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Journal articles on the topic 'Antibody maintenance'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Manz, Rudolf A., Anja E. Hauser, Falk Hiepe, and Andreas Radbruch. "MAINTENANCE OF SERUM ANTIBODY LEVELS." Annual Review of Immunology 23, no. 1 (2005): 367–86. http://dx.doi.org/10.1146/annurev.immunol.23.021704.115723.

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2

Golfier, Camille, and Gilles Salles. "Antibody Therapy Maintenance in Follicular Lymphoma." Hematology/Oncology Clinics of North America 34, no. 4 (2020): 689–99. http://dx.doi.org/10.1016/j.hoc.2020.02.005.

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3

Weinberger, Birgit, Michael Keller, and Beatrix Grubeck-Loebenstein. "Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus." Immunity & Ageing 14, no. 1 (2017): 16. https://doi.org/10.1186/s12979-017-0099-y.

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<strong>Abstract: </strong>Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed controversially. We have demonstrated that recall responses to diphtheria vaccination are frequently insufficient in elderly persons and that antibody concentrations decline substantially within 5 years. In the current study we show that within a cohort of healthy elderly (<i>n</i> = 87; median age 71 years, range 66–92) antibody responses to a booster vaccination

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Inamine, Ayako, Yoshitaka Okamoto, Masashi Arima, and Takeshi Tokuhisa. "The maintenance of the IgE antibody secreting cells." Journal of Japan Society of Immunology & Allergology in Otolaryngology 29, no. 3 (2011): 215–20. http://dx.doi.org/10.5648/jjiao.29.215.

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Cattran, Daniel C., and Michelle A. Hladunewich. "Maintenance Immunosuppression in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis." American Journal of Kidney Diseases 57, no. 6 (2011): 818–21. http://dx.doi.org/10.1053/j.ajkd.2011.03.006.

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Chistyakova, Elena, and Rashida Orlova. "Maintenance therapy with monoclonal antibodies in metastatic HER2-positive breast cancer: A review of studies." Vestnik of Saint Petersburg University. Medicine 18, no. 1 (2023): 63–69. http://dx.doi.org/10.21638/spbu11.2023.105.

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Maintenance therapy is a medical treatment after achieving stabilization, partial or complete response by the first line therapy of a metastatic malignant tumor. The goals of such treatment are to maintain the effect of the first line therapy, to increase progression-free survival, and, in some cases, overall survival. Targeted monoclonal antibody therapy is a maintenance treatment option widely used in clinical practice for metastatic HER2-positive breast cancer, but it remains one of the least studied. This analysis of available world studies was carried out in order to form an idea about th

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Prechl, József. "A generalized quantitative antibody homeostasis model: maintenance of global antibody equilibrium by effector functions." Clinical & Translational Immunology 6, no. 11 (2017): e161. http://dx.doi.org/10.1038/cti.2017.50.

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8

Guillevin, Loïc, and Benjamin Terrier. "Maintenance of Remission in antineutrophil cytoplasm antibody-associated vasculitides." International Journal of Rheumatic Diseases 22 (April 19, 2018): 100–104. http://dx.doi.org/10.1111/1756-185x.13303.

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Kirchner, V. A., T. M. Suszynski, D. M. Radosevich, et al. "Anti-CD25 Antibody (Daclizumab) Maintenance Therapy in Pancreas Transplantation." Transplantation Proceedings 42, no. 6 (2010): 2003–5. http://dx.doi.org/10.1016/j.transproceed.2010.05.083.

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Yen, Cheng-Chieh, Shang-Yi Lin, Szu-Chia Chen, Yi-Wen Chiu, Jer-Ming Chang, and Shang-Jyh Hwang. "COVID-19 Vaccines in Patients with Maintenance Hemodialysis." Journal of Personalized Medicine 11, no. 8 (2021): 789. http://dx.doi.org/10.3390/jpm11080789.

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The COVID-19 pandemic has infected more than 180 million people and caused more than 3.95 million deaths worldwide. In addition to personal hygiene, augmented cleaning, social distancing, and isolation, vaccine development and immunization are essential for this highly contagious disease. Patients with maintenance hemodialysis (MHD) have a greater risk of COVID-19 infection owing to their comorbidities, defective immunity, and repeated crowded in-center dialysis settings. However, many patients hesitate to get vaccinated because of their misunderstandings. The Efficacy of COVID-19 vaccination

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Brand, C. L., P. N. Jorgensen, U. Knigge, et al. "Role of glucagon in maintenance of euglycemia in fed and fasted rats." American Journal of Physiology-Endocrinology and Metabolism 269, no. 3 (1995): E469—E477. http://dx.doi.org/10.1152/ajpendo.1995.269.3.e469.

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The role of glucagon in the regulation of blood glucose in fed and fasted anesthetized rats was studied by injecting intravenously 4 ml/kg of a high-capacity (40 nmol/ml) high-affinity (0.6 x 10(11) mol/l) monoclonal glucagon antibody. Blood glucose was lowered by the antibody by 2 mmol/l in fed rats but remained unchanged in 10- and 48-h-fasted rats. Antibody injection significantly reduced plasma insulin in both fed and 10-h-fasted rats. In 10-h-fasted rats, propranolol injection decreased blood glucose by 0.6 mmol/l, and combined with antibody administration, a decrease by 1.1 mmol/l was ob

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Steinhart, Hillary. "Maintenance Therapy in Crohn's Disease." Canadian Journal of Gastroenterology 14, suppl c (2000): 23C—28C. http://dx.doi.org/10.1155/2000/480782.

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Symptoms of active Crohn’s disease may respond to one or more of a number of classes of drug therapies. These include systemic glucocorticoids, budesonide, sulphasalazine, mesalazine (5-aminosalicylates), immunosuppressive agents and antibiotics. More recently, a chimeric mouse-human antibody to tumour necrosis factor (infliximab) has been shown to induce clinical remission and endoscopic improvement in patients with moderately active Crohn’s disease refractory to other therapies. Despite this wide range of existing therapies and the potential of emerging biological therapies, recurrent Crohn’

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13

Attias, Philippe, Hamza Sakhi, Philippe Rieu, et al. "Antibody response to the BNT162b2 vaccine in maintenance hemodialysis patients." Kidney International 99, no. 6 (2021): 1490–92. http://dx.doi.org/10.1016/j.kint.2021.04.009.

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14

Simonovic, Mladen, Svetlana Zlatanovic-Milosevic, Miroslav Vrvic, and Branislav Simonovic. "Recombinant expression of monovalent and bivalent anti-TNT-antibodies: Evaluation of different expression systems." Journal of the Serbian Chemical Society 73, no. 2 (2008): 139–45. http://dx.doi.org/10.2298/jsc0802139s.

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Monoclonal 11B3 anti-TNT (trinitrotoluene) antibody was expressed as a monovalent and bivalent form using different prokaryotic and eukaryotic expression systems. Recombinant expression in Escherichia coli, mammalian cells and the methylotrophic yeast Pichia pastoris was performed to obtain disulfide-linked and glycosylated antibody forms. The generation of antibody and subsequent evaluation of the expression rates were performed using intracellular, excretory and periplasmatic expression techniques. All methods involved striving for native expressed antibody with maintenance of its functional

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15

Ikeda, Yuki, Kenichi Fukunari, Saori Uchiumi, et al. "A case of anti-neutrophil cytoplasmic antibody-associated vasculitis with anti-glomerular basement membrane antibodies that was successfully treated with mizoribine as a safe and effective remission maintenance therapy with prednisolone and plasma exchange." CEN Case Reports 9, no. 1 (2019): 42–47. http://dx.doi.org/10.1007/s13730-019-00423-2.

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Abstract We herein report the case of myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with anti-glomerular basement membrane (anti-GBM) antibody positivity that successfully treated with mizoribine (MZR) as an immunosuppressive drug for remission maintenance therapy after the initiation of dialysis in addition to plasma exchange (PE) and glucocorticoid treatment to control the disease condition. A 79-year-old woman developed serious renal dysfunction and pulmonary alveolar hemorrhaging due to MPO–ANCA and anti-GBM antibody double-positive vasculitis. She

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16

Espinoza, LR. "Antiphospholipid Antibody Syndrome: Treatment." Lupus 5, no. 5 (1996): 456–57. http://dx.doi.org/10.1177/096120339600500525.

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Of the many clinical manifestations seen in the antiphospholipid antibody syndrome (APAS), two deserve major therapeutic consideration: recurrent fetal loss and vascular thromboses. Treatment of these two major complications remain empirical, although recent studies appear to indicate the beneficial use of multiple therapeutic options including low dose aspirin, alone or in combination with a moderate amount of prednisone, heparin and intravenous gammaglobulin for the prevention of fetal loss, and longterm anticoagulation with maintenance of an international normalized ratio (INR) of 3 to 4 as

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Adedokun, Omoniyi J., George R. Gunn, Jocelyn H. Leu, et al. "Immunogenicity of Golimumab and its Clinical Relevance in Patients With Ulcerative Colitis." Inflammatory Bowel Diseases 25, no. 9 (2019): 1532–40. http://dx.doi.org/10.1093/ibd/izz003.

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Abstract Background Antidrug antibody (ADA) detection with standard bridging enzyme immunoassays (EIA) can yield false-negative results or underestimate titers through drug interference. A more sensitive assay was needed to determine clinical impact of antigolimumab antibodies. Methods A high-sensitivity, drug-tolerant EIA (DT-EIA) was developed and cross-validated against the original EIA, and samples from induction/maintenance studies in golimumab-treated patients with ulcerative colitis were analyzed for ADAs using both methods. Immunogenicity results were compared, and pharmacokinetic, eff

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Donaldson, Stephen L., Marie H. Kosco, Andras K. Szakal, and John G. Tew. "Localization of Antibody-Forming Cells in Draining Lymphoid Organs During Long-Term Maintenance of the Antibody Response." Journal of Leukocyte Biology 40, no. 2 (1986): 147–57. http://dx.doi.org/10.1002/jlb.40.2.147.

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19

Langley, William A., Scott N. Mueller, and Rafi Ahmed. "Memory B cells are required to maintain long-lived plasma cells in mice following viral infections (132.16)." Journal of Immunology 182, no. 1_Supplement (2009): 132.16. http://dx.doi.org/10.4049/jimmunol.182.supp.132.16.

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Abstract Antibody responses have been found to last for life following lymphocytic choriomeningitis virus (LCMV) infection in mice and have been estimated to have a half-life of up to 200 years for some pathogens in humans. These antibodies are produced by long-lived plasma cells which have been shown to have a half-life of at least 138 days in mice. However, the role of memory B cells in the maintenance of plasma cell numbers remains unclear. We have been attempting to define this role by infecting hCD20 transgenic mice with viral pathogens, treating them with rituximab (an anti-CD20 antibody

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Rhee, Eugene P., Karen A. Laliberte, and John L. Niles. "Rituximab as Maintenance Therapy for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis." Clinical Journal of the American Society of Nephrology 5, no. 8 (2010): 1394–400. http://dx.doi.org/10.2215/cjn.08821209.

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21

Smith, Rona M., Rachel B. Jones, Mary-Jane Guerry, et al. "Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis." Arthritis & Rheumatism 64, no. 11 (2012): 3760–69. http://dx.doi.org/10.1002/art.34583.

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22

Hoffman, Gary S., John H. Stone, and Carol Langford. "Implications of antineutrophil cytoplasmic antibody status when switching to maintenance therapy." Arthritis & Rheumatism 53, no. 1 (2005): 1–2. http://dx.doi.org/10.1002/art.20921.

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23

Chauvin, Camille, Sruthi Vijaya Retnakumar, and Jagadeesh Bayry. "Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines." Cell Reports Medicine 4, no. 7 (2023): 101117. http://dx.doi.org/10.1016/j.xcrm.2023.101117.

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24

Cheng, Chung-Yi, Te-Chao Fang, Hung-Wei Liao, et al. "The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection." Vaccines 10, no. 2 (2022): 338. http://dx.doi.org/10.3390/vaccines10020338.

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Background: Chronic kidney disease (CKD) patients tend to have a reduced immune response to infection and vaccination. The efficacy of current available COVID-19 vaccines in CKD patients has not been widely evaluated. Methods: In the present study, three hundred and eight chronic dialysis patients received ChAdOx1 nCoV-19 (Oxford-AstraZeneca, AZ). Blood tests using an antibody against the receptor-binding domain (RBD) of the S1 subunit of the SARS-CoV-2 spike protein had performed at four designed time points before and after the first and second vaccine. Results: The mean age of patients was

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Hirai, Fumihito, Teruyuki Takeda, Yasumichi Takada, et al. "Efficacy of enteral nutrition in patients with Crohn’s disease on maintenance anti-TNF-alpha antibody therapy: a meta-analysis." Journal of Gastroenterology 55, no. 2 (2019): 133–41. http://dx.doi.org/10.1007/s00535-019-01634-1.

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Abstract Enteral nutrition (EN) is effective in Crohn’s disease (CD) patients and has been shown to have an inhibitory effect on loss of response to anti-tumor necrosis factor (TNF)-alpha antibody therapy; however, the current level of evidence is not sufficient. The objective of this meta-analysis was to determine whether EN in combination anti-TNF-alpha antibody therapy is useful in maintaining remission. PubMed was used to identify all relevant studies. A total of nine articles were identified including one randomized control trial, two prospective cohort studies, and six retrospective coho

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Awad, Neveen, Shahd Hafiz, Abdurahman Albeity, and Hani Almoallim. "A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis." Case Reports in Rheumatology 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/7275860.

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Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is a multisystem autoimmune disease affecting mainly microscopic blood vessels due to circulating autoantibodies against neutrophil cytoplasmic antigens. We report a case of a 57-year-old female patient presenting with hemoptysis, sinusitis, and conjunctivitis. Based on lung biopsy, the diagnosis of antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) was established. She was put on rituximab as induction and maintenance therapy. She responded initially to rituximab as induction therapy but failed to r

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Hikida, Masaki, Stefano Casola, Noriko Takahashi та ін. "PLC-γ2 is essential for formation and maintenance of memory B cells". Journal of Experimental Medicine 206, № 3 (2009): 681–89. http://dx.doi.org/10.1084/jem.20082100.

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Resting antigen-experienced memory B cells are thought to be responsible for the more rapid and robust antibody responses after antigen reencounter, which are the hallmark of memory humoral responses. The molecular basis for the development and survival of memory B cells remains largely unknown. We report that phospholipase C (PLC) γ2 is required for efficient formation of germinal center (GC) and memory B cells. Moreover, memory B cell homeostasis is severely hampered by inducible loss of PLC-γ2. Accordingly, mice with a conditional deletion of PLC-γ2 in post-GC B cells had an almost complete

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Zhuang, Yan, James E. Futse, Wendy C. Brown, Kelly A. Brayton, and Guy H. Palmer. "Maintenance of Antibody to Pathogen Epitopes Generated by Segmental Gene Conversion Is Highly Dynamic during Long-Term Persistent Infection." Infection and Immunity 75, no. 11 (2007): 5185–90. http://dx.doi.org/10.1128/iai.00913-07.

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ABSTRACT Multiple bacterial and protozoal pathogens utilize gene conversion to generate rapid intrahost antigenic variation. Both large- and small-genome pathogens expand the size of the variant pool via a combinatorial process in which oligonucleotide segments from distinct donor loci are recombined in various combinations into expression sites. Although the potential combinatorial diversity generated by this segmental gene conversion mechanism is quite large, the functional variant pool depends on whether immune responses against the recombined segments are generated and maintained, regardle

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Genova, Gianfranco Di, Joanna Roddick, Feargal McNicholl, and Freda K. Stevenson. "Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific." Blood 107, no. 7 (2006): 2806–13. http://dx.doi.org/10.1182/blood-2005-08-3255.

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AbstractHuman subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To probe the dynamics of the Thmem-cell response to antigenic challenge, we investigated subjects following a booster injection with tetanus toxoid (TT). Expansion of TT-specific Thmem cells and cytokine production showed complex kinetics. Strikingly, parallel expansion and cytok

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Khatami, A., A. Peters, H. Robinson, et al. "Maintenance of Immune Response throughout Childhood following Serogroup C Meningococcal Conjugate Vaccination in Early Childhood." Clinical and Vaccine Immunology 18, no. 12 (2011): 2038–42. http://dx.doi.org/10.1128/cvi.05354-11.

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ABSTRACTThe objectives of this study were to evaluate the kinetics of antibody decline through childhood in a longitudinal study of a single cohort following serogroup C meningococcal (MenC) vaccine immunization in early childhood and to calculate the proportion of 11 to 13 year olds with protective levels of bactericidal antibody 10 years after immunization. United Kingdom children aged 11 to 13 years in 2010 who had previously taken part in a longitudinal study at the Oxford Vaccine Group had blood samples drawn between 2001 and 2010. Sera from each time point were analyzed for the MenC seru

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Ueki, Satoshi, Tetsuhisa Hatase, Megumi Kiyokawa, et al. "Visual outcome of aquaporin-4 antibody-positive optic neuritis with maintenance therapy." Japanese Journal of Ophthalmology 65, no. 5 (2021): 699–703. http://dx.doi.org/10.1007/s10384-021-00858-0.

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Birdwell, Kelly A., Mine R. Ikizler, Li Wang, et al. "Seasonal Maintenance of Influenza Vaccine-Induced Antibody Response in Kidney Transplant Recipients." American Journal of Nephrology 36, no. 3 (2012): 201–7. http://dx.doi.org/10.1159/000341653.

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Rodionov, V. I., F. K. Gyoeva, E. Tanaka, A. D. Bershadsky, J. M. Vasiliev, and V. I. Gelfand. "Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain." Journal of Cell Biology 123, no. 6 (1993): 1811–20. http://dx.doi.org/10.1083/jcb.123.6.1811.

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One of the major functions of cytoplasmic microtubules is their involvement in maintenance of asymmetric cell shape. Microtubules were considered to perform this function working as rigid structural elements. At the same time, microtubules play a critical role in intracellular organelle transport, and this fact raises the possibility that the involvement of microtubules in maintenance of cell shape may be mediated by directed transport of certain cellular components to a limited area of the cell surface (e.g., to the leading edge) rather than by their functioning as a mechanical support. To te

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KAMPA, Katia Cristina, Marcela Rocha LOURES, Cláudia Alexandra Pontes IVANTES, Ricardo Rasmussen PETTERLE, and Maria Lúcia Alves PEDROSO. "THE EVALUATION OF INFLIXIMAB TROUGH LEVEL FAVORS MAINTENANCE THERAPY OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE." Arquivos de Gastroenterologia 60, no. 1 (2023): 48–56. http://dx.doi.org/10.1590/s0004-2803.202301000-07.

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ABSTRACT Background: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic diseases that result from the deregulation of the mucosal immune system of the gastrointestinal tract. The use of biological therapies, including infliximab (IFX), is one of the strategies to treat both CD and UC. The IFX treatment is monitored by complementary tests, namely: fecal calprotectin (FC); C-reactive protein (CRP); and endoscopic and cross-sectional imaging. Besides, serum IFX evaluation and antibody detection are also used. Objective: To evaluate trough levels (TL) and antibodies in a population with

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Shashar, Moshe, Naomi Nacasch, Ayelet Grupper, et al. "Humoral Response to Pfizer BNT162b2 Vaccine Booster in Maintenance Hemodialysis Patients." American Journal of Nephrology 53, no. 2-3 (2022): 207–14. http://dx.doi.org/10.1159/000521676.

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<b><i>Introduction:</i></b> Coronavirus disease is associated with increased morbidity and mortality in maintenance hemodialysis (MHD) patients. Recent breakthrough infection in vaccinated people has led some authorities to recommend a booster dose for patients fully vaccinated 5–8 months ago. We aimed to assess the humoral response of MHD patients following a booster dose with the BNT162b2 vaccine. <b><i>Methods:</i></b> The study included 102 MHD patients vaccinated with 2 doses of the BNT162b2 (Pfizer-BioNTech) vaccine. A third dose (booster)

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Kima, Peter E., Stephanie L. Constant, Lynn Hannum, et al. "Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis." Journal of Experimental Medicine 191, no. 6 (2000): 1063–68. http://dx.doi.org/10.1084/jem.191.6.1063.

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We show here that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. In these studies, we used mice genetically altered to contain no circulating antibody, with and without functional B cells. This experimental design allowed us to rule out a critical role for B cell antigen presentation in Leishmania pathogenesis. In addition, we show that mice lacking the common γ chain of Fc receptors (FcγRI, FcεRI, and FcγRIII) are similarly refractory to infection with these par

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Carson, Luke Nessan, Ashish Pradhan, and Deepak Subramanian. "Omalizumab-associated eosinophilic granulomatosis with polyangiitis: cause or coincidence?" BMJ Case Reports 14, no. 7 (2021): e240078. http://dx.doi.org/10.1136/bcr-2020-240078.

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Omalizumab is an anti-IgE monoclonal antibody used in severe allergic asthma. Herein, we describe a case of eosinophilic granulomatosis with polyangiitis, which manifested 3 months after initiation of omalizumab therapy, while maintenance corticosteroid therapy dose was unchanged.

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Biedunkiewicz, Bogdan, Leszek Tylicki, Waldemar Ślizień, et al. "Waning Humoral Response after COVID-19 mRNA Vaccination in Maintenance Dialysis Patients and Recovery after a Complementary Third Dose." Vaccines 10, no. 3 (2022): 433. http://dx.doi.org/10.3390/vaccines10030433.

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The aim of this study was to analyze the waning of anti-spike (S) antibodies after mRNA vaccination against COVID-19 in maintenance dialysis patients, and to assess the safety and effectiveness of the complementary third dose. This was a prospective, longitudinal study in which we analyzed the kinetics of antibodies up to six months after a two-dose vaccination (first protocol) in infection-naïve dialysis patients (IN-Ds), previously infected dialysis patients (PI-Ds) and subjects without chronic kidney disease (the controls), as well as their humoral response to the third dose of the same mRN

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Brook, Daniel L., Christine Schalkoff, Hannah M. Piscalko, et al. "914. The Relationship Between Buprenorphine Maintenance Therapy and Hepatitis C Virus Infection, Testing, and Treatment in Southern Appalachian Ohio." Open Forum Infectious Diseases 8, Supplement_1 (2021): S548—S549. http://dx.doi.org/10.1093/ofid/ofab466.1109.

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Abstract Background The hepatitis C virus (HCV) epidemic in the United States is primarily among young people who use drugs (PWUD), especially in rural and Appalachian regions. Buprenorphine maintenance therapy (BMT) may indirectly prevent HCV infection by reducing injection drug use. We aim to assess the relationship between BMT and HCV infection, testing, and treatment among rural PWUD. Methods We conducted a cross-sectional respondent driven sampling survey of 243 PWUD adults in southern Appalachian Ohio from May to November 2019. Participants completed audio computer-assisted self-intervie

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Wineman, JP, S. Nishikawa, and CE Muller-Sieburg. "Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effect of stromal cells and c-kit." Blood 81, no. 2 (1993): 365–72. http://dx.doi.org/10.1182/blood.v81.2.365.365.

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Abstract We show here that mouse pluripotent hematopoietic stem cells can be maintained in vitro on stroma for at least 3 weeks at levels close to those found in bone marrow. The extent of stem cell maintenance is affected by the nature of the stromal cells. The stromal cell line S17 supported stem cells significantly better than heterogeneous, primary stromal layers or the stromal cell line Strofl-1. Stem cells cultured on S17 repopulated all hematopoietic lineages in marrow-ablated hosts for at least 10 months, indicating that this culture system maintained primitive stem cells with extensiv

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Wineman, JP, S. Nishikawa, and CE Muller-Sieburg. "Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effect of stromal cells and c-kit." Blood 81, no. 2 (1993): 365–72. http://dx.doi.org/10.1182/blood.v81.2.365.bloodjournal812365.

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We show here that mouse pluripotent hematopoietic stem cells can be maintained in vitro on stroma for at least 3 weeks at levels close to those found in bone marrow. The extent of stem cell maintenance is affected by the nature of the stromal cells. The stromal cell line S17 supported stem cells significantly better than heterogeneous, primary stromal layers or the stromal cell line Strofl-1. Stem cells cultured on S17 repopulated all hematopoietic lineages in marrow-ablated hosts for at least 10 months, indicating that this culture system maintained primitive stem cells with extensive prolife

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Panneton, Vincent, Sahar Bagherzadeh Yazdchi, Mariko Witalis, Jinsam Chang, and Woong-Kyung Suh. "ICOS-mediated phosphoinositide 3-kinase signaling controls induction and maintenance of collagen-induced arthritis." Journal of Immunology 200, no. 1_Supplement (2018): 163.28. http://dx.doi.org/10.4049/jimmunol.200.supp.163.28.

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Abstract The inducible T-cell costimulator (ICOS) is a key costimulatory receptor facilitating differentiation and function of follicular helper T cells and inflammatory T cells. Rheumatoid arthritis patients were shown to have elevated levels of ICOS+ T cells in the synovial fluid suggesting a potential role of ICOS-mediated T cell costimulation in autoimmune joint inflammation. In this study, using ICOS knockout and knockin mouse models, we found that ICOS-mediated phosphoinositide 3-kinase (PI3K) signaling is required for the induction and maintenance of collagen-induced arthritis (CIA), a

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Nosadini, Margherita, Terrence Thomas, Michael Eyre, et al. "International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis." Neurology - Neuroimmunology Neuroinflammation 8, no. 5 (2021): e1052. http://dx.doi.org/10.1212/nxi.0000000000001052.

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ObjectiveTo create an international consensus treatment recommendation for pediatric NMDA receptor antibody encephalitis (NMDARE).MethodsAfter selection of a panel of 27 experts with representation from all continents, a 2-step Delphi method was adopted to develop consensus on relevant treatment regimens and statements, along with key definitions in pediatric NMDARE (disease severity, failure to improve, and relapse). Finally, an online face-to-face meeting was held to reach consensus (defined as ≥75% agreement).ResultsCorticosteroids are recommended in all children with NMDARE (pulsed IV pref

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Ramanathan, Sudarshini, Shekeeb Mohammad, Esther Tantsis, et al. "Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 2 (2017): 127–37. http://dx.doi.org/10.1136/jnnp-2017-316880.

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ObjectiveWe characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.MethodsWe evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.ResultsThe most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurr

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Chodisetti, Sathi Babu, Adam Fike, Kristen Bricker, Phillip P. Domeier, Nicholas M. Choi, and Ziaur Rahman. "B cell-intrinsic STAT3 regulates the germinal center dark zone." Journal of Immunology 204, no. 1_Supplement (2020): 151.20. http://dx.doi.org/10.4049/jimmunol.204.supp.151.20.

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Abstract Germinal centers (GCs) are sites for antibody diversification, somatic hypermutation (SHM) and antigen specific B cell selection. GCs are anatomically divided into two distinct areas known as dark zone (DZ) and light zone (LZ) where SHM and clonal selection occurs, respectively. Although previous studies have suggested a B cell-intrinsic role of STAT3 in GC maintenance and antibody responses, how STAT3 signaling in B cells may maintain GCs for B cell selection is not clear. Using immunization and infection models, we show that STAT3 in B cells regulates the GC DZ, resulting in decreas

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Walker, Adam G., Scott Sibbel, Curtis Wade, et al. "SARS-CoV-2 Antibody Seroprevalence Among Maintenance Dialysis Patients in the United States." Kidney Medicine 3, no. 2 (2021): 216–22. http://dx.doi.org/10.1016/j.xkme.2021.01.002.

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Kreimer, Susan. "Maintenance Intravenous Immunoglobulin Prevents Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease." Neurology Today 22, no. 10 (2022): 1,29–30. http://dx.doi.org/10.1097/01.nt.0000833124.73576.b5.

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Chaimowitz, Natalia S., Rebecca K. Martin, Joanna Cichy, et al. "A Disintegrin and Metalloproteinase 10 Regulates Antibody Production and Maintenance of Lymphoid Architecture." Journal of Immunology 187, no. 10 (2011): 5114–22. http://dx.doi.org/10.4049/jimmunol.1102172.

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Vandelli, Lorenza, Giuseppe Medici, Anna Maria Savazzi, et al. "Behavior of Antibody Profile against Hepatitis C Virus in Patients on Maintenance Hemodialysis." Nephron 61, no. 3 (1992): 260–62. http://dx.doi.org/10.1159/000186898.

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Golden, David B. K., Ira D. Lawrence, Robert H. Hamilton, Anne Kagey-Sobotka, Martin D. Valentine, and Lawrence M. Lichtenstein. "Clinical correlation of the venom-specific IgG antibody level during maintenance venom immunotherapy." Journal of Allergy and Clinical Immunology 90, no. 3 (1992): 386–93. http://dx.doi.org/10.1016/s0091-6749(05)80019-3.

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