Log in

Relevant bibliographies by topics / Anticancer compound / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Anticancer compound.

Dissertations / Theses on the topic 'Anticancer compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Anticancer compound.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

McGinley, Susan. "A New Anticancer Compound from an Ancient Plant." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2010. http://hdl.handle.net/10150/622060.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Rivero-MuÌˆller, Adolfo. "Speciation and reactivity of the antineoplastic copper-based compound : casiopeina II." Thesis, University of Surrey, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301319.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Rothmeier, Andrea. "Anticancer effects and antiangiogenic mechanisms of the marine compound spongistatin 1." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-93090.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Rothmeier, Andrea Silvia. "Anticancer effects and antiangiogenic mechanisms of the marine compound spongistatin 1." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9309/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Pouliwe, Antibe. "Electrochemical Studies of The Interaction Between DNA and a Compound Having Anticancer Properties." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1352.

Full text

Abstract:

Electrochemical method has been used to study the interaction between DNA and the compound N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-N'-(2-imidazoyl)urea having anticancer properties. A DNA modified nanometer-sized gold electrode was prepared by surface modification of a bare gold electrode using cysteamine. These electrodes have been characterized using electrochemical techniques and were used to study the interaction between DNA and the compound. Our results showed an increase in the adsorption peak current and a negative shift of E1/2 in the oxidation of ferroc

APA, Harvard, Vancouver, ISO, and other styles

6

Bertuzzi, Giulio. "Synthesis and functionalization of a lactam-pyrazole molecular scaffold as a promising anticancer compound." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9035/.

Full text

Abstract:

The importance of pyrazole and lactam-based molecules in medical and pharmaceutical fields is underlined by the multitude of active ingredients on trade, such as Sildenafil or Apixaban, by Pfizer. In this work, a synthesis of an organic molecule with promising anticancer activity has been developed. This molecular scaffold is characterized by a δ-lactam-fused pyrazolic core, with a well-known biological activity and amenable of further functionalization. The synthetic strategy adopted for the obtainment of the core was based on a 1,3-dipolar cycloaddition of a nitrilimine with an α,β-unsaturat

APA, Harvard, Vancouver, ISO, and other styles

7

De, Vizcaya Ruiz Andrea M. G. "Distribution, toxicity and mode of action of the novel copper-based anticancer compound, casiopeina II." Thesis, University of Surrey, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310720.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Kamasah, Alexander. "Using Electrochemical Method to Study the Interaction Between DNA and a compound Known to Have Anticancer Property." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1379.

Full text

Abstract:

The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K4Fe (CN)6 was used as a probe to obtain electrochemical information on the electrode surface. A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modifica

APA, Harvard, Vancouver, ISO, and other styles

9

Vidimar, V. "Characterization of the anticancer properties of ruthenium-derived compounds: mode of action, optimization and development of experimental tools." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3423354.

Full text

Abstract:

Platinum-based compounds are widely used anticancer drugs, despite severe side effects and drug-resistance phenomena. Over the past few years, a new class of platinum-free metal-based compounds, called RDCs (ruthenium-derived compounds), has been introduced with the aim of overcoming these issues. RDCs, in particular RDC11, have shown interesting and peculiar biological properties: a good anticancer activity in vivo, a reduced toxicity on healthy tissues and the ability to induce apoptosis through the induction of the CHOP/DDIT3 protein via a DNA-independent mechanism. Indeed, in contrast to p

APA, Harvard, Vancouver, ISO, and other styles

10

Brustolin, Leonardo. "Novel antiblastic Ru(III)-, Cu(II)- and Au(III)-based coordination compounds: from rational design, synthesis and physico-chemical characterization to nanoformulation, targeted delivery and in vitro evaluation." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425843.

Full text

Abstract:

There is an essential contribution of inorganic medicinal chemistry in the pharmacopeia. In particular, platinum-based drugs revolutionized the anticancer chemotherapy, and nowadays they find wide application in the treatment of several solid tumors. Nevertheless, their effectiveness is paralleled with severe side-toxicity and the onset of drug resistance. In order to obtain compounds with a better chemotherapeutic index and increased bioavailability, several metal-based compounds have been designed and investigated in the last decades. On these grounds, we present here the synthesis and chara

APA, Harvard, Vancouver, ISO, and other styles

11

Lima, Karisia Sousa Barros de. "Phytochemical Study of Two Species of Hyptis from Northeast of Brazil: Hyptis carvalhoi Harley and Hyptis crassifolia Mart. ex Benth. and Anticancer Activity of the Isolated Compound." reponame:Repositório Institucional da UFC, 2014. http://www.repositorio.ufc.br/handle/riufc/18345.

Full text

Abstract:

LIMA, Karisia Sousa Barros de. Estudo Fitoquímico de Duas Espécies de Hyptis do Nordeste do Brasil: Hyptis carvalhoi Harley e Hyptis crassifolia Mart. ex Benth. e Atividade Anticâncer dos Compostos Isolados. 2014. 393 f. Tese (Doutorado em química)- Universidade Federal do Ceará, Fortaleza-CE, 2014.<br>Submitted by Elineudson Ribeiro (elineudsonr@gmail.com) on 2016-06-02T18:50:49Z No. of bitstreams: 1 2014_tese_ksblima.pdf: 15717636 bytes, checksum: 462d1018effc4c80bfd29e17576abf17 (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa (jairo@ufc.br) on 2016-07-14T23:21:49Z (GMT

APA, Harvard, Vancouver, ISO, and other styles

12

May, Christopher. "Synthesis of anticancer compounds." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47237.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Sandler, Joel Stuart. "Anticancer compounds from marine invertebrates /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3247792.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Roffey, Jonathan R. A. "The synthesis of indole containing anticancer compounds." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/10935.

Full text

Abstract:

The concept of bioreductive prodrug chemotherapy is introduced in chapter 1. Tumour cell hypoxia is a significant factor in limiting tumour growth control with conventional radiotherapy and some chemotherapeutic agents. Following therapy these cells can repopulate and cause a relapse of the cancer. On the other hand, hypoxia is unique to tumours, and is therefore potentially exploitable. Bioreductive prodrugs are compounds in which a oxygen inhibited redox-based bioactivation step triggers a reaction leading to a lethal intermediate. The concept of bioreductive DNA alkylators and DNA topoisome

APA, Harvard, Vancouver, ISO, and other styles

15

Whibley, Catherine Evelyn. "South African marine compounds as anticancer agents." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/8393.

Full text

Abstract:

Includes bibliographical references (leaves 149-163).<br>Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the establishment of a screening assay using an oesophageal cancer cell line as a model. It was our hope that this screen would allow us to identify compounds which have activity against oesophageal cancer, that could be used as lead agents for f

APA, Harvard, Vancouver, ISO, and other styles

16

Stewart, Lesley Ann. "Synthesis of heterocyclic compounds as potential anticancer agents." Thesis, University of Glasgow, 1996. http://theses.gla.ac.uk/4936/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Magri, Neal Francis. "Modified taxols as anticancer agents." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/53892.

Full text

Abstract:

Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, succinyl, trichloroethyloxycarbonyl or carbonate linked dibenzylidene protected glucosyl groups. The C-7 position was selectively epimerized under free radical conditions and a 2'-epiacetyltaxol was produced via base catalysed epimerization. The C-2' amide became nucleophilic in the presence of base an

APA, Harvard, Vancouver, ISO, and other styles

18

Myburgh, Jolanda. "Synthesis and characterization of novel platinum complexes : their anticancer behaviour." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018621.

Full text

Abstract:

In this dissertation novel non-leaving groups were employed to synthesize platinum complexes which can contribute to the understanding or improvement of anticancer action. These complexes basically consist of (NS)-chelate and amineplatinum complexes. Bidentate (NS)-donor ligands were used as non-leaving ligands in the syntheses of platinum(II) complexes with iodide, chloride, bromide and oxalate anions as leaving groups. These complexes were synthesized and studied since many questions regarding the interaction of sulfur donors and platinum still exists. These relate to thermodynamic and kinet

APA, Harvard, Vancouver, ISO, and other styles

19

Garner, Mark. "Kinetic and mechanistic studies of Cisplatin derivatives with nucleic acid fragments." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306475.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Cunningham, Rachael. "Investigation of Protein Targets of Pt(II) Anticancer Compounds." Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22652.

Full text

Abstract:

Pt(II) based anticancer drugs—cisplatin, carboplatin, and oxaliplatin—are widely used in the treatment of a variety of cancers. Unfortunately, the clinical efficacy of these drugs is currently hindered by the development of undesirable side effects and resistance during treatment. The molecular mechanisms underlying these effects are still unclear. For decades, research has focused on DNA as the main cellular target of Pt(II) compounds. However, there is increasing interest in proteins as alternative targets of Pt(II) and contributors to cytotoxic and resistance mechanisms of cisplatin. In thi

APA, Harvard, Vancouver, ISO, and other styles

21

Bowman, Karen Julia. "Evaluation of novel compounds to modulate the cytotoxicity of anticancer agents in mammalian cells." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246707.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Bouwer, Yolanda. "Novel aspects of platinum-amine coordination compounds: their chemistry and anticancer application." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/d1021052.

Full text

Abstract:

The aim in this thesis, was to synthesize novel platinum coordination compounds, in order to develop compounds with improved anticancer action which could lead to an improved understanding of the mechanism by which they operate and at the same time, improve synthetic methods for their products. The initial work included the development of a novel synthetic method for 1R,2R-diaminocyclohexaneoxalato-platinum(II) (oxaliplatin), by using an essentially non-aqueous solvent medium and direct ligand exchange at elevated temperatures. This was done by a study of the kinetics of the reaction in a vari

APA, Harvard, Vancouver, ISO, and other styles

23

Oosthuizen, Lukas Marthinus. "New platinum coordination compounds : their synthesis, characterization and anticancer application." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018795.

Full text

Abstract:

The aim of this thesis was to investigate the properties of novel platinum compounds with possible potential as anticancer agents, and to determine how their behaviour could lead to a better understanding of the chemistry involved. The final criteria were improvement of their anticancer behaviour. Since many questions are still unanswered as to the role of sulfur in anticancer action, studies were undertaken to synthesize novel platinum(II) complexes having non-leaving groups consisting of a combination of an aromatic nitrogen and thioetherial sulfur capable of forming a five membered ring upo

APA, Harvard, Vancouver, ISO, and other styles

24

Patterson, Richard. "Novel organofluorine chemistry : nucleophilic fluorinating agents and potential anticancer compounds." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55525/.

Full text

Abstract:

This thesis covers work investigating the effects of fluorine incorporation on the structure, biological activity, and NMR properties of anticancer chalcones as well as novel methods for the inclusion of fluorinated moieties into organic compounds. The first chapter looks at the use of silanes as carriers of small fluorinated nucleophiles which can be activated by fluoride anion catalysis to deliver such nucleophiles to organic electrophiles such as aldehydes. The synthesis of a group of such silanes and an assessment of their reactivity towards aromatic aldehydes is described. The second and

APA, Harvard, Vancouver, ISO, and other styles

25

Waheed, Abdul. "Isolation and characterisation of potential anticancer compounds from medicinal plants." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22906/.

Full text

Abstract:

The research work presented in this thesis deals with the anticancer activity of four medicinal plants: 'Caralluma tuberculata' (Asclepiadaceae), 'Fagonia indica' (Zygophyllaceae), 'Solanum surattense' (Solanaceae) and 'Arisaema utile' (Araceae) that originate from the North West and Himalayan regions of Pakistan. Through a bioactivity-guided fractionation approach, the crude and resultant organic fractions were tested on cultured breast cancer cells (MCF-7 and MDA MB-468) and colorectal carcinoma cells (Caco-2) in vitro. Five new compounds out of seven in total were isolated from potent fract

APA, Harvard, Vancouver, ISO, and other styles

26

Da, Silva Liberio Michelle. "Chemical and Biological Investigations of Anticancer Compounds from Australian Ascidians." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/365813.

Full text

Abstract:

Nature is the main source of anticancer agents with about 60% of the current anticancer drugs originating in some way from natural products. Many cytotoxic natural products have been isolated from marine invertebrates. One group of marine animals that have made significant contributions is the tunicates or ascidians. Ascidians belonging to the family Didemnidae are known to be a prolific and rich source of new chemical entities with biological activity. This study was divided into two main components. In the first part, Didemnid ascidians collected from the Great Barrier Reef (GBR) were invest

APA, Harvard, Vancouver, ISO, and other styles

27

Borrelli, S. "CHEMICAL APPROACHES FOR IMPROVING DRUG DELIVERY OF KNOWN ANTICANCER COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229386.

Full text

Abstract:

Different classes of squalene conjugates have been prepared: the first one containing a disulfide bond that, in the presence of glutathione, is able to trigger the release of a drug unit, the second one containing a tripepidyl sequence selectively cleaved by plasmin and also able to release a drug unit, the last one containinf a fluorescein 5(6)isothiocyanate unit. These compounds are able to self-assemble in water and can improve the delivery of active drugs to tumor tissues and can be helpful in the understanding of nanoparticle cellular uptake.

APA, Harvard, Vancouver, ISO, and other styles

28

Louw, Marissa. "New platinum and palladium complexes: their anticancer application." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1016218.

Full text

Abstract:

Novel non-leaving groups were employed in this dissertation to synthesize platinum complexes which can assist in the understanding or improvement of anticancer action. Emphasis was placed on (NS)-chelate and (NN)-chelate platinum complexes. Bidentate (NS)-donor ligands were used as non-leaving ligands in the synthesis of platinum(II) complexes with iodo, chloro, bromo and oxalato groups as leaving groups. These complexes were synthesized and studied since many questions regarding the interaction of sulfur-donors and platinum still exist. These relate to thermodynamic and kinetic factors and th

APA, Harvard, Vancouver, ISO, and other styles

29

Shum, Yuen-ting. "Functionalized platinum (II) and gold (I) acetylide complexes structural and spectroscopic properties and anticancer activities /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38639865.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Botta, Antonio. "Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs." Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/1971.

Full text

Abstract:

2012 - 2013<br>Heterocyles are an essencial class of molecules, assuming a role in many aspect of our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and bioactive compounds including agrochemical products and drugs. In this work we focused on two important class of heterocyclic compounds: carbazoles and NHCs (N-heterocyclic carbenes). Carbazoles, prevalent as structural motifs in various synthetic materials and naturally occurring alkaloids, as is known, have many applications such as optoelectronic materials, conducting polymers and especially as promising

APA, Harvard, Vancouver, ISO, and other styles

31

Abiodun, Badmus Jelili Abiodun. "Holarrhena floribunda leaves as a potential source of bioactive anticancer compounds." University of the Western Cape, 2014. http://hdl.handle.net/11394/4377.

Full text

Abstract:

Cancer is one of the leading causes of morbidity and mortality in developed and developing nations. It is estimated that 86% of new cases and 64% of death due to cancer are from Africa and 13.1 million deaths are estimated to occur worldwide by the year 2030. Cancer death rates have not subsided despite recent advances in cancer drug development and treatment. Present cancer drug regimens are limited due to unpredictable efficiency, severe side effects ,resistance and high cost. Plants provide a vast array of natural compounds such as terpenoids, phenolics and alkaloids with antiproliferative

APA, Harvard, Vancouver, ISO, and other styles

32

Shepherd, S. L. "Pre-clinical evaluation of novel inorganic compounds as potential anticancer therapies." Thesis, University of Huddersfield, 2018. http://eprints.hud.ac.uk/id/eprint/34547/.

Full text

Abstract:

Background: Recent developments in our understanding of the biology of cancer has provided the opportunity to develop targeted agents with more specific pharmacological activity against cancer cells. Despite this shift toward targeted drug discovery, the much hoped-for paradigm shift in cancer treatment has not been realised. Tumour heterogeneity, plasticity and genomic instability are issues that contribute to this problem. One approach to circumvent these issues is to adopt a phenotypic based approach to drug evaluation where compounds with multiple mechanisms of action leading to a desirabl

APA, Harvard, Vancouver, ISO, and other styles

33

Lim, Keng Gat. "Discovery and characterisation of novel anticancer compounds acting on sphingosine kinase." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23882.

Full text

Abstract:

There is a critical need to develop novel anticancer therapeutics. Accumulating evidence has demonstrated that sphingosine kinase (SK) is a promising target for the treatment of cancer. There are two SK isoforms, termed SK1 and SK2. SK phosphorylates sphingosine to form sphingosine-1-phosphate which drives cancer cell proliferation and migration. Therefore, the aims of this project were to discover hit compounds that can be developed into effective chemical tools and/or anticancer drug leads targeting SK. Compounds from both synthetic and natural origins were screened using SK enzymatic assays

APA, Harvard, Vancouver, ISO, and other styles

34

Abiodun, Badmus Jelili. "Holarrhena floribunda leaves as a potential source of bioactive anticancer compounds." University of the Western Cape, 2014. http://hdl.handle.net/11394/4321.

Full text

Abstract:

Philosophiae Doctor - PhD<br>Cancer is one of the leading causes of morbidity and mortality in developed and developing nations. It is estimated that 86% of new cases and 64% of death due to cancer are from Africa and 13.1 million deaths are estimated to occur worldwide by the year 2030. Cancer death rates have not subsided despite recent advances in cancer drug development and treatment. Present cancer drug regimens are limited due to unpredictable efficiency, severe side effects, resistance and high cost. Plants provide a vast array of natural compounds such as terpenoids, phenolics and alka

APA, Harvard, Vancouver, ISO, and other styles

35

Han, Haiyong. "Identification and characterization of G-quadruplex-interactive compounds as anticancer agents /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Musella, Simona. "Design and synthesis of new polycyclic compounds with potential anticancer activity." Doctoral thesis, Universita degli studi di Salerno, 2011. http://hdl.handle.net/10556/140.

Full text

Abstract:

p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, DNA repair, senescence or apoptosis—all of these cellular responses are designed to prevent damaged cells from proliferating and passing mutations on to the next generation. In 50% of human cancers, p53 is defective due usually to somatic mutations or deletions primarily in its DNA-binding domain and, to a lesser extent, to posttranslational modifications such as phosphorylati

APA, Harvard, Vancouver, ISO, and other styles

37

Lee, Daniel E. "Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3809.

Full text

Abstract:

Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds By Daniel E. Lee, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2015 Major Director: Nicholas P Farrell, Ph.D., Professor, Department of Chemistry Platinum anticancer compounds with cis geometry, similar to cisplatin, have been explored to circumvent the cisplatin resistance; however, they were not considered broadly active in c

APA, Harvard, Vancouver, ISO, and other styles

38

Behray, Mehrnaz. "Synthesis, characterisation and biological activity of silicon nanoparticles functionalised by anticancer compounds." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59420/.

Full text

Abstract:

Silicon Nanoparticles (SiNPs) are non-toxic materials particularly suitable for various biomedical applications. They exhibit unique optical properties for use in bioimaging and diagnostic applications. To exploit these aspects, this thesis explores the synthesis, characterisation and biological activity of SiNPs functionalised by anticancer compounds. Thiourea-based compounds have been shown to represent one of the most promising classes of anticancer agents due to their strong inhibitory activity against Epidermal Growth Factor Receptor (EGFR), overexpression of which is observed in common t

APA, Harvard, Vancouver, ISO, and other styles

39

Du, Plessis-Stoman Debbie. "An investigation of the in vitro anticancer properties of selected platinum compounds." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/498.

Full text

Abstract:

This dissertation mainly deals with some biochemical aspects regarding the efficacy of novel platinum anticancer compounds, as part of a broader study in which both chemistry and biochemistry are involved. Various novel diamine and N-S donor chelate compounds of platinum II and IV have been developed in which factors such as stereochemistry, ligand exchange rate and biocompatibility were considered as additional parameters. In the first order testing, each of these compounds was tested with reference to their “killing” potential by comparing their rate of killing, over a period of 48 hours wit

APA, Harvard, Vancouver, ISO, and other styles

40

Barbera, Maria Chiara. "Computer aided design and synthesis of a new anticancer and antiviral compounds." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54328/.

Full text

Abstract:

Among all the recent advances in different but complementary scientific fields, the impressive progress and development of more powerful computational techniques play a key role in drug design. Computer aided design has become indispensable and complimentary to traditional and modern approaches by guiding medicinal chemists to improve and speed the discovery, design, synthesis and optimization of novel active molecules. The present study has been focused on the design of protein-protein and protein-DNA interacting small molecules inhibitors with the support of computational methods. An accurat

APA, Harvard, Vancouver, ISO, and other styles

41

Nair, Shankari. "Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/9805.

Full text

Abstract:

Includes bibliographical references.<br>Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.

APA, Harvard, Vancouver, ISO, and other styles

42

SCATTOLIN, THOMAS. "Palladium organometallic compounds bearing N-Heterocyclic Carbene ligands as promising anticancer agents." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2938813.

Full text

Abstract:

Despite the appearance in the market of platinum compounds with minor side effects than cisplatin (i.e. carboplatin and oxaliplatin), they did not solve the ineffectiveness on some types of tumors, having the same mechanism of action proposed for cisplatin (DNA platination). For this reason, many research groups have focused their attention on the synthesis and determination of the anticancer properties of compounds with metals different from platinum. Among the most investigated metals there are certainly ruthenium and gold and, only recently, palladium. The latter, despite belonging to the s

APA, Harvard, Vancouver, ISO, and other styles

43

TUVERI, ROSSANA. "Identification & characterization of natural and synthetic compounds as new anticancer agents." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266770.

Full text

Abstract:

This thesis collects the work I have done during the three-year PhD Course. During my first year I have started a path that has allowed me to acquire different techniques devoted to set up and maintain primary cell cultures and cancer derived cell lines as well as to evaluate the cytotoxicity of potential novel synthetic inhibitors of human cancer cells. Part of the second and all the third year was spent at the University of Cape Town, South Africa, in the laboratory of prof. Ariel Katz under the supervision of proff. Roger Hunter and Catherine H. Kaschula investigating the anticancer a

APA, Harvard, Vancouver, ISO, and other styles

44

Wrigley, Samantha. "Investigations of the subtle and selective antitumour properties of 2-(4-aminophenyl)-benzothiazole and related compounds." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338529.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Damanhouri, Z. A. "Drug interactions with the anticancer drug aminoglutethimide and related compounds : A study of aminoglutethimide and pyridoglutethimide as inducers and inhibitors of hepatic metabolism." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379192.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Akter, Raushanara. "Isolation and Structural Elucidation of Bioactive Compounds from Bangladeshi Medicinal Plants with a Focus on Novel Anticancer Compounds." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/366507.

Full text

Abstract:

The present study describes the bioactivity guided isolation and structural elucidation of novel anticancer compounds from the Bangladeshi medicinal plant Blumera lacera. At the outset nineteen Bangladeshi medicinal plants were selected and collected from different parts of Bangladesh. Plants underwent preliminary cytotoxicity screening based on their traditional medicinal uses, limited previous research on them, and their availability. The selected plants were extracted with methanol and screened for their cytotoxic potential using the MTT assay against two healthy cell lines (mouse fibroblas

APA, Harvard, Vancouver, ISO, and other styles

47

Yan, Jing, and 严静. "The anticancer properties of gold (III) complexes with tridentate cyclometalated, porphyrinato and glycosylated ligands." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4587265X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Tian, Songhai, and 田松海. "Proteomic and pharmacological analyses of the mechanism of actions of anticancer gold(I) complexes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206471.

Full text

Abstract:

Gold complexes have a long history of being used as therapeutic agents, especially in applications against immune diseases such as rheumatoid arthritis. In 1979, an oral gold(I) drug – auranofin (AuRF, brand name as Ridaura®) – was demonstrated to exhibit anticancer properties. Since then, a considerable number of gold(I) complexes have been reported to show remarkable anticancer activities, but the understanding of their mechanism of actions is limited. In the present study, AuRF and several other anticancer gold(I)-phosphine complexes including AuPEt ([Au(triethylphosphine)Cl]) were demon

APA, Harvard, Vancouver, ISO, and other styles

49

Thomas, Donald S. "Molecular modelling and NMR studies of multinuclear platinum anticancer complexes." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0009.

Full text

Abstract:

[Truncated abstract] The trinuclear anti-cancer agent [(trans-Pt(NH3)3Cl)2{μ-trans-Pt(NH3)2(H2N(CH2)6NH2)2}]4+ (BBR3464 or 1,0,1/t,t,t) is arguably the most significant development in the field of platinum anti-cancer agents since the discovery of cisplatin as a clinical agent more than 30 years ago. Professor Nicholas Farrell of Virginia Commonwealth University was responsible for the development of 1,0,1/t,t,t and an entire class of multinuclear platinum complexes. The paradigm shift that was required in the development of these compounds is based on a simple idea. In order to increase the f

APA, Harvard, Vancouver, ISO, and other styles

50

Botes, Marthinus Gerhardus. "Towards the synthesis of makaluvamine-analogues." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96959.

Full text

Abstract:

Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Cancer is one of the leading causes of death in developed countries and rising fast as a cause of death in developing countries. The increase of cancer prevalence in developing countries can be attributed to westernisation trends, with lifestyle cancers such as colorectal and lung cancer being amongst the most commonly reported malignant neoplasms. This means that the development of novel methods of treatment is essential in combatting this disease in the developing world. Combinational chemotherapy is one of the best candi

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!