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Journal articles on the topic 'Anticancer peptides'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Ng, Chu Xin, and Sau Har Lee. "The Potential Use of Anticancer Peptides (ACPs) in the Treatment of Hepatocellular Carcinoma." Current Cancer Drug Targets 20, no. 3 (2020): 187–96. http://dx.doi.org/10.2174/1568009619666191111141032.

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Peptides have acquired increasing interest as promising therapeutics, particularly as anticancer alternatives during recent years. They have been reported to demonstrate incredible anticancer potentials due to their low manufacturing cost, ease of synthesis and great specificity and selectivity. Hepatocellular carcinoma (HCC) is among the leading cause of cancer death globally, and the effectiveness of current liver treatment has turned out to be a critical issue in treating the disease efficiently. Hence, new interventions are being explored for the treatment of hepatocellular carcinoma. Anti

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2

Gabernet, G., A. T. Müller, J. A. Hiss, and G. Schneider. "Membranolytic anticancer peptides." MedChemComm 7, no. 12 (2016): 2232–45. http://dx.doi.org/10.1039/c6md00376a.

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3

Arias, Mauricio, Ashley L. Hilchie, Evan F. Haney, et al. "Anticancer activities of bovine and human lactoferricin-derived peptides." Biochemistry and Cell Biology 95, no. 1 (2017): 91–98. http://dx.doi.org/10.1139/bcb-2016-0175.

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Lactoferrin (LF) is a mammalian host defense glycoprotein with diverse biological activities. Peptides derived from the cationic region of LF possess cytotoxic activity against cancer cells in vitro and in vivo. Bovine lactoferricin (LFcinB), a peptide derived from bovine LF (bLF), exhibits broad-spectrum anticancer activity, while a similar peptide derived from human LF (hLF) is not as active. In this work, several peptides derived from the N-terminal regions of bLF and hLF were studied for their anticancer activities against leukemia and breast-cancer cells, as well as normal peripheral bloo

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Juretić, Davor, Anja Golemac, Denise E. Strand, et al. "The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells." Molecules 25, no. 15 (2020): 3526. http://dx.doi.org/10.3390/molecules25153526.

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The link between the antimicrobial and anticancer activity of peptides has long been studied, and the number of peptides identified with both activities has recently increased considerably. In this work, we hypothesized that designed peptides with a wide spectrum of selective antimicrobial activity will also have anticancer activity, and tested this hypothesis with newly designed peptides. The spectrum of peptides, used as partial or full design templates, ranged from cell-penetrating peptides and putative bacteriocin to those from the simplest animals (placozoans) and the Chordata phylum (anu

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Liscano, Yamil, Jose Oñate-Garzón, and Jean Paul Delgado. "Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides." Molecules 25, no. 18 (2020): 4245. http://dx.doi.org/10.3390/molecules25184245.

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Peptides are naturally produced by all organisms and exhibit a wide range of physiological, immunomodulatory, and wound healing functions. Furthermore, they can provide with protection against microorganisms and tumor cells. Their multifaceted performance, high selectivity, and reduced toxicity have positioned them as effective therapeutic agents, representing a positive economic impact for pharmaceutical companies. Currently, efforts have been made to invest in the development of new peptides with antimicrobial and anticancer properties, but the poor stability of these molecules in physiologi

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6

Aaghaz, Shams, Vivek Gohel, and Ahmed Kamal. "Peptides as Potential Anticancer Agents." Current Topics in Medicinal Chemistry 19, no. 17 (2019): 1491–511. http://dx.doi.org/10.2174/1568026619666190125161517.

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Cancer consists of heterogeneous multiple cell subpopulation which at a later stage develop resistant phenotypes, which include resistance to pro-apoptotic stimuli and/or cytotoxic resistance to anticancer compounds. The property of cancerous cells to affect almost any part of the body categorizes cancer to many anatomic and molecular subtypes, each requiring a particular therapeutic intervention. As several modalities are hindered in a variety of cancers and as the cancer cells accrue varied types of oncogenic mutations during their progression the most likely benefit will be obtained by a co

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7

Sun, Zhi-Gang, Zhi-Na Li, Bao-Chan Yang, and Liang-Hui Zhao. "Design and Synthesis of Novel Anticancer Peptide Nanoparticles." Journal of Drug Delivery and Therapeutics 10, no. 4 (2020): 102–7. http://dx.doi.org/10.22270/jddt.v10i4.4156.

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Cancer has now become a common disease affecting human health. Existing cancer treatment drugs can no longer meet the growing needs of cancer patients, and the emergence of anticancer drug resistance has exacerbated this phenomenon. By designing and synthesizing new anticancer peptide nanoparticles and studying their anticancer effects, new strategies for cancer treatment may be obtained. Novel anticancer peptides are synthesized by adding basic amino acids and solid-phase synthesis technology, and their structural information is determined by mass spectrometry. Nanoparticles of anticancer pep

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8

Torres, Marcelo D. T., Gislaine P. Andrade, Roseli H. Sato, et al. "Natural and redesigned wasp venom peptides with selective antitumoral activity." Beilstein Journal of Organic Chemistry 14 (July 6, 2018): 1693–703. http://dx.doi.org/10.3762/bjoc.14.144.

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About 1 in 8 U.S. women (≈12%) will develop invasive breast cancer over the course of their lifetime. Surgery, chemotherapy, radiotherapy, and hormone manipulation constitute the major treatment options for breast cancer. Here, we show that both a natural antimicrobial peptide (AMP) derived from wasp venom (decoralin, Dec-NH2), and its synthetic variants generated via peptide design, display potent activity against cancer cells. We tested the derivatives at increasing doses and observed anticancer activity at concentrations as low as 12.5 μmol L−1 for the selective targeting of MCF-7 breast ca

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Hilchie, Ashley L., Erin E. Gill, Melanie R. Power Coombs, Reza Falsafi, Robert E. W. Hancock, and David W. Hoskin. "MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity." Biomolecules 10, no. 9 (2020): 1220. http://dx.doi.org/10.3390/biom10091220.

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Direct-acting anticancer (DAA) peptides are cytolytic peptides that show promise as novel anticancer agents. DAA peptides bind to anionic molecules that are abundant on cancer cells relative to normal healthy cells, which results in preferential killing of cancer cells. Due to the mechanism by which DAA peptides kill cancer cells, it was thought that resistance would be difficult to achieve. Here, we describe the generation and characterization of two MDA-MB-231 breast cancer cell-line variants with reduced susceptibility to pleurocidin-family and mastoparan DAA peptides. Peptide resistance co

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10

Soon, Tsuey Ning, Adeline Yoke Yin Chia, Wei Hsum Yap, and Yin-Quan Tang. "Anticancer Mechanisms of Bioactive Peptides." Protein & Peptide Letters 27, no. 9 (2020): 823–30. http://dx.doi.org/10.2174/0929866527666200409102747.

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: Despite technological advancement, there is no 100% effective treatment against metastatic cancer. Increasing resistance of cancer cells towards chemotherapeutic drugs along with detrimental side effects remained a concern. Thus, the urgency in developing new anticancer agents has been raised. Anticancer peptides have been proven to display potent activity against a wide variety of cancer cells. Several mode of actions describing their cytostatic and cytotoxic effect on cancer cells have been proposed which involves cell surface binding leading to membranolysis or internalization to reach th

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11

Lin, Yen-Chu, Yi Fan Lim, Erica Russo, et al. "Multidimensional Design of Anticancer Peptides." Angewandte Chemie International Edition 54, no. 35 (2015): 10370–74. http://dx.doi.org/10.1002/anie.201504018.

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12

Gross, Stephanie, and Jörg Andrä. "Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids." Biological Chemistry 393, no. 8 (2012): 817–27. http://dx.doi.org/10.1515/hsz-2012-0136.

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Abstract Some antimicrobial peptides have emerged as potential anticancer agents. In contrast to chemotherapeutics, they act primarily by physical disruption of the cancer cell membrane. Selective targeting of these cationic peptides still remains elusive. We focus on the interaction of α-helical peptides NK-2, cathelicidin LL32, and melittin with PC-3 prostate cancer cells, and we provide strong evidence that, amongst the anionic glycans covering the cell surface, sulphated carbohydrates rather than sialic acids are the preferred interaction sites of the peptides. To test the significance of

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Garizo, Ana Rita, Lígia F. Coelho, Sandra Pinto, et al. "The Azurin-Derived Peptide CT-p19LC Exhibits Membrane-Active Properties and Induces Cancer Cell Death." Biomedicines 9, no. 9 (2021): 1194. http://dx.doi.org/10.3390/biomedicines9091194.

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Peptides have been thoroughly studied as new therapeutic strategies for cancer treatment. In this work, we explored in vitro the anticancer potential of three novel peptides derived from the C-terminal of azurin, an anticancer bacterial protein produced by Pseudomonas aeruginosa. CT-p26, CT-p19 and CT-p19LC peptides were previously obtained through an in silico peptide design optimization process, CT-p19LC being the most promising as it presented higher hydrophobicity and solubility, positive total charge and, most importantly, greater propensity for anticancer activity. Therefore, in this stu

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14

Feng, Pengmian, and Zhenyi Wang. "Recent Advances in Computational Methods for Identifying Anticancer Peptides." Current Drug Targets 20, no. 5 (2019): 481–87. http://dx.doi.org/10.2174/1389450119666180801121548.

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Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniques, a series of computational methods have been proposed for identifying ACPs. In this review, we briefly summarized the current progress in computational identification of ACPs. The challenges and future perspectives in developing reliable methods for identification of ACPs were

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15

Qin, Yuan, Zuo D. Qin, Jing Chen, et al. "From Antimicrobial to Anticancer Peptides: The Transformation of Peptides." Recent Patents on Anti-Cancer Drug Discovery 14, no. 1 (2019): 70–84. http://dx.doi.org/10.2174/1574892814666190119165157.

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Background: Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positive bacteria, fungi, and tumor cells.Objective:An overview of the state of play with regard to the research trend of antimicrobial peptides in recent years and the situation of targeting tumor cells, and to make statistical analysis of the patents related to anticancer peptides published in recent years, is important both from toxicological and medic

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16

Shahidi, Fereidoon, and Ying Zhong. "Bioactive Peptides." Journal of AOAC INTERNATIONAL 91, no. 4 (2008): 914–31. http://dx.doi.org/10.1093/jaoac/91.4.914.

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Abstract Peptides with biological activities, released during gastrointestinal digestion or food processing, play an important role in metabolic regulation and modulation, suggesting their potential use as nutraceuticals and functional food ingredients for health promotion and disease risk reduction. Many studies have reported that peptides from various food sources possess bioactivities, including antihypertensive, antioxidant, anticancer, antimicrobial, and opioid activities as well as immunomodulatory and cholesterol-lowering effects. More studies are being performed exploring the sources,

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17

Vernen, Felicitas, Peta J. Harvey, Susana A. Dias, et al. "Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties." International Journal of Molecular Sciences 20, no. 17 (2019): 4184. http://dx.doi.org/10.3390/ijms20174184.

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Tachyplesin I, II and III are host defense peptides from horseshoe crab species with antimicrobial and anticancer activities. They have an amphipathic β-hairpin structure, are highly positively-charged and differ by only one or two amino acid residues. In this study, we compared the structure and activity of the three tachyplesin peptides alongside their backbone cyclized analogues. We assessed the peptide structures using nuclear magnetic resonance (NMR) spectroscopy, then compared the activity against bacteria (both in the planktonic and biofilm forms) and a panel of cancerous cells. The imp

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18

Feng, Jue-Ping, Ru Zhu, Fagang Jiang, et al. "Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides." Biomaterials Science 8, no. 16 (2020): 4559–69. http://dx.doi.org/10.1039/c9bm02080b.

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19

Rubin, Samuel J. S., and Nir Qvit. "Engineering “Antimicrobial Peptides” and Other Peptides to Modulate Protein-Protein Interactions in Cancer." Current Topics in Medicinal Chemistry 20, no. 32 (2020): 2970–83. http://dx.doi.org/10.2174/1568026620666201021141401.

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Antimicrobial peptides (AMPs) are a class of peptides found across a wide array of organisms that play key roles in host defense. AMPs induce selective death in target cells and orchestrate specific or nonspecific immune responses. Many AMPs exhibit native anticancer activity in addition to antibacterial activity, and others have been engineered as antineoplastic agents. We discuss the use of AMPs in the detection and treatment of cancer as well as mechanisms of AMP-induced cell death. We present key examples of cathelicidins and transferrins, which are major AMP families. Further, we discuss

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20

Dąbrowska, Krystyna, Zuzanna Kaźmierczak, Joanna Majewska, et al. "Bacteriophages displaying anticancer peptides in combined antibacterial and anticancer treatment." Future Microbiology 9, no. 7 (2014): 861–69. http://dx.doi.org/10.2217/fmb.14.50.

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21

Feng, Jue-Ping, Ru Zhu, Fagang Jiang, et al. "Correction: Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides." Biomaterials Science 8, no. 21 (2020): 6100. http://dx.doi.org/10.1039/d0bm90081h.

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Correction for ‘Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides’ by Jue-Ping Feng et al., Biomater. Sci., 2020, 8, 4559–4569, DOI: 10.1039/C9BM02080B.

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22

Chantawannakul, Jarinyagon, Paninnuch Chatpattanasiri, Vichugorn Wattayagorn, Mesayamas Kongsema, Tipanart Noikaew, and Pramote Chumnanpuen. "Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line." Molecules 26, no. 19 (2021): 5767. http://dx.doi.org/10.3390/molecules26195767.

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Colorectal cancer is one of the leading causes of cancer-related death in Thailand and many other countries. The standard practice for curing this cancer is surgery with an adjuvant chemotherapy treatment. However, the unfavorable side effects of chemotherapeutic drugs are undeniable. Recently, protein hydrolysates and anticancer peptides have become popular alternative options for colon cancer treatment. Therefore, we aimed to screen and select the anticancer peptide candidates from the in silico pepsin hydrolysate of a Cordyceps militaris (CM) proteome using machine-learning-based prediction

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23

Janin, Y. L. "Peptides with anticancer use or potential." Amino Acids 25, no. 1 (2003): 1–40. http://dx.doi.org/10.1007/s00726-002-0349-x.

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24

Karbalaeemohammad, Shahrbanoo, and Hossein Naderi-Manesh. "Two Novel Anticancer Peptides from Aurein1.2." International Journal of Peptide Research and Therapeutics 17, no. 3 (2011): 159–64. http://dx.doi.org/10.1007/s10989-011-9253-0.

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25

Sharma, Ravi D., Jainendra Jain, and Ratan L. Khosa. "Design, Synthesis and Anticancer Activity of Site Specific Short Chain Cationic Peptide." Current Drug Discovery Technologies 17, no. 5 (2020): 631–46. http://dx.doi.org/10.2174/1570163816666190402121033.

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Background: In spite of current progress in treatment methods, cancer is a major source of morbidity and death rate all over the world. Traditional chemotherapeutic agents aim to divide cancerous cells, are often associated with deleterious side effects to healthy cells and tissues. Host defense peptides Cecropin A and B obtained from insects are capable to lyses various types of human cancer cells at peptide concentrations which are not fatal to normal eukaryotic cells. Methods: In the present work we have designed short chain α-helical linear and cyclic peptide from cecropin A having same ca

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26

Zhang, Qi-Ting, Ze-Dong Liu, Ze Wang, et al. "Recent Advances in Small Peptides of Marine Origin in Cancer Therapy." Marine Drugs 19, no. 2 (2021): 115. http://dx.doi.org/10.3390/md19020115.

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Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, th

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27

Wootton, Christopher A., Carlos Sanchez-Cano, Andrea F. Lopez-Clavijo, et al. "Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes." Chemical Science 9, no. 10 (2018): 2733–39. http://dx.doi.org/10.1039/c7sc05135b.

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Octahedral anticancer platinum(iv) complexes such as trans,trans,trans-[Pt(N<sub>3</sub>)<sub>2</sub>(OH)<sub>2</sub>(pyridine)<sub>2</sub>] (1) can target peptides (and proteins) by sequence-dependent platination and radical mechanisms when activated by UVA or visible light; the specific products are highly dependent on their amino acid composition of the peptide.

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Wu, Qihui, Hanzhong Ke, Dongli Li, Qi Wang, Jiansong Fang, and Jingwei Zhou. "Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery." Current Topics in Medicinal Chemistry 19, no. 1 (2019): 4–16. http://dx.doi.org/10.2174/1568026619666190122151634.

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Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Compared to organic small drugs, peptide- based therapy exhibits high specificity and minimal toxicity. Thus, peptides are widely recr

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29

Zhao, Yuhong, Shijing Wang, Wenyi Fei, et al. "Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides." International Journal of Molecular Sciences 22, no. 11 (2021): 5630. http://dx.doi.org/10.3390/ijms22115630.

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Recently, anticancer peptides (ACPs) have emerged as unique and promising therapeutic agents for cancer treatment compared with antibody and small molecule drugs. In addition to experimental methods of ACPs discovery, it is also necessary to develop accurate machine learning models for ACP prediction. In this study, features were extracted from the three-dimensional (3D) structure of peptides to develop the model, compared to most of the previous computational models, which are based on sequence information. In order to develop ACPs with more potency, more selectivity and less toxicity, the mo

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Guzmán-Rodríguez, Jaquelina Julia, Alejandra Ochoa-Zarzosa, Rodolfo López-Gómez, and Joel E. López-Meza. "Plant Antimicrobial Peptides as Potential Anticancer Agents." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/735087.

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Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms and are promising candidates to treat infections caused by pathogenic bacteria to animals and humans. AMPs also display anticancer activities because of their ability to inactivate a wide range of cancer cells. Cancer remains a cause of high morbidity and mortality worldwide. Therefore, the development of methods for its control is desirable. Attractive alternatives include plant AMP thionins, defensins, and cyclotides, which have anticancer activities. Here, we provide an overview of plant AMPs ant

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Mehrotra, Neha, Surender Kharbanda, and Harpal Singh. "Peptide-based combination nanoformulations for cancer therapy." Nanomedicine 15, no. 22 (2020): 2201–17. http://dx.doi.org/10.2217/nnm-2020-0220.

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Research in cancer therapy is moving towards the use of biomolecules in combination with conventional approaches for improved disease outcome. Among the biomolecules explored, peptides are strong contenders due to their small size, high specificity, low systemic toxicity and wide inter/intracellular targets. The use of nanoformulations for such combination approaches can lead to further improvement in efficacy by reducing off-target cytotoxicity, increasing circulation time, tumor penetration and accumulation. This review focuses on nanodelivery systems for peptide-based combinations with chem

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Wang, Yicun, Shuohui Gao, Jiayin Lv, Yang Lin, Li Zhou, and Liying Han. "Phage Display Technology and its Applications in Cancer Immunotherapy." Anti-Cancer Agents in Medicinal Chemistry 19, no. 2 (2019): 229–35. http://dx.doi.org/10.2174/1871520618666181029140814.

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Background:Phage display is an effective technology for generation and selection targeting protein for a variety of purpose, which is based on a direct linkage between the displayed protein and the DNA sequence encoding it and utilized in selecting peptides, improving peptides affinity and indicating protein-protein interactions. Phage particles displaying peptide have the potential to apply in the identification of cell-specific targeting molecules, identification of cancer cell surface biomarkers, identification anti-cancer peptide, and the design of peptide-based anticancer therapy.Method/R

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Jabeen, Farukh, Siva S. Panda, Tamara P. Kondratyuk, et al. "Synthesis, molecular docking and anticancer studies of peptides and iso-peptides." Bioorganic & Medicinal Chemistry Letters 25, no. 15 (2015): 2980–84. http://dx.doi.org/10.1016/j.bmcl.2015.05.020.

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S. Liberio, M., G. A. Joanitti, W. Fontes, and M. S. Castro. "Anticancer Peptides and Proteins: A Panoramic View." Protein & Peptide Letters 20, no. 4 (2013): 380–91. http://dx.doi.org/10.2174/092986613805290435.

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S. Liberio, M., G. A. Joanitti, W. Fontes, and M. S. Castro. "Anticancer Peptides and Proteins: A Panoramic View." Protein & Peptide Letters 20, no. 4 (2013): 380–91. http://dx.doi.org/10.2174/0929866511320040002.

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Raucher, Drazen, and Jung Su Ryu. "Cell-penetrating peptides: strategies for anticancer treatment." Trends in Molecular Medicine 21, no. 9 (2015): 560–70. http://dx.doi.org/10.1016/j.molmed.2015.06.005.

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Karpiński, Tomasz, and Artur Adamczak. "Anticancer Activity of Bacterial Proteins and Peptides." Pharmaceutics 10, no. 2 (2018): 54. http://dx.doi.org/10.3390/pharmaceutics10020054.

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Prabhu, Saurabh, Sarah R. Dennison, Bob Lea, et al. "Anionic Antimicrobial and Anticancer Peptides from Plants." Critical Reviews in Plant Sciences 32, no. 5 (2013): 303–20. http://dx.doi.org/10.1080/07352689.2013.773238.

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39

Li, Xuan Liu and Yi. "Mechanism of Anticancer Effects of Antimicrobial Peptides." Journal of Fiber Bioengineering and Informatics 8, no. 1 (2015): 25–36. http://dx.doi.org/10.3993/jfbi03201503.

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Grisoni, Francesca, Claudia S. Neuhaus, Gisela Gabernet, Alex T. Müller, Jan A. Hiss, and Gisbert Schneider. "Designing Anticancer Peptides by Constructive Machine Learning." ChemMedChem 13, no. 13 (2018): 1300–1302. http://dx.doi.org/10.1002/cmdc.201800204.

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Aluri, Suhaas, Siti M. Janib, and J. Andrew Mackay. "Environmentally responsive peptides as anticancer drug carriers☆." Advanced Drug Delivery Reviews 61, no. 11 (2009): 940–52. http://dx.doi.org/10.1016/j.addr.2009.07.002.

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42

Ganesan, Sai Janani, Joel P. Schneider, Robert Blumenthal, and Silvina Matysiak. "Characterization of Anticancer Peptides in Membrane Disruption." Biophysical Journal 104, no. 2 (2013): 597a. http://dx.doi.org/10.1016/j.bpj.2012.11.3314.

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43

Hoskin, David W., and Ayyalusamy Ramamoorthy. "Studies on anticancer activities of antimicrobial peptides." Biochimica et Biophysica Acta (BBA) - Biomembranes 1778, no. 2 (2008): 357–75. http://dx.doi.org/10.1016/j.bbamem.2007.11.008.

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44

Teng, Qiu-Xu, Xiaofang Luo, Zi-Ning Lei, et al. "The Multidrug Resistance-Reversing Activity of a Novel Antimicrobial Peptide." Cancers 12, no. 7 (2020): 1963. http://dx.doi.org/10.3390/cancers12071963.

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The overexpression of ATP-binding cassette (ABC) transporters is a common cause of multidrug resistance (MDR) in cancers. The intracellular drug concentration of cancer cells can be decreased relative to their normal cell counterparts due to increased expression of ABC transporters acting as efflux pumps of anticancer drugs. Over the past decades, antimicrobial peptides have been investigated as a new generation of anticancer drugs and some of them were reported to have interactions with ABC transporters. In this article, we investigated several novel antimicrobial peptides to see if they coul

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Huang, Yibing, Qi Feng, Qiuyan Yan, Xueyu Hao, and Yuxin Chen. "Alpha-Helical Cationic Anticancer Peptides: A Promising Candidate for Novel Anticancer Drugs." Mini-Reviews in Medicinal Chemistry 15, no. 1 (2015): 73–81. http://dx.doi.org/10.2174/1389557514666141107120954.

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46

Wong, Daniel Yuan Qiang, Jun Han Lim, and Wee Han Ang. "Induction of targeted necrosis with HER2-targeted platinum(iv) anticancer prodrugs." Chemical Science 6, no. 5 (2015): 3051–56. http://dx.doi.org/10.1039/c5sc00015g.

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Platinum(iv) prodrug complexes based on the cisplatin/oxaliplatin pharmacophore, containing anti-HER2/neu targeting peptides, were designed to deliver their cytotoxic platinum(ii) payload selectively to highly HER2-expressing cells. Through induction of necrotic cell death, these platinum(iv)–peptide conjugates can circumvent apoptosis-resistance pathways in targeted HER2-positive cells.

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47

Kardani, Kimia, and Azam Bolhassani. "Antimicrobial/anticancer peptides: bioactive molecules and therapeutic agents." Immunotherapy 13, no. 8 (2021): 669–84. http://dx.doi.org/10.2217/imt-2020-0312.

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Antimicrobial peptides (AMPs) have been known as host-defense peptides. These cationic and amphipathic peptides are relatively short (∼5–50 L-amino acids) with molecular weight less than 10 kDa. AMPs have various roles including immunomodulatory, angiogenic and antitumor activities. Anticancer peptides (ACPs) are a main subset of AMPs as a novel therapeutic approach against tumor cells. The physicochemical properties of the ACPs influence their cell penetration, stability and efficiency of targeting. Up to now, several databases and web servers for in silico prediction of AMPs/ACPs have been e

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Wang, Hua, Ya-Qiong Yan, Yu Yi, et al. "Supramolecular Peptide Therapeutics: Host–Guest Interaction-Assisted Systemic Delivery of Anticancer Peptides." CCS Chemistry 2, no. 6 (2020): 739–48. http://dx.doi.org/10.31635/ccschem.020.202000283.

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Kotamraju, Venkata Ramana, Shweta Sharma, Poornima Kolhar, Lilach Agemy, James Pavlovich, and Erkki Ruoslahti. "Increasing Tumor Accessibility with Conjugatable Disulfide-Bridged Tumor-Penetrating Peptides for Cancer Diagnosis and Treatment." Breast Cancer: Basic and Clinical Research 9s2 (January 2015): BCBCR.S29426. http://dx.doi.org/10.4137/bcbcr.s29426.

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Tumor-homing peptides with tissue-penetrating properties increase the efficacy of targeted cancer therapy by delivering an anticancer agent to the tumor interior. LyP-1 (CGNKRTRGC) and iRGD (CRGDKGPDC) are founding members of this class of peptides. The presence of the cysteines forming the cyclizing disulfide bond complicates conjugation of these peptides with other molecules, such as drugs. Here, we report the synthesis of conjugatable disulfide-bridged peptides and their conjugation to biologically important molecules. We have synthesized the LyP-1, iRGD, and CRGDC (GACRGDCLGA) peptides wit

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Jeyamogan, Shareni, Naveed A. Khan, Kuppusamy Sagathevan, and Ruqaiyyah Siddiqui. "Anticancer Properties of Asian Water Monitor Lizard (Varanus salvator), Python (Malayopython reticulatus) and Tortoise (Cuora kamaroma amboinensis)." Anti-Cancer Agents in Medicinal Chemistry 20, no. 13 (2020): 1558–70. http://dx.doi.org/10.2174/1871520620666200504103056.

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Background: Cancer contributes to significant morbidity and mortality despite advances in treatment and supportive care. There is a need for the identification of effective anticancer agents. Reptiles such as tortoise, python, and water monitor lizards are exposed to heavy metals, tolerate high levels of radiation, feed on rotten/germ-infested feed, thrive in unsanitary habitat and yet have prolonged lifespans. Such species are rarely reported to develop cancer, suggesting the presence of anticancer molecules/mechanisms. Methods: Here, we tested effects from sera of Asian water monitor lizard

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