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Dissertations / Theses on the topic 'Anticancer drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Apps, MIchael Garry. "Platinum anticancer drugs and drug delivery systems." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14409.

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In this thesis two different ways to improve platinum-based chemotherapy were investigated. The first was through the use of a new slow release clay-based drug delivery vehicle and the second through the design and synthesis of novel dinuclear platinum complexes. For the clay-based drug delivery research, the platinum anticancer complex [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)] chloride, PHENSS, was loaded into montmorillonite (MMT) clay. The PHENSS was found to be incompletely burst released from the MMT. The MMT also had a negative effect on the in vitro cytotoxicity of P

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2

Kozlowska, Hanna. "Interaction of dexrazoxane with anticancer drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/MQ32158.pdf.

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3

Tao, Zhimin. "Analysis of cytotoxicity of anticancer drugs." Related electronic resource:, 2007. http://proquest.umi.com/pqdweb?did=1407688361&sid=4&Fmt=2&clientId=3739&RQT=309&VName=PQD.

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4

Liu, Tong. "The synthesis of novel anticancer drugs." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/4464/.

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Our studies on the synthesis and biological evaluation of novel anticancer drugs consist of three research areas; namely, synthesis of Mitogen Activated Protein (MAP) kinase inhibitors, Checkpoint (Chk1) inhibitors and nordihydroguaiaretic acid (NDGA) analogues. The first research area involved synthesis of MAP kinase inhibitors. MAP kinases are a family of serine I and threonine II kinases which can act together to generate a process of phosphorylation events within the cell signalling pathway leading eventually to cell division. The compounds made in this project were specifically designed t

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5

Song, Di. "Bladder tissue pharmacokinetics of anticancer drugs /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308433249.

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6

Ratcliffe, Andrew J. "Synthesis of non-mutagenic anticancer drugs." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378598.

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7

Pettersson, Hanna Ilse. "Quinolinequinones as anticancer agents." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249038.

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8

Wang, Shining. "DRUG DEVELOPMENT OF TARGETED ANTICANCER DRUGS BASED ON PK/PD INVESTIGATIONS." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/2535.

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Pharmaceutics<br>Ph.D.<br>EGFR inhibitors, such as gefitinib, are examples of targeted anticancer drugs whose drug sensitivity is related to gene mutations that adds a pharmacogenetic [PG] dimension to any pharmacokinetic [PK] and pharmacodynamic [PD] analysis. The goal of this project was to characterize the PK/PD properties of gefitinib in tumors and then apply these results to design rational drug design regimens, and provide a foundation for future studies with EGFR inhibitors. Progressions of in vitro and in vivo studies were completed to understand the PK and PD behavior of gefitinib. In

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9

Leczkowska, Anna. "Non-covalent DNA-binding ruthenium anticancer drugs." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1695/.

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The research work described in this thesis concerns metal-based anticancer drugs with an emphasis on non-covalent DNA-binding supramolecular assemblies. The project involves the preparation of a series of mono- and bi-metallic ruthenium complexes with a primary focus on fluorescent dinuclear triple-stranded helicates with different structural topographies. Emphasis is then directed towards an investigation of the DNA binding characteristics of these molecules and an evaluation of their anticancer properties in human cancer cell lines. Attention is brought to the significance that the cylinder-

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10

Yarema, Kevin J. (Kevin Jon). "Cellular responses to platinum-based anticancer drugs." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/33495.

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11

Matkar, Smita S. "Mechanism of action of potential anticancer drugs." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2368.

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Traditionally, inoperable or metastatic cancers have been treated by causing massive DNA damage in order to induce self-destruction (apoptosis) of the rapidly multiplying cancer cells. Initially, this strategy works for many cancers, in particular those which express normal p53 tumor suppressor protein. However, most cancers eventually aquire mutations in either p53 or other signaling molecules and fail to initiate apoptosis in response to severe DNA damage. During this study three types of compounds were investigated for their DNA damaging and anticancer effects: a pair of novel metal contain

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12

Sostelly, Alexandre. "Mechanistic model-based drug development in the management of anticancer drugs resistance." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10203.

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La résistance aux chimiothérapies anticancéreuses constitue un problème majeur dans la prise en charge du cancer. Les transporteurs d'efflux contribuent à ce phénomène de résistance en altérant l'accumulation intracellulaire des cytotoxiques. Dans le passé, l'inhibition du transporteur d'efflux P-gp n'a pas permis de surmonter ce phénomène notamment à cause du manque de méthodes adéquates pour identifier et quantifier la pharmacologie des inhibiteurs d'efflux. Récemment de nouveaux inhibiteurs de BCRP, l'un des derniers transporteurs d'efflux découverts, ont été synthétisés permettant de retes

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13

PELLIZZONI, ELENA. "Molecularly imprinted polymeric nanoparticles for the therapeutic drug monitoring of anticancer drugs." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2907991.

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La chemoterapia consiste nell’impiego di uno o di una combinazione di farmaci antitumorali per il trattamento del cancro. Tuttavia tali farmaci sono caratterizzati da una famacocinetica molto variabile e da una elevata tossicità che porta alla comparsa di molti effetti indesiderati nei pazienti, diminuendo l’efficienza della terapia. In questo contesto l’impiego del “Therapeutic Drug Monitoring” (TDM) risulta particolarmente importante in quanto permette per lo sviluppo di terapie personalizzate per i pazienti aumentando l’efficienza della terapia e la qualità della vita dei pazienti. Questo

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14

IACUZZI, VALENTINA. "Design of detection systems for the therapeutic drug monitoring of anticancer drugs." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2967986.

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Considerato che la maggior parte dei farmaci antitumorali risulta caratterizzata da un'alta variabilità interindividuale nelle concentrazioni plasmatiche, che si riflette sull'efficacia del trattamento, durante il progetto di dottorato qui descritto sono state sviluppate tecniche per il loro monitoraggio terapeutico (TDM). In primo luogo, è stato sviluppato, validato e cross-validato un metodo LC-MS/MS per la quantificazione di imatinib (IMA) e del suo metabolita attivo, norimatinib (norIMA), in pazienti affetti da tumore stromale gastrointestinale utilizzando la tecnica del dried blood spot (

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15

Marshall, Andrew James. "The development of PI3K inhibitors as anticancer drugs." Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/6440.

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Phosphatidylinositol 3-kinases (PI3Ks) are a lipid enzyme family that are vitally important regulators of intracellular signalling pathways which control cellular activities including cell survival, growth and proliferation. Deregulation of the PI3K signalling cascade has been observed in a broad range of human diseases including cancer, diabetes, thrombosis, immunity and inflammatory disorders. With the discovery of PI3K’s link to a variety of diseases, there has been a race to produce ATP competitive inhibitors as therapeutic agents against the Class I PI3K isozymes. Herein, compounds from t

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16

Sobhanian, Ali. "Synthetic and spectral studies of potential anticancer drugs." Thesis, University of Hertfordshire, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361263.

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17

Mitchinson, Andrew. "New synthetic routes to polyamines and their use in receptor studies." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481468.

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18

Lant, Neil Joseph. "The synthesis and evaluation of anti-melanoma drugs." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341748.

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19

Pireddu, Roberta. "New anticancer drugs : targeting tubulin and signal transduction pathways." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54618/.

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The main aim of the study described in this thesis is the development of new anticancer agents. The first chapter is a general introduction to cancer, and the development of chemotherapy anticancer agents during the course of the years. The following four chapters briefly introduce the biological targets in the authors study. Chapter Two describes a general introduction to tubulin and microtubules as anticancer targets. A discussion of those compounds most relevant to this thesis is provided. Chapter Three describes Signal Transducers and Activator of Transcription 3 (STAT3) proteins, their ro

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20

Harte, Robert J. A. "Pharmacokinetic evaluation of anticancer drugs using positron emitting nuclides." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337702.

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21

Jung, Yongwon 1977. "Cellular responses against DNA damaged by platinum anticancer drugs." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33746.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.<br>Vita.<br>Includes bibliographical references.<br>The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding of these processes is critical for developing more effective therapeutic approaches, which can increase the anti-cancer activity of the drugs while minimizing side effects and extending successful treatment to a wider range of human cancer

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22

Elsaid, Z. "Nanocarriers for the delivery of anticancer drugs and siRNA." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1467125/.

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Background and Purpose: Optimal benefit in the treatment of lung cancer is impeded due to systemic side effects, sub-therapeutic drug levels at the tumour site and the development of multidrug resistance. This thesis describes three related but distinct strategies aimed at enhancing drug treatment of lung cancer. Methods: The first approach entails design of micelles using three amphiphilic derivatives of chitosan (TPGS-chitosan, retinoic acid-chitosan-PEG and lipoic acid-chitosan-PEG (LACPEG)) for the pulmonary delivery of siRNA. Polymers where characterized using FT-IR and 1H NMR. Micelles p

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23

Bezoski, Brittany A. "Metal Binding Characteristics of Heterocyclic and Carbocyclic Anticancer Drugs." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1481287656969232.

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24

TOMMASINI, MARTINA. "Fluorescent Molecularly Imprinted Polymers as sensors for anticancer drugs." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2952847.

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Chemotherapy is a medical treatment mainly aimed at damaging solid and haematological tumors, by the administration of specific drugs able to target cancer cells. These drugs, however, often show many secondary effects and present variable inter-individual pharmacokinetics. Hence, the ideal optimization of the therapy would consist of continuously monitoring, in each patient, drug absorption in blood circulation, in order to adjust the daily dose regimen, decreasing therefore its side effects and improving the whole treatment. This methodology is known as Therapeutic Drug Monitoring (TDM) and

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25

Bowman, Karen Julia. "Evaluation of novel compounds to modulate the cytotoxicity of anticancer agents in mammalian cells." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246707.

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26

Gonzaliez, Laura Maritza Calderon. "Design, synthesis and evaluation of a scaffold and capping units based on the pyrrolo[2,1-c][1,4]benzodiazepines for combinatorial chemistry." Thesis, University of Portsmouth, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302662.

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27

Wattanatorn, Wiboon. "Pharmacokinetics of 5-fluorouracil in cancer patients." Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389482.

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28

Priston, Melanie Jane. "Studies on the pharmacokinetics and metabolism of mitozantrone." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303766.

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29

Swingler, Lisa G. "An investigation of the induction of vincristine and multidrug resistance in Chinese hamster ovary cells following exposure to hydroxyurea or adriamycin." Thesis, University of York, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306289.

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30

Pekcagliyan, Gonul. "Synthesis Of Topoisomerase Inhibitor Type Anticancer Drugs Linked Gold Nanoparticles." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609270/index.pdf.

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This study presents studies on camptothecin (CPT), a potent antitumor agent in order to improve its stability and solubility without reducing its activity. The work describes the modification of camptothecin at 20-OH position a new strategy to overcome the stability and solubility problems of the free drug. Camptothecin is conneted to linker that could be processed to a terminal thiol group and this thiol group was connected to gold surface, to obtain CPT-gold nanoparticles. In the first part of the study<br>undecenol was chosen as the starting material and reacted with azobisisobutylonitrile

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31

Karlsson, Henning. "New preclinical strategies for characterization and development of anticancer drugs." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330999.

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Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. The aims of this thesis were to improve preclinical models for cancer drug development, with focus on colorectal cancer (CRC)

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32

Liu, Bo. "Template-assembled synthetic G-quartets as targets for anticancer drugs." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42814.

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DNA is a classic target for small-molecule ligands. In order to reduce significant toxicities of anticancer drugs resulting from unspecific interactions with DNA duplexes, it aroused great interest to investigate the specific interactions of ligands with a secondary DNA structure, G-quadruplex, formed by a guanine-rich DNA sequence. Induction and stabilization of G-quadruplex structures by ligands have been shown to inhibit telomerase activities and regulate the transcription and expression levels of oncogenes in cancer cells; therefore, the design of synthetic G-quartets under physiological c

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33

Cadete, pires Ana cristina. "Hyaluronic acid nanocapsules for the intracellular delivery of anticancer drugs." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0071.

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Cette thèse de doctorat avait pour principal objectif le développement d’une méthode viable pour la formulation de nanocapsules d’acide hyaluronique (NCs HA) à des fins d’incorporation et de libération intracellulaire d’agents anticancéreux. La première étape de ce travail a visé le développement d’une méthode d’émulsion spontanée dans laquelle les NCs HA ont été formulées sans avoir recours à des solvants organiques, ni à un travail à haute température ou à un apport énergétique élevé, ce qui fournit des conditions optimales pour l’incorporation de biomolécules sensibles tout en diminuant l’i

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34

Figueiredo, João Daniel Amaral. "The effect of anticancer drugs prodiginines in PP1 in melanoma." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/6861.

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Mestrado em Biomedicina Molecular<br>Um dos principais mecanismos reguladores da função celular é a fosforilação de proteínas. É de focar que a fosforilação anormal de proteínas-chave pode estar associada a várias patologias, incluindo o cancro. Embora já existam muitos estudos sobre cinases no cancro, o conhecimento sobre as fosfatases que antagonizam a acção das cinases é muito menos. A PP1, uma das principais proteínas fosfatase de serina/treonina expressa em todas as células eucarióticas, está envolvida em vários processos celulares incluindo apoptosis e ciclo celular. Na realidade,

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35

Carmichael, Samantha Jane. "Optimisation of study design in the pharmacokinetics of anticancer drugs." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23290.

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"Optimal sampling strategies" are based upon the concept of 'information-rich' times within a concentration-time profile. In this thesis, the selection of optimal sampling times was based on sensitivity analysis and applied to the one and two-compartment PK models. Simulation studies were used to show that parameter estimates obtained using an optimal design method with a reduced number of samples were as good as, if not better than, those obtained from PK studies in which the sampling times were selected empirically. In addition, the effect of adding sampling windows around the "optimal" time

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36

CONSONNI, ELISA. "Anticancer drugs mechanism of action investigated by advanced biomolecular tools." Doctoral thesis, Università degli Studi di Milano, 2005. http://hdl.handle.net/2434/61944.

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Pixantrone (BBR2778), a DNA intercalating agent topoisomerase II inhibitor, belongs to the aza-anthracenedione chemical class and is currently under clinical investigation in non-dgkn iymphomas (NHLs)

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37

Ferrari, E. "PHARMACOGENOMIC APPROACHES TO IDENTIFY AND CHARACTERIZE TARGETS OF ANTICANCER DRUGS." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155506.

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Encouraging clinical studies are recently showing how a number of anticancer compounds work through a synthetic lethal mechanism by targeting pathways that are specifically essential for the viability of cancer cells but not of normal cells. We applied the concept of synthetic lethality by performing yeast high-throughput screens to define the chemical-genetic profile of three chemotherapeutic drugs: cisplatin, ecteinascidin, 5-fluorouracil. By means of the DDR-library, a collection of mutants defective in the DNA damage response, we identified the DNA repair pathways required to survive to

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38

Shahbakhti, Hassan. "Structure/activity relationships of antitumour diazridinylquinones." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308289.

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39

Mi, Zihou. "Chemical Dynamics of Camptothecin Anticancer Drugs in Human Blood: Impact on Drug Stability and Activity /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487930304688618.

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40

Wang, Han. "Developing Novel Drug Delivery Systems For Platinum-based Anticancer Drugs Using Coordination-driven Self-assembly." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1595260147978142.

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41

LA, FRANCA Mery. "Design, synthesis and biological evaluation of new anticancer drugs: FGFR inhibitors." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/475964.

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Fibroblast growth factor receptors (FGFRs) constitute a family of tyrosine kinases receptors (RTKs) that exert pivotal physiological functions in human embryonic and adult tissues. Hyperactivated FGFR signaling drives tumorigenesis in multiple cancer types, including lung and brain cancers. Great effort has been laid on the development of new compounds that specifically target the FGFR axis. However, cancer cell- based and microenvironmental resistance mechanisms against FGFR inhibitors often arise and are currently poorly understood. Furthermore, FGFR-targeted therapy often presents differen

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42

Celik, Haydar. "Enzyme-catalyzed Reductive Activation Of Anticancer Drugs Idarubicin And Mitomycin C." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609247/index.pdf.

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Idarubicin (IDA) and mitomycin C (MC) are clinically effective quinone-containing anticancer agents used in the treatment of several human cancers. Quinone-containing anticancer drugs have the potential to undergo bioreduction by oxidoreductases to reactive species, and thereby exert their cytotoxic effects. In the present study, we investigated, for the first time, the potential of IDA, in comparison to MC, to undergo reductive activation by NADPH-cytochrome P450 reductase (P450R), NADH-cytochrome b5 reductase (b5R) and P450R-cytochrome P4502B4 (CYP2B4) system by performing both in vitro plas

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43

Mellish, Kirstie Joanne. "The cellular and molecular pharmacology of novel platinum-based anticancer drugs." Thesis, Institute of Cancer Research (University Of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242998.

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44

Ward, T. H. "Bioreductive anticancer drugs : a comet study on mechanisms and DNA damage." Thesis, University of Salford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245022.

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45

Walton, Michael Ian. "The effects of hyperthermia on the pharmacokinetics of selected anticancer drugs." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254220.

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46

Alzahrani, Mona Moshref. "Development of New Vanadium and Iron complexes for potential anticancer drugs." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/dissertations/2877.

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In recent years, metals based antitumor complexes have played an important role in chemotherapy. In this study, two new metal complexes - dioxovandium LVO2 and dichloroiron LFeCl2-have been synthesized. The dioxovanadium complex LVO2 is formed from the reaction between the ligand HL and VO(acac)2 in 1:1 molar ratio, while the dichloroiron complex was prepared from the reaction between ligand HL with FeCl2 in 1:2 molar ratio. Both new complexes have been characterized by FT -IR and UV -Vis. The IR spectrum revealed the absorption band changes between the complexes and their ligand, and UV -Vis

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47

Yang, Jianning. "Mechanism-Based Computational Models to Study Pharmacological Actions of Anticancer Drugs." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1249622434.

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48

LA, FRANCA Mery. "Design, synthesis and biological evaluation of new anticancer drugs: FGFR inhibitors." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/491643.

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Fibroblast growth factor receptors (FGFRs) constitute a family of tyrosine kinases receptors (RTKs) that exert pivotal physiological functions in human embryonic and adult tissues. Hyperactivated FGFR signaling drives tumorigenesis in multiple cancer types, including lung and brain cancers. Great effort has been laid on the development of new compounds that specifically target the FGFR axis. However, cancer cell- based and microenvironmental resistance mechanisms against FGFR inhibitors often arise and are currently poorly understood. Furthermore, FGFR-targeted therapy often presents differe

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49

Punchihewa, Chandanamalie. "DNA and DNA-Interacting Proteins as Anticancer Drug Targets." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194379.

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DNA is both the oldest and newest of targets for cancer therapy. While it is already being targeted by many anticancer drugs in the clinic, the development of sequence-specific DNA binders has brought it back to the limelight as a valuable anticancer drug target.My studies on DNA interacting agents was initiated with the DNA intercalator campotothecin, and also included topoisomerase I enzyme. I have evaluated the structure of topoisomerase I C-terminal domain that consists of the active site tyrosine. My data indicate that this domain exists in a molten globule conformation with a fluctuating

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50

Heyenga, Gerard. "Tissue culture of Podophyllum hexandrum and production of anticancer ligands." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235985.

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