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Dissertations / Theses on the topic 'Anticancer agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Hudnott, Anna Ruth. "Bioreductive anticancer agents." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302640.

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2

Pettersson, Hanna Ilse. "Quinolinequinones as anticancer agents." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249038.

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3

Fryatt, Tara. "Quinolinequinones as bioreductive anticancer agents." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302535.

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4

McKeown, Paul. "Synthesis of novel anticancer agents." Thesis, University of Glasgow, 1996. http://theses.gla.ac.uk/7016/.

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5

Magri, Neal Francis. "Modified taxols as anticancer agents." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/53892.

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Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, succinyl, trichloroethyloxycarbonyl or carbonate linked dibenzylidene protected glucosyl groups. The C-7 position was selectively epimerized under free radical conditions and a 2'-epiacetyltaxol was produced via base catalysed epimerization. The C-2' amide became nucleophilic in the presence of base an

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6

Vervoort, Hélène C. "Novel anticancer agents from Ascidiacea /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p3035904.

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7

Kuder, Craig Heath. "Schweinfurthins as novel anticancer agents." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/840.

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Several members of the schweinfurthin family are potent and selective inhibitors of cancer cell growth in the NCI 60-cell cancer screen. The schweinfurthins display unique activity in this screen which suggests that these compounds have a previously unexploited target. This activity encourages development of the schweinfurthins as anti-cancer agents; however, the scarcity of the natural products has hindered biological evaluation. For this reason, a program was initiated to synthesize the natural products and analogues thereof. These efforts have made 5 natural product schweinfurthins and over

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8

Pan, Ende. "Searching for Anticancer Agents and Antimalarial Agents from Madagascar." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77260.

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In our continuing search for biologically active natural products from Madagascar as part of an International Cooperative Biodiversity Group (ICBG) program, a total of four antiproliferative extracts were studied, leading to the isolation of twelve novel compounds with antiproliferative activity against the A2780 human ovarian cancer line, and one extract with antimalarial activities was studied, which led to the isolation of five new natural products with antimalarial activities against the Dd2 and HB3 malarial parasites. The plants and their metabolites are discussed in the following order:

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9

Gandin, Valentina. "Metal complexes as potential anticancer agents." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426115.

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Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is regarded as one of the most effective drugs, even if severe toxicities and drug resistance phenomena limit its clinical use. Therefore, in recent years there has been a rapid expansion in research and development of novel metal-based anticancer drugs to improve clinical effectiveness, to reduce general toxicity and to broaden the spectrum of activity. The variety of metal ion functions in biology has stimulated the development of new metallodrugs other than Pt drugs with the aim to obtain compounds acti

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10

Mjos, Katja Dralle. "Coordination chemistry of antimicrobial and anticancer agents." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54682.

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The World Health Organization has named the resistance of microbes to known antimicrobial drugs as an increasingly serious threat to global public health. Isolates of the ESKAPE pathogens (E. faecium, S. aureus, K. pneumonia, A. baumanii, P. aeruginosa, and Enterobacter species) are responsible for many nosocomial infections each year that require complicated, and therefore expensive, medical treatment, often leading to death in immune-compromised patients. Over the past 50 years, (fluoro-)quinolone antimicrobial agents have been widely used in the clinic as broad-spectrum antibiotics, but lat

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11

Coldman, Andrew James. "The development of resistance to anticancer agents." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26975.

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The mechanism of resistance of tumor cells to chemotherapeutic agents is explored using probabilistic methods where it is assumed that resistant cells arise spontaneously with a defined frequency. The resistance process is embedded in a discrete time Markov branching process which models the growth of the tumor and contains three seperate cell types: stem, transitional and end cells. Using the asymptotic properties of such models it is shown that the proportion of each type of cell converge to constants almost surely. It is shown that the parameters relating to stem cell behaviour determine th

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12

Zhang, Huizhen. "Liposome drug delivery systems for anticancer agents." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/711.

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Development of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl chains in the phospholipids, small phospholipid headgroup size, the presence of cholesterol, and the presence of PEG-lipid were demonstrated as critical parameters to stabilize the liposome membrane. A liposome formulation of the peptide comprising POPE/POPC/cholesterol/C16 mPEG 2000 ceramide (20.8:31.2:40:8

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13

Nduka, Jane. "New anticancer agents from Chinese medicinal herbs." Thesis, University of Manchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680639.

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14

Whibley, Catherine Evelyn. "South African marine compounds as anticancer agents." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/8393.

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Includes bibliographical references (leaves 149-163).<br>Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the establishment of a screening assay using an oesophageal cancer cell line as a model. It was our hope that this screen would allow us to identify compounds which have activity against oesophageal cancer, that could be used as lead agents for f

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15

Zhang, Weihe. "Design and Synthesis of Potential Anticancer Agents." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288896777.

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16

Adams, Nyssa R. "Protein targets of two novel anticancer agents." Ohio University Honors Tutorial College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1311102442.

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17

Laha, Rumita. "Novel Isosteviol Derivatives as Potential Anticancer Agents." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396.

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18

METALLI, DAVID. "Development of Cdc25Mn derivatives as anticancer agents." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7476.

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Le proteine Ras sono proteine G monomeriche, a basso peso molecolare e dotate di una bassa attività GTPasica intrinseca che svolgono un ruolo chiave nelle vie di trasduzione del segnale coinvolte in processi di crescita e differenziamento cellulare. Ras può funzionare come un vero e proprio interruttore molecolare, trovandosi alternativamente in due stati: uno attivo (legato a GTP) ed uno inattivo (legato a GDP). I passaggi dallo stato attivo a quello inattivo e viceversa possono avvenire spontaneamente, ma la velocità delle due reazioni in questo caso sarebbe molto bassa. Per questo motivo l’

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19

Farley, Sarah J. "Platinum complexes as potential photochemotherapeutic agents." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3769.

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A major challenge of platinum anticancer therapy lies in overcoming the severe side-effects associated with treatment. Photoactivatable PtIV azido complexes, which are stable in the dark and reduced to cytotoxic PtII species upon irradiation, have recently emerged as a potential site-specific treatment. This thesis is concerned with the investigation of PtII and PtIV azido complexes as potential cytotoxic and photochemotherapeutic agents. PtII azido complexes such as [Pt(en)(N3)2] were shown to bind to both 5'-guanosine monophosphate (5'-GMP) and glutathione, at a much reduced rate compared wi

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20

Stewart, Lesley Ann. "Synthesis of heterocyclic compounds as potential anticancer agents." Thesis, University of Glasgow, 1996. http://theses.gla.ac.uk/4936/.

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21

Broggini, Massimo. "Molecular determinants of cellular response to anticancer agents." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288829.

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22

Noffke, Anna Louise. "Arene ruthenium(II) thiosemicarbazone complexes as anticancer agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/66956/.

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This thesis presents the synthesis and characterisation of thiosemicarbazones (TSCs) and their arene ruthenium complexes for the use as anticancer agents. Based on substituted benzaldehyde derivatives, 12 different TSCs were used as N,S-chelating ligands in 24 different ruthenium half-sandwich complexes. The variations in their general structure [(p-cymene)Ru(RTSC)Z]+[A] include the use of both chloride and iodide as monodentate Z ligand. Iodine substituents in the TSC (R = I) were used to introduce a possible tracer moiety. Structure and reactivity elucidations by NMR, ESI-MS and X-ray absorp

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23

Loruthai, Orathai. "Injectable nanoemulsions for the delivery of anticancer agents." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/injectable-nanoemulsions-for-the-delivery-of-anticancer-agents(75802b83-30a0-4e11-aa4a-1a173ceb12aa).html.

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Oil-in-water nanoemulsions (NE), comprising of an oil dispersed in a water and stabilised by a surfactant, have been increasingly explored as vehicles for the delivery of poorlywater soluble drugs. This interest stems from the ability of NE to increase the apparent aqueous solubility of such drugs. The aims of the current study were several fold and included the determination of the molecular architecture and physico-chemical properties of NE to determine their suitability as vehicles for the parenteral delivery of the hydrophobic drugs, testosterone propionate (TP), curcumin (CUR) and docetax

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24

Chardon, Edith. "N-Heterocyclic carbene complexes : toward innovative anticancer agents." Strasbourg, 2011. http://www.theses.fr/2011STRA6265.

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Parmi les agents thérapeutiques utilisés en chimiothérapie, la molécule la plus connue et utilisée dans le monde est le cisplatine ou cis-diamminedichloroplatinum(II) démontrant le potentiel des métaux en chimie médicinale. Malheureusement, le cisplatine engendre de nombreux effets secondaires importants et une résistance cellulaire. Dans la quête de nouveaux agents anticancéreux, les complexes de carbènes N-hétérocycliques (NHC) de métaux de transition constituent des candidats prometteurs. C’est dans ce contexte que s’est inscrit l’objet du projet de thèse qui a consisté en la synthèse et l’

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25

Lim, Zhi Jun. "Ruthenium arene complexes as anticancer agents: an XAS study." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10398.

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Two Ru(III) complexes that have already entered clinical trials, [ImH]trans-[RuCl4(dmso)(Im)] (NAMI-A, Im = imidazole) and [InH]trans-[RuCl4(Ind)2] (KP1019, Ind = indazole), are potential alternatives to Pt chemotherapeutic drugs since they are effective against cancers untreatable by cisplatin. These compounds have been proposed to operate by an “activation by reduction” process, with a reduction of Ru(III) to the more active Ru(II) species in vivo, which has thus generated an interest towards organometallic Ru(II) arene complexes. The leading complexes of this field would be the RAPTA-C pi

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26

Gallego, Palacios Ana 1987. "Corylus avellana: a new biotechnological source of anticancer agents." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/290989.

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The difficulty of increasing taxane production and reducing its costs has prompted a search for new biotechnological sources. The unexpected discovery of taxanes in Corylus avellana has generated considerable interest in studying this plant and its derived cell cultures. We therefore focused this work on the study of cell suspension cultures of C. avellana as a new biotechnological approach to the production of taxol and related taxanes. With this goal, we optimized a scale-up process, the type of elicitor and moment of elicitation, cell culture growth, and an analytical technique to detect th

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27

Tsoukala, Georgia. "Design and Synthesis of Glycosides as Potential Anticancer Agents." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509312.

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28

Haque, Mohammad Rashedul. "Novel STAT3 small-molecule inhibitors as potential anticancer agents." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535504.

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29

Pourgholami, M. H. "Pharmacological studies with potential anticancer agents related to aminoglutethimide." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377873.

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30

Hsu, Wen-Chuan. "The synthesis and investigation of novel bioreductive anticancer agents." Thesis, Cardiff University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344012.

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31

Pearson, Vikki Clark. "The synthesis and biological evaluation of novel anticancer agents." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252471.

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32

Montgomery, Gerard John. "Synthesis and biological evaluation of tyrphostins as anticancer agents." Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294172.

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33

Ganeshapillai, Dharshini. "The synthesis of novel anticancer agents with therapeutic potential." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760760.

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34

Bertrand, Benoit. "Gold-based complexes : synthesis and evaluation as anticancer agents." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS013.

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Depuis sa mise sur le marché à la fin des années 70, le Cisplatin est devenu l’un des pricipaux agents de chimiothérapie anticancéreuse. Actuellement, les composés à base de platine sont présents dans la majorité des coktails de chimiothérapie. Cependant, malgré leur succès clinique, ces composés présentent de nombreux inconvenients comme par exemple de nombreux et graves effets secondaires. Une des stratégies envisagées pour parer à ces défauts a été de remplacer le platine par d’autres métaux de transition. Parmi les différents métaux possibles, l’or est apparu comme particulièrement promett

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35

Shah, Aashay Kirit. "Development of novel anticancer agents based on natural products." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5993.

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My thesis includes the development of two novel anticancer agents based on natural products; OSW-1 analog (ZJ-201) and truncated Superstolide A analog (ZJ-102). OSW-1 is isolated from the bulbs of Ornithogalum saundersiae. It exhibits an extremely potent anticancer activity against a wide spectrum of cancer cells. Relatively, its anticancer activities are about 10-100 times more potent than many well-known anticancer drugs in clinical use. However, the promise of OSW-1 is dampened by its relatively weak in vivo anticancer activity. We hypothesize that the loss of two ester groups on OSW-1 in m

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36

Cardullo, Nunzio. "Synthesis of natural-derived polyphenols as potential anticancer agents." Doctoral thesis, Università di Catania, 2016. http://hdl.handle.net/10761/3785.

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Extracts from plants or other organisms have been used for thousands of years as medicines and today a multitude of researchers continue to be inspired by the astonishing structural variety of natural products to identify potential lead compounds for drug discovery. In the simplest of terms, a natural product is a small molecule (generally with a molecular weight below 3000 Da) that is produced by a biological source; often the term is considered as synonymous for secondary metabolite and natural products research focuses on the biosynthesis and the study of chemical properties and biologica

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37

Younis, Islam Rasem. "In vitro elucidation of the metabolic fate of the anticancer drug busulfan." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5576.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 109 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 92-109).

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38

Min, Junxia. "Sphingolipid metabolic enzymes modulate anticancer drug resistance." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5899.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (March 5, 2007) Vita. Includes bibliographical references.

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39

Fiaux, Hélène. "Development of new anticancer agents based on alpha-mannosidase inhibition /." Lausanne : EPFL, 2007. http://library.epfl.ch/theses/?nr=3793.

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Thèse Ecole polytechnique fédérale de Lausanne EPFL, no 3793 (2007), Faculté des sciences de base SB, Programme doctoral Chimie et Génie chimique, Institut des sciences et ingénierie chimiques ISIC (Laboratoire de glycochimie et de synthèse asymétrique LGSA). Dir.: Sandrine Gerber.

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40

Liaw, Tracy Yun En Children's Cancer Institute Australia for Medical Research Faculty of Medicine UNSW. "Characterisation of novel anticancer agents in childhood acute lymphoblastic leukaemia." Publisher:University of New South Wales. Children's Cancer Institute Australia for Medical Research, 2009. http://handle.unsw.edu.au/1959.4/43558.

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Tubulin-binding agents (TBAs) are employed widely in cancer treatment, including childhood acute lymphoblastic leukaemia (ALL). Despite their success, resistance to TBAs can be a major clinical problem. Mechanisms mediating resistance to TBAs that target the colchicine-binding site on β-tubulin, along with novel therapeutic strategies were investigated. 2-Methoxyestradiol (2ME2) is a multi-targeted TBA active in various cancer types, yet its efficacy and mechanisms(s) of action in haematological malignancies are not well evaluated. To improve understanding of mechanisms(s) of action and drug r

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41

Posakony, Jeffrey Jerard. "The chemistry and evaluation of porphyrin-based potential anticancer agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ34612.pdf.

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42

Patterson, Richard. "Novel organofluorine chemistry : nucleophilic fluorinating agents and potential anticancer compounds." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55525/.

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This thesis covers work investigating the effects of fluorine incorporation on the structure, biological activity, and NMR properties of anticancer chalcones as well as novel methods for the inclusion of fluorinated moieties into organic compounds. The first chapter looks at the use of silanes as carriers of small fluorinated nucleophiles which can be activated by fluoride anion catalysis to deliver such nucleophiles to organic electrophiles such as aldehydes. The synthesis of a group of such silanes and an assessment of their reactivity towards aromatic aldehydes is described. The second and

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43

Pope, Alexandra Jayne. "Supramolecular anticancer agents and their effects on cells and biomolecules." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1336/.

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Metallo-drugs have been highly significant in the development of novel anticancer agents. Supramolecular drug agents allow the design and synthesis of a range of molecular architectures. The work in this thesis has built upon previous knowledge on this subject by undertaking novel biological studies on known metal supramolecular helicates as well as the design of a new helicate in order to improve upon existing drugs. In chapter three, the DNA three-way junction binding of a number of supramolecular cylinders is described. Three-way junction binding is a new mode of DNA recognition and relevan

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44

Johnstone, Timothy Charles. "Developments in the chemistry and nanodelivery of platinum anticancer agents." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91111.

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Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Approximately half of all patients receiving cancer chemotherapy are treated with a platinum-containing drug. Despite this intense clinical use, only three platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of cancer. A number of side effects accompany platinum-based therapy and novel approaches are under investig

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45

Basudhar, Debashree. "NITROGEN OXIDE RELEASING PRODRUGS AS ANTIINFLAMMATORY, ANTICANCER AND CARDIOPROTECTIVE AGENTS." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145745.

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This dissertation focuses on chemical and biological evaluation of diazeniumdiolate based nitrogen oxide releasing prodrugs. Three projects are described. i. Synthesis and biological evaluation of a series of new nitroxyl (HNO) releasing non-steroidal antiinflammatory drugs (NSAIDs) and comparison to related nitric oxide (NO) releasing NSAIDs A series of HNO releasing isopropylamine-based diazeniumdiolate adducts of NSAIDs and the NO releasing diethylamine diazeniumdiolate counterpart were synthesized. The aspirin derivatives were evaluated for antiinflammatory, cardioprotective and anticancer

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46

Govender, Preshendren. "Development of new bioorganometallic metallodendrimers as in vitro anticancer agents." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/8720.

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Includes bibliographical references.<br>The clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study

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47

Kunati, Sandeep Reddy. "DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919.

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48

Long, Kerya. "Development of synthetic α-helix mimetics as potent anticancer agents". Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4871/.

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Protein-protein interactions (PPIs) mediate a number of essential cellular processes and their implication in numerous diseased states - including HIV and cancer - makes them desirable targets for therapeutic intervention. It is however still unclear how to target them, considering their relative lack of defining features. A large proportion of PPIs however involve binding of an α-helix into a hydrophobic cleft on the other protein’s surface and a few key residues located along one helical face have been identified as a recurring and critical pattern for binding. Mimicking the helical core and

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49

Zhang, Jianjun. "Library Synthesis of Anticancer and Antibacterial Agents via Azide Chemistry." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/711.

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Various anticancer and antibacterial agents have been synthesized via azide chemistry by taking advantage of carbohydrate. Starting from the synthesis of 14 glycosyl azides, a library of carbohydrate-oxazolidinone conjugates and a library of carbohydrate-cyclopamine conjugates with biological interests were synthesized based on a highly efficient "click reaction" assisted by sonication. Some of the conjugates have improved solubility and enhanced anticancer activity. A library of neomycin B derivatives with various modifications at the 5" position has been synthesized. Two leads exhibit

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50

Wang, Ertong. "Discovery of anticancer agents from indigenous Australian melicope and sterculia." Thesis, Queensland University of Technology, 2002.

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