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Journal articles on the topic 'Anticaries'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Vijaywargiya, Neelam, Manish Verma, Divya Saxena, Suparna Ganguly, Nilima Pagare, and Margie Khatri. "Anticaries vaccine." International Journal of Preventive and Clinical Dental Research 9, no. 1 (2022): 14. http://dx.doi.org/10.4103/ijpcdr.ijpcdr_3_22.

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2

Cheng, Lei, Jiyao Li, Libang He, and Xuedong Zhou. "Natural Products and Caries Prevention." Caries Research 49, Suppl. 1 (2015): 38–45. http://dx.doi.org/10.1159/000377734.

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Dental caries is considered as the most common polymicrobial oral disease in the world. With the aim of developing alternative approaches to reduce or prevent the decay, numerous papers showed the potential anticaries activity of a number of natural products. The natural products with anticaries effects are selected from e.g. food, beverages, flowers or traditional herbs. Most of the effective components are proven to be polyphenol compounds. Many of the natural products are studied as antibacterial agents, while some of them are found to be effective in shifting the de-/remineralization balan
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3

Forward, G. C. "Non-Fluoride Anticaries Agents." Advances in Dental Research 8, no. 2 (1994): 208–14. http://dx.doi.org/10.1177/08959374940080021201.

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Many potential anticaries agents other than fluoride have been identified in a range of laboratory models. This review covers only those agents which have demonstrated significant activity in either animal caries models, in situ models, or human clinical trials, including those measuring plaque acid formation. The agents which so far have been identified can be divided into 5 categories: (1) phosphorus-containing agents, (2) calcium-containing agents, (3) antimicrobials and antibiotics, (4) metals, and (5) miscellaneous agents. Although many potential agents have been identified in various mod
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4

Li, Hao, Chenguang Niu, Junyuan Luo, Zhengwei Huang, and Wei Zhou. "Anticariogenic Activity of Celastrol and Its Enhancement of Streptococcal Antagonism in Multispecies Biofilm." Antibiotics 12, no. 8 (2023): 1245. http://dx.doi.org/10.3390/antibiotics12081245.

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Dental caries is a chronic disease resulting from dysbiosis in the oral microbiome. Antagonism of commensal Streptococcus sanguinis and Streptococcus gordonii against cariogenic Streptococcus mutans is pivotal to keep the microecological balance. However, concerns are growing on antimicrobial agents in anticaries therapy, for broad spectrum antimicrobials may have a profound impact on the oral microbial community, especially on commensals. Here, we report celastrol, extracted from Traditional Chinese Medicine’s Tripterygium wilfordii (TW) plant, as a promising anticaries candidate. Our results
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5

Wu, Tianmu, Bolei Li, Xuedong Zhou, et al. "Evaluation of Novel Anticaries Adhesive in a Secondary Caries Animal Model." Caries Research 52, no. 1-2 (2017): 14–21. http://dx.doi.org/10.1159/000481832.

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We investigated the anticaries properties of an adhesive containing dimethylaminododecyl methacrylate (DMADDM) in vivo via a secondary caries animal model. Cavities were prepared in the maxillary first molars of Wistar rats. DMADDM-containing adhesives were applied on one side and commercial adhesives on the opposite side as a control. After a 3-week feeding period to induce secondary caries, the molars were harvested for the evaluation of the secondary caries. Lesion depth (LD) and mineral loss (ML) were measured via a micro-CT method, and a modified Keyes scoring method yielded scores for th
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6

ten Cate, J. M. "Novel Anticaries and Remineralizing Agents." Journal of Dental Research 91, no. 9 (2012): 813–15. http://dx.doi.org/10.1177/0022034512455032.

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7

Gazzani, Gabriella, Maria Daglia, and Adele Papetti. "Food components with anticaries activity." Current Opinion in Biotechnology 23, no. 2 (2012): 153–59. http://dx.doi.org/10.1016/j.copbio.2011.09.003.

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8

Benedito, Larissa Caroliny de Brito, Antônio Pedro Ricomini-Filho, Cinthia Pereira Machado Tabchoury, and Jaime Aparecido Cury. "Anticaries potential of a fluoride foam." Brazilian Dental Journal 34, no. 1 (2023): 89–98. http://dx.doi.org/10.1590/0103-6440202305287.

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Abstract Foam has been used worldwide as a vehicle for the professional application of fluoride and hypothetically should have the same anticaries potential as conventional fluoride gel (F-gel) in terms of the formation of reaction products with enamel. Thus, the ability of Flúor Care® foam (FGM, Joinville, SC, Brazil, 12,300 ppm F, acidulated) to react with enamel was evaluated in comparison with Flúor gel® (DFL, Rio de Janeiro, RJ, Brazil, 12,300 ppm F, acidulated). Slabs (n=10/group) of sound enamel and with caries lesion were used, in which the concentrations of total fluoride (TF), and lo
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9

Cheng, L., K. Zhang, N. Zhang, et al. "Developing a New Generation of Antimicrobial and Bioactive Dental Resins." Journal of Dental Research 96, no. 8 (2017): 855–63. http://dx.doi.org/10.1177/0022034517709739.

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Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed. Syne
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10

Das, Diptajit, J. Avinash, S. Vinay, Kunal Jha, BS Goutham, and Gunjan Kumar. "The unexplored anticaries potential of shiitake mushroom." Pharmacognosy Reviews 10, no. 20 (2016): 100. http://dx.doi.org/10.4103/0973-7847.194039.

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11

Badekova, Karakoz, Gayane Atazhanova, Irina Losseva, Aigul Medeshova, Ailazzat Aitkenova, and Anar Brazhanova. "Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice." Journal of Toxicology 2023 (September 14, 2023): 1–6. http://dx.doi.org/10.1155/2023/6691694.

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Objectives. The creation of new herbal medicines for their use in dentistry is relevant. The purpose of this work is to study the acute toxicity of the anticaries dental gel (ACDG3) developed by us based on Origanum vulgare. Results. In case of studying the safety of anticaries dental gel “ACDG3” in animals, that with a single dose of up to 2000 mg/kg, the absence of pathological changes in the behavior of animals was noted. Biochemical studies indicate that the studied doses of dental gel did not lead to significant deviations in the blood parameters of mice and deviations fluctuated within t
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12

Bang, Vania Christina Budiono, Rebriarina Hapsari, and Ira Anggar Kusuma. "Antibacterial Activity of Euphorbia tirucalli against Lactobacillus acidophilus: An In Vitro Study." Majalah Obat Tradisional 29, no. 1 (2024): 6. http://dx.doi.org/10.22146/mot.86604.

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Dental caries is a common oral disease that occurs due to excessive interaction between tooth structure, bacterial biofilm, and glucose. Lactobacillus acidophilus is the main cause of dentin dental caries, which can be prevented using anticaries agents. However, current anticaries agents may cause some side effects. Therefore, there is a need for natural anticaries agents with minimal side effects. Euphorbia tirucalli contains flavonoids, tannins, and saponins that contribute to its antibacterial activity. This study aimed to determine the antibacterial activity of E. tirucalli against L. acid
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13

Priyadi, Muhammad, and Rizki Rachmad Saputra. "Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach." CHEMPUBLISH JOURNAL 7, no. 1 (2023): 18–30. http://dx.doi.org/10.22437/chp.v7i1.26098.

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Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans. Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5%
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14

T R, Prashith Kekuda, and Vinayaka K S. "In Vitro Anticaries Activity of Some Macrolichens of Karnataka, India." International Journal of Pharma Research and Health Sciences 4, no. 3 (2016): 1244–48. http://dx.doi.org/10.21276/ijprhs.2016.03.16.

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15

Tokmakova, S. I., O. V. Bondarenko, E. A. Kirienkova, et al. "Clinical and laboratory evaluation of the effectiveness of children's toothpastes containing 1000 ppm fluoride." Pediatric dentistry and dental prophylaxis 24, no. 3 (2024): 249–58. http://dx.doi.org/10.33925/1683-3031-2024-828.

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Relevance. This article presents the findings from studies evaluating the effectiveness of toothpastes containing 1000 ppm fluoride in clinical settings. The data demonstrates the cumulative benefits of these toothpastes on oral hygiene, the reduction of inflammatory oral manifestations, and their anticaries effects.Purpose. To assess the effectiveness of fluoride-containing toothpastes through laboratory tests and clinical trials.Materials and methods. The study evaluated the effectiveness of toothpastes containing 1000 ppm fluoride using the following parameters: Greene-Vermillion hygiene in
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16

Lee, Moonkyung, and Young Sun Hwang. "Anticaries Effect of Ethanol Extract of Terminalia chebula." Journal of Dental Hygiene Science 21, no. 2 (2021): 119–26. http://dx.doi.org/10.17135/jdhs.2021.21.2.119.

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17

N/A. "New Dentifrice for Sensitivity Shows Strong Anticaries Effect." Biological Therapies in Dentistry 19, no. 06 (2004): 21. http://dx.doi.org/10.2310/7040.2004.19605.

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18

Wang, Xiuqing, Yufei Wang, Kun Wang, et al. "Bifunctional anticaries peptides with antibacterial and remineralizing effects." Oral Diseases 25, no. 2 (2018): 488–96. http://dx.doi.org/10.1111/odi.12990.

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19

Featherstone, J. D., M. Fontana, and M. Wolff. "Novel Anticaries and Remineralization Agents: Future Research Needs." Journal of Dental Research 97, no. 2 (2018): 125–27. http://dx.doi.org/10.1177/0022034517746371.

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20

Heifetz, Stanley B., Abraham Yaari, and Howard Proskin. "Anticaries Effectiveness of a Fluoride and Nonfluoride Sealant." Journal of the California Dental Association 35, no. 8 (2007): 573–77. http://dx.doi.org/10.1080/19424396.2007.12221260.

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21

Tenuta, L. M. A., R. V. Cerezetti, A. A. Del Bel Cury, C. P. M. Tabchoury, and J. A. Cury. "Fluoride Release from CaF2 and Enamel Demineralization." Journal of Dental Research 87, no. 11 (2008): 1032–36. http://dx.doi.org/10.1177/154405910808701105.

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The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF2) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF2 formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase of F availability in fluid of subsequently formed plaque. We created distinct levels of CaF2 on enamel to evaluate a dose-response effect. Enamel blocks were mounted in contact with a S. mutans test plaque and used in situ by 10 volunteers. F released to the fluid phase of this substr
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22

Cury, Jaime A., Antonio P. Ricomini-Filho, Francine L. Perecin Berti, and Cinthia PM Tabchoury. "Systemic Effects (Risks) of Water Fluoridation." Brazilian Dental Journal 30, no. 5 (2019): 421–28. http://dx.doi.org/10.1590/0103-6440201903124.

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Abstract Since the 1950s, the benefits and risks of fluoridated water use have been debated worldwide. In the past, it was considered that the systemically ingested fluoride would exert its primary preventive effect after being incorporated into the enamel as fluorapatite, making the enamel more resistant to the caries process; however, it is now recognized that the main effect of water fluoridation is local and post eruptive. On the other hand, irrespective of the caries decline reported worldwide, the anticaries benefit of water fluoridation continues to be observed even in developed countri
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23

Lakshmi Priya, Dr S., Dr Raghunathan Jagannathan, Dr Thodur Madapusi Balaji, et al. "Resveratrol And Green Coffee Extract Gel As Anticaries Agent." Indian Journal of Research in Pharmacy and Biotechnology 8, no. 5 (2020): 15–21. http://dx.doi.org/10.31426/ijrpb.2020.8.5.8512.

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24

Krishnakumar, Gauri, Dhananjaya Gaviappa, and Shwetha Guruswamy. "Anticaries Efficacy of Liquorice Lollipop: An ex vivo Study." Journal of Contemporary Dental Practice 19, no. 8 (2018): 937–42. http://dx.doi.org/10.5005/jp-journals-10024-2361.

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25

Krasse, B., C. G. Emilson, and L. Gahnberg. "An Anticaries Vaccine: Report on the Status of Research." Caries Research 21, no. 3 (1987): 255–76. http://dx.doi.org/10.1159/000261029.

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26

Otake, S., M. Makimura, T. Kuroki, Y. Nishihara, and M. Hirasawa. "Anticaries Effects of Polyphenolic Compounds from Japanese Green Tea." Caries Research 25, no. 6 (1991): 438–43. http://dx.doi.org/10.1159/000261407.

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27

Rosin-Grget, K., and I. Lincir. "Anticaries Effect of Different Amine Fluoride Concentrations in Schoolchildren." Caries Research 29, no. 3 (1995): 168–71. http://dx.doi.org/10.1159/000262064.

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28

Garcia, Luhana Santos Gonzales, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, et al. "Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate." Clinical Oral Investigations 23, no. 9 (2018): 3535–42. http://dx.doi.org/10.1007/s00784-018-2773-7.

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29

Fukuizumi, Takaki, Hiromasa Inoue, Toshiyuki Tsujisawa, and Choji Uchiyama. "Tonsillar Application of Formalin-Killed Cells ofStreptococcus sobrinus Reduces Experimental Dental Caries in Rabbits." Infection and Immunity 67, no. 1 (1999): 426–28. http://dx.doi.org/10.1128/iai.67.1.426-428.1999.

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ABSTRACT Living Streptococcus sobrinus cells were orally inoculated into nonimmune rabbits and rabbits immunized with formalin-killed cells of S. sobrinus through tonsillar application to examine the anticaries potential of this method of immunization. The living S. sobrinus cell numbers and the caries areas in the rabbits immunized by tonsillar application decreased to a level one-fifth of that in nonimmune rabbits.
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30

I. Spielman, Andrew, and Judit Forrai. "History of caries arresting - prevention." Kaleidoscope history 14, no. 28 (2024): 385–87. http://dx.doi.org/10.17107/kh.2024.28.21.

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The initial observation of fluoride's ability to decrease caries rates can be attributed to Antoine Malagou Desirabode in 1843. Subsequently, Frederick McKay, GV. Black, and Trendley H. Dean made substantial contributions to understanding its anticaries effects. The introduction of fluoridation into water, toothpaste, and other mediums marked one of the most impactful public health interventions, resulting in a significant reduction in caries rates.
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31

Solovyeva, Zh V., A. A. Adamchik, E. S. Zaporozhskaya-Abramova, and V. V. Tairov. "Study of clinical efficacy of anticaries paste with hydroxyapatite and mummy." Stomatology for All / International Dental review, no. 2(111) (June 20, 2025): 15–19. https://doi.org/10.35556/idr-2025-2(111)15-19.

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The personal choice of toothpaste largely determines the quality of hygiene and preventive measures. The large number of toothpastes on the market of the most diverse range of toothpastes makes the selection process difficult for the doctor and the patient. In this regard, the study of activity and effectiveness of therapeutic and preventive toothpastes is a prerequisite for the successful choice of personal oral hygiene products. The purpose. By means of enamel resistance test, acid biopsy and hygienic index to evaluate the prophylactic and remineralizing efficacy of «Anticaries paste with hy
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32

Marquis, Robert E. "Antimicrobial actions of fluoride for oral bacteria." Canadian Journal of Microbiology 41, no. 11 (1995): 955–64. http://dx.doi.org/10.1139/m95-133.

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Fluoride is widely used as a highly effective anticaries agent. Although it is felt that its anticaries action is related mainly to effects on mineral phases of teeth and on the process of remineralization, fluoride also has important effects on the bacteria of dental plaque, which are responsible for the acidification of plaque that results in demineralization. The results of recent studies have shown that fluoride can affect bacterial metabolism through a set of actions with fundamentally different mechanisms. It can act directly as an enzyme inhibitor, for example for the glycolytic enzyme
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33

NAKASHIMA, Shoji, Kunitomo SUZUKI, Akiko SUZUKI, Takashi UJIIE, and Yoshihito OCHIAI. "Anticaries Efficacy of Sodium Phytate-containing SnF2 Dentifrice In vitro." JOURNAL OF DENTAL HEALTH 35, no. 2 (1985): 195–202. http://dx.doi.org/10.5834/jdh.35.195.

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34

Delbem, Alberto Carlos Botazzo, Maurício Bergamaschi, Eliana Rodrigues, Kikue Takebayashi Sassaki, Ana Elisa de Mello Vieira, and Emilene Macario Coimbra Missel. "Anticaries effect of dentifrices with calcium citrate and sodium trimetaphosphate." Journal of Applied Oral Science 20, no. 1 (2012): 94–98. http://dx.doi.org/10.1590/s1678-77572012000100017.

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35

Sun, Frank C., E. Eric Engelman, James A. McGuire, et al. "Impact of an Anticaries Mouthrinse onIn VitroRemineralization and Microbial Control." International Journal of Dentistry 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/982071.

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Objective. The objective of this research was to evaluate the caries control potential of a new fluoride mouthrinse that also contained antimicrobial agents and a biofilm disrupting agent using differentin vitromodels.Methods. Fourin vitrostudies were conducted to assess the performance of this three pronged approach to caries control: (1) traditional enamel fluoride uptake, (2) surface microhardness study using pH cycling model and subsequent fluoride uptake, (3) a salivary biofilm flow-through study to determine the anti-microbial activity, and (4) a single species biofilm model measuring ef
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36

Featherstone, J. D., and S. Doméjean. "The Role of Remineralizing and Anticaries Agents in Caries Management." Advances in Dental Research 24, no. 2 (2012): 28–31. http://dx.doi.org/10.1177/0022034512452885.

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37

Wolff, M. S., and A. B. Schenkel. "The Anticaries Efficacy of a 1.5% Arginine and Fluoride Toothpaste." Advances in Dental Research 29, no. 1 (2018): 93–97. http://dx.doi.org/10.1177/0022034517735298.

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38

Dehailan, L. Al, EA Martinez-Mier, GJ Eckert, and F. Lippert. "An In Vitro Investigation of Anticaries Efficacy of Fluoride Varnishes." Operative Dentistry 44, no. 5 (2019): E234—E243. http://dx.doi.org/10.2341/18-040-l.

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SUMMARY Most currently marketed fluoride varnishes (FVs) have not been evaluated for their effectiveness in preventing dental caries. The objective of this study was to investigate the anticaries efficacy, measured as fluoride release into artificial saliva (AS); change in surface microhardness of early enamel caries lesions; and enamel fluoride uptake (EFU) of 14 commercially available FVs and two control groups. Bovine enamel specimens (5×5 mm) were prepared and assigned to 18 groups (n=12). Early caries lesions were created in the specimens and characterized using Vickers microhardness (VHN
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39

Marks, R. G., R. D'Agostino, J. E. Moorhead, A. J. Conti, and L. Cancro. "A Fluoride Dose-response Evaluation in an Anticaries Clinical Trial." Journal of Dental Research 71, no. 6 (1992): 1286–91. http://dx.doi.org/10.1177/00220345920710060401.

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This study evaluated the dose-response relationship between four increasing levels of fluoride from 1000 to 2500 ppm F as sodium monofluorophosphate (MFP) and three-year dental caries increments, as measured by DMFS, DMFT, and DFS-A on 4424 schoolchildren. The results indicated consistent linear decreases in all three dental indices as the dose level increased to 2500 ppm F MFP, with slopes (average reductions) of 0.32 in DMFS for an increase of 1000 ppm F, 0.13 in DMFT, and 0.17 in DFS-A when all children were evaluated, p < 0.03 for each index. For children 11 years and older at baseline,
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40

Shouji, N., K. Takada, K. Fukushima, and M. Hirasawa. "Anticaries Effect of a Component from Shiitake (an Edible Mushroom)." Caries Research 34, no. 1 (1999): 94–98. http://dx.doi.org/10.1159/000016559.

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41

White, D. J. "The Application of in Vitro Models to Research on Demineralization and Remineralization of the Teeth." Advances in Dental Research 9, no. 3 (1995): 175–93. http://dx.doi.org/10.1177/08959374950090030101.

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Progress in in vivo and in situ experimentation has led many researchers to speculate as to the relevance and importance of in vitro testing protocols in caries research. A Medline/Biosis search for the present review revealed well over 300 citations (since 1989) documenting in vitro tests associated with caries research on mineralization and fluoride reactivity. The present survey documents these recent applications of in vitro test methods in both mechanistic and 'profile'* caries research. In mechanistic studies, in vitro protocols over the past five years have made possible detailed studie
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42

Zorrilla-Reyes, Sheyla. "pH values of fluoride mouthwashes marketed in Peru: an observational study." eVitroKhem 1 (December 30, 2022): 11. https://doi.org/10.56294/evk202211.

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The objective of this research was to determine the average pH value of fluoride mouthwashes marketed in Peru. The methodological design was experimental-descriptive. Seven commercial brands were evaluated, with a sample of 21 fluoride mouthwashes, three per group, Colgate Plax Ice Glacial Zero Alcohol, Colgate Plax Soft Mint Zero Alcohol, Listerine Total Care Zero, Listerine Anticaries, Oral B Complete, Dento Menta Zero Alcohol and Vitis Orthodontic; a previously calibrated digital pH meter was used to measure the pH and the data was processed with ANOVA and Tukey tests, finding statistically
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43

Favaro, Jaqueline Costa, Tiago Roberto Detomini, Luciana Prado Maia, et al. "Anticaries Agent Based on Silver Nanoparticles and Fluoride: Characterization and Biological and Remineralizing Effects—An In Vitro Study." International Journal of Dentistry 2022 (April 19, 2022): 1–11. http://dx.doi.org/10.1155/2022/9483589.

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Objective. The aim of the study was to characterize and evaluate the stability, antimicrobial activity, cytotoxicity, and remineralizing effects of silver nanoparticles and fluoride anticaries agent (AgF) on staining dental enamel. Materials and Methods. An experimental AgF solution was prepared and compared to silver diamine fluoride (SDF). First, the AgF was characterized and the stability was evaluated by transmission electron microscopy (TEM). Streptococcus mutans, Enterococcus faecalis, and Escherichia coli strains were used to evaluate the minimum inhibitory and bactericidal concentratio
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44

Ratti, Pichayaporn, Jutharat Manuschai, Jiraporn Kara, Luelak Lomlim, and Supawadee Naorungroj. "In Vitro Antimicrobial, Antiglycolytic, and Antibiofilm Activities of Synthetic 1,4-Naphthoquinone Derivatives against Cariogenic Bacteria." Sains Malaysiana 52, no. 1 (2023): 199–210. http://dx.doi.org/10.17576/jsm-2023-5201-16.

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This study investigated the potential anticaries properties of synthetic 1,4-naphthoquinone derivatives. Synthetic 1,4-naphthoquinone derivatives (2-4) were designed and synthesized by employing lawsone methyl ether (LME, 1), a plant-derived 1,4-naphthoquinone, as a lead compound. The synthetic compounds were characterized by infrared spectroscopy, 1H-nuclear magnetic spectroscopy, 13C- nuclear magnetic spectroscopy, and high-resolution mass spectrometry. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and growth curves were determined to assess their antibact
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45

Ortiz, Adriana de Cássia, Livia Maria Andaló Tenuta, Cínthia Pereira Machado Tabchoury, and Jaime Aparecido Cury. "Anticaries Potential of Low Fluoride Dentifrices Found in The Brazilian Market." Brazilian Dental Journal 27, no. 3 (2016): 298–302. http://dx.doi.org/10.1590/0103-6440201600729.

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Abstract Low-fluoride (F) dentifrices (<600 µg F/g) are widely available worldwide, but evidence to recommend the use of such dentifrices, with either regular or improved formulations, is still lacking. Therefore, the aim of this study was to evaluate the anticaries potential of low-F dentifrices found in the Brazilian market, using a validated and tested pH-cycling model. Enamel blocks were selected by surface hardness (SH) and randomized into four treatment groups (n=12): non-F dentifrice (negative control), low-F dentifrice (500 μg F/g), low-F acidulated dentifrice (550 μg F/g) and 1,100
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46

Xie, Q., J. Li, and X. Zhou. "Anticaries effect of compounds extracted fromGalla Chinensisin a multispecies biofilm model." Oral Microbiology and Immunology 23, no. 6 (2008): 459–65. http://dx.doi.org/10.1111/j.1399-302x.2008.00450.x.

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47

Gel’mbol’dt, V. O., V. Yu Anisimov, I. O. Shishkin, M. S. Fonar’, and V. Kh Kravtsov. "Synthesis, Structure, and Anticaries Activity of 2-Amino-4,6-Dihydroxypyrimidinium Hexafluorosilicate." Pharmaceutical Chemistry Journal 52, no. 7 (2018): 606–10. http://dx.doi.org/10.1007/s11094-018-1868-4.

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48

White, D. J., D. G. A. Nelson, and R. V. Faller. "Mode of Action of Fluoride: Application of New Techniques and Test Methods to the Examination of the Mechanism of Action of Topical Fluoride." Advances in Dental Research 8, no. 2 (1994): 166–74. http://dx.doi.org/10.1177/08959374940080020601.

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Abstract:
Modern techniques in dental research continue to assist in the study of the mode of (anticaries) action of topical fluorides. The Plaque Glycolysis and Regrowth Model (PGRM) facilitates the standardized assessments of antimicrobial effects on plaque following use of test formulations in vivo without complications arising from coincident mineral reactivity. In vivo plaque glycolysis testing demonstrates that topically applied fluoride, at conventional levels found in dentifrices, has only modest effects on the metabolic (acid-producing) activity of dental plaque. Any 'plaque' contribution to fl
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49

Batista, Milene Tavares, Renata D. Souza, Ewerton L. Ferreira, et al. "Immunogenicity andIn VitroandIn VivoProtective Effects of Antibodies Targeting a Recombinant Form of the Streptococcus mutans P1 Surface Protein." Infection and Immunity 82, no. 12 (2014): 4978–88. http://dx.doi.org/10.1128/iai.02074-14.

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ABSTRACTStreptococcus mutansis a major etiologic agent of dental caries, a prevalent worldwide infectious disease and a serious public health concern. The surface-localizedS. mutansP1 adhesin contributes to tooth colonization and caries formation. P1 is a large (185-kDa) and complex multidomain protein considered a promising target antigen for anticaries vaccines. Previous observations showed that a recombinant P1 fragment (P139–512), produced inBacillus subtilisand encompassing a functional domain, induces antibodies that recognize the native protein and interfere withS. mutansadhesionin vitr
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Casals, Elias, Tchilalo Boukpessi, Christina M. McQueen, Sandy L. Eversole, and Robert V. Faller. "Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency." Journal of Contemporary Dental Practice 8, no. 7 (2007): 1–10. http://dx.doi.org/10.5005/jcdp-8-7-1.

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Abstract Aim The aim of this in vitro study was to investigate fluoride uptake in human enamel after use of commercially available toothpastes containing different fluoride compounds, or combinations of fluoride actives formulated into a single product, as a means of determining the efficiency of each formula for delivering caries preventing fluoride to demineralized (caries active) enamel. Methods and Materials Four test dentifrices and two controls were assessed and placed in groups as follows: Group 1: Lacer® (Spain); Group 2: Positive control-USP Reference Standard 1100 ppm F; Group 3: Flu
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