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Journal articles on the topic 'Anticancer MCF-7'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Devi, Senthil, Velliyagounder Venkateswaran, and Kanakaraj Lakshmi. "Cytotoxic evaluation of curcumin and quercetin in MCF-7 cell lines." World Journal of Biology Pharmacy and Health Sciences 17, no. 2 (2024): 149–54. https://doi.org/10.5281/zenodo.11283598.

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Cytotoxic evaluation of Curcumin and Quercetin in MCF-7 cell lines was performed to assess their potential anticancer activity. MCF-7 is a widely used breast cancer cell line, and evaluating the cytotoxic effects of the compounds on these cells can provide valuable information about their potential as an anticancer agent. Curcumin, a naturally occurring compound found in turmeric, has been extensively studied for its potential anticancer properties, including its effects on MCF-7 cell lines. MCF-7 cells are commonly used as a model for studying breast cancer. Quercetin, a flavonoid found in va

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2

Devi Senthil, Venkateswaran Velliyagounder, and Lakshmi Kanakaraj. "Cytotoxic evaluation of curcumin and quercetin in MCF-7 cell lines." World Journal of Biology Pharmacy and Health Sciences 17, no. 2 (2024): 149–54. http://dx.doi.org/10.30574/wjbphs.2024.17.2.0048.

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Cytotoxic evaluation of Curcumin and Quercetin in MCF-7 cell lines was performed to assess their potential anticancer activity. MCF-7 is a widely used breast cancer cell line, and evaluating the cytotoxic effects of the compounds on these cells can provide valuable information about their potential as an anticancer agent. Curcumin, a naturally occurring compound found in turmeric, has been extensively studied for its potential anticancer properties, including its effects on MCF-7 cell lines. MCF-7 cells are commonly used as a model for studying breast cancer. Quercetin, a flavonoid found in va

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3

Wang, Li-Ping, Zhi Xu, Gui-Ying Deng, and Sha-Li Xu. "Antiproliferative Activity of 8-methoxy Ciprofloxacin-Hydrozone/Acylhydrazone Scaffolds." Current Topics in Medicinal Chemistry 20, no. 21 (2020): 1911–15. http://dx.doi.org/10.2174/1568026620666200603105644.

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Aims: A series of 8-methoxy ciprofloxacin- hydrazone/acylhydrazone hybrids were evaluated for their activity against a panel of cancer cell lines including HepG2 liver cancer cells, MCF-7, doxorubicin- resistant MCF-7 (MCF-7/DOX) breast cancer cells, DU-145 and multidrug-resistant DU145 (MDR DU-145) prostate cancer cells to seek for novel anticancer agents. Background: Ciprofloxacin with excellent pharmacokinetic properties as well as few side effects, is one of the most common used antibacterial agents. Notably, Ciprofloxacin could induce cancer cells apoptosis, and cell cycle arrest at the S

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4

Salman, Husam Hamza, Munther Abduljaleel Mohammed Ali, and Eman Tariq Ali. "Synthesis and screening of anticancer potentials of some new terephthaldehyde-derived nitrone compounds." Tropical Journal of Pharmaceutical Research 19, no. 2 (2020): 341–49. http://dx.doi.org/10.4314/tjpr.v19i2.17.

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Purpose: To synthesize and screen some new nitrone compounds derived from terephthaldehyde for their anticancer potential. Methods: Six new compounds (H, p-Me,p-Br, p-Cl, o-Cl and m-Me) were synthesized via a condensation reaction between terephthaldehyde and a variety of aryl hydroxylamine compounds derived from nitrobenzene and its derivatives. The chemical structures of these compounds were identified using elemental CHN analysis and were elucidated using Fourier Transform infra-red (FT-IR), 1H-nuclear magnetic resonance (1H NMR), mass spectrometry (MS), and elemental analysis. The an

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5

Achakzai, Jahangir Khan, Muhammad Anwar Panezai, Muhammad Ayub Kakar, et al. "In Vitro Anticancer MCF-7, Anti-Inflammatory, and Brine Shrimp Lethality Assay (BSLA) and GC-MS Analysis of Whole Plant Butanol Fraction of Rheum ribes (WBFRR)." BioMed Research International 2019 (June 23, 2019): 1–8. http://dx.doi.org/10.1155/2019/3264846.

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In this study, GC-MS analysis has shown that whole plant butanol fraction of rheum ribes (WBFRR) comprises of 21 compounds which exhibited anticancer (MCF-7) activity having IC50 value of 36.01± 0.26. MTT assay (MCF-7), Oxidative Burst assay using chemiluminescence technique, and B-Hatching techniques were the methods used for anticancer MCF-7, anti-inflammatory, and Brine Shrimp Lethality Assay (BSLA). GC-MS was used for structural elucidation. Whole plant methanol extract of rheum ribes (WMERR), whole plant n-hexane fraction of rheum ribes (WHFRR), and whole plant aqueous fraction of rheum r

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6

Misgiati, Misgiati. "POTENSI EKSTRAK N-HEKSAN, DIKLOROMETANA, ETIL ASETAT, DAN ETANOL 70% JAMUR DEWA (Agaricus blazei Murill) TERHADAP SEL MCF-7." Jurnal Riset Kefarmasian Indonesia 4, no. 1 (2022): 11–23. http://dx.doi.org/10.33759/jrki.v4i1.231.

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God mushroom is a functional food. It has pharmacological activity. This content has activity as an anticancer. The purpose of this study was to conduct a preliminary test to obtain an active ingredient capable of having anticancer activity on MCF-7 cells. The stages of the research are stratified extraction with several solvents. Extraction using maceration. The resulting extract was identified and tested for the anticancer activity of MCF-7 cells. The test uses the TLC method. The stationary phase with silica GF254, the mobile phase is n-hexane: ethyl acetate. Anticancer activity test using

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7

Li, Daichun, Xiaojian Liao, Shenghui Zhong, Bingxin Zhao, and Shihai Xu. "Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents." Marine Drugs 20, no. 3 (2022): 158. http://dx.doi.org/10.3390/md20030158.

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In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC50 values of 1.65 ± 0.30 (MCF-7), 2.91 ± 0.17 (HepG2), 4.59 ± 0.27 (MD-MBA-231), 5.69 ± 0.37 (Hela), and 5.96 ± 0.41 (A549) μg/mL, respectively. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry expe

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8

H Al-Ghamdi, Fuad. "Effect of anticancer electromagnetic spectrums on the cancer cell line growths." Journal of Medical Pharmaceutical and Allied Sciences 13, no. 3 (2024): 6603–7. http://dx.doi.org/10.55522/jmpas.v13i3.6511.

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Electromagnetic frequencies (EMF) that are generated from different electronic devices can interact with biological systems including humans. Several theories described the effects of EMF on the growth of in vitro cancer cell lines and biological systems, which revealed that EMF could inhibit cancer cell growth or decrease viability depending on the field strength and frequency. Accordingly, in this study, we are targeting to assess the effect of the anticancer-extracted electromagnetic spectrums on the growth of two types of cell lines which are the breast cancer cell line MCF-7 and human emb

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9

Yang, Xiaoting, Zhan Jin, Gao Chen, and Gaobo Hu. "Chloroquine inhibits salinomycin-induced autophagy for collaborative anticancer effect in breast cancer." BioImpacts 15 (May 25, 2025): 30821. https://doi.org/10.34172/bi.30821.

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Introduction: Breast cancer (BC) presents significant morbidity and mortality challenges. Autophagy plays a contradictory role in BC. The chemotherapeutic agent salinomycin exhibits anticancer effects, but its effectiveness is limited by over-activation of autophagy. This study aimed to investigate the effects and mechanisms of salinomycin and its combination with chloroquine in BC. Methods: The MCF-7 and MCF-7 tumor spheroids (MCF-7-TS) BC models were treated separately with salinomycin and autophagy inducer/inhibitor (rapamycin/chloroquine). Cell proliferation, apoptosis, and cell cycle prog

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Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity." Crystals 11, no. 5 (2021): 571. http://dx.doi.org/10.3390/cryst11050571.

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This research aimed to produce new 1-[(aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic acid derivatives and check their anticancer effect against the breast cancer MCF-7 cell line. The 2-oxo-1,2-dihydroquinoline-3-carboxylic acid (4) compound was obtained by hydrolyzing ethyl 2-oxo-1,2-dihydroquinoline-3-carboxylate (2) with thiourea and anhydrous potassium carbonate ethanol, which was then treated with ethyl 3-substituted 2-cyanoacrylates (6) in the presence of triethylamine in diethyl formamide to give 1-[2-(ethoxy)carbonyl-2-cyano-1-arylvinyl]-2-oxo

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11

Bo Wang, Bo Wang, Zhi qiang Cai Zhi qiang Cai, Xiao yu Shi Xiao yu Shi, Xiang Li Xiang Li, Shuai Li Shuai Li, and and Ji xin Li and Ji xin Li. "Synthesis, Crystal Structure and Anticancer Activity of Substituted Quinazoline Derivatives." Journal of the chemical society of pakistan 43, no. 4 (2021): 466. http://dx.doi.org/10.52568/000583/jcsp/43.04.2021.

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News series of substituted quinazoline derivatives has been synthesized from 3,4-dihydro-7-methoxy-4-oxoquinazoline-6-yl acetate (1) by five-step procedures including chlorination, amination, hydrolysis and etherification. The structures of target compounds were confirmed by IR, 1H-NMR, element analysis and single-crystal X-ray diffraction. The results showed that the compound 8c exhibited remarkable inhibitory activity against MCF-7 cell lines with inhibition rate value of 38.45 %, which was comparable to that of the positive control Gefitinib (inhibition rate = 13.25 % for MCF-7). The initia

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Bo Wang, Bo Wang, Zhi qiang Cai Zhi qiang Cai, Xiao yu Shi Xiao yu Shi, Xiang Li Xiang Li, Shuai Li Shuai Li, and and Ji xin Li and Ji xin Li. "Synthesis, Crystal Structure and Anticancer Activity of Substituted Quinazoline Derivatives." Journal of the chemical society of pakistan 43, no. 4 (2021): 466. http://dx.doi.org/10.52568/000583.

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News series of substituted quinazoline derivatives has been synthesized from 3,4-dihydro-7-methoxy-4-oxoquinazoline-6-yl acetate (1) by five-step procedures including chlorination, amination, hydrolysis and etherification. The structures of target compounds were confirmed by IR, 1H-NMR, element analysis and single-crystal X-ray diffraction. The results showed that the compound 8c exhibited remarkable inhibitory activity against MCF-7 cell lines with inhibition rate value of 38.45 %, which was comparable to that of the positive control Gefitinib (inhibition rate = 13.25 % for MCF-7). The initia

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13

Zamulaeva, Irina, Yevgeniy Severin, Irina Kondrasheva, et al. "ANTICANCER ACTIVITY OF DOXORUBICIN CONJUGATES WITH DENDRITIC POLYMERS OF SECOND GENERATION AND VECTOR PROTEIN IN MODEL SYSTEMS IN VITRO AND IN VIVO." Problems in oncology 64, no. 1 (2018): 131–37. http://dx.doi.org/10.37469/0507-3758-2018-64-1-131-137.

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Anticancer activity of doxorubicin (Dox), its conjugates with the second generation dendritic polymer (G2-Dox) and vector protein (recombinant third domain of alpha-fetoprotein - 3D-G2-Dox were studied in vitro and in vivo within the framework of the development of selective transport system of anticancer drugs to the target cells. The objects of the study were MCF-7 and MCF-7/MDR1 breast cancer cells, differing in chemosensitivity as well as mouse melanoma line B16. Anticancer activity of G2-Dox and 3D-G2-Dox was demonstrated in vivo (for B16 melanoma) and in vitro (for chemoresistant MCF-7/M

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14

Oliveira, Thaís A. S., Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, and Antônio E. M. Crotti. "Anticancer Activity of 4-Aryl-1,4-Dihydropyridines." Future Pharmacology 4, no. 3 (2024): 564–73. http://dx.doi.org/10.3390/futurepharmacol4030031.

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We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human glioblastoma), HeLa 229 (human cervical adenocarcinoma), and MCF-7 (human breast carcinoma). None of the 1,4-DHPs were cytotoxic to U-251MG cells. Most of the 1,4-DHPs did not affect HeLa 229 or MCF-7 cell viability. On the other hand, symmetric 1,4-DHPs 18 (diethyl 4-(4-benzyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate), 19 (die

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15

Kumari, Sumita, Amit Sharma, Navgeet Kaur, and Sonia Yadav. "Novel Coumarin Chalcone Derivatives: Synthesis and Anticancer Evaluation." International Research Journal of Multidisciplinary Scope 06, no. 02 (2025): 960–72. https://doi.org/10.47857/irjms.2025.v06i02.03636.

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Breast cancer is the most frequently diagnosed disease which affects women ’s worldwide. Aggressiveness of cancer cells has thwarted several scientific approaches, preventing their invasion and spread to nearby tissues despite scientists’ unrelenting attempts. In this study, a series of coumarin chalcone hybrids were designed and synthesised by Vilsmeier-Haack, nucleophilic aromatic substitution and Claisen condensation reaction. Characterization of derivatives done by spectral studies such as IR, NMR and Mass spectrometry. The purpose of this work was assessing the cytotoxic effects of recent

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16

Drogosz-Stachowicz, Joanna, Katarzyna Gach-Janczak, Marek Mirowski, Jacek Pietrzak, Tomasz Janecki, and Anna Janecka. "Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4,9-dione." Molecules 28, no. 7 (2023): 3128. http://dx.doi.org/10.3390/molecules28073128.

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Herein, the antitumor activity of a novel synthetic analog with 5,8-quinolinedione scaffold, diethyl (2-(2-chlorophenyl)-4,9-dioxo-4,9-dihydrofuro [3,2-g]quinolin-3-yl)phosphonate (AJ-418) was investigated on two breast cancer cell lines. This analog was selected from a small library of synthetic quinolinediones on the basis of its strong antiproliferative activity against MCF-7 and MDA-MB-231 cells and 4-5-fold lower cytotoxicity towards healthy MCF-10A cells. The morphology of MCF-7 and MDA-MB-231 cancer cells treated with AJ-418 changed drastically, while non-tumorigenic MCF-10A cells remai

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Altıntop, Mehlika D., Belgin Sever, Ahmet Özdemir, et al. "Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents." Anti-Cancer Agents in Medicinal Chemistry 18, no. 11 (2019): 1606–16. http://dx.doi.org/10.2174/1871520618666180509111351.

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Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-[(5-(arylamino)-1,3,4-thiadiazol-2-yl)thio]acetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using MTT assay. <p> Results: Phenyl-substituted compounds (8-14) were found to be more effective than naphthyl-substituted compounds (1-7) on cancer cells. Compounds 8, 9, 10

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18

Pansuriya, V. B., P. V. Dholaria, S. L. Rathod, et al. "In vitro Cytotoxic Activity against MCF-7 Breast Cancer Cells Line: Pregabalin and Chiral Amino Acid-based Peptides." Asian Journal of Chemistry 34, no. 4 (2022): 871–78. http://dx.doi.org/10.14233/ajchem.2022.23566.

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Because of the medicinal application of peptides in the current drug discovery process, we report the synthesis and in vitro anticancer activity of various pregabalin containing peptides using chiral amino acids. The structures of newly synthesized compounds were assigned based on IR, 1H NMR, 13C NMR and mass spectral analysis. Synthesized peptides were screened for their anticancer activity on human breast cancer MCF-7 cells line by MMT assays method. Evaluation of anticancer activity shown that compound 13a (16.65% cell proliferation) was found to be most active against selected MCF-7 cell l

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Baskaran Subramani and Baradwaj R.G. "Antibacterial, anti-oxidant and in vitro anticancer analysis of Zingiber officinale (L.) Rosc." JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH 1, no. 6 (2021): 33–49. http://dx.doi.org/10.46947/joaasr16201635.

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Ginger is considered as an important spice with many clinical potential activities. The present study was undertaken to determine antimicrobial, antioxidant and in vitro anticancer activities of rhizome extract of Zingiber officinale. Antimicrobial activity was tested against Staphylococcus aureus, Bacillus subtilis, Vibrio cholera, Vibrio parahaemolyticus, Pseudomonas aeruginosa, Entero toxigenic Excherichia coli (ETEC) and Salmonella typhi by disc diffusion assay. Antioxidant activity was determined by DPPH free radical scavenging assay and ABTS free radical scavenging assay. The ethanolic e

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20

Mubeen, Muhammad, Suvarna Ganesh Kini, Avinash Kumar, and Karkala Sreedhara Ranganath Pai. "Design, Synthesis, Biological Evaluation and In Silico Studies of Few Novel 2-Substituted Benzothiazole Derivatives as Potential EGFR Inhibitors." Letters in Drug Design & Discovery 16, no. 8 (2019): 961–71. http://dx.doi.org/10.2174/1570180816666181108112228.

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Background: There is a great unmet medical need for new anticancer small molecule therapeutics. Exhaustive literature review suggests that benzothiazole derivatives have good potential to exhibit anticancer activity. Compounds that inhibit the kinase activity of EGFR are of potential interest as new antitumor agent. Objective: To design, synthesize and carry out in silico along with biological evaluation of 2- substituted benzothiazole compounds with EGFR inhibitory activity. Methods: Benzothiazole derivatives designed from molecular docking method for potential EGFR tyrosine kinase inhibition

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Sukohar, Asep, Dwi Aulia Ramdini, Citra Yuliyanda Pardilawati, and Suharyani Suharyani. "Investigation of Antioxidant and Anticancer Activity againts MCF-7 and HeLa Cancer Cells of Melinjo (Gnetum gnemon L.)." Biomedical and Pharmacology Journal 16, no. 4 (2023): 2177–85. http://dx.doi.org/10.13005/bpj/2794.

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Background: One of the major causes of death in the world is cancer. The cancer frequently affects in women especially breast cancer and cervical cancer. Many anticancer drugs have been developing throughout time due to the side effect of cancer treatments. Current study, plants have been extensively explore for their bioactive compound that is effective as anticancer drug candidates. Gnetum gnemon L. plant contains a bioactive compound that is beneficial for health and can be developed as an anticancer agent. Objective: The aim of this study was to investigate the potential of Gnetum gnemon L

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Daud, Akmal Arif. "Combination treatment of Clinacanthus nutans extract with cisplatin against breast cancer cell line, MCF-7." International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science 7, no. 1 (2024): 90–98. http://dx.doi.org/10.24191/ijpnacs.v7i1.08.

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Chemotherapy is one of the treatments for cancer and among the important agent is cisplatin. However, owing to the adverse effects associated with modern medicine, patients often explore traditional herbal remedies for cancer management. Clinacanthus nutans is widely believed to possess healing properties for various ailments, including cancer. The cultural and traditional background of this plant increases its acceptance among patients seeking alternative or complementary treatments. There exists a growing concern regarding the potential impact of C. nutans on the efficacy of cisplatin in tre

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BOONTHA, Supavadee, Benjaporn BURANRAT, Kamchai SAEPANG, and Tasana PITAKSUTEEPONG. "Comparison of the potential of extracts from the flower, fruit pulp, and seed of Cassia fistula L. on MCF-7 breast cancer cell growth and cell migration." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 51, no. 3 (2023): 13086. http://dx.doi.org/10.15835/nbha51313086.

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This study aimed to determine the anticancer effects of extracts prepared from various parts of Cassia fistula L. (CF), i.e., flower extract (FE), fruit pulp extract (FPE) and seed extract (SE), on MCF-7 breast cancer cells. The anticancer effects of the extracts were assessed for cell toxicity, cell proliferation, cell migration, cell apoptosis, and production of reactive oxygen species (ROS). Effective cancer treatments have focused on inhibiting epidermal growth factor receptor (EGFR) signalling. Thus, the expression of EGFR protein after extract-treated cells was also determined. Following

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Harfita, Nur Laily, Adlis Santoni, and Suryati Suryati. "Beta-sitosterol glycoside from Paraboea leuserensis and Cytotoxicity Test against MCF-7 Human Breast Cancer Cells." Riset Informasi Kesehatan 12, no. 2 (2023): 272. http://dx.doi.org/10.30644/rik.v12i2.826.

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Background: Paraboea leuserensis, a plant endemic to the Leuser Mountain in the provinces of Aceh and North Sumatra, has been traditionally used for medicinal purposes by chewing or boiling, addressing conditions such as stomachaches and providing stamina enhancement. This study aimed to isolate secondary metabolite compounds from Paraboea leuserensis and conduct in vitro anticancer tests. Method: The ethyl acetate extract was isolated through column chromatography, yielding beta-sitosterol glycoside, and was tested for bioactivity against human breast cancer cells MCF-7 using the MTT me

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Kotthireddy, Thirumal Reddy, Sreenivasulu Reddymasu, and Ramesh Raju Rudraraju. "Synthesis and biological evaluation of 1,2,4-oxadiazole linked imidazopyrazine derivatives as anticancer agents." Journal of Indian Chemical Society Vol. 96, Aug 2019 (2019): 1085–90. https://doi.org/10.5281/zenodo.5638401.

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Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, Andhra Pradesh, India Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India <em>E-mail:</em> reddymasu.msc@gmail.com <em>Manuscript received online 21 May 2019, revised 24 June 2019, accepted 25 June 2019</em> A series of new 1,2,4-oxadiazole linked imidazopyrazines (10a-j) were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines, such as MCF-7 (breast), A-549 (lung), and

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Marvaniya, Vanita, Hirak V. Joshi, Ujashkumar A. Shah, and Jayvadan K. Patel. "Synthesis, Anticancer Evaluation and Molecular Docking Studies of Isonicotinamide and Diaryl Urea Hybrid Motifs." Asian Journal of Organic & Medicinal Chemistry 7, no. 2 (2022): 179–86. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p382.

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In search of new anticancer agents with improved efficacy, we designed and synthesized novel hybrid series of isonicotinamide and diaryl urea motifs (R1-R9). Design of series compounds carried out using docking study by Autodock vina tool. Binding energy (more than -9.7 kcal/mol) calculated using Autodock vina against Raf kinase (PDB: 4DBN). All the synthesized compounds were evaluated for them in vitro anticancer activity against MCF-7 cell line. The anticancer activities of the synthesized compounds were also carried. Some of the compounds (R1, R8, R9) showed better activities towards MCF-7

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Dong, Jinyun, Guang Huang, Qijing Zhang, et al. "Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents." MedChemComm 10, no. 9 (2019): 1606–14. http://dx.doi.org/10.1039/c9md00258h.

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A series of benzochalcone derivatives have been synthesized and evaluated for CYP1 inhibitory activity and cytotoxic properties against wild type cell lines (MCF-7 and MDA-MB-231) and drug resistant cell lines (LCC6/P-gp and MCF-7/1B1).

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Dubey, Richa, and Kuldeep Singh Patel. "Design, Molecular Docking, Synthesis, Anticancer activity of Thiazolidinedione derivatives." International Journal of Research in Pharmaceutical Sciences 15, no. 2 (2024): 10–18. http://dx.doi.org/10.26452/ijrps.v15i2.4670.

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Newly designed thiazolidine-2, four-diones RD1-RD15 were synthesized, and their anticancer activities were screened against MCF-7 cancer cells. They exhibited significant activities against MCF-7 cancer cell lines. Compounds RD3 and RD9 were identified as highly potent derivatives against MCF-7 (IC50 = 6.58 and 9.15 µM, respectively). The highly effective derivatives RD1, RD9, RD6, and RD15 were also tested against VERO normal cell lines. All derivatives were evaluated for their androgen inhibitory activities and showed varying degrees of potency, with IC50 values ranging from 0.07 to 0.83 µM.

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Pedron, Cibele Nicolaski, Gislaine Patricia Andrade, Roseli Hiromi Sato, et al. "Anticancer activity of VmCT1 analogs against MCF-7 cells." Chemical Biology & Drug Design 91, no. 2 (2017): 588–96. http://dx.doi.org/10.1111/cbdd.13123.

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Sirait, Putriana Sari, Iriani Setyaningsih, and Kustiariyah Tarman. "Anticancer Activity of Spirulina Cultivated in Walne and Organic Media." Jurnal Pengolahan Hasil Perikanan Indonesia 22, no. 1 (2019): 50. http://dx.doi.org/10.17844/jphpi.v22i1.25876.

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Spirulina is Cyanobacteria containing active components which is potentially showing anticancer activity. The purposes of this study were to determine anticancer activity and selectivity of crude extracts<br />of Spirulina cultured using Walne and organic media, and to detect the apoptosis. The stages of this study included cultivation and harvesting of Spirulina, active components extraction, anticancer test and apoptosis<br />detection. Anticancer activity was determined using MTT assay. The crude extracts of Spirulina from Walne and organic cultures contained active components o

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Wu, Tong, Ting Li, Ya-Nan Kang, et al. "Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents." Molecules 23, no. 9 (2018): 2146. http://dx.doi.org/10.3390/molecules23092146.

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A series of novel alkyl amine-substituted icariside II (ICA II) derivatives were synthesized by Mannich reactions at the 6-C position (compounds 4a–d) and changing the carbon chain length at the 7-OH position (compounds 7a–h), and their in vitro antitumor activity towards human breast cancer lines (MCF-7 and MDA-MB-231) and human hepatoma cell lines (HepG2 and HCCLM3-LUC) were evaluated by the MTT assay. Compared with ICA II, most of the twelve derivatives showed good micromole level activity and a preliminary structure-activity relationship (SAR) for the anticancer activity was obtained. Comp

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Wulandari, Asri Peni, R. R. Indry Noviarin Examinati, Madihah ., Desi Harneti Putri Huspa, Poniah Andayaningsih, and Poniah Andayaningsih. "CYTOTOXICITY OF METABOLITES PRODUCED BY ENDOPHYTIC FUNGUS CLADOSPORIUM SP. ISOLATED FROM MARINE MACROALGAE ON INVITRO MCF7, HELA, AND DU-145 CELL LINES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 8 (2018): 72. http://dx.doi.org/10.22159/ijpps.2018v10i8.25181.

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Objective: To investigate the in vitro cytotoxicity effect of the crude ethyl acetate extract of Cladosporium sp. on MCF-7, HeLa, and DU-145 cell lines.Methods: In vitro cytotoxicity was evaluated by tetrazolium reduction assay. The percentage of cell inhibition was analyzed using probit analysis to obtain 50% inhibitory concentration (IC50). Morphological alteration of the cell lines after exposure with extract was observed under an inverted microscope.Results: The ethyl acetate extract of the metabolite performed an anticancer activity for cancer cell line MCF-7, HeLa, and DU-145 with IC50 r

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Dervişoğlu, Gökhan. "Anticancer effects of sodium selenate in human neuroblastoma, breast cancer, and melanoma cells." International Journal of Secondary Metabolite 12, no. 1 (2025): 225–34. https://doi.org/10.21448/ijsm.1553575.

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Sodium selenate (Na2SeO4) is one of the oxidized inorganic forms of selenium. Effects on cytotoxicity, total antioxidant level, total oxidant level, oxidative stress, and genotoxicity status and its anticancer effect on SH-SY5Y human neuroblastoma, MCF-7 human breast cancer, and 451Lu human melanoma cells were investigated in this study. Sodium selenate exhibited a highly cytotoxic effect at all concentrations (0.078125 - 10 mg/mL) against SH-SY5Y, MCF-7, and 451Lu cancer cell lines. In addition, sodium selenate reduced the total antioxidant levels, increased the total oxidant levels (except f

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Ajumeera, Rajanna, Ganapathi Thipparapu, Shireesha Boyapati, Bharath Singh Padya, and Vijayalaxmi Venkatesan. "Synthesis and Evaluation of Triazolyl Dihydropyrimidines as Potential Anticancer Agents." International Journal of Chemistry 10, no. 4 (2018): 18. http://dx.doi.org/10.5539/ijc.v10n4p18.

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Novel N &ndash; triazolyl 3(a-f) and O-triazolyl (4a-f) derivatives of 4, 6-diaryl-1, 4-dihydropyrimidines were synthesized through mannich reaction. All compounds were characterized by physical and spectral data. These compounds were screened for in vitro efficiency in human breast cancer cell (MCF-7&amp;MDA-MB-231) lines and found to have very good anti-proliferative activity.&nbsp; Among all compounds of 4b, 3e, 4e endowed with lesser respective IC50 values of 31.94, 55.73, 55.03 &micro;M in MCF-7 cells and 41.50, 35.28, 32.06 &micro;M in MDA-MB 231 cells by MTT assay. I

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Lubna, Abdulazeem, Abdalkareem Jasim Saade, and Ayad Abdulrazzaq Sumaya. "Biosynthesis, Characterization, Anticancer activity and Drug delivery of Gold Nanoparticles synthesised from local isolate of Proteus mirabilis." Research Journal of Biotechnology 17, no. 7 (2022): 41–47. http://dx.doi.org/10.25303/1707rjbt41047.

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Intracellular metal nanoparticles are produced by a variety of bacteria. As aqueous gold reacts with the Proteus mirabilis, it grows resulting in the formation of gold nanoparticles. The use of microorganisms in nanoparticle synthesis is gaining traction as an environmentally sustainable and exciting gold recovery process. This study consist of biological synthesis of gold nanoparticles utilizing the culture supernatant of local bacteria. Proteus mirabilis isolates when treated with HAuCl₄ solution in 10⁻³ Mm, then AuNPs were characterized and examined for anticancer ability using MTT assay ag

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Janowska, Sara, Dmytro Khylyuk, Agnieszka Gornowicz, et al. "Synthesis and Anticancer Activity of 1,3,4-thiadiazoles with 3-Methoxyphenyl Substituent." Molecules 27, no. 20 (2022): 6977. http://dx.doi.org/10.3390/molecules27206977.

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Based on the results of previous work, we designed and synthesized 1,3,4-thiadiazole derivatives. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and a normal cell line (fibroblasts). The results showed that all compounds displayed weak anticancer activity towards two breast cancer lines: an estrogen-dependent cell line (MCF-7) and an estrogen-independent cell line (MDA-MB-231). The compound most active towards MCF-7 breast cancer cells was SCT-4, which decreased DNA biosynthesis to 70% ± 3 at 100 µM. The

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Al-Oqail, Mai M., and Nida N. Farshori. "Antioxidant and Anticancer Efficacies of Anethum graveolens against Human Breast Carcinoma Cells through Oxidative Stress and Caspase Dependency." BioMed Research International 2021 (May 4, 2021): 1–12. http://dx.doi.org/10.1155/2021/5535570.

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Anethum graveolens, belonging to the family Apiaceae, has been extensively used for medicinal and therapeutic purposes since long. Plants encompass rich number of effective constituents with less toxicity. Thus, nowadays, the attempts are being made to search plant constituents that can prevent and reverse the chronic diseases, such as cancer. In this study, an in vitro antioxidant and anticancer efficacies of Anethum graveolens (AG-ME) were studied on human breast (MCF-7), lung (A-549), and cervical (HeLa) carcinoma cell lines. The antioxidant efficacies of AG-ME were evaluated by total antio

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Al-Bayati, Ammar I., Ammar A. Razzak Mahmood, Zainab A. Al-Mazaydeh, et al. "Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives." Pharmacia 68, no. 2 (2021): 449–61. http://dx.doi.org/10.3897/pharmacia.68.e66788.

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Novel compounds (6–10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, 1HNMR and CHNS. Their cytotoxic effect was evaluated by MTT assay against two cancer cell lines and two normal cell types. Compound 7 exhibited anticancer activity against MCF-7 breast cancer cell line (GI50 = 63.9 µg/ml, 148 µM), without any effect against A549 lung cancer cells, or the normal cells. Compound 7 caused cytotoxicity in MCF-7 breast cancer cells by apoptotic cell death, as suggested by fragmented nuclei after DAPI staining and agarose gel electrophoresis. In addition, treating MCF-7

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Sholikhah, Eti Nurwening, Jumina Jumina, Sitarina Widyarini, Ruslin Hadanu, and Mustofa Mustofa. "In vitro anticancer activity of N-benzyl 1,10-phenanthroline derivatives on human cancer cell lines and their selectivity." Indonesian Journal of Biotechnology 23, no. 2 (2018): 68. http://dx.doi.org/10.22146/ijbiotech.33997.

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This research was conducted to evaluate the anticancer activity of new compounds of benzyl-1,10- phenanthroline derivatives and their selectivity. In vitro anticancer activity of 11 benzyl-1,10-phenanthroline derivatives were conducted on three human cancer cell lines, cervical cancer (HeLa), myeloma (NS-1), and breast cancer (MCF-7) using MTT-based cytotoxicity assay. The cytotoxicity of each compound was assessed to normal Vero cell line by the same method. The in vitro anticancer activity and cytotoxicity was expressed by the concentration inhibiting 50% of the cell growth (IC50), and the s

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Durgesh, Rudavath, Sreenivasulu Reddymasu, Rao Pinapati Srinivasa, and Ramesh Raju Rudraraju. "Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives." Journal of India Chemical Society Vol. 95, Apr 2018 (2018): 433–38. https://doi.org/10.5281/zenodo.5642515.

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Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, Andhra Pradesh, India E-mail: rrraju1@gmail.com Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India <em>Manuscript received 24 February 2018, revised 01 March 2018, accepted 02 March 2018</em> A new series of hydrazide-hydrazones linked between indazole and substituted benzaldehydes were designed, synthesized and evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDAMB- 231, MCF-7 and A5

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Sinicropi, Maria Stefania, Cinzia Tavani, Camillo Rosano, et al. "A Nitrocarbazole as a New Microtubule-Targeting Agent in Breast Cancer Treatment." Applied Sciences 11, no. 19 (2021): 9139. http://dx.doi.org/10.3390/app11199139.

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Breast cancer is still considered a high-incidence disease, and numerous are the research efforts for the development of new useful and effective therapies. Among anticancer drugs, carbazole compounds are largely studied for their anticancer properties and their ability to interfere with specific targets, such as microtubule components. The latter are involved in vital cellular functions, and the perturbation of their dynamics leads to cell cycle arrest and subsequent apoptosis. In this context, we report the anticancer activity of a series of carbazole analogues 1–8. Among them, 2-nitrocarbaz

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Al-Bayati, Ammar I., Mahmood Ammar A. Razzak, Zainab A. Al-Mazaydeh, et al. "Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives." Pharmacia 68, no. (2) (2021): 449–61. https://doi.org/10.3897/pharmacia.68.e66788.

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Novel compounds (6–10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, <sup>1</sup>HNMR and CHNS. Their cytotoxic effect was evaluated by MTT assay against two cancer cell lines and two normal cell types. Compound 7 exhibited anticancer activity against MCF-7 breast cancer cell line (GI<sub>50</sub> = 63.9 µg/ml, 148 µM), without any effect against A549 lung cancer cells, or the normal cells. Compound 7 caused cytotoxicity in MCF-7 breast cancer cells by apoptotic cell death, as suggested by fragmented nuclei after DAPI staining and agarose gel electrophoresis. In ad

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Faraj, Fadhil Lafta, Maryam Zahedifard, Mohammadjavad Paydar, et al. "Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells." Scientific World Journal 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/212096.

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Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated for anticancer activity against MCF-7 human breast cancer cell line. Compounds 1 and 2 demonstrated a remarkable antiproliferative effect, with an IC50value of 6.246 × 10−6mol/L and 5.910 × 10−6mol/L, respectively, after 72 hours of treatment. Most apoptosis morphological features in treated MCF-7 cells were observed by AO/PI staining. The results of cell cycle analysis indicate that compounds did not induce S and M phase arrest in cell after 24 hours of treatment. Furthermore, MCF-7 cells treated with 1 a

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Uma, Rani Janapatla, Babu H. Ramesh, and M. Prashanthi. "One-pot synthesis and biological evaluation of novel 3-(5-((aryl) methyl) isoxazol-3-yl)-4H-chromen-4-one derivatives as potent antibacterial and anticancer agents." Research Journal of Chemistry and Environment 25, no. 11 (2021): 80–85. http://dx.doi.org/10.25303/2511rjce8085.

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In search of better antibacterial and anticancer agents, a series of novel 3-(5-((aryl) methyl) isoxazol-3-yl)-4Hchromen- 4-one derivatives was synthesized (4a-4l) by using 4-oxo-4H-chromene-3-carbaldehyde and alkyne via in situ generated nitrile oxide and evaluated for their antibacterial and anticancer activity in vitro. Antibacterial activity was evaluated against three G+ bacterial strains and anticancer activity against breast cancer cell line (MCF-7) and cervical carcinoma cell line (HeLa). Among all the tested compounds, 4j and 4g exhibited potent antibacterial activity against tested g

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Arsianti, Ade. "ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF GREEN SEAWEED ULVA LACTUCA TOWARDS MCF-7 BREAST CANCER CELLS." Jurnal Multidisiplin Indonesia 2, no. 6 (2023): 1133–48. http://dx.doi.org/10.58344/jmi.v2i6.264.

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Systematic researches for breast cancer are ran in Indonesia with its flora resources and therapeutic potentials as prospective towards cancer cells through studies concerning phytochemical contents, antioxidant activity, and cytotoxicity. The aim of this research is to obtain Ulva lactuca abundant potential that is available in Indonesia as antioxidant and anticancer towards breast cancer cell MCF-7. Ulva lactuca is extracted by maceration with solvents which are n-hexane, ethyl-acetate, and ethanol, ensuing extracts of n-hexane, ethyl-acetate and ethanol. The extracts later collected and tes

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Putram, Nurul Mutia, Iriani Setyaningsih, and Kustiariyah Tarman. "Anticancer Activity from Active Fraction of Sea Cucumber." Jurnal Pengolahan Hasil Perikanan Indonesia 20, no. 1 (2017): 53. http://dx.doi.org/10.17844/jphpi.v20i1.16399.

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Sea Cucumber Holothuria atra is one of marine organisms has been used as a new source of novel bioactive compounds. Many of them have been used as the lead compounds in discovery of new anticancer drugs. The objective of this study was to determine the active fractions of sea cucumber (H. atra) which have anticancer activity. H. atra was macerated using ethanol and the extract was freezedried using a freeze dryer. The crude extract was partitioned using n-hexane, ethyl acetate, and methanol-water (3:1:1:1). Cytotoxicity test was performed using HeLa (cervic cancer) cell line and MCF-7 (breast

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Kusumawardani, Banun, Qonita Nafilah Febi, Malihatul Rosidah, Deri Abdul Azis, Endah Puspitasari, and Ari Satia Nugraha. "Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells." Indonesian Journal of Cancer Chemoprevention 11, no. 2 (2020): 97. http://dx.doi.org/10.14499/indonesianjcanchemoprev11iss2pp97-10.

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Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco le

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Rzepka, Zuzanna, Ewa Bębenek, Elwira Chrobak, and Dorota Wrześniok. "Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin." Pharmaceutics 14, no. 11 (2022): 2372. http://dx.doi.org/10.3390/pharmaceutics14112372.

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Pentacyclic triterpenes, including betulin, are widespread natural products with various pharmacological effects. These compounds are the starting material for the synthesis of substances with promising anticancer activity. The chemical modification of the betulin scaffold that was carried out as part of the research consisted of introducing the indole moiety at the C-28 position. The synthesized new 28-indole-betulin derivatives were evaluated for anticancer activity against seven human cancer lines (A549, MDA-MB-231, MCF-7, DLD-1, HT-29, A375, and C32). It was observed that MCF-7 breast canc

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Gouda, Ahmed M., Ahmed H. Abdelazeem, Ashraf N. Abdalla, and Muhammad Ahmed. "Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities." Acta Pharmaceutica 68, no. 3 (2018): 251–73. http://dx.doi.org/10.2478/acph-2018-0026.

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Abstract Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4a-c and 5a-c) was prepared and evaluated for their anti-inflammatory, analgesic and anticancer activities. The (EZ)-7-cyano-6-((4-hydroxybenzylidene)amino)-N-(p-tolyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide (4b) and (EZ)-6-((4-chlorobenzylidene)-amino)-7-cyano-N-(p-tolyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide (5b) bearing the electron donating methyl group showed the highest anti-inflammatory activity while (EZ)-6-((4-chlorobenzylidene)amino)-7-cyano-N-phenyl-2,3-dihydro-1H-pyrroli

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Sami, Fitriyanti Jumaetri, and Syamsu Nur. "Isolation, identification and biochemical studies of gallic acid from Turbinaria decurrens Bory." Current Research on Biosciences and Biotechnology 4, no. 1 (2022): 238–41. http://dx.doi.org/10.5614/crbb.2022.4.1/x7dd09ry.

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Cancer is one of the diseases that cause the biggest death in the world. The research for natural compounds derived from marine is very developed at this time, especially in algae. Brown algae have more phenolic content than other types of algae, T. decurrens Bory is one of the brown algae that had taken from the Indonesian island of Dutungan, South Sulawesi. Phenolic groups are also known to be able to inhibit the growth of cancer cells. The purpose of this study is to isolate and identify compounds using spectrophotometer instruments. The isolates obtained were tested for anticancer activity

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