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Journal articles on the topic 'Anticonvulsant agents'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Mishchenko, Mariia, Sergiy Shtrygol, Danylo Kaminskyy, and Roman Lesyk. "Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents." Scientia Pharmaceutica 88, no. 1 (2020): 16. http://dx.doi.org/10.3390/scipharm88010016.

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Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores. The structure of target compounds was based on the following: (i) A combination of two thiazole cores; (ii) similarity to ralitolin’s structure; (iii) the compliance with structural requirements for the new anticonvulsants. Target compounds were synthesized via known approaches based on Knoenavegel reaction, alkylation reaction, and one-pot three-component reaction. Anticonvulsant properties of compounds were evaluated in t

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2

Dreifuss, Fritz E. "Anticonvulsant Agents." Critical Care Clinics 7, no. 3 (1991): 521–32. http://dx.doi.org/10.1016/s0749-0704(18)30294-x.

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3

Trisovic, Nemanja, Gordana Uscumlic, and Slobodan Petrovic. "Hydantoins: Synthesis, properties and anticonvulsant activity." Chemical Industry 63, no. 1 (2009): 17–31. http://dx.doi.org/10.2298/hemind0901017t.

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Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

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Banjac, Nebojsa, Nemanja Trisovic, Natasa Valentic, Gordana Uscumlic, and Slobodan Petrovic. "Succinimides: Synthesis, properties and anticonvulsant activity." Chemical Industry 65, no. 4 (2011): 439–53. http://dx.doi.org/10.2298/hemind110224030b.

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Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

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5

Malawska, Barbara. "New Anticonvulsant Agents." Current Topics in Medicinal Chemistry 5, no. 1 (2005): 69–85. http://dx.doi.org/10.2174/1568026053386944.

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6

Yaduwanshi, Phool Singh, Sheelu Singh, Prinsi Sahapuriya, Priyanka Dubey, Jyoti Thakur, and Savita Yadav. "Synthesis of Some Noval Qunazolinone Derivatives for their Anticonvulsant Activity." Oriental Journal Of Chemistry 40, no. 2 (2024): 369–73. http://dx.doi.org/10.13005/ojc/400207.

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The quinoline family comprises an appealing group of heterocyclic compounds, with quinazolinones and their synthetic analogs being of particular interest. To synthesize 3- amino 2-phenyl quinazolinones, anthranilic acid and its substituted derivatives were employed as initial materials. The MES method was utilized to evaluate the anticonvulsant activity of the developed substances on albino mice, with phenytoin serving as a benchmark anticonvulsant medication.The synthesized compounds demonstrated noteworthy anticonvulsant activity, comparable to that of established prescription medications. A

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7

Mayor, M. Marin, J. Lopez Alvarez, M. D. Riaza Perez, A. Quintana Perez, and G. Rubio Valladolid. "Use of anticonvulsant agents in the management of alcohol dependence." European Psychiatry 26, S2 (2011): 78. http://dx.doi.org/10.1016/s0924-9338(11)71789-8.

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BackgroundAlcoholism is a chronic relapsing disorder characterized by compulsive drinking, alcohol seeking, loss of control over alcohol consumption, and impaired social and occupational functioning. Treatment of Alcohol Dependence (AD) comprises two steps, detoxification and relapse prevention (RP). Traditionally, long half-life benzodiazepines have been the most widely used agents for alcohol detoxification. On the other hand, disulfiram, naltrexone and acamprosate are the three drugs that have been approved for relapse prevention. In the last decades, nevertheless, there is a growing intere

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8

Goodwin, Frederick K., and S. Nassir Ghaemi. "The Impact of Mood Stabilizers on Suicide in Bipolar Disorder: A Comparative Analysis." CNS Spectrums 5, S1 (2000): 12–18. http://dx.doi.org/10.1017/s1092852900023245.

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AbstractWhich mood stabilizers are the most effective in reducing suicide rates in patients with bipolar disorder? This paper reviews the literature and compares the data on two types of mood-stabilizing agents, lithium and anticonvulsants. Compared with the large amount of data on lithium, there is surprising little information available on the effects of anticonvulsants on mortality in manic-depressive illness. Each was also assessed in terms of suicide risk factors such as depression and mixed episodes, rapid cycling, substance abuse, anxiety and panic, and central serotonergic function. On

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9

Nair, B. R. "Anticonvulsant agents and osteomalacia." Medical Journal of Australia 152, no. 5 (1990): 279–80. http://dx.doi.org/10.5694/j.1326-5377.1990.tb120938.x.

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10

Jakovleva, Ekaterina E., Stanislav P. Foksha, Marija A. Brusina, et al. "Studying the anticonvulsive activity of new ligands of NDMA-receptor complex – imidazole-4,5-dicarbonic acid derivatives." Reviews on Clinical Pharmacology and Drug Therapy 18, no. 2 (2020): 149–54. http://dx.doi.org/10.17816/rcf182149-154.

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NMDA receptors were proven to play a significant role in the processes of epileptogenesis. Experimental data indicate a significant anticonvulsant effect of NMDA receptor antagonists, but the use of the studied NMDA ligands remains limited due to their low efficiency and toxic effects. The aim of the study was to investigate the anticonvulsant effect of new ligands of the glutamate NMDA receptor complex imidazole-4,5-dicarboxylic acid (IDA) derivatives on a model of NMDA-induced convulsions in mice. The tested agents (IEM2258 and IEM2248) were injected into the lateral ventricles of a waking m

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11

Kamiński, Jakubiec, Zagaja, Andres-Mach, Mogilski, and Latacz. "New TRPV1 Antagonists as Candidates for Effective Anticonvulsant and Antinociceptive Agents." Proceedings 22, no. 1 (2019): 30. http://dx.doi.org/10.3390/proceedings2019022030.

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Epilepsy is recognized as one of the most common neurological disorders with a high risk of drug resistance. Notably, about one-third of the patients with epilepsy are not responsive to pharmacological treatment. Thus, the search for new, more effective anticonvulsants with a novel mechanism of action is undoubtedly necessary. The most recent neurobiological studies implicate central TRPV1 receptors in the induction of epileptic seizures. Moreover, it is suggested that TRPV1 desensitization is one of the crucial mechanisms of action responsible for the anticonvulsant activity of cannabidiol (C

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12

Rajak, Harish, Ravichandran Veerasamy, Arun Kumar Gupta, Murli Dhar Kharya, and Pradeep Mishra. "Synthesis and Pharmacological Evaluation of New Indolyl-oxadiazoles as Anticonvulsant Agents." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 661–66. http://dx.doi.org/10.37285/ijpsn.2009.2.3.10.

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The search for better anticonvulsant drug and the importance of 2,5-disubstituted 1,3,4-oxadiazoles and indole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles for their potential anticonvulsant activity. The structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR, 13C NMR and MS) analyses. Most of the test compounds demonstrated appreciable anticonvulsant activities in maximal electroshock seizure (MES) and subcutaneous pentylenetrtrazole (scPTZ) models.

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13

Kelly, Daniel F., and Donald G. Hope. "Fatal Phenytoin-Related Toxic Epidermal Necrolysis: Case Report." Neurosurgery 25, no. 6 (1989): 976–78. http://dx.doi.org/10.1227/00006123-198912000-00022.

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Abstract Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head injury. The typical course and current management of toxic epidermal necrolysis are reviewed, as are the indications for the prophylaxis of posttraumatic epilepsy.

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14

Pele, Raluca, Gabriel Marc, Cristina Mogoșan, et al. "Synthesis, In Vivo Anticonvulsant Activity Evaluation and In Silico Studies of Some Quinazolin-4(3H)-one Derivatives." Molecules 29, no. 9 (2024): 1951. http://dx.doi.org/10.3390/molecules29091951.

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Two series, “a” and “b”, each consisting of nine chemical compounds, with 2,3-disubstituted quinazolin-4(3H)-one scaffold, were synthesized and evaluated for their anticonvulsant activity. They were investigated as dual potential positive allosteric modulators of the GABAA receptor at the benzodiazepine binding site and inhibitors of carbonic anhydrase II. Quinazolin-4(3H)-one derivatives were evaluated in vivo (D1–3 = 50, 100, 150 mg/kg, administered intraperitoneally) using the pentylenetetrazole (PTZ)-induced seizure model in mice, with phenobarbital and diazepam, as reference anticonvulsan

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15

Wang, Po W., Terence A. Ketter, Olga V. Becker, and Cecylia Nowakowska. "New Anticonvulsant Medication Uses in Bipolar Disorder." CNS Spectrums 8, no. 12 (2003): 930–47. http://dx.doi.org/10.1017/s1092852900028704.

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ABSTRACTTherapy of bipolar disorders is a rapidly evolving field. Lithium has efficacy in classic bipolar disorders whereas divalproex sodium and carbamazepine may have broader spectrum efficacy that includes non-classic bipolar disorder. In the last 10 years, a series of anticonvulsants have been approved for marketing in the United States. Gabapentin has indirect γ-aminobuytric acid-ergic actions, is generally well tolerated, and appears to have anxiolytic, analgesic, and hypnotic effects. Lamotrigine has antiglutamatergic actions and is generally well tolerated (aside from rash in 1 in 10,

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16

Sydorenko, Ivan A., Marija V. Mishchenko, Serhii Yu Shtrygol’, et al. "The synthesis and the anticonvulsant activity screening of new 5-substituted 2-imino-4-thiazolidinone derivatives." Journal of Organic and Pharmaceutical Chemistry 20, no. 1(77) (2022): 12–20. http://dx.doi.org/10.24959/ophcj.22.248784.

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Aim. To synthesize 5-ene-4-thiazolidinones containing heterocyclic rings in the molecule as potential anticonvulsants, and screen their anticonvulsant activity on a model of pentylenetetrazole (PTZ) seizures.Results and discussion. A straightforward and convenient synthesis of novel 5-ene-derivatives of thiazol/oxazole-bearing 4-thiazolidinones as possible anticonvulsant agents was performed. Compounds were characterized using methods of spectral analysis (1H NMR and LC-MS). 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde underwent the aminolysis on a chlorine atom by a molecule of monoe

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17

Garg, Ajay kumar. "Screening of semicarbazones as anticonvulsant agents." Medicinal Chemistry 11, no. 10 (2021): 6. https://doi.org/10.5281/zenodo.10669307.

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The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. Method: In this project, the synthesis of semicarbazone derivatives was carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semic

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18

P., S. UPADHYAY, N. JOSHI S., J. BAXI A., and R. PARIKH A. "Synthesis of 1,4-Bis(5'-substituted-benzylidene-2' -phenyl/methyl-4 '-imidazolinone-3'-ylamino)-phthalazine as Potential Anticonvulsant Agents." Journal of Indian Chemical Society Vol. 68, Jun 1991 (1991): 364–65. https://doi.org/10.5281/zenodo.6158064.

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Department of Chemistry. Saurashtra University, Rajkot-360 005 <em>Manuscript received 4 September 1990, revised 7 March 1991, accepted 31 May 1991</em> Synthesis of 1,4-Bis(5'-substituted-benzylidene-2' -phenyl/methyl-4 '-imidazolinone-3'-ylamino)-phthalazine as Potential Anticonvulsant Agents.

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19

V, Vani, Fathimathul Nafiya, Harshad A, Mahima Krishnan M M, Naisam N, and Sneha Saji. "In-Silico Design of Thiadiazole Derivatives as Anticonvulsant Agents." Asian Journal of Pharmaceutical Research and Development 12, no. 4 (2024): 85–91. http://dx.doi.org/10.22270/ajprd.v12i4.1445.

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This study focuses on the in-silico design and molecular docking of thiadiazole and its derivatives to evaluate their potential as anticonvulsant agents.Thiadiazoles are heterocyclic compounds known for their diverse biological activities, including anticonvulsant properties.The molecular structures were subjected to various in-silico screening methods to predict their drug-like properties and pharmacokinetic profiles. Molecular docking studies were performed to assess the binding affinity and interactions of the designed compounds with key targets associated with anticonvulsant activity, part

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20

Thiry, Anne, Jean-Michel Dogne, Claudiu Supuran, and Bernard Masereel. "Carbonic Anhydrase Inhibitors as Anticonvulsant Agents." Current Topics in Medicinal Chemistry 7, no. 9 (2007): 855–64. http://dx.doi.org/10.2174/156802607780636726.

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21

Mullick, Pooja, Suroor A. Khan, Surajpal Verma, and Ozair Alam. "Thiadiazole Derivatives as Potential Anticonvulsant Agents." Bulletin of the Korean Chemical Society 32, no. 3 (2011): 1011–16. http://dx.doi.org/10.5012/bkcs.2011.32.3.1011.

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22

BEGUIN, C. "Functionalized amido ketones: new anticonvulsant agents." Bioorganic & Medicinal Chemistry 11, no. 19 (2003): 4275–85. http://dx.doi.org/10.1016/s0968-0896(03)00434-6.

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23

Moussa, Hind N., Alejandra Elder Ontiveros, Ziad A. Haidar, and Baha M. Sibai. "Safety of anticonvulsant agents in pregnancy." Expert Opinion on Drug Safety 14, no. 10 (2015): 1609–20. http://dx.doi.org/10.1517/14740338.2015.1085503.

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24

Baker, D. K., M. V. Relling, C. H. Pui, M. L. Christensen, W. E. Evans, and J. H. Rodman. "Increased teniposide clearance with concomitant anticonvulsant therapy." Journal of Clinical Oncology 10, no. 2 (1992): 311–15. http://dx.doi.org/10.1200/jco.1992.10.2.311.

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PURPOSE A possible pharmacokinetic interaction between teniposide and anticonvulsant medications was evaluated in pediatric patients. PATIENTS AND METHODS The systemic clearance of teniposide was determined in six pediatric patients with acute lymphocytic leukemia receiving concomitant therapy with anticonvulsants. Clearance was then compared with a control group of patients treated with the same protocol therapy and matched for age at diagnosis, sex, and race but not receiving anticonvulsants or other agents known to induce hepatic metabolism or alter protein binding of drugs. Eight blood sam

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25

Toth, Peter, and Frances R. Frankenburg. "Clozapine and Seizures: A Review." Canadian Journal of Psychiatry 39, no. 4 (1994): 236–38. http://dx.doi.org/10.1177/070674379403900409.

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Clozapine, a novel antipsychotic agent, is an alternative to standard neuroleptic therapy for psychotic disorders. Some advantages of clozapine over neuroleptics are that it may be a more effective antipsychotic in treatment resistant patients and has a lower incidence of extrapyramidal side effects. However, seizures associated with clozapine treatment occur at a rate of about three percent. Factors which seem to increase the likelihood of seizures include high doses of clozapine, rapid dose titration, the concurrent use of other epileptogenic agents and a previous history of neurological abn

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Valenta, Vladimír, Zdeněk Vejdělek, Karel Šindelář, and Miroslav Protiva. "Potential anticonvulsants: Some derivatives and analogues of 2-propylpentanoic acid." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1067–76. http://dx.doi.org/10.1135/cccc19901067.

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Reaction of 2-(ethoxycarbonylamino)ethanol with 2-propylpentanoyl chloride gave the ester III. N-(4-Piperidinyl)-2-propylpentanamide (V) was prepared via the 1-benzyl-4-piperidinyl derivative IV and was acylated with ethanesulfonyl chloride and 2-propylpentanoyl chloride to give the amides VI and VII. Malonic ester syntheses afforded diethyl 2-ethyl- and 2-propyl-2-(2-(methylthio)ethyl)malonate VIII and XIII which were hydrolyzed and decarboxylated to the acids X and XV which, in turn, were transformed to the amides XII and XVII. 3-Thiapentanenitrile was alkylated with propyl bromide to the ni

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27

Dorson, Peter G. "Psychiatric Uses of Anticonvulsants." Journal of Pharmacy Practice 3, no. 4 (1990): 262–75. http://dx.doi.org/10.1177/089719009000300408.

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Anticonvulsants are being used for psychiatric indications with increasing frequency. The potential indications for carbamazepine (CBZ), valproic acid (VPA), clonazepam, and phenytoin are reviewed, with emphasis on double-blind controlled studies where available. Dosage guidelines, adverse effects, and monitoring parameters are reviewed for each of these drugs. The pathophysiological basis for anticonvulsant effectiveness is presented for mood disorders and aggression. CBZ and VPA represent second and third line agents after traditional lithium therapy in bipolar disorder. Clonazepam may be ef

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28

Bai, Yajun, Bin Li, Jing Xie та ін. "Synthesis and Evaluation of α-Asaronol Esters with LDH and GABAA Receptor Modulation as Anticonvulsant Agents". Letters in Drug Design & Discovery 17, № 7 (2020): 891–904. http://dx.doi.org/10.2174/1570180816666191204104127.

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Background: Our previous studies showed that α-asaronol was a potential antiepileptic candidate. Here, twelve O-terminus modified ester derivatives of α-asaronol were designed, synthesized and evaluated their anticonvulsant activity. Methods: All synthetic compounds were subjected to three animal models of seizure (MES, scPTZ and sc3-MP models) combined with neurotoxicity test, as well as the LDH inhibitory test. Furthermore, GABAA Receptor modulation and pharmacokinetic evaluation of compound 4k were also performed. Results: Five compounds (4a, 4b, 4d, 4e and 4k) showed significant anticonvul

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29

ISHTIAQ, AHMAD. "Some Newer Quinazolones as Psychotropic Agents." Journal of Indian Chemical Society Vol. 65, May 1988 (1988): 362–64. https://doi.org/10.5281/zenodo.6303704.

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Department of Chemistry, Lucknow University, Lucknow-226 007 <em>Manuscript received 4 August 1984, revised 17 December 1987, accepted 22 December 1987</em> Some substituted-quinazolones have been synthesised with a view to evaluate CNS activity. The psychopharmacological screening has shown to possess anticonvulsant activity, observed against penlylenetetrazole. <em>In vivo</em> MAO inhibitory effect of these compounds were studied during oxidative deaminisation of benzylamine using rat brain homogenate,

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30

Ahsan, Mohamed. "Semicarbazone Analogs as Anticonvulsant Agents: A Review." Central Nervous System Agents in Medicinal Chemistry 13, no. 2 (2013): 148–58. http://dx.doi.org/10.2174/18715249113136660016.

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Ahsan, Waquar, Mohsin M. Safhi, Nadeem Siddiqui, et al. "An Insight into the New Anticonvulsant Agents." Current Topics in Medicinal Chemistry 12, no. 9 (2012): 1072–92. http://dx.doi.org/10.2174/156802612800229233.

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32

Jain, Jainendra, Y. Kumar, James Stables, and Reema Sinha. "Menthone Semicarbazides and Thiosemicarbazides as Anticonvulsant Agents." Medicinal Chemistry 6, no. 1 (2010): 44–50. http://dx.doi.org/10.2174/157340610791208727.

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Al-Otaibi, Faisal. "An overview of structurally diversified anticonvulsant agents." Acta Pharmaceutica 69, no. 3 (2019): 321–44. http://dx.doi.org/10.2478/acph-2019-0023.

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Abstract There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thi

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Pandey, Sh, Sh Shukla, D. Pandey, and R. S. Srivastava. "Studies on anticonvulsant agents. Achievements and prospects." Russian Chemical Reviews 80, no. 2 (2011): 187–96. http://dx.doi.org/10.1070/rc2011v080n02abeh004185.

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Zayed, Mohamed F. "New fluorinated quinazolinone derivatives as anticonvulsant agents." Journal of Taibah University Medical Sciences 9, no. 2 (2014): 104–9. http://dx.doi.org/10.1016/j.jtumed.2013.11.009.

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Pavia, Michael R., Sandra J. Lobbestael, Charles P. Taylor, Fred M. Hershenson, and David L. Miskell. "N-Phenyl-N'-pyridinylureas as anticonvulsant agents." Journal of Medicinal Chemistry 33, no. 2 (1990): 854–61. http://dx.doi.org/10.1021/jm00164a061.

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Pavia, Michael R., Charles P. Taylor, Fred M. Hershenson, Sandra J. Lobbestael, and Donald E. Butler. "3-Phenoxypyridine 1-oxides as anticonvulsant agents." Journal of Medicinal Chemistry 31, no. 4 (1988): 841–47. http://dx.doi.org/10.1021/jm00399a027.

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Zayed, M., and R. Ayyad. "Some Novel Anticonvulsant Agents Derived from Phthalazinedione." Arzneimittelforschung 62, no. 11 (2012): 532–36. http://dx.doi.org/10.1055/s-0032-1323758.

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Ugale, Vinod G., Harun M. Patel, Sudhir G. Wadodkar, Sanjay B. Bari, Atul A. Shirkhedkar, and Sanjay J. Surana. "Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents." European Journal of Medicinal Chemistry 53 (July 2012): 107–13. http://dx.doi.org/10.1016/j.ejmech.2012.03.045.

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40

Cristóbal-Luna, José Melesio, María Angélica Mojica-Villegas, Sergio Enrique Meza-Toledo, Yuliana García-Martínez, Angélica Pérez-Juárez, and Germán Chamorro-Cevallos. "Developmental Toxicity Study of DL-4-Hydroxy-4-Phenylhexanamide (DL-HEPB) in Rats." Life 13, no. 8 (2023): 1714. http://dx.doi.org/10.3390/life13081714.

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Antiepileptic drugs affect embryonic development when administered during pregnancy, generating severe alterations, such as as cleft lip, spina bifida, heart abnormalities, or neuronal alterations. The compound DL-4-hydroxy-4-phenylhexanamide (DL-HEPB), a phenyl alcohol amide structurally different from known anticonvulsants, has shown good anticonvulsant effects in previous studies. However, its effects on intrauterine development are unknown. So, the purpose of this study was to determine the potential of DL-HEPB to produce alterations in conceptus. Pregnant Wistar rats were orally exposed t

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Alswah, Mohamed, Adel Ghiaty, Ahmed El-Morsy, and Kamal El-Gamal. "Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents." ISRN Organic Chemistry 2013 (September 12, 2013): 1–7. http://dx.doi.org/10.1155/2013/587054.

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2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.

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Aragade, Prashant, Sadhana Kolhe, Hemant Kamble, Dwarkadas Baheti, and Veeresh Maddi. "Synthesis and Preliminary Evaluation of Some Substituted Pyrazoles as Anticonvulsant Agents." International Journal of Drug Design and Discovery 3, no. 1 (2025): 688–93. https://doi.org/10.37285/ijddd.3.1.3.

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A series of 3-[3-(substituted phenyl)-1-isonicotinoyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives (4a-k) were synthesized using appropriate synthetic route and characterized by spectral data. The anticonvulsant activity of the synthesized compounds were evaluated against seizure induced by strychnine in mice. All the test compounds were administered at doses of 100 mg/kg body weight. Three compounds of the series, 4b, 4j and 4k exhibited significant anticonvulsant activity comparable to standard drug,phenytoin

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B, Ravindar, Srinivasa Murthy M, and Afzal Basha Shaik. "DESIGN, FACILE SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL 1,3-THIAZINE DERIVATIVES AS POTENTIAL ANTICONVULSANT AGENTS." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 272. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13676.

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ABSTRACTObjective: Chalcones and their heterocyclic analogs represent an important class of small molecules having anticonvulsant activities. Therefore, inthis study, the synthesis and anticonvulsant activity of some new chalcones and 1,3-thiazines were described.Methods: The reaction of 1-acetylnaphthalene with substituted aromatic aldehydes in the presence of aq. NaOH afforded corresponding chalconeswhich upon further cyclization with thiourea resulted in 1,3-thiazine derivatives. The newly synthesized compounds were tested for anticonvulsantactivity by pentylenetetrazole-induced seizures me

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Tsyvunin, Vadim, Sergiy Shtrygol’, Ihnat Havrylov, and Diana Shtrygol’. "Low-dose digoxin enhances the anticonvulsive potential of carbamazepine and lamotrigine in chemo-induced seizures with different neurochemical mechanisms." ScienceRise: Pharmaceutical Science, no. 6 (34) (December 13, 2021): 58–65. http://dx.doi.org/10.15587/2519-4852.2021.249375.

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"Non-antiepileptic" drugs have a strong potential as adjuvants in multidrug-resistant epilepsy treatment. In previous study the influence of low doses of digoxin, which do not affect the myocardium, on the anticonvulsant potential of classical commonly used anti-epileptic drugs under conditions of seizures, induced by pentylenetetrazole and maximal electroshock, has been investigated. The aim of the study was to investigate the influence of digoxin at a sub-cardiotonic dose on the anticonvulsant potential of carbamazepine and lamotrigine in experimental seizures with different neurochemi

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Noviasky, John A., Anton P. Porsteinsson, and Yeong H. Lee. "Second Generation Anticonvulsant Medications: Their Use in Children." Journal of School Nursing 17, no. 2 (2001): 103–11. http://dx.doi.org/10.1177/105984050101700208.

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The pharmacotherapy of seizure disorders has long relied on a few standard medications such as phenobarbital, phenytoin (Dilantin), valproate (Depakote), and others that represent the “first generation” of anticonvulsants. This article reviews the newer, “second-generation” anticonvulsants that were developed in the last decade. The addition of these second-generation agents has doubled the number of therapies available for the treatment of seizure disorders. They include felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), ti

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Church, John, Martyn G. Jones, Stephen N. Davies, and David Lodge. "Antitussive agents as N-methylaspartate antagonists: further studies." Canadian Journal of Physiology and Pharmacology 67, no. 6 (1989): 561–67. http://dx.doi.org/10.1139/y89-090.

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The relative potencies of ketamine and the morphinan derivatives dextrorphan, dextromethorphan, and levorphanol as antagonists of the excitatory actions of N-methylaspartate on rat spinal neurones in vivo were examined, both following their microelectrophoretic administration and, with the exception of levorphanol, after intravenous injection. Applied microelectro-phoretically, dextrorphan was a more potent N-methylaspartate antagonist than ketamine, levorphanol, or dextromethorphan. After systemic administration, however, dextrorphan was rather less potent than ketamine in this respect, where

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Abida, Md Tauquir Alam, and Mohammad Asif. "Study of Some Hyndantion Derivatives as Anticonvulsant Agents." Progress in Chemical and Biochemical Research 3, no. 2 (2020): 93–104. http://dx.doi.org/10.33945/sami/pcbr.2020.2.2.

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López-Muñoz, Francisco. "Anticonvulsant Agents for the Management of Benzodiazepine Dependence." Addiction & Addictive Disorders 1 (September 30, 2014): 1–10. http://dx.doi.org/10.24966/aad-7276/100003.

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Yogeeswari, P., D. Sriram, V. Veena, et al. "Synthesis of aryl semicarbazones as potential anticonvulsant agents." Biomedicine & Pharmacotherapy 59, no. 1-2 (2005): 51–55. http://dx.doi.org/10.1016/j.biopha.2004.04.013.

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Rivara, Mirko, and Valentina Zuliani. "In vivo screening of diarylimidazoles as anticonvulsant agents." Medicinal Chemistry Research 21, no. 11 (2011): 3428–34. http://dx.doi.org/10.1007/s00044-011-9869-9.

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