antibiotic resistance genes in constructed wetlands / Camila Ayelén Knecht ; Gutachter: Heinz Köser." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://d-nb.info/1219966215/34.

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32

Tlachac, Monica. "Tackling the Antibiotic Resistant Bacteria Crisis Using Longitudinal Antibiograms." Digital WPI, 2018. https://digitalcommons.wpi.edu/etd-theses/1318.

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Antibiotic resistant bacteria, a growing health crisis, arise due to antibiotic overuse and misuse. Resistant infections endanger the lives of patients and are financially burdensome. Aggregate antimicrobial susceptibility reports, called antibiograms, are critical for tracking antibiotic susceptibility and evaluating the likelihood of the effectiveness of different antibiotics to treat an infection prior to the availability of patient specific susceptibility data. This research leverages the Massachusetts Statewide Antibiogram database, a rich dataset composed of antibiograms for $754$ ant
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33

Lancaster, Holli Louise. "The persistence and genetic support of genes encoding antibiotic resistance in oral bacteria." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444918/.

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Antibiotic-resistant bacteria present a serious public health threat and studies investigating the prevalence of antibiotic-resistant bacteria and the genes encoding for antibiotic resistance (GEAR) are essential. Such studies help us to understand how antibiotic-resistant bacteria and GEAR are obtained, transferred and maintained within a population. The aim of this study was to identify the prevalence and maintenance of antibiotic-resistant bacteria in the oral microbiota of children aged 4-6 years who had not previously taken antibiotics. Bacteria resistant to penicillin, ampicillin, tetrac
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34

Olofsson, Sara K. "Relation Between Drug Exposure and Selection of Antibiotic Resistant Bacteria." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7197.

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35

Levengood, Enjolie. "The effect of combined sewer overflows on the abundance of antibiotic resistance genes and bacteria in the James River." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5179.

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Antibiotic resistance is a major threat to human health. Clinical situations are the main focus for antibiotic resistance research, but understanding the spread of resistance in the environment is also vital. A major contributor to this spread is wastewater from combined sewer overflow (CSO) events. The effect of CSO events on antibiotic resistance in the James River near Richmond, Virginia was studied using genomic and microbiological approaches. The abundance of genes associated with resistance to quinolones (qnrA) and tetracycline (tetW) was strongly correlated with the presence of fecal in
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36

Ozaktas, Tugba. "Multiple Antibiotic Resistance Of Surface Mucus Dwelling Bacterial Populations In Freshwater Fish." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12609113/index.pdf.

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Surface mucus of a freshwater fish, Alburnus alburnus (bleak), caught from Lake Mogan, situated in south of Ankara, was collected in different seasons. The total cultivable bacteria were enumerated by spread plate method on nine different media. Bacteria were isolated based on colony morphologies and pigmentation. A total of sixty bacterial isolates obtained. The mucus-dwelling bacteria were first tested for resistance against ampicillin and kanamycin<br>then streptomycin and chloramphenicol were added to the experimental set up. The resistance levels of isolates were determined in terms of fo
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37

BERTINI, ALESSIA. "Plasmid-mediated antimicrobial resistance in Gram-negative bacteria." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/641.

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L’epidemiologia dei plasmidi di resistenza è il principale mezzo per descrivere la diffusione delle resistenze agli antimicrobici. L’identificazione di plasmidi correlati associati a specifici geni di resistenza può aiutare a tracciare la disseminazione di plasmidi epidemici, aprendo nuovi scenari epidemiologici sui meccanismi di diffusione delle resistenze agli antimicrobici. Questo aspetto è particolarmente evidente quando si considerano plasmidi che sono associati alla diffusione delle Beta Lattamasi a Spettro Esteso (ESBL) come gli enzimi CTX-M, SHV, TEM. Lo scopo di questa tesi è st
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38

Woodford, Jennifer. "The Threat of Antibiotic Resistant Bacteria: The Role of EF-P and EpmA in Antibiotic Resistant E. coli." Ohio Dominican University Honors Theses / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620140308432787.

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39

Norgren, Benjamin. "What role does aquaculture play in the global rise of antibiotic-resistant bacteria?" Thesis, Stockholms universitet, Institutionen för ekologi, miljö och botanik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-182602.

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In a world where the human population is increasing, new innovations to produce enough food are required. Aquaculture’s part of the global animal protein production has increased in recent years and could be a possible solution. However, if aquaculture is poorly managed, it can result in negative consequences and one such consequence is the development of antibiotic resistance. In this review, I examine how aquaculture affect antibiotic resistance by studying what the literature says on accumulation of antibiotics in different organisms and sediment, if antibiotics can be transferred to humans
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40

El, Salabi Allaaeddin Ali. "Characterisation of antibiotic resistance mechanisms in Gram-negative bacteria from Tripoli and Benghazi, Libya." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55122/.

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As very little information is known of the antibiotic resistance in Gram-negative bacteria in Libya in addition to the desperate need for insight knowledge of the antibiotic resistance in Libyan hospitals, this study was undertaken to investigate the mechanism of antibiotic resistance in isolates collected from clinical, non-clinical and environmental samples from Tripoli and Benghazi, Libya. Bacterial collection include samples taken from patients admitted to the hospitals in ICUs and other wards, they also include swabs randomly collected from hospitals environment. These swabs were from wal
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41

Sharkey, Liam Karl Robert. "Functional insights into ABC-F proteins that mediate antibiotic resistance in Gram-positive bacteria." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12924/.

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Members of the ABC-F subfamily of ATP-binding cassette (ABC) proteins mediate resistance to a broad array of clinically-important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which the ABC-F proteins mediate antibiotic resistance is poorly defined, although two hypotheses have been proposed; drug efflux and ribosomal protection. Here, this mechanism of resistance was investigated using a combination of bacteriological and biochemical techniques. Results obtained from the bacteriological assays provided preliminary data in support of ribosomal protect
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42

Ferro, Giovanna. "Wastewater disinfection by AOPs: effect on antibiotic resistance and contaminants of emerging concern." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2473.

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43

Pulido, Natalie Anne. "Effect of Standard Post-harvest Interventions on the Survival and Regrowth of Antibiotic-Resistant Bacteria on Fresh Produce." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/83528.

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Raw vegetables can sometimes be the source of outbreaks of human illness; however the potential for fresh vegetables to serve as a vehicle for antibiotic -resistant bacteria is poorly understood. Antibiotics and antibiotic-resistant bacteria have been shown to persist in manure of animals administered antibiotics, and in compost generated from this manure, where there is the potential for their transfer to produce. The purpose of this study was to determine the survival of antibiotic-resistant bacteria on raw, peeled, carrots after washing with commonly used chemical sanitizers. Multi-drug res
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44

Van, Thi Thu Hao, and thuhao2007@gmail com. "Detection of Enteric Bacteria in Raw Food Samples from Vietnam and Evaluation of Antibiotic Resistance." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20090407.141836.

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This study was conducted to examine the rate of contamination and molecular characteristics of enteric bacteria isolated from a selection of food sources in Vietnam. One hundred and eighty raw food samples were tested and 60.8% of meat and 18.0% of shellfish samples were found to be contaminated with Salmonella spp. which belonged to variety of serogroups and serotypes. More than 90% of all food sources contained Escherichia coli and 32% of 50 shellfish samples were contaminated with Vibrio parahaemolyticus. PFGE was used to determine the degree of relatedness of Salmonella spp. There were
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45

Heard, R. G. "An investigation of the antibiotic resistance genes in bacteria isolated from a veal calf rearing farm." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233597.

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46

Kinkelaar, Daniel Francis. "Profiles of Tetracycline Resistant Bacteria in the Human Infant Digestive System." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213330709.

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47

Redgrave, Liam Stephen. "The role of supercoiling in altering chromosome structure, gene expression and antibiotic resistance in bacteria." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7912/.

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Antibiotic resistance is a major problem estimated to cost $100 trillion and cause 10 million deaths per year by 2050. Despite novel molecules targeting Gram-positive bacteria, there are no new antibiotics active against Gram-negatives. To prolong use of current drugs, we need to understand mechanisms of resistance to inform prescribing practices and drug discovery. Quinolone resistance is primarily conferred by mutations in the target loci: DNA gyrase (gyrA) and topoisomerase IV. Quinolone resistance arising from gyrA mutations has also been shown to confer a low level of protection against a
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48

SENNATI, SAMANTA. "MOLECULAR EPIDEMIOLOGY OF EMERGING ANTIBIOTIC RESISTANCE MECHANISMS IN COMMENSAL AND PATHOGENIC BACTERIA IN LATIN AMERICA." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1004558.

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Bacterial resistance to antibiotics is a major public health problem, and the increasing spread of multi-resistant isolates represents an alarming challenge due to the limited treatment options for infections caused by these pathogens. This phenomenon is an important concern in low resource countries like those of Latin America, where the combination of factors such as inefficient health systems, poor sanitation and uncontrolled use of antimicrobials provide conditions to develop and maintain resistant strains in the hospital settings, at the community level and in the environment. In this w
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49

McCarthy, Kelly A. "Exploiting Dynamic Covalent Binding for Strain-Specific Bacterial Recognition:." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108513.

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Thesis advisor: Eranthie Weerapana<br>Antibiotic resistance of bacterial pathogens poses an increasing threat to the wellbeing of our society and urgently calls for new strategies for infection diagnosis and antibiotic discovery. The overuse and misuse of broad-spectrum antibiotics has contributed to the antibiotic resistance crisis. Additionally, treatment of infections with broad-spectrum antibiotics can cause disruption to the host gut microbiome. The development of narrow-spectrum antibiotics would be ideal to avoid unnecessary cultivation of antibiotic resistance and damage to the human m
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50

Qian, Leilei. "Evaluation of Antibiotic Resistance Profiles of Enteric Bacteria in Swine Feces Before and After Lagoon Treatment." NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-05082007-161836/.

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Antibiotics are used in livestock production for the treatment of diseases and for improvement of feed efficiency and growth. However, agricultural use of antibiotics may be partly responsible for the emergence of antibiotic-resistant organisms. Large amounts of managed manure are land applied, which opens the door for the spread of antibiotic resistance in the environment. Thus, the goal of this project was to evaluate the effects of lagoon treatment on the persistence of antibiotic resistant enteric bacteria isolated from swine feces. Both cool season and warm season samples were collected f
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