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Relevant bibliographies by topics / Antibody functional repertoire

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Journal articles

Academic literature on the topic 'Antibody functional repertoire'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "Antibody functional repertoire"

1

Raybould, Matthew I. J., Claire Marks, Aleksandr Kovaltsuk, Alan P. Lewis, Jiye Shi, and Charlotte M. Deane. "Public Baseline and shared response structures support the theory of antibody repertoire functional commonality." PLOS Computational Biology 17, no. 3 (2021): e1008781. http://dx.doi.org/10.1371/journal.pcbi.1008781.

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The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response to immunodominant epitopes. Sequence-based repertoire analysis has so far offered little evidence for this phenomenon. For example, a recent study estimated the number of shared (‘public’) antibody clonotypes in circulating baseline repertoires to be around 0.02% across ten unrelated individuals. However, to engage the same epitope, antibodies only require a similar binding site structure and the pres

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2

Collins, Andrew M., Yan Wang, Krishna M. Roskin, Christopher P. Marquis, and Katherine J. L. Jackson. "The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1676 (2015): 20140236. http://dx.doi.org/10.1098/rstb.2014.0236.

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The human and mouse antibody repertoires are formed by identical processes, but like all small animals, mice only have sufficient lymphocytes to express a small part of the potential antibody repertoire. In this study, we determined how the heavy chain repertoires of two mouse strains are generated. Analysis of IgM- and IgG-associated VDJ rearrangements generated by high-throughput sequencing confirmed the presence of 99 functional immunoglobulin heavy chain variable (IGHV) genes in the C57BL/6 genome, and inferred the presence of 164 IGHV genes in the BALB/c genome. Remarkably, only five IGHV

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3

Robinson, William H. "Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery." Nature Reviews Rheumatology 11, no. 3 (2014): 171–82. http://dx.doi.org/10.1038/nrrheum.2014.220.

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4

Zheng, Tianqing, Jia Xie, Zhuo Yang, et al. "Antibody selection using clonal cocultivation of Escherichia coli and eukaryotic cells in miniecosystems." Proceedings of the National Academy of Sciences 115, no. 27 (2018): E6145—E6151. http://dx.doi.org/10.1073/pnas.1806718115.

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We describe a method for the rapid selection of functional antibodies. The method depends on the cocultivation of Escherichia coli that produce phage with target eukaryotic cells in very small volumes. The antibodies on phage induce selectable phenotypes in the target cells, and the nature of the antibody is determined by gene sequencing of the phage genome. To select functional antibodies from the diverse antibody repertoire, we devised a selection platform that contains millions of picoliter-sized droplet ecosystems. In each miniecosystem, the bacteria produce phage displaying unique members

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5

de Bourcy, Charles F. A., Cesar J. Lopez Angel, Christopher Vollmers, Cornelia L. Dekker, Mark M. Davis, and Stephen R. Quake. "Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging." Proceedings of the National Academy of Sciences 114, no. 5 (2017): 1105–10. http://dx.doi.org/10.1073/pnas.1617959114.

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The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elderly individuals before and after influenza vaccination. We determined that BCR repertoires become increasingly specialized over a span of decades, but less plastic. In 50% of the elderly individuals, a large space in the repertoire was occupied

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6

Schwimmer, Lauren J., Betty Huang, Hoa Giang, et al. "Discovery of diverse and functional antibodies from large human repertoire antibody libraries." Journal of Immunological Methods 391, no. 1-2 (2013): 60–71. http://dx.doi.org/10.1016/j.jim.2013.02.010.

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7

Nobrega, Alberto, Alf Grandien, Matthias Haury, Laura Hecker, Evelyne Malanchère, and Antonio Coutinho. "Functional diversity and clonal frequencies of reactivity in the available antibody repertoire." European Journal of Immunology 28, no. 4 (1998): 1204–15. http://dx.doi.org/10.1002/(sici)1521-4141(199804)28:04<1204::aid-immu1204>3.0.co;2-g.

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8

Kodangattil, Sreekumar, Christine Huard, Cindy Ross, et al. "The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing." mAbs 6, no. 3 (2014): 628–36. http://dx.doi.org/10.4161/mabs.28059.

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9

Maleckar, J. R., and L. A. Sherman. "The composition of the T cell receptor repertoire in nude mice." Journal of Immunology 138, no. 11 (1987): 3873–76. http://dx.doi.org/10.4049/jimmunol.138.11.3873.

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Abstract Previous results from several laboratories have demonstrated the presence of functional T lymphocytes in congenitally athymic (nude) mice. The present study represents an analysis of the T cell receptor repertoire exhibited by such cells. Clones of H-2Kb-specific cytotoxic T lymphocytes (CTL) were generated under primary limiting dilution conditions by using spleen cells from nude mice. These clones were analyzed on a panel of Kb mutant target cells to assess the receptor specificity of each clone. Unlike thymic bearing mice the CTL repertoires of which are exceedingly diverse, it was

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10

Kirchenbaum, Greg A., Giuseppe A. Sautto, Rodrigo B. Abreu, Paul V. Lehmann, and Ted M. Ross. "Assessment of Antibody Functional Affinity using FluoroSpot." Journal of Immunology 204, no. 1_Supplement (2020): 86.11. http://dx.doi.org/10.4049/jimmunol.204.supp.86.11.

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Abstract Studies of B cell immunity often rely upon serologic methodologies that primarily assess antibody specificity. However, functional affinity of the antigen-specific antibody repertoire is a key determinant of protective efficacy. Presently, detailed assessment of single B cell/antibody functional affinity is labor-intensive and low-throughput. Therefore, we sought to evaluate whether B cell FluoroSpot assays would enable distinction between B cells with differential functional affinity since fluorescent intensity is directly proportional to antibody abundance in this assay. To test our

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