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1

Centers for Disease Control and Prevention (U.S.), ed. Careful antibiotic use: The emerging threat of antibiotic resistance. Centers for Disease Control and Prevention, 2000.

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2

Centers for Disease Control and Prevention (U.S.), ed. Careful antibiotic use: The emerging threat of antibiotic resistance. Centers for Disease Control and Prevention, 2000.

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3

Centers for Disease Control and Prevention (U.S.), ed. Careful antibiotic use: The emerging threat of antibiotic resistance. Centers for Disease Control and Prevention, 2000.

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4

Centers for Disease Control and Prevention (U.S.), ed. Careful antibiotic use: Stemming the tide of antibiotic resistance : recommendations by the CDC/AAP to promote antibiotic use. Centers for Disease Control and Prevention, 2000.

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5

F, Galley Helen, and Intensive Care Society (Great Britain)., eds. Antibiotic resistance and infection control. BMJ Books, 2001.

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6

Duff, W. Patrick. Antibiotic use in obstetrics and gynecology. W.B. Saunders Co., 1992.

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7

Bonilla, Adriel R. Antibiotic resistance: Causes and risk factors, mechanisms and alternatives. Nova Science Publishers, 2009.

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8

III, Arch G. Mainous. Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance. 2nd ed. Humana Press, 2010.

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9

United States. Congress. House. Committee on Rules, ed. Antibiotic resistance: Agencies have made limited progress addressing antibiotic use in animals : report to the Ranking Member, Committee on Rules, House of Representatives. U.S. Govt. Accountability Office, 2011.

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10

Office, General Accounting. Antibiotic resistance: Federal agencies need to better focus efforts to address risk to humans from antibotics use in animals : report to congressional requesters. United States General Accounting Office, 2004.

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11

Health, United States Congress House Committee on Energy and Commerce Subcommittee on. Antibiotic resistance and the use of antibiotics in animal agriculture: Hearing before the Subcommittee on Health of the Committee on Energy and Commerce, House of Representatives, One Hundred Eleventh Congress, second session, July 14, 2010. U.S. G.P.O., 2013.

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12

Thomas, Ann R. Judicious use of antibiotics: A guide for Oregon clinicians. 2nd ed. Oregon AWARE, 2007.

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13

Dr, McKenna John, ed. Natural alternatives to antibiotics. Avery Pub. Group, 1998.

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14

Buhner, Stephen Harrod. Herbal antibiotics. 2nd ed. Storey Pub., 2012.

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15

Coates, Anthony R. M., ed. Antibiotic Resistance. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28951-4.

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16

United States. Food and Drug Administration. Office of Women's Health., ed. Antibiotic resistance. FDA Office of Women's Health, 2007.

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17

United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health. Promoting the development of antibiotics and ensuring judicious use in humans: Hearing before the Subcommittee on Health of the Committee on Energy and Commerce, House of Representatives, One Hundred Eleventh Congress, second session, June 9, 2010. U.S. G.P.O., 2012.

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18

Gillespie, Stephen H., and Timothy D. McHugh, eds. Antibiotic Resistance Protocols. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-279-7.

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19

Gillespie, Stephen H., ed. Antibiotic Resistance Protocols. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7638-6.

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20

Gillespie, Stephen H., ed. Antibiotic Resistance Protocols. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3981-8.

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21

Gould, Ian M., and Jos WM van der Meer, eds. Antibiotic Policies: Fighting Resistance. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-70841-6.

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22

Sköld, Ola. Antibiotics and Antibiotic Resistance. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075609.

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23

Jones, Cindy L. A. האלטרנטיבה לאנטיביוטיקה: Ha-madrikh ha-ṭivʻi la-milḥamah be-zihumim u-shemirah ʻal maʻarekhet ḥisun beriʼah. Aḥ, 2008.

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24

Gillespie, Stephen H. Antibiotic Resistance Methods and Protocols. Humana Press, 2000. http://dx.doi.org/10.1385/1592590772.

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25

Singh, Om V., ed. Foodborne Pathogens and Antibiotic Resistance. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119139188.

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26

Manaia, Célia M., Erica Donner, Ivone Vaz-Moreira, and Peiying Hong, eds. Antibiotic Resistance in the Environment. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55065-3.

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27

Klein, Eili Y. Antibiotic Resistance. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0068.

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Antibacterial resistance threatens the ability of physicians to treat infections, reversing medical gains and increasing the probability of morbidity and mortality in infected patients. Decreased antibiotic efficacy also threatens advanced surgical procedures dependent on antibiotic effectiveness, such as organ and prosthetic transplants. Even simple procedures consider antibiotic prophylaxis to be a standard means of controlling surgical site infections. Despite the link between increased antibiotic use and resistance, a large fraction of antimicrobial use is inappropriate, particularly for a
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28

Coates, Anthony R. M. Antibiotic Resistance. Springer London, Limited, 2012.

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29

Coates, Anthony R. M. Antibiotic Resistance. Springer Berlin / Heidelberg, 2014.

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30

Antibiotic resistance protocols. 2nd ed. Humana Press, 2010.

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31

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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32

Hughes, D., Diarmaid Hughes, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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33

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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34

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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35

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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36

Hughes, Diarmaid, and Dan I. Andersson. Antibiotic Development and Resistance. Taylor & Francis Group, 2001.

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37

Careful antibiotic use: Stemming the tide of antibiotic resistance : recommendations by the CDC/AAP to promote antibiotic use. Centers for Disease Control and Prevention, 2000.

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38

Antibiotic resistance: Methods and protocols. Humana Press, 2001.

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39

Careful antibiotic use: Stemming the tide of antibiotic resistance : recommendations by the CDC/AAP to promote antibiotic use. Centers for Disease Control and Prevention, 2000.

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40

Soulsby, Lord. Antimicrobial resistance: animal use of antibiotics. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0005.

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The evolution of resistance to microbes is one of the most significant problems in modern medicine, posing serious threats to human and animal health. The early work on the use of antibiotics to bacterial infections gave much hope that infectious diseases were no longer a problem, especially in the human field. However, as their use, indeed over use, progressed, resistance (both mono-resistance and multi-resistance), which was often transferable between different strains and species of bacteria, emerged. In addition, the situation is increasingly complex, as various mechanisms of resistance, i
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41

Edgeworth, Jonathan. Antibiotic resistance in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0289.

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The two objectives of ensuring early appropriate antimicrobial treatment for septic patients on the intensive care unit (ICU), and limiting emergence and spread of antimicrobial resistance are both complicated and potentially conflicting. Increasingly unpredictable resistance, particularly amongst Gram-negative bacteria, through both local selection and transmission, and importation of globally successful resistant clones encourages the use of broad-spectrum empiric antimicrobials for septic patients, including in combination. This may lead to a vicious cycle whereby increasing antibiotic use
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42

Antibiotic resistance: Causes and risk factors, mechanisms and alternatives. Nova Science Publishers, 2009.

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43

Firth, Clair L., ed. Monitoring and Surveillance of Veterinary Antimicrobial Use and Antibiotic Resistance in Animals. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4081-8.

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44

Burke, D. C. Use of Antibiotic Resistance Markers in Genetically Modified Plants for Human Food. Diane Pub Co, 1996.

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45

Hopkins, Susan. The international and national challenges faced in ensuring prudent use of antibiotics. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198758792.003.0001.

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In April 2014, the World Health Organization reinforced that without urgent coordinated action by most stakeholders the world is headed for a post-antibiotic era in which common infections and minor injuries, which have been treatable for decades, could kill once again. With the rise in the number of infections due to antibiotic-resistant bacteria and the lack of development of new antibiotics, antimicrobial resistance is a major clinical and public health issue that society needs to tackle. This chapter focuses on the challenges of drug resistance and antimicrobial development together with h
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46

Enzybiotics: Antibiotic enzymes as drugs and therapeutics. John Wiley & Sons, 2010.

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47

III, Arch G. Mainous, and Claire Pomeroy. Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance. Humana, 2012.

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48

III, Arch G. Mainous, and Claire Pomeroy. Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance. Humana Press, 2011.

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49

Arch G. Mainous III (Editor) and Claire Pomeroy (Editor), eds. Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance (Infectious Disease). Humana Press, 2001.

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50

U. S. Government Accountability Offi Gao. Antibiotic Resistance: More Information Needed to Oversee Use of Medically Important Drugs in Food Animals. Independently Published, 2019.

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