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Dissertations / Theses on the topic 'Antidiarrhoeal activity Antidiabetic activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Deliwe, Mzonke. "Pharmacological evaluation of antidiarrhoeal and antidiabetic activities of Syzygium Cordatum Hochst. ex C. Krauss." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9985_1351170857.

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Syzygium cordatum is a medicinal plant indigenous to South Africa and Mozambique, commonly used to treat stomach aches, diabetes, respiratory problems and tuberculosis. In spite of the folklore use, adequate scientific data to credit its widespread traditional use is lacking. The objectives of this study were: to evaluate and validate scientifically the successful therapeutic claims by traditional medicine practitioners that Syzygium cordatum is effective in treating diarrhoea and diabetes<br>to determine the effects of the plant extract on gastrointestinal transit of a charcoal meal in mice<b

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2

Bekale, Raymonde Bamboukou. "Investigation of the antidiabetic activity of Cnicusbenedictus L. in rats." University of the Western Cape, 2016. http://hdl.handle.net/11394/5455.

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Magister Pharmaceuticae - MPharm<br>Diabetes Mellitus, one of the major diseases affecting human population all over the world has caused significant morbidity and mortality. The management of this condition has raised the demand of safe and cost effective remedial measures due to several side effects associated with the present use of modern medicines. Thus, it is crucial to explore other options for diabetes management such as the use of medical plants. Cnicus benedictus L. is one of the known plant species used by traditional medicine practitioners in South Africa for the treatment of

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3

Mnonopi, Nandipha. "Leonotis leonurus: the anticoagulant and antidiabetic activity of Leonotis leonurus." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1194.

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Commercial marrubiin, aqueous and organic extracts of Leonotis leonurus were tested in vitro for their anticoagulant and antiplatelet activities. The aqueous extract inhibited platelet aggregation by 69.5 percent (100 μg/mL), while the organic extract (100 μg/mL) and marrubiin (5 μg/mL) showed 92.5 percent and 91.6 percent inhibition, respectively, by inhibiting the binding of fibrinogen to glycoprotein IIb/IIIa receptor in a concentration dependent manner. The extracts significantly prolonged activated partial thromboplastin time compared to untreated plasma controls. Fibrin and D-Dimer forma

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4

Ezeigbo, Ihechiluru I. "Potential antidiabetic activity of Hymenocardia acida : effects on skeletal muscle insulin resistance." Thesis, Royal Veterinary College (University of London), 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731286.

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5

Sewnarain, Prenitha. "Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action." Thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33235.

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The increasing reliance on drugs from natural sources has led to the development of several drugs from traditional plants which are present in abundance in Southern Africa. With the rapid increase of incidence of type 2 diabetes in South Africa with potentially devastating effects on healthcare, the need for alternative therapeutics is a priority. In this study, Schkuhria pinnata (Lam.) Kuntze was investigated for its antidiabetic potential. Initial screening of two different solvent extracts of S. pinnata identified an aqueous extract that lowered blood glucose concentrations in a hyperglycae

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6

Mnonopi, Nandipha Olivia. "In vitro testing to investigate the anticoagulant/antithrombotic and antidiabetic biological activity of Leonotis Leonurus." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/693.

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The rising costs of prescription drugs in the maintenance of personal health and wellbeing have increased the interest in medicinal plants. The World Health Organization estimates that 65 percent-80 percent of the world’s population use traditional medicine as their primary form of health care. In this project the focus has been on the use of Leonotis leonurus extracts as a traditional medicine. The major chemical constituent of this plant is marrubiin, which is a diterpenoid labdane lactone formed from a precursor called premarrubiin. Aqueous and acetone extract (AL and OL extract, respective

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7

Green, Brian Desmond. "Amino-terminally modified analogues of glucagon-like peptide-1 (7-36) amide : activity and antidiabetic potential." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398986.

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8

Farias, Pablo Antonio Maia de. "Antidiabetic and antibacterial activity study of a non cyanogenic cyanglycoside extracted from Bauhinia pentandra by an approach in silico." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17934.

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The flora presents a number of species with major pharmaceutical potential, however, only a small part of this arsenal is known. The identification of chemical substances of natural origin is a reality, however, the pharmacological potential of this still falls short of what could be done. The use of computational methods can optimize the search for active ingredients more effectively, optimizing time and money, and provide a reduction in the use of laboratory animals. From an isolated chemical of "Bauhinia pentandra" and called (2Z)-[(6S,7S,8R)-8-(β-d- glicopyranosyloxi)-6,7-dihydroxycyc

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9

Nicholas, Rudi Berto. "In silico and in vitro screening of marrubiin and marrubiin derivatives for antidiabetic activity on PTP1ß, C2C12 myocytes, chang liver hepatocytes and 3T3-L1 adipocytes." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1020638.

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Diabetes mellitus (DM) is a life changing disease which affects a large portion of the population and the economy through high medical costs and loss of productivity. Marrubiin (MAR), a diterpenoid isolated from Leonotis leonurus, a plant indigenous to Southern Africa, is used by traditional healers to alleviate DM symptoms. This study aims to screen the inhibitory potential of MAR and MAR derivatives on PTP1β and glucose uptake properties of Chang liver, C2C12 and 3T3-L1 cells. Marrubiin and 19 of its derivatives were tested to determine the inhibition constants for PTP1β. A Ki of 21 μM and 0

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10

Matou, Melissa. "Composition et propriétés biologiques d’extraits de Phyllanthus amarus Schumacher et thonning (1827) utilisés en médecine traditionnelle aux Antilles." Thesis, Antilles, 2019. http://www.theses.fr/2019ANTI0421.

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P. amarus, connu sous le nom de « Grenn anba fèy », est l’une des plantes les plus utilisées dans le traitement du diabète par les plantes médicinales en Guadeloupe. Elle a été introduite en 2015 dans la pharmacopée française cependant les professionnels déplorent un manque de données scientifiques sur la composition chimique de cette plante.Ce travail évalue donc pour la première fois la composition chimique et les propriétés biologiques des extraits aqueux de P. amarus en se basant sur les habitudes de consommation de la population (infusion et décoction aqueuse) qui utilise aussi bien les p

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11

Milena, Rašeta. "Детекција биоактивних супстанци одабраних врста гљива рода Ganoderma (Basidiomycota) и њихова биолошка активност". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=101530&source=NDLTD&language=en.

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 У оквиру ове докторске дисертације испитан је хемијски састав и биолошке активности ЕtOH, H<sub>2</sub>Oи CHCl<sub>3 </sub> екстраката четири врсте гљива рода<em> Ganoderma</em>  (Basidiomycota): <em> G. applanatum,  G. lucidum,G. pfeifferi,  G. resinaceum</em>  са територије Војводине.Хемијски састав анализираних врста је одређенприменом: ААЅ методе (састав макро-  имикроелемената у сувим остацима гљива) и LC-MS/MS технике (квантитативни састав фенолних једињења и флавоноида) при чему је детектовано 12 једињења. Спектрофотометријским методама је одређе

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12

Milena, Vujanović. "Hemijski sastav, biološke i funkcionalne karakteristike novih proizvoda od zove." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=115048&source=NDLTD&language=en.

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Glavni cilj ove doktorske disertacije je određivanje hemijskog sastava, biolo&scaron;kih i funkcionalnih karakteristika novih proizvoda od zove. Dobijanje proizvoda na bazi zove zasniva se na primeni tradicionalnih i savremenih tehnolo&scaron;kih procesa proizvodnje. Iskori&scaron;ćenje prirodnog potencijala zove započeto je primenom tradicionalne i savremene (liofilizacija) tehnike su&scaron;enja. U cilju dobijanja visoko-vrednih ekstrakata ploda i cveta zove primenjene su tradicionalna (maceracija) i savremene (ultrazvučna i mikrotalasna) ekstrakcione tehnike sa dva ekstragensa (50% etanol i

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13

Huang, Ming-Hua, and 黃銘華. "Investigating Antidiabetic and Antioxidative Activity of Constituents from Rheum officinale." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/85007770690075115374.

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碩士<br>國立屏東教育大學<br>化學生物系<br>99<br>In the study, dried rhizome of Rheum officinale has been extracted with methanol for six times. The crude extract was further partitioned with hexane、ethyl acetate、butanol and water. From the EtOAc layer, we obtained seven compounds, including four anthraquinones: Chrysophanol、Emodin、Physcion、Aloe-emodin; two Benzenoids: Raspberry acid、trans-Resveratrol; and an unknown A. It needs more experiments such as HMBC spectroscopy analysis to confirm the unknown A''s structure.

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14

Huang, Yen-chun, and 黃彥鈞. "Investigating Antidiabetic and Antioxidative Activity of Constituents from Artemisia apiacea." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/22109982792716012444.

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碩士<br>國立屏東教育大學<br>化學生物系<br>100<br>Artemisia apiacea is a common traditional Chinese medicine. Based on the research, the extracts of Artemisia apiacea showed good antidiabetic and antioxidative activity. Therefore, we chosed dried of Artemisia apiacea to extracted with methanol of five times. The methanol extract(AALM) was partitioned between chloroform and water. The chloroform layer(AAL-C) and precipitating layer(AAL-P) were showed the higher α-glucosidase and DPPH(2, 2-Diphenyl-1-picrylhydrazyl) inhibition effect. We used Silica gel, Diaion, Centrifugal TLC, TLC and HPLC to isolate and puri

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15

Tu, Yi-Syuan, and 凃宜瑄. "Investigating Antidiabetic and Antioxidative Activity of Lignins from Schisandra chinensis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/37095798991664648105.

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碩士<br>國立屏東大學<br>應用化學系碩士班<br>103<br>The dried fruits of Schisandra chinensis is a common traditional Chinese medicine. Based on the research, the extracts of Schisandra chinensis showed good antidiabetic activity. Thirty-five compounds were obtained and comfirmed by 1H-NMR, UV, and IR： macelignan (76)、schisandrin A (78)、gomisin K3 (80)、gomisin J (81)、schisandrin B (83)、gomisin N (84)、gomisin M2 (85)、gomisin L2 (86)、(-)-gomisin L1 (87)、(S)-angeloylgomisin M1 (90)、(R)-angeloylgomisin M1 (90)、schisandrin C (91)、schisandrin (93)、angeloylgomisin H (94)、tigloylgomisin H (95)、gomisin A (100)、schisandr

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16

Chen, Meng-Chun, and 陳孟君. "Evaluation of fish skin gelatin hydrolysates inhibit dipeptidyl peptidase IV activity and their antidiabetic effect." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/33268620466846546364.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>101<br>A novel approach for treatment of type 2 diabetes is the use of gut hormone glucagon-like peptide-1 (GLP-1), which possesses multi-functions such as the stimulation of insulin secretin and the blood glucose homeostasis. GLP-1 is a polypeptide that is rapidly inactivated by dipeptidyl peptidase IV (DPP-IV). DPP-IV is a postproline-cleaving enzyme with the specificity for removing X-proline or X-alanine dipeptides from the N-terminus of polypeptides. Therefore, the peptides with Pro or Ala as the penultimate amino acid residue of N-terminus would be efficient DP

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17

Nkobole, Nolitha Khanya. "Antidiabetic activity of pentacyclic triterpenes and flavonoids isolated from stem bark of Terminalia sericea Burch.Ex DC." Diss., 2009. http://hdl.handle.net/2263/28896.

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Diabetes mellitus (DM) represents a series of metabolic conditions associated with hyperglycemia and caused by defects in insulin secretion, and/ insulin action. Exposure to chronic hyperglycemia may result in microvascular complications in the retina, kidney or peripheral nerves. According to the World Health Organization (WHO) global burden of disease, more than 176 million people are diabetic with about two thirds of these living in developing countries. With a long course and serious complications that often result in high incidences of mobility and mortality rate, the treatment of diabete

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18

Proença, Carina Isabel Coelho. "Assessment of the antidiabetic activity of flavonoids: targeting key enzymes involved in type 2 diabetes pathophysiology." Tese, 2021. https://hdl.handle.net/10216/133703.

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19

Proença, Carina Isabel Coelho. "Assessment of the antidiabetic activity of flavonoids: targeting key enzymes involved in type 2 diabetes pathophysiology." Doctoral thesis, 2021. https://hdl.handle.net/10216/133703.

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20

Mohamed, Mahmoud Eid Hoda. "Antidiabetic activity of Vaccinium vitis-idaea, a medicinal plant from the traditional pharmacopeia of the James Bay Cree." Thèse, 2010. http://hdl.handle.net/1866/8327.

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L’incidence du diabète chez les premières nations du Canada est plus de trois fois celle du reste du pays, dû, en partie, aux traitements culturellement inappropriés. Notre projet vise à traiter le diabète chez ces populations à partir de leur pharmacopée de médicine traditionnelle afin d’améliorer l’acceptation des traitements. En utilisant une approche ethnobotanique, notre équipe a identifié 17 plantes médicinales utilisées pour traiter des symptômes du diabète par les Cris d'Eeyou Istchee (Baie James, Québec). Parmi eux, l'extrait éthanolique de baies de Vaccinium vitis-idaea a montré un e

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21

Paddy, Veronica. "Determination of the in vitro antidiabetic potential of a polyherbal commercial tea." Diss., 2014. http://hdl.handle.net/2263/43216.

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Type 2 diabetes mellitus (T2DM) is an increasing global health concern, currently affecting an estimated 382 million individuals. There is no cure for T2DM and the search for new and improved treatments is ongoing. Presently, various pharmacological regimens are available to treat T2DM, but with varied success. Thousands of traditional herbs are also used to treat T2DM, but mainly without scientific validation. The aim of this study was to assess the polyphenolic content, antioxidant capacity, as well as in vitro toxicity and hypoglycaemic activity of a commercial ‘antidiabetic’ tea mixture (D

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22

Tomé, Sara Mirassol. "Synthesis of flavonoid-type compounds and sugar-substituted phenolics of pharmacological importance." Doctoral thesis, 2021. http://hdl.handle.net/10773/31390.

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Flavonoids are a large class of secondary metabolites widespread in the Plant Kingdom. These natural organic compounds possess a prominent interest as therapeutic agents. Among the vast range of biological properties of both natural and synthetic derivatives are their antioxidant and anti-inflammatory activities. Among the naturally occurring oxygen containing heterocyclic compounds, flavones (2-arylchromones) assume pronounced importance due to both their spread and diverse abundance as well as their well-known wide range of pharmacological properties. Halogenated derivatives of

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23

Harbilas, Despina. "Antiobesity and antidiabetic activity of P. balsamifera, its active Salicortin, and L. laricina, medicinal plants from the traditional pharmacopoeia of the James Bay Cree." Thèse, 2012. http://hdl.handle.net/1866/8905.

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La prévalence de l’obésité, du diabète de type 2, et du syndrome métabolique, sont à la hausse chez les Cris d’Eeyou Istchee (CEI-Nord du Québec). Ces problèmes sont aggravés par leur diète non traditionnelle, leur sédentarité, ainsi que par une résistance culturelle aux produits pharmaceutiques. Afin de développer des traitements antidiabétiques culturellement adaptés, notre équipe a effectué une enquête ethnobotanique qui a identifié 17 plantes provenant de la pharmacopée traditionnelle des CEI. À partir des études de criblage effectuées in vitro, deux plantes parmi les 17 ont attiré notre a

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24

Martins, Ana Sofia Lourenço. "Relatórios de Estágio e Monografia intitulada "Fitoterapia no tratamento complementar da Diabetes Mellitus"." Master's thesis, 2019. http://hdl.handle.net/10316/88386.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Este documento está divido em três partes, dois relatórios de estágio e a monografia.Cada relatório de estágio consiste numa análise SWOT, em que são abordados os pontos fortes e fracos, bem como as oportunidades e as ameaças sentidas durante a realização dos mesmos.O título da monografia é “Fitoterapia no tratamento complementar da Diabetes Mellitus”.Nas últimas décadas, a prevalência da Diabetes Mellitus (DM) aumentou significativamente, cerca de 425 milhões de pessoas vivem com esta d

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25

Bento, Catarina Pereira. "Peach from Cova da Beira as Health Promotors." Master's thesis, 2016. http://hdl.handle.net/10400.6/6295.

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The peach’s chemical constitution comprises various antioxidant compounds such as phenolic compounds (flavonoids and non-flavonoids) carotenoids and vitamin C. Their properties have been object of investigation in many areas, proving to have preventive and protective effects against many chronic and age-related diseases such as diabetes, obesity, hypertension, inflammation, cardiovascular, neurodegenerative and oncologic diseases. In this work we evaluate the phenolic profile and biological potential of six peach cultivars (Summer Rich, Fidelia, Royal Glory, Royal Magister, Royal Lu and Sweet

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