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Journal articles on the topic 'Antidementia medications'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

He, Meiqi, James M. Stevenson, Yuting Zhang, and Inmaculada Hernandez. "Risk Factors for Cardiovascular Events in Patients on Antidementia Medications." American Journal of Alzheimer's Disease & Other Dementiasr 35 (January 1, 2020): 153331752092238. http://dx.doi.org/10.1177/1533317520922380.

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Objective: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. Methods: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events. Results: Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381

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2

Handa, Nobuhiro, Seigo Mitsutake, Tatsuro Ishizaki, et al. "Associations of coprescribed medications for chronic comorbid conditions in very old adults with clinical dementia: a retrospective cohort study using insurance claims data." BMJ Open 11, no. 7 (2021): e043768. http://dx.doi.org/10.1136/bmjopen-2020-043768.

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ObjectiveTo assess the association of coprescribed medications for chronic comorbid conditions with clinical dementia in older adults, as indicated by the initiation of a new prescription of antidementia medication (NPADM).DesignRetrospective enumeration cohort study.SettingA Japanese city in Tokyo Metropolitan Area.ParticipantsA total of 42 024 adults aged ≥77 years residing in Kashiwa City, a suburban city of Tokyo Metropolitan Area, who did not have any prscription of antidementia medication from 1 April to 30 June 2012.Main outcome measureThe primary outcome was NPADM during follow-up peri

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Singh, Rakesh R., and Rajesh Nayak. "Impact of FDA Black Box Warning on Psychotropic Drug Use in Noninstitutionalized Elderly Patients Diagnosed With Dementia." Journal of Pharmacy Practice 29, no. 5 (2016): 495–502. http://dx.doi.org/10.1177/0897190015579451.

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Background: The study seeks to investigate the impact of Food and Drug Administration's black box warning (BBW) on the use of atypical antipsychotics (AAP) and nonantipsychotic psychotropic alternatives in noninstitutionalized elderly population diagnosed with dementia. Method: The Medical Expenditure Panel Survey (2004 through 2007) was utilized as the data source. Medication use in elderly patients (≥65 years) was defined as taking at least 1 medication for dementia. We performed a statistical comparison of prewarning (2004-2005) and postwarning (2006-2007) periods with respect to AAP and no

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Zhong, Wenjun, Xinyue Liu, Tiffini Voss, et al. "Medications in Patients with Dementia and Behavioral Disturbance." Journal of Alzheimer's Disease Reports 5, no. 1 (2021): 535–40. http://dx.doi.org/10.3233/adr-210023.

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Background: Behavioral disturbance (BD) is common in dementia patients, with no FDA approved medications for this condition. Little data exists on the real-world medication use in this population. Objective: To describe real-world medications use in this population. Methods: A cross-sectional study was conducted using the MarketScan database for outpatient medications and the Cerner database for inpatient medications. The study period was Oct 2015–Jun 2018. Patients with dementia and BD were identified through ICD-10-CM. We examined outpatient medications prescribed during 6-month before or af

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de Mendonça Lima, C. A. "Drug Interactions with Antidementia Drugs: Clinical Consequences." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70476-6.

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Alzheimer" disease (AD) is a major public health problem, and it is at the origin of a significant burden: 15% of direct costs in dementia are attributed to pharmacological treatment. Persons with dementia often have comorbidities and receive multiple medications. Both factors increase the risk of drug-drug interactions (DDIs) which can result in adverse drug reactions (ADRs). In a study, a total of 1058 spontaneous reports were identified that involved cholinesterase inhibitors (ChEIs) in the French Pharmacovigilance Database; 35.5% contained at least one DDI; 118 of them (31.4%) were the cau

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Na, Hae Ri, Seong-Hye Choi, Kyung Won Park, Yun Jeong Hong, Jee Hyang Jeong, and Eunjoo Kim. "P3-313: Discontinuation of antidementia medications in extremely severe Alzheimer's disease patients: A 12-week, randomized, multicenter trial." Alzheimer's & Dementia 11, no. 7S_Part_16 (2015): P757. http://dx.doi.org/10.1016/j.jalz.2015.06.1687.

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7

Ofori-Asenso, Richard, Jenni Ilomaki, Mark Tacey, et al. "Prevalence and Incidence of Statin Use and 3-Year Adherence and Discontinuation Rates Among Older Adults With Dementia." American Journal of Alzheimer's Disease & Other Dementiasr 33, no. 8 (2018): 527–34. http://dx.doi.org/10.1177/1533317518787314.

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Objective: To examine the patterns of statin use and determine the 3-year adherence and discontinuation rates among a cohort of Australians aged ≥65 years with dementia. Methods: The yearly prevalence and incidence of statin use were compared via Poisson regression modeling using 2007 as the reference year. People with dementia were identified according to dispensing of antidementia medications. A cohort of 589 new statin users was followed longitudinally. Adherence was estimated via the proportion of days covered (PDC). Discontinuation was defined as ≥90 days without statin coverage. Results:

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Bhor, Rohit Jaysing. "A REVIEW ON “NEW TREATMENT STRATEGIES FOR ALZHEIMER’S DISEASE AS NEURODEGENERATIVE DISEASE AND ITS RISK FACTOR CAUSE, SYMPTOMS, AND TREATMENT AT WORLDWIDE”." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 16. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14196.

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ABSTRACTAlzheimer’s disease (AD) is a dynamic and irreversible neurodegenerative illness and relates to the most widely recognized reason for dementiaaround the world. AD is a dynamic and lethal cerebrum ailment. Alzheimer’s obliterates mind cells, bringing on memory issue or misfortune and issueswith speculation and conduct sufficiently serious to influence work, long lasting leisure activities or social life. Alzheimer’s illness is quickly becomingworldwide, but there is no cure for it. Now, accessible medications just give symptomatic help and do not mediate in infection prepare adequatelye

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9

Khovasova, N. O., A. V. Naumov, O. N. Tkacheva, E. N. Dudinskaya, and V. I. Moroz. "Polypharmacy in elderly patients with falls." Osteoporosis and Bone Diseases 24, no. 1 (2021): 10–18. http://dx.doi.org/10.14341/osteo12716.

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Background: Falls in elderly–a multifactorial syndrome. One of the modifiable factors is polypharmacy. STOPP/START criteria are used for correction of polypharmacy in geriatrics.Aim: Assessment of the prevalence of polypharmacy, analysis and correction of pharmacotherapy using STOPP/START criteria in patients with falls.Materials and methods: The study included 655 patients hospitalized in the geriatric department over 60 years of age, who were divided into two groups. Group 1 (n=332, 50.7%)–patients with 1 or more falls, group 2 (n=323,49.3%)–patients without falls. The analysis of the receiv

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Oderda, Lynda, Christine Holman, Ben Nichols, et al. "Pharmacist-Managed Telephone Clinic Review of Antidementia Medication Effectiveness." Consultant Pharmacist 26, no. 4 (2011): 264–73. http://dx.doi.org/10.4140/tcp.n.2011.264.

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11

Lind, Kimberly E., Leonard C. Gray, Magdalena Z. Raban, Andrew Georgiou, and Johanna I. Westbrook. "Antidementia medication use by aged care facility residents with dementia." International Journal of Geriatric Psychiatry 34, no. 7 (2019): 1029–40. http://dx.doi.org/10.1002/gps.5105.

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12

Westendorf, J., R. Diebow, M. Kieser, and W. Gaus. "Identification of Adverse Drug Reactions by Evaluation of a Prescription Database, Demonstrated for “Risk of Bleeding”." Methods of Information in Medicine 44, no. 05 (2005): 697–703. http://dx.doi.org/10.1055/s-0038-1634027.

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Summary Objective: Information about adverse drug reactions plays an important role when assessing the benefit/risk profile of a drug. Identifying rare adverse drug reactions, however, is a difficult task. This paper illustrates the advantages of using a prescription database for this purpose. Methods: The mediplus® database used in our analysis covered data from 320,644 outpatients observed between July 1999 and June 2002. The example of bleeding complications during intake of antidementia drugs is used to illustrate this approach. The comparison of cohorts and subgroups is nearly always a pr

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13

Lind, Kimberly E., Kerry Hildreth, Richard Lindrooth, Elaine Morrato, Lori A. Crane, and Marcelo Coca Perraillon. "Effect of Medicare Part D on Ethnoracial Disparities in Antidementia Medication Use." Journal of the American Geriatrics Society 66, no. 9 (2018): 1760–67. http://dx.doi.org/10.1111/jgs.15494.

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14

Behrens, S., R. B. Gail, S. De Berard, et al. "ANTIDEMENTIA MEDICATION USE IS ASSOCIATED WITH DECREASED INFORMAL COSTS IN MILD DEMENTIA." Innovation in Aging 1, suppl_1 (2017): 900. http://dx.doi.org/10.1093/geroni/igx004.3228.

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15

Bohlken, Jens, Simon Weber, Michael A. Rapp, and Karel Kostev. "Continuous treatment with antidementia drugs in Germany 2003–2013: a retrospective database analysis." International Psychogeriatrics 27, no. 8 (2015): 1335–42. http://dx.doi.org/10.1017/s1041610215000654.

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ABSTRACTBackground:Continuous treatment is an important indicator of medication adherence in dementia. However, long-term studies in larger clinical settings are lacking, and little is known about moderating effects of patient and service characteristics.Methods:Data from 12,910 outpatients with dementia (mean age 79.2 years; SD = 7.6 years) treated between January 2003 and December 2013 in Germany were included. Continuous treatment was analysed using Kaplan–Meier curves and log-rank tests. In addition, multivariate Cox regression models were fitted with continuous treatment as dependent vari

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16

Simpson, Steve, Diane Beavis, Adrian Leddy, Sue Ball, and Ian Johnson. "Naturalistic audit of NICE criteria for the use of cholinesterase inhibitors." Psychiatric Bulletin 29, no. 11 (2005): 410–12. http://dx.doi.org/10.1192/pb.29.11.410.

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Aims and MethodIn 2001 the National Institute for Clinical Excellence (NICE) produced guidance for the treatment of Alzheimer's disease. NICE encourages the withdrawal of medication when the Mini-Mental State Examination (MMSE) score reaches 12 and advises against the treatment of patients with cholinesterase inhibitors if the MMSE score is below 12. Most health authorities have rigorously enforced these guidelines, which has put old age psychiatrists in a difficult position. Our prospective 12 week audit of consecutive patients examines the response to treatment of patients treated both in ac

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17

Lundby, Carina, John Jensen, Søren Post Larsen, Helene Hoffmann, Anton Pottegård, and Mette Reilev. "Use of medication among nursing home residents: a Danish drug utilisation study." Age and Ageing 49, no. 5 (2020): 814–20. http://dx.doi.org/10.1093/ageing/afaa029.

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Abstract Background Data on drug utilisation patterns in nursing home populations is scarce. We aimed to describe drug use patterns in Danish nursing home residents. Methods We established a cohort of 5,179 individuals (63% women; median age of 84 years) admitted into 94 nursing homes across Denmark during 2015–2017. Data on prescription drug use and other census data were obtained from the nationwide Danish health registries. Results The total number of drug classes filled increased from a median of 6 drugs (interquartile range [IQR] 3–9) at 18–24 months before nursing home admission to a med

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18

Lampela, Pasi, Anna-Maija Tolppanen, Marjaana Koponen, et al. "Asthma and Chronic Obstructive Pulmonary Disease as a Comorbidity and Association with the Choice of Antidementia Medication Among Persons with Alzheimer’s Disease." Journal of Alzheimer's Disease 73, no. 3 (2020): 1243–51. http://dx.doi.org/10.3233/jad-190850.

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19

Terzi, Handan, and Yeter Kitiş. "Conformity assessment of drugs used by the elderly in terms of the beers criteria." International Journal Of Community Medicine And Public Health 4, no. 2 (2017): 370. http://dx.doi.org/10.18203/2394-6040.ijcmph20170257.

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Background: The risk of drug-drug interactions is more probable among the elderly population than that of the young patients, and this emerges as a potentially vital issue. Therefore, this survey aims to describe the conformity assessment of drugs used by the elderly in terms of The Beers Criteria.Methods:This descriptive study was conducted at two different nursing-homes with 301 seniors. The-AGS-2012-Beers-Criteria-List and a questionnaire, assessing the socio-demographic characteristics and the health-condition/illness-history of the elderly, were used in collecting the data. The data were

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20

Sicras, A., J. Vergara, T. León, L. Febrer, and J. Rejas. "PNL3 RETROSPECTIVE COMPARATIVE ANALYSIS OF ANTIDEMENTIA MEDICATION PERSISTENCE PATTERNS AT 3 YEARS IN SPANISH ALZHEIMER DISEASE PATIENTS TREATED WITH DONEPEZIL, RIVASTIGMINE, GALANTAMINE AND MEMANTINE." Value in Health 8, no. 6 (2005): A129. http://dx.doi.org/10.1016/s1098-3015(10)67542-0.

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21

Popoola, Abraham, Maria O'Donovan, and Eleanor Mullan. "An assessment of the new memory clinic at Cork University Hospital." Irish Journal of Psychological Medicine 25, no. 2 (2008): 61–65. http://dx.doi.org/10.1017/s079096670001096x.

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AbstractObjective: Dementia is a progressive brain disease. The prevalence of dementia increases with age. Symptomatic pharmacological treatments for dementia are available. Psychological and social interventions can support the patient and their carer. Early recognition and diagnosis of dementia are necessary to access this care and reduce crisis-led intervention. A memory clinic service is ideally placed to commence the assessment and management of dementia. The objective of this paper was to describe the setting up of the memory clinic in Cork University Hospital and review the characterist

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Banerjee, S., J. Hellier, R. Romeo, et al. "Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine." Health Technology Assessment 17, no. 7 (2013): 1–166. http://dx.doi.org/10.3310/hta17070.

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ObjectiveDepression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.DesignMulticentre, parallel-group, double-blind placebo-controlled randomised controlled trial of the clinical effectiveness of sertraline and mirtazapine with 13- and 39-week follow-up.SettingNine English old-age psychiatry services.ParticipantsA pragmatic tr

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23

Nåvik, Marit, Knut Engedal, and Ingun Ulstein. "Register til nytte eller besvær, hva vet vi etter fem år? Etablering av et kvalitets- og forskningsregister for hukommelsesklinikker i spesialisthelsetjenesten." Nordisk tidsskrift for helseforskning 9, no. 2 (2014): 92. http://dx.doi.org/10.7557/14.2823.

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<p><strong>Patient Registry, useful or not? What have we learned after five years?<em><br />Background and aims</em></strong><strong><em>: </em></strong><em>A patient registry was established in January 2009 to improve the quality of assessment and treatment of dementia at memory clinics in the South-Eastern and Western Health Regions of Norway. Further aims were to examine the validity of cognitive tests used in the assessment of dementia, to obtain new knowledge about risk factors and the course of dementia, treatment with and

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Chulakadabba, Kritapas, Weerasak Muangpaisan, Pitiporn Siritipakorn, et al. "Characteristics and Real-Life Outcomes of Dementia and Cognitive Impairment at a Geriatric Clinic." Dementia and Geriatric Cognitive Disorders 49, no. 3 (2020): 312–20. http://dx.doi.org/10.1159/000509731.

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<b><i>Background:</i></b> Various patterns of dementia care have been developed in different settings, depending on the availability of healthcare resources and facilities. The purpose of this study was to examine the epidemiology and characteristics of dementia care at a geriatric clinic, a field that has been subject to little prior evaluation. <b><i>Methods:</i></b> A retrospective chart review was undertaken of cohort patients with cognitive impairment who had received a diagnosis and were still on active follow-up at a geriatric clinic. A to

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Xu, Lu, Xiaozhen Lv, Huali Wang, et al. "Trends in Psychotropic Medication Prescriptions in Urban China From 2013 to 2017: National Population-Based Study." Frontiers in Psychiatry 12 (August 25, 2021). http://dx.doi.org/10.3389/fpsyt.2021.727453.

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Purpose: Psychotropic medications are commonly used for treating mental disorders; however, there is currently no study on how commonly they are used in China. This study reported the trends in psychotropic medications prescriptions in urban China.Methods: A national population-based study was conducted using the China Health Insurance Research Association database to estimate the period prescription prevalence of 11 major classes of psychotropic medications annually during 2013–2017. The World Health Organization Anatomical Therapeutic Chemical (ATC) classification codes were used to identify

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Levine, Stephen Z., Yair Goldberg, Kazufumi Yoshida, et al. "Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil." European Psychiatry 64, no. 1 (2021). http://dx.doi.org/10.1192/j.eurpsy.2021.8.

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Abstract Background The extent and profiles of heterogeneity in cognitive functioning among participants in clinical trials of antidementia medication are unknown. We aimed to quantify and identify profiles of heterogeneity of cognition in Alzheimer’s disease. Methods Individual-level participant data were analyzed from five pivotal clinical trials of donepezil for Alzheimer’s disease (N = 2,919). Based on Alzheimer’s Disease Assessment Scale–Cognitive Subscale total scores from baseline up to week 12, a latent class model was used to identify heterogeneous groups. A logistic regression model

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27

Oh, S. T., K. T. Han, W. J. Choi, and J. Park. "Effect of drug compliance on health care costs in newly-diagnosed dementia: a nation-wide analysis." European Journal of Public Health 29, Supplement_4 (2019). http://dx.doi.org/10.1093/eurpub/ckz187.216.

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Abstract Background The cost-effectiveness of both cholinesterase inhibitors and memantine by delaying nursing home placement has been supported by numerous studies. The importance of sustained pharmacological treatment in dementia has been relatively less recognized by public health policies compared to early diagnosis. We investigated the effect of the drug (donepezil, rivastigmine, galantamine, and memantine) compliance on the health care costs in newly-diagnosed dementia. Methods National Health Insurance Service (NHIS) database which covers the entire population of South Korea was used fo

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