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Journal articles on the topic 'Antidiabetic bioactivity'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Adawiah, Adawiah. "Kandungan Fitokimia dan Bioaktivitas Ekstrak Metanol Biji Palem Putri (Veitchia merillii)." Jurnal Kimia VALENSI 2, no. 1 (2016): 63–70. http://dx.doi.org/10.15408/jkv.v2i1.3076.

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Palem putri (Veitchia merillii) is a kinds of Araceae plant which has been used by the community in cure myopic eyes and for woman who have pregnant. However, research on the content of secondary metabolites and bioactivity of palm putri has never been done. This study aims to determine the phytochemical content, total polyphenols and flavonoids and bioactivity include antioxidant activity DPPH free radical scavenging, antidiabetic method alpha-glucosidase enzyme inhibition and toxicity of the methods Bhrine Shrimp Lethal Test (BSLT). Palem putri contains secondary metabolites, alkaloids, flav

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Wang, Kaiping, Zhuohong Tang, Ziming Zheng, et al. "Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocin-induced type 2 diabetic BALB/c mice." Food & Function 7, no. 12 (2016): 4889–97. http://dx.doi.org/10.1039/c6fo01196a.

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Rašeta, Milena, Mira Popović, Ivan Čapo, et al. "Antidiabetic effect of two different Ganoderma species tested in alloxan diabetic rats." RSC Advances 10, no. 17 (2020): 10382–93. http://dx.doi.org/10.1039/c9ra10158f.

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4

Virgilius, Raja David, and Irmanida Batubara. "Antidiabetic Bioactivity of Ethyl Acetate Extract of Fungus Comb." IJCA (Indonesian Journal of Chemical Analysis) 7, no. 2 (2024): 1–11. http://dx.doi.org/10.20885/ijca.vol7.iss2.art1.

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The ethyl acetate extract of fungus comb was investigated for its potential as an α-glucosidase enzyme inhibition agent. The extract was evaluated using bioassay methods to determine its IC50 values against enzyme activity, alongside phytochemical screening to identify active compounds. The optimal concentration of α-glucosidase enzyme was determined to be 0.06 U/mL. Results indicated that the extract and its fractions exhibited α-glucosidase enzyme inhibition activity, albeit with IC50 values higher than the positive control, acarbose. Fractions containing phenol-hydroquinone showed the most

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5

Tafzi, Fitri. "BIOACTIVITY OF CINNAMON (Cinamomum sp)." Indonesian Food Science & Technology Journal 3, no. 1 (2020): 18–22. http://dx.doi.org/10.22437/ifstj.v3i1.10191.

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Abstract-Cinnamon has been widely used as a spice in food and medicine. Cinnamon grow in the Asian region. Indonesia is one of the cinnamon producing countries. The chemical composition of cinnamon plants varies according to the variety, the part of the plant, the place and the climate to grow. The main bioactive component in cinnamon bark is cynnamaldehide. Cynnamaldehide in cinnamon has good physiological effects on body health such as antioxidants, anticancer, anti-inflammatory, antidiabetic, antidyslipidemicanti-hyperuricemia, and antimicrobial properties. Research is generally still condu

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Tanriverdi, Başak, Ali Şen, Narin Sadıkoğlu, and Leyla Bitiş. "Bioactivity guided fractionation for investigation of antidiabetic activity on the different Origanum species from the Brevifilamentum section." Journal of Research in Pharmacy 29, no. 3 (2024): 1295–300. https://doi.org/10.12991/jrespharm.1712372.

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The aim of this study was to evaluate antidiabetic activities of Origanum bargyli (OB), Origanum haussknechtii (OH), Origanum rotundifolium (OR) species from Brevifilamentum section of genus Origanum and to investigate their roles in diabetes with the support of their antioxidant effects. Antidiabetic activities on OB, OH, and OR were investigated for the first time in the present study. DPPH and ABTS radicals scavenging, α-glucosidase inhibition methods were performed for antioxidant, antidiabetic activities, respectively. OB (12.70 and 32.62 μg/mL) and OR (10.61 and 32.28 μg/mL) exhibited st

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Bansode, Pranali Vijay, Kiran Shivaji Patil, and Ashok Ananda Hajare. "Bioactivity Guided Antidiabetic Formulation Development of Tridax procumbens Linn Leaves." Indian Journal of Pharmaceutical Education and Research 54, no. 3 (2020): 705–13. http://dx.doi.org/10.5530/ijper.54.3.121.

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8

B., V. Malavika T. S. Ramya Swathi Naraparaju*. "In Silico ADME, Bioactivity, Toxicity Predictions and Molecular Docking Studies Of A Few Antidiabetics Drugs." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 924–37. https://doi.org/10.5281/zenodo.14862825.

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Computer-aided drug design (CADD) methodologies have become essential in modern drug discovery, offering significant cost and time efficiency. By analyzing the physicochemical properties, bioactivity, and toxicity profiles of existing drugs, researchers can identify key pharmacophoric features crucial for designing novel compounds targeting specific biological pathways. In this study, 27 FDA-approved antidiabetic drugs (since 1957) were selected for computational analysis. Their physicochemical properties, bioactivity scores, and toxicological profiles were predicted using various tools, inclu

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Talwar, Archna, Neha Chakraborty, Manaal Zahera, et al. "Antidiabetic Potential of Phytochemicals Found in Vernonia amygdalina." Journal of Chemistry 2024 (March 26, 2024): 1–12. http://dx.doi.org/10.1155/2024/6111603.

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Type 2 diabetes mellitus (T2DM), or “insulin-independent diabetes mellitus,” is a worldwide health concern. Diabetes affects roughly 415 million individuals worldwide, with 193 million undiagnosed cases. The number of people afflicted in the following decades is predicted to double. Although various synthetic medications are currently available to treat/manage T2DM, their side effects compel researchers to seek novel treatment options. Because of their affinity for biological receptors and broad bioactivity, nature has long been a source of innovative medication. V. amygdalina is one of the nu

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Silalahi, Marina. "BIOAKTIVITAS ASAM JAWA (Tamarindus indica) DAN PEMANFAATANNYA." Florea : Jurnal Biologi dan Pembelajarannya 7, no. 2 (2020): 85. http://dx.doi.org/10.25273/florea.v7i2.7323.

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Tamarindus indica is one of the species in the Fabaceae which is widely used as food and traditional medicine. T. indica has naturalized in Indonesia, especially in Java Island and mostly only used as food, while its use as medicine is still limited. This study aims to explain the relationship between the use of T. indica as a traditional medicine and its bioactivity. The method used in this study is based on literature studies obtained online using the key word Tamarindus indica, uses of T. indica and bioactivities of T. indica. The use of T. indica as a traditional medicine is related to its

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11

Sabir, Alveena, Naila Safdar, Wasim Akhtar, Iram Fatima, and Gul-e.-Saba Chaudhry. "Therapeutic Potential of Fabaceae Species: A Phytochemical and Bioactivity Investigation." Ars Pharmaceutica (Internet) 66, no. 3 (2025): 301–13. https://doi.org/10.30827/ars.v66i3.32353.

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Introduction: The increasing prevalence of chronic diseases and infectious ailments necessitates the exploration of novel therapeutic agents. This study aims to elucidate selected Fabaceae species’ phytochemical composition and biological activities. Methods: Antioxidant potential was assessed with the DPPH assay, while DNA protection and antidiabetic activity were tested via inhibition assays. Anti-leishmanial and anti-dengue potentials were evaluated against Leishmania major and Aedes aegypti. Results: Sophora mollis, Mucuna pruriens, and Sesbania sesbans exhibited the highest phytochemical

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Ibrahim, Muhammad, Shehla Munir, Sarfraz Ahmed, et al. "Gliclazide in Binary and Ternary Systems Improves Physicochemical Properties, Bioactivity, and Antioxidant Activity." Oxidative Medicine and Cellular Longevity 2022 (November 25, 2022): 1–20. http://dx.doi.org/10.1155/2022/2100092.

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The poor solubility of the antidiabetic drug gliclazide (Glc) is due to its hydrophobic nature. This research is aimed at improving Glc’s solubility and drug release profile, as well as at investigating additional benefits such as bioactivity and antioxidant activity, by forming binary complexes with HPβCD at different w / w ratios (1 : 1, 1 : 2.5, 1 : 4, and 1 : 9) and ternary complexes with HPβCD and Tryp at 1 : 1 : 1, 1 : 1 : 0.27, 1 : 2.5 : 0.27, 1 : 3.6 : 3.6, 1 : 4 : 1, and 1 : 9 : 1, respectively. Complexes were prepared by the physical mixing (PM) and solvent evaporation (SE) methods.

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13

Fajriah, Sofa, Ilmi Fadhilah Rizki, and Ellya Sinurat. "Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera." Pharmacia 68, no. (4) (2021): 869–75. https://doi.org/10.3897/pharmacia.68.e73158.

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Caulerpa lentillifera is a type of green seaweed that is cultivated in tropical and subtropical areas. The objectives of this study were to determine the characteristics of the sulfated polysaccharides from C. lentillifera and evaluate its antidiabetic activity. In the initial process of this study, samples were macerated with ethanol (1:10). Then, the maceration residue was extracted with an accumulator at 75 °C for three hours. The crude extract yield was 4.16% based on weight seaweed. Ion chromatography purification with DEAE-Sepharose resin provided a yield of 14.8% of crude extract. The m

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Marina Silalahi. "Utilization and bioactivity of Ketepeng cina (Senna alata (L.) Roxb.)." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 012–17. http://dx.doi.org/10.30574/wjbphs.2022.12.1.0127.

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Senna alata (Fabaceae) has been long used by local people in Indonesia and other countries to treat various skin infections. This study aims to explain the relationship between the benefits and bioactivity of S. alata. The method used is library research on various research results published online at Google Scholar using the keywords Senna alata , uses of S. alata and S. alata bioactivity. The results obtained were synthesized to provide comprehensive information on the botanical, benefits and bioactivity of S. alata. Traditionally, S. alata is used to cure typhoid, diabetes, malaria, asthma,

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15

Yoon, Won-Joo, Hye-Ji Min, Hyun-Dong Cho, et al. "Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract." Biomedicines 12, no. 12 (2024): 2928. https://doi.org/10.3390/biomedicines12122928.

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Background: Euonymus alatus (E. alatus) has traditionally been used for medicinal purposes, and its leaves are considered edible. While E. alatus is known for its diverse biological activities, the antioxidant, antidiabetic, and anticancer effects of its leaves extracted using different solvents have not been thoroughly investigated. Methods: This study examined the antioxidant, antidiabetic, anticancer, and life-prolonging effects of Euonymus alatus (E. alatus) leaf extract. Results: The phytochemical analysis showed that the ethanol extract contained the highest levels of polyphenols (347.2

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Marina Silalahi. "Bioactivity and uses of Cnidoscolus aconitifolius (Mill.) I.M. Johnst." World Journal of Biology Pharmacy and Health Sciences 7, no. 3 (2021): 057–64. http://dx.doi.org/10.30574/wjbphs.2021.7.3.0097.

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Cnidoscolus aconitifolius has been long used by ethnic groups in Indonesia for vegetables and traditional medicine. This study aims to explain the benefits of C. aconitifolius for food and its bioactivity. The method for writing is library research on scientific articles published online at Google Scholar by using the keywords: uses of C. aconitifolius and bioactivity of C. aconitifolius. All available articles were synthesized to provide comprehensive information on C. aconitifolius for food and its bioactivity. C. aconitifolius has two to three times more nutrients than spinach, spinach, Chi

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17

Shashank, Shekhar Mishra, Gaur Rituraj, Sirvi Gajaram, Kumar Neeraj, Shekhar Sharma Chandra, and Pratap Singh Hamendra. "Computational Analysis of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Oral-hypoglycaemic Agents." Chemistry Research Journal 3, no. 2 (2018): 135–40. https://doi.org/10.5281/zenodo.13923564.

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Diabetes mellitus is a chronic, lifelong condition that affects body's ability to use the energy found in food. The number of patients with DM is markedly increasing worldwide. Globally the prevalence of diabetes mellitus is increasing. The increase in prevalence has accelerated due to the aging population structure in the developed countries and due to the globally increasing obesity, as well as stressing life style. Diabetes mellitus is the sixth leading cause of death globally. There are several medications associated adverse effects occur. So, there is essential requirement for developing

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18

Rauter, Amélia P., Alice Martins, Rui Lopes, et al. "Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera." Journal of Ethnopharmacology 122, no. 2 (2009): 384–93. http://dx.doi.org/10.1016/j.jep.2008.10.011.

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19

Azleen, A., Z. M. Taher, S. Sasano, T. Ariga, and A. A. Aziz. "Chemical constituents and bioactivity of Piper sarmentosum: a mini review." Food Research 4, S2 (2020): 14–18. http://dx.doi.org/10.26656/fr.2017.4(s2).s10.

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Herbs with medicinal potential are important for health and wellness. The main aim of this review article was to disseminate important information regarding the use of Piper sarmentosum as natural medicine. P. sarmentosum have been reported to possess a varying degree of hypoglycemic, antidiabetic and other additional properties. The antioxidant properties of the herbs may be effective in controlling the oxidative damage. The review article highlights the positive role of traditional herbs as alternative medicine.

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20

Jain, Vishal, G. L. Viswanatha, D. Manohar, and H. N. Shivaprasad. "Isolation of Antidiabetic Principle from Fruit Rinds ofPunica granatum." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/147202.

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Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds ofPunica granatum. With the above objectives Valoneic acid dilactone (VAD) was isolated from methanolic fruit rind extracts ofPunica granatum(MEPG) and confirmed by1H-NMR,13C-NMR, and mass spectral data. Antidiabetic activity was evaluated by Aldose reductase,α-amylase and PTP1B inhibition assays inin vitroand Alloxan-induced diabetes in rats was used as anin vivomodel. In bioactivity studies, MEPG and VAD have showed potent antidiabetic activity inα-amylase, aldose reductase, and PT

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21

Ariviani, S., L. C. Sasmita, L. N. Khusafa'ah, N. Ratnaningsih, and A. Yulviatun. "Na-alginate elicitation as an alternative strategy to improve the antidiabetic potential of pigeon pea (Cajanus cajan) flour." Food Research 6, no. 4 (2022): 246–53. http://dx.doi.org/10.26656/fr.2017.6(4).843.

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Pigeon pea (Cajanus cajan) has been reported to exhibit antidiabetic activity such as hypoglycemic and hypocholesterolemic effects as well as antioxidant capacity in diabetichypercholesterolemia rats, alpha-glucosidase and alpha-amylase inhibitory activity, due to the bioactive compounds. Germination proved capable to increases the antidiabetic activity of pigeon pea. Elicitation has been known as a simple method for increasing the bioactive compounds and bioactivity of legumes sprouts. This study aimed to investigate the potential of Na-alginate elicitation in improving the antidiabetic activ

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22

Tlhapi, Dorcas, Isaiah Ramaite, Chinedu Anokwuru, and Teunis van Ree. "Molecular Networking-Based Metabolome, In Vitro Antidiabetic and Anti-Inflammatory Effects of Breonadia salicina (Vahl) Hepper & J.R.I. Wood." Metabolites 14, no. 6 (2024): 291. http://dx.doi.org/10.3390/metabo14060291.

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Breonadia salicina (Vahl) Hepper & J.R.I. Wood is widely distributed throughout Africa. It is used ethnobotanically to treat various diseases. However, the metabolic profile of the Breonadia species is not well characterized and the metabolites that are responsible for the bioactivity of this plant remain unknown. Therefore, there is a need to determine the phytochemical and bioactivity profile to identify metabolites that contribute to the antidiabetic, anti-inflammatory and antiproliferation activity, including the genotoxicity and cytotoxic effects, of Breonadia salicina. The study is a

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23

Osman, Wadah, Mona S. Mohammed, Hassan S. Khalid, et al. "HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L." Advances in Pharmacological and Pharmaceutical Sciences 2020 (April 24, 2020): 1–18. http://dx.doi.org/10.1155/2020/3201463.

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Diabetes is one of the world’s major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass s

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Çiçek, Serhat S., Sara Vitalini, and Christian Zidorn. "Natural Phenyldihydroisocoumarins: Sources, Chemistry and Bioactivity." Natural Product Communications 13, no. 3 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300306.

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The present review gives an overview about naturally occurring phenyldihydroisocoumarins, their sources, and bioactivities. In total, 54 compounds are covered, including eight substances which are in fact alkaloids or protoalkaloids. These nitrogen containing compounds were exclusively found in the Papaveraceae family. The remaining 46 compounds have been reported from twelve different source families, ranging from mosses to angiosperms. Six of the nitrogen free compounds feature additional rings, while 40 are simple phenyldihydroisocoumarins with substituents in all possible positions, except

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Marina, Silalahi. "Utilization and bioactivity of Ketepeng cina (Senna alata (L.) Roxb.)." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 012–17. https://doi.org/10.5281/zenodo.7602032.

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<em>Senna alata</em> (Fabaceae) has been long used by local people in Indonesia and other countries to treat various skin infections. This study aims to explain the relationship between the benefits and bioactivity of <em>S. alata</em>. The method used is library research on various research results published online at Google Scholar using the keywords <em>Senna alata </em>, uses of <em>S. alata </em>and <em>S. alata </em>bioactivity. The results obtained were synthesized to provide comprehensive information on the botanical, benefits and bioactivity of&

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Rubio-Reyes, Aram Y., Iván Delgado-Enciso, Eduardo Casas, Estela Garza-Brenner, and Ana M. Sifuentes-Rincón. "Influence of the Casein Genotype on Goat Milk Bioactivity: An In Silico Analysis of the Casein Peptidome." Molecules 30, no. 12 (2025): 2601. https://doi.org/10.3390/molecules30122601.

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Goat caseins are highly polymorphic proteins that affect milk functional properties. In this study, an in silico approach was employed to analyze the influence of goat casein allelic variants on the quantity and bioactivity potential of peptides released after enzymatic hydrolysis. The reported protein sequences from the most frequent allelic variants in Capra hircus caseins (α-S1, β, α-S2, and κ-casein) were analyzed in the BIOPEP-UWM database to determine the frequency of occurrence of bioactive fragments from each casein. After specific hydrolysis with pepsin, trypsin, and chymotrypsin A, i

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Bharathy, Pavithra, Silpa Jayaprakash, Allen Christopher M, Rajini prem G, and Punniyakoti Veeraveedu Thanikachalam. "Characterization and cytotoxicity evaluation of Ixora coccinea-derived iron oxide microparticles for biomedical applications." Journal of Applied Pharmaceutical Research 13, no. 1 (2025): 179–90. https://doi.org/10.69857/joapr.v13i1.870.

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Background: This study aimed to synthesise and characterise iron oxide microparticles (IOMPs) using Ixora coccinea flower extracts and evaluate their antioxidant, anti-inflammatory, cytotoxic, and antidiabetic activities. Methodology: IOMPs were synthesised using Ixora coccinea flower extract and characterised using XRD, UV-Vis, EDAX APEX, and SEM. Bioactivity evaluations included anti-inflammatory and antioxidant activities via egg albumin, BSA, and DPPH assays; cytotoxicity through Brine Shrimp Lethality and zebrafish embryonic toxicity assays at 5, 10, 20, 40, and 80 μg/ml; and antidiabetic

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28

Sarian, Murni Nazira, Qamar Uddin Ahmed, Siti Zaiton Mat So’ad, et al. "Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study." BioMed Research International 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8386065.

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The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evalu

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Montero, Lidia, Andrea del Pilar Sánchez-Camargo, Elena Ibáñez, and Bienvenida Gilbert-López. "Phenolic Compounds from Edible Algae: Bioactivity and Health Benefits." Current Medicinal Chemistry 25, no. 37 (2019): 4808–26. http://dx.doi.org/10.2174/0929867324666170523120101.

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Algae have been consumed for many years in Asian countries; at present, its consumption around the world either as food ingredient or directly as food commodity has increased considerably mainly due to the Asian influence and its cuisine, but also because of the growing interest in the beneficial health effects of algae. Although several biological activities have been attributed to different algae compounds such as pigments, lipids, polysaccharides, fiber, proteins or vitamins, in the present review we will highlight the different phenolic compounds present on seaweeds and their important rol

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Abdou, Wafaa M., Neven A. Ganoub, and Reham F. Barghash. "Synthesis and Bioactivity of Benzothiazaphosphepines and Relevant Phosphonates as Antioxidant/Antidiabetic Agents." Synthetic Communications 44, no. 18 (2014): 2669–78. http://dx.doi.org/10.1080/00397911.2014.912329.

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Shams Eldin, Safa M., Mohamed M. Radwan, Amira S. Wanas, et al. "Bioactivity-Guided Isolation of Potential Antidiabetic and Antihyperlipidemic Compounds from Trigonella stellata." Journal of Natural Products 81, no. 5 (2018): 1154–61. http://dx.doi.org/10.1021/acs.jnatprod.7b00707.

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Khan, Mohammad Faheem, Arun Kumar Rawat, Bhawna Pawar, Sudeep Gautam, Arvind Kumar Srivastava, and Devendra Singh Negi. "Bioactivity-guided chemical analysis of Melia azedarach L. (Meliaceae), displaying antidiabetic activity." Fitoterapia 98 (October 2014): 98–103. http://dx.doi.org/10.1016/j.fitote.2014.07.014.

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33

Marina, Silalahi. "Bioactivity and uses of Cnidoscolus aconitifolius (Mill.) I.M. Johnst." World Journal of Biology Pharmacy and Health Sciences 7, no. 3 (2021): 057–64. https://doi.org/10.5281/zenodo.5543043.

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<em>Cnidoscolus aconitifolius</em> has been long used by ethnic groups in Indonesia for vegetables and traditional medicine. This study aims to explain the benefits of <em>C. aconitifolius</em> for food and its bioactivity. The method for writing is library research on scientific articles published online at Google Scholar by using the keywords: uses of <em>C. aconitifolius</em> and bioactivity of C<em>. aconitifolius</em>. All available articles were synthesized to provide comprehensive information on <em>C. aconitifolius</em> for food and its bioactivity.&n

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Awwad, Abdulmomem, Patrick Poucheret, Yanis A. Idres, et al. "In Vitro Tests for a Rapid Evaluation of Antidiabetic Potential of Plant Species Containing Caffeic Acid Derivatives: A Validation by Two Well-Known Antidiabetic Plants, Ocimum gratissimum L. Leaf and Musanga cecropioides R. Br. ex Tedlie (Mu) Stem Bark." Molecules 26, no. 18 (2021): 5566. http://dx.doi.org/10.3390/molecules26185566.

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Plant bioactive extracts represent a major resource for identifying drugs and adjuvant therapy for type 2 diabetes. To promote early screening of plants’ antidiabetic potential, we designed a four in vitro tests strategy to anticipate in vivo bioactivity. Two antidiabetic plants were studied: Ocimum gratissimum L. (Oc) leaf extract and Musanga cecropoides R. Br. ex Tedlie (Mu) stem bark extract. Chemical compositions were analyzed by LCMS and HPLC. Antidiabetic properties were measured based on (1) INS-1 cells for insulin secretion, (2) L6 myoblast cells for insulin sensitization (Glut-4 trans

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Prima, Sylvia Rizky, Elfahmi, Elin Julianti, and Irda Fidrianny. "Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L." Pharmacia 70, no. (3) (2023): 717–24. https://doi.org/10.3897/pharmacia.70.e99666.

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Allium cepa L. is commonly used as a vegetable, spice, and in traditional medicine. In traditional medicine, A. cepa is applied based on its long-standing usage. This plant has been reported to have therapeutic effects on various conditions, including diabetes, various types of cancer, cough, influenza, dermatological problems, diarrhea, menstrual and abdominal pain, and malaria. Phytochemical analysis of A. cepa has identified polyphenols, flavonoids, steroid saponins, furostanol saponins, and sulfur compounds, which are believed to be responsible for its bioactivities. These bioactivities in

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Aremu, Abdulfatai, Olayinka A. Oridupa, Ganiu J. Akorede, Afisu Basiru, and Akeem O. Ahmed. "In Vivo Bioactivity-Guided Fractions and Compounds Isolation of Antidiabetic Activities of Lawsonia Inermis Linn Leaves in Streptozocine Induced Diabetic Wistar Rats." Indiana Journal of Agriculture and Life Sciences 2, no. 5 (2022): 53–61. https://doi.org/10.5281/zenodo.7267429.

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<strong>Abstract:</strong> Diabetes mellitus (DM) is a chronic metabolic disorder affecting substantial percentage of the world populace. Conventional treatments for DM have many limitations in terms of side effects and high rates of secondary failure. Antidiabetic effect of crude <em>Lawsonia inermis</em> Linn. leaves have been reported. Nevertheless, bioactive fraction and compounds accountable for the antidiabetic effect needs to be isolated for possible drug candidate. Thus, this study was designed to isolate the antidiabetic fraction and compounds of <em>Lawsonia inermis</em> Linn. leaves

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Nahar, Lutfun, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul, and Satyajit D. Sarker. "Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential." Molecules 26, no. 6 (2021): 1609. http://dx.doi.org/10.3390/molecules26061609.

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Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiproto

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Silalahi, Marina. "HUBUNGAN PEMANFAATAN TUMBUHAN PASAK BUMI (Eurycoma longifolia Jack.) SEBAGAI OBAT TRADISIONAL DAN BIOAKTIVITASNYA." Jurnal Pendidikan Matematika dan IPA 10, no. 2 (2019): 109. http://dx.doi.org/10.26418/jpmipa.v10i2.31025.

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Pasak bumi (Eurycoma longifolia Jack.) is a species belonging Simarobuaceae has been long used as traditional medicine, which known very well as aphrosidiac. The studies have been conducted to reveal the benefits of E. longifolia through ethnobotany, phytochemical, and bioessay approaches, but the review articles on the its utilization and bioactivity limited. This article is based on scientific articles published on line or off-line, then synthesized so that to be information the relationship between use and bioactivity. Ethnobotany of E. longifolia have been used as a medicine for fever, mal

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Fajriah, Sofa, Ilmi Fadhilah Rizki, and Ellya Sinurat. "Characterization and analysis of the antidiabetic activities of sulphated polysaccharide extract from Caulerpa lentillifera." Pharmacia 68, no. 4 (2021): 869–75. http://dx.doi.org/10.3897/pharmacia.68.e73158.

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Caulerpa lentillifera is a type of green seaweed that is cultivated in tropical and subtropical areas. The objectives of this study were to determine the characteristics of the sulfated polysaccharides from C. lentillifera and evaluate its antidiabetic activity. In the initial process of this study, samples were macerated with ethanol (1:10). Then, the maceration residue was extracted with an accumulator at 75 °C for three hours. The crude extract yield was 4.16% based on weight seaweed. Ion chromatography purification with DEAE-Sepharose resin provided a yield of 14.8% of crude extract. The m

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Wang, Xiyue, Qingyun Hu, Hui Tang, and Xinhui Pan. "Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review." Pharmaceuticals 16, no. 2 (2023): 228. http://dx.doi.org/10.3390/ph16020228.

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Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.

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Bokor, Éva, Sándor Kun, David Goyard, et al. "C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential." Chemical Reviews 117, no. 3 (2017): 1687–764. http://dx.doi.org/10.1021/acs.chemrev.6b00475.

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Nyberg, NT, SG Wubshet, KT Kongstad, and D. Staerk. "Ligand-fishing and bioactivity-correlated metabolomics for accelerated discovery of antidiabetic drug leads." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596175.

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Ibitoye, O. B., K. A. Olofinsan, K. Teralı, U. M. Ghali, and T. O. Ajiboye. "Bioactivity-guided isolation of antidiabetic principles from the methanolic leaf extract ofBryophyllum pinnatum." Journal of Food Biochemistry 42, no. 5 (2018): e12627. http://dx.doi.org/10.1111/jfbc.12627.

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Ji, Wenduo, Lixia Gu, Xuezhe Zou, et al. "Discovery, Validation, and Target Prediction of Antibacterial and Antidiabetic Components of Archidendron clypearia Based on a Combination of Multiple Analytical Methods." Molecules 28, no. 3 (2023): 1329. http://dx.doi.org/10.3390/molecules28031329.

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Archidendron clypearia (A. clypearia), a Fabaceae family member, is widely used as an anti-inflammatory herbal medicine; however, its antibacterial and antidiabetic properties have not been extensively investigated. This study aimed to systematically analyze the antibacterial and antidiabetic components of A. clypearia by utilizing a combination of analytical methods. First, ten different polarity extracts were analyzed through ultra-performance liquid chromatography (UPLC), and their antibacterial and antidiabetic activities were evaluated. Then the spectrum–effect relationship between the bi

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Ananto, Agus Dwi. "Studi In Silico Bioaktivitas Antikanker Senyawa Aktif Dalam Minyak Biji Buah Wali [Brucea javanica (L.) Merr]." Sasambo Journal of Pharmacy 1, no. 2 (2020): 26–29. http://dx.doi.org/10.29303/sjp.v1i2.13.

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Insilico study of anticancer bioactivity in oil of “buah wali” [Brucea javanica (L.) Merr] has been successfully carried out. “Buah Wali” (Brucea javanica (L.) Merr) is known to treat various diseases such as diabetes, diarrhea, and malaria. In addition, “buah wali” seeds are supported to have antidiabetic, antioxidant, and anticancer activities. The stages of the study began by taking a sample of “buah wali”seeds, then extracted to get oil of “buah wali”. While GC-MS analysis resulted Octadec-9-enoic acid (56.25%), palmitic acid (13.82%), stearic acid (10.57%), and acids -9-octadecanoate (5.9

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M., CHAKRABARTY, and KHASNOBIS S. "A Brief Survey of the Synthesis and Bioactivity of Pyrrolocarbazoles, an Emerging Class of Condensed Heterocycles." Journal of Indian Chemical Society Vol. 74, Nov-Dec 1997 (1997): 917–25. https://doi.org/10.5281/zenodo.5900659.

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Department of Chemistry, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Calcutta-700 009 <em>Manuscript received 15 September 1997</em> Pyrrolocarbazoles arising out of the condensation of the a, b and c bonds of carbazoles and 2,3 and 3,4 bonds of pyrroles have been recently synthesized by different routes, the Diets-Alder cyclization being the prbne avenue. One pyrrolocarbazole has also been isolated from a marine sponge. Many of these compounds display a variety of bioactivities including anticancer, antidiabetic, neurotrophic and protein kinase inhibitory properties. The reported syn

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Widiastuti, Diana, Siska Elisahbet Sinaga, Siti Warnasih, Erna Pujiyawati, Supriatno Salam, and Wira Eka Putra. "Identification of Active Compounds from Averrhoa bilimbi L. (Belimbing Wuluh) Flower using LC-MS and Antidiabetic Activity Test using in vitro and in silico Approaches." Trends in Sciences 20, no. 8 (2023): 6761. http://dx.doi.org/10.48048/tis.2023.6761.

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Averrhoa bilimbi L., (Belimbing wuluh), is traditionally used for various antidiabetic, anti-larvicidal, antioxidant, hypoallergenic, antibacterial, antifungal, and anti-inflammatory treatments. This study evaluated 3 extracts (n-hexane, ethyl acetate, and n-butanol) isolated from starfruit flowers for antidiabetic effects using in vitro and in silico methods. Ethyl acetate extract showed the highest activity, followed by n-hexane and n-butanol extracts in inhibiting α-glucosidase. Each extract has an IC50 value of 89.84, 52.88, and 114.86 µg/mL. The active compounds contained in the ethyl ace

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Wulandari, Putri, and Elsa Yuniarti. "Bioactivity Potential and Chemical Compounds of Cinnamomum: Literature Review." Jurnal Penelitian Pendidikan IPA 9, no. 5 (2023): 1–7. http://dx.doi.org/10.29303/jppipa.v9i5.3284.

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Cinnamon is a spice commodity that contains chemical compounds and bioactive components that have the potential to be developed as medicinal raw materials in the pharmaceutical industry. Biological activity in cinnamon can increase and stimulate the body's immune system. This study aims to present a summary of the literature review to unify the overall information on bioactivity and chemical compound content in cinnamon. The research method uses the literature review method with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) meta-analysis approach. The literatur

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Alam, Perwez, Mohd Imran, Shahnawaz Ahmed, Haya Majid, and Ali Akhtar. "Chitosan Nanoparticles for Enhanced Delivery of Sida cordifolia Extract: Formulation, Optimization and Bioactivity Assessment." Pharmaceuticals 16, no. 11 (2023): 1561. http://dx.doi.org/10.3390/ph16111561.

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In a continuous search for an essential antidiabetic agent, Sida cordifolia hydroalcoholic (SCHA) extract-loaded chitosan nanoparticles (SCHA-CS-NP) were optimized. The Box–Behnken design (BBD Design-Expert software, version 14) with three parameters was used to optimize the nanoparticles after creating them using the ion gelation method. The chitosan and Tween 20 contents and the stirring speed were chosen as the independent variables, and their separate and combined effects on particle size (Y1), polydispersity index (Y2) and entrapment efficiency (Y3) were observed. The optimized formulatio

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Budaya, Andin Tasyalia, Putri Ramadhani Kaharuddin, Aisyah Aulia Said, et al. "Enhancing antidiabetic bioactivity of purslane leaf extract (Portulaca oleracea L.) through synthesis of nanoemulsion: In vitro and in vivo evidence." Journal of Research in Pharmacy 29, no. 3 (2024): 1007–16. https://doi.org/10.12991/jrespharm.1694160.

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Purslane plant (Portulaca oleracea) is a type of herbal plant that can be used in traditional diabetes treatment because it has the highest content of the quercetin found in the leaves which plays a role in inhibiting the α-amylase enzyme. However, it is less active due to limitations in drug solubility and delivery. Therefore, we developed a nanoemulsion of purslane leaf extract as an antidiabetic in vitro through α-amylase enzyme inhibition and in vivo through alloxan induction. The nanoemulsion was made using virgin coconut oil as the oil phase, polysorbate as the surfactant, propylene glyc

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