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Journal articles on the topic 'Anticancer Secondary Metabolites'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 September 2023

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1

Uras, İbrahim Seyda, and Belma Konuklugil. "Anticancer secondary metabolites from marine sponges." Ege Journal of Fisheries and Aquatic Sciences 38, no. 1 (2021): 101–6. http://dx.doi.org/10.12714/egejfas.38.1.12.

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The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. Cancer is one of the leading causes of death with high morbidity and mortality. It is very important to discover new therapeutic agents in the treatment of cancer. In recent years, studies on exploring new anticancer compounds are focused on the marine source. In this review, our target is collecting the studies about marine spong
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2

Solárová, Zuzana, Alena Liskova, Marek Samec, Peter Kubatka, Dietrich Büsselberg, and Peter Solár. "Anticancer Potential of Lichens’ Secondary Metabolites." Biomolecules 10, no. 1 (2020): 87. http://dx.doi.org/10.3390/biom10010087.

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Lichens produce different classes of phenolic compounds, including anthraquinones, xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed effective biological activities such as antioxidant, antiviral, antibiotics, antifungal, and anticancer. Although no clinical study has been conducted yet, there are number of in vitro and in vivo studies demonstrating anticancer effects of lichen metabolites. The main goal of our work was to review most recent published papers dealing with anticancer activities of secondary metabolites of lichens and point out to their perspective cl
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3

Evidente, Antonio, Alexander Kornienko, Alessio Cimmino, et al. "Fungal metabolites with anticancer activity." Nat. Prod. Rep. 31, no. 5 (2014): 617–27. http://dx.doi.org/10.1039/c3np70078j.

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4

Simko, Patrik, and Terezia Kiskova. "Uncovering the Anticancer Potential of Lichen Secondary Metabolites." Journal of Analytical Oncology 11 (December 14, 2022): 70–78. http://dx.doi.org/10.30683/1927-7229.2022.11.10.

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Lichens produce a plethora of primary and secondary metabolites. Secondary metabolites have several biological functions that can be used for human health. Recent studies have described their antioxidant, anti-inflammatory, antimycotic, and antibiotic/antiviral activities. However, attention has mainly been focused on their antiproliferative, cytotoxic, and anticancer effects. Because there are many publications describing the molecular mechanisms leading to the anticancer effects of lichen secondary metabolites, the aim of this review is to summarize results from current research with the mai
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Mohammadi, Mehdi, Moj Khaleghi, Shahriyar Shakeri, Majid Askari Hesni, Mohammad Rasoul Samandari-Bahraseman, and Ava Dalvand. "Isolation of Actinobacteria Strains From Environmental Samples and Assessment of Their Bioactivity." Avicenna Journal of Clinical Microbiology and Infection 9, no. 1 (2022): 18–25. http://dx.doi.org/10.34172/ajcmi.2022.03.

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Background: Actinobacteria are widespread and live in a variety of habitats. Today, these bacteria are very important due to the production of various secondary metabolites with different biological activities. The present study aimed to isolate strains of Actinobacteria from different habitats (the Persian Gulf, Gandom Beryan area in the Lut Desert, and some plant roots). The anticancer and antimicrobial activities of secondary metabolites of these isolates were also investigated. Methods: Samples were taken from water of the Persian Gulf, soil of Gandom Beryan area in the Lut Desert, and pla
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Sevastre, Ani-Simona, Elena Victoria Manea, Oana Stefana Popescu, et al. "Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy." International Journal of Molecular Sciences 23, no. 17 (2022): 9943. http://dx.doi.org/10.3390/ijms23179943.

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Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating
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Pham, Van Thuy Thi, Chung Thanh Nguyen, Dipesh Dhakal, Hue Thi Nguyen, Tae-Su Kim, and Jae Kyung Sohng. "Recent Advances in the Heterologous Biosynthesis of Natural Products from Streptomyces." Applied Sciences 11, no. 4 (2021): 1851. http://dx.doi.org/10.3390/app11041851.

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Streptomyces is a significant source of natural products that are used as therapeutic antibiotics, anticancer and antitumor agents, pesticides, and dyes. Recently, with the advances in metabolite analysis, many new secondary metabolites have been characterized. Moreover, genome mining approaches demonstrate that many silent and cryptic biosynthetic gene clusters (BGCs) and many secondary metabolites are produced in very low amounts under laboratory conditions. One strain many compounds (OSMAC), overexpression/deletion of regulatory genes, ribosome engineering, and promoter replacement have bee
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8

Udayan, E., and Joel J. Gnanadoss. "Potential of endophytic fungi as therapeutics: Antibiotics, Antiviral and Anticancer properties." Research Journal of Biotechnology 18, no. 6 (2023): 132–45. http://dx.doi.org/10.25303/1806rjbt1320145.

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Antibiotic resistance, an emerging threat to human health, is the world's major challenge today. Endophytic microbes found in medicinal plants aid in the resolution of these issues. It is critical to select the plant that will be used to investigate endophytes for bioactive metabolites. As a result, medicinal plants which have been used as a traditional source of medicine for centuries, are a valuable source for bioprospecting endophytes. Fungi are the most commonly reported organisms among endophytes. Endophytic fungi are a diverse group of microbes that invade plant interior tissues without
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9

Sugita, Purwantiningsih, Dina Anggraini, Gustini Syahbirin, Dyah Utami Cahayaning Rahayu, and Auliya Ilmiawati. "Secondary Metabolites from Indonesian Kigelia africana (Bignoniaceae)." Journal of the Indonesian Chemical Society 2, no. 2 (2019): 114. http://dx.doi.org/10.34311/jics.2019.02.2.114.

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From the fruit of Kigelia africana three fractions of secondary metabolites were isolated. Fraction 1 (CD-1) was characterized by using UV-Vis, FTIR, 1D and 2D NMR and MS, meanwhile fraction 2 (CD-2) and 3 (B-1) were characterized by LCMS and compared with literature. All these fractions were screened for anticancer activity by using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method to calculate IC50 toward Michigan Cancer Foundation-7 MCF-7 breast cancer and menogaril-resistant mouse leukemia P388 cells. Based on spectroscopic data, CD-1 fraction was identified as me
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10

Maya Dian Rakhmawatie, Maya Dian Rakhmawatie, Mustofa Mustofa, Puspita Lisdiyanti Puspita Lisdiyanti, Woro Rukmi Pratiwi Woro Rukmi Pratiwi, and Tri Wibawa Tri Wibawa. "Identification of Antimycobacterial from Actinobacteria (INACC A758) Secondary Metabolites using Metabolomics Data." Sains Malaysiana 51, no. 5 (2022): 1465–73. http://dx.doi.org/10.17576/jsm-2022-5105-16.

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Actinobacteria produce active secondary metabolite with medicinal properties, such as antibacterial or anticancer. However, there are some reports about the difficulties in discovering novel secondary metabolites. Therefore, the need for a new approach is obvious. Several factors such as types of nutrients in the culture media or different solvents used for extraction have been proven to influence the Actinobacteria secondary metabolite production. In this study, a combination of culture media optimization and metabolites fingerprint analysis were applied to identify antimycobacterial active c
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11

Balde, ElHadj Saidou, Anna Andolfi, Céline Bruyère, et al. "Investigations of Fungal Secondary Metabolites with Potential Anticancer Activity." Journal of Natural Products 73, no. 5 (2010): 969–71. http://dx.doi.org/10.1021/np900731p.

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12

Chen, Wei, and Qiongbo Hu. "Secondary Metabolites of Purpureocillium lilacinum." Molecules 27, no. 1 (2021): 18. http://dx.doi.org/10.3390/molecules27010018.

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Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and
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13

Pirog, T. P. "MICROBIAL CO-CULTIVATION: DISCOVERY OF NOVEL SECONDARY METABOLITES WITH DIFFERENT BIOLOGICAL ACTIVITIES." Biotechnologia Acta 16, no. 1 (2023): 21–39. http://dx.doi.org/10.15407/biotech16.01.021.

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In recent decades, overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making them a major problem for humanity. One of the most effective approaches to the discovery of new secondary antimicrobial metabolites is co-cultivation of microorganisms, in which the producer of the target products is grown together with competitive microorganisms ( inductors), in response to the presence of which silent biosynthetic genes of the producer strain are activated and an increase in the biological activity of the synthesized
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14

Wu, Chu, Yun Wang, and Yujie Yang. "Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities." Molecules 27, no. 22 (2022): 8088. http://dx.doi.org/10.3390/molecules27228088.

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Pestalotiopsis species have gained attention thanks to their structurally complex and biologically active secondary metabolites. In past decades, several new secondary metabolites were isolated and identified. Their bioactivities were tested, including anticancer, antifungal, antibacterial, and nematicidal activity. Since the previous review published in 2014, new secondary metabolites were isolated and identified from Pestalotiopsis species and unidentified strains. This review gathered published articles from 2014 to 2021 and focused on 239 new secondary metabolites and their bioactivities.
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15

Kinghorn, A. "Plant Secondary Metabolites as Potential Anticancer Agents and Cancer Chemopreventives." Molecules 5, no. 12 (2000): 285–88. http://dx.doi.org/10.3390/50300285.

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16

Rocha, Djenisa, Ana Seca, and Diana Pinto. "Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity." Marine Drugs 16, no. 11 (2018): 410. http://dx.doi.org/10.3390/md16110410.

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Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have ca
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17

Bondarenko, Vladimir, and Ky Raymond. "Anticancer Properties of Secondary Metabolites Isolated from Lichen Parmelia vagans." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.05611.

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18

Ghaderi, F., Z. Fooladvand, M. Salimpour, H. Ashourion, S. Nazari, and S. Abolmaali. "Screening Secondary Metabolites of Persian Gulf Sponges for Anticancer Agents." Journal of Biotechnology 150 (November 2010): 422–23. http://dx.doi.org/10.1016/j.jbiotec.2010.09.582.

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19

Saleh, Kamel, Tahani Albinhassan, Serage Elbehairi, et al. "Cell Cycle Arrest in Different Cancer Cell Lines (Liver, Breast, and Colon) Induces Apoptosis under the Influence of the Chemical Content of Aeluropus lagopoides Leaf Extracts." Molecules 24, no. 3 (2019): 507. http://dx.doi.org/10.3390/molecules24030507.

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Natural products, especially secondary metabolites produced by plants under stressed conditions, are shown to have different pharmacological impacts from one to another. Aeluropus lagopoides is one of the common halophyte plants that survive under stressed conditions, and has been used for healing wounds and as a painkiller. The bioactivity and the chemical composition of this plant have been poorly investigated. Consequently, the chemical components of A. lagopoides leaves were extracted using hexane (nonpolar), ethyl acetate (semi-polar), and n-butanol (polar) to extract the most extensive v
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20

Arafah, Andi Nur Samsi, and Rusmidin. "Review : Metabolit Sekunder pada Algae." BIOMA: Jurnal Biologi dan Pembelajarannya 3, no. 1 (2021): 30–35. http://dx.doi.org/10.31605/bioma.v3i1.999.

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All organisms have the ability to defend their lives from environmental threats. this can be seen from the secondary metabolites it contains. Secondary metabolites are compounds produced by organisms. Secondary metabolites are also found in marine life. Algae is a biota that is often explored to obtain secondary metabolites and is a major component in modern pharmacy. The potential of algae includes antiviral, antioxidant, antibacterial, neuromodulatory, antifungal, deworming, anti-inflammatory, anticancer, and others. One of the secondary metabolites produced by Phaeophyceae or brown algae is
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21

Khumalo, Makhosazana Jabulile, Nomfundo Nzuza, Tiara Padayachee, et al. "Comprehensive Analyses of Cytochrome P450 Monooxygenases and Secondary Metabolite Biosynthetic Gene Clusters in Cyanobacteria." International Journal of Molecular Sciences 21, no. 2 (2020): 656. http://dx.doi.org/10.3390/ijms21020656.

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The prokaryotic phylum Cyanobacteria are some of the oldest known photosynthetic organisms responsible for the oxygenation of the earth. Cyanobacterial species have been recognised as a prosperous source of bioactive secondary metabolites with antibacterial, antiviral, antifungal and/or anticancer activities. Cytochrome P450 monooxygenases (CYPs/P450s) contribute to the production and diversity of various secondary metabolites. To better understand the metabolic potential of cyanobacterial species, we have carried out comprehensive analyses of P450s, predicted secondary metabolite biosynthetic
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22

Math, Halaswamy Hire, Sreenivasa Nayaka, Muthuraj Rudrappa, et al. "Isolation, Characterization of Pyraclostrobin Derived from Soil Actinomycete Streptomyces sp. HSN-01 and Its Antimicrobial and Anticancer Activity." Antibiotics 12, no. 7 (2023): 1211. http://dx.doi.org/10.3390/antibiotics12071211.

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The present study demonstrated the isolation, characterization, and antimicrobial and anticancer activity of active metabolite produced from mining-soil-derived actinomycetes. Among the 21 actinomycete isolates, the isolate HSN-01 exhibited significant antimicrobial activity in primary screening and was identified as Streptomyces sp. through 16S rRNA gene sequencing. The active metabolite was separated, purified, and confirmed through UV–Vis spectroscopy, FTIR, HR-ESI-MS, and NMR analysis and identified as pyraclostrobin. Further, the active metabolite pyraclostrobin was tested for antimicrobi
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23

Pascayantri, Asniar, Mini Bekti Ningsih, Baru Sadarun, et al. "IN VITRO CYTOTOXICITY ASSAY OF Petrosia sp. ETHANOL EXTRACT BY USING MTT METHOD OF T47D BREAST CANCER CELL LINE." Jurnal Farmasi Sains dan Praktis 7, no. 3 (2022): 405–11. http://dx.doi.org/10.31603/pharmacy.v7i3.6128.

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Breast cancer is increasing as the constraints of side effects, drug-resistant, and high medical costs. Indonesia has a variety of marine biotas that can be explored. The sponge is one of the marines biotas that had potential candidates for anticancer compounds. The secondary metabolites of sponge such as steroids, alkaloids, polyketides, terpenoids, and polyacetylenes have pharmacology effects as anti-inflammation, antineoplastic and cytotoxic activity. The study is aimed to determine the secondary metabolite of Petrosian sp. ethanol extract and the cytotoxic activity at the T47D cell line of
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Veríssimo, Ana C. S., Mário Pacheco, Artur M. S. Silva, and Diana C. G. A. Pinto. "Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications." Molecules 26, no. 14 (2021): 4292. http://dx.doi.org/10.3390/molecules26144292.

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The development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has proved to be a huge source of bioactive compounds, making the discovery and study of these compounds a growing area. In the last few years, several compounds of marine origin, which include algae, corals, and sea urchins, have been isolated, studied, and demonstrated to possess anticancer properties.
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de Araújo, Rodrigo Santos Aquino, Edeildo Ferreira da Silva-Junior, Thiago Mendonça de Aquino, et al. "Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents." Current Topics in Medicinal Chemistry 20, no. 19 (2020): 1677–703. http://dx.doi.org/10.2174/1568026620666200607191838.

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: Computer-Aided Drug Design (CADD) techniques have garnered a great deal of attention in academia and industry because of their great versatility, low costs, possibilities of cost reduction in in vitro screening and in the development of synthetic steps; these techniques are compared with highthroughput screening, in particular for candidate drugs. The secondary metabolism of plants and other organisms provide substantial amounts of new chemical structures, many of which have numerous biological and pharmacological properties for virtually every existing disease, including cancer. In oncology
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26

Graça, V. C., Ricardo C. Calhelha, Fernando M. Nunes, Jérôme Berthet, Isabel C. F. R. Ferreira, and P. F. Santos. "Isolation of secondary metabolites from Geranium molle L. with anticancer potential." Industrial Crops and Products 142 (December 2019): 111859. http://dx.doi.org/10.1016/j.indcrop.2019.111859.

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27

Kouipou Toghueo, Rufin Marie, and Fabrice Fekam Boyom. "Endophytic Fungi from Terminalia Species: A Comprehensive Review." Journal of Fungi 5, no. 2 (2019): 43. http://dx.doi.org/10.3390/jof5020043.

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Endophytic fungi have proven their usefulness for drug discovery, as suggested by the structural complexity and chemical diversity of their secondary metabolites. The diversity and biological activities of endophytic fungi from the Terminalia species have been reported. Therefore, we set out to discuss the influence of seasons, locations, and even the plant species on the diversity of endophytic fungi, as well as their biological activities and secondary metabolites isolated from potent strains. Our investigation reveals that among the 200–250 Terminalia species reported, only thirteen species
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Yasmin, Rafida, Wulan Usfi Mafiroh, Anggiresti Kinasih, Aulia Noor Ramadhani, Rachmi Putri, and Endang Semiarti. "Potential of Orchids Secondary Metabolites as Anti-Cancer and Antimicrobial Based on Prediction of Phytochemical Activity with Online PASS-Software." Journal of Agromedicine and Medical Sciences 8, no. 1 (2022): 25. http://dx.doi.org/10.19184/ams.v8i1.26848.

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Abstract
 Orchidology is part of the branch of botany, it deals with a large family of monocotyledonous plants, Orchidaceae. Orchids have been used as traditional herbal medicines in Indonesia which are believed to be antimicrobial and anti-cancer. Orchids are able to produce secondary metabolites as their protective agent due to the extreme environment. Orchids have great diversity and potential to be the object of research, not only in experimental studies but also in a computational studies like in silico. Nowadays, molecular or metabolite data are available on the official-standard we
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29

Mbaoji, Florence Nwakaego, Justus Amuche Nweze, Liyan Yang, et al. "Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review." Molecules 26, no. 19 (2021): 5769. http://dx.doi.org/10.3390/molecules26195769.

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Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for
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Malacrida, Alessio, Valeria Cavalloro, Emanuela Martino, et al. "Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa—Part 2." Molecules 26, no. 21 (2021): 6596. http://dx.doi.org/10.3390/molecules26216596.

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Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the Hibiscus sabdariffa hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: Hib-ester and Hib-carbaldehyde. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and
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31

Kamble, Geetanjali R., Babu K. Gireesh, Shivaprakash V. Hiremath, and Murigendra B. Hiremath. "In vitro antimicrobial and anti-proliferative activity of crude methanolic extract of pigment from Streptomycetes spp. on HT-1080 fibro sarcoma cell line." Research Journal of Biotechnology 17, no. 5 (2022): 64–69. http://dx.doi.org/10.25303/1705rjbt64069.

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The ability to produce secondary metabolites like antibiotics is the characteristic feature of Streptomyces. Besides antibiotics, they are also seen to produce other bioactive compounds of economic importance like pigments which are potentially used in industries with remarkably appealing results. Under this backdrop, extraction of such priceless molecule from microbial source was the aim of this work. Actinomycetes strain isolated from water sample was identified as Streptomycetes with conventional and molecular approach. The metabolite exhibited antibacterial, antioxidant and anticancer acti
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Kowalczyk, Tomasz, Joanna Wieczfinska, Ewa Skała, Tomasz Śliwiński, and Przemysław Sitarek. "Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from Plant in Vitro Cultures." Plants 9, no. 2 (2020): 132. http://dx.doi.org/10.3390/plants9020132.

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The plant kingdom abounds in countless species with potential medical uses. Many of them contain valuable secondary metabolites belonging to different classes and demonstrating anticancer, anti-inflammatory, antioxidant, antimicrobial or antidiabetic properties. Many of these metabolites, e.g., paclitaxel, vinblastine, betulinic acid, chlorogenic acid or ferrulic acid, have potential applications in medicine. Additionally, these compounds have many therapeutic and health-promoting properties. The growing demand for these plant secondary metabolites forces the use of new green biotechnology too
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Mir, Manzoor A., Syed S. Hamdani, Bashir A. Sheikh, and Umar Mehraj. "Recent Advances in Metabolites from Medicinal Plants in Cancer Prevention and Treatment." Current Immunology Reviews 15, no. 2 (2019): 185–201. http://dx.doi.org/10.2174/1573395515666191102094330.

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Cancer is the second leading cause of death and morbidity in the world among noncommunicable diseases after cardiovascular ailments. With the advancement in science and research, a number of therapies have been developed to treat cancer, including chemotherapy, radiotherapy and immunotherapy. Chemo and radiotherapy have been in use since the last two decades, however these are not devoid of their own intrinsic problems, such as myelotoxicity, cardiotoxicity, nephrotoxicity, neurotoxicity and immunosuppression. Hence, there is an urgent need to develop alternative methods for the treatment of c
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Chakraborty, Prasanta. "Gene Clusters from Plants to Microbes: Their Role in Specialized Metabolism and Drug Development." International Journal of Pharmacognosy & Chinese Medicine 2, no. 5 (2018): 1–2. http://dx.doi.org/10.23880/ipcm-16000149.

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35

Nurul Komala, Syarifah Iis Aisyah, and Waras Nurcholis. "Induced Mutation by Colchicine in Java Cardamom (Amomum compactum Soland. ex Maton) Generation MV1." Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 50, no. 2 (2022): 233–40. http://dx.doi.org/10.24831/jai.v50i2.40246.

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Java cardamom is an important commodity that produces secondary metabolite. Secondary metabolites of Java cardamom are utilized as an anti-inflammatory, antibacterial and anticancer. Improve secondary metabolite through colchicine-induced mutation are necessary to get polyploid. It has been reported that polyploid produces higher secondary metabolites. This research aimed to describe Java cardamom’s phenotypes resulting from colchicine treatment and identify ploidy levels through flow cytometry. This research was conducted from July 2021 to January 2022 at the Leuwikopo Experimental Field, Fac
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36

Shati, Ali A., Mohammed A. Alkahtani, Mohamed Y. Alfaifi, et al. "Secondary Metabolites of Saussurea costus Leaf Extract Induce Apoptosis in Breast, Liver, and Colon Cancer Cells by Caspase-3-Dependent Intrinsic Pathway." BioMed Research International 2020 (July 13, 2020): 1–11. http://dx.doi.org/10.1155/2020/1608942.

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Background. Apoptosis, a major form of programmed cell death, plays a vital role in regulating tissue development and maintenance of homeostasis in eukaryotes. Apoptosis can occur via a death receptor-dependent extrinsic or a mitochondrial-dependent intrinsic pathway and can be induced by various chemotherapeutic agents. In this study, the anticancer activity of Saussurea costus and its mode of intervention in human cancer cells of breast, colon, and liver were investigated. Results. In this study, the bioactives of S. costus leaves were extensively extracted in five solvents of different pola
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Werdyani, Sista, Nastiti Wijayanti, Annisa Fitria, and Sari Rahmawati. "CYTOTOXIC EFFECTS OF ETHYL ACETATE FRACTIONS FROM SECONDARY METABOLITES OF STREPTOMYCES SP. GMY01 ON HUMAN BREAST CANCER MCF7 CELL LINES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 14 (2017): 5. http://dx.doi.org/10.22159/ajpcr.2017v10s3.21351.

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Objective: This research aimed to fractionate the ethyl acetate extract from secondary metabolites of Streptomyces sp. GMY01 and to identify which fraction contains cytotoxic active compounds against human breast cancer MCF7 cell lines.Methods: Secondary metabolites were obtained from fermentation of Streptomyces Sp. GMY01 for 15 d. The supernatant containing these secondary metabolites was extracted through partition using ethyl acetate as the solvent. Fractionation of the ethyl acetate extract was conducted via column chromatography using silica gel as the solid phase while the gradient mobi
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Hartiadi, Leonny Yulita, Immaculata Titis Winiati, Samirah -, and Cristina Gomez. "Cytotoxicity Evaluation of Bacteria Extract Isolated from Indonesia Sheep Manures and Fungal Fruiting Body." Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online) 2, no. 1 (2020): 1–7. http://dx.doi.org/10.54250/ijls.v2i1.31.

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Introduction: Cancer is one of the leading cause of death worldwide. Chemotherapy remains the most widely used approach to treat cancer. However, due to the lack of specificity, drug resistance, and undesirable side effects, the discovery of novel anticancer drugs is still a priority in cancer research. Bacteria are one of the major contributors for anticancer compounds as bacteria are able to produce secondary metabolites which may have cytotoxic activity. Method: A literature study was conducted to identify the isolates in i3L-USAID bacteria database that were potential candidates for novel
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J., Mohan, Mohan N., Narendra Babu Shakya, Amit Pandey, and Raghvendra Chauhan. "A review on secondary metabolites, pharmacological status and phytoremediation to treat water hyacinth." Annals of Plant Sciences 7, no. 4 (2018): 2170. http://dx.doi.org/10.21746/aps.2018.7.4.1.

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Eichhornia crassipes (Mart.) Solms (Water hyacinth), an oceanic lasting herb display All around the world, need a heap from claiming metabolites. Extracts, and additionally immaculate exacerbates disconnected starting with this plant, have been showed with have pharmacological exercises for example, such that phenolic Compounds, Alkaloids, Terpenoids, Sterols, Glycosides, Flavonoid, Resins, Anthroquinone, Saponins, Tannins. Eichhornia crassipes (water hyacinth) could a chance to be usefully utilized will extricate supplements from sewage. It is likewise demonstrated advantageous in treating ef
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Wang, Zhenxin, Xilong Feng, Chengwei Liu, Jinming Gao, and Jianzhao Qi. "Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus." Antibiotics 11, no. 8 (2022): 1097. http://dx.doi.org/10.3390/antibiotics11081097.

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Inonotus hispidus mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from I. hispidus and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from I. hispi
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Conte, Mariarosaria, Elisabetta Fontana, Angela Nebbioso, and Lucia Altucci. "Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy." Marine Drugs 19, no. 1 (2020): 15. http://dx.doi.org/10.3390/md19010015.

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Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both abiotic and biotic components of the ecosystem. This extremely complex and dynamic process often results in different forms of competition to ensure the maintenance of an ecological niche suitable for survival. A high percentage of marine species have evolved to synthesize biologically active molecules, termed secondary metabolites, as a defense mechanism against the external environment. These natural products and their derivatives may play modulatory roles in the epigenome and in disease-associated epigenetic
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Bhat, N. B., A. Joseph, R. C. Hariharapura, et al. "In-vitro ANTICANCER ACTIVITY OF LICHEN Heterodermia boryi AND ITS SECONDARY METABOLITES." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2885–92. http://dx.doi.org/10.31788/rjc.2022.1547025.

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Lichens are symbiotic organisms that have been traditionally used for treating different kinds of ailments. Heterodermia boryi is a common foliose lichen found growing luxuriantly in the Western Ghats. It is clear from the literature survey that there are no reports on the isolation and biological activity of lichen substances from Heterodermia boryi, we thought of exploring the anticancer activity of its crude extract and isolated compounds. Fractionation of crude methanolic extract of Heterodermia boryi by column chromatography led to the isolation of three pure compounds. The crude methanol
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Indriyani, Nastiti Nur, Jamaludin Al Anshori, Nandang Permadi, Sarifah Nurjanah, and Euis Julaeha. "Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development." Foods 12, no. 10 (2023): 2036. http://dx.doi.org/10.3390/foods12102036.

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Citrus aurantifolia is part of the Rutaceae family and belongs to the genus Citrus. It is widely used in food, the chemical industry, and pharmaceuticals because it has a unique flavor and odor. It is nutrient-rich and is beneficial as an antibacterial, anticancer, antioxidant, anti-inflammatory, and insecticide. Secondary metabolites present in C. aurantifolia are what give rise to biological action. Flavonoids, terpenoids, phenolics, limonoids, alkaloids, and essential oils are among the secondary metabolites/phytochemicals discovered in C. aurantifolia. Every portion of the plant’s C. auran
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Azhari, Arif, Muhammad Yogi Saputra, Muhammad Raffi Zakaria, et al. "Potential Antioxidant Constituent from Leaf of Rhizophora apiculata an Typical Mangrove at Lempasing, South Lampung Coast." Stannum : Jurnal Sains dan Terapan Kimia 4, no. 2 (2022): 60–67. http://dx.doi.org/10.33019/jstk.v4i2.3631.

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The mangrove woodland is a distinct bush or brine habitat characterized by a coastal sedimentation environment in which fine sediment (often rich in organic matter) accumulates in areas protected from high energy waves. Mangrove forests thrive on the coasts of tropical and subtropical regions, including Indonesia. Mangrove forest is a complex ecosystem that has a high diversity of plants, microorganisms, and animals. One of them is the Oil Mangrove (R. apiculata) which grows well on the coast of Lampung. This plant is hard, rich in tannins, and dense, mainly used to make charcoal and firewood.
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Poulsen-Silva, Erick, Felipe Gordillo-Fuenzalida, Cristian Atala, Adrián A. Moreno, and María Carolina Otero. "Bioactive Lichen Secondary Metabolites and Their Presence in Species from Chile." Metabolites 13, no. 7 (2023): 805. http://dx.doi.org/10.3390/metabo13070805.

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Lichens are symbiotic organisms composed of at least one fungal and one algal species. They are found in different environments around the world, even in the poles and deserts. Some species can withstand extreme abiotic conditions, including radiation and the vacuum of space. Their chemistry is mainly due to the fungal metabolism and the production of several secondary metabolites with biological activity, which have been isolated due to an increasing interest from the pharmaceutical community. However, beyond the experimental data, little is known about their mechanisms of action and the pote
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Balabhaskar, R., and K. Vijayalakshmi. "Anticancer activity of secondary metabolites from Bauhinia tomentosa Linn. leaf – An in silico approach." Biomedicine 41, no. 3 (2021): 552–64. http://dx.doi.org/10.51248/.v41i3.1193.

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Introduction and Aim: Plants and plant derived products are used for human healthcare since the dawn of human civilization. About 80% of modern drugs are from natural origin. Many dreadful diseases like cancer are treated using drugs of natural origin. In the present study, a medicinal plant B. tomentosa Linn. leaves were investigated for its anticancer activity using A549 (Human Adenocarcinomic Alveolar Basal Epithelial Cells) cell lines. The active components were identified using GC-MS (Gas Chromatography- Mass Spectrophotometry) analysis. The aim of the present study was to identify potent
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Tesfaye, Solomon, Kaleab Asres, Ermias Lulekal, et al. "Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective." Molecules 25, no. 17 (2020): 4032. http://dx.doi.org/10.3390/molecules25174032.

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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiprol
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Mondal, Arijit, Sankhadip Bose, Sabyasachi Banerjee, et al. "Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs." Marine Drugs 18, no. 9 (2020): 476. http://dx.doi.org/10.3390/md18090476.

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Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy.
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Rehan, Medhat, Abdellatif Gueddou, Abdulaziz Alharbi, and Imen Ben Abdelmalek. "In Silico Prediction of Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Streptomyces thinghirensis HM3 Isolated from Arid Soil." Fermentation 9, no. 1 (2023): 65. http://dx.doi.org/10.3390/fermentation9010065.

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Natural products produced by microorganisms are considered an important resource of bioactive secondary metabolites, such as anticancer, antifungal, antibiotic, and immunosuppressive molecules. Streptomyces are the richest source of bioactive natural products via possessing a wide number of secondary metabolite biosynthetic gene clusters (SM-BGCs). Based on rapid development in sequencing technologies with advances in genome mining, exploring the newly isolated Streptomyces species for possible new secondary metabolites is mandatory to find novel natural products. The isolated Streptomyces thi
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Vallavan, Vimalah, Getha Krishnasamy, Noraziah Mohamad Zin, and Mazlyzam Abdul Latif. "A Review on Antistaphylococcal Secondary Metabolites from Basidiomycetes." Molecules 25, no. 24 (2020): 5848. http://dx.doi.org/10.3390/molecules25245848.

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Fungi are a rich source of secondary metabolites with several pharmacological activities such as antifungal, antioxidant, antibacterial and anticancer to name a few. Due to the large number of diverse structured chemical compounds they produce, fungi from the phyla Ascomycota, Basidiomycota and Muccoromycota have been intensively studied for isolation of bioactive compounds. Basidiomycetes-derived secondary metabolites are known as a promising source of antibacterial compounds with activity against Gram-positive bacteria. The continued emergence of antimicrobial resistance (AMR) poses a major
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