Log in

Relevant bibliographies by topics / Anticancer treatment / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Anticancer treatment.

Dissertations / Theses on the topic 'Anticancer treatment'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Anticancer treatment.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

DREUSSI, EVA. "Pharmacogenomics of miRNA for personalized anticancer treatment." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908099.

Full text

Abstract:

Pharmacogenetics (PGx) aims at the definition of predictive and prognostic genetic biomarkers that can help clinicians in treatment tailoring. In this thesis, we explored two emerging topics in PGx: SNPs affecting the activity and maturation of a class of non coding RNAs, microRNAs (miRNAs), and immunogenetics. Genetic analyses were performed by a medium throughput technology, Veracode technology (Illumina). The clinical model of this study is represented by the locally advanced rectal cancer (LARC). Specifically, the main two aims of this study were: 1. the identification of predictive bioma

APA, Harvard, Vancouver, ISO, and other styles

2

Magri, Neal Francis. "Modified taxols as anticancer agents." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/53892.

Full text

Abstract:

Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, succinyl, trichloroethyloxycarbonyl or carbonate linked dibenzylidene protected glucosyl groups. The C-7 position was selectively epimerized under free radical conditions and a 2'-epiacetyltaxol was produced via base catalysed epimerization. The C-2' amide became nucleophilic in the presence of base an

APA, Harvard, Vancouver, ISO, and other styles

3

Coldman, Andrew James. "The development of resistance to anticancer agents." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26975.

Full text

Abstract:

The mechanism of resistance of tumor cells to chemotherapeutic agents is explored using probabilistic methods where it is assumed that resistant cells arise spontaneously with a defined frequency. The resistance process is embedded in a discrete time Markov branching process which models the growth of the tumor and contains three seperate cell types: stem, transitional and end cells. Using the asymptotic properties of such models it is shown that the proportion of each type of cell converge to constants almost surely. It is shown that the parameters relating to stem cell behaviour determine th

APA, Harvard, Vancouver, ISO, and other styles

4

Fumagalli, G. "DRUG-CONJUGATES FOR SELF-ASSEMBLED NANOPARTICLES IN ANTICANCER TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/542496.

Full text

Abstract:

This dissertation is an overview on the functionalization of known anticancer compounds in order to form different drug-conjugates able to self-assemble in water to form nanoparticles. This approach is useful to improve the drug delivery properties and pharmacokinetic profile of anticancer drugs. All the described conjugates, except for the ones illustrated in chapter 5, have the same general structure: the anticancer drug is connected to the self-assembly inducer trough a linker. Chapter 1 regards a general introduction about nanomedicine, the advantages of the use of nanotechnology-based s

APA, Harvard, Vancouver, ISO, and other styles

5

Zhang, Wen. "Identification of novel pyruvate dehydrogenase kinase 1 (PDK1) inhibitors for anticancer therapeutics." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953604.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Cadorette, Veronica R. "Chemical investigation of Dicranum fulvum for anticancer activity." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44706.

Full text

Abstract:

<p>Biological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both <u>in vitro</u> and <u>in vivo</u> bioassays. This plant was thus selected for extraction and fractionation, monitored by i<u>in vitro</u> bioassays.</p> <p>Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanostâ 23â eneâ 3,25â diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotr

APA, Harvard, Vancouver, ISO, and other styles

7

Soler, Vives Marta. "Peptide conjugates containing chlorambucil or tetradentate aminopyridine ligands for anticancer treatment." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/285974.

Full text

Abstract:

Nowadays, the search for new drugs against cancer is one of the major goals to improve the quality of life of patients. The development of more selective treatments against cancer cells may lead to a significant reduction of the side-effects, being one of the most important topics in current research. In this regard, cell-penetrating peptides (CPPs) have been described to efficiently transport therapeutic molecules across the cell membrane. Furthermore, some metal complexes based on platinum (cisplatin and derivatives) are used in current chemotherapy. Despite their efficacy, these drugs displ

APA, Harvard, Vancouver, ISO, and other styles

8

Cozzi, Sarah-Jane. "Molecular targets of anticancer PKC activators in the treatment of melanoma /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19185.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Lewis, Andrew Martin. "The synthesis and biological evaluation of a novel anticancer small molecule." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Cassim, Layla. "Melatonin and anticancer therapy interactions with 5-Fluorouracil." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003224.

Full text

Abstract:

On the basis of clinical studies, some researchers have advocated that the neurohormone and antioxidant melatonin, shown to possess intrinsic anticancer properties, be used as co-therapy in cancer patients being treated with the antineoplastic agent 5-fluorouracil, as increased patient survival times and enhanced quality of life have been observed. The focus of this research was thus to investigate the mechanisms of this seemingly beneficial drug interaction between 5-fluorouracil and melatonin. Metabolism studies were undertaken, in which it was established that there is no hepatic metabolic

APA, Harvard, Vancouver, ISO, and other styles

11

Chan, Hoi-ching, and 陳凱靜. "Heat shock protein 90 inhibitor 17-AAG potentiates anticancer activityof bortezomib in NK cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Žáková, Eliška. "Nanočástice na bázi ruthenia a testování jejich protinádorové aktivity." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316830.

Full text

Abstract:

Neoplastic diseases hold the second place of the most common causes of death worldwide. Available treatments include various combinations of surgery, chemotherapy, radiation, hormone therapy, immune therapy and targeted therapy. The emphasis is currently laid on nanomedicine, where new nanosized complexes are developed and applied for the targeted treatment and chemotherapy. The aim is to significantly improve the anticancer effect and decrease the damage to organism. In this thesis, ruthenium nanoparticles with a size of 12–14 nm were synthesized and their surface modified with polyvinylpyrro

APA, Harvard, Vancouver, ISO, and other styles

13

Brazzale, Chiara. "Gold nanoparticle surface tuning for multimodal treatment of cancer." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424441.

Full text

Abstract:

In the last decades colloidal decorated gold nanoparticles (GNPs) have been studied as platform for drug and gene delivery, for diagnostic and other biomedical applications. These metal nanoparticles are intriguing because of their unique physico-chemical properties that can be exploited for multimodal and combined treatment of cancer. In the present thesis work gold nanoparticles were decorated with a targeting ligand (Folate-PEG) to combine an active and a passive targeting aiming to enhance the selective accumulation within the tumour site. Deep studies have been done to investigate the eff

APA, Harvard, Vancouver, ISO, and other styles

14

Booker, Victoria. "Investigating the occurrence and fate of anticancer drugs in sewage treatment works and the wider aquatic environment." Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/82556/.

Full text

Abstract:

The occurrence of pharmaceuticals in wastewater and the wider environment is of growing concern. This thesis focuses on anticancer drugs - a group of biologicallypotent and often recalcitrant set of chemicals whose fate and impact on the wider freshwater environment is poorly studied. The aims of this thesis were to prioritise a group of anticancer drugs for environmental monitoring programmes (from the many drugs in use), based on their consumption and fate during wastewater treatment; to undertake a national and regional survey of two commonly used anticancer drugs, cyclophosphamide (CP) and

APA, Harvard, Vancouver, ISO, and other styles

15

Serafin, Antonio Mendes. "Cell biological responses of prostatic tumour cell lines to irradiation and anticancer drugs." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53321.

Full text

Abstract:

Thesis (PhD)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: The "classic" prostate cell lines, DU145, PC-3 and LNCaP, have served as a valuable cell biological model for research into prostate cancer. However, their relevance may be limited because they derive from metastatic, and not from primary normal and tumour epithelium. The cell lines (1532T, 1535T, 1542T, 1542N and BPH-l) have been derived from primary benign and malignant human tumour prostate epithelium and may be more representative. Using these cell lines I have examined the role of basic cell damage responses (repair

APA, Harvard, Vancouver, ISO, and other styles

16

Freidberg, Ryno. "An investigation into the antimicrobial and anticancer activities of Geranium incanum, Artemisia afra and Artemisia absinthium." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1045.

Full text

Abstract:

It has been estimated that between 3000 and 4000 plant species are used for their medicinal properties throughout South Africa, with approximately 27 million South Africans making use of traditional medicines. Of this 27 million, 3 million South Africans rely on traditional medicine as their primary source of health care. Of the 250 000 to 500 000 known plant species, very few have been investigated for their pharmacological qualities, and compounds of significant medicinal value may still remain undiscovered in many plant species. The aims of this study included investigating the antimicrobia

APA, Harvard, Vancouver, ISO, and other styles

17

Holzapfel, Nina Pauline. "Investigation of the potential anticancer effects of lycopene in tissue engineered in vitro and in vivo models." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/107571/1/Nina%20Pauline_Holzapfel_Thesis.pdf.

Full text

Abstract:

This project is a step forward in understanding the mode of action of phytochemicals in the prevention and therapy of cancer by using tissue engineered in vitro and in vivo models. In this thesis, the natural compound lycopene, primarily found in tomatoes and tomato based products, was tested as a treatment option especially for ovarian cancer patients. The study revealed the distinct potential of lycopene to prevent the onset of ovarian cancer and its ability to reduce tumor and metastatic load in an already established disease status, as tested in an intraperitoneal humanized animal model.

APA, Harvard, Vancouver, ISO, and other styles

18

Golovko, Olga. "The screening for novel proteasome inhibitors as a treatment of cancer using IncuCyte FLR and fluorometric microculture cytotoxicity assay." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160700.

Full text

Abstract:

The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation. Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment. The study aimed to test vari

APA, Harvard, Vancouver, ISO, and other styles

19

Wang, Yue. "Exploration of the novel anticancer mechanisms of medicinal compounds involving calpain and S100A4 in the treatment of colon cancer." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/270.

Full text

Abstract:

In summary, this thesis has explored the anti-cancer mechanisms of novel medicinal compounds via targeting calpains or S100A4 in the treatment of colon cancer, which could facilitate future establishment of effective medicinal compounds in the treatment of metastatic colon cancers with known molecular targets.;The incidence of colon cancer in Hong Kong and worldwide is on a rising trend, while its metastatic development is the leading cause of cancer-related deaths. Understanding the molecular mechanisms of how tumors progress and metastasize to secondary sites, at both biological and genetic

APA, Harvard, Vancouver, ISO, and other styles

20

Majmudar, Pooja M. "Investigating Molecular Targets of Phosphaplatins: A Class of Novel Non-DNA-Binding Platinum Anticancer Agents in the Treatment of Ovarian Cancer." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1300373466.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Zhang, Zhu. "Exploration of the anticancer mechanisms of novel chemotherapeutic adjuvants involving autophagy and immune system reprogramming in the treatment of pancreatic cancer." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/755.

Full text

Abstract:

Pancreatic cancer is known to be one of the most life-threatening cancers characterized by aggressive local invasion and distant metastasis. The high basal level of autophagy in pancreatic cancer may be responsible for the low chemotherapeutic drug response rate and poor disease prognosis. However, the clinical application of autophagy inhibitors was unsatisfactory due to their toxicity and minimal single-agent anticancer efficacy. Hence, oncologists begin to consider the tumor microenvironment when exploring new drug targets. In the present study, the anti-tumorigenic mechanisms of two major

APA, Harvard, Vancouver, ISO, and other styles

22

Pardella, Elisa. "Therapy-induced stromal senescence promotes prostate cancer progression and aggressiveness." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128061.

Full text

Abstract:

Although chemotherapy still represents the gold-standard treatment option for cancer cure, it often results in several long-term negative side effects, including cancer relapse and acquired resistance to the therapy. Docetaxel is the preferred anticancer drug for several tumor types, including metastatic castrate-resistant prostate cancer. However, it exhibits only modest efficacy and many patients who received Docetaxel treatment experience tumor progression and chemotherapy insensitivity. Therefore, identifying the molecular mechanisms that associate anticancer therapy with its negative byst

APA, Harvard, Vancouver, ISO, and other styles

23

Yaacoub, Katherine. "c-FLIP as a potent anticancer target : Enhancement of cancer cell apoptosis by compounds identified through virtual screening." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B011/document.

Full text

Abstract:

FLIP (FLICE inhibitory protein) est une protéine anti-apoptotique qui a des identités de séquence partagées avec la protéine pro-apoptotique caspase-8. FLIP se trouve en compétence avec caspase-8 pour se fixer sur la protéine adaptatrice FADD, ce qui empêche l’activation de caspase-8 bloquant ainsi l'apoptose. Lors du développement des molécules interférant avec des protéines anti-apoptotiques, la recherche d'inhibiteurs de la protéine FLIP qui est surexprimée dans un très grand nombre de cancers, a échoué. Cela s'explique en partie par le fait que peu d'information structurelle de FLIP est ac

APA, Harvard, Vancouver, ISO, and other styles

24

Choi, Stephen Yiu Chuen. "Targeting MCT4 for treatment of advanced prostate cancers : inhibiting cell proliferation and enhancing anticancer immunity through suppressing lactic acid secretion and elevated glycolysis." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63874.

Full text

Abstract:

Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in North American males and a leading cause of cancer deaths. The lack of effective treatment options for advanced PCa such as AR-positive castration-resistant PCa (CRPC-AD) and the highly aggressive AR-negative CRPC, e.g. neuroendocrine PCa (CRPC-NE) presents a critical, unmet need for the development of novel therapeutics. Altered metabolism in the form of elevated aerobic glycolysis is a common cancer characteristic. Here we propose a novel conceptual understanding for the central, functional role of excessive cancer-

APA, Harvard, Vancouver, ISO, and other styles

25

Marwah, Mandeep Kaur. "Development of a novel deformable liposomal formulation for the dermal drug delivery of anticancer agents in the treatment of non-melanoma skin cancers." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37493/.

Full text

Abstract:

The incidence of skin cancer is increasing and conventional treatments such as surgery are not suitable for all patients. This study aimed to develop an elastic liposomal gel to be applied directly to the tumour for the controlled release of anti-cancer agents to the dermal layer. The proposed anti-cancer flavonoids EGCG and naringenin as well as the novel potent cytotoxic agent MTL-004 were loaded into the bilayer of liposomes. Furthermore, aqueous gels HEC and HPMC were investigated as carriers for the liposomes to be applied topically. Liposomes loaded with either Tween 80, Tween 20 or sodi

APA, Harvard, Vancouver, ISO, and other styles

26

Shaw, Yeng-Jeng. "Small molecule-based drug design of anticancer agents that target protein kinase B / AKT, Bcl-xL and DNA methyltransferases for the treatment of prostate cancer." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1128693982.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Wolf, Siglinde Guillermina Morelia [Verfasser], Tad [Akademischer Betreuer] Holak, Michael [Akademischer Betreuer] Groll, and Robert [Akademischer Betreuer] Huber. "Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment / Siglinde Guillermina Morelia Wolf. Gutachter: Michael Groll ; Robert Huber. Betreuer: Tad Holak." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031550623/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Coluccelli, Sara <1992&gt. "Chemo-physical and biological mechanisms behind the anticancer activity of plasma activated Ringer's Lactate solution for the treatment of peritoneal carcinosis from primitive epithelial ovarian/tubular tumor." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10443/1/coluccelli_sara_tesi.pdf.

Full text

Abstract:

Cancer research and development of targeting agents in this field is based on robust studies using preclinical models. The failure rate of standardized treatment approaches for several solid tumors has led to the urgent need to fine-tune more sophisticated and faithful preclinical models able to recapitulate the features of in vivo human tumors, with the final aim to shed light on new potential therapeutic targets. Epithelial Ovarian Cancer (EOC) serous histotype (HGSOC) is one of the most lethal diseases in women due to its high aggressiveness (75% of patients diagnosed at FIGO III-IV state)

APA, Harvard, Vancouver, ISO, and other styles

29

El, Banna Nadine. "La génération du stress oxydant comme stratégie thérapeutique anticancéreuse : Investigation des mécanismes d’action de la vitamine C, de l’auranofin et de leur combinaison." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS232.

Full text

Abstract:

L’équilibre rédox entre les niveaux des espèces réactives de l’oxygène et de l’azote (ROS, RNS) et les espèces antioxydantes cellulaires est déterminant pour le fonctionnement normal de la cellule et sa viabilité. Le déséquilibre redox ou « stress oxydant » peut altérer les voies de signalisation cellulaires et générer des dommages sur les protéines, les lipides et l’ADN des cellules. Il est ainsi associé à de nombreuses pathologies, notamment les cancers. Les cellules cancéreuses présentent une dérégulation redox importante et un stress oxydant basal intrinsèque plus élevé par rapport aux cel

APA, Harvard, Vancouver, ISO, and other styles

30

Sargeant, Aaron Matthew. "Preclinical Efficacy and Safety Evaluation of Novel Small-Molecule Targeted Agents for the Prevention and Treatment of Prostate Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243948876.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Calvet, Christophe. "Immunological aspects of anticancer electroporation-based treatments." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114816.

Full text

Abstract:

L'électrochimiothérapie est un traitement anticancéreux utilisé en routine en Europe dans près de 130 centres de traitement du cancer. Le taux de réponse objective atteint 85 % pour le traitment de tumeurs cutanées et sous-cutanées et des études sont en cours afin d'appliquer ce traitement à des tumeurs profondes. Au cours de ce doctorat, les méchanismes sous-jacents à cette excellente efficacité antitumorale ont été étudiés. Dans un premier temps, l'objectif a été d'évaluer la capacité de l'électrochimiothérapie à induire la mort des cellules souches cancéreuses, considérées comme les racines

APA, Harvard, Vancouver, ISO, and other styles

32

Reinhardt, Camille. "Impact de la voie d’import mitochondrial contrôlée par le complexe AIF/CHCHD4 sur la survie des cellules cancéreuses et la réponse aux traitements anticancéreux." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS542.

Full text

Abstract:

Dans la majorité des cas, les mitochondries sont nécessaires à la tumorigenèse et à la réponse des cellules cancéreuses aux signaux générés par les facteurs micro-environnementaux (exemples : privation de nutriments, hypoxie) ou par les traitements anticancéreux (exemples : chimiothérapie, radiothérapie). Presque toutes les protéines mitochondriales sont codées par le génome nucléaire et importées dans l'organelle. Des machineries d'import ont donc évolué afin de répondre aux besoins d'import protéique. Dans ce contexte, la machinerie régulée par CHCHD4/Mia40 fonctionne dans l’espace intermemb

APA, Harvard, Vancouver, ISO, and other styles

33

Iurisci, Ida. "Targeting anticancer treatments on circadian cloks : experimental and clinical approaches." Paris 11, 2008. http://www.theses.fr/2008PA11T016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Grove, Jan. "An evaluation of the current practices followed by oncologists in private practice in Cape Town, South Africa, in the management of patients with advanced cancer which no longer responds to anticancer treatment and the identification of the needs associated with such management." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12646.

Full text

Abstract:

Includes abstract.~Includes bibliographical references.<br>Managing patients whose disease has become unresponsive to anticancer treatment confronts oncologists with major stressors which may range from the management of distressing physical symptoms to complex psychosocial issues. These sets of circumstances prompted the undertaking of this study: An evaluation of the current practices followed by oncologists in private practice in Cape Town, South Africa, in the management of patients with advanced cancer which no longer responds to anticancer treatment and the identification of the needs as

APA, Harvard, Vancouver, ISO, and other styles

35

Hei, Zhiliang. "Targeting acute myeloid leukemia through redox modulation by the drug combination of auranofin and vitamin C." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL082.

Full text

Abstract:

L'homéostasie des espèces réactives de l'oxygène (ROS) et des espèces réactives de l'azote (RNS), ainsi que la dynamique des processus redox, sont cruciaux pour réguler le destin cellulaire et maintenir une fonction cellulaire normale. Par rapport aux cellules normales, les cellules cancéreuses maintiennent généralement un état pro-oxydant persistant en raison de l'activation d'oncogènes, d'un métabolisme aberrant, de dysfonctionnements de la mitochondrie, et dans certains cas, de défauts des systèmes de défense antioxydants. Cet état pro-oxydant, ainsi que leur dépendance aux systèmes antioxy

APA, Harvard, Vancouver, ISO, and other styles

36

UYSAL, GÜNES. "Dendritiska nanogeler som platform för läkemedelsleverans." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-251007.

Full text

Abstract:

Utveckling av polymer baserade läkemedelsbärare i nanostorlek har blivit allt viktigare för att effektivisera behandling och diagnosering av olika sjukdomar, speciellt cancer. Flera läkemedel som används i kemoterapi har bristfälliga egenskaper som låg löslighet i vatten, oönskad nedbrytbara till dess inaktiva form, och distribution i stora volymer till oönskade organ p.g.a. dess icke-selektiva förmåga. Nanopartiklar är små partiklar med diameter 1-500 nm som genom passiv/aktiv transport kan passera olika biologiska barriärer och transportera läkemedel i optimala mängder till specifika celler.

APA, Harvard, Vancouver, ISO, and other styles

37

Avella, Vasquez Ana Catalina. "Substances polymériques extracellulaires dans les procédés de traitement des eaux usées." Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL029N/document.

Full text

Abstract:

L’objectif de ce travail est d’une part (i) étudier le comportement de la biomasse notamment la production d’EPS en présence des composés pharmaceutiques (un agent anticancéreux et cinq antibiotiques); et d’autre part, (ii) étudier les EPS dans le contexte de décantation des boues en présence d’agents fongiques et en situations réelles dans des stations d’épuration. L’étude en présence de l’agent anticancéreux a été réalisée dans des bioréacteurs à membranes. La présence de l’agent anticancéreux a induit l’augmentation de la production d’EPS agissant comme un mécanisme de protection microbienn

APA, Harvard, Vancouver, ISO, and other styles

38

Kotadia, Nayna. "A Study on the Protein Interaction with Different Platinum Compounds." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/8.

Full text

Abstract:

Since the discovery of anti-tumor activity of cisplatin in 1960, significant progress has been made in treating metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like methionine, histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of react

APA, Harvard, Vancouver, ISO, and other styles

39

Dhellemmes, Alice. "Impact de la voie d'administration des anticancéreux sur la qualité de vie des patients : rôles des processus transactionnels et bénéfices d'une éducation thérapeutique." Thesis, Toulouse 2, 2019. http://www.theses.fr/2019TOU20020.

Full text

Abstract:

La délocalisation de la chimiothérapie de l’hôpital vers le domicile et l’arrivée des anticancéreux oraux transforment radicalement le schéma thérapeutique des patients atteints de cancer. Ce dernier, inédit dans le domaine de l’oncologie, fait reposer l’efficacité du protocole sur la responsabilité entière du patient, de la délivrance du médicament à la gestion des effets secondaires. Cet éloignement de la sphère hospitalière et des soins de support amène les patients à gérer également seuls les conséquences psychologiques de la maladie. La première étude de cette thèse est transversale avec

APA, Harvard, Vancouver, ISO, and other styles

40

Sabatino, Maria Antonietta. "Combination treatments in in vitro and in vivo models between molecules reverting epigenetic gene silencing and DNA-interacting anticancer drugs." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502390.

Full text

Abstract:

Epigenetic transcriptional gene silencing plays a fundamental role in cancer development and has been considered as a target for cancer therapy in the last few years, mainly due to its reversibility by small molecules. Among the several methylated genes investigated, glutathione-S-transferase CGST) PI, a protein belonging to cellular detoxification systems, has been shown to be extensively promoter-methylated in prostate cancer. My study therefore describes a new therapeutic approach against prostate cancer, based on the combination of demethylating agents and brostallicin, a DNA minor groove

APA, Harvard, Vancouver, ISO, and other styles

41

Sturgeon, Christopher Michael. "G₂ DNA damage checkpoint : inhibitors and there potential for anticancer treatment." Thesis, 2006. http://hdl.handle.net/2429/18578.

Full text

Abstract:

In response to DNA damage, cell survival can be enhanced by activation of DNA repair mechanisms and of checkpoints that delay cell cycle progression to allow more time for DNA repair. G₂ checkpoint inhibitors can force cells arrested in G₂ phase by DNA damage to enter mitosis thereby enhancing the killing of cancer cells by DNA-damaging approaches. Checkpoint inhibitors represent a promising class of therapeutic agents in the treatment of cancer. The goals of my research were to (i) characterize novel checkpoint inhibitors in terms of their therapeutic potential and, if possible, mode of actio

APA, Harvard, Vancouver, ISO, and other styles

42

Naicker, Leeann. "Anticancer activity of ceratotheca triloba." Thesis, 2016. http://hdl.handle.net/10321/1726.

Full text

Abstract:

Submitted in complete fulfillment for the Degree of Doctorate of Philosophy in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.<br>Plants have provided a source of medicine from the beginning of human history and are the core of modern medicine. Moreover, plant based drug discovery has led to the development of various anticancer drugs (such as vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). The use of botanical, phytochemical, biological and molecular techniques have facilitated the discovery of anthraquinones from Ceratothe

APA, Harvard, Vancouver, ISO, and other styles

43

Jutooru, Indira Devi. "New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7860.

Full text

Abstract:

Methyl 2-cyano-3,11-dioxo-18b-olean-1,12-dien-30-oate (CDODA-Me) is a synthetic triterpenoid that inhibits growth of Panc1 and Panc28 pancreatic cancer cell lines and activates peroxisome proliferator-activated receptor B (PPARB)-dependent transactivation in these cells. CDODA-Me has also induced p21 and p27 protein expression and downregulated cyclin D1; however, these responses were receptor-independent. CDODA-Me induced apoptosis, which was accompanied by receptor-independent induction of the proapoptotic proteins early growth response-1 (Egr-1), nonsteroidal anti-inflammatory drug-activate

APA, Harvard, Vancouver, ISO, and other styles

44

Choene, Mpho Susan. "Screening of South African medicinal plant Euphorbia tirucalli for anticancer properties." Thesis, 2015. http://hdl.handle.net/10539/18527.

Full text

Abstract:

Thesis submitted to the Faculty of Science under the school of Molecular and Cell Biology, University of the Witwatersrand, in partial fulfilment of the requirements for PhD. Gauteng, Johannesburg, 2015<br>Cancer is an enormous burden of disease, accounting for millions of deaths annually worldwide. Today, more people are dying from cancer than HIV/AIDS, malaria and tuberculosis combined. According to the American Cancer Society, it is expected that the global cancer burden will double by 2030 if preventative measures are not applied. Breast and gynaecological cancers remains a big scourge in

APA, Harvard, Vancouver, ISO, and other styles

45

Zhang, Lin. "Biological activities and structural characterisation of anticancer herbal polysaccharides." Thesis, 2017. http://hdl.handle.net/1959.7/uws:45024.

Full text

Abstract:

In recent years, medicinal plants have become popular for the treatment of several diseases due to their efficacy and cost effectiveness. Plant derived therapeutic agents are increasingly sought out as pharmaceuticals for the treatment of life-threatening illnesses. Important contributions have already been made in the recent years to the drug market by the compounds isolated from natural sources or from their derivatives. There is no doubt that, novel lifesaving drugs could be discovered by a systematic evaluation of ethno medicinal information using modern scientific tools. This thesis atte

APA, Harvard, Vancouver, ISO, and other styles

46

Kirana, Chandra. "Potential anticancer activity of in rhizomes of ginger species (Zingiberaceae family)." 2003. http://hdl.handle.net/2440/58491.

Full text

Abstract:

Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library.<br>The aim of the work described in this thesis was initially to screen the ethanol extracts of eleven Indonesian ginger species (Zingiberaceae family) for anticancer activity. MCF-7 breast and HT-29 colon cancer cells were used for the investigations. Extracts of Zingiber aromaticum and Boesenbergia pandurata were found to be the most active species, similar to that of Curcuma langa which has been shown to possess anticancer activity in vitro and in vivo (A

APA, Harvard, Vancouver, ISO, and other styles

47

Pages, Benjamin J. "Polyaromatic anticancer platinum complexes : synthesis and analysis of DNA binding." Thesis, 2018. http://hdl.handle.net/1959.7/uws:47363.

Full text

Abstract:

Chemotherapy is a primary source of treatment for victims of cancer, a globally prominent disease that affects millions. The platinum(II) agents cisplatin, carboplatin and oxaliplatin are used in approximately half of all chemotherapy treatment schemes. These drugs kill cancerous cells by binding covalently to DNA and preventing replication, which leads to apoptosis. Despite the success of these drugs they have many debilitating side effects such as nephrotoxicity, myelotoxicity, nausea and vomiting. Furthermore, many cancers are resistant to treatment from these drugs, often through DNA repai

APA, Harvard, Vancouver, ISO, and other styles

48

Wu, Wei-De, and 吳韋德. "To investigate the effect of Antrodia cinnamomea extracts on the anticancer activity of drugs treatment in hepatocellular carcinoma cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/rt36e5.

Full text

Abstract:

碩士<br>嘉南藥理大學<br>生物科技系<br>103<br>Hepatocellular carcinoma (HCC) is the third most common malignancy worldwide. More than 75% of HCC cases occur in the Asia-Pacific region. In Taiwan, there are about 3,700 patients a year die from liver cancer. There are many chemical drugs have been used in liver cancer therapy. Antrodia cinnamomea is a medicinal fungus that has been served as a functional food in Taiwan for decades. Previous studies have shown that the secondary metabolites form Antrodia cinnamomea have various activities such as antitumor, protection of liver function, anti-inflammation and a

APA, Harvard, Vancouver, ISO, and other styles

49

Keter, Frankline Kiplangat. "Palladium, platinum and gold complexes: a synthetic approach towards the discovery of anticancer agents." Thesis, 2010. http://hdl.handle.net/10210/3074.

Full text

Abstract:

Ph.D.<br>Ligands bis(pyrazolyl)acetic acid (L1) and bis(3,5-dimethylpyrazolyl)acetic acid (L2) were synthesised by reacting pyrazoles and dibromoacetic acid under phase transfer conditions, by using benzyltriethylammonium chloride as the catalyst. Ligands L1 and L2 were characterised by a combination of 1H, 13C{1H} NMR, IR spectroscopy and microanalysis. Esterification of L1 and L2 led to formation of bis(pyrazolyl)ethyl acetate (L3) and bis(3,5-dimethylpyrazolyl)ethyl acetate (L4). Ligands L3 and L4 were also characterised by a combination of 1H, 13C{1H} NMR, IR spectroscopy and microanalysis

APA, Harvard, Vancouver, ISO, and other styles

50

Brabec, V., S. E. Howson, R. A. Kaner, et al. "Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?" 2013. http://hdl.handle.net/10454/9486.

Full text

Abstract:

Yes<br>Enantiomers of a relatively rigid DNA-binding metallo-helix are shown to have comparable activity to that of cisplatin against the cell lines MCF7 (human breast adenocarcinoma) and A2780 (human ovarian carcinoma) but are ca five times more active against the cisplatin-resistant A2780cis. The cell-line HCT116 p53+/+ (human colon carcinoma) is highly sensitive giving IC50 values in the nM range, far lower than the cisplatin control. The hypothesis that the biological target of such metallohelices is DNA is probed by various techniques. Tertiary structure changes in ct-DNA (formation

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!