Academic literature on the topic 'Antibiotics; PBDs'

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Journal articles on the topic "Antibiotics; PBDs"

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Janata, J., Z. Kamenik, R. Gazak, S. Kadlcik, and L. Najmanova. "Biosynthesis and incorporation of an alkylproline-derivative (APD) precursor into complex natural products." Natural Product Reports 35, no. 3 (2018): 257–89. http://dx.doi.org/10.1039/c7np00047b.

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Deng, Zhuo, Jing Wang, Wentao Lyu, et al. "Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds." Journal of Immunology Research 2018 (November 19, 2018): 1–13. http://dx.doi.org/10.1155/2018/5492941.

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Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. Augmenting the synthesis of endogenous host defense peptides (HDPs) has emerged as a promising antibiotic-alternative approach to disease control and prevention. To facilitate the identification of HDP inducers for swine use, we developed a stable luciferase reporter cell line, IPEC-J2/PBD3-luc, through permanent integration of a luciferase reporter gene driven by a 1.1 kb porcine β-defensin 3 (PBD3) gene promoter in porcine IPEC-J2 intestinal epithelial cell
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Li, Wei, Ankush Khullar, ShenChieh Chou, Ashley Sacramo, and Barbara Gerratana. "Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic." Applied and Environmental Microbiology 75, no. 9 (2009): 2869–78. http://dx.doi.org/10.1128/aem.02326-08.

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ABSTRACT Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds with significant antitumor properties. Among the pyrrolo[1,4]benzodiazepines (PBDs) sibiromycin, one of two identified glycosylated PBDs, displays the highest affinity for DNA and the most potent antitumor properties. Despite the promising antitumor properties clinical trials of sibiromycin were precluded by the cardiotoxicity effect in animals attributed to the presence of the C-9 hydroxyl group. As a first step toward the development of sibiromycin analogs,
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Fox, George A., David J. Leasa, William J. Sibbald, and David G. McCormack. "Reproducibility of Protected Brush Catheter Specimen Cultures in Critically Ill Patients with Suspected Nosocomial Pneumonia." Canadian Respiratory Journal 2, no. 3 (1995): 173–78. http://dx.doi.org/10.1155/1995/237924.

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OBJECTIVE: To determine the reproducibility of two protected brush catheter (PBC) specimens obtained during the same bronchoscopy in critically ill patients with suspected ventilator associated pneumonia.DESIGN: Prospective, observational study.SETTING: Two university-affiliated multidisciplinary intensive care un its with a combined total of 50 beds.PATIENTS: A total of 75 (50 male. 25 female) patients with 84 episodes of suspected ventilator associated pneumonia were studied be tween January 1, 1991 and June 30, 1992. Age was 60.7±1.9 (mean ± SEM) years, and mean APACHE II score was 22.4±2.0
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Ye, Mao, Mingming Sun, Jinzhong Wan, et al. "Feasibility of an enhanced washing process to extract PBDEs/heavy metals/antibiotics from antibiotic resistance gene-affected soil with aqueous DNA followed by microbial augmentation." Journal of Soils and Sediments 16, no. 3 (2015): 954–65. http://dx.doi.org/10.1007/s11368-015-1291-3.

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Pierce, Kristina B., Rebecca Barr, Aubrie Hopper, et al. "300. Pediatric Center Evaluation of the BioFire® Blood Culture Identification 2 Panel Versus the Original BioFire®FilmArray® Blood Culture Identification Panel for the Detection of Microorganisms and Resistance Markers in Positive Blood Cultures." Open Forum Infectious Diseases 7, Supplement_1 (2020): S148—S149. http://dx.doi.org/10.1093/ofid/ofaa439.343.

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Abstract Background Studies show a rising annual incidence of severe sepsis, with bloodstream infections continuing to impact children. Rapid identification of causative agents and timely administration of targeted therapy can positively impact patient outcomes and improve antibiotic stewardship. The BioFire® Blood Culture Identification 2 (BCID2) Panel (BioFire Diagnostics, LLC), an updated version of the FDA-cleared BioFire® FilmArray® Blood Culture Identification (BCID) Panel, designed for use on positive blood cultures (PBCs), assesses 43 analytes, including 17 novel analytes (8 bacterial,
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Wang, Jing, Wentao Lyu, Wei Zhang, et al. "Discovery of natural products capable of inducing porcine host defense peptide gene expression using cell-based high throughput screening." Journal of Animal Science and Biotechnology 12, no. 1 (2021). http://dx.doi.org/10.1186/s40104-020-00536-0.

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Abstract Background In-feed antibiotics are being phased out in livestock production worldwide. Alternatives to antibiotics are urgently needed to maintain animal health and production performance. Host defense peptides (HDPs) are known for their broad-spectrum antimicrobial and immunomodulatory capabilities. Enhancing the synthesis of endogenous HDPs represents a promising antibiotic alternative strategy to disease control and prevention. Methods To identify natural products with an ability to stimulate the synthesis of endogenous HDPs, we performed a high-throughput screening of 1261 natural
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Schechter, Marcos C., Mohammed K. Ali, Benjamin B. Risk, et al. "Percutaneous Bone Biopsy for Diabetic Foot Osteomyelitis: A Systematic Review and Meta-Analysis." Open Forum Infectious Diseases 7, no. 10 (2020). http://dx.doi.org/10.1093/ofid/ofaa393.

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Abstract Background Diabetes is the leading cause of lower extremity nontraumatic amputation globally, and diabetic foot osteomyelitis (DFO) is usually the terminal event before limb loss. Although guidelines recommend percutaneous bone biopsy (PBB) for microbiological diagnosis of DFO in several common scenarios, it is unclear how frequently PBBs yield positive cultures and whether they cause harm or improve outcomes. Methods We searched the PubMed, EMBASE, and Cochrane Trials databases for articles in any language published up to December 31, 2019, reporting the frequency of culture-positive
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Laila, Amar, Nicole Topakas, Emily Farr, et al. "Barriers and facilitators of household provision of dairy and plant-based dairy alternatives in families with preschool-age children." Public Health Nutrition, February 19, 2021, 1–13. http://dx.doi.org/10.1017/s136898002100080x.

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Abstract Objective: This study aimed to explore barriers and facilitators of the provision of dairy and plant-based dairy alternatives (PBDA) by parents of preschool-age children, a previously unexplored area of research. Design: Five focus groups of parents were conducted and audio-recorded. Verbatim transcripts were analysed using thematic analysis. Setting: University of Guelph, in Guelph, ON, Canada in 2019. Participants: Thirty-two (n 19 mothers, 13 fathers) parents of preschool-age children. Most (59 %) were university or college educated. Results: Facilitators common to both dairy and P
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Schorn, Michelle A., Peter A. Jordan, Sheila Podell, et al. "Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical Dysideidae Sponges." mBio 10, no. 3 (2019). http://dx.doi.org/10.1128/mbio.00821-19.

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ABSTRACT Marine sponges are recognized as valuable sources of bioactive metabolites and renowned as petri dishes of the sea, providing specialized niches for many symbiotic microorganisms. Sponges of the family Dysideidae are well documented to be chemically talented, often containing high levels of polyhalogenated compounds, terpenoids, peptides, and other classes of bioactive small molecules. This group of tropical sponges hosts a high abundance of an uncultured filamentous cyanobacterium, Hormoscilla spongeliae. Here, we report the comparative genomic analyses of two phylogenetically distin
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Dissertations / Theses on the topic "Antibiotics; PBDs"

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Zioga, Georgia. "Studies on the reaction of pyrrolobenzodiazepines with nucleophiles." Thesis, University of Portsmouth, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298374.

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Book chapters on the topic "Antibiotics; PBDs"

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Thurston, David E. "Advances in the Study of Pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) Antitumour Antibiotics." In Molecular Aspects of Anticancer Drug-DNA Interactions. Macmillan Education UK, 1993. http://dx.doi.org/10.1007/978-1-349-12356-8_3.

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