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Relevant bibliographies by topics / Anticancer drug synthesis

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Academic literature on the topic 'Anticancer drug synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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Journal articles on the topic "Anticancer drug synthesis"

1

ZURER, PAMELA. "Total synthesis yields anticancer drug." Chemical & Engineering News 75, no. 6 (1997): 7–8. http://dx.doi.org/10.1021/cen-v075n006.p007a.

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Barbero, Margherita, Emma Artuso, and Cristina Prandi. "Fungal Anticancer Metabolites: Synthesis Towards Drug Discovery." Current Medicinal Chemistry 25, no. 2 (2018): 141–85. http://dx.doi.org/10.2174/0929867324666170511112815.

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Background: Fungi are a well-known and valuable source of compounds of therapeutic relevance, in particular of novel anticancer compounds. Although seldom obtainable through isolation from the natural source, the total organic synthesis still remains one of the most efficient alternatives to resupply them. Furthermore, natural product total synthesis is a valuable tool not only for discovery of new complex biologically active compounds but also for the development of innovative methodologies in enantioselective organic synthesis. Methods: We undertook an in-depth literature searching by using chemical bibliographic databases (SciFinder, Reaxys) in order to have a comprehensive insight into the wide research field. The literature has been then screened, refining the obtained results by subject terms focused on both biological activity and innovative synthetic procedures. Results: The literature on fungal metabolites has been recently reviewed and these publications have been used as a base from which we consider the synthetic feasibility of the most promising compounds, in terms of anticancer properties and drug development. In this paper, compounds are classified according to their chemical structure. Conclusion: This review summarizes the anticancer potential of fungal metabolites, highlighting the role of total synthesis outlining the feasibility of innovative synthetic procedures that facilitate the development of fungal metabolites into drugs that may become a real future perspective. To our knowledge, this review is the first effort to deal with the total synthesis of these active fungi metabolites and demonstrates that total chemical synthesis is a fruitful means of yielding fungal derivatives as aided by recent technological and innovative advancements.

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Bazylevich, Andrii, Helena Tuchinsky, Eti Zigman-Hoffman, et al. "Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery." Medicinal Chemistry 15, no. 5 (2019): 537–49. http://dx.doi.org/10.2174/1573406415666181203112220.

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Background: Scientists have extensively investigated curcumin, yielding many publications on treatments of cancer. Numerous derivatives of curcumin were synthesized, evaluated for their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications. Objective: We decided to exploit curcumin as a bioactive core platform for carrying anticancer drugs, which likely possesses a carboxyl moiety for potential linkage to the carrier for drug delivery. Methods: The goal of this work is to develop biolabile multifunctional curcumin platforms towards anticancer drug delivery, including determination of drug release profiling in hydrolytic media, in vitro cytotoxicity, antioxidant properties and blockage of relevant cell survival pathways. Results: We report on a facile synthesis of the bioactive multifunctional curcumin-based platforms linked to a variety of anticancer drugs like amonafide and chlorambucil, and release of the drugs in a hydrolytic environment. The leading curcumin-based platform has presented antioxidant activity similar to curcumin, but with much more potent cytotoxicity in vitro in agreement with the augmented blockage of the NF-kB cell survival pathway. Conclusion: The approach presented here may prove beneficial for bioactive curcumin-based delivery applications where multiple drug delivery is required in a consecutive and controlled mode.

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Duong, Vu Binh, Pham Van Hien, Tran Thai Ngoc, Phan Dinh Chau, and Tran Khac Vu. "A Simple Synthesis of the Anticancer Drug Altretamine." Letters in Organic Chemistry 17, no. 8 (2020): 628–30. http://dx.doi.org/10.2174/1570178617666200210111041.

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A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

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Meegan, Mary J., and Niamh M. O’Boyle. "Special Issue “Anticancer Drugs”." Pharmaceuticals 12, no. 3 (2019): 134. http://dx.doi.org/10.3390/ph12030134.

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The focus of this Special Issue of Pharmaceuticals is on the design, synthesis, and molecular mechanism of action of novel antitumor, drugs with a special emphasis on the relationship between the chemical structure and the biological activity of the molecules. This Special Issue also provides an understanding of the biologic and genotypic context in which targets are selected for oncology drug discovery, thus providing a rationalization for the biological activity of these drugs and guiding the design of more effective agents. In this Special Issue of Pharmaceuticals dedicated to anticancer drugs, we present a selection of preclinical research papers including both traditional chemotherapeutic agents and newer more targeted therapies and biological agents. We have included articles that report the design of small molecules with promising anticancer activity as tubulin inhibitors, vascular targeting agents, and topoisomerase targeting agents, alongside a comprehensive review of clinically successful antibody-drug conjugates used in cancer treatment.

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Kumar, Ajay, Gunjan Bisht, Nazia Siddiqui, Sheerin Masroor, Sameena Mehtab, and M. G. H. Zaidi. "Synthesis of Magnetic Hydrogels for Target Delivery of Doxorubicin." Advanced Science, Engineering and Medicine 11, no. 11 (2019): 1071–74. http://dx.doi.org/10.1166/asem.2019.2452.

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Magnetic hydrogels are the stimuli responsive polymeric networks with potential applications in protein purification, cell separation and target drug delivery. In the present investigation, efforts are made on synthesis and characterization of magnetic hydrogels from poly(N-isopropylacrylamide) for onwards application in target delivery of an anticancer drug Doxorubicin. Formation of reaction products was ascertained through diversified spectral methods. Ultraviolet spectra reveal in vitro biocompatibility of Doxorubicin that imparts sustained delivery up to 72 hrs at pH 7.2 ± 0.2 under ambient conditions. The present investigation provides an inexpensive method of synthesis of magnetic hydrogels suitable for magnetically derived delivery of anticancer drugs.

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Sun, Zhi-Gang, Zhi-Na Li, Bao-Chan Yang, and Liang-Hui Zhao. "Design and Synthesis of Novel Anticancer Peptide Nanoparticles." Journal of Drug Delivery and Therapeutics 10, no. 4 (2020): 102–7. http://dx.doi.org/10.22270/jddt.v10i4.4156.

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Cancer has now become a common disease affecting human health. Existing cancer treatment drugs can no longer meet the growing needs of cancer patients, and the emergence of anticancer drug resistance has exacerbated this phenomenon. By designing and synthesizing new anticancer peptide nanoparticles and studying their anticancer effects, new strategies for cancer treatment may be obtained. Novel anticancer peptides are synthesized by adding basic amino acids and solid-phase synthesis technology, and their structural information is determined by mass spectrometry. Nanoparticles of anticancer peptide were synthesized by nano-self-assembly technology. Two novel anticancer peptides exhibited anticancer activity, one of which was assembled into nanoparticles. The theoretical isoelectric points of the modified SZG3 and SZG5 are all greater than physiological pH, and will be positively charged under physiological conditions. The estimated half-life of SZG3 and SZG5 is significantly extended (30h), which is beneficial to increase the efficacy and reduce toxic and side effects. SZG3 and SZG5 have a good inhibitory effect on tumor cells and have low toxicity to normal cells. Keywords: anticancer peptide, study, design, cancer, nanoparticles

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Savinkova, A. V., E. M. Zhidkova, L. R. Tilova, et al. "VARIANTS AND PERSPECTIVES OF DRUG REPURPOSING FOR CANCER TREATMENT." Siberian journal of oncology 17, no. 3 (2018): 77–87. http://dx.doi.org/10.21294/1814-4861-2018-17-3-77-87.

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Recently many new approaches for repurposing or repositioning of the clinically used drugs have been developed. Drug repurposing allows not only to use known schemes for the synthesis of biologically active compounds, but also to avoid multiple studies that are necessary for drug approval process – analysis of pharmacokinetics, carcinogenicity, acute and chronic toxicity, including cardiotoxicity, nephrotoxicity, allergenicity etc. It makes possible to reduce the number of experimental studies as well as costs of investigations. In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and search for new applications of known anticancer drugs for the treatment of different cancer types. Scientific rationale for the search of the compounds with potential anticancer properties among drugs with different applications is based on the multiple cross-talks of signaling pathways, which can inhibit cell proliferation. Modern advances in genomics, proteomics and bioinformatics, development of permanently improving databases of drug molecular effects and high throughput analytical systems allow researchers to analyze simultaneously a large bulk of existing drugs and specific molecular targets. This review describes the main approaches and resources currently used for the drug repurposing, as well as a number of examples.

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Delasoie, Joachim, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic, and Fabio Zobi. "Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes." Pharmaceutics 12, no. 5 (2020): 480. http://dx.doi.org/10.3390/pharmaceutics12050480.

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Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B12-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial–temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient.

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Sharma, Naveen, Ganesh Bhatt, and Preeti Kothiyal. "Gold Nanoparticles synthesis, properties, and forthcoming applications : A review." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (2015): 13–27. http://dx.doi.org/10.30750/ijpbr.3.2.3.

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Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characteristics. AuNPs can be conjugated with ligands, imaging labels, therapeutic drugs and other functional moieties for site specific drug delivery application. In this present review we are discussing the synthesis, properties, and forthcoming applications of gold nanoparticle (AuNPs) which is the most studied among all other metallic-nanoparticles. Here our main focus is to explain the AuNPs application in cancer treatment. AuNPs provides non-toxic carrier system for pharmaceutical drug and gene delivery applications. Currently various anticancer drugs are available but these are cause the necrosis of cancerous cell as well as normal cells. AuNPs cause the necrosis of only cancer cells therefore we can utilize it as a delivery vehicle as well as anticancer agent

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Dissertations / Theses on the topic "Anticancer drug synthesis"

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Ratcliffe, Andrew J. "Synthesis of non-mutagenic anticancer drugs." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378598.

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Walsh, Andrew J. "Synthesis of triplex-forming oligonucleotide conjugates of the anticancer drug temodal." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10970/.

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Covalent attachment of the anticancer drugs temozolomide (Temodal) and mitozolomide to triplex-forming oligonucleotides (TFOs) is a potential way of targeting these alkylating agents to specific gene sequences to maximise site-selectivity. In this work, polypyrimidine TFO conjugates of both drugs were synthesised and targeted to duplex DNA in an attempt to effect site-specific alkylation of guanine residues. Concurrently, in an attempt to enhance the triple helix stability of TFOs at neutral pH, the thermal stabilities of triplexes formed from TFOs containing isoguanine, 2-O-benzyl- and 2-O-allyl-adenine were evaluated. A novel cleavage and deprotection procedure was developed which allowed for the solid phase synthesis of the base-sensitive TFO-drug conjugates using a recently developed silyl-linked controlled pore glass (SLCPG) support. Covalent attachment of either temozolomide or mitozolomide at the 5'-end of TFO conjugates caused no destabilisation of the triplexes studied. The synthesis of a phosphoramidite derivative of mitozolomide enabled direct incorporation of this reagent into a model sequence during DNA synthesis. After cleavage and deprotection of the TFO-drug conjugate, the 5'-end mitozolomide residue was found to have decomposed presumably as a result of ring-opening of the tetrazinone ring. The base-sensitive antibacterial and antitumour agent, metronidazole, was also successfully incorporated at the 5'-end of the oligonucleotide d(T8) using conventional methods. Two C2-substituted derivatives of 2'-deoxyadenosine containing 2-O-benzyl and 2-O-allyl groups were synthesised. Hydrogenolysis of the 2-O-benzyl analogue provided a useful route, amenable to scale-up, for the synthesis of the rare nucleoside 2'-deoxyisoguanosine (isoG). Both the 2-O-allyl and 2-O-benzyl derivatives were incorporated into TFO sequences using phosphoramidite methodology. Thermal melting experiments showed that the 2-O-allyl and 2-O-benzyl groups caused marked destabilisation of the triple helices studied, in contrast to hexose-DNA duplexes, where aralkyl substituents caused significant stabilisation of duplexes.

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Liang, Yi. "Design, Synthesis and Screening of Peptidomimetics for Anticancer and Antiviral Drug Candidates." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6111.

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The high demand of novel peptide and peptidomimetics based on the amount of genomic and proteomic data need be matched by synthesis and screening. The design and synthesis of peptide and peptidomimetics are so important because the peptide and protein-protein interaction play a key role in molecule recognition and signaling. The modified peptides have better stability and pharmacokinetic properties which may be guided by rational design and molecular modeling. Now many organic and medicinal chemists have chosen peptide and peptidomimetics as potential drug candidates for many targets. In this dissertation, research efforts in design and synthesis of cyclic peptides with stabilized secondary structure have been investigated. Cyclization of linear peptides may restrict the number of available conformations which may improve the affinity attaching to the target. In this study, different beta turn linkers have been designed and synthesized to achieve more stable cyclic peptides with beta-sheet structures. Based on different beta turn linkers, analogs of cyclic peptides have been synthesized and screened. The structure activity relationships (SAR) of these cyclic peptide analogs have been studied. In chapter three, analogs of peptidomimetic inhibitors have been designed and synthesized. These peptide analogs are targetingHuman Rhinovirus (HRV) and Coronavirus (CoV) by inhibiting the cysteine protease. The docking and modeling studies have been shown. The structures of this kind of inhibitors include five fragments. The warhead provides the activity, which can covalently react with the thiol of cysteine protease and permanently eliminate its proteolytic activity. The warhead is linked to a peptide backbone including the other four parts that are designed to position the warhead where it can specially react with the critical thiol of the cysteine protease active site. The side chain of each amino acid has been optimized to achieve better solubility and permeability. We successfully synthesized some compounds with good potency.

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4

Xia, Long. "Design and Synthesis of Doxorubicin Conjugated Gold Nanoparticles as Anticancer Drug Delivery System." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/81256.

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Doxorubicin is one of the most widely used and effective anticancer agents to treat a wide spectrum of tumors. But its success in cancer therapy is greatly compromised by its cumulative dose-dependent side effects of cardiotoxicity and tumor cell resistance. For the purpose of addressing these side effects, a gold nanoparticles-based anticancer drug delivery system was designed. Five novel thiolated doxorubicin analogs were designed and synthesized and their biological activities have been evaluated. These doxorubicin analogs and the poly(ethylene glycol) (PEG) stabilizing ligands were conjugated to gold nanoparticles via formation of a gold-thiol bond. The systems were evaluated in vitro and in vivo, and the results show that controlled drug release can be achieved either by acidic conditions or by reducing agents in cancer cells, depending on the design of the thiolated drug construct. The overall drug delivery system should achieve enhanced drug accumulation and retention in cancer cells and favorable drug release kinetics, and should demonstrate therapeutic potential and the ability to address some of the current problems of doxorubicin in cancer therapy.<br>Master of Science

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Kailasan, Arunvel. "Synthesis and characterization of novel temperature-responsive dendritic PEG-PDLLA star polymers for drug delivery." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1630.

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This study describes a novel thermoresponsive dendritic polyethylene glycol-poly(D, L-lactide) (PEG-PDLLA) core-shell nanoparticle with potential for drug delivery and controlled release. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG to Starburst™ polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA, in which PEG chain length (i.e., MW=1500, 6000 or 12000 Dalton) was varied; however, the feeding molar ratio of DLLA monomers to the overall PEG repeat units on the dendrimer surface was kept at 1:1. Linear PEG-PDLLA copolymers were also syntheiszed under the same condition and used as control. According to our results, dendritic PEG-PDLLA in aqueous phase could self-assemble into spherical aggregates and the size of spherical aggregates increased with PEG chain length increase. Further, spherical aggregates made of dendritic PEG-PDLLA exhibited magnified temperature-dependence in terms of solubility change and dimension expansion as compared to linear PEG-PDLLA. The most significant size expansion was observed in particles made of dendritic PEG (12000)-PDLLA, which was twice as much as that of particles made of linear PEG (12000)-PDLLA. Water insoluble antitumor drug camptothecin (CPT) was used as a model drug for encapsulation and release studies. Spherical aggregates encapsulated more CPT when dendritic PEG-PDLLA had longer PEG-PDLLA chain and/or when temperature was elevated to body temperature. This study demonstrated that nanoscale clustering PEG-PDLLA through dendrimers magnified the thermo-sensitivity of PEG-PDLLA. Successful development of such a new particulate system made of dendritic PEG-PDLLA with an expandable dimension in response to temperature change generated a new direction for designing stimuli-responsive materials.

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Tran, Khanh Tuan. "Interaction of topoisomerase II-targeted anticancer agents with the doxorubicin cardioprotective drug dexrazoxane, and synthesis of a dexrazoxane analog." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/MQ41640.pdf.

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Huntsman, Andrew C. "Development of Phyllanthusmin Derivatives as Anticancer Agents: Pharmacological Optimization and Mechanistic Insight." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156338449662965.

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8

Yeung, Kap-Sun. "Synthetic studies on scytophycin C/total synthesis of swinholide A." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272786.

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9

Mitchinson, Andrew. "New synthetic routes to polyamines and their use in receptor studies." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481468.

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10

Liu, Tong. "The synthesis of novel anticancer drugs." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/4464/.

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Our studies on the synthesis and biological evaluation of novel anticancer drugs consist of three research areas; namely, synthesis of Mitogen Activated Protein (MAP) kinase inhibitors, Checkpoint (Chk1) inhibitors and nordihydroguaiaretic acid (NDGA) analogues. The first research area involved synthesis of MAP kinase inhibitors. MAP kinases are a family of serine I and threonine II kinases which can act together to generate a process of phosphorylation events within the cell signalling pathway leading eventually to cell division. The compounds made in this project were specifically designed to target the stress related kinases, a MAP kinase pathway which controls the expression of genes involved in cell proliferation. The stress related kinases are known to have serine or threonine joined to a proline III residue. In an attempt to prepare selective inhibitors of stress related kinases, compounds of types IV and V were deigned in which a conformationally restricted serine analogue is joined to L-proline via an amide link in one of two possible ways. Examples of these two sets of compounds were synthesised and those that were tested by Professor David Gillespie at the Beatson Institute for Cancer Research, Glasgow were shown not to be inhibitors of these kinases. (Fig. 1144A) The second research area concentrated on the checkpoint signalling pathway. Components in the DNA damage checkpoint signalling pathway such as ChK1 could be potential targets for chemical intervention. Caffeine VI and pentoxifylline VII have been shown to sensitise p53-deficient tumour cells to killing by DNA damage. We envisaged that the xanthine derivatives, caffeine VI and pentoxifylline VII might also disrupt the G2 checkpoint by preventing activation of Chk1. To test his hypothesis, a range of xanthine derivatives shown below were prepared by alkylation of theophylline VIII or theobromine IX. (Fig. 1144B) The biological evaluation of these xanthine derivatives by Professor Gillespie revealed that three of these compounds, X, XI and XII, suppressed G2/M arrest very effectively. All three active compounds possess a long aliphatic chain that provides a large degree of flexibility to the structures. The long aliphatic chains could bind to a hydrophobic pocket in the enzyme’s active site that might confer selectivity on the compounds. (Fig. 1144C) The third area, synthesis of NDGA analogues, was the major part of the synthetic work. NDGA XIII is known to be a selective inhibitor of lipoxygenase and blocks small cell lung cancer growth in vitro and in vivo. In addition to its lipoxygenase activity, NDGA was demonstrated to inhibit c-kit, a tyrosine kinase that has been observed preferentially in SCLC. The main drawbacks to the use of NDGA in cancer treatment are its poor solubility and moderate potency. Therefore chemical modifications are required to provide better compounds for clinical use. Preliminary work in our group was performed by McDonald and Macleod. They synthesised a range of analogues of NDGA which were tested for their activity in vitro by Professor Michael Seckl at the Medical Oncology Department of Hammersmith Hospital, London. Improved potency over NDGA for new analogues with 4-6 atoms between the two aromatic rings was observed. Furthermore introduction of an amide linkage between the two aromatic residues resulted in NDGA analogues which are more active than NDGA. Based on these preliminary results, the structural modifications proposed for this project focused on three areas. The main programme of research was drug solubilisation of new analogues which have higher potency than NDGA for in vivo work. The second area of study sought to introduce position variations of the amide linkage between the two aromatic residues. The third area of work involved modification of the substituents on the two aromatic rings. (Fig. 1144D) A range of NDGA analogues was successfully synthesised and evaluated for anticancer activity in vitro. Compounds XIV and XV were confirmed as lead compounds which are ten times more active than NDGA. Compound XIV was successfully transformed into a water soluble form XVI which is now available for in vivo work. In addition NDGA was converted into a water soluble form which was more potent than NDGA in vitro. Moreover a NDGA analogue XVII with no free hydroxy groups was found to be as active as NDGA, which was an unexpected discovery. (Fig. 1144E)

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Books on the topic "Anticancer drug synthesis"

1

Crump, J. P. Synthesis of the anticancer drug aminoglutethimide. UMIST, 1997.

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Atta-ur-Rahman and Khurshid Zaman, eds. Topics in Anti-Cancer Research: Volume 8. BENTHAM SCIENCE PUBLISHERS, 2019. http://dx.doi.org/10.2174/97898114043821190801.

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Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies targeting cancer stem cells for the treatment of different types of cancers, including myeloma and renal cell cancer. The diversity of researches and topics published in this eBook Series will be valuable to cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer targets for the treatment of various cancers. The topics covered in the eighth volume of this series are as follows: Novel Drugs for Multiple Myeloma Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs Recent Progress of Phenazines as Anticancer Agents Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges

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Payne, Emma Kate. The synthesis and characterization of novel platinum and palladium diimene compounds for use as anticancer drugs and CO2 reduction catalyst. 2003.

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Book chapters on the topic "Anticancer drug synthesis"

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Chang, K. C., P. S. Wu, J. M. Yeh, and M. F. Hsieh. "Synthesis and Characterization of Novel Self-assembly and Ph-Sensitive Anticancer Drug Carriers: (PAMAM-AP)-Modified PEG Loading with DOX." In IFMBE Proceedings. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02913-9_178.

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Witczak, Zbigniew J., Ajay Bommareddy, and Adam L. VanWert. "Pederin, Psymberin and the Structurally Related Mycalamides: Synthetic Aspects and Biological Activities." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_32.

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Brocksom, Timothy J., Kleber T. de Oliveira, Marco A. B. Ferreira, and Bruno M. Servilha. "Essential Oils as Raw Materials in the Synthesis of Anticancer Drugs." In Bioactive Essential Oils and Cancer. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19144-7_4.

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Naylor, M. A. "Synthesis, Properties and Potential Mechanism of Action of Fused Pyrazine mono-N-Oxide Bioreductive Drugs." In Novel Approaches in Anticancer Drug Design. S. Karger AG, 1995. http://dx.doi.org/10.1159/000424081.

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Banik, Bimal Krishna, and Biswa Mohan Sahoo. "Green synthesis and biological evaluation of anticancer drugs." In Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-817592-7.00019-8.

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Threadgill, Michael D., Martin Scobie, Pauline J. Wood, and Sean P. Bew. "Synthesis and Preliminary 11B NMR Biodistribution Studies of Nitroimidazole-Carboranes Designed for Boron Neutron Capture Therapy." In Novel Approaches in Anticancer Drug Design. S. Karger AG, 1995. http://dx.doi.org/10.1159/000424082.

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Ilango, K., Baburaj Baskar, and Sankaranarayanan Murugesan. "Green chemistry assisted synthesis of natural and synthetic compounds as anticancer agents." In Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-817592-7.00001-0.

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"Combinatorial Approaches in Anticancer Drug Discovery: Recent Advances in Design and Synthesis." In Frontiers in Medicinal Chemistry - (Volume 1), edited by Sukanta Bhattacharyya. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805204210401010215.

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Fairlie, David, and Robert Reid. "Parallel Synthesis Of Anticancer, Antiinflammatory, And Antiviral Agents Derived From L- And D-amino Acids." In High-Throughput Lead Optimization in Drug Discovery. CRC Press, 2008. http://dx.doi.org/10.1201/9781420006964.ch7.

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"Parallel Synthesis of Anticancer, Antiinammatory, and Antiviral Agents Derived from l- and d-Amino Acids." In High-Throughput Lead Optimization in Drug Discovery. CRC Press, 2008. http://dx.doi.org/10.1201/9781420006964-10.

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Conference papers on the topic "Anticancer drug synthesis"

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Wang, Ying, Jiawen Hu, and Jiannan Xiang. "Targeted Anticancer Drug Delivery System: Design and Synthesis." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4382094.

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Gera, Lajos, Daniel C. Chan, Paul A. Bunn, Jr., and Robert S. Hodges. "Design and Synthesis of Small Molecule Peptidomimetics as Broad Spectrum Anticancer Drug Candidates." In The Twenty-Third American and the Sixth International Peptide Symposium. Prompt Scientific Publishing, 2013. http://dx.doi.org/10.17952/23aps.2013.192.

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CORTES-GARCIA, CARLOS, Rocío Gamez-Montaño, and Luis Chacón- García. "Synthesis of novel complex conjugated imines containing a fragment of the anticancer drug imatinib ." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04735.

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Gutierrez, Elaine, Sumit Sahni, Des R. Richardson, and Patric J. Jansson. "Abstract A20: Concomitant induction of autophagosome synthesis and impairment of lysosomal integrity by the redox-active anticancer drug Dp44mT converts autophagy into a detrimental process." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-a20.

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Lehar, Joseph. "Abstract IA16: Large-scale systematic explorations of single and combined drug responses to suggest anticancer drugs and overcome resistance." In Abstracts: AACR Precision Medicine Series: Synthetic Lethal Approaches to Cancer Vulnerabilities - May 17-20, 2013; Bellevue, WA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.pms-ia16.

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Discher, Dennis E., and Paul Dalhaimer. "Soft Filaments Circulate Longer Than Spherical Particles - Shape Effects in Flow and Drug Delivery." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176746.

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Abstract:

Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we use highly stable, polymer micelle assemblies known as ‘filomicelles’ to compare the transport and trafficking of these flexible filaments to spheres of similar chemistry. In rodents, filomicelles persisted in the circulation up to 1 week after intravenous injection. This is about ten-fold longer than their spherical counterparts and more persistent than any known synthetic nanoparticle. With cells and in fluid flow conditions, spheres and short filomicelles are taken up by cells more readily than longer filaments because the latter are extended by the flow. Preliminary results further demonstrate that filomicelles can effectively deliver the anticancer drug paclitaxel and shrink human-derived tumors in mice. These findings redefine what is ‘nano’ for circulating vehicles and perhaps also lend insight into shape advantages of natural filoviruses.

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ADLI, Mazhar. "Abstract A08: in vivo CRISPR screening enables precision medicine by identifying novel drug combinations and modeling anticancer drug sensitivity." In Abstracts: AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; January 4-7, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-8514.synthleth-a08.

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Jaiswal, Alok, Prson Gautam, Jing Tang, Krister Wennerberg, and Tero Aittokallio. "Abstract A26: Prediction of synergistic anticancer drug combinations by integrating chemical and genetic screens." In Abstracts: AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; January 4-7, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-8514.synthleth-a26.

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Suárez-Castro, Abel, Luis Chacón- García, CARLOS CORTES-GARCIA, and Rocío Gamez-Montaño. "Docking studies of 1,5-disubtituted tetrazoles analogs of the anticancer drug imatinib as probable inhibitors of the ABL kinase and the T315I mutant kinase ." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04734.

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Punganuru, Surendra R., Hanumantharao Madala, and Kalkunte S. Srivenugopal. "Abstract 3664: Hybrid anticancer drugs: Synthesis of a combretastatin-piperlongumine analog with mutant p53 reactivation and antimicrotubule properties." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3664.

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Reports on the topic "Anticancer drug synthesis"

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Biswas, Kaustav, and Samuel J. Danishefsky. Synthesis of Epothilone Analogs: Toward the Development of Potent Anticancer Drugs. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada409475.

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