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Dissertations / Theses on the topic 'Antibiotic use and resistance'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Enne, Virve Irene. "Sulphonamide resistance and its relationship to sulphonamide use." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268766.

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2

Norgren, Benjamin. "What role does aquaculture play in the global rise of antibiotic-resistant bacteria?" Thesis, Stockholms universitet, Institutionen för ekologi, miljö och botanik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-182602.

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In a world where the human population is increasing, new innovations to produce enough food are required. Aquaculture’s part of the global animal protein production has increased in recent years and could be a possible solution. However, if aquaculture is poorly managed, it can result in negative consequences and one such consequence is the development of antibiotic resistance. In this review, I examine how aquaculture affect antibiotic resistance by studying what the literature says on accumulation of antibiotics in different organisms and sediment, if antibiotics can be transferred to humans

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3

Mohrs, Simone. "Factors influencing the use of antibiotics and knowledge about antibiotic resistance in Jakarta : A qualitative study on the perceptions of stakeholders involved in Yayasan Orangtua Peduli’s Smart Use of Antibiotics campaign in Indonesia." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303379.

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Introduction: Southeast Asia has among the highest rates of antibiotic resistance worldwide, particularly in Indonesia, where paediatricians prescribed antibiotics to 94% of children, knowing that the infection was viral. Relevance: There is a gap in understanding of the reasons behind the irrational use of antibiotics by healthcare professionals and patients. Aim: This research aims to explore factors that influence the use of antibiotics and knowledge about antibiotic resistance in Jakarta, Indonesia. Methods: In December 2014, the researcher conducted thirteen semi-structured interviews wit

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4

Zawahir, Mohamed Shukry. "Pharmacists’ provision and public’s use of antibiotics for common infections in Sri Lanka." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21779.

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Background: Antibiotic resistance (ABR) is a major and complex preventable global problem which transcends international boundaries. It makes infections more difficult to treat or even untreatable as well as contributing to a shrinking range of effective antibiotics available. Transmission of bacteria which are resistant to antibiotics between developed and developing countries is two-way, however it has been rarely explored in developing countries because of inadequate resources. There is evidence suggesting that the emergence and spread of ABR, especially the appearance of multidrug-resistan

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5

Larsson, Mattias. "Antibiotic use and resistance : assessing and improving utilisation and provision of antibiotics and other drugs in Vietnam /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-630-8/.

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6

Thompson, Mellisa. "Antibiotic Prescribing Habits of Urgent Care Providers." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5791.

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Antibiotics are commonly prescribed and requested for viral illnesses despite evidence-based research studies and societal guidelines that advise against this practice. Literature has indicated that antibiotic decision-making comes from a provider's experience or exposure to illness, uncertainty of illness, or from being pressured by the patient. Nurses and advanced practice nurses are important participants in the antibiotic stewardship initiative. The purpose of this project was to examine potential knowledge deficits responsible for inappropriate antibiotic prescribing at a rural urgent car

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7

Ansari, Faranak. "Evaluation and management of hospital antibiotic use." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/917390eb-a8ea-477a-8cc8-58b6babac813.

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Antimicrobials are unique drugs in that they target "infectious" or "transferable" diseases. There is considerable evidence linking increasing antimicrobial use withincreasing resistance. Resistant bacteria do not know the boundaries, either between countries or within a society between hospital and primary care. Inappropriate prescribing of antimicrobials in hospitals therefore has consequences for whole communities and problems may spread both nationally and internationally. The gathering of reliable measurements of antibiotic use in hospitals employing standardised methods is essential to b

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8

Ibrahim, Mohamad. "Evaluation of antibiotic use in a Lebanese hospital." Thesis, Cranfield University, 2016. http://dspace.lib.cranfield.ac.uk/handle/1826/10012.

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Antimicrobial resistance is a significant global health problem. Misuse of antibiotics is associated with antimicrobial resistance which presents clinicians with treatment challenges and increases the complexity of the decision making process related to the selection of appropriate antibiotic therapy. Antibiotic resistant organisms can often lead to nosocomial infections (NIs) and undoubtedly causes patient harm and increases healthcare costs. According to the National Institute of Allergy and Infectious Diseases (NIAID), at least 70% of the nosocomial infections are caused by antibiotic-resis

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9

Sahoo, Krushna Chandra. "Antibiotic use, environment and antibiotic resistance : A qualitative study among human and veterinary health care professionals in Orissa, India." Thesis, Halmstad University, School of Business and Engineering (SET), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-1877.

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<p>Objective: To explore views of medical doctors, veterinarians and drug sellers on use of antibiotics on humans and nonhumans and on factors that influences the development of resistance to antibacterial agents. Further, to look at the bi-directional relationship between antibiotic use and environment. </p><p>Methods: The study was a qualitative explorative interview study, analysed using conventional content analysis. It was conducted in Orissa, India. Data were collected by face to face semi structured interview. The interviews were tape recorded and transcribed into Oriya, then translated

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10

Farley, Elise. "Knowledge, attitudes and perceptions of antibiotic use and antibiotic resistance among private sector patients and prescribers in South Africa." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27431.

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Antibiotic resistance (ABR), alternately referred to as antimicrobial resistance, has been labelled as the next big global health crisis. If current levels of ABR continue along the same trajectories, by 2050 ABR will cost the lives of 10 million people a year, ABR cannot be stopped but it can be slowed down. ABR occurs because the bacteria evolve to protect themselves from antibiotics. One of the main causes of ABR is the misuse and over prescription of antibiotics. The primary objective of the study is to ascertain the level of knowledge, attitudes and perceptions of appropriate antibiotic u

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11

TITTARELLI, CRISTIANA. "MYCOBACTERIOSIS IN WILD BOARS: STUDY FOR THE USE OFLIQUID MEDIA AND ANTIBIOTIC RESISTANCE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232416.

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A retrospective study (2004-2010) on 24 Mycobacterium bovis strains isolated from wild boars (Sus scrofa) (n=18) and cattle (n=6) in Imperia province (Savona province has been included in the study just in 2006) was performed to detect the prevalence and distribution of antibiotic-resistant strains. Actually, in this area cases of M. bovis infections in wild boar were related to cases in cattle herds due to the overlapping of their respective habitat and pasture areas, suggesting the role of these animals as bio-indicator of the presence of M. bovis in the environment and, in consequence, in f

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12

Lum, Elaine P. M. "Making decisions about antibiotic use in the Australian primary healthcare sector." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/107540/1/Elaine_Lum_Thesis.pdf.

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Antibiotic use drives antibiotic resistance, a global issue with significant human health and economic burden. Australia’s antibiotic consumption is above the OECD average. However, it is unclear which factors are most important for driving antibiotic use in Australian primary healthcare. This research established the most important factors influencing general practitioners to prescribe antibiotics and consumers to use antibiotics. In addition, a model was developed — the Enabling Antibiotic Eupraxis (EABE) model — to explain the drivers of antibiotic use from three perspectives: general prac

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13

Schneider-Lindner, Verena. "Antibiotic use in children: Assessing the risk of methicillin resistance using different study designs." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106318.

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Children have generally received a considerable number of outpatient antibacterial prescriptions, but recent trends in utilization are unknown. Concurrently, resistance to methicillin has been increasingly reported for infections with Staphylococcus aureus in the community, but an association with antibacterials has not been shown for children. In assessing this association, within-subject study designs such as the case-time-control can control exposure time trends in addition to unmeasured and unmeasurable stable confounders. The efficiency of such analyses has not yet been assessed for match

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14

Pankow, Christine Ann. "Effect of Soil Type, Composting, and Antibiotic Use on Fate of Antibiotic Resistance Genes and Microbial Community Composition in Dairy and Beef Manure Applied Soils." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86672.

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Manure is a commonly used soil fertilizer, but there are concerns that this practice could affect the spread of antibiotic resistance genes (ARGs) from farm to fork. A microcosm-scale study evaluated the effect of prior antibiotic use (manure-based soil amendments generated from dairy and beef cattle with or without antibiotic administration), composting, and soil type on the quantity of ARGs and the microbial community composition of dairy and beef manure applied soil. ARGs were analyzed through novel metagenomic techniques and quantitative polymerase chain reaction of sul1, tet(W), and 16S r

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15

Kristiansson, Charlotte. "Access to health care for children in Amazonian Peru focus on antibiotic use and resistance /." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-616-3/.

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16

Jeong, Dahn. "The Use of Antibiotics in the Treatment of Skin and Soft Tissue Infections in Selected Canadian First Nations Communities." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32178.

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Methicillin-resistant Staphylococcus aureus (MRSA) is a growing concern in Canada especially in Aboriginal communities in remote regions. The northern and remote communities possess some or many of the risk factors that are identified in previous research to be associated with Community-Associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) infections such as overcrowding, challenges in maintaining personal hygiene and limited access to healthcare. CA-MRSA spreads rapidly in the communities. It is known to not only affect young and healthy individuals, but it is also associated with

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17

Tatavarthy, Aparna. "Molecular Subtyping and Antibiotic Resistance Analysis of Salmonella Species." [Tampa, Fla] : University of South Florida, 2005. http://purl.fcla.edu/usf/dc/et/SFE0001307.

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18

Alumran, Arwa Khalid O. "Assessment of antibiotic use in children by their parents in Saudi Arabia." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/72627/4/Arwa_Khalid_O_Alumran_Thesis.pdf.

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This project assessed the factors influencing the parents' use of antibiotics in children in Saudi Arabia. It was conducted through the development and validation of the Parental Perceptions on Antibiotics (PAPA) Scales, which is the first valid and reliable instrument directed to measure these factors on a population-based level. This is also the first population-based study that measures the patterns of antibiotic use in children in Saudi Arabia, where a very high association was found between the use of antibiotics and the number of cold episodes a year, which suggests a potential of overus

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19

Kyu, Pye. "Antibiotic Use by Members of the American Association of Endodontics: A National Survey for 2009- A Follow up from the Report in 1999." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/2006.

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The purpose of this study was to determine the changes in prescribing habits of active members of American Association of Endodontics (AAE) with regards to antibiotics in comparison to the findings reported by Yingling et al. in 1999. The invitations to take the online survey were sent via email to 2593 active members. A response rate of 37.75% was obtained. It was determined to be adequate for analysis and for comparison to the results obtained by Yingling et al. Comparisons between the percentages shown in this survey and the previous survey were tested using a z-test. An ANOVA model was us

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20

Christian, Kristi Lynn. "The relationship between the level of antibiotic use and resistance among enteric bacteria in a multi-site integrated human and swine population." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2738.

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21

Carter, Rebecca Rosaly Carter. "ANTIBIOTIC STEWARDSHIP IN AMERICAN NURSING HOMES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1538588980802258.

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22

Gramming, Helene, and Molly Hammar. "Människors attityder och beteende gällande antibiotikaanvändning utifrån ett antibiotikaresistent perspektiv – en enkätstudie." Thesis, Högskolan i Skövde, Institutionen för hälsovetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20133.

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Introduktion: Antibiotikaresistens är idag ett av de största globala hoten mot folkhälsan. Antibiotikaresistens innebär att bakterier blir resistenta mot läkemedlet antibiotika, vilket leder till att sjukdomar som tidigare varit behandlingsbara med antibiotika blir svårbehandlade eller icke behandlingsbara. Detta leder i sin tur till högre dödlighet, längre sjukhusvistelser samt en högre kostnad för vården. Resistensen sker även naturligt men det är tydligt att överanvändning och missbrukning av antibiotikan skyndar på resistensutvecklingen avsevärt. Syfte: Syftet med den här studien är att un

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23

Willms, Inka [Verfasser]. "Assessment of antibiotic resistance in soil and its link to different land use types and intensities / Inka Willms." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1213974968/34.

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24

Christofilogiannis, Panagiotis. "Use of antibiotics in Greek mariculture." Thesis, University of Stirling, 2002. http://hdl.handle.net/1893/3250.

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Bacteriological survey of the fish pathogens in Greek mariculture between 1994- 1997 was followed by analysis of prevalence in sea bass, sea bream, sharpsnout bream and common Dentex and discussion of the impact of various fish pathogens. In addition antibiotic resistance profiles and frequencies were studied using quantitative antibiogram and MIC analysis for the two most commonly used antibiotics Oxolinic acid and Oxytetracycline and clinically relevant MIC breakpoints were extrapolated for different fish species and main fish pathogens. The kinetics of the above antimicrobials were analysed

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25

Wade, Timothy Rion. "Use of Escherichia coli for Microbial Source Tracking in a Mixed Use Watershed in Northern Virginia." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/35339.

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Prince William County, located in the rapidly developing Northern Virginia region, contains watersheds of mixed rural and urban/suburban uses. The project goal was to monitor and evaluate 21 stream locations, over 13 months, in the Occoquan Basin identified as impaired due to high E. coli densities. One site on each of eight streams, two sites on each of five streams, and three sites on the remaining stream were chosen for E. coli monitoring and microbial source tracking (MST). MST was performed using antibiotic resistance analysis (ARA) and fluorometric analysis. Escherichia coli was cho

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26

Knox, Natalie. "An exploration of ecological concepts in the context of antimicrobial resistance and the use of phytochemical compounds within the ruminant gut microbiome." Agricultural Institute of Canada, publisher of Canadian Journal of Plant Science, 2008. http://hdl.handle.net/1993/14405.

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Secondary plant metabolites have recently been gaining interest in livestock production systems following the ban of in-feed antibiotics within the European Union. The rise in antimicrobial resistance found in pathogenic and non-pathogenic bacteria has lead to increased interest in the research community regarding the use of phythochemicals as an alternative to antibiotics. The purpose of this research was to evaluate the impact of including phytochemicals in a livestock production system. Specifically, a high tannin-containing forage, sainfoin (Onobrychis viciifolia), was evaluated in vitro f

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Berge, Anna Catharina Björnsdotter. "Spatial, temporal and management-specific factors influencing antibiotic resistance and carbohydrate fermentation patterns in bovine enteric Escherichia coli and the clinical consequences of limiting antibiotic use in pre-weaned calves /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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Thesis (Ph. D.)--University of California, Davis, 2004.<br>Degree granted in Comparative Pathology. Library does not have original title page. Also available via the World Wide Web. (Restricted to UC campuses)

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Kim, Jeffrey. "Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460912847.

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Denholm, Rachael Ann. "Changes in Antimicrobial Resistance from 1994 to 2011 and Exploring Farm Management Practices Associated with Antimicrobial Resistance in Salmonella on U.S. Beef Feedlots." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492702064126336.

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30

Krige, Marilyn. "Molecular investigation of the chlorine and antibiotic resistance mechanisms of Escherichia coli isolated from natural water sources in the Western Cape." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2779.

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Thesis (MScMedSc (Pathology. Medical Microbiology))--University of Stellenbosch, 2009.<br>Water is used for various purposes and contamination can have severe implications if untreated. One of the most common and cost effective water disinfectants, especially used in developing countries, is chlorine. However, microorganisms have developed different mechanisms in response to environmental stress conditions, such as the viable but nonculturable (VBNC) effects possibly displayed in this study, enabling them to survive. Chlorine may also exert several effects on microorganisms, such as the e

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31

Kolar, Stephanie. "Laboratory analysis of Staphylococcus aureus in Florida from January 1, 2003 to December 31, 2005 with an emphasis on methicillin resistance." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001784.

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Brilhante, Vânia Cristina Ribeiro. "Avaliação do grau de conhecimento dos princípios básicos de antibioticoterapia de médicos que atuam em urgência e emergência no Estado do Pará." Universidade Federal do Amazonas - Universidade Federal do Pará, 2011. http://tede.ufam.edu.br/handle/tede/4521.

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Submitted by Geyciane Santos (geyciane_thamires@hotmail.com) on 2015-07-29T13:47:39Z No. of bitstreams: 1 Dissertação - Vânia Cristina Ribeiro Brilhante.pdf: 447163 bytes, checksum: 5374102907554be85557bd94f255ce52 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2015-07-29T19:31:52Z (GMT) No. of bitstreams: 1 Dissertação - Vânia Cristina Ribeiro Brilhante.pdf: 447163 bytes, checksum: 5374102907554be85557bd94f255ce52 (MD5)<br>Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2

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Tello, Gildemeister Alfredo. "A study into the effects and environmental risk of antibiotics used in freshwater aquaculture on environmental bacteria." Thesis, University of Stirling, 2012. http://hdl.handle.net/1893/9930.

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Aquaculture is the fastest growing food industry in the world and it accounts for roughly half of the world's fish supply. The majority of global aquaculture production occurs in freshwater systems that are increasingly subject to multiple uses by different stakeholders. Given the overall scarcity of freshwater on a global scale, freshwater aquaculture will face increasing environmental constraints that will demand an ever better understanding of its potential impacts on the aquatic environment and human health. This thesis consists of a series of studies that, collectively, contribute to furt

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34

Bociek, Karol. "Use of Tn5-transposon mutagenesis for the identification of potential novel interactors of antimicrobial peptides in E.coli." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3619.

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2008/2009<br>Antimicrobial peptides (AMPs) participate in the immunity of both animals and plants. In mammals, the most important AMP families are defensins and cathelicidins. The only human cathelicidin, LL-37, is a 37-residue, α-helical, cationic peptide with a direct membranolytic antibacterial activity and various immunomodulatory activities. The aim of our research was to establish a procedure based on an E. coli knock-out mutant library in the search for mutations conferring altered susceptibility to AMPs. The library was created by random insertions of Tn5 transposon into the bacterial

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Clem, Angela. "Bacteriophage for the elimination of methicillin-resistant staphylococcus aureus (MRSA) colonization and infection." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001568.

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Fatoumata, Diarrassouba. "Impacts of antimicrobial growth promoters used in broiler chicken production on the emergence of antibiotic resistance in commensal E. coli and Salmonella." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1614.

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Despite their beneficial effects, concerns have been raised about the role of antimicrobial growth promoters (AGP) in the emergence of antibiotic resistant bacteria. This study evaluated the effects of approved AGP on the emergence of antibiotic resistance in commensal E. coli and foodborne pathogen Salmonella. A survey of antibiotic resistance levels in commercial broiler chicken farms in the Fraser Valley (B.C.) and an experimental feeding trial were conducted from May 2004 to February 2005 and May to November 2005, respectively. The latter examined the effects of ten AGP formulations (bambe

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Long, Timothy E. (Timothy Edward). "N-thiolated &esc;gb&esc;s-lactams [electronic resource] : chemistry and biology of a novel class of antimicrobial agents for MRSA / by Timothy E. Long." University of South Florida, 2003.

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Includes vita.<br>Title from PDF of title page.<br>Document formatted into pages; contains 173 pages.<br>Thesis (Ph.D.)--University of South Florida, 2003.<br>Includes bibliographical references.<br>Text (Electronic thesis) in PDF format.<br>ABSTRACT: N-Methylthio beta-lactams represent a promising new family of antibacterial agents whose in vitro activity is confined largely to Staphylococcus species, including multidrug-resistant forms of S. aureus. Originally developed in the 1980's for use as synthetic intermediates, N-methylthio beta-lactams have recently been shown in these laboratories

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Drennon, Michael T. "Drug resistant patterns of invasive Streptococcus pneumoniae infections in the State of Florida in 2003." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001455.

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Hawkings, Nancy J. "Attitudes to upper respiratory infections, antibiotics and bacterial resistance : managing common respiratory infections and promoting the appropriate use of antibiotics by the general population." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55173/.

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The public, as the users of antibiotics, can contribute to the control of bacterial resistance. National and international campaigns have recommended public education to promote the judicious and safe use of antibiotics, and in particular, reducing antibiotic use and misuse in upper respiratory tract infections. Campaigns, however, have not been informed by detailed understanding of public attitudes to the problem. Although previous studies have explored lay perceptions of common infections and antibiotics, public attitudes to bacterial resistance, beliefs about antibiotic use in relation to b

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Anderson, Matthew A. (Matthew Alexander). "Frequency distributions of Escherichia coli subtypes in various fecal sources over time and geographical space [electronic resource] : application to bacterial source tracking methods / by Matthew A. Anderson." University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000206.

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Title from PDF of title page.<br>Document formatted into pages; contains 117 pages.<br>Thesis (M.S.)--University of South Florida, 2003.<br>Includes bibliographical references.<br>Text (Electronic thesis) in PDF format.<br>ABSTRACT: Bacterial source tracking (BST) methods often involve the use of phenotypic or genotypic fingerprinting techniques to compare indicator bacteria such as Escherichia coli isolated from unknown sources against a library of fingerprints from indicator bacteria found in the feces of various known source animals. The predictive capability of a library is based in part

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Roberto, Alescia. "METAL EFFECTS ON FRESHWATER MICROBIAL COMMUNITY COMPOSITION, STRUCTURE, AND FUNCTION IN AN URBAN STREAM." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543839535987157.

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Paulson, Philip Theodor. "California Livestock Owners: An Assessment of Familiarity with New Antimicrobial Rules and Access to Educational Outreach." DigitalCommons@CalPoly, 2019. https://digitalcommons.calpoly.edu/theses/2012.

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The purpose of this research is to support the California Department of Food & Agriculture (CDFA) with education and outreach about recent changes regarding antimicrobial use in livestock, and to enhance their emergency communications network. This was done by characterizing a population of small-scale livestock owners underserved with regards to educational outreach about animal health issues, such as antimicrobial use rules. The project also seeks to enhance public understanding of the importance of responsible antimicrobial use in animal and human health. To accomplish this, the study used

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Lê, Hung. "Formulation et évaluation de nanovecteurs polymères porteurs d'anticorps pour une délivrance ciblée d'antibiotiques." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR133.

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Le traitement conventionnel par des antibiotiques des infections chroniques devient actuellement difficile en raison du fort développement de la résistance aux antibiotiques. Des études récentes ont montré que la modification du protocole d’administration des antibiotiques par des nanoparticules (nanomédecine) peut améliorer l’efficacité de l’antibiothérapie, réduire l’apparition de résistances aux antibiotiques et augmenter la durée de vie de nouveaux antibiotiques. L’objectif de ce travail a été de concevoir des nanoparticules polymères chargées en antibiotiques et capables de cibler spécifi

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Charretier, Yannick. "Identification, résistance, virulence et typage : une nouvelle application de la spectrométrie de masse pour la microbiologie clinique." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10040.

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La spectrométrie de masse de type MALDI-TOF vient d'être largement adoptée dans les laboratoires de microbiologie clinique, qu'ils soient de ville ou hospitalier. Le MALDI-TOF est maintenant utilisée en routine pour l'identification des micro-organismes. Les micro-organismes sont identifiés en quelques minutes à un coût minime et avec une meilleure précision qu'en utilisant les méthodes conventionnelles. Le MALDI-TOF permet une identification microbienne révolutionnaire mais il ne permet pas aisément la détection de résistances aux antimicrobiens ou de facteurs de virulence. Le travail de thès

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Barbier, Maxime. "Histoire évolutive et propagation de la tuberculose à échelle planétaire : vers une approche intégrée combinant la génomique des populations et le typage multi-locus." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEP051/document.

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D’après un rapport de l’OMS, la tuberculose reste en 2015 l’une des 10 premières causes de décès à l’échelle mondiale. De ce fait, en matière de santé, éradiquer la maladie à l’horizon 2030 est un des objectifs majeurs fixés par les Nations Unies. La bactérie responsable de cette infection, Mycobacterium tuberculosis, est un pathogène obligatoire dont l’origine et l’évolution sont intrinsèquement liées à celles de son hôte principal, Homo sapiens. En effet, les souches actuelles de tuberculose présentent, tout comme l’homme, une forte structure phylogénétique, trace de leur origine géographiqu

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Akhtar, Mastura. "Public health aspects of the house fly, Musca domestica L. (Diptera: muscidae) - Enterococcus spp. association." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/769.

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Pietsch, Franziska. "Evolution of Antibiotic Resistance." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265018.

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The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. A better understanding of the evolution of resistance could help in developing strategies to slow down the spread of antimicrobial drug resistance. In this thesis we investigated the evolution of resistance to two important antibiotics, rifampicin and ciprofloxacin, paying special attention to the resistance patte

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Laxminarayan, Ramanan. "Economics of antibiotic resistance /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7412.

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Börjesson, Stefan. "Antibiotic Resistance in Wastewater : Methicillin-resistant Staphylococcus aureus (MRSA)and antibiotic resistance genes." Doctoral thesis, Linköpings universitet, Medicinsk mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17709.

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A large part of the antibiotics consumed ends up in wastewater, and in the wastewater the antibiotics may exert selective pressure for or maintain resistance among microorganisms. Antibiotic resistant bacteria and genes encoding antibiotic resistance are commonly detected in wastewater, often at higher rates and concentrations compared to surface water. Wastewater can also provide favourable conditions for the growth of a diverse bacterial community, which constitutes a basis for the selection and spread of antibiotic resistance. Therefore, wastewater treatment plants have been suggested to pl

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Kénanian, Gérald. "Staphylococcus aureus se met transitoirement en dormance pour utiliser les acides gras de l'hôte et échapper à une inhibition par un anti-FASII : quel signal active son réveil ?" Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS242.

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Le traitement des infections dues aux bactéries multirésistantes aux antibiotiques est un défi médical majeur du 21ème siècle. Ce défi a incité la recherche de cibles ayant des fonctions essentielles pour le développement de nouveaux antibiotiques. Les enzymes de la voie FASII, responsables de la synthèse des acides gras (AG), sont considérées comme essentielles et de nombreux antibiotiques, appelés anti-FASII, ont été développés pour lutter contre des pathogènes du phylum des Firmicutes. Cependant, notre laboratoire a montré que plusieurs pathogènes contournent l’inhibition des anti-FASII par

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