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Journal articles on the topic 'Antidiabetogenic'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Matsuda, Hisashi, Toshio Morikawa, and Masayuki Yoshikawa. "Antidiabetogenic constituents from several natural medicines." Pure and Applied Chemistry 74, no. 7 (2002): 1301–8. http://dx.doi.org/10.1351/pac200274071301.

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In the course of our studies on antidiabetogenic and antidiabetic principles of natural medicines and medicinal foodstuffs, we have isolated salacinol and kotalanol with unique thiosugar sulfonium sulfate inner salt structures from the antidiabetic Ayurvedic traditional medicines, Salacia reticulata and S. oblonga. Salacinol and kotalanol showed potent inhibitory activities against intestinal α-glucosidase, and also inhibitory effects of salacinol on the increase in serum glucose levels in maltose- and sucrose-loaded rats were found to be more potent than those of acarbose. In addition, variou

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2

Bouhrim, Mohamed, Nour Elhouda Daoudi, Hayat Ouassou, et al. "Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil." Scientific World Journal 2020 (September 28, 2020): 1–8. http://dx.doi.org/10.1155/2020/5717052.

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Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evalu

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3

Nicoletti, F., P. Zaccone, R. D. Marco, et al. "Paradoxical Antidiabetogenic Effect of -Interferon in DP-BB Rats." Diabetes 47, no. 1 (1998): 32–38. http://dx.doi.org/10.2337/diab.47.1.32.

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4

Ahren, B. "Antidiabetogenic Action of Cholecystokinin-8 in Type 2 Diabetes." Journal of Clinical Endocrinology & Metabolism 85, no. 3 (2000): 1043–48. http://dx.doi.org/10.1210/jc.85.3.1043.

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5

Ahrén, Bo, Jens Juul Holst, and Suad Efendic. "Antidiabetogenic Action of Cholecystokinin-8 in Type 2 Diabetes*." Journal of Clinical Endocrinology & Metabolism 85, no. 3 (2000): 1043–48. http://dx.doi.org/10.1210/jcem.85.3.6431.

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6

Matsuda, Hisashi, Yasunobu Asao, Seikou Nakamura, et al. "Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon." CHEMICAL & PHARMACEUTICAL BULLETIN 57, no. 5 (2009): 487–94. http://dx.doi.org/10.1248/cpb.57.487.

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7

Yoshikawa, Masayuki, and Hisashi Matsuda. "Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs." BioFactors 13, no. 1-4 (2000): 231–37. http://dx.doi.org/10.1002/biof.5520130136.

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8

Jagetia, Ganesh Chandra. "Antidiabetogenic action of jamun syzygium cumini skeels: a review." International Journal of Complementary & Alternative Medicine 16, no. 2 (2023): 88–96. http://dx.doi.org/10.15406/ijcam.2023.16.00636.

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This review delineates the utility of Jamun, Syzygium cumini in the treatment of diabetes and hyperlipidemia. The has been written by making thorough internet search on google scholar, PubMed, SciFinder, Science direct and many other websites. Diabetes is a common disorder inflicting children and adults equally. Diabetes mellitus is mainly of two types insulin dependent (IDDM-Type I) and non-insulin-dependent diabetes mellitus (NIDDM, Type II). The Type I diabetes is more common in children, whereas the Type II diabetes highly prevalent inflicting adults more. Jamun or Syzygium cumini belongs

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9

Dutta Das, Soma, Dr Pijush Kanti Das, Manisha Ghosh, Nilanjana Banerjee, and Sandip Kumar Sinha. "Antihyperglycemic effects of hydro-ethanolic extract of Coldenia procumbens in Streptozotocin induced diabetic male albino rat." South Asian Journal of Experimental Biology 15, no. 1 (2025): 1–8. https://doi.org/10.38150/sajeb.15(1).p1-8.

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In recent times, several synthetic drugs are available in the market to treat diabetes mellitus but none can completely cure without any side effects. Indian conventional medicine system recommended herbal therapy for the treatment of different human ailments including diabetes mellitus. In present study, hydro-ethanolic extract of whole plant of Coldenia procumbens L. was found to have potent antidiabetogenic activity that reduces fasting blood glucose level in Streptozotocin induced diabetic male Albino rat. Plant extract was administered orally by gavage at the dose of 20 mg/0.5 ml distille

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10

Akrom, Akrom, Rizma Nurfadjrin, Endang Darmawan, and Titiek Hidayati. "Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression." International Journal of Public Health Science (IJPHS) 7, no. 3 (2018): 207. http://dx.doi.org/10.11591/ijphs.v7i3.13694.

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<span lang="EN-US">Black cumin seed oil (BCSO) contains many thymoquinone and unsaturated fatty acids that act as antioxidants. Thymoquinone was thought to inhibit pancreatic damage and prevent hyperglycemia by involving p53. The study aim</span><span lang="IN">ed</span><span lang="EN-US"> to determine the BCSO effect on Malondialdehyde</span><span lang="IN"> (MDA)</span><span lang="EN-US"> levels and p53 expression of pancreatic tissues in alloxan-induced Sprague Dawley (SD) rats. This study used Pre and Post Test with Control Group Design

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11

Ahrén, Bo. "Antidiabetogenic action of truncated glucagon-like peptide-1 in mice." Endocrine 3, no. 5 (1995): 367–69. http://dx.doi.org/10.1007/bf03021420.

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12

Nicoletti, F., P. Zaccone, R. Di Marco, et al. "Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats." Diabetes 47, no. 1 (1998): 32–38. http://dx.doi.org/10.2337/diabetes.47.1.32.

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13

Akrom, Nurfadjrin Rizma, Darmawan Endang, and Hidayati Titiek. "Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression." International Journal of Public Health Science (IJPHS) 7, no. 3 (2018): 207~215. https://doi.org/10.11591/ijphs.v7i3.13694.

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Black cumin seed oil (BCSO) contains many thymoquinone and unsaturated fatty acids that act as antioxidants. Thymoquinone was thought to inhibit pancreatic damage and prevent hyperglycemia by involving p53. The study aimed to determine the BCSO effect on Malondialdehyde (MDA) levels and p53 expression of pancreatic tissues in alloxan-induced Sprague Dawley (SD) rats. This study used Pre and Post Test with Control Group Design with 49 male Sprague Dawley rats aged 30 days weighing 150 - 300 gram. Rats were divided into 7 groups: Group I, the normal control group receiving standard feeding and d

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14

Pabón, Martha L., and Juan E. Carulla. "Compuestos lipídicos benéficos para la salud humana asociados a la nutrición animal." Revista Colombiana de Ciencias Pecuarias 21, no. 1 (2009): 10. http://dx.doi.org/10.17533/udea.rccp.324263.

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Summary Animal derived foods used for human consumption have received unfavorable perception because of their high contents of saturated fat. Conjugated linoleic acid (CLA, cis9-trans11) is a compound reported to have anticarcinogenic, antidiabetogenic, antiadipogenic, and antiatherogenic properties as well as having positive effects for the immune system and bone mineralization. Its concentration in meat and milk is higher in grazing animals than in those in other feeding systems. Natural CLA-enriched milk offer a new perspective for Colombian milk in the international markets.

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15

Zheng, Xin Xiao, Alan W. Steele, Wayne W. Hancock, et al. "IL-2 Receptor-Targeted Cytolytic IL-2/Fc Fusion Protein Treatment Blocks Diabetogenic Autoimmunity in Nonobese Diabetic Mice." Journal of Immunology 163, no. 7 (1999): 4041–48. http://dx.doi.org/10.4049/jimmunol.163.7.4041.

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Abstract High affinity IL-2R5 is present on recently activated but not on resting or memory T cells. Selective targeting of T cells bearing high affinity IL-2R is an attractive therapy for many T cell-dependent cytopathic disease processes. A variety of rodent mAbs directed against the α-chain of the IL-2R, as well as IL-2 fusion toxins, have been used in animals and humans to achieve selective immunosuppression. Here we report on the development of a novel IL-2R targeting agent, a cytolytic chimeric IL-2/Fc fusion protein. This immunoligand binds specifically and with high affinity to IL-2R a

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16

Lim, Kyu Hee, Ji-Hui Han, Jae Yeon Lee, et al. "Assessment of antidiabetogenic potential of fermented soybean extracts in streptozotocin-induced diabetic rat." Food and Chemical Toxicology 50, no. 11 (2012): 3941–48. http://dx.doi.org/10.1016/j.fct.2012.08.036.

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17

Kumar, Pradeep, Alok Sharma, Paresh Varshney, and Chandana Venkateswara Rao. "Antidiabetogenic and antioxidant effects of Caralluma attenuata extract on streptozotocin induced diabetes in rats." Journal of Pharmacy Research 7, no. 3 (2013): 257–62. http://dx.doi.org/10.1016/j.jopr.2013.03.021.

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18

Busquets, Sílvia, Maite Figueras, Vanessa Almendro, Francisco J. López-Soriano, and Josep M. Argilés. "Interleukin-15 increases glucose uptake in skeletal muscle An antidiabetogenic effect of the cytokine." Biochimica et Biophysica Acta (BBA) - General Subjects 1760, no. 11 (2006): 1613–17. http://dx.doi.org/10.1016/j.bbagen.2006.09.001.

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19

Wasko, Mary Chester M., Candace K. McClure, Sheryl F. Kelsey, Kimberly Huber, Trevor Orchard, and Frederico G. S. Toledo. "Antidiabetogenic effects of hydroxychloroquine on insulin sensitivity and beta cell function: a randomised trial." Diabetologia 58, no. 10 (2015): 2336–43. http://dx.doi.org/10.1007/s00125-015-3689-2.

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20

Kochergina, A. M., and N. A. Kochergin. "Effects of angiotensin II receptor blockers on the course of the disease in patients with stable ischemic heart disease." Complex Issues of Cardiovascular Diseases 11, no. 1 (2022): 124–34. http://dx.doi.org/10.17802/2306-1278-2022-11-1-124-134.

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Highlights. The review synthesizes the results of clinical studies on the use of sartans. This topic is highly relevant due to the antihypertensive, metabolic and organ-protective effect of sartans, which can positively affect the course of coronary atherosclerosis.Abstract. Angiotensin II receptor blockers (sartans) are widely used to treat cardiovascular diseases. This class of drugs has antihypertensive and metabolic effects and organ-protective capabilities. Currently, sartans are of high interest due to their pleiotropic effect: improved lipid metabolism, antidiabetogenic action, nephropr

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21

Tsai, Sue, Pau Serra, Xavier Clemente-Casares, Robyn M. Slattery, and Pere Santamaria. "Dendritic Cell–Dependent In Vivo Generation of Autoregulatory T Cells by Antidiabetogenic MHC Class II." Journal of Immunology 191, no. 1 (2013): 70–82. http://dx.doi.org/10.4049/jimmunol.1300168.

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22

Sharma, Suman Bala, Shipra Gupta, Rini Ac, Usha Rani Singh, Reenu Rajpoot, and Santosh Kumar Shukla. "Antidiabetogenic action of Morus rubra L. leaf extract in streptozotocin‐induced diabetic rats." Journal of Pharmacy and Pharmacology 62, no. 2 (2010): 247–55. http://dx.doi.org/10.1211/jpp.62.02.0013.

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23

Yoshikawa, Masayuki, Fengming Xu, Toshio Morikawa, et al. "Medicinal Flowers. XII.1) New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from Borassus flabellifer." CHEMICAL & PHARMACEUTICAL BULLETIN 55, no. 2 (2007): 308–16. http://dx.doi.org/10.1248/cpb.55.308.

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24

Morikawa, Toshio, Saowanee Chaipech, Hisashi Matsuda, et al. "Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii." Bioorganic & Medicinal Chemistry 20, no. 2 (2012): 832–40. http://dx.doi.org/10.1016/j.bmc.2011.11.067.

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25

Piamphon, Nonthasak, Chalong Wachirapakorn, Metha Wanapat, and Chainarong Nawanukrow. "Effects of fatty acid sources on conjugated linoleic acid (CLA) and other fatty acids in dairy milk." Proceedings of the British Society of Animal Science 2007 (April 2007): 20. http://dx.doi.org/10.1017/s1752756200019232.

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Conjugated linoleic acid (CLA) is aniticarcinogenic, antiatherogenic and antidiabetogenic actives. Research has therefore focused on methods of increasing CLA content in milk fat. Amount of CLA in milk fat was highly related to biohydrogenation of unsaturated fatty acid of rumen microbes. (Bauman et al., 1999). Linoleic acid (C18:2) were the precursors of CLA synthesis. The CLA was also synthesized in the mammary gland of lactating ruminants, using oleic acid (C18:1) as a precursor and activity of delta 9-desaturase (Griinari and Bauman, 1999). Linoleic acid is high in soybean oil (SO) (54.4%)

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26

Christian, Ezeigwe Obiajulu, Ezeonu Francis Chukwuemeka, and Nnadi Naomi Ngozi. "Phytochemistry and antidiabetogenic property of aqueous extract of Azadirachta indica leaf in streptozotocin-induced diabetic rats." Journal of Phytopharmacology 9, no. 3 (2020): 155–63. http://dx.doi.org/10.31254/phyto.2020.9301.

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27

Bar-Tana, Jacob, Shoshana Ben-Shoshan, Jochanan Blum, et al. "Synthesis and hypolipidemic and antidiabetogenic activities of .beta.,.beta.,.beta.',.beta.'-tetrasubstituted, long-chain dioic acids." Journal of Medicinal Chemistry 32, no. 9 (1989): 2072–84. http://dx.doi.org/10.1021/jm00129a010.

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28

Bryzgalova, Galyna, Lovisa Lundholm, Neil Portwood, et al. "Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice." American Journal of Physiology-Endocrinology and Metabolism 295, no. 4 (2008): E904—E912. http://dx.doi.org/10.1152/ajpendo.90248.2008.

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The high-fat diet (HFD)-fed mouse is a model of obesity, impaired glucose tolerance, and insulin resistance. The main objective of this study was to elucidate the molecular mechanisms underlying the antidiabetogenic and weight-lowering effects of 17β-estradiol (E2) in this mouse model. C57BL/6 female mice (8 wk old) were fed on a HFD for 10 mo. E2, given daily (50 μg/kg sc) during the last month of feeding, decreased body weight and markedly improved glucose tolerance and insulin sensitivity. Plasma levels of insulin, leptin, resistin, and adiponectin were decreased. We demonstrated that E2 tr

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29

Valerio, Anna, Daniela Basso, Paola Fogar, et al. "Maldi-TOF analysis of portal sera of pancreatic cancer patients: identification of diabetogenic and antidiabetogenic peptides." Clinica Chimica Acta 343, no. 1-2 (2004): 119–27. http://dx.doi.org/10.1016/j.cccn.2003.12.021.

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30

Zheng, X. X., A. W. Steele, W. W. Hancock, et al. "A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice." Journal of Immunology 158, no. 9 (1997): 4507–13. http://dx.doi.org/10.4049/jimmunol.158.9.4507.

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Abstract We have been successful in our efforts to develop a long lived noncytolytic murine IL-10/Fc fusion protein. In the nonobese diabetic mouse (NOD) model, administration of IL-10/Fc from 5 to 25 wk of age completely prevented the occurrence of diabetes. Moreover, these mice remained disease-free long after cessation of IL-10/Fc therapy. Immunohistochemistry studies show that IL-10/Fc treatment inhibits expression of TNF-alpha, proinflammatory cytokine, as well as Th1-type cytokines, IL-2 and IFN-gamma, but promotes expression of IL-4 and IL-10, Th2-type cytokines, by islet-infiltrating l

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31

Magalhães-Santos, Juliana, Rafael Loureiro Simões, Carla Ade Caldas, et al. "Irisin modulates bone marrow derived macrophage polarization towards M2 profile in high fat fed mice." Concilium 23, no. 21 (2023): 36–50. http://dx.doi.org/10.53660/clm-2386-23s13.

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Background and Aims: The chronic inflammatory process in the adipose tissue during obesity suggests constant polarization of classically activated macrophages (M1) and low polarization of alternately activated ones (M2). Since irisin has anti-inflammatory and antidiabetogenic properties our aim is to evaluate its effects on macrophage polarization in mice subjected to high fat diet. Methods and Results: C57Bl/6 mice were fed a high fat diet for 30 weeks. Bone marrow derived macrophages (BMDM) were isolated and incubated with 50 nM of irisin. Cellular phenotype, nitrite production, arginase-1 e

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32

Ambiara, Fahima Binthe Aziz, Md Mahmudul Hasan, et al. "Antidiabetogenic impact of bitter melon (Momordica charantia) and garlic (Allium sativum) on alloxan induced diabetic rabbit model." Asian Journal of Medical and Biological Research 2, no. 3 (2016): 402–8. http://dx.doi.org/10.3329/ajmbr.v2i3.30110.

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The present study was undertaken to investigate the antidiabetic effect of the Bitter melon and Garlic on Alloxan induced diabetes in experimental rabbits. At 2 to 3 months of age, rabbits were assigned into five groups (A, B, C, D and E) and each group was remained 4 rabbits. Group A was kept for control, Group B was treated with Alloxanintramuscullarly at a dose of 75mg /kg body weight, Group C was treated with bitter melon 250gm/kg body weight orally, Group D was treated with garlic 750mg/kg body weight orally, Group E treated with combined at previous dose. After acclimatization, diabetes

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33

MAKSIMOVIC, D., M. MOSTARICA STOJKOVIC, and S. STOSIC-GRUJICIC. "Antidiabetogenic Effect of Mycophenolate Mofetil Is Associated with Down-Regulation of Adhesive Interactions and Autoreactive Cell Activation." Annals of the New York Academy of Sciences 958, no. 1 (2006): 148–51. http://dx.doi.org/10.1111/j.1749-6632.2002.tb02958.x.

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34

Yoshikawa, Masayuki, Seikou Nakamura, Kenichi Ozaki, Akira Kumahara, Toshio Morikawa, and Hisashi Matsuda. "Structures of Steroidal Alkaloid Oligoglycosides, Robeneosides A and B, and Antidiabetogenic Constituents from the Brazilian Medicinal PlantSolanumlycocarpum." Journal of Natural Products 70, no. 2 (2007): 210–14. http://dx.doi.org/10.1021/np0680580.

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35

Horvath, Emily M., Lixuan Tackett, Alicia M. McCarthy, Priya Raman, Joseph T. Brozinick, and Jeffrey S. Jeffrey S. "Antidiabetogenic Effects of Chromium Mitigate Hyperinsulinemia-Induced Cellular Insulin Resistance via Correction of Plasma Membrane Cholesterol Imbalance." Molecular Endocrinology 22, no. 4 (2008): 937–50. http://dx.doi.org/10.1210/me.2007-0410.

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Previously, we found that a loss of plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2)-regulated filamentous actin (F-actin) structure contributes to insulin-induced insulin resistance. Interestingly, we also demonstrated that chromium picolinate (CrPic), a dietary supplement thought to improve glycemic status in insulin-resistant individuals, augments insulin-regulated glucose transport in insulin-sensitive 3T3-L1 adipocytes by lowering PM cholesterol. Here, to gain mechanistic understanding of these separate observations, we tested the prediction that CrPic would protect again

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36

Choi, S. H., and H. C. Lee. "Long-term, antidiabetogenic effects of GLP-1 gene therapy using a double-stranded, adeno-associated viral vector." Gene Therapy 18, no. 2 (2010): 155–63. http://dx.doi.org/10.1038/gt.2010.119.

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37

Hailu, Yonas, Egon Bech Hansen, Eyassu Seifu, Mitiku Eshetu, Richard Ipsen, and Stefan Kappeler. "Functional and technological properties of camel milk proteins: a review." Journal of Dairy Research 83, no. 4 (2016): 422–29. http://dx.doi.org/10.1017/s0022029916000686.

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This review summarises current knowledge on camel milk proteins, with focus on significant peculiarities in protein composition and molecular properties. Camel milk is traditionally consumed as a fresh or naturally fermented product. Within the last couple of years, an increasing quantity is being processed in dairy plants, and a number of consumer products have been marketed. A better understanding of the technological and functional properties, as required for product improvement, has been gained in the past years. Absence of the whey protein β-LG and a low proportion of к-casein cause diffe

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38

Okafor Ifeanyi Fidelis, Igboeli Chukwuduziem Nnamdi, Awuzie Ifechukwu Milicent, and Akabuike Chioma. "Evaluation of antidiabetic effect of ethanol extract of Phaseolus vulgaris SEEDS ON alloxan-induced Wistar diabetic rats." International Journal of Science and Research Archive 13, no. 1 (2024): 678–83. http://dx.doi.org/10.30574/ijsra.2024.13.1.1698.

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This work was designed to evaluate the anti-diabetic efficacy of ethanol extract of Phaseolus vulgaris seeds in normal and in alloxan -induced diabetic rats. The blood glucose level of the rats was checked before the administration of alloxan using One Touch Glucometer and test strips. The rats were then fasted for 16 hours, but with free access to water after which they received an intraperitoneal injection of alloxan 200 mg/kg body weight. The rats were orally given 20 ml each of 75% glucose solution after 3 hours to prevent hypoglycemia. The animals were allowed free access to food and wate

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39

Abikenova, Fatima S., Gabit Meyramov, Saule Zhautikova, et al. "Investigation of Antidiabetogenic Effect of the Iodine-Selenium Concentrate in Animals with Chronic Alloxan Diabetes of Varying Severity." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 535–40. http://dx.doi.org/10.3889/oamjms.2021.5873.

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BACKGROUND: The diabetogenic effect of alloxan is known is determined by ability to stimulate lipid peroxydation processes in B-cells of the pancreas. AIM: to investigate of the possible antidiabetic action of long time prolonged of Iodine-Selenium concentrate action in rats with alloxan diabetes. METHODS: Reproduction of experimental alloxan diabetes was carried out in rats by a single intravenous injection of alloxan 35-43 mg / kg body weight. The “iodine-selenium” concentrate was administered per os through a tube at the rate of 1.25 ml / 100 g of the concentrate. In experimenta

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40

Garzón, Antonela G., Flávio F. Veras, Adriano Brandelli, and Silvina R. Drago. "Purification, identification and in silico studies of antioxidant, antidiabetogenic and antibacterial peptides obtained from sorghum spent grain hydrolysate." LWT 153 (January 2022): 112414. http://dx.doi.org/10.1016/j.lwt.2021.112414.

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41

Narendhirakannan, RT, S. Subramanian, and M. Kandaswamy. "BIOCHEMICAL EVALUATION OF ANTIDIABETOGENIC PROPERTIES OF SOME COMMONLY USED INDIAN PLANTS ON STREPTOZOTOCIN-INDUCED DIABETES IN EXPERIMENTAL RATS." Clinical and Experimental Pharmacology and Physiology 33, no. 12 (2006): 1150–57. http://dx.doi.org/10.1111/j.1440-1681.2006.04507.x.

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42

Tsai, Sue, Pau Serra, Xavier Clemente-Casares, et al. "Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+regulatory T cells." Proceedings of the National Academy of Sciences 110, no. 9 (2013): 3471–76. http://dx.doi.org/10.1073/pnas.1211391110.

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43

Gutniak, Mark, Cathrine Ørkov, Jens J. Holst, Bo Ahrén, and Suad Efendić. "Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus." New England Journal of Medicine 326, no. 20 (1992): 1316–22. http://dx.doi.org/10.1056/nejm199205143262003.

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44

Stošić-Grujičić, Stanislava, Danijela Maksimović, Vladimir Badovinac, et al. "Antidiabetogenic Effect of Pentoxifylline is Associated with Systemic and Target Tissue Modulation of Cytokines and Nitric Oxide Production." Journal of Autoimmunity 16, no. 1 (2001): 47–58. http://dx.doi.org/10.1006/jaut.2000.0456.

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45

Roy, Kishor Kumar, Md Rakibul Islam, Md Bazlar Rashid, et al. "Antidiabetogenic impact of Bitter Melon (Momordica charantia) and Black Cumin (Nigella sativa) on alloxan induced diabetic rabbit model." Asian-Australasian Journal of Bioscience and Biotechnology 2, no. 1 (2017): 24–28. http://dx.doi.org/10.3329/aajbb.v2i1.64042.

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The present study was undertaken to investigate the antidiabetic effect of the bitter melon and black cumin on alloxan induced diabetes in experimental rabbits. At 2 to 3 months of age, rabbits were assigned into five groups (A, B, C, D and E) and rabbits were included each group. Group A was kept as control, Group B was treated with alloxan intramuscularly at a dose of 75mg /kg body weight, Group C was treated with bitter melon at a dose of 150gm/kg body weight orally, Group D was treated with black cumin at a dose of 250mg/kg body weight orally, Group E was treated with combined at previous

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Dusane, Menakshi Bhat, and Bimba N. Joshi. "Islet protective and insulin secretion property of Murraya koenigii and Ocimum tenuflorum in streptozotocin-induced diabetic mice." Canadian Journal of Physiology and Pharmacology 90, no. 3 (2012): 371–78. http://dx.doi.org/10.1139/y11-133.

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The present study investigates the antidiabetogenic effects of Murraya koenigii (L.) Spr. and Ocimum tenuflorum L. on streptozotocin-induced diabetic Swiss mice. Treatment with extracts of M. koenigii (chloroform; MKC) and O. tenuflorum (aqueous; OTA) resulted in proper glucose utilization with an increase in liver glucose-6-phosphate dehydrogenase enzyme activity, and normal glycogenesis in hepatic and muscle tissues. Pancreatic and intestinal glucosidase inhibitory activity observed with MKC and OTA treatment indicated beneficial effects in reducing postprandial hyperglycemia with concomitan

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Spasov, Alexander A., Pavel M. Vassiliev, Karina V. Lenskaya, et al. "Hypoglycemic potential of cyclic guanidine derivatives." Pure and Applied Chemistry 89, no. 8 (2017): 1007–16. http://dx.doi.org/10.1515/pac-2016-1024.

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AbstractGuanidine derivatives are widely used antidiabetic drugs. Metformin (biguanide) is the first-line therapy for the type 2 diabetes mellitus due to its multi-target and pleiotropic effects. Compounds that comprise guanidine moiety integrated in a heterocycle, i.e. cyclic guanidines, represent an increasing area of interest. We have synthesized and studied hypoglycemic effects of a range of cyclic guanidines, namely 2-aminobenzimidazoles and structurally related imidazo[1,2-a]-, pyrimido[1,2-a]-, pyrrolo[1,2-a]-, triazolo[1,5-a]benzimidazole tricyclic derivatives. We have determined the p

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Svensson, Annika M., Claes-Göran Östenson, Suad Efendic, and Leif Jansson. "Effects of glucagon-like peptide-1-(7–36)-amide on pancreatic islet and intestinal blood perfusion in Wistar rats and diabetic GK rats." Clinical Science 112, no. 6 (2007): 345–51. http://dx.doi.org/10.1042/cs20060272.

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The aim of the present study was to evaluate the effects of GLP-1 [glucagon-like peptide-1-(7–36)-amide] on total pancreatic, islet and intestinal blood perfusion in spontaneously hyperglycaemic GK rats and normal Wistar rats using a microsphere technique. GK rats had hyperglycaemia and increased pancreatic and islet blood flow. Blood glucose concentrations were not affected when measured shortly (8 min) after GLP-1 administration in either GK or Wistar rats. GLP-1 had no effects on baseline pancreatic or islet blood flow in Wistar rats, but did prevent the blood flow increase normally seen fo

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Pereira, A. C., R. Oliveira, A. C. Castro та R. Fernandes. "Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2?" PPAR Research 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/401274.

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Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders. The peroxisome proliferator activated by gamma 2 (PPARγ2) plays an important role in the lipid metabolism. Since PPARγ2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the sensitivity to insulin, diabetes, and other metabolic parameters. The present study aims to contribute to the elucidation of the impact of the Pro12Ala polymorphism associated with T2D and

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Schmidt, Dennis, Joan Verdaguer, Nuzhat Averill, and Pere Santamaria. "A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity." Journal of Experimental Medicine 186, no. 7 (1997): 1059–75. http://dx.doi.org/10.1084/jem.186.7.1059.

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Certain major histocompatibility complex (MHC) class II haplotypes encode elements providing either susceptibility or dominant resistance to the development of spontaneous autoimmune diseases via mechanisms that remain undefined. Here we show that a pancreatic beta cell–reactive, I-Ag7–restricted, transgenic TCR that is highly diabetogenic in nonobese diabetic mice (H-2g7) undergoes thymocyte negative selection in diabetes-resistant H-2g7/b, H-2g7/k, H-2g7/q, and H-2g7/nb1 NOD mice by engaging antidiabetogenic MHC class II molecules on thymic bone marrow–derived cells, independently of endogen

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