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Relevant bibliographies by topics / Anticancer drug treatment

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Dissertations / Theses

Academic literature on the topic 'Anticancer drug treatment'

Author: Grafiati

Published: 14 March 2023

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Dissertations / Theses on the topic "Anticancer drug treatment"

1

Fumagalli, G. "DRUG-CONJUGATES FOR SELF-ASSEMBLED NANOPARTICLES IN ANTICANCER TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/542496.

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This dissertation is an overview on the functionalization of known anticancer compounds in order to form different drug-conjugates able to self-assemble in water to form nanoparticles. This approach is useful to improve the drug delivery properties and pharmacokinetic profile of anticancer drugs. All the described conjugates, except for the ones illustrated in chapter 5, have the same general structure: the anticancer drug is connected to the self-assembly inducer trough a linker. Chapter 1 regards a general introduction about nanomedicine, the advantages of the use of nanotechnology-based s

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2

Golovko, Olga. "The screening for novel proteasome inhibitors as a treatment of cancer using IncuCyte FLR and fluorometric microculture cytotoxicity assay." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160700.

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The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation. Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment. The study aimed to test vari

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3

Brazzale, Chiara. "Gold nanoparticle surface tuning for multimodal treatment of cancer." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424441.

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In the last decades colloidal decorated gold nanoparticles (GNPs) have been studied as platform for drug and gene delivery, for diagnostic and other biomedical applications. These metal nanoparticles are intriguing because of their unique physico-chemical properties that can be exploited for multimodal and combined treatment of cancer. In the present thesis work gold nanoparticles were decorated with a targeting ligand (Folate-PEG) to combine an active and a passive targeting aiming to enhance the selective accumulation within the tumour site. Deep studies have been done to investigate the eff

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4

Pardella, Elisa. "Therapy-induced stromal senescence promotes prostate cancer progression and aggressiveness." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128061.

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Although chemotherapy still represents the gold-standard treatment option for cancer cure, it often results in several long-term negative side effects, including cancer relapse and acquired resistance to the therapy. Docetaxel is the preferred anticancer drug for several tumor types, including metastatic castrate-resistant prostate cancer. However, it exhibits only modest efficacy and many patients who received Docetaxel treatment experience tumor progression and chemotherapy insensitivity. Therefore, identifying the molecular mechanisms that associate anticancer therapy with its negative byst

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5

Marwah, Mandeep Kaur. "Development of a novel deformable liposomal formulation for the dermal drug delivery of anticancer agents in the treatment of non-melanoma skin cancers." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37493/.

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The incidence of skin cancer is increasing and conventional treatments such as surgery are not suitable for all patients. This study aimed to develop an elastic liposomal gel to be applied directly to the tumour for the controlled release of anti-cancer agents to the dermal layer. The proposed anti-cancer flavonoids EGCG and naringenin as well as the novel potent cytotoxic agent MTL-004 were loaded into the bilayer of liposomes. Furthermore, aqueous gels HEC and HPMC were investigated as carriers for the liposomes to be applied topically. Liposomes loaded with either Tween 80, Tween 20 or sodi

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6

Shaw, Yeng-Jeng. "Small molecule-based drug design of anticancer agents that target protein kinase B / AKT, Bcl-xL and DNA methyltransferases for the treatment of prostate cancer." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1128693982.

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7

Yaacoub, Katherine. "c-FLIP as a potent anticancer target : Enhancement of cancer cell apoptosis by compounds identified through virtual screening." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B011/document.

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FLIP (FLICE inhibitory protein) est une protéine anti-apoptotique qui a des identités de séquence partagées avec la protéine pro-apoptotique caspase-8. FLIP se trouve en compétence avec caspase-8 pour se fixer sur la protéine adaptatrice FADD, ce qui empêche l’activation de caspase-8 bloquant ainsi l'apoptose. Lors du développement des molécules interférant avec des protéines anti-apoptotiques, la recherche d'inhibiteurs de la protéine FLIP qui est surexprimée dans un très grand nombre de cancers, a échoué. Cela s'explique en partie par le fait que peu d'information structurelle de FLIP est ac

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8

Serafin, Antonio Mendes. "Cell biological responses of prostatic tumour cell lines to irradiation and anticancer drugs." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53321.

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Thesis (PhD)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: The "classic" prostate cell lines, DU145, PC-3 and LNCaP, have served as a valuable cell biological model for research into prostate cancer. However, their relevance may be limited because they derive from metastatic, and not from primary normal and tumour epithelium. The cell lines (1532T, 1535T, 1542T, 1542N and BPH-l) have been derived from primary benign and malignant human tumour prostate epithelium and may be more representative. Using these cell lines I have examined the role of basic cell damage responses (repair

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9

Booker, Victoria. "Investigating the occurrence and fate of anticancer drugs in sewage treatment works and the wider aquatic environment." Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/82556/.

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The occurrence of pharmaceuticals in wastewater and the wider environment is of growing concern. This thesis focuses on anticancer drugs - a group of biologicallypotent and often recalcitrant set of chemicals whose fate and impact on the wider freshwater environment is poorly studied. The aims of this thesis were to prioritise a group of anticancer drugs for environmental monitoring programmes (from the many drugs in use), based on their consumption and fate during wastewater treatment; to undertake a national and regional survey of two commonly used anticancer drugs, cyclophosphamide (CP) and

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10

Kotadia, Nayna. "A Study on the Protein Interaction with Different Platinum Compounds." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/8.

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Since the discovery of anti-tumor activity of cisplatin in 1960, significant progress has been made in treating metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like methionine, histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of react

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