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Journal articles on the topic 'Antidiabetic and anti-inflammatory drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Hadid, Khalil A., Fawaz A. Alassaf, and Mohammed N. Abed. "Beyond blood sugar: exploring the anti-inflammatory frontier of antidiabetic medications to alleviate diabetic complications." Romanian Journal of Medical Practice 19, no. 1 (2024): 76–83. http://dx.doi.org/10.37897/rjmp.2024.1.11.

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Background and objective. Inflammation is closely correlated with diabetes and diabetic complications. Research has shown that individuals with diabetes exhibit an upregulation of circulatory proinflammatory cytokines, resulting in a chronic state of low-grade inflammation. The participation of inflammation in the pathogenesis of diabetic complications, particularly cardiovascular and renal complications, is well-established. Targeting inflammation may produce prominent effects in improving the clinical condition of diabetic patients, reducing the progression of complications, and promoting gl

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2

Eddouks, Mohamed, Debprasad Chattopadhyay, and Naoufel Ali Zeggwagh. "Animal Models as Tools to Investigate Antidiabetic and Anti-Inflammatory Plants." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/142087.

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Plants have been historically used for diabetes treatment and related anti-inflammatory activity throughout the world; few of them have been validated by scientific criteria. Recently, a large diversity of animal models has been developed for better understanding the pathogenesis of diabetes mellitus and its underlying inflammatory mechanism and new drugs have been introduced in the market to treat this disease. The aim of this work is to review the available animal models of diabetes and anti-inflammatory activity along with somein vitromodels which have been used as tools to investigate the

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Shamsudin, Nur Farisya, Qamar Uddin Ahmed, Syed Mahmood, et al. "Flavonoids as Antidiabetic and Anti-Inflammatory Agents: A Review on Structural Activity Relationship-Based Studies and Meta-Analysis." International Journal of Molecular Sciences 23, no. 20 (2022): 12605. http://dx.doi.org/10.3390/ijms232012605.

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Flavonoids are a group of naturally occurring polyphenolic secondary metabolites which have been reported to demonstrate a wide range of pharmacological properties, most importantly, antidiabetic and anti-inflammatory effects. The relationship between hyperglycaemia and inflammation and vascular complications in diabetes is now well established. Flavonoids possessing antidiabetic properties may alleviate inflammation by reducing hyperglycaemia through different mechanisms of action. It has been suggested that the flavonoids’ biochemical properties are structure-dependent; however, they are yet

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Chakravorty, Saibal, Indranil Purkait, Anil Pareek, and Avinash Talware. "Hydroxychloroquine: Looking into the Future." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 24, no. 4 (2017): 369–75. http://dx.doi.org/10.1515/rjdnmd-2017-0043.

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AbstractHydroxychloroquine, an antimalarial agent has also been found to possess antidiabetic action. Onset of type-2 diabetes (T2DM) and cardiovascular disease is now considered to be the outcome of systemic inflammation. Many clinical trials are targeting systemic inflammation to reduce cardiovascular risk. Anti-inflammatory drugs with cardiovascular effects may be valuable therapeutic intervention to reduce massive cardiovascular risk in T2DM. In this review, antidiabetic action and potential cardioprotective role of hydroxychloroquine has been discussed. By virtue of its antidiabetic, lipi

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VasudevaRao, Avupati. "PHYTOCHEMICAL SCREENING AND IN VITRO EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIDIABETIC PROPERTIES OF SINOMENIUM ACUTUM RHIZOME EXTRACT." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1110–27. https://doi.org/10.5281/zenodo.163854.

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Diabetes and inflammation are leading causes of fatality worldwide, accounting for millions of deaths every year. Although many drugs have been developed to treat these conditions effectively, some pharmacological incompatibilities could happen simultaneously. Therefore traditional natural product drugs to fight these conditions are more beneficial and are still urgently needed. Hence we have biologically evaluated Chinese traditional herb Sinomenium acutum rhizome extracts as potential antidiabetic and anti-inflammatory natural product by using suitable in vitro bioassays. The tested extracts

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Geetika, Vaisnav, K. Chakraborty Anup, and Karole Sarita. "Design, synthesis and evaluation of some novel derivatives of cinnamic acid as anti-inflammatory agents." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 088–96. https://doi.org/10.5281/zenodo.8037041.

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The role of Cinnamic acid derivatives as antioxidants, antimicrobial agents, antidiabetic drugs, anticancer drugs etc. is well reported. A thorough literature search revealed that the substitution on carboxylic acid group of Cinnamic acids by different amines imparts the potent conjugates. The quest for the design of effective anti-inflammatory drugs is still the primal focus of several research works world-wide owing to the side effects associated with the existing drugs. The side effects of the existing drugs are associated with the presence of the free carboxyl group in the molecules. In th

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7

Sangeetha, R. "Luteolin in the Management of Type 2 Diabetes Mellitus." Current Research in Nutrition and Food Science Journal 7, no. 2 (2019): 393–98. http://dx.doi.org/10.12944/crnfsj.7.2.09.

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Diabetes is an increasing pandemic and several million people are affectedbythis disease worldwide. The treatment of diabetes includes lifestyle modifications, oral antidiabetic drugs and insulin. The chronic use of oral antidiabetic drugs produces undesirable side effects. Hence safe alternative medicines are always sought after. Plant phytochemicals are the best alternatives as they possess a wide spectrum of pharmacological activities. Flavonoids are an important class of phytocomponent which is commonly present in fruits and vegetables. Luteolin belongs toflavone class of flavonoid which h

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8

Yongkhamcha, Butsara, та Nopparat Buddhakala. "Pumpkin Rind and Seeds Extracts Inhibit α - Glucosidase and Nitric Oxide Production and Promote Chlorella ellipsoidea Growth in Culture". Trends in Sciences 20, № 5 (2023): 6699. http://dx.doi.org/10.48048/tis.2023.6699.

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The objective of this work was to investigate the potential of pumpkin rind and seed on antidiabetic and anti-inflammatory activities and the underlying mechanism. Therefore, this work was carried out to determine the antidiabetic activity using inhibitory activities of pumpkin rind and seeds extracts on α - glucosidase and the anti-inflammatory activity via inhibitory activity on nitric oxide production. And also, the potential of the pumpkin rind and seeds on culture of Chlorella ellipsoidea was determined. Determination of inhibitory activity on α - glucosidase was performed using α - gluco

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9

A., S. Sontakke* R. S. Raut R.S. Ade R. S. Nikole R. S. Karanje R. G. Lokhande Dr. R. H. Kale. "Development And Assessment of Poly Herbal Tablet for Antidiabetic Activity." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2299–310. https://doi.org/10.5281/zenodo.15410928.

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The main goal of this project is to prepare and evaluate antidiabetic drugs based on drying, grinding and ethanol extraction using local excavation shower seeds, bone horn clover seeds, and gymnasium leaves. The above plants have good antidiabetic, antibacterial, antioxidant and anti-inflammatory properties. Tablets were manufactured according to a preliminary language study and measured based on body weight change, hardness, spring time, thickness, and decay time.

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10

Kim, Se-Eun, and Byung-Su Yoo. "Anti-Diabetic Drugs in Cardiovascular Disease." Korean Journal of Medicine 96, no. 2 (2021): 85–91. http://dx.doi.org/10.3904/kjm.2021.96.2.85.

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Diabetes is one of the important risk factors in cardiovascular disease associated with atherosclerosis, and cardiovascular disease is the leading cause of death in patients with diabetes mellitus. Recent randomized placebo-controlled cardiovascular outcome trials of all new antidiabetic drugs have linked SGLT-2 inhibitors and GLP1-agonists to not only increased cardiovascular stability but significant reduction of cardiovascular disease. These results have led to preferential selection of the most effective and beneficial antidiabetic drugs with the evidence of cardiovascular safety and effic

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11

Nabiyev, Jasurbek Qosimjon o'g'li. "EVALUATION OF ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITIES OF SOME MEDICINAL PLANTS." UNIVERSAL XALQARO ILMIY JURNAL 1, no. 4 (2024): 40—. https://doi.org/10.5281/zenodo.12770983.

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The possibilities of using local plants with unknown medicinal properties as pancreatic α-amylase inhibitors were investigated. Among the 8 selected plants, it was found that the concentration of 100 mg/ml of ethanol extracts of frankincense, chamomile, and marigold (80%, 77%, and 72%, respectively) has a high inhibitory activity. Anti-inflammatory properties of drugs used in the treatment of diabetes have been proven to be effective tools in reducing diabetes-related complications. Accordingly, the anti-inflammatory properties of ethanol extracts of frankincense, chamomile, and marigold

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12

Geetika Vaisnav, Anup K Chakraborty, and Sarita Karole. "Design, synthesis and evaluation of some novel derivatives of cinnamic acid as anti-inflammatory agents." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 088–96. http://dx.doi.org/10.30574/wjbphs.2023.14.1.0164.

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The role of Cinnamic acid derivatives as antioxidants, antimicrobial agents, antidiabetic drugs, anticancer drugs etc. is well reported. A thorough literature search revealed that the substitution on carboxylic acid group of Cinnamic acids by different amines imparts the potent conjugates. The quest for the design of effective anti-inflammatory drugs is still the primal focus of several research works world-wide owing to the side effects associated with the existing drugs. The side effects of the existing drugs are associated with the presence of the free carboxyl group in the molecules. In th

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13

Chitturi, Shivakumar, and Jacob George. "Hepatotoxicity of Commonly Used Drugs: Nonsteroidal Anti-Inflammatory Drugs, Antihypertensives, Antidiabetic Agents, Anticonvulsants, Lipid-Lowering Agents, Psychotropic Drugs." Seminars in Liver Disease 22, no. 02 (2002): 169–84. http://dx.doi.org/10.1055/s-2002-30102.

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14

Singh, Sucheta, Sumit Tahlan, and Prabhakar Kumar Verma. "SYNTHESIS, CHEMISTRY, In-vitro ANTIMICROBIAL, ANTIOXIDANT, ANTIDIABETIC AND ANTIINFLAMMATORY ACTIVITY OF BISPYRAZOLE DERIVATIVES: A RESEARCH." RASAYAN Journal of Chemistry 15, no. 03 (2022): 2133–47. http://dx.doi.org/10.31788/rjc.2022.1537018.

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A series of bispyrazole compounds were designed, synthesized, and evaluated for their biological potential against micro-organisms, pro-oxidants (oxidative stress), inflammation, and diabetes. The synthesized derivatives were examined by tube dilution technique for in vitro antimicrobial potential against different microbial strains. In the series, compounds K8 (MICbs=26.39 µg/mL), K11 (MICbs=13.63 µg/mL), K12 (MICbs=13.63 µg/mL) and K22 (MICbs=12.12, 6.06 µg/mL) showed significant antibacterial activity as compared to standard drugs whereas compound K4 (MICan,ca= 6.80 µg/mL) and K17 (MICan,ca

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15

Utami, Ayudiah Rizki, Iman Permana Maksum, and Yusi Deawati. "Berberine and Its Study as an Antidiabetic Compound." Biology 12, no. 7 (2023): 973. http://dx.doi.org/10.3390/biology12070973.

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Diabetes mellitus (DM) is a metabolic disorder that causes hyperglycemia conditions and leads to various chronic complications that causes death. The prevalence of diabetes is predicted to continue to increase, and with the high toxicity levels of current diabetes drugs, the exploration of natural compounds as alternative diabetes treatment has been widely carried out, one of which is berberine. Berberine and several other alkaloid compounds, including some of its derivatives, have shown many bioactivities, such as neuraminidase and hepatoprotective activity. Berberine also exhibits antidiabet

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16

Zhan, Ze-Tao, Lu Liu, Ming-Zhen Cheng, Yi Gao, and Wei-Jie Zhou. "The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment." Journal of Immunology Research 2022 (August 18, 2022): 1–24. http://dx.doi.org/10.1155/2022/2651790.

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Diabetes and cancer are common diseases and are frequently diagnosed in the same individual. These patients need to take antidiabetic drugs while receiving antitumor drugs therapy. Recently, immunotherapy offers significant advances for cancer treatment. However, it is unclear whether antidiabetic drugs affect immunotherapy. Here, by employing syngeneic mouse colon cancer model and melanoma model, we studied the effects of 6 common antidiabetic drugs on anti-PD1 immune checkpoint inhibitor in tumor treatment, including acarbose, sitagliptin, metformin, glimepiride, pioglitazone, and insulin. W

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17

Katsiki, Niki, and Ele Ferrannini. "Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?" Journal of Diabetes and its Complications 34, no. 12 (2020): 107723. http://dx.doi.org/10.1016/j.jdiacomp.2020.107723.

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18

Dayma, Varsha, Jaishri Chopra, Poonam Sharma, et al. "Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs." Heliyon 6, no. 8 (2020): e04787. http://dx.doi.org/10.1016/j.heliyon.2020.e04787.

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19

Careen, Liza Pakyntein, Syiem Donkupar, Thabah Daiahun, and Ediemi Sunn Shelareen. "Antioxidant, anti-inflammatory and anti-hyperglycemic activity of aqueous and methanolic extract of Houttuynia cordata: an in vitro and in vivo study." GSC Biological and Pharmaceutical Sciences 16, no. 3 (2021): 145–54. https://doi.org/10.5281/zenodo.5542920.

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Available synthetic antioxidants such as butylated hydroxyl anisole, butylated hydroxyl toluene, propyl gallate, and ascorbic acid exhibit several side effects. To curb these side effects, more effective, less toxic, and cost-effective drugs are required. Therefore, this study aims to screen and evaluate the antioxidant as well as the anti-inflammatory and antidiabetic potential of <em>Houttuynia cordata</em> collected from Mairang village, West Khasi Hills, Meghalaya, India using several standard methods. The aqueous and methanolic extracts of <em>H. cordata</em> were eval

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20

T, Benoite, and Nora Vigasini K. "Evaluation Of Antioxidant, Antidiabetic, Anti-Inflammatory And Anticancer Activities Of Delonix Regia Flower Extracts." International Journal of pharma and Bio Sciences 11, no. 6 (2021): 103–15. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.l103-115.

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Non-communicable diseases like diabetes and cancer are the major cause of death worldwide. Various drugs are used for the treatment of these diseases. However, they cause lots of side effects. There is a need for alternate drugs with fewer side effects. Medicinal plants serve as a good source for alternate form of treatment. Therefore, in this study, ethanolic and aqueous extracts of D. regia flowers were evaluated for their antioxidant, antidiabetic, anti-inflammatory and cytotoxic activity to justify its use as a medicinal plant. Total phenol and flavonoid content of the extracts were measur

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21

Navneet Singh and Fahad Adil. "An Insight into Anticorrosive Profiling of Drugs." International Research Journal on Advanced Science Hub 7, no. 04 (2025): 305–25. https://doi.org/10.47392/irjash.2025.037.

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Drugs play an important role for the wellness of communities all over the world. In addition, their potential cannot be ignored for commercial point of view especially as anticorrosive agents. We have done an intensive study for drugs such as antibiotic, anti-inflammatory, antihistamine, antifungal, antibacterial, antihypertensive, antidiabetic and other categories, to explore their potential as anti-corrosive agents against various metals. These drugs have been studied in acidic environments such as HCl, H2SO4, H3PO4, and NaCl against a variety of metals including mild steel, carbon steel, al

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Rahman, Md Anisur, Md Abdus Salam, Md Zakir Sultan, Khohinur Hossain, Asma Rahman, and Mohammad A. Rashid. "DSC and HPLC Studies of Some Common Antidiabetic and Antihypertensive Drugs." Bangladesh Pharmaceutical Journal 17, no. 2 (2015): 123–27. http://dx.doi.org/10.3329/bpj.v17i2.22326.

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Now-a-days, a significant percentage of our population suffers from diabetes, hypertension and various inflammatory conditions. In such cases antihypertensive, antidiabetic and anti inflammatory drugs are prescribed concomitantly. Therefore, there is a possibility to have drug-drug interactions which may cause various complications to the patients or may be beneficial too. So study of drug-drug interaction is very important. To attain this objective, equimolar homogeneous mixture of naproxen, losartan potassium and pioglitazone HCl (mixture-1) and mixture of lercanidipine, captropril, naproxen

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Jagruti, D. Khapare, A. Ghorad Bhavana, M. Chande Mayuri, and Bhoir Prashant. "A Review on Anti Diabetic Activity of Herbal Drugs(Eculaptus Globules and Jamun)." International Journal of Innovative Science and Research Technology (IJISRT) 10, no. 1 (2025): 703–8. https://doi.org/10.5281/zenodo.14724956.

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Eucalyptus globulus is a plant that is frequently seen. Blue gum, or Eucalyptus globulus, is a species of flowering plant belonging to the Myrtaceae family. This plant thrives on the Nilgiri Hills. that seek to investigate the anti-diabetic properties of eucalyptus globulus. which are found in the plant's roots, leaves, and steam. globulus eucalyptus using water as a solvent. Saponins, tannins, flavonoids, and propanoids were among the plant parts found in the dried fresh leaves used to test the extracts for phytochemical screening and antibacterial activity. Numerous reviews and research arti

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Bushnak, Razan, Mohamad El Hajj, and Ali Jaber. "A Review on the Antidiabetic Potential of Medicinal Plants." Sumerianz Journal of Medical and Healthcare, no. 44 (November 18, 2021): 172–89. http://dx.doi.org/10.47752/sjmh.44.172.189.

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Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adve

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Eddine, Laouini Salah, Ladjel Segni, Gherraf Noureddine, Ouahrani Mohammed Redha, and Mokni Sonia. "Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of Phoenyx dactylifera l." International Letters of Chemistry, Physics and Astronomy 14 (September 2013): 125–35. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.14.125.

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In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amyla

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Eddine, Laouini Salah, Ladjel Segni, Gherraf Noureddine, Ouahrani Mohammed Redha, and Mokni Sonia. "Scavenging Activity, Anti-Inflammatory and Diabetes Related Enzyme Inhibition Properties of Leaves Extract from some Varieties of <i>Phoenyx dactylifera l.</i>." International Letters of Chemistry, Physics and Astronomy 14 (May 19, 2013): 125–35. http://dx.doi.org/10.56431/p-8430hg.

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In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amyla

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27

Sai Prasanna, K., G. Jyothi Reddy, M. Kiran, and K. Thyaga Raju. "Biological Activities and Phytochemical Constituents of Trailing Daisy Trilobata: A Review." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 888–92. http://dx.doi.org/10.22270/jddt.v9i4-s.3578.

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The traditional system of medicinal plants have been found to possess significant anti-inflammatory, antibacterial, anti-fungal, anti-diabetic, analgesic properties etc. Plant-derived drugs are used to cure mental illness, skin diseases, tuberculosis, diabetes, jaundice, hypertension, and cancer. Wedelia Trilobata belongs to family Asteraceae. Leaf, stem, and flower of Wedelia trilobata show anti-microbial, anti-oxidant and anti-inflammatory activity, analgesic activity. Phytochemical screening of the extract has been reported to show the presence of tannins, cardiac glycosides, flavonoids, te

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Wan, Mengxia, Linjing Zhang, Junyan Huo, Yu Fu, Tao Huang, and Dongsheng Fan. "Genetic Variation in Targets of Antidiabetic Drugs and Amyotrophic Lateral Sclerosis Risk." Biomedicines 12, no. 12 (2024): 2733. http://dx.doi.org/10.3390/biomedicines12122733.

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Background: Previous studies have suggested that antidiabetic drug use may be associated with amyotrophic lateral sclerosis. However, these studies are limited by many confounding and reverse causality biases. We aimed to determine whether antidiabetic drug use has causal effects on ALS. Methods: Drug-target Mendelian randomization analysis was conducted to evaluate the association between genetic variation in the targets of antidiabetic drugs and ALS risk. The antidiabetic drugs included sulfonylureas, GLP-1 analogues, thiazolidinediones, insulin/insulin analogues, metformin, and SGLT2 inhibi

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Indiastuti, Danti Nur, Nada Salsabila, Bellinda Zalzabillah Tazkira, Arifa Mustika, Suharjono, and Sukardiman. "In silico approach of Garcinia mangostana and Ortosiphon stamineus to restore adipokines level as drug candidate for metabolic syndrome." Pharmacy Education 24, no. 3 (2024): 159–65. http://dx.doi.org/10.46542/pe.2024.243.159165.

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Background: Metabolic syndrome is a group of metabolic disorders due to dysfunctional adipose tissue. Adipose tissue is an endocrine organ that secretes many pro-inflammatory and anti-inflammatory adipokines. Garcinia mangostana and Orthosiphon stamineus have demonstrated various pharmacological effects, including antidiabetic, anti-dyslipidemia, antiobesity, antioxidant, and anti-inflammatory properties. Objective: This study aimed to analyse the interaction of phytochemical compounds from Garcinia mangostana and Orthosiphon stamineus in decreasing levels of pro-inflammatory adipokines while

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Lahlou, Radhia Aitfella, Filomena Carvalho, Maria João Pereira, João Lopes, and Luís R. Silva. "Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential." Pharmaceutics 16, no. 4 (2024): 454. http://dx.doi.org/10.3390/pharmaceutics16040454.

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The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic appl

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Balaji Subramaniyan R, Jaikumar S, and Sekkizhar M. "In-vitro Anti-Inflammatory activity of Digera muricata Extracts." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 5748–51. http://dx.doi.org/10.26452/ijrps.v11i4.3220.

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Inflammation is a process that is generally termed for pain and redness, which includes swelling. But it is defined as a heterogeneous group of processes which result in the pain and increase in vascular circulation and denaturation of protein that results in tissue degeneration. There are many synthetic drugs available to treat and relieve the inflammation. They are potent and have many side effects too. So there is an increased search for alternative means of treatment option. Thereby there was a high focus on the medicinal plants and herbs. Digera muricate, which is used to treat many disea

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Peerzade, Nargisbano A., Shravan Y. Jadhav, and Raghunath B. Bhosale. "Synthesis and Biological Evaluation of Some Novel Quinoline based Chalcones as Potent Antimalarial, Anti-inflammatory, Antioxidant and Antidiabetic Agents." Asian Journal of Chemistry 32, no. 4 (2020): 959–64. http://dx.doi.org/10.14233/ajchem.2020.22542.

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The objective of the present study was to synthesize a series of some novel quinoline based methoxy substituted chalcones and to evaluate their in vitro antimalarial, anti-inflammatory, antioxidant and antidiabetic activitites. The quinoline based chalcones was synthesized by condensation of 2-chloro-3-formyl qunoline with various methoxy substituted acetophenone in presence of NaOH. The Claisen-Schmidt condensation gave high yield of quinoline based chalcones. Synthesis of 2-chloro-3-formyl quinoline was carried out by Vilsmeir-Haack reaction on acetanilide and 4-methoxy acetanilide which on

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Nath, Ranjit Kumar, Neeraj Pandit, Ajay Raj, et al. "Cardiovascular outcomes of antidiabetic drugs." Asian Journal of Medical Sciences 12, no. 3 (2021): 98–106. http://dx.doi.org/10.3126/ajms.v12i3.32477.

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Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular disease (ASCVD). Intensive blood glucose reduction with antidiabetic drugs significantly reduce microvascular complications but there is no strong evidence of reduction in cardiovascular (CV) events. In 2008, the US Food and Drug Administration (FDA) issued guidance to demonstrate cardiovascular safety of newer antidiabetic drugs in addition to reduction in blood glucose level. After which a number of CVOTs were conducted involving newer antidiabetic drugs. The newer drugs (e.g. GLP-1 RAs, SGLT2 in

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Ranjit Kumar Nath, Neeraj Pandit, Ajay Raj, et al. "Cardiovascular outcomes of antidiabetic drugs." Asian Journal of Medical Sciences 12, no. 3 (2021): 98–106. https://doi.org/10.71152/ajms.v12i3.3577.

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Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular disease (ASCVD). Intensive blood glucose reduction with antidiabetic drugs significantly reduce microvascular complications but there is no strong evidence of reduction in cardiovascular (CV) events. In 2008, the US Food and Drug Administration (FDA) issued guidance to demonstrate cardiovascular safety of newer antidiabetic drugs in addition to reduction in blood glucose level. After which a number of CVOTs were conducted involving newer antidiabetic drugs. The newer drugs (e.g. GLP-1 RAs, SGLT2 in

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Kuryłowicz, Alina, and Krzysztof Koźniewski. "Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes." Molecules 25, no. 9 (2020): 2224. http://dx.doi.org/10.3390/molecules25092224.

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One of the concepts explaining the coincidence of obesity and type 2 diabetes (T2D) is the metaflammation theory. This chronic, low-grade inflammatory state originating from metabolic cells in response to excess nutrients, contributes to the development of T2D by increasing insulin resistance in peripheral tissues (mainly in the liver, muscles, and adipose tissue) and by targeting pancreatic islets and in this way impairing insulin secretion. Given the role of this not related to infection inflammation in the development of both: insulin resistance and insulitis, anti-inflammatory strategies c

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Hazra, Samik, Anindya Sundar Ray, Swetarka Das, Arunava Das Gupta, and Chowdhury Habibur Rahaman. "Phytochemical Profiling, Biological Activities, and In Silico Molecular Docking Studies of Causonis trifolia (L.) Mabb. & J.Wen Shoot." Plants 12, no. 7 (2023): 1495. http://dx.doi.org/10.3390/plants12071495.

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Causonis trifolia (L.) Mabb. & J.Wen, commonly known as “fox grape”, is an ethnomedicinally important twining herb of the Vitaceae family, and it is used by ethnic communities for its wide range of therapeutic properties. Our research aims to investigate the chemical composition; antioxidant, anti-inflammatory, and antidiabetic activities; and mechanisms of interaction between the identified selective chemical compounds and the target proteins associated with antioxidant, anti-inflammatory, and antidiabetic effects of the optimised phenolic extract of Causonis trifolia (L.) Mabb. & J.W

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Sharipov, Avez, Khurshid Tursunov, Sunnatullo Fazliev, Bahtigul Azimova, and Jamoliddin Razzokov. "Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds." Molecules 26, no. 13 (2021): 3784. http://dx.doi.org/10.3390/molecules26133784.

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Horse chestnut (Aesculus hippocastanum L.)-derived drugs have shown their potential in biomedical applications. The seed of A. hippocastanum contains various kinds of chemical compounds including phenolics, flavonoids, coumarins, and triterpene saponins. Here, we investigated the chemical components in A. hippocastanum L. grown in Uzbekistan, which has not yet been studied in detail. We identified 30 kinds of triterpene saponins in an extract of A. hippocastanum L. Classifying extracted saponins into eight fractions, we next studied the hypoglycemic and the anti-inflammatory activities of esci

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Maurya, Anupam, Sweta Mohan, and Subash C. Verma. "Antidiabetic Potential of Naturally Occurring Sesquiterpenes: A Review." Current Topics in Medicinal Chemistry 21, no. 10 (2021): 851–62. http://dx.doi.org/10.2174/1568026621666210305102500.

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Diabetes Mellitus (DM) is an endocrine disease, which is the 3rd leading cause of death in humans; additionally, it is one of the major key concerns over the globe. The high levels of glucose in the blood stream are as well characterized by hyperglycaemia leading to serious damage to the heart, blood vessels, kidney, eyes, and nerves. The best treatment of DM is still not available; many scientists worldwide are trying hard to seek out suitable treatment of DM. Though numerous synthetic drugs are developed for the treatment of diabetes but their utility has been hampered because of several sid

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Infante, Marco, Nathalia Padilla, Rodolfo Alejandro, et al. "Diabetes-Modifying Antirheumatic Drugs: The Roles of DMARDs as Glucose-Lowering Agents." Medicina 58, no. 5 (2022): 571. http://dx.doi.org/10.3390/medicina58050571.

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Systemic inflammation represents a shared pathophysiological mechanism which underlies the frequent clinical associations among chronic inflammatory rheumatic diseases (CIRDs), insulin resistance, type 2 diabetes (T2D), and chronic diabetes complications, including cardiovascular disease. Therefore, targeted anti-inflammatory therapies are attractive and highly desirable interventions to concomitantly reduce rheumatic disease activity and to improve glucose control in patients with CIRDs and comorbid T2D. Therapeutic approaches targeting inflammation may also play a role in the prevention of p

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Sushil, Kumar Tiwari. "Analgesic Activity and Anti-Inflammatory Activities of The Ethanolic Extract of Cassia Auriculata Leaves." International Journal of Medical and Pharmaceutical Research 4, no. 1 (2023): 25–31. https://doi.org/10.5281/zenodo.7501954.

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Drugs which are in use presently for the management of pain and inflammatory conditions are either narcotics e.g. opioids or non-narcotics e.g. salicylates and corticosteroids e.g. hydrocortisone.  All of these drugs present well known side and toxic effects. More over synthetic drugs are very expensive to develop since, for the successful introduction of a new product approximately 3000-4000 compounds are to be synthesized, screened and tested whose cost of development ranges from 0.5 to 5 million dollars. On the contrary many medicines of plant origin had been used since long time witho

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Venkataesan Kumari, Bhuvaneshwari, Renuka Mani, Balakrishnan Ramajayam Asokan, et al. "Green Synthesised Silver Nanoparticles Using Anoectochilus elatus Leaf Extract: Characterisation and Evaluation of Antioxidant, Anti-Inflammatory, Antidiabetic, and Antimicrobial Activities." Journal of Composites Science 7, no. 11 (2023): 453. http://dx.doi.org/10.3390/jcs7110453.

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The present study investigates the green synthesis of silver nanoparticles was carried out using a leaf extract of Anoectochilus elatus (Ae-AgNPs). The synthesised Ae-AgNPs were characterised using different analytical techniques like UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX). Additionally, in vitro activities were investigated, and they possess antioxidant, anti-inflammatory, antidiabetic, and antimicrobial properties. The UV-Vis spectra exhibited characteristic absorp

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Jitender, K. Malik, Yadav Bhavana, Pratap Yadav Abhay, and Soni Himesh. "Phytography & Phytopharmacology of Genus cassia." Journal of Advances in Bio- pharmaceutics and Pharmacovigilance 2, no. 2 (2020): 1–9. https://doi.org/10.5281/zenodo.3733030.

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The utilization of botanicals has gained more significance because of its natural origin and high therapeutic significance. The various species of the genus <em>Cassia</em> has many novel phytoceuticals which showed many pharmacological activities such as antioxidant, anti inflammatory, antimicrobial, antidiabetic etc., which is beneficial effect on human health. The review focus on morphological description and pharmacological importance of various species of genus <em>Cassia </em>with special emphasis on<em> C.sophera, C.tora, C.occidentalis, C.fistula & C.auriculata.</em>, which will of

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Yaribeygi, Habib, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, and Amirhossein Sahebkar. "Impact of Incretin-Based Therapies on Adipokines and Adiponectin." Journal of Diabetes Research 2021 (October 7, 2021): 1–9. http://dx.doi.org/10.1155/2021/3331865.

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Adipokines are a family of hormones and cytokines with both pro- and anti-inflammatory effects released into the circulation to exert their hormonal effects. Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. In this review, we p

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Wojciechowska, Eliza, and Bogusław Okopień. "What Do We Know about Flozins: New, Pleiotropic Drugs." Journal of Health Study and Medicine 2023, no. 1 (2023): 247–73. http://dx.doi.org/10.2478/jhsm-2023-0013.

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Abstract Civilization diseases affect more and more people globally. As a World Health Organization reports in 2016 more than 1.9 billion of adults were overweight and excess body mass is the leading risk factor for developing diabetes affecting approximately 422 million people worldwide (90% is DM2). It has seemed that the link between obesity, diabetes, and cardiovascular complications is a low-grade chronic inflammation that is observed in all tissues involved in energy homeostasis and is characterized by the activation of pro-inflammatory macrophages so-called M1. The increasing number of

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Guo, Shengnan, Li Zhang, Shentao Wu, and Hongyi Liu. "Research progress of typical flavonoids in improving insulin resistance." Archives of Medical Science – Atherosclerotic Diseases 5, no. 1 (2020): 335–42. http://dx.doi.org/10.5114/amsad.2020.103472.

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Flavonoids are a large class of compounds that are widely found in many plants, including plants used in Chinese herbal medicines. Previous studies have revealed that flavonoids possess biomedical activities, including antioxidant, anti-cancer, anti-viral, and anti-inflammatory properties. They also have the functions of lowering lipids, lowering blood sugar, and improving insulin resistance. This article selects four typical compounds of flavonoids, namely baicalin, baicalein, quercetin, and rutin, and reviews their effects and mechanisms of action in improving insulin resistance. With a view

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Hadisaputri, Yuni Elsa, Annida Adha Nurhaniefah, Sendi Sukmara, Ade Zuhrotun, Rini Hendriani, and Iyan Sopyan. "Callyspongia spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms." Metabolites 13, no. 2 (2023): 217. http://dx.doi.org/10.3390/metabo13020217.

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One of the most widespread biotas in the sea is the sponge. Callyspongia is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of Callyspongia spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, Callyspongia spp. was reported to posse

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Ankit, Sharma* Dr Dev Prakash Dahiya Anchal Sankhyan Vishal. "Plant Dicliptera bupleuroide is a source of Anti-oxidant, anti-inflammatory and some phytoconstituents which help in wound healing-Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1718–23. https://doi.org/10.5281/zenodo.15047163.

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Dicliptera bupleuroides is a perennial herb that is used medicinally and is a member of the Acanthaceae family. In local language , Dicliptera bupleuroides is referred to as kaalu or kirch. It is present in the planes of Afghanistan and Pakistan. Dicliptera bupleuroides has a wide range of pharmacological characteristics, including antioxidant , antidiabetic , antimicrobial, hepatoprotective and other biological activities. It contain phenols, lipids, flavonoids, starch, glycosides and ascorbic acid. The purpose of this review article is to document the latest data about its medicinal use, tra

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Panasenko, O. I., V. I. Mozul, O. M. Denysenko, I. I. Aksonova, and T. V. Oberemko. "Chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 179–84. http://dx.doi.org/10.14739/2409-2932.2021.2.233708.

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The aim of the work was chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L. fruits and leaves and identifying further prospects for the use of this plant in medicine. Materials and methods. Raw materials of Elaeagnus angustifolia L. were selected as objects of study. The tincture was obtained by maceration and the raw material was extracted with methyl alcohol at room temperature for 10 days according to the method of making tinctures. The study of the chemical composition of Elaeagnus angustifolia L. was carried out using gas chromatograph Agilent 7890B G

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Lourenço, Tânia, and Nuno Vale. "Pharmacological Efficacy of Repurposing Drugs in the Treatment of Prostate Cancer." International Journal of Molecular Sciences 24, no. 4 (2023): 4154. http://dx.doi.org/10.3390/ijms24044154.

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Worldwide, prostate cancer (PC) is the second most frequent cancer among men and the fifth leading cause of death; moreover, standard treatments for PC have several issues, such as side effects and mechanisms of resistance. Thus, it is urgent to find drugs that can fill these gaps, and instead of developing new molecules requiring high financial and time investments, it would be useful to select non-cancer approved drugs that have mechanisms of action that could help in PC treatment, a process known as repurposing drugs. In this review article, drugs that have potential pharmacological efficac

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Indu, Rania, Anjan Adhikari, T. K. Sur, and Piyali Basak. "Elucidation of the effect of concomitant administration of Metformin and Diclofenac Sodium on insulin resistance, pro-inflammatory cytokines and oxidative stress markers in in vivo models." Research Journal of Biotechnology 16, no. 7 (2021): 48–57. http://dx.doi.org/10.25303/167rjbt4821.

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Prevalence of chronic disorders like arthritis is frequently observed in diabetic patients, especially among the geriatric population. To combat such a situation, non-steroidal anti-inflammatory drugs (NSAIDs) are mostly co-prescribed along with antidiabetics. Thus present study tried to evaluate the safety and efficacy of concomitant use of drugs in animals induced with comorbid conditions. Diabetes and chronic inflammation were induced in rats by Streptozotocin and Nicotinamide and Freund’s Complete Adjuvant respectively. These medical conditions were treated with antidiabetic Metformin and

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