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Journal articles on the topic 'Antidiabetic products'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Alam, Fahmida, Md Asiful Islam, Mohammad Amjad Kamal, and Siew Hua Gan. "Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development." Current Medicinal Chemistry 25, no. 39 (2019): 5395–431. http://dx.doi.org/10.2174/0929867323666160813222436.

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Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are current

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Ogunlakin, Akingbolabo Daniel, Taiwo Rukayat Onifade, Oluwafemi Adeleke Ojo, et al. "Antidiabetic potential of Carica papaya L. and its constituents: From folkloric uses to products development." Bioactive Compounds in Health and Disease 6, no. 6 (2023): 126. http://dx.doi.org/10.31989/bchd.v6i6.1108.

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Carica papaya L. is a plant that has a reputation for being antidiabetic. This review is focused on antidiabetic properties of Carica papaya. A comprehensive search was performed using various electronic databases including Researchgate, PubMed, Google Scholar, Biomedgrid.com and ScienceDirect. 224 publications were downloaded, out of which one 107 relevant publications were reviewed. The fruit, leaves, and seeds of this plant have been reported to possess antidiabetic properties at different dosages via in vivo, in vitro, and ex vivo studies. Fortified papaya cake, MPPB flour (containing C. p

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Weidner, C., J. C. de Groot, A. Prasad, et al. "Amorfrutins are potent antidiabetic dietary natural products." Proceedings of the National Academy of Sciences 109, no. 19 (2012): 7257–62. http://dx.doi.org/10.1073/pnas.1116971109.

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4

Oetjen, E. "Amorfrutins are potent antidiabetic dietary natural products." Yearbook of Endocrinology 2013 (2013): 25. https://doi.org/10.1016/j.yend.2013.03.036.

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Tabassum, Nadia, Hongmei Tai, Da-Woon Jung, and Darren R. Williams. "Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–16. http://dx.doi.org/10.1155/2015/287847.

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Diabetes mellitus affects millions of people worldwide and significantly impacts their quality of life. Moreover, life threatening diseases, such as myocardial infarction, blindness, and renal disorders, increase the morbidity rate associated with diabetes. Various natural products from medicinal plants have shown potential as antidiabetes agents in cell-based screening systems. However, many of these potential “hits” fail in mammalian tests, due to issues such as poor pharmacokinetics and/or toxic side effects. To address this problem, the zebrafish (Danio rerio) model has been developed as a

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Shah, Erum. "Studies on antidiabetic herbal formulations available in the herbal stores of Karachi, Pakistan." Journal of Pharmacy & Pharmacognosy Research 10, no. 2 (2022): 349–56. http://dx.doi.org/10.56499/jppres21.1203_10.2.349.

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Context: Diabetes mellitus is a condition, which is characterized by persistent hyperglycemia, abnormal functioning of insulin and difficulty in the metabolism of carbohydrates, fats and proteins. Antidiabetic medicines of herbal origin are widely consumed in Pakistan. Therefore, there was a need to generate data on antidiabetic herbal formulations manufactured and marketed in Pakistan. Aims: To develop a list of Pakistani manufactured antidiabetic herbal products and the most common herbal ingredients found in them. Methods: Antidiabetic herbal formulations were collected from the renowned he

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COMAN, Cristina, Olivia Dumitrita RUGINA, and Carmen SOCACIU. "Plants and Natural Compounds with Antidiabetic Action." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 40, no. 1 (2012): 314. http://dx.doi.org/10.15835/nbha4017205.

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synt

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Rais, Ichwan Ridwan, Andhika Septiawan, Meta Ayuni, Dhega Agung Wichaksono, and Nanik Sulistyani. "The antioxidant activity of several antidiabetic herbal products." Pharmaciana 12, no. 2 (2022): 253. http://dx.doi.org/10.12928/pharmaciana.v12i2.22714.

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9

Chua, Lee Suan. "Bioactive compounds from natural products with antidiabetic potentials." Longhua Chinese Medicine 5 (March 2022): 1. http://dx.doi.org/10.21037/lcm-21-64.

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10

Osadebe, Patience, Estella Odoh, and Philip Uzor. "Natural Products as Potential Sources of Antidiabetic Drugs." British Journal of Pharmaceutical Research 4, no. 17 (2014): 2075–95. http://dx.doi.org/10.9734/bjpr/2014/8382.

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11

Abdul Radzak, Hazirah, Abdah Md Akim, Norshariza Nordin, et al. "Omics-Based Approaches for Investigation the Mechanistic Action of Natural Products as Anti- diabetic Agents: A Comprehensive Review." ASM Science Journal 20, no. 1 (2025): 1–12. https://doi.org/10.32802/asmscj.2025.1859.

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With the rising prevalence of diabetes mellitus (DM), the search for novel antidiabetic agents has become increasingly urgent. In the past two decades, there has been a significant shift toward exploring natural products as viable alternatives to synthetic antidiabetic drugs, which often come with undesirable side effects. Researchers have employed various methodologies to uncover the antidiabetic potential of these natural products, focusing on their mechanisms of action and molecular targets involved in DM pathogenesis. Advancements in high-throughput technologies have propelled omics- based

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12

Raj, Kanwal, Namita Misra, Geetali Pachauri, et al. "Novel class of hybrid natural products as antidiabetic agents." Natural Product Research 23, no. 1 (2009): 60–69. http://dx.doi.org/10.1080/14786410701824940.

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13

Peneva, Anna, Milen Dimitrov, and Valentina Petkova. "Comparative analysis of newer classes of antidiabetics and the concept of pharmaceutical care – dealing with therapeutic problems." Pharmacia 71, no. () (2024): 1–8. https://doi.org/10.3897/pharmacia.71.e120141.

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The prevalence of obesity is increasing rapidly. The latest World Health Organization – WHO report declares the disease as an epidemic. After pharmacodynamic, pharmacokinetic, clinical and pharmacoepidemiologic data analysis and comparison of the three classes of antidiabetic medicinal products: GLP-1 receptor agonists, DPP-4 inhibitors and SGLT2 inhibitors, a literature review of the topic, patient education and the concept of pharmaceutical care emerged as methods for dealing with the most common adverse drug reactions, safety concerns, and drug interactions.

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Saraswati, Kartika, Chanvilay Sichanh, Paul N. Newton, and Céline Caillet. "Quality of medical products for diabetes management: a systematic review." BMJ Global Health 4, no. 5 (2019): e001636. http://dx.doi.org/10.1136/bmjgh-2019-001636.

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BackgroundThe global prevalence of diabetes mellitus is increasing alarmingly. However, the quality of vital medicines and medical products used to treat and monitor diabetes remains uncertain but of potential great public health significance. Here, we review the available evidence on the quality of antidiabetic medicines and supplies for self-monitoring of blood glucose (SMBG) and discuss their potential impact for the patients and society.MethodsSearches were conducted in PubMed, Embase, Google Scholar, Google and relevant websites in English and French. The Medicine Quality Assessment Repor

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15

Zaki, Muthanna K., Mohammed N. Abed, and Fawaz A. Alassaf. "Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations." Journal of Bone Metabolism 31, no. 3 (2024): 169–81. http://dx.doi.org/10.11005/jbm.2024.31.3.169.

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Diabetes mellitus is associated with inadequate bone health and quality and heightened susceptibility to fractures, even in patients with normal or elevated bone mineral density. Elevated advanced glycation end-products (AGEs) and a suppressed incretin pathway are among the mechanisms through which diabetes affects the bone. Accordingly, the present review aimed to investigate the effects of antidiabetic medications on bone quality, primarily through AGEs and the incretin pathway. Google Scholar, Cochrane Library, and PubMed were used to examine related studies until February 2024. Antidiabeti

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Francini, Flavio, Guillermo R. Schinella, and José-Luis Ríos. "Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus." Mini-Reviews in Medicinal Chemistry 19, no. 11 (2019): 880–901. http://dx.doi.org/10.2174/1389557519666181128120726.

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Type-2 Diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. In fact,

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Kwon, Dae Young, James W. Daily, Hyun Jin Kim, and Sunmin Park. "Antidiabetic effects of fermented soybean products on type 2 diabetes." Nutrition Research 30, no. 1 (2010): 1–13. http://dx.doi.org/10.1016/j.nutres.2009.11.004.

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18

Rosenzweig, Tovit, and Sanford R. Sampson. "Activation of Insulin Signaling by Botanical Products." International Journal of Molecular Sciences 22, no. 8 (2021): 4193. http://dx.doi.org/10.3390/ijms22084193.

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Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. However, despite the impressive success in the development of new antidiabetic drugs, almost no progress has been achieved with regard to the development of novel insulin-sensitizing agents. As insulin resistance is the most eminent factor in the patho-etiology of T2D, it is not surprising that an alarming number of patients still fail to m

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19

Bansode, Twinkle Sunder, and B. K. Salalkar. "Phytotherapy: Herbal medicine in the management of Diabetes mellitus." Plant Science Today 4, no. 4 (2017): 161–65. http://dx.doi.org/10.14719/pst.2017.4.4.347.

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Despite considerable progress in the treatment of the diabetes with synthetic drugs, the search for effective, safe and inexpensive drugs is ongoing from herbs, since they offer a wide range of antidiabetic agents. Antidiabetic studies using in silico, in vitro and in vivo aspect of different medicinal plant products (Trigonella foenum-graecum, seeds; Syzygium cumini, seeds; Salvadora persica, leaves and Terminalia chebula, seeds) were reviewed. The objective of the study was to compare these medicinal plants for their hypoglycemic effect and phytochemical composition in order to find out most

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20

Laware, Ravindra B., Shubhangi P. Pulate, Santosh B. Dighe, and Sanjay B. Bhawar. "Formulation Development and Evaluation of Leaf Extract of Ficus benghalensis for Antidiabetic Activity." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 611–14. http://dx.doi.org/10.22270/jddt.v9i3-s.2919.

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Herbal products are known for their inherent property i.e. comparatively safe and economic. In present study, leaf extract of ficus benghalensis was evaluated for antidiabetic activity. The aim of the research work was to formulate and evaluate capsule dosage form of ethanolic extract. Leaves of Ficus benghalensis collected from local area of Ahmednagar district and shade dried. Ethanolic, Hydroalcoholic and petroleum ether extracts were prepared using soxhlet apparatus. Extracts were screened for antidiabetic activity using alloxan induced diabetes in rats. Oral glucose tolerance test was mea

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Sousa, Leonardo da Rocha, Celma de Oliveira Barbosa, Nildomar Ribeiro Viana, aria do Carmo de Carvalho e Martins, Ricardo Martins Ramos, and Daniel Dias Rufino Arcanjo. "R-(+)-Limoneno e seu derivado (–)-Carveol: uma revisão de seus efeitos sobre o diabetes." Somma: Revista Científica do Instituto Federal de Educação, Ciência e Tecnologia do Piauí 9 (January 10, 2023): 1–21. http://dx.doi.org/10.51361/somma.v9i1.134.

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Diabetes is a metabolic disorder of multiple etiologies, which is mainly characterized by persistently high levels of glucose in the blood. Estimates from the World Health Organization (WHO) indicate that approximately 422 million people have diabetes and 1.6 million deaths are directly attributed to the disease each year. Faced with such relevant numbers, natural therapies are sought that are effective, efficient and low-cost for the referred pathology. Several natural products are already being used as adjuvants in the treatment of diabetes because they have hypoglycemic action, such as mono

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22

Lock, Adam L., Phil C. Garnsworthy, Benjamin A. Corl, and Dale E. Bauman. "Dietary manipulation of conjugated linoleic acid in ruminant products." Proceedings of the British Society of Animal Science 2003 (2003): 219–20. http://dx.doi.org/10.1017/s1752756200013776.

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Conjugated linoleic acid (CLA) is a collective term used to represent positional and geometric isomers of linoleic acid with conjugated double bonds. CLAs have been reported to have a wide range of beneficial effects, including: anticarcinogenic, antiatherogenic, antidiabetic and immune stimulatory. They have been shown to alter nutrient partitioning and lipid metabolism, and reduce body fat in a number of different animal species.

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23

Azab, Abdullatif. "Top Edible Wild Plants of Eastern Mediterranean Region. Part III: Antidiabetic Activity." European Journal of Medicinal Plants 34, no. 9 (2023): 84–107. http://dx.doi.org/10.9734/ejmp/2023/v34i91160.

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In the first two parts of this series of review articles, we presented the anticancer and anti-inflammatory activities of the most important wild edible plants of eastern Mediterranean region, which we named as the “Deca-plants” (D-P). In this review article, we will present the antidiabetic activities of these very important plants. Comparing with anticancer and anti-inflammatory activities, the overall antidiabetic activity of the D-P is moderate, but there are clear differences between the ten species. Based on this fact and on the knowledge that the D-P contain several natural products wit

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Prerana. M. Khamkar, Prerana M. Khamkar, Aboli V. Mahadik Aboli. V. Mahadik, A. P. Jadhav A. P. Jadhav, and V. K. Redasani V. K. Redasani. "Comparative study on antidiabetic drugs of different companies." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1710–013. https://doi.org/10.35629/4494-100217101713.

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The pharmaceutical sector is rapidly adapting to changing market situations, technical breakthroughs, and regulatory landscapes. This article examines pharmaceutical businesses' marketing strategies and challenges in a constantly evolving market.Because the products in question are different from general marketing, pharmaceutical marketing is essential to the healthcare ecosystem. Pharmaceuticals, as opposed to consumer goods, include over-the-counter (OTC) medications, life-saving prescriptions, and medical equipment; these products are all used to meet essential healthcare needs rather than

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25

Chakraborty, Prasanta. "Gene Clusters from Plants to Microbes: Their Role in Specialized Metabolism and Drug Development." International Journal of Pharmacognosy & Chinese Medicine 2, no. 5 (2018): 1–2. http://dx.doi.org/10.23880/ipcm-16000149.

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26

Konieczynski, Pawel, Monika Gappa, Marek Wesolowski, Edgar Pinto, and Agostinho Almeida. "Trace Elements in Medicinal Plants Traditionally Used in the Treatment of Diabetes—Do They Have a Role in the Claimed Therapeutic Effect?" Foods 11, no. 5 (2022): 667. http://dx.doi.org/10.3390/foods11050667.

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Background: Medicinal plants are often used in the treatment of diabetes mellitus, although knowledge about their mode of action and the substances responsible for their antidiabetic potential is limited. It is well known that some trace elements play a role in glucose metabolism and insulin action. Thus, a particular trace elements profile could be associated with the antidiabetic properties observed for some medicinal plants. Methods: Infusions (n = 102) prepared from commercial herbal products (n = 34) containing medicinal plants indicated for the treatment of diabetes (n = 16 different pla

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Assaggaf, Hamza, Naoufal El Hachlafi, Mohamed El fadili, et al. "GC/MS Profiling, In Vitro Antidiabetic Efficacy of Origanum compactum Benth. Essential Oil and In Silico Molecular Docking of Its Major Bioactive Compounds." Catalysts 13, no. 11 (2023): 1429. http://dx.doi.org/10.3390/catal13111429.

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Diabetes is a global health concern with significant implications for individuals and healthcare systems. Finding effective and safe antidiabetic agents is crucial for the management of this chronic disease. Natural products have emerged as potential alternatives to allopathic drugs, offering a vast source of bioactive compounds. In this study, we conducted an assessment of the antidiabetic potential of Origanum compactum essential oil, employing a two-pronged approach, i.e., experimental investigation and computational docking analysis. The results of gas chromatography–mass spectrometry (GC-

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Muema, Felix Wambua, Consolata Nanjala, Millicent Akinyi Oulo, and Phurpa Wangchuk. "Phytochemical Content and Antidiabetic Properties of Most Commonly Used Antidiabetic Medicinal Plants of Kenya." Molecules 28, no. 20 (2023): 7202. http://dx.doi.org/10.3390/molecules28207202.

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Traditional medicinal plants have been used for decades in folk medicines in the treatment and management of several ailments and diseases including diabetes, pain, ulcers, cancers, and wounds, among others. This study focused on the phytochemical and antidiabetic activity of the commonly used antidiabetic medicinal species in Kenya. Phytochemical profiling of these species revealed flavonoids and terpenoids as the major chemical classes reported which have been linked with strong biological activities against the aforementioned diseases, among others. However, out of the selected twenty-two s

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Ulfah, Ulfah, Haniza Hanim Mohd Zain, and Arfianti Arfianti. "Bibliometric Analysis of Global Research Trends on Plant Extract in Antidiabetic Research Using the Scopus Database." Journal of Science and Mathematics Letters 12, no. 2 (2024): 134–41. http://dx.doi.org/10.37134/jsml.vol12.2.10.2024.

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Natural products have been found to have antidiabetic effects in a growing number of studies, making them a popular topic in antidiabetic research. However, only a small number of bibliometric analyses have been extensively studied in this sector. This paper sought to examine the present state of plant extract research and provide emerging trends in the field. Research papers on natural remedies for diabetes were taken from the Scopus core collection database. The studies were analyzed and plotted using Mendeley and VOSviewer. The findings of this investigation indicate that 2.190 records of p

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Uzor, Philip F., Patience O. Osadebe, and Ngozi J. Nwodo. "Antidiabetic Activity of Extract and Compounds from an Endophytic Fungus Nigrospora oryzae." Drug Research 67, no. 05 (2017): 308–11. http://dx.doi.org/10.1055/s-0042-122777.

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AbstractThe fungal extract as well as the 3 biosynthetic compounds, (S)-(+)-2-cis-4-trans-abscisic acid (1), , 7'-hydroxy-abscisic acid (2) and 4-des-hydroxyl altersolanol A (3) from the endophytic fungus, Nigrospora oryzae, isolated from Combretum dolichopetalum leaf were investigated for their antidiabetic potential.The antidiabetic activity was determined in alloxan-induced diabetic mice by monitoring their fasting blood sugar for 9 h.The extract and the compounds (1–3) significantly (p<0.001) reduced the fasting blood sugar of the diabetic mice.The present study has shown that the biosy

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Rizvi, Syed Ibrahim, and Neetu Mishra. "Traditional Indian Medicines Used for the Management of Diabetes Mellitus." Journal of Diabetes Research 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/712092.

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Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization, up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show antidiabetic potential. The present review is aimed at providing in-depth information about the antidiabetic potential and bioactive compounds present inFicus religiosa, Pteroc

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Ivorra, M. D., M. Payá, and A. Villar. "A review of natural products and plants as potential antidiabetic drugs." Journal of Ethnopharmacology 27, no. 3 (1989): 243–75. http://dx.doi.org/10.1016/0378-8741(89)90001-9.

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Swain, Ayusman. "Antidiabetic Properties of Natural Products of Cyperus Species Plants: A Review." Indian Journal of Pharmaceutical Education and Research 57, no. 2s (2023): s226—s233. http://dx.doi.org/10.5530/ijper.57.2s.26.

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Nazreen, Syed. "Ethnomedicinal uses, Pharmacological and Phytochemical Studies of Bambusa arundinaceae Retz (A Review)." Oriental Journal Of Chemistry 38, no. 2 (2022): 247–58. http://dx.doi.org/10.13005/ojc/380204.

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Medicinal plants are a source of different types of natural products which are used in different illness. Bambusa arundinacea, commonly known as Bamboo belongs to family Poaceae (Gramineae). In folk medicine, it has been utilized for various inflammatory disorder, strangury, wounds, piles, dislodgement of worms, cirrhosis, hard tumour and diabetes mellitus. This plant possess antiinflammatory, antidiabetic, antimicrobial, antioxidant, anticancer, antiglycation, laxative, antifertility, antihelmintic, insecticidal, antiarthritic and neuroprotective activities. B. arundinacea extract has also be

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Lahlou, Radhia Aitfella, Filomena Carvalho, Maria João Pereira, João Lopes, and Luís R. Silva. "Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential." Pharmaceutics 16, no. 4 (2024): 454. http://dx.doi.org/10.3390/pharmaceutics16040454.

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The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic appl

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Lakshmi, Vijai, Abbas Ali Mahdi, Mohammad Kaleem Ahmad, Santosh Kumar Agarwal, and Arvind Kumar Srivastava. "Antidiabetic Activity of Lupeol and Lupeol Esters in Streptozotocin- Induced Diabetic Rats." Bangladesh Pharmaceutical Journal 17, no. 2 (2015): 138–46. http://dx.doi.org/10.3329/bpj.v17i2.22330.

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Currently, natural products have been shown to present interesting biological and pharmacological activities and are also used as chemotherapeutic agents. Plants have been used in treating cancer, cardiovascular disorders, tuberculosis and many other diseases. Therefore, the current study was designed to evaluate the antidiabetic potential of lupeol and its semisynthetic derivatives to get a new and potent antidiabetic agent. The ethanol extract of Crataeva nurvala, its hexane and chloroform soluble fractions and lupeol isolated from the extractives were evaluated.. Lupeol derivatives were pre

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Kury, Lina T. Al. "The KATP Channel is a Potential Target for Natural Plant Products in Type 2 Diabetes Mellitus." Diabetes & Obesity International Journal 5, no. 1 (2020): 1–9. http://dx.doi.org/10.23880/doij-16000219.

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Diabetes mellitus (DM) is a chronic metabolic disorder affecting a vast number of people all around the world. Diabetes is mainly characterized by chronic hyperglycemia, resulting from defects in insulin secretion or insulin action, or both. To date, several glucose-lowering drugs have been used clinically. These drugs exert their anti-diabetic effect by stimulating insulin secretion, increasing peripheral absorption of glucose, delaying the absorption of carbohydrates from the intestine and reducing hepatic gluconeogenesis. The concern over effectiveness and side effects of currently availabl

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Semwal, Alok, and Dr Niraj Gupta. "Optimization of Herbal Drug Formulations for Syzygium Cumini (Linn) Extracts: Enhancing Antidiabetic and Antioxidant Properties." Journal of Advanced Zoology 44, S7 (2023): 87–90. http://dx.doi.org/10.17762/jaz.v44is7.2728.

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The prevalence of diabetes and its associated complications continues to rise globally, creating a pressing need for effective and safe therapeutic approaches. Herbal remedies have gained significant attention as potential adjuncts or alternatives to conventional diabetes management. Syzygium cumini (Linn), commonly known as Jamun or Indian blackberry, possesses established antidiabetic and antioxidant properties. This research paper aims to optimize herbal drug formulations using Syzygium cumini extracts to enhance their antidiabetic and antioxidant effects. The study will involve extraction

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Jurendić, Tomislav, and Mario Ščetar. "Aronia melanocarpa Products and By-Products for Health and Nutrition: A Review." Antioxidants 10, no. 7 (2021): 1052. http://dx.doi.org/10.3390/antiox10071052.

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Due to factors such as cultivar, fertilization, maturation or climate conditions, as well as the date of their harvest, chokeberries (Aronia melanocarpa) differ in their content of minerals, vitamins, carbohydrates, amino acids, organic acids, fats, aroma compounds and especially polyphenols, substances exerting a beneficial impact on health. The total content of the most important ingredients, polyphenolic compounds, influence many proven chokeberry activities like antioxidative, anti-inflammatory, hypotensive, antiviral, anticancer, antiplatelet, antidiabetic and antiatherosclerotic, respect

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Amin, Elham, Mohamed Sadek Abdel-Bakky, Hamdoon A. Mohammed, and Marwa H. A. Hassan. "Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides." Life 12, no. 11 (2022): 1852. http://dx.doi.org/10.3390/life12111852.

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Natural products continue to provide inspiring chemical moieties that represent a key stone in the drug discovery process. As per our previous research, the halophyte Agathophora alopecuroides was noted as a potential antidiabetic plant. However, the chemical profiling and highlighting the metabolite(s) responsible for the observed antidiabetic activity still need to be investigated. Accordingly, the present study presents the chemical profiling of this species using the LC-HRMS/MS technique followed by a study of the ligand–protein interaction using the molecular docking method. LC-HRMS/MS re

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Mubarak, Ayad S., and Tang Yiquen. "Hypoglycemic property of cocoa products: potential underlying mechanisms." International Current Pharmaceutical Journal 4, no. 2 (2015): 362–66. http://dx.doi.org/10.3329/icpj.v4i2.21485.

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Cocoa powder and chocolate is most abundant flavonoids-plant product. Type 2 diabetes mellitus (T2DM) is health and epidemically serious metabolic disorder. The treatment and moreover preventing of T2DM is therapeutic target worldwide. This review focuses on antidiabetic mechanisms of cocoa products. Particularly, intensifying insulin sensitivity, which is a superior pathway for chronic glucose level control, and increasing insulin release for acute glucose level control. Accordingly, the hypoglycemic effect results in elevate synthesis and bioavailability of nitric oxide (NO). Subsequently, i

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K., Ahmed S., Chakrapani Cheekavolu, Naveen Alasyam, and Sunil M. "Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 179. http://dx.doi.org/10.18203/2319-2003.ijbcp20175696.

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Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxa

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Hoang, Kim Chi, Thi Hong Ha Tran, Huu Cuong Le, and Thi Nhu Hang Tran. "Antidiabetic components from a mangrove actinobacterial culture in Vietnam." Vietnam Journal of Marine Science and Technology 25, no. 2 (2025): 151–56. https://doi.org/10.15625/1859-3097/22730.

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In our quest for mangrove microbial candidates with antidiabetic potential in Vietnam, actinobacterial strains were isolated and screened for inhibitory activity against carbohydrates digesting enzymes α-amylase and α-glucosidase. As a result, Streptomyces sp. strain S-X10.2 emerged as a microbe of interest since its ethyl acetate extract exhibited inhibition rates of 62.66 ± 2.50 and 58.95 ± 1.27% against α-glucosidase and α-amylase, respectively, at test concentration of 500 µg/mL. Using column chromatography integrated with bioassays, XA1 was separated from the ethyl acetate extract and app

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Aryal, Babita, Purushottam Niraula, Karan Khadayat, et al. "Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants." Evidence-Based Complementary and Alternative Medicine 2021 (May 6, 2021): 1–15. http://dx.doi.org/10.1155/2021/5510099.

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Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural products were popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics and possess widespread biotechnological applications. The use of plant products as cosmetics and therapeutics is deep-rooted in Nepalese society. Although there are few ethnobotanical studies conducted, extensive research of these valuable medicinal plants has not been a priority due to the limitation of technology and infrastructure. Here, we selected 4 traditionally used medicinal plants to exa

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Adegbolagun, O. M., O. D. Ibukun, and O. Ale. "Comparative Physicochemical and Antioxidant Activities of Eight Commercially Available Antidiabetic Polyherbal Products." Nigerian Journal of Pharmaceutical Research 17, no. 2 (2022): 189–200. http://dx.doi.org/10.4314/njpr.v17i2.5.

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Background: High cost and side effects of current drugs has led to increased use of herbal preparations for Diabetes Mellitus, which is a chronic multifactorial disease associated with several complications and more than 422 million people affected worldwide. Objectives: To comparatively evaluate physicochemical and antioxidant properties of eight commercially available antidiabetic polyherbal products. Material and methods: Samples were subjected to physicochemical analysis; organoleptic tests, uniformity of weight, thin layer chromatography (TLC), phytochemical screening, heavy metals, extra

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Hussain, Hidayat. "Editorial for Special Issue “Natural Products as Potential Source of Antidiabetic Compounds”." Current Issues in Molecular Biology 45, no. 4 (2023): 2699–702. http://dx.doi.org/10.3390/cimb45040176.

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Jinarathne, Oshan Janadara, Kaumadie Sathika Jayasiri, Kenneth Ryan Hulugalla, Amila Nirmal Wanasinghe, and Sashipraba Vithanarachchi. "Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes." Journal of Modern Chemistry & Chemical Technology Volume 12, Issue 2 (2021): 1–14. https://doi.org/10.5281/zenodo.5725568.

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Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for the treatment of Type 2 diabetes as well as their mechanisms of action, which include the inhibition of carbohydrate metabolizing enzym

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Li, Xin, Jingling Liu, Qinxiang Chang, Ziyun Zhou, Ruilian Han, and Zongsuo Liang. "Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys." Molecules 26, no. 9 (2021): 2417. http://dx.doi.org/10.3390/molecules26092417.

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Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins for the prevention and treatment of type 2 diabetes with higher content and better activity and get their structure elucidated. First, the total proanthocyanidins contents (TOPCs), antioxidant activity, antidiabetic activity of seven common Polygonaceae plants were analyzed and compared. Then proanthocyanidins from the rhizome of Fagopyrum dibotrys were purified, and the detailed structure was comprehensively analyzed by ultraviolet visible s

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Mbegeze, Mussa B., Joan J. E. Munissi, Flora Stephano, Ramadhani S. O. Nondo, and Stephen S. Nyandoro. "Antidiabetic Potential of Vitex mombassae Fruits Extract in Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model." Tanzania Journal of Science 49, no. 4 (2023): 776–87. http://dx.doi.org/10.4314/tjs.v49i4.1.

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Besides changes in life styles and improper dietary patterns, the rapidly increasing burden of diabetes mellitus type 2 is correlated with antidiabetic agents currently in clinical use, which are costly, less effective, and present undesirable side effects. Natural products from plants are promising alternative sources for developing more effective and cost friendly antidiabetic agents. This study therefore investigated the antidiabetic potential of Vitex mombassae fruits extract (VMFE) in streptozotocin-nicotinamide induced diabetic Wistar rat model. Oral acute toxicity test was conducted in

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Uraiha, Suman, Jyoti Maitry, Lata Patel Choudhary, and Yogesh Pounikar. "Revisiting New Classes of Chalcones from Antidiabetic Perspectives." International Journal of Medical & Pharmaceutical Sciences 13, no. 12 (2023): 08–13. http://dx.doi.org/10.31782/ijmps.2023.131202.

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Elevated blood sugar levels and a plethora of other, more diverse diseases, including changes to protein, carbohydrate, and lipid metabolism, are the only hallmarks of diabetes mellitus. Recent research has shown that mice lacking PTP1B had better glucose tolerance, less diet-induced obesity, and insulin sensitivity in general. In the therapy of serious diabetic problems, natural chalcones have recently been discovered, which have superior selectivity and do not affect pharmacokinetics. This is in response to the present demand for improved PTP-1B inhibitors. No appropriate formulation has bee

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