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Dissertations / Theses on the topic 'Antidiabetic and anti-inflammatory drugs'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Hashim, Hadida. "Transdermal delivery of anti-inflammatory drugs." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254952.

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2

Ingram, Matthew John. "Nitroxylated non-steroidal anti-inflammatory drugs." Thesis, Liverpool John Moores University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400526.

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3

Layne, Kerry Anne. "Anti-inflammatory effects of anti-platelet drugs : implications for atherosclerosis." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/antiinflammatory-effects-of-antiplatelet-drugs(1da58105-e415-4241-a696-effb35badd21).html.

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Cardiovascular disease secondary to atherosclerosis is the leading cause of death worldwide. The pathophysiology of atherosclerosis is multifactorial and complex. This thesis offers insight into the regulation of several potential biomarkers of cardiovascular disease and explores the effects of anti-platelet therapy in modulating these pathways. CD14highCD16+ monocytes are elevated in patients with atherosclerosis and may be predictive of future cardiovascular events. The initial study in this PhD project assessed the effects of anti-platelet drugs on the phenotype of circulating monocytes in

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4

Butler, Gregory James. "Non-steroidal anti-inflammatory drugs and skin cancer /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19122.pdf.

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5

Campbell, William I. "Pain suppression using non-steroidal anti-inflammatory drugs." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335935.

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6

Walley, Matthew John Mervyn. "Methods of toxicity of nonsteroidal anti-inflammatory drugs." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405826.

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7

Duffy, Judith Clare. "Design of novel non-steroidal anti-inflammatory drugs." Thesis, Liverpool John Moores University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521744.

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8

Chan, Sui Yung. "Transdermal delivery of anti-inflammatory agents." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334523.

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9

Coste, Emmanuel. "Development of small molecules as anti-inflammatory and anti-resorptive drugs." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/9941.

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Rheumatoid arthritis is an auto-immune inflammatory disease that leads to stiff and swollen joints. Patients also have severe bone destruction of the affected joints and another common symptom of rheumatoid arthritis is a generalised bone loss that can lead to osteoporosis. Currently, there are many treatments for rheumatoid arthritis, which provide a recession of the inflammatory symptoms. However, none of these treatments are able to provide a complete protection against the rheumatoid arthritis-induced bone loss. Furthermore, the most effective available treatments such as glucocorticoids o

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10

Gregg, Catherine Nicola. "Structure-activity studies in non-steroidal anti-inflammatory drugs." Thesis, Liverpool John Moores University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238686.

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11

Moin, Mahera. "Synthesis of curcuminoids as non-steroidal anti-inflammatory drugs." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20760/.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely prescribed therapeutic agents used worldwide, to treat various inflammatory diseases. However, these drugs do not solve the underlying problem of inflammation and their long-term administration is associated with serious gastrointestinal complications, such as gastric ulcers and bleeding. Curcumin 1, (figure A) the diferuloylmethane, a yellow pigment found in the rhizomes of turmeric (Curcuma longa) possesses a well established role as an anti-inflammatory agent since ancient times to treat various inflammatory diseases. Thiophe

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12

Hammouda, Ahmed N. H. "Development of copper peptide complexes as anti-Inflammatory drugs." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15744.

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Copper complexes have been reported to have anti-inflammatory activities for the alleviation of inflammation associated with rheumatoid arthritis (RA). The present study focuses on the design of new drugs that could be used to change the bioavailability of copper and hence alleviate inflammation. The ligands chosen were sarcosyl-L-histidyl-L-lysine, sarcosyl-Llysyl- L-histidine, sarcosyl-L-histidyl-L-histidine, sarcosyl-L-lysyl-L-lysine and sarcosyl-Lglycyl- L-histidine. Equilibrium constants of H+, Cu(II), Ni(II) and Zn(II) with the peptides were measured in aqueous solution at 25±0.01oC and

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13

Mohajane, Mamohale. "Development of copper based anti-inflammatory drugs: histodine derivatives." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/6339.

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Methyliminodiacetylhistidine dimethyl ester could not be synthesised. However the other two ligands, glycine and glycyl-L-histidine were purchased and used for this study. The equilibrium constants of the ligand (glycyl-L-histidine) and the ligand complexes with Cu(II), Ni(II) and Zn(II) were investigated with glass electrode potentiometry and isothermal titration calorimetry at 25Â±0.01oC at an ionic strength 0.15M with NaCl. Potentiometric studies show that glycyl-L-histidine has three dissociable protons, and the neutral form of the ligand forms around pH 6.60. Potentiometric results of cop

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14

McKellar, Quintin Archibald. "Pharmacokinetics and pharmacodynamics of anti-infective and anti-inflammatory drugs in animals." Thesis, University of Glasgow, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395088.

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15

Kent, Lauren Marie. "Assessment of anti-inflammatory drugs in COPD using macrophage models." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514433.

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16

Gu, Qing. "Helicobacter pylori and non-steroidal anti-inflammatory drugs in gastric carcinogenesis." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36589718.

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17

St, Germaine Christine. "Genetic polymorphisms and the cardiovascular risk of nonsteroidal anti-inflammatory drugs." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19240.

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The cardiovascular safety of cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drugs (NSAIDs) is of concern, although the majority of users remain free of adverse outcomes. A gene-drug interaction may contribute to the variation in individual response to NSAIDs. In a case-only study of 460 patients selected from a cohort admitted for an acute coronary syndrome we genotyped 115 single nucleotide polymorphisms (SNPs). We observed statistically significant gene-drug interactions between NSAID exposure and 16

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18

Lipscomb, George Robert. "Gastric mucosal adaption to non-steroidal anti-inflammatory drugs in man." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362744.

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19

Gu, Qing, and 谷青. "Helicobacter pylori and non-steroidal anti-inflammatory drugs in gastric carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36589718.

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20

Heasman, P. A. "The effects of non-steroidal anti-inflammatory drugs on peridontal disease." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335228.

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21

Garth-Greeves, Alix. "The detection of non-steroidal anti-inflammatory drugs in keratinous matrices." Thesis, Anglia Ruskin University, 2016. http://arro.anglia.ac.uk/701347/.

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The problems of non-steroidal anti-inflammatory drugs (NSAIDs) as environmental contaminants is an area of concern. NSAIDs are heavily relied upon to treat pain and inflammation. With such prevalence, these compounds are now entering the environment via many routes, such as water discharge and contaminated food. This results in subsequent exposure and effects on various animal species. One such example is diclofenac, which was associated with the extinction of Gyps vultures in Asia. The detection of diclofenac was based on post-mortem samples i.e. after a large decline in populations. In this

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22

Abaniwonda, Modupe. "Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs." University of the Western Cape, 2017. http://hdl.handle.net/11394/5693.

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Magister Pharmaceuticae - MPharm<br>Recent scientific findings have highlighted the beneficial roles of polycyclic cage compounds in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Further interest into the chemistry of these compounds is stimulated by their remarkable ability to improve the pharmacokinetics profile of known neuroprotective agents. As potent lipophilic scaffolds, they can be employed to target the brain delivery of desired compounds. Inflammation is a key mediator of neuronal cell's degeneration as activated microglia and other inflammatory mediators

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23

Garth-Greeves, Alix. "The detection of non-steroidal anti-inflammatory drugs in keratinous matrices." Thesis, Anglia Ruskin University, 2016. https://arro.anglia.ac.uk/id/eprint/701347/1/Garth-Greeves_2016.pdf.

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The problems of non-steroidal anti-inflammatory drugs (NSAIDs) as environmental contaminants is an area of concern. NSAIDs are heavily relied upon to treat pain and inflammation. With such prevalence, these compounds are now entering the environment via many routes, such as water discharge and contaminated food. This results in subsequent exposure and effects on various animal species. One such example is diclofenac, which was associated with the extinction of Gyps vultures in Asia. The detection of diclofenac was based on post-mortem samples i.e. after a large decline in populations. In this

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24

Elmagbari, Fatin M. Ali. "Synthesis and design of ligand copper complexes as anti-inflammatory drugs." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15767.

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Rheumatoid arthritis is a debilitating disease for which there is no cure. Copper has been used for centuries to alleviate the inflammation associated with the disease. The aim of this research was to design and test new ligands which are able to promote the percutaneous absorption of copper and/or mobilize endogenous copper reserves. Formation constants of H+, Cu(II), Ni(II) and Zn(II) with five low molecular ligands 2-((2-aminoethyl)amino)-N-(pyridin-2- ylmethyl)acetamide) [H(555)NH2], 2-((2-dimethyl-amino)ethyl)amino)-N-(pyridin-2-ylmethyl) acetamide [H(555)NMe2], N-(2-aminoethyl)-N'-(pyrid

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25

Griesbach, Robert Christian. "Approaches to the asymmetric synthesis of non-steroidal anti-inflammatory drugs /." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phg848.pdf.

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26

PIREDDU, ROSA. "Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266618.

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The purpose of the present PhD thesis was to study two different nanosized systems, liposomes and nanosuspensions. Liposomes were develop with the aim to improve the Triiodothyronine (T3) delivery to hepatic cancer cells and nanosuspensions were proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal anti-inflammatory drug (NSAID) with a very low aqueous solubility. T3, is a thyroid hormone normally synthesized and secreted by the thyroid gland and through interaction with its nuclear receptors (TRs) plays an essential role in morphogenesis and differentiation. How

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27

Chak, Man-lee Charlotta. "A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-induced gastrointestinal effects." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971453.

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28

Gupta, Paul. "The control of intracellular calcium homeostasis by aspirin-like drugs and its relationship to mediator function." Thesis, University of Sunderland, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237813.

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29

Lewis, Edward Jonathan. "Acute phase reactants and experimental inflamation." Thesis, University of Hertfordshire, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332292.

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30

Deakin, Angela Maureen. "Modulation of cytokine release from monocytes, macrophages and cartilage." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244250.

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31

Dixey, Jeremy John. "The renal actions and interactions of nonsteroidal anti-inflammatory drugs in man." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47032.

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32

Bandara, Bandarage Mahesh Kithsiri Optometry &amp Vision Science Faculty of Science UNSW. "Investigation and characterisation of antibacterial properties of non-steroidal anti-inflammatory drugs." Awarded by:University of New South Wales. School of Optometry and Vision Science, 2005. http://handle.unsw.edu.au/1959.4/22284.

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Microbial contamination of contact lenses is a significant risk factor leading to adverse responses. Adhesion of microorganisms to a contact lens is the first step in a series of events that leads to contact lens-related infections or inflammation. Recently, some of the non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to have the ability to interfere with microbial biofilm formation. In this project, antibacterial properties of commonly used NSAIDs (salicylic acid, sodium diclofenac and ketorolac) were assessed and characterised using biological assays and molecular biological te

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33

Khazaeinia, Tahereh. "Local and systemic gastrointestinal side effects of nonsteroidal anti-inflammatory drugs, NSAIDs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0014/NQ59980.pdf.

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34

Dunagan, Fiona M. "Non-steroidal anti-inflammatory drugs : pharmacokinetics and clinical response in rheumatoid arthritis." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236497.

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35

Kooloobandi, Azam. "The microbial transformation of 2-arylpropionic acids non-steroidal anti-inflammatory drugs." Thesis, University of Brighton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314804.

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36

Elliott, Christopher S. "The Chemoprevention of Lung Cancer Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1041537546.

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37

Duong, Thi Thanh Mai. "Cardiovascular risk associated with otc-strenght nonsteroidal anti-inflammatory drugs and paracetamol." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0202/document.

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Contexte : Il y a très peu de données sur l’utilisation et la sécurité CV du paracétamol et des AINS à faible dose en l’automédication. Objectifs : établir les caractéristiques des utilisateurs, évaluer et comparer le risque de syndrome coronarien aigu (SCA), associé au paracétamol (P) et à l'ibuprofène à dose antalgique (IDA). Méthodes : Études d'utilisation, études de cohorte auto-contrôlées (self-controlled cohort - SCC), étude de cohorte appariée sur le score de propension et étude cas-témoin nichée (CTN) ont été réalisé dans l’Echantillon Généraliste Bénéficiaires (EGB) en incluant les ép

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38

Powell, Sarah Llawena. "Synthesis and reactivity of some novel prodrugs of anti-inflammatory agents." Thesis, University of Essex, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341269.

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39

Maiden, Laurence Peter. "Gastrointestinal inflammation : non steroidal anti-inflammatory drugs and inflammatory bowel disease; novel evaluation and treatment of disease." Thesis, King's College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497608.

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40

Chak, Man-lee Charlotta, and 翟敏莉. "A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-inducedgastrointestinal effects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971453.

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41

Zhu, Genghui. "Nonsteroidal antiinflammatory drugs and apoptosis of human gastric epithelial cells /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20471361.

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42

Natekar, Deepali Narayan Johnston Thomas P. "Preparation and characterization of binary solid dispersions of non-steroidal anti-inflammatory drugs." Diss., UMK access, 2007.

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Thesis (M.S.)--School of Pharmacy. University of Missouri--Kansas City, 2007.<br>"A thesis in pharmaceutical sciences." Typescript. Advisor: Thomas P. Johnston. Vita. Title from "catalog record" of the print edition Description based on contents viewed Apr. 15, 2008. Includes bibliographical references (leaves 94-111). Online version of the print edition.

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43

Schneider, Verena. "Association of selective and conventional nonsteroidal anti-inflammatory drugs with acute renal failure." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98793.

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The safety of the novel class of nonsteroidal anti-inflammatory drugs (NSAIDs), the COX-2 inhibitors, is currently debated, with the focus on their cardiovascular toxicity. Here, the association of NSAIDs with acute renal failure (ARF) was assessed in a nested case-control study using the administrative databases of Quebec.<br>The risk of ARF for all NSAIDs combined was highest within 30 days of treatment initiation (adjusted rate ratio (RR) 2.05, 95% confidence interval (CI) 1.61 - 2.60) and receded thereafter. After at least 30 days without an NSAID-prescription, the risk had returned to bas

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44

Suissa, Daniel. "Non-steroidal anti-inflammatory drugs and the risk of Clostridium Difficile-Associated Disease." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32594.

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Clostridium difficile is a bacterium which causes gastro-intestinal infection. The association between non-steroidal anti-inflammatory drugs (NSAIDs) and Clostridium difficile-associated disease (CDAD) has not been studied. Several case reports link diclofenac, an NSAID, with CDAD. In this thesis, we conducted a case-control study, using data from the United Kingdom's General Practice Research Database (GPRD), to examine the risk of CDAD associated with NSAID use. We identified 1,360 cases and 13,072 matc

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45

Wade, Lara Tamsin. "Identification and characterisation of hepatic protein adducts derived from nonsteroidal anti-inflammatory drugs." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287923.

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46

Somchit, Nhareet. "The role of protein adducts in the toxicity of nonsteroidal anti-inflammatory drugs." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284543.

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47

Landoni, Maria Fabiana. "Pharmacokinetics and pharmacodynamics of non steroidal anti-inflammatory drugs in horses and calves." Thesis, Royal Veterinary College (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281664.

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48

Brown, Gavin Robert. "The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs." Thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/23177.

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The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number of potential advantages that are conferred by complexation, such as improved b

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49

Bajpai, Sanjay Kumar. "Formulary decision making in health maintenance organizations involving non-steroidal anti-inflammatory drugs /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487777901657504.

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50

Silva, Milene Alexandra Cirne da. "Detection of non-steroidal anti-inflammatory drugs in aqueous effluents using ionic liquids." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15495.

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Mestrado em Biotecnologia - Biotecnologia Industrial e Ambiental<br>Significant improvements in human health have been achieved through the increased consumption of pharmaceutical drugs. However, most of these active pharmaceutical ingredients (APIs) are excreted by mammals (in a metabolized or unchanged form) into the environment. The presence of residual amounts of these contaminants was already confirmed in aqueous streams since treatment processes either wastewater treatment plants (WWTPs) or sewage treatment plants (STPs) are not specifically designed for this type of pollutants. Although

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