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Journal articles on the topic 'Antibiotic susceptibility variation'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ho, Macy, Elizabeth R. Armstrong, Christopher J. Graber, et al. "1011. Hospital Antibiogram Variation within a Veterans Affairs (VA) Regional Network." Open Forum Infectious Diseases 6, Supplement_2 (2019): S355—S356. http://dx.doi.org/10.1093/ofid/ofz360.875.

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Abstract Background VISN 22 is comprised of eight VA hospitals serving Southern California, Arizona, and New Mexico. The VISN 22 Antimicrobial Stewardship Workgroup formed in November 2018 with the purpose of sharing strong practices and program strategies. We compared antibiogram compilation strategies and antimicrobial susceptibilities and correlated antimicrobial susceptibilities for Pseudomonas aeruginosa and Escherichia coli with inpatient and outpatient antibiotic use. Methods 2018 antibiograms were collected from each hospital. Antibiotic utilization rates (antibiotic days per 1000 pati

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Bao Tran, Pham, Nguyen Anh Thu, and Tong Thi Hang. "Effect of commercial probiotics and antibiotics on the growth of Campylobacter isolated from chicken meat in Ho Chi Minh city markets." Vietnam Journal of Biotechnology 21, no. 3 (2024): 549–63. http://dx.doi.org/10.15625/1811-4989/19755.

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This study explores the antibiotic susceptibility of Campylobacter, a prominent foodborne pathogen, isolated in Ho Chi Minh city markets and the efficacy of commercial probiotics in inhibiting these bacteria for enhancing food safety and treating Campylobacter infections. Bacteria were isolated from chicken meat in modified coal deoxycholate cefoperazone agar (mCCD), followed by characterization as per standard procedures. Ten isolates with Gram negative, catalase positive and oxidase positive characteristics were collected. Antibiotic susceptibility is ascertained through the determination of

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Mwanzo Wavindu, Edith B. Mouafo Tamnou, Ildephonse Soly Kamwira, et al. "Susceptibility of some Enterobacteriaceae isolated from 4 different aquatic environments in DR Congo (Central Africa), to Amoxicillin/Clavulanic acid and some 3rd generation Cephalosporins." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 178–90. http://dx.doi.org/10.30574/gscbps.2024.26.1.0002.

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Little is known about the variation of the antibiotic susceptibility of different bacterial strains of the same cells species, isolated from different aquatic environments. The present study aims to evaluate the susceptibility towards some 3rd generation cephalosporins (Ceftriaxon, Ceftazidim and Cefotaxim) and Amoxicillin/Clavulanic acid, of Enterobacteriaceae strains isolated from groundwater, stream, hospital wastewater and slaughterhouse wastewater. Enterobacteria species were isolated on Mac Conkey agar, then identified using enzymatic and MALDI-TOF MS system. The antimicrobial susceptibi

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Habibah, Firda Nurul, Hafizah Ilmi Sufa, Iis Kurniati, and Zuri Rismiarti. "Effect of solvent variation on results of antibiotic susceptibility test using the disk diffusion method against Staphylococcus aureus." Current Biomedicine 3, no. 2 (2025): 60–66. https://doi.org/10.29244/currbiomed.3.2.60.

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Background Mueller-Hinton agar (MHA) is widely used for disk diffusion tests to assess antibiotic susceptibility in non-fastidious bacteria. The type of water used to prepare the MHA may have affected the test outcomes. Objective This study evaluated the effect of different water types as solvents on the antibiotic susceptibility test results of tetracycline and gentamicin against Staphylococcus aureus. Methods MHA was prepared using four types of water: distilled (control), bottled, reverse osmosis (RO), and municipal tap water (PDAM). Antibiotic susceptibility testing was performed using the

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Mwanzo, Wavindu, B. Mouafo Tamnou Edith, Soly Kamwira Ildephonse, et al. "Susceptibility of some Enterobacteriaceae isolated from 4 different aquatic environments in DR Congo (Central Africa), to Amoxicillin/Clavulanic acid and some 3rd generation Cephalosporins." GSC Biological and Pharmaceutical Sciences 26, no. 1 (2024): 178–90. https://doi.org/10.5281/zenodo.10969358.

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Little is known about the variation of the antibiotic susceptibility of different bacterial strains of the same cells species, isolated from different aquatic environments. The present study aims to evaluate the susceptibility towards some 3<sup>rd</sup> generation cephalosporins (Ceftriaxon, Ceftazidim and Cefotaxim) and Amoxicillin/Clavulanic acid, of Enterobacteriaceae strains isolated from groundwater, stream, hospital wastewater and slaughterhouse wastewater. Enterobacteria species were isolated on Mac Conkey agar, then identified using enzymatic and MALDI-TOF MS system. The antimicr

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Justen, Alexander M., Heather L. Hodges, Lili M. Kim, et al. "Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility." Science Advances 6, no. 38 (2020): eaba4015. http://dx.doi.org/10.1126/sciadv.aba4015.

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Bacteria control the length of their polysaccharides, which can control cell viability, physiology, virulence, and immune evasion. Polysaccharide chain length affects immunomodulation, but its impact on bacterial physiology and antibiotic susceptibility was unclear. We probed the consequences of truncating the mycobacterial galactan, an essential linear polysaccharide of about 30 residues. Galactan covalently bridges cell envelope layers, with the outermost cell wall linkage point occurring at residue 12. Reducing galactan chain length by approximately half compromises fitness, alters cell mor

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Menció, Anna, and Josep Mas-Pla. "Assessing the Influence of Environmental Factors on Groundwater Antibiotic Occurrence by Means of Variation Partitioning." Water 11, no. 7 (2019): 1495. http://dx.doi.org/10.3390/w11071495.

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The spatial distribution of antibiotics in alluvial aquifers presents a large variability caused by the joint action of several factors including hydrology, land use, and groundwater properties. In this study, the influences of these factors on the spatial variability of antibiotics is evaluated based on an extensive database of 47 wells located in the Baix Fluvià alluvial aquifer (NE Catalonia). Statistical methods such as redundancy and variation partitioning (VP) analyses, which are not commonly used in hydrogeological studies, are herein tested and used to estimate the effects of environme

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Okoye, Elochukwu Chidubem Sunday, Nnachetam Anthony Egudu, Nwamaka Anthonia Dibua, and Lydia Chidimma Okoye. "Seasonal Variation and Antibiotic Susceptibility Patterns of Bacteriological Parameters in Groundwater Sources in Oyi LGA, Anambra State, Nigeria." Journal of Advances in Microbiology 24, no. 5 (2024): 40–55. http://dx.doi.org/10.9734/jamb/2024/v24i5825.

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Potable water is essential for health and survival of all life forms. Contamination of groundwater sources by microbes, organic and inorganic matter has continued to negatively affect the well-being of most people in developing countries such as Nigeria. Thus, this study aimed to determine the seasonal variation and antibiotic susceptibility patterns of bacteriological parameters in groundwater sources in Oyi LGA, Anambra State, Nigeria. Hand-dug well and borehole water sites were randomly selected in five communities of Oyi LGA, and water samples were aseptically collected and analyzed using

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Tripathi, Kshama, and A. K. Sharma. "Seasonal variation in bacterial contamination of water sources with antibiotic resistant faecal coliforms in relation to pollution." Journal of Applied and Natural Science 3, no. 2 (2011): 298–302. http://dx.doi.org/10.31018/jans.v3i2.202.

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Water sample were collected from piped supplies, surface water and ground water sources in different locations of Lucknow city during summer, monsoon and winter season. Bacteriological quality of samples was determined by enumerating coliform isolated were subject to antibiotic susceptibility test with disc diffusion method. Maximum coliform and faecal coliform contamination were recorded during summer (67% and 75%) and monsoon (67% and 58.3%) while minimum during winter (50% and 50%). All the test isolates exhibited resistance (for nine antibiotics) was shown by river isolates. Antibiotic res

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KALMEGH, ANUP N., ANBAZHAGAN S, RAJNEESH RANA, ZUNJAR B. DUBAL, and PALLAB CHAUDHURI. "Antimicrobial susceptibility profiles of Mycoplasma mycoides subsp. capri field isolates from goats in India." Indian Journal of Animal Sciences 90, no. 8 (2021): 1123–25. http://dx.doi.org/10.56093/ijans.v90i8.109290.

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Erythromycin and Tylosin (Macrolides) followed by Tetracycline and Doxycycline (Tetracyclines) are found to be the best drugs of choice, under in-vitro antibiotic sensitivity test conducted with Disc diffusion method for the 10 Indian Mmc isolates recovered from goats. These relevant antibiotics may be recommended for use under field conditions. Although we have to keep in mind the gene exchange in Mollicutes along with other mechanisms, which may lead to the variation in their sensitivity to antibiotics in coming time.

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Thanasai, Jongkonnee, Sa-Ngob Laklaeng, Supphachoke Khemla, et al. "Global Prevalence of Antibiotic-Resistant Burkholderia pseudomallei in Melioidosis Patients: A Systematic Review and Meta-Analysis." Antibiotics 14, no. 7 (2025): 647. https://doi.org/10.3390/antibiotics14070647.

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Background: Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to multiple antibiotics, posing substantial challenges for treatment. Reports of acquired resistance are increasing, underscoring the need for global surveillance. Objective: This systematic review and meta-analysis aimed to determine the global prevalence of antibiotic-resistant B. pseudomallei isolated from human clinical cases, with a focus on regional differences and variations in antimicrobial susceptibility testing methods. Methods: We systematically searched PubMed, Scopus, and Embase f

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Hassan, Fatima J., Intesar N. Khelkal, Mohammed F. Al Marjani, and Amira A. Moawad. "The Effect of pH Variation on Antibiotic Susceptibility of MDR <i>Klebsiella pneumoniae</i> Isolates." Al-Mustansiriyah Journal of Science 35, no. 2 (2024): 37–42. http://dx.doi.org/10.23851/mjs.v35i2.1394.

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Background: Klebsiella pneumoniae is a significant opportunistic pathogen responsible for various nosocomial infections in humans. The emergence of multi-drug resistant strains poses a significant challenge in clinical settings, necessitating a deeper understanding of factors influencing antimicrobial resistance. Objective: This research aimed to investigate the impact of pH variation on the resistance patterns of multi-resistant K. pneumoniae isolated from Iraqi patients with urinary tract infections and wound infections against different antibiotics. Methods: Forty K. pneumoniae isolates wer

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Grujović, Mirjana, Tanja Žugić-Petrović, and Katarina Marković. "Safety assessment and antimicrobial potential of Enterococcus spp. isolated from raw goat milk and cheese." Kragujevac Journal of Science 46, no. 2 (2024): 49–62. https://doi.org/10.5937/kgjsci2402049g.

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This study aimed to assess the safety and antimicrobial properties of Enterococcus species isolated from raw goat milk and cheese. The isolates were evaluated for hemolytic activity on blood agar plates and antibiotic susceptibility by determining the minimum inhibitory concentrations (MICs) of five antibiotics: ampicillin, tetracycline, gentamicin, streptomycin, and vancomycin. Furthermore, the antagonistic activity of the Enterococcus strains against indicator bacteria was assessed using the agar-well diffusion method. Hemolytic activity results demonstrated a-hemolysis in all isolates. Amon

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Fenelon, Hannah T., Stephen E. Hawes, Hema Kapoor, Ann E. Salm, Jeff Radcliff, and Peter M. Rabinowitz. "Regional Variation in Urinary Escherichia coli Resistance Among Outpatients in Washington State, 2013–2019." Microorganisms 12, no. 11 (2024): 2313. http://dx.doi.org/10.3390/microorganisms12112313.

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Escherichia coli (E. coli) is a predominant pathogen of urinary tract infections (UTIs) in the United States. We analyzed resistance patterns by geographic location in Washington State to assess the need for regional antibiograms. The study included urinary E. coli antibiotic susceptibility tests performed by Quest Diagnostics on Washington outpatient isolates from 2013 to 2019. We conducted logistic regressions with robust standard errors for five antibiotics (ceftriaxone, ciprofloxacin, gentamicin, trimethoprim-sulfamethoxazole), with isolates classified as “susceptible” or “resistant” for e

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Motaweq, Zahraa Y., and Habeeb S. Naher. "Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq." Environmental & Socio-economic Studies 5, no. 2 (2017): 10–18. http://dx.doi.org/10.1515/environ-2017-0007.

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Abstract During the period from February 2013 to April 2014, 74 (12.3%) isolates of Streptococcus pneumoniae were isolated from 600 patients (359 males and 241 females) with clinical symptoms of Lower respiratory tract infections (LRTI) (pneumonia and COPD) obtained from Najaf/Iraq Hospitals. Patients in the age groups 51-60 years had a high percentage of S. pneumoniae isolates (19.7%) compared with other age groups with a significant variation (P<0.05) between them. Males (54%) showed a higher percentage of S. pneumoniae isolates than females (45.9%) with no significant variation (P>0.0

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Hicks, Nathan D., Samantha R. Giffen, Peter H. Culviner, et al. "Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis." PLOS Pathogens 16, no. 11 (2020): e1009063. http://dx.doi.org/10.1371/journal.ppat.1009063.

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Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics—even below this breakpoint—is associated with poor treatment outcomes in the clinic, including in tuberculosis. Clinical strains of Mycobacterium tuberculosis exhibit extensive quantitative variation in antibiotic susceptibility but the genetic basis behind this spectrum of drug susceptibility remains ill-defined. Through a genome wide association study, we show that non-synonymo

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Mo, Licai, Jiajia Wang, Jiao Qian, and Minfei Peng. "Antibiotic Sensitivity of Proteus mirabilis Urinary Tract Infection in Patients with Urinary Calculi." International Journal of Clinical Practice 2022 (December 21, 2022): 1–6. http://dx.doi.org/10.1155/2022/7273627.

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Background. The study’s objective was to determine Proteus mirabilis susceptibility in individuals with urinary tract infections and stones to antibiotics and prescribe optimal antimicrobial treatment. Methods. Nonrepetitive Proteus mirabilis strains were isolated from urine specimens obtained from 317 patients diagnosed with urinary stones from January, 2018, to December, 2021. A VITEK mass spectrometer was used for species identification, and a VITEK-compact 2 automatic microbial system was used for the antimicrobial susceptibility test (AST). Susceptibility to imipenem and cefoperazone/sodi

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Khattak, Zainab, Roohul Aala, Nimra Sani, et al. "Prevalence and antimicrobial susceptibility of Salmonella enterica Typhi in febrile patients: a cross-sectional study." Journal of Infection in Developing Countries 19, no. 06 (2025): 904–12. https://doi.org/10.3855/jidc.20373.

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Introduction: Typhoid fever, caused by Salmonella Typhi, is a serious health problem, especially in developing countries like Pakistan where antibiotics are usually prescribed without susceptibility testing or epidemiological surveillance. Consequently, antibiotic-resistant typhoid bacteria appear, but are not reported to the authorities. There is limited research on the prevalence and antibiotic susceptibility patterns of S. Typhi among febrile patients in Swabi, Pakistan. This study aimed to address this gap at the Bacha Khan Medical Complex in Swabi. Methodology: Laboratory records of hospi

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Dr, Duhita Jadhav. "Characterization and Antibiotic Susceptibility Testing Of Acinetobacter Species in a Tertiary Care Hospital with Special Reference to NDM and OXA Genes." International Journal of Medical and Pharmaceutical Research 4, no. 2 (2023): 264–68. https://doi.org/10.5281/zenodo.7823590.

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<strong>Background-</strong><em>Acinetobacter </em>has emerged as a nosocomial pathogen. It was sensitive to most antibiotics, but today it exhibits resistance to most first line antibiotics. Carbapenems are the drug of choice for treating this infection but now resistance to carbapenems is being reported worldwide. Antibiotic susceptibility pattern of <em>Acinetobacter</em> may vary geographically and between various units of the same hospital at various point of time. The variation in antibiogram necessitates a periodic surveillance. Hence this study was conducted to understand the differenc

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Ahmed, Sabah Mohan, and KIRAY Esin. "DETECTION AND GENETIC VARIATION OF SPA AND TST-1 GENE IN CLINICAL Staphylococcus aureus SAMPLES IN THI-QAR." EJONS International Journal on Mathematic, Engineering and Natural Sciences 7, no. 3 (2023): 393–406. https://doi.org/10.5281/zenodo.10479022.

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Urinary tract infection (UTI) is one of the most common infectious diseases in humans. Staphylococcus aureus, a gram-positive bacterium, is one of the most common causes of UTI. In this study, it was aimed to investigate the presence and genetic variation of Staphylococcal protein A (spa) and toxic shock syndrome toxin-1 (Tsst-1) gene regions by determining the distribution of S. aureus in urine samples taken from UTI patients in Thi-qar province. Various biochemical methods and API-20 and Vitek2 compact systems were used for the identification of S. aureus. Fourteen different antibiotics, whi

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McGregor, Jessina C., Yennie Quach, David T. Bearden, David H. Smith, Susan E. Sharp, and Judith A. Guzman-Cottrill. "Variation in Antibiotic Susceptibility of Uropathogens by Age Among Ambulatory Pediatric Patients." Journal of Pediatric Nursing 29, no. 2 (2014): 152–57. http://dx.doi.org/10.1016/j.pedn.2013.09.001.

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Al-Naqshbandi, Ahmed A., Hedy A. Hassan, Mahmoud A. Chawsheen, and Haval H. Abdul Qader. "Categorization of Bacterial Pathogens Present in Infected Wounds and their Antibiotic Resistance Profile Recovered from Patients Attending Rizgary Hospital-Erbil." ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 9, no. 2 (2021): 64–70. http://dx.doi.org/10.14500/aro.10864.

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Wound infection with antibiotic-resistant bacteria can extend a patients’ debility and increase the expense of treatment in the long term; therefore, careful management of patients with wound infections is necessary to avoid complications. The usage of antimicrobial agent is a major factor in resistance development. This study aims to understand the causes of wound infections, as well as the criteria for diagnosing them for more sensible antibiotic prescribing. Samples from 269 wound patients were collected, and cultured for bacterial growth. Gram stain technique, bacterial identification via

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Siddique, Arooba, Saher Mahmood, Sadia Tahir, Izna Tariq, Chaudhry Ahmed Shabbir, and Yasir Arfat. "Characterization and Prevalence of Antibiotic Resistance Staphylococcus aureus in Street Food: A Public Health Concern." TSF Journal of Biology 2, no. 2 (2024): 5–20. http://dx.doi.org/10.69547/tsfjb.020202.

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Food samples containing Staphylococcus aureus pose a serious health risk. This study aimed to examine the prevalence of S. aureus strains in various food samples sourced from Mailsi and Multan. Many food samples including yogurt, bakery products, and raw and cooked food were examined for S. aureus. The isolated strains were confirmed through Mannitol agar fermentation, catalase, coagulase, and urease tests. Hemolysis on blood agar and biofilm formation were also assessed to determine toxin production. Antibiotic sensitivity testing was conducted using the Kirby Bauer method on MH agar, and mul

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Curiao, Tânia, Emmanuela Marchi, Carlo Viti, et al. "Polymorphic Variation in Susceptibility and Metabolism of Triclosan-Resistant Mutants of Escherichia coli and Klebsiella pneumoniae Clinical Strains Obtained after Exposure to Biocides and Antibiotics." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3413–23. http://dx.doi.org/10.1128/aac.00187-15.

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ABSTRACTExposure to biocides may result in cross-resistance to other antimicrobials. Changes in biocide and antibiotic susceptibilities, metabolism, and fitness costs were studied here in biocide-selectedEscherichia coliandKlebsiella pneumoniaemutants.E. coliandK. pneumoniaemutants with various degrees of triclosan susceptibility were obtained after exposure to triclosan (TRI), benzalkonium chloride (BKC), chlorhexidine (CHX) or sodium hypochlorite (SHC), and ampicillin or ciprofloxacin. Alterations in antimicrobial susceptibility and metabolism in mutants were tested using Phenotype MicroArra

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MacGowan, Alasdair P., Rosy Reynolds, Alan R. Noel, and Karen E. Bowker. "Bacterial Strain-to-Strain Variation in Pharmacodynamic Index Magnitude, a Hitherto Unconsidered Factor in Establishing Antibiotic Clinical Breakpoints." Antimicrobial Agents and Chemotherapy 53, no. 12 (2009): 5181–84. http://dx.doi.org/10.1128/aac.00118-09.

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ABSTRACT Antibiotic pharmacodynamic modeling allows variations in pathogen susceptibility and human pharmacokinetics to be accounted for when considering antibiotic doses, potential bacterial pathogen targets for therapy, and clinical susceptibility breakpoints. Variation in the pharmacodynamic index (area-under-the-concentration curve to 24 h [AUC24]/MIC; maximum serum concentration of drug in the serum/MIC; time the serum concentration remains higher than the MIC [T > MIC]) is not usually considered. In an in vitro pharmacokinetic model of infection using a dose-ranging design, we establi

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Petrone, Federica, Carmine Gizzi, Alessandro Andriani, et al. "Investigation of Healthcare-Acquired Infections and Antimicrobial Resistance in an Italian Hematology Department before and during the COVID-19 Pandemic." Microorganisms 12, no. 7 (2024): 1296. http://dx.doi.org/10.3390/microorganisms12071296.

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Background: The COVID-19 pandemic has made antibiotic resistance (AMR) and healthcare-acquired infections (HAIs) increasingly serious problems. Point-prevalence Surveys (PPS) and other surveillance techniques are essential for antimicrobial management and prevention. Methods: In a hematology department of an Italian hospital, the prevalence of HAI, microbiology, and AMR were examined in this retrospective study in two different periods, namely 2019 and 2021 (pre-pandemic and during the pandemic, respectively). Comparisons were made between patient demographics, hospitalization duration, survei

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Needs, Sarah Helen, Sultan İlayda Dönmez, and Alexander Daniel Edwards. "Direct microfluidic antibiotic resistance testing in urine with smartphone capture: significant variation in sample matrix interference between individual human urine samples." RSC Advances 11, no. 60 (2021): 38258–63. http://dx.doi.org/10.1039/d1ra06867a.

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Alrebish, Saleh A., Nehad J. Ahmed, Hamed Al Hamed, Ajay Kumar, Hasan S. Yusufoglu, and Amer Hayat Khan. "Antibiotic Susceptibility of Bacterial Pathogens Stratified by Age in a Public Hospital in Qassim." Healthcare 10, no. 9 (2022): 1757. http://dx.doi.org/10.3390/healthcare10091757.

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Antibiotics have completely transformed medical practice by enabling the treatment of infections that were formerly fatal. However, misuse of antibiotics encourages the formation and spread of germs that are resistant to therapy, hastening the emergence of bacterial resistance. This was a retrospective study that aimed to gather information about the variation in bacterial susceptibility of various patient age groups in a public hospital in Qassim, Saudi Arabia from January 2020 to December 2021. The study included reviewing bacterial susceptibility results that were collected from the laborat

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Blanquart, François, Sonja Lehtinen, and Christophe Fraser. "An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae." Proceedings of the Royal Society B: Biological Sciences 284, no. 1855 (2017): 20170679. http://dx.doi.org/10.1098/rspb.2017.0679.

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The frequency of resistance to antibiotics in Streptococcus pneumoniae has been stable over recent decades. For example, penicillin non-susceptibility in Europe has fluctuated between 12% and 16% without any major time trend. In spite of long-term stability, resistance fluctuates over short time scales, presumably in part due to seasonal fluctuations in antibiotic prescriptions. Here, we develop a model that describes the evolution of antibiotic resistance under selection by multiple antibiotics prescribed at seasonally changing rates. This model was inspired by, and fitted to, published data

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Subedi, Kusum, Sushma Gautam, Rajeshwori Swar, Charu Arjyal, and Basista Prasad Rijal. "Seasonal Variation of Enteric Fever in Kathmandu Valley and Antibiotic Susceptibility Profile of Salmonella Enterica." Tribhuvan University Journal 36, no. 01 (2021): 18–30. http://dx.doi.org/10.3126/tuj.v36i01.43512.

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Enteric fever is of public health concern globally, more in the developing countries, which has been causing many morbidity and mortality in low- and middle-income countries. It is mostly related to poor sanitation and contaminated drinking water. This study aims to study the seasonal variation of enteric fever seen in Kathmandu valley and antimicrobial susceptibility profiles of the isolated bacteria. Therefore, blood culture of suspected patients of enteric fever was conducted from April 2018 to April 2020 using standard microbiological techniques; antimicrobial susceptibility testing was pe

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Aćimović, Milica, Lato Pezo, Ivana Čabarkapa, et al. "Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity." Processes 10, no. 8 (2022): 1608. http://dx.doi.org/10.3390/pr10081608.

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This study aimed to investigate the chemical composition of steam distillate essential oil and corresponding hydrolate obtained from S. officinalis grown in Serbia, as well as the influence of weather conditions (temperature and precipitations) on their chemical profiles. Furthermore, their antimicrobial activity was investigated in vitro. The main compounds in essential oil were cis-thujone, followed by camphor, trans-thujone, and 1,8-cineole, while hydrolate was slightly different from the essential oil, with camphor, cis-thujone, and 1,8-cineole as the main compounds. Among the eight respir

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Esposito, Silvano, Renato Gioia, Giuseppe De Simone, Silvana Noviello, and Sebastiano Leone. "BACTERIAL EPIDEMIOLOGY AND ANTIMICROBIAL RESISTANCE IN THE SURGERY WARDS OF A LARGE TEACHING HOSPITAL IN SOUTHERN ITALY." Mediterranean Journal of Hematology and Infectious Diseases 7 (May 26, 2015): e2015040. http://dx.doi.org/10.4084/mjhid.2015.040.

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Objectives: Surgical infections represent an increasingly important problem for the National Health System. In this study we retrospectively evaluated the bacterial epidemiology and antimicrobial susceptibility of the microorganisms concerned as well as the utilization of antibiotics in the General and Emergency Surgery wards of a large teaching hospital in southern Italy in the period 2011-2013.Methods: Data concerning bacterial isolates and antimicrobial susceptibility were retrieved from the Vitek II database. The pharmacy provided data about the consumption of antibiotics in the above repo

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Widerström, Micael, Marc Stegger, Anders Johansson, et al. "Heterogeneity of Staphylococcus epidermidis in prosthetic joint infections: time to reevaluate microbiological criteria?" European Journal of Clinical Microbiology & Infectious Diseases 41, no. 1 (2021): 87–97. http://dx.doi.org/10.1007/s10096-021-04352-w.

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Abstract Prosthetic joint infection (PJI) is a feared and challenging to diagnose complication after arthroplasty, with Staphylococcus epidermidis as the major pathogen. One important criteria to define PJI is the detection of phenotypically indistinguishable microorganisms with identical antibiotic susceptibility pattern in at least two different samples. However, owing to phenotypical variation within genetic clones and clonal variation within a phenotype, the criteria may be ambiguous. We investigated the extent of diversity among coagulase-negative staphylococci (CoNS) in PJI and character

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Aldridge, K. E., and C. V. Sanders. "Antibiotic- and method-dependent variation in susceptibility testing results of Bacteroides fragilis group isolates." Journal of Clinical Microbiology 25, no. 12 (1987): 2317–21. http://dx.doi.org/10.1128/jcm.25.12.2317-2321.1987.

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Vázquez, Julio A., Luisa Arreaza, Colin Block, et al. "Interlaboratory Comparison of Agar Dilution and Etest Methods for Determining the MICs of Antibiotics Used in Management of Neisseria meningitidis Infections." Antimicrobial Agents and Chemotherapy 47, no. 11 (2003): 3430–34. http://dx.doi.org/10.1128/aac.47.11.3430-3434.2003.

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ABSTRACT Previous studies have shown that there is considerable variation in the methods and media used to determine the susceptibility of Neisseria meningitidis to antimicrobial agents in different countries. In this study, national and regional reference laboratories used a standardized methodology to determine the MICs of antibiotics used in the management of meningococcal infection. Fourteen laboratories participated in the study, determining the susceptibility to penicillin G, rifampin, cefotaxime, ceftriaxone, ciprofloxacin, and ofloxacin of a collection of 17 meningococci, of which 11 s

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Jalil Abed Gatie. "INVESTIGATE OF VIRULENCE- GENES OF PASTEURELLA MULTOCIDA TYPES AND ANTIBIOTIC SUSCEPTIBILITY IN BUFFALOES IN MARSHES OF SOUTH OF IRAQ." University of Thi-Qar Journal of agricultural research 9, no. 1 (2020): 24–37. http://dx.doi.org/10.54174/utjagr.v9i1.101.

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This study was conducted to investigate the incidence of Pasteurella multocida in buffaloes in south of Iraq. A total 393 of different ages and sexes, were clinically examined. Nasal swabs and blood samples were taken . Enrich and Selective medias ,biochemical tests and Gram stain were used. also used antibiotic susceptibility. All positive cases confirmed by polymerase chain reaction with specific primer to P. multocida then use specific primers to detect P.multocida A,B. Also use specific primers to detect some virulence gene (pfhA ; nanH ; ompA ; hgbA) .Prevalence of P. multocida types in m

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Wood, Bruce W., and Charles C. Reilly. "Susceptibility of Pecan to Black Pecan Aphids." HortScience 33, no. 5 (1998): 798–801. http://dx.doi.org/10.21273/hortsci.33.5.798.

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The host-parasite interaction between the black pecan aphid (BPA) [Melanocallis caryaefoliae (Davis)] and pecan [Carya illinoensis (Wangenh.) K. Koch] was investigated. Three years of field observations of the ability of BPA populations to induce chlorotic blotches, or visual damage, on 32 pecan cultivars revealed considerable variation in cultivar susceptibility to BPA damage. Among the most commonly grown cultivars, `Sioux', `Cape Fear', `Farley', `Cowley', `Grabohls', and `Barton' exhibited the least damage, whereas `Choctaw', `Oconee', and `Sumner' exhibited the greatest, with `Sioux' and

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Vernel-Pauillac, Frédérique, and Fabrice Merien. "A Novel Real-Time Duplex PCR Assay for Detecting penA and ponA Genotypes in Neisseria gonorrhoeae: Comparison with Phenotypes Determined by the E-Test." Clinical Chemistry 52, no. 12 (2006): 2294–96. http://dx.doi.org/10.1373/clinchem.2006.075309.

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Abstract Background: For many years, the pathogenic bacterium Neisseria gonorrhoeae, the etiologic agent of gonorrhea, was generally susceptible to penicillin, until the emergence of resistant strains. Well-characterized genetic variations in the penicillin resistance–determining region correlate with decreased susceptibility to penicillin. At least 5 genes (penA, penB, mtrR, ponA, and penC) are involved in the chromosomally mediated resistance to this antibiotic. To date, no development of multiplex PCR assays targeting a range of gonococcal genes and variations as a means of predicting antib

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Vaz-Moreira, Ivone, Olga C. Nunes, and Célia M. Manaia. "Diversity and Antibiotic Resistance Patterns of Sphingomonadaceae Isolates from Drinking Water." Applied and Environmental Microbiology 77, no. 16 (2011): 5697–706. http://dx.doi.org/10.1128/aem.00579-11.

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ABSTRACTSphingomonadaceae(n= 86) were isolated from a drinking water treatment plant (n= 6), tap water (n= 55), cup fillers for dental chairs (n= 21), and a water demineralization filter (n= 4). The bacterial isolates were identified based on analysis of the 16S rRNA gene sequence, and intraspecies variation was assessed on the basis ofatpDgene sequence analysis. The isolates were identified as members of the generaSphingomonas(n= 27),Sphingobium(n= 28),Novosphingobium(n= 12),Sphingopyxis(n= 7), andBlastomonas(n= 12). The patterns of susceptibility to five classes of antibiotics were analyzed

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Kadri, Sameer S., Yi Ling Lai, Emily Ricotta, et al. "Epidemiology of Inappropriate Empiric Antibiotic Therapy for Bacteremia Based on Discordant In vitro Susceptibilities: Risk factors and Taxon-level Variation in Burden and Outcome in 156 US hospitals, 2000–2014." Open Forum Infectious Diseases 4, suppl_1 (2017): S13—S14. http://dx.doi.org/10.1093/ofid/ofx162.032.

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Abstract Background Discordance between in vitro susceptibility and empiric antibiotic therapy is inextricably linked to antibiotic resistance and decreased survival in bloodstream infections (BSI). However, its prevalence, patient- and hospital-level risk factors, and impact on outcome in a large cohort and across different pathogens remain unclear. Methods We examined in vitro susceptibility interpretations for bacterial BSI and corresponding antibiotic therapy among inpatient encounters across 156 hospitals from 2000 to 2014 in the Cerner Healthfacts database. Discordance was defined as non

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Rojas, Laura J., Steven Marshall, Mohamad Yasmin, et al. "234. Reversal of Carbapenem and Amikacin Susceptibilities in Isogenic Klebsiella pneumoniae From a Patient with Persistent Bacteriuria." Open Forum Infectious Diseases 6, Supplement_2 (2019): S134. http://dx.doi.org/10.1093/ofid/ofz360.309.

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Abstract Background Genomic tools permit a detailed analysis of antibiotic resistance determinants in bacteria, or resistome. Here we discuss variations in antibiotic resistance in K. pneumoniae (Kp) not explained by changes in the resistome Methods We compared Kp strains with divergent carbapenem and aminoglycoside susceptibilities. After identification of bacteria, antibiotic susceptibility testing was performed according to CLSI guidelines. Draft genome sequences were generated using Illumina MiSeq (Nextera paired-end library) and assembled using CLC Genomics Workbench (CLC bio, Cambridge,

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Nikolaisen, Nanett Kvist, Mette Fertner, Desiree Corvera Kløve Lassen, et al. "Association between Antibiotic Consumption and Resistance in Mink Production." Antibiotics 11, no. 7 (2022): 927. http://dx.doi.org/10.3390/antibiotics11070927.

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Antibiotic consumption is considered to be a main driver of antibiotic resistant bacteria. Mink breeding follows a distinctive seasonal reproduction cycle, and all of the mink produced in the northern hemisphere are bred, born, and pelted around the same time of year. Some of the diseases are age-related, which is reflected in the seasonal variation of antibiotic consumption. The seasonality makes mink a good model for the investigation of the association between antibiotic consumption and resistance. The objectives of this study were (1) to monitor the farm level of antibiotic resistance duri

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Australian Gonococcal Surveillance Programme and John Tapsall. "Annual report of the Australian Gonococcal Surveillance Programme 1996." Communicable Diseases Intelligence 21 (July 10, 1997): 189–92. https://doi.org/10.33321/cdi.1997.21.39.

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In 1996 the Australian Gonococcal Surveillance Programme (AGSP) examined 2,753 isolates of Neisseria gonorrhoeae. The source of isolates, site of infection and antibiotic susceptibility patterns showed considerable regional variation. Strains examined in Adelaide, Sydney and Melbourne were predominantly from male patients where rectal and pharyngeal isolates were common. Cases in other centres had a much lower male:female ratio and most were genital tract isolates. Resistance to the penicillin and quinolone groups of antibiotics was highest in Sydney and Melbourne. Gonococcal resistance to the

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Thulin, Sara, Per Olcén, Hans Fredlund та Magnus Unemo. "Total Variation in the penA Gene of Neisseria meningitidis: Correlation between Susceptibility to β-Lactam Antibiotics and penA Gene Heterogeneity". Antimicrobial Agents and Chemotherapy 50, № 10 (2006): 3317–24. http://dx.doi.org/10.1128/aac.00353-06.

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ABSTRACT In recent decades, the prevalence of Neisseria meningitidis isolates with reduced susceptibility to penicillins has increased. The intermediate resistance to penicillin (Peni) for most strains is due mainly to mosaic structures in the penA gene, encoding penicillin-binding protein 2. In this study, susceptibility to β-lactam antibiotics was determined for 60 Swedish clinical N. meningitidis isolates and 19 reference strains. The penA gene was sequenced and compared to 237 penA sequences from GenBank in order to explore the total identified variation of penA. The divergent mosaic allel

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Rahmati-Bahram, A., J. T. Magee, and S. K. Jackson. "Growth temperature-dependent variation of cell envelope lipids and antibiotic susceptibility in Stenotrophomonas (Xanthomonas) maltophilia." Journal of Antimicrobial Chemotherapy 36, no. 2 (1995): 317–26. http://dx.doi.org/10.1093/jac/36.2.317.

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Gupta, Gunjan, Vibhor Tak та Purva Mathur. "Detection of AmpC β Lactamases in Gram-negative Bacteria". Journal of Laboratory Physicians 6, № 01 (2014): 001–6. http://dx.doi.org/10.4103/0974-2727.129082.

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ABSTRACT AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, and β-lactamase inhibitor/β-lactam combinations. The increase in antibiotic resistance among Gram-negative bacteria is a notable example of how bacteria can procure, maintain and express new genetic information that can confer resistance to one or several antibiotics. Detection of organisms producing these enzymes can be difficult, because their presence does n

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Stuart, J. M., P. M. Robinson, K. Cartwright, and N. D. Noah. "Antibiotic prescribing during an outbreak of meningococcal disease." Epidemiology and Infection 117, no. 1 (1996): 103–5. http://dx.doi.org/10.1017/s0950268800001187.

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SummaryDuring a prolonged outbreak of meningococcal disease caused by serogroup B serotype 15 sulphonamide-resistant strains in one British health district, there was considerable variation in attack rates by town. General practitioner (GP) antibiotic prescribing rates were compared in high and low incidence towns. The only significant difference found was that erythromycin prescribing was more frequent in the high incidence towns (rate ratio 4·0, 95% CI 3·2–4·8, in March 1987 and 3·0, 95% CI 2·4–3·7, in November 1987). This was probably due to increased GP consultation rates for upper respira

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St. Cyr, Sancta, Laura Quilter, Cau D. Pham, Elizabeth Torrone, and Hillard Weinstock. "434. Concurrent Gonococcal Infections with Differing Susceptibility Results from the Enhanced Gonococcal Isolate Surveillance Project (eGISP)." Open Forum Infectious Diseases 6, Supplement_2 (2019): S216. http://dx.doi.org/10.1093/ofid/ofz360.507.

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Abstract Background Concurrent gonococcal infections could impact treatment success in cases of anatomic site-specific strains with different antimicrobial susceptibilities; however, little is known about same-patient differences in susceptibility as most antibiotic resistance surveillance is based on only male urethral isolates. Methods In August 2017, the enhanced Gonococcal Isolate Surveillance Project (eGISP) began collecting male and female genital and extragenital gonococcal isolates from patients in 12 STD clinics. Minimum Inhibitory Concentrations (MICs) for penicillin, tetracycline, c

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Mutlu, Esvet, Allison J. Wroe, Karla Sanchez-Hurtado, Jon S. Brazier, and Ian R. Poxton. "Molecular characterization and antimicrobial susceptibility patterns of Clostridium difficile strains isolated from hospitals in south-east Scotland." Journal of Medical Microbiology 56, no. 7 (2007): 921–29. http://dx.doi.org/10.1099/jmm.0.47176-0.

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Clostridium difficile isolates (n=149) collected in south-east Scotland between August and October 2005 were typed by four different methods and their susceptibility to seven different antibiotics was determined. The aims were to define the types of strain occurring in this region and to determine whether there were any clonal relationships among them with respect to genotype and antibiotic resistance pattern. Ribotyping revealed that 001 was the most common type (n=113, 75.8 %), followed by ribotype 106 (12 isolates, 8.1 %). The majority of the isolates (96.6 %, n=144) were of toxinotype 0, w

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Xiong, Huizhong, Rebecca A. Carter, Ingrid M. Leiner, et al. "Distinct Contributions of Neutrophils and CCR2+Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains." Infection and Immunity 83, no. 9 (2015): 3418–27. http://dx.doi.org/10.1128/iai.00678-15.

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Klebsiella pneumoniaeis a common respiratory pathogen, with some strains having developed broad resistance to clinically available antibiotics. Humans can become infected with many differentK. pneumoniaestrains that vary in genetic background, antibiotic susceptibility, capsule composition, and mucoid phenotype. Genome comparisons have revealed differences betweenK. pneumoniaestrains, but the impact of genomic variability on immune-mediated clearance of pneumonia remains unclear. Experimental studies of pneumonia in mice have used the rodent-adapted 43816 strain ofK. pneumoniaeand demonstrated

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